essentiality_rank ml_id entry gene_names protein_names sequence_length esm2_essentiality_probability esm2_call hansen_essentiality_score hansen_essentiality_call confidence agreement review_flag mtb_ortholog ortholog_identity mtb_call mtb_essential proteomelm_context_percentile target_priority_score priority_tier rationale model_version computed_at 1 ML0901 Q7AQD0 ML0901 Methylenetetrahydrofolate reductase 304 0.38444 non-essential 0.56198 essential low disagree review_anchor_disagreement Rv2172c 81.3 ES 1 0.50031 62.571 Moderate candidate ESM-2 calibrated P(essential)=0.384; HANSEN integrated essentiality score=0.562; Mtb RBH anchor Rv2172c=essential (disagree); ProteomeLM contextual percentile=0.500; target-priority score=62.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 2 ML1961 Q9X7A2 rpmJ ML1961 MLCB1222.31c Large ribosomal subunit protein bL36 (50S ribosomal protein L36) 37 0.42684 non-essential 0.54189 essential medium NA medium_confidence NP_217978.1 89.2 0.99123 80.9 High-priority ESM-2 calibrated P(essential)=0.427; HANSEN integrated essentiality score=0.542; ProteomeLM contextual percentile=0.991; target-priority score=80.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 3 ML2413 Q7APU9 ML2413 Possible phosphoglycerate mutase 202 0.28398 non-essential 0.53281 essential low disagree review_anchor_disagreement Rv0525 82.1 ES 1 0.77019 70.804 Strong candidate ESM-2 calibrated P(essential)=0.284; HANSEN integrated essentiality score=0.533; Mtb RBH anchor Rv0525=essential (disagree); ProteomeLM contextual percentile=0.770; target-priority score=70.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 4 ML0325 Q9CCW3 ML0325 Uncharacterized protein 87 0.42684 non-essential 0.53237 essential medium NA medium_confidence 0.96055 72.277 Strong candidate ESM-2 calibrated P(essential)=0.427; HANSEN integrated essentiality score=0.532; ProteomeLM contextual percentile=0.961; target-priority score=72.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 5 ML0810 Q9CCH4 ML0810 Membrane protein 407 0.28398 non-essential 0.52752 essential low disagree review_anchor_disagreement Rv3212 79.9 GD 1 0.73012 68.238 Strong candidate ESM-2 calibrated P(essential)=0.284; HANSEN integrated essentiality score=0.528; Mtb RBH anchor Rv3212=essential (disagree); ProteomeLM contextual percentile=0.730; target-priority score=68.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 6 ML0593 Q49689 ML0593 B1496_C2_189 MLCL536.28c Iron-sulfur cluster assembly SufBD family protein ML0593 [Cleaved into: Mle pps1 intein] 869 0.28398 non-essential 0.52431 essential low disagree review_anchor_disagreement Rv1461 52.1 ES 1 0.70632 66.572 Strong candidate ESM-2 calibrated P(essential)=0.284; HANSEN integrated essentiality score=0.524; Mtb RBH anchor Rv1461=essential (disagree); ProteomeLM contextual percentile=0.706; target-priority score=66.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:45Z 7 ML2204 Q9CBC3 ML2204 DUF3073 domain-containing protein 62 0.23311 non-essential 0.52333 essential low disagree review_anchor_disagreement Rv0810c 77.8 ES 1 0.97495 71.94 Strong candidate ESM-2 calibrated P(essential)=0.233; HANSEN integrated essentiality score=0.523; Mtb RBH anchor Rv0810c=essential (disagree); ProteomeLM contextual percentile=0.975; target-priority score=71.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 8 ML1395 Q9CC21 rpmI ML1395 Large ribosomal subunit protein bL35 (50S ribosomal protein L35) 64 0.42684 non-essential 0.52183 essential medium NA medium_confidence NP_216158.1 90.6 0.89042 75.041 Strong candidate ESM-2 calibrated P(essential)=0.427; HANSEN integrated essentiality score=0.522; ProteomeLM contextual percentile=0.890; target-priority score=75.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 9 ML0603 Q7AQH2 ML0603 DNA-directed DNA polymerase (EC 2.7.7.7) 371 0.27619 non-essential 0.51816 essential low disagree review_anchor_disagreement Rv2413c 83.5 ES 1 0.6531 74.27 Strong candidate ESM-2 calibrated P(essential)=0.276; HANSEN integrated essentiality score=0.518; Mtb RBH anchor Rv2413c=essential (disagree); ProteomeLM contextual percentile=0.653; target-priority score=74.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 10 ML1347 Q9CC33 ML1347 UPF0434 protein ML1347 77 0.23623 non-essential 0.51516 essential low disagree review_anchor_disagreement Rv1684 70.1 GD 1 0.87664 71.508 Strong candidate ESM-2 calibrated P(essential)=0.236; HANSEN integrated essentiality score=0.515; Mtb RBH anchor Rv1684=essential (disagree); ProteomeLM contextual percentile=0.877; target-priority score=71.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 11 ML2629 Q7APS8 ML2629 Coenzyme Q-binding protein COQ10 START domain-containing protein 156 0.24246 non-essential 0.51496 essential low disagree review_anchor_disagreement Rv0164 76.8 ES 1 0.83156 72.642 Strong candidate ESM-2 calibrated P(essential)=0.242; HANSEN integrated essentiality score=0.515; Mtb RBH anchor Rv0164=essential (disagree); ProteomeLM contextual percentile=0.832; target-priority score=72.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 12 ML0173 Q9CD69 rpmF ML0173 Large ribosomal subunit protein bL32 (50S ribosomal protein L32) 57 0.38086 non-essential 0.50242 essential medium NA medium_confidence YP_177635.1 84.2 0.97871 77.924 Strong candidate ESM-2 calibrated P(essential)=0.381; HANSEN integrated essentiality score=0.502; ProteomeLM contextual percentile=0.979; target-priority score=77.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 13 ML2195 Q7APX9 ML2195 Probable exported protein 283 0.23815 non-essential 0.50126 essential low disagree review_anchor_disagreement Rv0817c 73.0 GD 1 0.74264 68.21 Strong candidate ESM-2 calibrated P(essential)=0.238; HANSEN integrated essentiality score=0.501; Mtb RBH anchor Rv0817c=essential (disagree); ProteomeLM contextual percentile=0.743; target-priority score=68.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 14 ML1617 O33015 khpA ML1617 MLCB250.30 RNA-binding protein KhpA (KH-domain protein A) 80 0.23801 non-essential 0.49311 non-essential low disagree review_anchor_disagreement Rv2908c 93.8 GD 1 0.67063 66.496 Strong candidate ESM-2 calibrated P(essential)=0.238; HANSEN integrated essentiality score=0.493; Mtb RBH anchor Rv2908c=essential (disagree); ProteomeLM contextual percentile=0.671; target-priority score=66.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 15 ML2583 Q7APT7 ML2583 Glycosyl transferase 394 0.27123 non-essential 0.48729 non-essential low disagree review_anchor_disagreement Rv0225 84.9 ES 1 0.4402 61.077 Moderate candidate ESM-2 calibrated P(essential)=0.271; HANSEN integrated essentiality score=0.487; Mtb RBH anchor Rv0225=essential (disagree); ProteomeLM contextual percentile=0.440; target-priority score=61.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 16 ML1176 P54133 ML1176 B1549_F2_59 MLCB1701.02c Uncharacterized protein ML1176 119 0.19663 non-essential 0.48435 non-essential low disagree review_anchor_disagreement Rv1342c 68.3 GD 1 0.81027 70.698 Strong candidate ESM-2 calibrated P(essential)=0.197; HANSEN integrated essentiality score=0.484; Mtb RBH anchor Rv1342c=essential (disagree); ProteomeLM contextual percentile=0.810; target-priority score=70.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 17 ML2489 Q9CB27 ML2489 Possible secreted protein 286 0.2355 non-essential 0.48055 non-essential low disagree review_anchor_disagreement Rv0383c 82.2 GD 1 0.5861 61.277 Moderate candidate ESM-2 calibrated P(essential)=0.235; HANSEN integrated essentiality score=0.481; Mtb RBH anchor Rv0383c=essential (disagree); ProteomeLM contextual percentile=0.586; target-priority score=61.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 18 ML0907 Q7AQC6 ML0907 Conserved membrane protein 377 0.28095 non-essential 0.47823 non-essential low disagree review_anchor_disagreement Rv2164c 59.8 GD 1 0.35191 48.929 Exploratory ESM-2 calibrated P(essential)=0.281; HANSEN integrated essentiality score=0.478; Mtb RBH anchor Rv2164c=essential (disagree); ProteomeLM contextual percentile=0.352; target-priority score=48.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 19 ML0888 Q7AQE1 ML0888 Polyketide cyclase / dehydrase and lipid transport 135 0.18744 non-essential 0.47786 non-essential low disagree review_anchor_disagreement Rv2186c 80.0 ES 1 0.8015 70.483 Strong candidate ESM-2 calibrated P(essential)=0.187; HANSEN integrated essentiality score=0.478; Mtb RBH anchor Rv2186c=essential (disagree); ProteomeLM contextual percentile=0.802; target-priority score=70.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 20 ML2713 P46386 rpmH ML2713 Large ribosomal subunit protein bL34 (50S ribosomal protein L34) 47 0.42684 non-essential 0.47636 non-essential medium NA medium_confidence NP_218441.1 93.6 0.64559 67.343 Strong candidate ESM-2 calibrated P(essential)=0.427; HANSEN integrated essentiality score=0.476; ProteomeLM contextual percentile=0.646; target-priority score=67.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 21 ML1720 Q9CBR0 ML1720 Pyrrolo-quinoline quinone repeat domain-containing protein 364 0.15769 non-essential 0.47063 non-essential low disagree review_anchor_disagreement Rv3035 76.0 GD 1 0.88979 74.089 Strong candidate ESM-2 calibrated P(essential)=0.158; HANSEN integrated essentiality score=0.471; Mtb RBH anchor Rv3035=essential (disagree); ProteomeLM contextual percentile=0.890; target-priority score=74.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 22 ML1026 Q7AQA9 ML1026 dUTPase 100 0.23311 non-essential 0.47017 non-essential low disagree review_anchor_disagreement Rv2699c 96.0 ES 1 0.52286 56.04 Moderate candidate ESM-2 calibrated P(essential)=0.233; HANSEN integrated essentiality score=0.470; Mtb RBH anchor Rv2699c=essential (disagree); ProteomeLM contextual percentile=0.523; target-priority score=56.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 23 ML2203 Q9CBC4 ML2203 Uncharacterized protein 373 0.19756 non-essential 0.46351 non-essential low disagree review_anchor_disagreement Rv0811c 77.4 ES 1 0.61991 65.966 Strong candidate ESM-2 calibrated P(essential)=0.198; HANSEN integrated essentiality score=0.464; Mtb RBH anchor Rv0811c=essential (disagree); ProteomeLM contextual percentile=0.620; target-priority score=66.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 24 ML2258 Q7APW7 ML2258 DUF3349 domain-containing protein 100 0.18451 non-essential 0.46138 non-essential low disagree review_anchor_disagreement Rv0543c 74.5 ES 1 0.68378 64.594 Moderate candidate ESM-2 calibrated P(essential)=0.185; HANSEN integrated essentiality score=0.461; Mtb RBH anchor Rv0543c=essential (disagree); ProteomeLM contextual percentile=0.684; target-priority score=64.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 25 ML1361 Q9CC30 ML1361 Conserved membrane protein 393 0.28398 non-essential 0.46024 non-essential low disagree review_anchor_disagreement Rv1697 90.6 ES 1 0.15028 49.637 Exploratory ESM-2 calibrated P(essential)=0.284; HANSEN integrated essentiality score=0.460; Mtb RBH anchor Rv1697=essential (disagree); ProteomeLM contextual percentile=0.150; target-priority score=49.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 26 ML0115 Q9CD99 bpa ML0115 Bacterial proteasome activator 174 0.27651 non-essential 0.45974 non-essential low disagree review_anchor_disagreement Rv3780 83.4 ES 1 0.19349 48.979 Exploratory ESM-2 calibrated P(essential)=0.277; HANSEN integrated essentiality score=0.460; Mtb RBH anchor Rv3780=essential (disagree); ProteomeLM contextual percentile=0.193; target-priority score=49.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 27 ML0211 Q7AQL6 ML0211 Carboxypeptidase 461 0.23313 non-essential 0.45811 non-essential low disagree review_anchor_disagreement Rv3627c 75.1 GD 1 0.39073 58.324 Moderate candidate ESM-2 calibrated P(essential)=0.233; HANSEN integrated essentiality score=0.458; Mtb RBH anchor Rv3627c=essential (disagree); ProteomeLM contextual percentile=0.391; target-priority score=58.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 28 ML1927 Q9CBI4 ML1927 DUF3263 domain-containing protein 102 0.23737 non-essential 0.45702 non-essential low disagree review_anchor_disagreement Rv0430 93.1 ES 1 0.37821 53.551 Moderate candidate ESM-2 calibrated P(essential)=0.237; HANSEN integrated essentiality score=0.457; Mtb RBH anchor Rv0430=essential (disagree); ProteomeLM contextual percentile=0.378; target-priority score=53.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 29 ML1809 Q9CBL8 ML1809 DUF58 domain-containing protein 320 0.25107 non-essential 0.45638 non-essential low disagree review_anchor_disagreement Rv1480 87.5 ES 1 0.29681 52.126 Moderate candidate ESM-2 calibrated P(essential)=0.251; HANSEN integrated essentiality score=0.456; Mtb RBH anchor Rv1480=essential (disagree); ProteomeLM contextual percentile=0.297; target-priority score=52.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 30 ML0611 P53530 lepA ML0611 B1937_F3_81 Elongation factor 4 (EF-4) (EC 3.6.5.n1) (Ribosomal back-translocase LepA) 646 0.42684 non-essential 0.44919 non-essential medium NA medium_confidence NP_216920.1 88.5 0.47276 71.778 Strong candidate ESM-2 calibrated P(essential)=0.427; HANSEN integrated essentiality score=0.449; ProteomeLM contextual percentile=0.473; target-priority score=71.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 31 ML1898 Q9CBK6 ML1898 Protein kinase domain-containing protein 448 0.23313 non-essential 0.44814 non-essential low disagree review_anchor_disagreement Rv0647c 85.3 ES 1 0.30557 55.406 Moderate candidate ESM-2 calibrated P(essential)=0.233; HANSEN integrated essentiality score=0.448; Mtb RBH anchor Rv0647c=essential (disagree); ProteomeLM contextual percentile=0.306; target-priority score=55.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 32 ML1723 Q9CBQ9 ML1723 Methyltransferase type 11 domain-containing protein 327 0.18438 non-essential 0.43323 non-essential low disagree review_anchor_disagreement Rv3038c 80.7 ES 1 0.42392 60.413 Moderate candidate ESM-2 calibrated P(essential)=0.184; HANSEN integrated essentiality score=0.433; Mtb RBH anchor Rv3038c=essential (disagree); ProteomeLM contextual percentile=0.424; target-priority score=60.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 33 ML1661 Q9CBS6 ML1661 MLCB1243.13 Uncharacterized protein ML1661 245 0.23815 non-essential 0.43238 non-essential low disagree review_anchor_disagreement Rv2927c 86.5 ES 1 0.16531 45.914 Exploratory ESM-2 calibrated P(essential)=0.238; HANSEN integrated essentiality score=0.432; Mtb RBH anchor Rv2927c=essential (disagree); ProteomeLM contextual percentile=0.165; target-priority score=45.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 34 ML0281 Q7AQK4 ML0281 DAGKc domain-containing protein 229 0.18003 non-essential 0.43073 non-essential low disagree review_anchor_disagreement Rv0358 62.9 GD 1 0.43832 57.758 Moderate candidate ESM-2 calibrated P(essential)=0.180; HANSEN integrated essentiality score=0.431; Mtb RBH anchor Rv0358=essential (disagree); ProteomeLM contextual percentile=0.438; target-priority score=57.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 35 ML2420 Q9CB60 hemD ML2420 Possible uroporphyrin-III C-methyltransferase 563 0.42684 non-essential 0.42762 non-essential medium NA medium_confidence YP_177733.1 85.7 0.38572 58.226 Moderate candidate ESM-2 calibrated P(essential)=0.427; HANSEN integrated essentiality score=0.428; ProteomeLM contextual percentile=0.386; target-priority score=58.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 36 ML1667 Q9CBS4 ML1667 Possible conserved membrane protein 264 0.12049 non-essential 0.42726 non-essential low disagree review_anchor_disagreement Rv2969c 66.0 ES 1 0.71822 66.287 Strong candidate ESM-2 calibrated P(essential)=0.120; HANSEN integrated essentiality score=0.427; Mtb RBH anchor Rv2969c=essential (disagree); ProteomeLM contextual percentile=0.718; target-priority score=66.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 37 ML2699 Q9CCY0 ML2699 Secreted protein 797 0.23313 non-essential 0.42465 non-essential low disagree review_anchor_disagreement Rv3909 72.3 ES 1 0.12085 45.372 Exploratory ESM-2 calibrated P(essential)=0.233; HANSEN integrated essentiality score=0.425; Mtb RBH anchor Rv3909=essential (disagree); ProteomeLM contextual percentile=0.121; target-priority score=45.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:45Z 38 ML0886 Q7AQE2 ML0886 GDP-mannose-dependent alpha-(1-6)-phosphatidylinositol monomannoside mannosyltransferase (EC 2.4.1.346) (Alpha-D-mannose-alpha-(1-6)-phosphatidylmyo-inositol-mannosyltransferase) (Alpha-mannosyltransferase) (Guanosine diphosphomannose-phosphatidyl-inositol alpha-mannosyltransferase) (Phosphatidylinositol alpha-mannosyltransferase) 384 0.38036 non-essential 0.42102 non-essential medium NA medium_confidence NP_216704.2 81.5 0.51472 73.678 Strong candidate ESM-2 calibrated P(essential)=0.380; HANSEN integrated essentiality score=0.421; ProteomeLM contextual percentile=0.515; target-priority score=73.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 39 ML1958 Q9X799 rpsD ML1958 MLCB1222.28c Small ribosomal subunit protein uS4 (30S ribosomal protein S4) 201 0.42684 non-essential 0.4209 non-essential medium NA medium_confidence NP_217975.1 93.5 0.34502 58.617 Moderate candidate ESM-2 calibrated P(essential)=0.427; HANSEN integrated essentiality score=0.421; ProteomeLM contextual percentile=0.345; target-priority score=58.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 40 ML2336 Q9CB73 ML2336 Aspartate transaminase 463 0.14132 non-essential 0.41851 non-essential low disagree review_anchor_disagreement Rv3722c 87.3 ES 1 0.51847 63.748 Moderate candidate ESM-2 calibrated P(essential)=0.141; HANSEN integrated essentiality score=0.419; Mtb RBH anchor Rv3722c=essential (disagree); ProteomeLM contextual percentile=0.518; target-priority score=63.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 41 ML1396 Q9CC20 rplT ML1396 Large ribosomal subunit protein bL20 (50S ribosomal protein L20) 129 0.42684 non-essential 0.4169 non-essential medium NA medium_confidence NP_216159.1 90.7 0.32686 56.794 Moderate candidate ESM-2 calibrated P(essential)=0.427; HANSEN integrated essentiality score=0.417; ProteomeLM contextual percentile=0.327; target-priority score=56.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 42 ML1556 Q9Z5I9 infB ML1556 MLCB596.14 Translation initiation factor IF-2 924 0.42684 non-essential 0.41339 non-essential medium NA medium_confidence NP_217355.1 80.9 0.31246 54.664 Moderate candidate ESM-2 calibrated P(essential)=0.427; HANSEN integrated essentiality score=0.413; ProteomeLM contextual percentile=0.312; target-priority score=54.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:45Z 43 ML1540 Q7AQ48 ML1540 ESX secretion-associated protein EspG 300 0.18438 non-essential 0.40726 non-essential low disagree review_anchor_disagreement Rv1794 88.0 GD 1 0.20977 51.301 Moderate candidate ESM-2 calibrated P(essential)=0.184; HANSEN integrated essentiality score=0.407; Mtb RBH anchor Rv1794=essential (disagree); ProteomeLM contextual percentile=0.210; target-priority score=51.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 44 ML1846 O32996 rpsZ rpsN ML1846 MLCB2492.17 Small ribosomal subunit protein uS14 (30S ribosomal protein S14 type Z) 61 0.28398 non-essential 0.40682 non-essential medium NA medium_confidence YP_177747.1 91.8 0.86162 77.676 Strong candidate ESM-2 calibrated P(essential)=0.284; HANSEN integrated essentiality score=0.407; ProteomeLM contextual percentile=0.862; target-priority score=77.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 45 ML1841 O33001 rpmD ML1841 MLCB2492.22 Large ribosomal subunit protein uL30 (50S ribosomal protein L30) 71 0.28398 non-essential 0.40662 non-essential medium NA medium_confidence NP_215236.1 89.2 0.86662 75.565 Strong candidate ESM-2 calibrated P(essential)=0.284; HANSEN integrated essentiality score=0.407; ProteomeLM contextual percentile=0.867; target-priority score=75.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 46 ML1652 Q7AQ34 ML1652 PucR family transcriptional regulator 414 0.16776 non-essential 0.40598 non-essential low disagree review_anchor_disagreement Rv2242 88.4 ES 1 0.28992 52.657 Moderate candidate ESM-2 calibrated P(essential)=0.168; HANSEN integrated essentiality score=0.406; Mtb RBH anchor Rv2242=essential (disagree); ProteomeLM contextual percentile=0.290; target-priority score=52.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 47 ML1045 Q9CCB2 chdC ML1045 Coproheme decarboxylase (EC 1.3.98.5) (Coproheme III oxidative decarboxylase) (Hydrogen peroxide-dependent heme synthase) 231 0.12918 non-essential 0.40467 non-essential low disagree review_anchor_disagreement Rv2676c 87.4 ES 1 0.41265 71.797 Strong candidate ESM-2 calibrated P(essential)=0.129; HANSEN integrated essentiality score=0.405; Mtb RBH anchor Rv2676c=essential (disagree); ProteomeLM contextual percentile=0.413; target-priority score=71.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 48 ML2685 P46389 rpsF ML2685 MLCB1913.21c Small ribosomal subunit protein bS6 (30S ribosomal protein S6) 96 0.28398 non-essential 0.40262 non-essential medium NA medium_confidence NP_214567.1 91.7 0.84283 75.663 Strong candidate ESM-2 calibrated P(essential)=0.284; HANSEN integrated essentiality score=0.403; ProteomeLM contextual percentile=0.843; target-priority score=75.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 49 ML2137 Q7APY6 ML2137 DUF3071 domain-containing protein 251 0.20642 non-essential 0.40143 non-essential low disagree review_anchor_disagreement Rv0883c 79.4 ES 1 0.06324 42.498 Exploratory ESM-2 calibrated P(essential)=0.206; HANSEN integrated essentiality score=0.401; Mtb RBH anchor Rv0883c=essential (disagree); ProteomeLM contextual percentile=0.063; target-priority score=42.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 50 ML0987 P35901 recA ML0987 Protein RecA (Recombinase A) [Cleaved into: Mle RecA intein] 711 0.26047 non-essential 0.39497 non-essential medium NA medium_confidence NP_217253.1 45.8 0.90169 77.034 Strong candidate ESM-2 calibrated P(essential)=0.260; HANSEN integrated essentiality score=0.395; ProteomeLM contextual percentile=0.902; target-priority score=77.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 51 ML0594 Q49682 ML0594 B1496_C1_154 MLCL536.27c u1496a Iron-sulfur cluster assembly SufBD family protein ML0594 392 0.18715 non-essential 0.39159 non-essential low disagree review_anchor_disagreement Rv1462 81.3 ES 1 0.06074 46.447 Exploratory ESM-2 calibrated P(essential)=0.187; HANSEN integrated essentiality score=0.392; Mtb RBH anchor Rv1462=essential (disagree); ProteomeLM contextual percentile=0.061; target-priority score=46.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 52 ML1962 P0A5H7 infA ML1962 Translation initiation factor IF-1 73 0.42684 non-essential 0.3857 non-essential medium NA medium_confidence NP_217979.1 100.0 0.16218 50.381 Moderate candidate ESM-2 calibrated P(essential)=0.427; HANSEN integrated essentiality score=0.386; ProteomeLM contextual percentile=0.162; target-priority score=50.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 53 ML1937 Q9CBI0 ML1937 Probable integral membrane protein 410 0.0186 non-essential 0.38566 non-essential low disagree review_anchor_disagreement Rv1111c 45.3 ESD 1 0.89981 69.037 Strong candidate ESM-2 calibrated P(essential)=0.019; HANSEN integrated essentiality score=0.386; Mtb RBH anchor Rv1111c=essential (disagree); ProteomeLM contextual percentile=0.900; target-priority score=69.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 54 ML1854 O32990 rpsQ ML1854 MLCB2492.11 Small ribosomal subunit protein uS17 (30S ribosomal protein S17) 126 0.25141 non-essential 0.38554 non-essential medium NA medium_confidence NP_215224.1 77.2 0.89167 75.711 Strong candidate ESM-2 calibrated P(essential)=0.251; HANSEN integrated essentiality score=0.386; ProteomeLM contextual percentile=0.892; target-priority score=75.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 55 ML1877 P30768 tuf ML1877 Elongation factor Tu (EF-Tu) (EC 3.6.5.3) 396 0.42684 non-essential 0.38167 non-essential medium NA medium_confidence NP_215199.1 95.2 0.11584 58.087 Moderate candidate ESM-2 calibrated P(essential)=0.427; HANSEN integrated essentiality score=0.382; ProteomeLM contextual percentile=0.116; target-priority score=58.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 56 ML0229 Q7AQL2 ML0229 Oxidoreductase 309 0.00674 non-essential 0.37935 non-essential low disagree review_anchor_disagreement Rv3603c 67.8 ESD 1 0.88416 73.776 Strong candidate ESM-2 calibrated P(essential)=0.007; HANSEN integrated essentiality score=0.379; Mtb RBH anchor Rv3603c=essential (disagree); ProteomeLM contextual percentile=0.884; target-priority score=73.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 57 ML0257 Q9CD40 ML0257 Septum formation initiator subfamily protein 167 0.0873 non-essential 0.37569 non-essential low disagree review_anchor_disagreement Rv1025 85.1 ES 1 0.44083 58.46 Moderate candidate ESM-2 calibrated P(essential)=0.087; HANSEN integrated essentiality score=0.376; Mtb RBH anchor Rv1025=essential (disagree); ProteomeLM contextual percentile=0.441; target-priority score=58.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 58 ML2428 P0A5D0 rpsW ML2428.1 ML2428A Small ribosomal subunit protein bS22 33 0.42684 non-essential 0.37311 non-essential medium NA medium_confidence 0.10269 45.441 Exploratory ESM-2 calibrated P(essential)=0.427; HANSEN integrated essentiality score=0.373; ProteomeLM contextual percentile=0.103; target-priority score=45.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 59 ML1957 Q9X798 rpoA ML1957 MLCB1222.27c DNA-directed RNA polymerase subunit alpha (RNAP subunit alpha) (EC 2.7.7.6) (RNA polymerase subunit alpha) (Transcriptase subunit alpha) 347 0.42684 non-essential 0.36985 non-essential medium NA medium_confidence NP_217974.1 95.7 0.05698 54.459 Moderate candidate ESM-2 calibrated P(essential)=0.427; HANSEN integrated essentiality score=0.370; ProteomeLM contextual percentile=0.057; target-priority score=54.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 60 ML1844 O32998 rplF ML1844 MLCB2492.19 Large ribosomal subunit protein uL6 (50S ribosomal protein L6) 179 0.42684 non-essential 0.3698 non-essential medium NA medium_confidence NP_215233.1 90.5 0.07138 49.468 Exploratory ESM-2 calibrated P(essential)=0.427; HANSEN integrated essentiality score=0.370; ProteomeLM contextual percentile=0.071; target-priority score=49.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 61 ML1880 P30766 rpsL ML1880 Small ribosomal subunit protein uS12 (30S ribosomal protein S12) 124 0.42684 non-essential 0.36133 non-essential medium NA medium_confidence NP_215196.1 97.6 0.02943 46.785 Exploratory ESM-2 calibrated P(essential)=0.427; HANSEN integrated essentiality score=0.361; ProteomeLM contextual percentile=0.029; target-priority score=46.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 62 ML0730 Q7AQF7 ML0730 ML0730 protein 84 0.24476 non-essential 0.35954 non-essential medium NA medium_confidence NP_217798.1 80.3 0.79649 66.44 Strong candidate ESM-2 calibrated P(essential)=0.245; HANSEN integrated essentiality score=0.360; ProteomeLM contextual percentile=0.796; target-priority score=66.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 63 ML1860 O32984 rplB ML1860 MLCB2492.05 Large ribosomal subunit protein uL2 (50S ribosomal protein L2) 280 0.42077 non-essential 0.35578 non-essential medium NA medium_confidence NP_215218.1 92.1 0.02442 46.866 Exploratory ESM-2 calibrated P(essential)=0.421; HANSEN integrated essentiality score=0.356; ProteomeLM contextual percentile=0.024; target-priority score=46.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 64 ML1467 Q9CBZ2 rplU ML1467 Large ribosomal subunit protein bL21 (50S ribosomal protein L21) 103 0.28398 non-essential 0.35305 non-essential medium NA medium_confidence NP_216958.1 91.2 0.57984 65.937 Strong candidate ESM-2 calibrated P(essential)=0.284; HANSEN integrated essentiality score=0.353; ProteomeLM contextual percentile=0.580; target-priority score=65.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 65 ML1683 O33125 hupB hlp lbp21 ML1683 MLCB637.34 DNA-binding protein HupB (HupB) (EC 1.16.3.1) (21 kDa laminin-2-binding protein) (ML-LBP21) (DNA-binding protein HU homolog) (Histone-like protein) (Hlp) 200 0.2301 non-essential 0.35066 non-essential medium NA medium_confidence NP_217502.1 96.5 0.78272 76.235 Strong candidate ESM-2 calibrated P(essential)=0.230; HANSEN integrated essentiality score=0.351; ProteomeLM contextual percentile=0.783; target-priority score=76.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 66 ML0697 Q9CCM1 sdhA ML0697 Succinate dehydrogenase flavoprotein subunit (EC 1.3.5.1) 584 0.23815 non-essential 0.34636 non-essential medium NA medium_confidence NP_217835.1 92.7 0.70445 81.686 High-priority ESM-2 calibrated P(essential)=0.238; HANSEN integrated essentiality score=0.346; ProteomeLM contextual percentile=0.704; target-priority score=81.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 67 ML0006 Q57532 gyrA ML0006 DNA gyrase subunit A (EC 5.6.2.2) [Cleaved into: Mle GyrA intein] 1273 0.2107 non-essential 0.34408 non-essential medium NA medium_confidence NP_214520.1 60.6 0.81528 82.265 High-priority ESM-2 calibrated P(essential)=0.211; HANSEN integrated essentiality score=0.344; ProteomeLM contextual percentile=0.815; target-priority score=82.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:45Z 68 ML1663 O69466 coaD kdtB ML1663 MLCB1243.10 Phosphopantetheine adenylyltransferase (EC 2.7.7.3) (Dephospho-CoA pyrophosphorylase) (Pantetheine-phosphate adenylyltransferase) (PPAT) 160 0.23815 non-essential 0.34172 non-essential medium NA medium_confidence NP_217481.1 84.1 0.67815 81.365 High-priority ESM-2 calibrated P(essential)=0.238; HANSEN integrated essentiality score=0.342; ProteomeLM contextual percentile=0.678; target-priority score=81.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 69 ML1858 O32986 rplV ML1858 MLCB2492.07 Large ribosomal subunit protein uL22 (50S ribosomal protein L22) 175 0.23313 non-essential 0.34142 non-essential medium NA medium_confidence NP_215220.1 89.8 0.732 70.286 Strong candidate ESM-2 calibrated P(essential)=0.233; HANSEN integrated essentiality score=0.341; ProteomeLM contextual percentile=0.732; target-priority score=70.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 70 ML1145 P45823 atpD ML1145 ATP synthase subunit beta (EC 7.1.2.2) (ATP synthase F1 sector subunit beta) (F-ATPase subunit beta) 485 0.37988 non-essential 0.33887 non-essential medium NA medium_confidence NP_215826.1 94.1 0.08265 57.038 Moderate candidate ESM-2 calibrated P(essential)=0.380; HANSEN integrated essentiality score=0.339; ProteomeLM contextual percentile=0.083; target-priority score=57.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 71 ML1960 Q9X7A1 rpsM ML1960 MLCB1222.30c Small ribosomal subunit protein uS13 (30S ribosomal protein S13) 124 0.28398 non-essential 0.33329 non-essential medium NA medium_confidence NP_217977.1 92.7 0.47527 61.979 Moderate candidate ESM-2 calibrated P(essential)=0.284; HANSEN integrated essentiality score=0.333; ProteomeLM contextual percentile=0.475; target-priority score=62.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 72 ML1956 Q9X797 rplQ ML1956 MLCB1222.26c Large ribosomal subunit protein bL17 (50S ribosomal protein L17) 170 0.23313 non-essential 0.3315 non-essential medium NA medium_confidence NP_217973.1 92.0 0.67877 68.543 Strong candidate ESM-2 calibrated P(essential)=0.233; HANSEN integrated essentiality score=0.332; ProteomeLM contextual percentile=0.679; target-priority score=68.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 73 ML1468 Q9CBZ1 ML1468 Ribonuclease E (EC 3.1.26.12) 924 0.38101 non-essential 0.32861 non-essential medium NA medium_confidence NP_216960.1 76.5 0.04321 48.153 Exploratory ESM-2 calibrated P(essential)=0.381; HANSEN integrated essentiality score=0.329; ProteomeLM contextual percentile=0.043; target-priority score=48.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:45Z 74 ML0124 Q9CD92 ML0124 Coenzyme Q-binding protein COQ10 START domain-containing protein 146 0.20924 non-essential 0.32776 non-essential medium NA medium_confidence 0.76018 70.644 Strong candidate ESM-2 calibrated P(essential)=0.209; HANSEN integrated essentiality score=0.328; ProteomeLM contextual percentile=0.760; target-priority score=70.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 75 ML1843 O32999 rplR ML1843 MLCB2492.20 Large ribosomal subunit protein uL18 (50S ribosomal protein L18) 122 0.28398 non-essential 0.32406 non-essential medium NA medium_confidence NP_215234.1 82.8 0.42267 61.401 Moderate candidate ESM-2 calibrated P(essential)=0.284; HANSEN integrated essentiality score=0.324; ProteomeLM contextual percentile=0.423; target-priority score=61.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 76 ML1321 Q9ZBE0 pup ML1321 MLCB2533.18 Prokaryotic ubiquitin-like protein Pup (Bacterial ubiquitin-like modifier) 63 0.15606 non-essential 0.32279 non-essential high NA medium_confidence NP_216627.1 84.4 0.95492 77.448 Strong candidate ESM-2 calibrated P(essential)=0.156; HANSEN integrated essentiality score=0.323; ProteomeLM contextual percentile=0.955; target-priority score=77.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 77 ML1144 P45824 atpG ML1144 ATP synthase gamma chain (ATP synthase F1 sector gamma subunit) (F-ATPase gamma subunit) 298 0.38101 non-essential 0.32274 non-essential medium NA medium_confidence NP_215825.1 83.9 0.01315 46.644 Exploratory ESM-2 calibrated P(essential)=0.381; HANSEN integrated essentiality score=0.323; ProteomeLM contextual percentile=0.013; target-priority score=46.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 78 ML1842 O33000 rpsE ML1842 MLCB2492.21 Small ribosomal subunit protein uS5 (30S ribosomal protein S5) 217 0.20275 non-essential 0.32157 non-essential medium NA medium_confidence NP_215235.1 87.4 0.75204 71.151 Strong candidate ESM-2 calibrated P(essential)=0.203; HANSEN integrated essentiality score=0.322; ProteomeLM contextual percentile=0.752; target-priority score=71.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 79 ML0009 Q9CDF0 ML0009 Uncharacterized protein 63 0.14578 non-essential 0.31852 non-essential high NA medium_confidence 0.99186 72.395 Strong candidate ESM-2 calibrated P(essential)=0.146; HANSEN integrated essentiality score=0.319; ProteomeLM contextual percentile=0.992; target-priority score=72.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 80 ML0922 P46815 wag31 ag84 ML0922 Cell wall synthesis protein Wag31 (Antigen 84) 266 0.19217 non-essential 0.31839 non-essential high NA medium_confidence NP_216661.1 86.5 0.78585 69.794 Strong candidate ESM-2 calibrated P(essential)=0.192; HANSEN integrated essentiality score=0.318; ProteomeLM contextual percentile=0.786; target-priority score=69.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 81 ML1613 O33020 rplS ML1613 MLCB250.38 Large ribosomal subunit protein bL19 (50S ribosomal protein L19) 113 0.28398 non-essential 0.3159 non-essential medium NA medium_confidence NP_217420.1 93.8 0.38384 58.287 Moderate candidate ESM-2 calibrated P(essential)=0.284; HANSEN integrated essentiality score=0.316; ProteomeLM contextual percentile=0.384; target-priority score=58.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 82 ML2189 Q50046 pstB phoT ML2189 Phosphate import ATP-binding protein PstB (EC 7.3.2.1) (ABC phosphate transporter) (Phosphate-transporting ATPase) 258 0.23805 non-essential 0.31413 non-essential medium NA medium_confidence NP_215335.1 91.9 0.54164 72.734 Strong candidate ESM-2 calibrated P(essential)=0.238; HANSEN integrated essentiality score=0.314; ProteomeLM contextual percentile=0.542; target-priority score=72.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 83 ML1517 Q9CBW2 ML1517 Uncharacterized protein 93 0.15015 non-essential 0.3122 non-essential high NA medium_confidence 0.93425 72.517 Strong candidate ESM-2 calibrated P(essential)=0.150; HANSEN integrated essentiality score=0.312; ProteomeLM contextual percentile=0.934; target-priority score=72.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 84 ML2219 O05756 purQ ML2219 Phosphoribosylformylglycinamidine synthase subunit PurQ (FGAM synthase) (EC 6.3.5.3) (Formylglycinamide ribonucleotide amidotransferase subunit I) (FGAR amidotransferase I) (FGAR-AT I) (Glutaminase PurQ) (EC 3.5.1.2) (Phosphoribosylformylglycinamidine synthase subunit I) 224 0.19882 non-essential 0.30855 non-essential high NA medium_confidence NP_215303.1 89.2 0.66688 80.194 High-priority ESM-2 calibrated P(essential)=0.199; HANSEN integrated essentiality score=0.309; ProteomeLM contextual percentile=0.667; target-priority score=80.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 85 ML2307 Q9CB86 whiB ML2307 Transcriptional regulator WhiB 81 0.23801 non-essential 0.30809 non-essential medium NA medium_confidence NP_218198.2 88.5 0.52599 66.063 Strong candidate ESM-2 calibrated P(essential)=0.238; HANSEN integrated essentiality score=0.308; ProteomeLM contextual percentile=0.526; target-priority score=66.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 86 ML1384 Q9CC28 ML1384 Uncharacterized protein 112 0.13675 non-essential 0.30621 non-essential high NA medium_confidence 0.96807 69.938 Strong candidate ESM-2 calibrated P(essential)=0.137; HANSEN integrated essentiality score=0.306; ProteomeLM contextual percentile=0.968; target-priority score=69.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 87 ML1735 Q9CBP9 nrdI ML1735 Protein NrdI 138 0.18427 non-essential 0.30264 non-essential high NA medium_confidence NP_217568.1 82.7 0.72949 69.803 Strong candidate ESM-2 calibrated P(essential)=0.184; HANSEN integrated essentiality score=0.303; ProteomeLM contextual percentile=0.729; target-priority score=69.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 88 ML0977 O05560 ftsK ML0977 MLCB33.09c DNA translocase FtsK 840 0.19217 non-essential 0.29924 non-essential high NA medium_confidence NP_217264.1 80.4 0.67564 68.976 Strong candidate ESM-2 calibrated P(essential)=0.192; HANSEN integrated essentiality score=0.299; ProteomeLM contextual percentile=0.676; target-priority score=69.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:45Z 89 ML0228 Q7AQL3 ML0228 Membrane protein 432 0.14724 non-essential 0.29923 non-essential high NA medium_confidence NP_218121.2 53.4 0.88541 67.725 Strong candidate ESM-2 calibrated P(essential)=0.147; HANSEN integrated essentiality score=0.299; ProteomeLM contextual percentile=0.885; target-priority score=67.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 90 ML0024 Q9CDE2 ML0024 Uncharacterized protein 83 0.14132 non-essential 0.29885 non-essential high NA medium_confidence 0.90733 68.755 Strong candidate ESM-2 calibrated P(essential)=0.141; HANSEN integrated essentiality score=0.299; ProteomeLM contextual percentile=0.907; target-priority score=68.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 91 ML1878 P30767 fusA efg ML1878 Elongation factor G (EF-G) 701 0.20941 non-essential 0.29565 non-essential medium NA medium_confidence YP_177746.1 90.4 0.57796 68.112 Strong candidate ESM-2 calibrated P(essential)=0.209; HANSEN integrated essentiality score=0.296; ProteomeLM contextual percentile=0.578; target-priority score=68.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 92 ML0388 Q49721 ML0388 B1620_C2_193 Uncharacterized oxidoreductase ML0388 (EC 1.-.-.-) 375 0.19217 non-essential 0.29473 non-essential high NA medium_confidence NP_217927.1 90.6 0.6412 71.659 Strong candidate ESM-2 calibrated P(essential)=0.192; HANSEN integrated essentiality score=0.295; ProteomeLM contextual percentile=0.641; target-priority score=71.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 93 ML1674 P68998 rpmB ML1674 Large ribosomal subunit protein bL28 (50S ribosomal protein L28) 64 0.23313 non-essential 0.29184 non-essential medium NA medium_confidence YP_009030042.1 90.6 0.5 ESM-2 calibrated P(essential)=0.233; HANSEN integrated essentiality score=0.292; ProteomeLM contextual percentile=0.500 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 94 ML1990 Q9CBG6 ML1990 Integral membrane protein 80 0.11105 non-essential 0.29096 non-essential high NA medium_confidence 0.9881 72.731 Strong candidate ESM-2 calibrated P(essential)=0.111; HANSEN integrated essentiality score=0.291; ProteomeLM contextual percentile=0.988; target-priority score=72.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 95 ML2712 P46610 rnpA ML2712 Ribonuclease P protein component (RNase P protein) (RNaseP protein) (EC 3.1.26.5) (Protein C5) 120 0.17588 non-essential 0.29075 non-essential high NA medium_confidence NP_218440.3 63.0 0.68253 75.065 Strong candidate ESM-2 calibrated P(essential)=0.176; HANSEN integrated essentiality score=0.291; ProteomeLM contextual percentile=0.683; target-priority score=75.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 96 ML1498 Q9CBX2 bipA ML1498 Large ribosomal subunit assembly factor BipA (EC 3.6.5.-) (GTP-binding protein BipA) 628 0.2488 non-essential 0.29051 non-essential medium NA medium_confidence NP_215681.1 84.9 0.36694 68.146 Strong candidate ESM-2 calibrated P(essential)=0.249; HANSEN integrated essentiality score=0.291; ProteomeLM contextual percentile=0.367; target-priority score=68.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 97 ML0183 Q7AQM7 moeA ML0183 Molybdopterin molybdenumtransferase (EC 2.10.1.1) 424 0.22459 non-essential 0.29015 non-essential medium NA medium_confidence YP_177776.1 88.5 0.46713 71.108 Strong candidate ESM-2 calibrated P(essential)=0.225; HANSEN integrated essentiality score=0.290; ProteomeLM contextual percentile=0.467; target-priority score=71.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 98 ML1022 Q7AQB1 rpoT sigA ML1022 RNA polymerase sigma factor SigA 574 0.21287 non-essential 0.28998 non-essential medium NA medium_confidence NP_217219.1 74.4 0.54978 60.943 Moderate candidate ESM-2 calibrated P(essential)=0.213; HANSEN integrated essentiality score=0.290; ProteomeLM contextual percentile=0.550; target-priority score=60.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 99 ML1392 Q9CC24 uvrA ML1392 UvrABC system protein A (UvrA protein) (Excinuclease ABC subunit A) 969 0.19217 non-essential 0.28677 non-essential high NA medium_confidence NP_216154.1 90.5 0.60864 66.82 Strong candidate ESM-2 calibrated P(essential)=0.192; HANSEN integrated essentiality score=0.287; ProteomeLM contextual percentile=0.609; target-priority score=66.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:45Z 100 ML1711 O33096 etfA fixB ML1711 MLCB637.04 Electron transfer flavoprotein subunit alpha (Alpha-ETF) (Electron transfer flavoprotein large subunit) (ETFLS) 318 0.19217 non-essential 0.28572 non-essential high NA medium_confidence NP_217544.1 84.9 0.59737 68.54 Strong candidate ESM-2 calibrated P(essential)=0.192; HANSEN integrated essentiality score=0.286; ProteomeLM contextual percentile=0.597; target-priority score=68.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 101 ML0133 Q9CD83 ML0133 Chorismate pyruvate-lyase (EC 4.1.3.40) (4-HB synthase) (p-hydroxybenzoic acid synthase) 210 0.13377 non-essential 0.28428 non-essential high NA medium_confidence NP_217465.1 62.6 0.82592 79.071 Strong candidate ESM-2 calibrated P(essential)=0.134; HANSEN integrated essentiality score=0.284; ProteomeLM contextual percentile=0.826; target-priority score=79.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 102 ML0022 Q9CDE4 ML0022 FHA domain-containing protein 488 0.14503 non-essential 0.2835 non-essential high NA medium_confidence NP_214534.1 62.8 0.80776 66.124 Strong candidate ESM-2 calibrated P(essential)=0.145; HANSEN integrated essentiality score=0.284; ProteomeLM contextual percentile=0.808; target-priority score=66.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 103 ML0670 O32882 ftsX ML0670 MLCB1779.20c Cell division protein FtsX 297 0.19217 non-essential 0.28098 non-essential high NA medium_confidence NP_217617.1 81.1 0.57921 65.231 Strong candidate ESM-2 calibrated P(essential)=0.192; HANSEN integrated essentiality score=0.281; ProteomeLM contextual percentile=0.579; target-priority score=65.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 104 ML2478 Q9CB30 ML2478 Uncharacterized protein 129 0.0998 non-essential 0.28095 non-essential high NA medium_confidence 0.98184 72.387 Strong candidate ESM-2 calibrated P(essential)=0.100; HANSEN integrated essentiality score=0.281; ProteomeLM contextual percentile=0.982; target-priority score=72.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 105 ML2530 Q9CD34 ML2530 Possible DNA-binding protein 289 0.21735 non-essential 0.27819 non-essential medium NA medium_confidence NP_214803.1 75.9 0.46274 59.988 Moderate candidate ESM-2 calibrated P(essential)=0.217; HANSEN integrated essentiality score=0.278; ProteomeLM contextual percentile=0.463; target-priority score=60.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 106 ML1370 O05668 ML1370 MLCB1351.03c u0247g Uncharacterized RNA pseudouridine synthase ML1370 (EC 5.4.99.-) (RNA pseudouridylate synthase) (RNA-uridine isomerase) 256 0.23801 non-essential 0.27748 non-essential medium NA medium_confidence NP_216227.1 80.5 0.34753 65.513 Strong candidate ESM-2 calibrated P(essential)=0.238; HANSEN integrated essentiality score=0.277; ProteomeLM contextual percentile=0.348; target-priority score=65.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 107 ML1879 P30764 rpsG ML1879 Small ribosomal subunit protein uS7 (30S ribosomal protein S7) 156 0.1873 non-essential 0.27732 non-essential high NA medium_confidence NP_215197.1 96.8 0.57483 67.015 Strong candidate ESM-2 calibrated P(essential)=0.187; HANSEN integrated essentiality score=0.277; ProteomeLM contextual percentile=0.575; target-priority score=67.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 108 ML1861 O32983 rplW ML1861 MLCB2492.04 Large ribosomal subunit protein uL23 (50S ribosomal protein L23) 100 0.28398 non-essential 0.27654 non-essential medium NA medium_confidence NP_215217.1 85.0 0.17282 51.308 Moderate candidate ESM-2 calibrated P(essential)=0.284; HANSEN integrated essentiality score=0.277; ProteomeLM contextual percentile=0.173; target-priority score=51.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 109 ML0855 O32965 ML0855 MLCB22.26c Uncharacterized zinc protease ML0855 (EC 3.4.24.-) 445 0.20518 non-essential 0.27599 non-essential medium NA medium_confidence NP_217298.1 84.1 0.4809 68.384 Strong candidate ESM-2 calibrated P(essential)=0.205; HANSEN integrated essentiality score=0.276; ProteomeLM contextual percentile=0.481; target-priority score=68.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 110 ML1892 P30769 mkl ML1892 Probable ribonucleotide transport ATP-binding protein mkl 347 0.1873 non-essential 0.27585 non-essential high NA medium_confidence NP_215169.1 93.2 0.56794 66.417 Strong candidate ESM-2 calibrated P(essential)=0.187; HANSEN integrated essentiality score=0.276; ProteomeLM contextual percentile=0.568; target-priority score=66.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 111 ML2527 Q9CD37 ML2527 Conserved membrane protein 339 0.14724 non-essential 0.27575 non-essential high NA medium_confidence NP_214806.1 59.9 0.74389 68.879 Strong candidate ESM-2 calibrated P(essential)=0.147; HANSEN integrated essentiality score=0.276; ProteomeLM contextual percentile=0.744; target-priority score=68.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 112 ML1856 O32988 rplP ML1856 MLCB2492.09 Large ribosomal subunit protein uL16 (50S ribosomal protein L16) 138 0.23313 non-essential 0.27532 non-essential medium NA medium_confidence NP_215222.1 96.4 0.37633 59.005 Moderate candidate ESM-2 calibrated P(essential)=0.233; HANSEN integrated essentiality score=0.275; ProteomeLM contextual percentile=0.376; target-priority score=59.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 113 ML1543 Q7AQ47 ML1543 Possible SpoIIIE-family membrane protein 1345 0.13986 non-essential 0.27516 non-essential high NA medium_confidence YP_007410461.1 87.3 0.76894 70.691 Strong candidate ESM-2 calibrated P(essential)=0.140; HANSEN integrated essentiality score=0.275; ProteomeLM contextual percentile=0.769; target-priority score=70.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:45Z 114 ML1263 Q9X7C2 hisF ML1263 MLCB1610.26 Imidazole glycerol phosphate synthase subunit HisF (EC 4.3.2.10) (IGP synthase cyclase subunit) (IGP synthase subunit HisF) (ImGP synthase subunit HisF) (IGPS subunit HisF) 261 0.18867 non-essential 0.27499 non-essential high NA medium_confidence NP_216121.1 88.8 0.531 75.113 Strong candidate ESM-2 calibrated P(essential)=0.189; HANSEN integrated essentiality score=0.275; ProteomeLM contextual percentile=0.531; target-priority score=75.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 115 ML0247 Q9CD46 arsC ML0247 Arsenate reductase 104 0.10085 non-essential 0.27433 non-essential high NA medium_confidence 0.93488 73.468 Strong candidate ESM-2 calibrated P(essential)=0.101; HANSEN integrated essentiality score=0.274; ProteomeLM contextual percentile=0.935; target-priority score=73.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 116 ML0802 Q9CCH9 ML0802 Biotinylated protein TB7.3 homolog 71 0.13353 non-essential 0.27416 non-essential high NA medium_confidence Rv3221c 93.2 UNCERTAIN 0.79587 69.422 Strong candidate ESM-2 calibrated P(essential)=0.134; HANSEN integrated essentiality score=0.274; ProteomeLM contextual percentile=0.796; target-priority score=69.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 117 ML2170 Q9CBD5 ML2170 Uncharacterized protein 74 0.09928 non-essential 0.27391 non-essential high NA medium_confidence 0.94928 70.189 Strong candidate ESM-2 calibrated P(essential)=0.099; HANSEN integrated essentiality score=0.274; ProteomeLM contextual percentile=0.949; target-priority score=70.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 118 ML1618 O33014 rpsP ML1618 MLCB250.32 Small ribosomal subunit protein bS16 (30S ribosomal protein S16) 160 0.14132 non-essential 0.27362 non-essential high NA medium_confidence NP_217425.1 90.9 0.75329 70.671 Strong candidate ESM-2 calibrated P(essential)=0.141; HANSEN integrated essentiality score=0.274; ProteomeLM contextual percentile=0.753; target-priority score=70.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 119 ML1855 O32989 rpmC ML1855 MLCB2492.10 Large ribosomal subunit protein uL29 (50S ribosomal protein L29) 80 0.1367 non-essential 0.27309 non-essential high NA medium_confidence NP_215223.1 91.9 0.76769 71.9 Strong candidate ESM-2 calibrated P(essential)=0.137; HANSEN integrated essentiality score=0.273; ProteomeLM contextual percentile=0.768; target-priority score=71.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 120 ML2177 Q9CBD1 ML2177 Uridine phosphorylase (EC 2.4.2.3) 317 0.10418 non-essential 0.27308 non-essential high NA medium_confidence 0.88604 82.389 High-priority ESM-2 calibrated P(essential)=0.104; HANSEN integrated essentiality score=0.273; ProteomeLM contextual percentile=0.886; target-priority score=82.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 121 ML0142 Q9CD76 ML0142 Possible membrane protein 82 0.09201 non-essential 0.27301 non-essential high NA medium_confidence 0.97182 72.071 Strong candidate ESM-2 calibrated P(essential)=0.092; HANSEN integrated essentiality score=0.273; ProteomeLM contextual percentile=0.972; target-priority score=72.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 122 ML0522 Q9CCS0 efp ML0522 Elongation factor P (EF-P) 187 0.13353 non-essential 0.27297 non-essential high NA medium_confidence NP_217050.1 94.1 0.77207 75.143 Strong candidate ESM-2 calibrated P(essential)=0.134; HANSEN integrated essentiality score=0.273; ProteomeLM contextual percentile=0.772; target-priority score=75.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 123 ML1466 Q9CBZ3 rpmA ML1466 Large ribosomal subunit protein bL27 (50S ribosomal protein L27) 88 0.13353 non-essential 0.27236 non-essential high NA medium_confidence NP_216957.1 93.8 0.77771 72.001 Strong candidate ESM-2 calibrated P(essential)=0.134; HANSEN integrated essentiality score=0.272; ProteomeLM contextual percentile=0.778; target-priority score=72.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 124 ML1849 O32993 rplN ML1849 MLCB2492.14 Large ribosomal subunit protein uL14 (50S ribosomal protein L14) 122 0.1873 non-essential 0.27181 non-essential high NA medium_confidence NP_215228.1 96.7 0.54415 66.421 Strong candidate ESM-2 calibrated P(essential)=0.187; HANSEN integrated essentiality score=0.272; ProteomeLM contextual percentile=0.544; target-priority score=66.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 125 ML1695 O33113 ilvH ilvN ML1695 MLCB637.21 Acetolactate synthase small subunit (EC 2.2.1.6) (Acetohydroxy-acid synthase small subunit) (AHAS) (ALS) 169 0.18715 non-essential 0.27156 non-essential high NA medium_confidence NP_217518.1 83.5 0.52473 72.76 Strong candidate ESM-2 calibrated P(essential)=0.187; HANSEN integrated essentiality score=0.272; ProteomeLM contextual percentile=0.525; target-priority score=72.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 126 ML2300 Q9CB93 ML2300 Membrane protein 215 0.14132 non-essential 0.27096 non-essential high NA medium_confidence NP_218190.1 71.9 0.73638 71.098 Strong candidate ESM-2 calibrated P(essential)=0.141; HANSEN integrated essentiality score=0.271; ProteomeLM contextual percentile=0.736; target-priority score=71.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 127 ML0947 Q9CCD2 ML0947 Uncharacterized protein 85 0.09638 non-essential 0.27072 non-essential high NA medium_confidence 0.9449 69.815 Strong candidate ESM-2 calibrated P(essential)=0.096; HANSEN integrated essentiality score=0.271; ProteomeLM contextual percentile=0.945; target-priority score=69.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 128 ML0542 Q9CCQ6 rpoZ ML0542 DNA-directed RNA polymerase subunit omega (RNAP omega subunit) (EC 2.7.7.6) (RNA polymerase omega subunit) (Transcriptase subunit omega) 110 0.15015 non-essential 0.27071 non-essential high NA medium_confidence NP_215906.1 90.9 0.68754 73.425 Strong candidate ESM-2 calibrated P(essential)=0.150; HANSEN integrated essentiality score=0.271; ProteomeLM contextual percentile=0.688; target-priority score=73.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 129 ML0640 Q9CCM8 ML0640 ABC1 atypical kinase-like domain-containing protein 473 0.14132 non-essential 0.27026 non-essential high NA medium_confidence NP_217713.1 83.0 0.73701 69.476 Strong candidate ESM-2 calibrated P(essential)=0.141; HANSEN integrated essentiality score=0.270; ProteomeLM contextual percentile=0.737; target-priority score=69.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 130 ML0796 Q7AQF5 ML0796 Uncharacterized protein 58 0.08711 non-essential 0.27013 non-essential high NA medium_confidence 0.97621 72.451 Strong candidate ESM-2 calibrated P(essential)=0.087; HANSEN integrated essentiality score=0.270; ProteomeLM contextual percentile=0.976; target-priority score=72.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 131 ML1307 Q49775 metH ML1307 B2126_C1_157 MLCB2533.04 Methionine synthase (EC 2.1.1.13) (5-methyltetrahydrofolate--homocysteine methyltransferase) (Methionine synthase, vitamin-B12 dependent) (MS) 1206 0.28398 non-essential 0.27009 non-essential medium NA medium_confidence NP_216640.1 88.1 0.10958 59.906 Moderate candidate ESM-2 calibrated P(essential)=0.284; HANSEN integrated essentiality score=0.270; ProteomeLM contextual percentile=0.110; target-priority score=59.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:45Z 132 ML1985 P46831 aceA ML1985 Isocitrate lyase (ICL) (EC 4.1.3.1) (Isocitrase) (Isocitratase) 606 0.09948 non-essential 0.26805 non-essential high NA medium_confidence NP_216431.1 87.1 0.86475 86.899 High-priority ESM-2 calibrated P(essential)=0.099; HANSEN integrated essentiality score=0.268; ProteomeLM contextual percentile=0.865; target-priority score=86.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 133 ML0162 Q7AQN3 ML0162 Uncharacterized protein 92 0.09148 non-essential 0.26646 non-essential high NA medium_confidence 0.94239 69.789 Strong candidate ESM-2 calibrated P(essential)=0.091; HANSEN integrated essentiality score=0.266; ProteomeLM contextual percentile=0.942; target-priority score=69.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 134 ML0298 Q7AQK0 ML0298 Thiamine biosynthesis protein ThiS 74 0.10418 non-essential 0.26616 non-essential high NA medium_confidence NP_214930.1 71.6 0.87602 71.953 Strong candidate ESM-2 calibrated P(essential)=0.104; HANSEN integrated essentiality score=0.266; ProteomeLM contextual percentile=0.876; target-priority score=72.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 135 ML1199 Q9X7E7 lspA ML1199 MLCB458.14 Lipoprotein signal peptidase (EC 3.4.23.36) (Prolipoprotein signal peptidase) (Signal peptidase II) (SPase II) 201 0.10418 non-essential 0.26585 non-essential high NA medium_confidence NP_216055.1 82.2 0.83469 85.386 High-priority ESM-2 calibrated P(essential)=0.104; HANSEN integrated essentiality score=0.266; ProteomeLM contextual percentile=0.835; target-priority score=85.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 136 ML1857 O32987 rpsC ML1857 MLCB2492.08 Small ribosomal subunit protein uS3 (30S ribosomal protein S3) 281 0.23815 non-essential 0.26554 non-essential medium NA medium_confidence NP_215221.1 96.1 0.30745 55.031 Moderate candidate ESM-2 calibrated P(essential)=0.238; HANSEN integrated essentiality score=0.266; ProteomeLM contextual percentile=0.307; target-priority score=55.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 137 ML0217 Q9CD59 ML0217 Uncharacterized protein 81 0.08936 non-essential 0.26474 non-essential high NA medium_confidence 0.94114 70.098 Strong candidate ESM-2 calibrated P(essential)=0.089; HANSEN integrated essentiality score=0.265; ProteomeLM contextual percentile=0.941; target-priority score=70.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 138 ML1141 P45827 atpF ML1141 ATP synthase subunit b (ATP synthase F(0) sector subunit b) (ATPase subunit I) (F-type ATPase subunit b) (F-ATPase subunit b) 170 0.11857 non-essential 0.2637 non-essential high NA medium_confidence NP_215822.1 79.5 0.80025 70.334 Strong candidate ESM-2 calibrated P(essential)=0.119; HANSEN integrated essentiality score=0.264; ProteomeLM contextual percentile=0.800; target-priority score=70.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 139 ML1130 P45837 thrC ML1130 Threonine synthase (TS) (EC 4.2.3.1) 360 0.13353 non-essential 0.26297 non-essential high NA medium_confidence NP_215811.1 93.9 0.69505 81.326 High-priority ESM-2 calibrated P(essential)=0.134; HANSEN integrated essentiality score=0.263; ProteomeLM contextual percentile=0.695; target-priority score=81.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 140 ML1014 Q59531 ML1014 RNA polymerase sigma factor 319 0.10418 non-essential 0.26279 non-essential high NA medium_confidence NP_217226.1 96.2 0.85348 72.883 Strong candidate ESM-2 calibrated P(essential)=0.104; HANSEN integrated essentiality score=0.263; ProteomeLM contextual percentile=0.853; target-priority score=72.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 141 ML2076 Q7APZ3 ML2076 FHA domain-containing protein 162 0.1873 non-essential 0.26272 non-essential high NA medium_confidence NP_216343.1 87.6 0.51346 58.674 Moderate candidate ESM-2 calibrated P(essential)=0.187; HANSEN integrated essentiality score=0.263; ProteomeLM contextual percentile=0.513; target-priority score=58.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 142 ML1719 Q9CBR1 ML1719 Transferase 245 0.13353 non-essential 0.26244 non-essential high NA medium_confidence NP_217550.1 90.6 0.72699 69.405 Strong candidate ESM-2 calibrated P(essential)=0.134; HANSEN integrated essentiality score=0.262; ProteomeLM contextual percentile=0.727; target-priority score=69.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 143 ML0914 O69552 murG ML0914 MLCB268.02c UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase (EC 2.4.1.227) (Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase) 407 0.18914 non-essential 0.26188 non-essential high NA medium_confidence NP_216669.1 76.6 0.44771 76.475 Strong candidate ESM-2 calibrated P(essential)=0.189; HANSEN integrated essentiality score=0.262; ProteomeLM contextual percentile=0.448; target-priority score=76.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 144 ML1357 Q9CC31 ML1357 Uncharacterized protein 61 0.12534 non-essential 0.26179 non-essential high NA medium_confidence Rv1693 73.8 UNCERTAIN 0.76832 66.829 Strong candidate ESM-2 calibrated P(essential)=0.125; HANSEN integrated essentiality score=0.262; ProteomeLM contextual percentile=0.768; target-priority score=66.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 145 ML1703 O33104 gatC ML1703 MLCB637.12 Glutamyl-tRNA(Gln) amidotransferase subunit C (Glu-ADT subunit C) (EC 6.3.5.-) 99 0.12863 non-essential 0.26173 non-essential high NA medium_confidence NP_217528.1 75.8 0.72824 75.195 Strong candidate ESM-2 calibrated P(essential)=0.129; HANSEN integrated essentiality score=0.262; ProteomeLM contextual percentile=0.728; target-priority score=75.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 146 ML0513 Q9CCS9 ML0513 Putative pre-16S rRNA nuclease (EC 3.1.-.-) 184 0.11111 non-essential 0.261 non-essential high NA medium_confidence NP_217070.1 71.3 0.80463 75.088 Strong candidate ESM-2 calibrated P(essential)=0.111; HANSEN integrated essentiality score=0.261; ProteomeLM contextual percentile=0.805; target-priority score=75.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 147 ML0141 Q9CD77 ML0141 Uncharacterized protein 84 0.08711 non-essential 0.26039 non-essential high NA medium_confidence 0.93049 68.517 Strong candidate ESM-2 calibrated P(essential)=0.087; HANSEN integrated essentiality score=0.260; ProteomeLM contextual percentile=0.930; target-priority score=68.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 148 ML0008 Q9CDF1 ML0008 Uncharacterized protein 124 0.07197 non-essential 0.26029 non-essential high NA medium_confidence 0.99061 71.509 Strong candidate ESM-2 calibrated P(essential)=0.072; HANSEN integrated essentiality score=0.260; ProteomeLM contextual percentile=0.991; target-priority score=71.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 149 ML0414 Q49734 otsB ML0414 MLCL383.17c Trehalose-phosphate phosphatase (TPP) (EC 3.1.3.12) (Trehalose-6-phosphate phosphatase) 429 0.14132 non-essential 0.2599 non-essential high NA medium_confidence NP_217889.1 67.1 0.64746 79.196 Strong candidate ESM-2 calibrated P(essential)=0.141; HANSEN integrated essentiality score=0.260; ProteomeLM contextual percentile=0.647; target-priority score=79.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 150 ML1974 Q9CBH5 ML1974 Transporter 572 0.09604 non-essential 0.25904 non-essential high NA medium_confidence NP_216495.2 77.1 0.8685 72.967 Strong candidate ESM-2 calibrated P(essential)=0.096; HANSEN integrated essentiality score=0.259; ProteomeLM contextual percentile=0.869; target-priority score=73.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 151 ML2288 Q9CBA0 ML2288 Uncharacterized protein 74 0.07033 non-essential 0.259 non-essential high NA medium_confidence 0.98748 72.539 Strong candidate ESM-2 calibrated P(essential)=0.070; HANSEN integrated essentiality score=0.259; ProteomeLM contextual percentile=0.987; target-priority score=72.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 152 ML0988 P37859 recX ML0988 u2235b Regulatory protein RecX 171 0.13407 non-essential 0.25878 non-essential high NA medium_confidence NP_217252.1 77.0 0.70507 68.696 Strong candidate ESM-2 calibrated P(essential)=0.134; HANSEN integrated essentiality score=0.259; ProteomeLM contextual percentile=0.705; target-priority score=68.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 153 ML2283 Q9CBA2 ML2283 Uncharacterized protein 104 0.09677 non-essential 0.25869 non-essential high NA medium_confidence 0.8779 67.93 Strong candidate ESM-2 calibrated P(essential)=0.097; HANSEN integrated essentiality score=0.259; ProteomeLM contextual percentile=0.878; target-priority score=67.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 154 ML0864 O32956 pepA ML0864 MLCB22.14 Probable cytosol aminopeptidase (EC 3.4.11.1) (Leucine aminopeptidase) (LAP) (EC 3.4.11.10) (Leucyl aminopeptidase) 524 0.19029 non-essential 0.2574 non-essential high NA medium_confidence NP_216729.1 83.0 0.43707 69.345 Strong candidate ESM-2 calibrated P(essential)=0.190; HANSEN integrated essentiality score=0.257; ProteomeLM contextual percentile=0.437; target-priority score=69.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 155 ML1495 Q9CBX4 mshB ML1495 1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside deacetylase (GlcNAc-Ins deacetylase) (EC 3.5.1.103) (N-acetyl-1-D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside deacetylase) 308 0.19217 non-essential 0.25736 non-essential high NA medium_confidence NP_215686.1 73.7 0.42956 68.889 Strong candidate ESM-2 calibrated P(essential)=0.192; HANSEN integrated essentiality score=0.257; ProteomeLM contextual percentile=0.430; target-priority score=68.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 156 ML0779 P57996 secA1 ML0779 Protein translocase subunit SecA 1 (EC 7.4.2.8) 940 0.23815 non-essential 0.25648 non-essential medium NA medium_confidence YP_177950.1 86.9 0.23982 59.91 Moderate candidate ESM-2 calibrated P(essential)=0.238; HANSEN integrated essentiality score=0.256; ProteomeLM contextual percentile=0.240; target-priority score=59.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:45Z 157 ML2387 Q50068 lpd ML2387 u1740l Dihydrolipoyl dehydrogenase (EC 1.8.1.4) (Dihydrolipoamide dehydrogenase) (E3 component of alpha-ketoacid dehydrogenase complexes) 467 0.23815 non-essential 0.25613 non-essential medium NA medium_confidence NP_214976.1 83.3 0.22855 63.042 Moderate candidate ESM-2 calibrated P(essential)=0.238; HANSEN integrated essentiality score=0.256; ProteomeLM contextual percentile=0.229; target-priority score=63.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 158 ML2114 Q9CBE3 ML2114 Antitoxin 56 0.06758 non-essential 0.25598 non-essential high NA medium_confidence NP_215424.1 61.9 0.97934 73.577 Strong candidate ESM-2 calibrated P(essential)=0.068; HANSEN integrated essentiality score=0.256; ProteomeLM contextual percentile=0.979; target-priority score=73.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 159 ML0364 P38014 rplM ML0364 B229_C3_232 Large ribosomal subunit protein uL13 (50S ribosomal protein L13) 147 0.23313 non-essential 0.25574 non-essential medium NA medium_confidence NP_217960.1 91.8 0.27176 55.393 Moderate candidate ESM-2 calibrated P(essential)=0.233; HANSEN integrated essentiality score=0.256; ProteomeLM contextual percentile=0.272; target-priority score=55.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 160 ML1890 P30761 rpoC ML1890 DNA-directed RNA polymerase subunit beta' (RNAP subunit beta') (EC 2.7.7.6) (RNA polymerase subunit beta') (Transcriptase subunit beta') 1316 0.26646 non-essential 0.25545 non-essential medium NA medium_confidence NP_215182.1 94.6 0.11334 56.695 Moderate candidate ESM-2 calibrated P(essential)=0.266; HANSEN integrated essentiality score=0.255; ProteomeLM contextual percentile=0.113; target-priority score=56.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:45Z 161 ML0926 Q9CCD7 ML0926 Uncharacterized protein 122 0.08711 non-essential 0.25486 non-essential high NA medium_confidence 0.88729 72.158 Strong candidate ESM-2 calibrated P(essential)=0.087; HANSEN integrated essentiality score=0.255; ProteomeLM contextual percentile=0.887; target-priority score=72.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 162 ML1928 Q9CBI3 ML1928 Uncharacterized protein 45 0.06279 non-essential 0.25457 non-essential high NA medium_confidence 0.98936 74.8 Strong candidate ESM-2 calibrated P(essential)=0.063; HANSEN integrated essentiality score=0.255; ProteomeLM contextual percentile=0.989; target-priority score=74.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 163 ML0633 Q9CCN0 recO ML0633 B1937_F1_25 DNA repair protein RecO (Recombination protein O) 268 0.11487 non-essential 0.25446 non-essential high NA medium_confidence NP_216878.1 86.6 0.76268 70.414 Strong candidate ESM-2 calibrated P(essential)=0.115; HANSEN integrated essentiality score=0.254; ProteomeLM contextual percentile=0.763; target-priority score=70.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 164 ML0939 Q9CCD3 ML0939 Uncharacterized protein 80 0.06236 non-essential 0.25421 non-essential high NA medium_confidence 1.0 71.14 Strong candidate ESM-2 calibrated P(essential)=0.062; HANSEN integrated essentiality score=0.254; ProteomeLM contextual percentile=1.000; target-priority score=71.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 165 ML1911 Q9CBJ5 rpmG ML1911 Large ribosomal subunit protein bL33 (50S ribosomal protein L33) 55 0.14132 non-essential 0.25413 non-essential high NA medium_confidence YP_177630.1 92.7 0.64621 68.092 Strong candidate ESM-2 calibrated P(essential)=0.141; HANSEN integrated essentiality score=0.254; ProteomeLM contextual percentile=0.646; target-priority score=68.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 166 ML2467 Q9CB36 ML2467 Short-chain Z-isoprenyl diphosphate synthase (EC 2.5.1.68) ((2Z,6E)-farnesyl diphosphate synthase) (Z-FPP synthase) (Z-isoprenyl diphosphate synthase) 262 0.18914 non-essential 0.2531 non-essential high NA medium_confidence NP_215602.1 90.8 0.40451 73.607 Strong candidate ESM-2 calibrated P(essential)=0.189; HANSEN integrated essentiality score=0.253; ProteomeLM contextual percentile=0.405; target-priority score=73.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 167 ML0210 O69540 ppa ML0210 MLCB2548.21 Inorganic pyrophosphatase (EC 3.6.1.1) (Pyrophosphate phospho-hydrolase) (PPase) 162 0.14132 non-essential 0.25309 non-essential high NA medium_confidence NP_218145.1 90.1 0.61803 75.595 Strong candidate ESM-2 calibrated P(essential)=0.141; HANSEN integrated essentiality score=0.253; ProteomeLM contextual percentile=0.618; target-priority score=75.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 168 ML2565 Q7APU2 fabG4 ML2565 Possible oxidoreductase 454 0.23512 non-essential 0.25256 non-essential medium NA medium_confidence NP_214756.1 85.0 0.24421 55.306 Moderate candidate ESM-2 calibrated P(essential)=0.235; HANSEN integrated essentiality score=0.253; ProteomeLM contextual percentile=0.244; target-priority score=55.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 169 ML0540 Q9CCQ8 mihF ML0540 Integration host factor 105 0.13339 non-essential 0.25251 non-essential high NA medium_confidence NP_215904.1 97.1 0.67689 66.79 Strong candidate ESM-2 calibrated P(essential)=0.133; HANSEN integrated essentiality score=0.253; ProteomeLM contextual percentile=0.677; target-priority score=66.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 170 ML0775 Q9CCJ0 lpqB ML0775 Lipoprotein LpqB 589 0.13829 non-essential 0.25179 non-essential high NA medium_confidence NP_217761.1 87.9 0.65059 66.648 Strong candidate ESM-2 calibrated P(essential)=0.138; HANSEN integrated essentiality score=0.252; ProteomeLM contextual percentile=0.651; target-priority score=66.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 171 ML0928 Q9CCD5 ML0928 Uncharacterized protein 94 0.05949 non-essential 0.25128 non-essential high NA medium_confidence 0.99562 71.249 Strong candidate ESM-2 calibrated P(essential)=0.059; HANSEN integrated essentiality score=0.251; ProteomeLM contextual percentile=0.996; target-priority score=71.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 172 ML1292 Q7AQ76 ML1292 Uncharacterized protein 80 0.06963 non-essential 0.25114 non-essential high NA medium_confidence 0.95116 70.267 Strong candidate ESM-2 calibrated P(essential)=0.070; HANSEN integrated essentiality score=0.251; ProteomeLM contextual percentile=0.951; target-priority score=70.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 173 ML0317 P09239 groEL2 groL2 ML0317 MLCB1450.05c Chaperonin GroEL 2 (EC 5.6.1.7) (60 kDa chaperonin 2) (65 kDa antigen) (Chaperonin-60 2) (Cpn60 2) 541 0.1873 non-essential 0.2511 non-essential high NA medium_confidence NP_214954.1 94.8 0.41641 68.438 Strong candidate ESM-2 calibrated P(essential)=0.187; HANSEN integrated essentiality score=0.251; ProteomeLM contextual percentile=0.416; target-priority score=68.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 174 ML0573 Q7AQI5 ML0573 Uncharacterized protein 91 0.07832 non-essential 0.2511 non-essential high NA medium_confidence 0.91108 70.252 Strong candidate ESM-2 calibrated P(essential)=0.078; HANSEN integrated essentiality score=0.251; ProteomeLM contextual percentile=0.911; target-priority score=70.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 175 ML0208 Q7AQL7 ML0208 Membrane protein 113 0.15001 non-essential 0.25097 non-essential high NA medium_confidence NP_218149.1 82.0 0.61115 60.142 Moderate candidate ESM-2 calibrated P(essential)=0.150; HANSEN integrated essentiality score=0.251; ProteomeLM contextual percentile=0.611; target-priority score=60.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 176 ML1717 Q9CBR2 ML1717 Doubtful CDS 97 0.06981 non-essential 0.25054 non-essential high NA medium_confidence 0.95053 69.001 Strong candidate ESM-2 calibrated P(essential)=0.070; HANSEN integrated essentiality score=0.251; ProteomeLM contextual percentile=0.951; target-priority score=69.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 177 ML1796 P13733 ML1796 Uncharacterized protein ML1796 137 0.06601 non-essential 0.24994 non-essential high NA medium_confidence 0.95554 72.017 Strong candidate ESM-2 calibrated P(essential)=0.066; HANSEN integrated essentiality score=0.250; ProteomeLM contextual percentile=0.956; target-priority score=72.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 178 ML1057 Q7AQA0 ML1057 Uncharacterized protein 117 0.07218 non-essential 0.2497 non-essential high NA medium_confidence 0.93613 68.505 Strong candidate ESM-2 calibrated P(essential)=0.072; HANSEN integrated essentiality score=0.250; ProteomeLM contextual percentile=0.936; target-priority score=68.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 179 ML0424 Q7AQJ4 bcp ML0424 thioredoxin-dependent peroxiredoxin (EC 1.11.1.24) (Bacterioferritin comigratory protein) (Thioredoxin peroxidase) 161 0.09638 non-essential 0.24965 non-essential high NA medium_confidence NP_217037.1 80.3 0.7871 81.33 High-priority ESM-2 calibrated P(essential)=0.096; HANSEN integrated essentiality score=0.250; ProteomeLM contextual percentile=0.787; target-priority score=81.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 180 ML2201 Q9CBC5 ML2201 Uncharacterized protein 79 0.06543 non-essential 0.24922 non-essential high NA medium_confidence 0.9593 70.193 Strong candidate ESM-2 calibrated P(essential)=0.065; HANSEN integrated essentiality score=0.249; ProteomeLM contextual percentile=0.959; target-priority score=70.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 181 ML0957 Q9CCC7 ML0957 Uncharacterized protein 124 0.07625 non-essential 0.2487 non-essential high NA medium_confidence 0.90983 69.12 Strong candidate ESM-2 calibrated P(essential)=0.076; HANSEN integrated essentiality score=0.249; ProteomeLM contextual percentile=0.910; target-priority score=69.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 182 ML2161 Q9CBD8 fadB ML2161 Fatty oxidation complex alpha subunit 714 0.14132 non-essential 0.24834 non-essential high NA medium_confidence NP_215375.1 88.6 0.59424 74.173 Strong candidate ESM-2 calibrated P(essential)=0.141; HANSEN integrated essentiality score=0.248; ProteomeLM contextual percentile=0.594; target-priority score=74.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 183 ML0042 Q7AQP3 ML0042 Membrane protein 467 0.13353 non-essential 0.24825 non-essential high NA medium_confidence NP_218399.1 72.1 0.65122 66.783 Strong candidate ESM-2 calibrated P(essential)=0.134; HANSEN integrated essentiality score=0.248; ProteomeLM contextual percentile=0.651; target-priority score=66.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 184 ML1904 Q9CBK2 rplA ML1904 Large ribosomal subunit protein uL1 (50S ribosomal protein L1) 235 0.1873 non-essential 0.24758 non-essential high NA medium_confidence NP_215155.1 93.6 0.41703 61.193 Moderate candidate ESM-2 calibrated P(essential)=0.187; HANSEN integrated essentiality score=0.248; ProteomeLM contextual percentile=0.417; target-priority score=61.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 185 ML1133 P45834 rpmE ML1133 Large ribosomal subunit protein bL31 (50S ribosomal protein L31) 84 0.08115 non-essential 0.24756 non-essential high NA medium_confidence NP_215814.1 89.6 0.86036 76.006 Strong candidate ESM-2 calibrated P(essential)=0.081; HANSEN integrated essentiality score=0.248; ProteomeLM contextual percentile=0.860; target-priority score=76.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 186 ML1840 O33002 rplO ML1840 MLCB2492.23 Large ribosomal subunit protein uL15 (50S ribosomal protein L15) 146 0.15591 non-essential 0.24755 non-essential high NA medium_confidence NP_215237.1 82.2 0.55291 63.888 Moderate candidate ESM-2 calibrated P(essential)=0.156; HANSEN integrated essentiality score=0.248; ProteomeLM contextual percentile=0.553; target-priority score=63.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 187 ML2323 Q9CB77 ask ML2323 Aspartokinase (EC 2.7.2.4) 421 0.27523 non-essential 0.24751 non-essential medium NA medium_confidence NP_218226.1 92.9 0.02379 57.572 Moderate candidate ESM-2 calibrated P(essential)=0.275; HANSEN integrated essentiality score=0.248; ProteomeLM contextual percentile=0.024; target-priority score=57.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 188 ML1922 Q9CBI8 ML1922 ABM domain-containing protein 105 0.12209 non-essential 0.24712 non-essential high NA medium_confidence NP_218109.1 84.6 0.70194 65.121 Strong candidate ESM-2 calibrated P(essential)=0.122; HANSEN integrated essentiality score=0.247; ProteomeLM contextual percentile=0.702; target-priority score=65.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 189 ML1863 P30762 rplC ML1863 MLCB2492.02 Large ribosomal subunit protein uL3 (50S ribosomal protein L3) 217 0.24684 non-essential 0.24688 non-essential medium NA medium_confidence NP_215215.1 93.1 0.16969 50.99 Moderate candidate ESM-2 calibrated P(essential)=0.247; HANSEN integrated essentiality score=0.247; ProteomeLM contextual percentile=0.170; target-priority score=51.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 190 ML1864 P30765 rpsJ ML1864 Small ribosomal subunit protein uS10 (30S ribosomal protein S10) 101 0.20179 non-essential 0.24682 non-essential medium NA medium_confidence NP_215214.1 98.0 0.35567 57.92 Moderate candidate ESM-2 calibrated P(essential)=0.202; HANSEN integrated essentiality score=0.247; ProteomeLM contextual percentile=0.356; target-priority score=57.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 191 ML1601 Q7AQ39 ML1601 Carbamoyltransferase domain-containing protein 121 0.04985 non-essential 0.24658 non-essential high NA medium_confidence 0.99374 77.526 Strong candidate ESM-2 calibrated P(essential)=0.050; HANSEN integrated essentiality score=0.247; ProteomeLM contextual percentile=0.994; target-priority score=77.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 192 ML2439 P54884 rgx3 ML2439 B2168_C3_248 Sensory transduction protein RegX3 198 0.12863 non-essential 0.24623 non-essential high NA medium_confidence NP_215005.1 95.4 0.66437 65.92 Strong candidate ESM-2 calibrated P(essential)=0.129; HANSEN integrated essentiality score=0.246; ProteomeLM contextual percentile=0.664; target-priority score=65.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 193 ML0524 Q9CCR8 adi ML0524 Amino acid decarboxylase 950 0.17728 non-essential 0.24587 non-essential high NA medium_confidence YP_177889.1 86.4 0.4546 60.609 Moderate candidate ESM-2 calibrated P(essential)=0.177; HANSEN integrated essentiality score=0.246; ProteomeLM contextual percentile=0.455; target-priority score=60.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:45Z 194 ML1106 Q9CC90 ML1106 Uncharacterized protein 113 0.05502 non-essential 0.24572 non-essential high NA medium_confidence 0.97057 75.61 Strong candidate ESM-2 calibrated P(essential)=0.055; HANSEN integrated essentiality score=0.246; ProteomeLM contextual percentile=0.971; target-priority score=75.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 195 ML2635 Q9CCZ7 pntAB ML2635 proton-translocating NAD(P)(+) transhydrogenase (EC 7.1.1.1) 112 0.10418 non-essential 0.24516 non-essential high NA medium_confidence NP_214670.1 82.9 0.74515 74.448 Strong candidate ESM-2 calibrated P(essential)=0.104; HANSEN integrated essentiality score=0.245; ProteomeLM contextual percentile=0.745; target-priority score=74.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 196 ML1712 O33095 etfB fixA ML1712 MLCB637.03 Electron transfer flavoprotein subunit beta (Beta-ETF) (Electron transfer flavoprotein small subunit) (ETFSS) 266 0.19217 non-essential 0.24445 non-essential high NA medium_confidence NP_217545.1 95.1 0.38447 58.401 Moderate candidate ESM-2 calibrated P(essential)=0.192; HANSEN integrated essentiality score=0.244; ProteomeLM contextual percentile=0.384; target-priority score=58.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 197 ML0105 Q9CDA8 embA ML0105 Probable arabinosyltransferase A (EC 2.4.2.-) 1111 0.09071 non-essential 0.24444 non-essential high NA medium_confidence NP_218311.1 78.6 0.79524 76.996 Strong candidate ESM-2 calibrated P(essential)=0.091; HANSEN integrated essentiality score=0.244; ProteomeLM contextual percentile=0.795; target-priority score=77.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:45Z 198 ML0565 Q9CCN8 whiA ML0565 Probable cell division protein WhiA 327 0.28398 non-essential 0.24411 non-essential medium NA medium_confidence NP_215939.1 92.0 0.00125 44.772 Exploratory ESM-2 calibrated P(essential)=0.284; HANSEN integrated essentiality score=0.244; ProteomeLM contextual percentile=0.001; target-priority score=44.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 199 ML0102 Q9CDB0 accD4 ML0102 Acyl CoA carboxylase [beta] subunit 517 0.1299 non-essential 0.24384 non-essential high NA medium_confidence NP_218316.2 91.1 0.64183 66.817 Strong candidate ESM-2 calibrated P(essential)=0.130; HANSEN integrated essentiality score=0.244; ProteomeLM contextual percentile=0.642; target-priority score=66.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 200 ML0913 Q7AQC4 ftsW ML0913 Probable peptidoglycan glycosyltransferase FtsW (EC 2.4.99.28) (Cell division protein FtsW) (Cell wall polymerase) (Peptidoglycan polymerase) 534 0.09677 non-essential 0.2436 non-essential high NA medium_confidence NP_216670.1 78.1 0.74452 83.098 High-priority ESM-2 calibrated P(essential)=0.097; HANSEN integrated essentiality score=0.244; ProteomeLM contextual percentile=0.745; target-priority score=83.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 201 ML1445 Q9CC03 ML1445 Uncharacterized protein 74 0.06257 non-essential 0.2432 non-essential high NA medium_confidence 0.93863 69.662 Strong candidate ESM-2 calibrated P(essential)=0.063; HANSEN integrated essentiality score=0.243; ProteomeLM contextual percentile=0.939; target-priority score=69.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 202 ML2044 Q9CBF4 ML2044 Uncharacterized protein 73 0.05242 non-essential 0.2432 non-essential high NA medium_confidence 0.98059 71.218 Strong candidate ESM-2 calibrated P(essential)=0.052; HANSEN integrated essentiality score=0.243; ProteomeLM contextual percentile=0.981; target-priority score=71.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 203 ML0916 Q9CCE5 ftsQ ML0916 Cell division protein FtsQ 341 0.06716 non-essential 0.24297 non-essential high NA medium_confidence NP_216667.1 70.0 0.89668 76.295 Strong candidate ESM-2 calibrated P(essential)=0.067; HANSEN integrated essentiality score=0.243; ProteomeLM contextual percentile=0.897; target-priority score=76.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 204 ML0592 Q7AQH6 ML0592 DNA-binding protein 254 0.10418 non-essential 0.24294 non-essential high NA medium_confidence NP_215976.2 81.3 0.74953 68.529 Strong candidate ESM-2 calibrated P(essential)=0.104; HANSEN integrated essentiality score=0.243; ProteomeLM contextual percentile=0.750; target-priority score=68.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 205 ML1555 Q9Z5I8 rbfA ML1555 MLCB596.15 Ribosome-binding factor A 164 0.23801 non-essential 0.24259 non-essential medium NA medium_confidence NP_217354.1 80.8 0.18597 50.665 Moderate candidate ESM-2 calibrated P(essential)=0.238; HANSEN integrated essentiality score=0.243; ProteomeLM contextual percentile=0.186; target-priority score=50.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 206 ML0853 O32967 rpsO ML0853 MLCB22.28c Small ribosomal subunit protein uS15 (30S ribosomal protein S15) 89 0.09599 non-essential 0.24223 non-essential high NA medium_confidence NP_217301.1 93.3 0.76957 73.078 Strong candidate ESM-2 calibrated P(essential)=0.096; HANSEN integrated essentiality score=0.242; ProteomeLM contextual percentile=0.770; target-priority score=73.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 207 ML2347 Q7APW0 ML2347 Membrane protein 336 0.07497 non-essential 0.24223 non-essential high NA medium_confidence 0.86976 71.781 Strong candidate ESM-2 calibrated P(essential)=0.075; HANSEN integrated essentiality score=0.242; ProteomeLM contextual percentile=0.870; target-priority score=71.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 208 ML2045 Q9CBF3 ML2045 Uncharacterized protein 85 0.06371 non-essential 0.24175 non-essential high NA medium_confidence 0.91609 72.65 Strong candidate ESM-2 calibrated P(essential)=0.064; HANSEN integrated essentiality score=0.242; ProteomeLM contextual percentile=0.916; target-priority score=72.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 209 ML2433 P54580 ML2433 B2168_C2_209 Uncharacterized protein ML2433 355 0.08883 non-essential 0.24165 non-essential high NA medium_confidence NP_215011.1 51.7 0.81653 67.095 Strong candidate ESM-2 calibrated P(essential)=0.089; HANSEN integrated essentiality score=0.242; ProteomeLM contextual percentile=0.817; target-priority score=67.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 210 ML2569 Q7APU0 ML2569 beta-N-acetylhexosaminidase (EC 3.2.1.52) 387 0.06482 non-essential 0.24164 non-essential high NA medium_confidence YP_177702.1 72.8 0.88103 82.608 High-priority ESM-2 calibrated P(essential)=0.065; HANSEN integrated essentiality score=0.242; ProteomeLM contextual percentile=0.881; target-priority score=82.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 211 ML1272 Q9CC54 trpB ML1272 Tryptophan synthase beta chain (EC 4.2.1.20) 417 0.09441 non-essential 0.24106 non-essential high NA medium_confidence NP_216128.1 86.7 0.7464 81.069 High-priority ESM-2 calibrated P(essential)=0.094; HANSEN integrated essentiality score=0.241; ProteomeLM contextual percentile=0.746; target-priority score=81.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 212 ML2683 O53125 rpsR ML2683 MLCB1913.19c Small ribosomal subunit protein bS18 (30S ribosomal protein S18) 84 0.15264 non-essential 0.24095 non-essential high NA medium_confidence YP_177688.1 90.5 0.52974 63.672 Moderate candidate ESM-2 calibrated P(essential)=0.153; HANSEN integrated essentiality score=0.241; ProteomeLM contextual percentile=0.530; target-priority score=63.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 213 ML2570 Q9CD19 ML2570 Alpha-(1->3)-arabinofuranosyltransferase (EC 2.4.2.47) (Arabinofuranan 3-O-arabinosyltransferase) 1405 0.10115 non-essential 0.24031 non-essential high NA medium_confidence NP_214750.1 78.7 0.71697 79.064 Strong candidate ESM-2 calibrated P(essential)=0.101; HANSEN integrated essentiality score=0.240; ProteomeLM contextual percentile=0.717; target-priority score=79.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:45Z 214 ML1294 Q9CC44 ML1294 Dihydroorotate dehydrogenase 84 0.09625 non-essential 0.2395 non-essential high NA medium_confidence 0.76518 68.688 Strong candidate ESM-2 calibrated P(essential)=0.096; HANSEN integrated essentiality score=0.239; ProteomeLM contextual percentile=0.765; target-priority score=68.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 215 ML1508 Q9CBW7 ML1508 Pyridoxamine 5'-phosphate oxidase N-terminal domain-containing protein 163 0.09148 non-essential 0.23893 non-essential high NA medium_confidence NP_215671.1 87.8 0.7727 72.422 Strong candidate ESM-2 calibrated P(essential)=0.091; HANSEN integrated essentiality score=0.239; ProteomeLM contextual percentile=0.773; target-priority score=72.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 216 ML0596 Q49690 csd2 ML0596 B1496_C2_193 MLCL536.25c Probable cysteine desulfurase 2 (EC 2.8.1.7) 418 0.23313 non-essential 0.23858 non-essential medium NA medium_confidence NP_215980.1 85.4 0.15842 59.612 Moderate candidate ESM-2 calibrated P(essential)=0.233; HANSEN integrated essentiality score=0.239; ProteomeLM contextual percentile=0.158; target-priority score=59.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 217 ML1832 O33007 adk ML1832 MLCB2492.28 Adenylate kinase (AK) (EC 2.7.4.3) (ATP-AMP transphosphorylase) (ATP:AMP phosphotransferase) (Adenylate monophosphate kinase) 181 0.174 non-essential 0.23839 non-essential high NA medium_confidence NP_215247.1 84.0 0.39637 70.572 Strong candidate ESM-2 calibrated P(essential)=0.174; HANSEN integrated essentiality score=0.238; ProteomeLM contextual percentile=0.396; target-priority score=70.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 218 ML0223 O69531 folE ML0223 MLCB2548.08c GTP cyclohydrolase 1 (EC 3.5.4.16) (GTP cyclohydrolase I) (GTP-CH-I) 205 0.09638 non-essential 0.23839 non-essential high NA medium_confidence NP_218126.1 84.6 0.71446 83.5 High-priority ESM-2 calibrated P(essential)=0.096; HANSEN integrated essentiality score=0.238; ProteomeLM contextual percentile=0.714; target-priority score=83.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 219 ML1001 Q9CCB9 ML1001 Uncharacterized protein 91 0.04243 non-essential 0.23812 non-essential high NA medium_confidence 0.99687 71.101 Strong candidate ESM-2 calibrated P(essential)=0.042; HANSEN integrated essentiality score=0.238; ProteomeLM contextual percentile=0.997; target-priority score=71.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 220 ML1941 Q9X784 xseB ML1941 MLCB1222.09 Exodeoxyribonuclease 7 small subunit (EC 3.1.11.6) (Exodeoxyribonuclease VII small subunit) (Exonuclease VII small subunit) 78 0.06636 non-essential 0.23807 non-essential high NA medium_confidence NP_215623.1 84.1 0.86349 79.03 Strong candidate ESM-2 calibrated P(essential)=0.066; HANSEN integrated essentiality score=0.238; ProteomeLM contextual percentile=0.863; target-priority score=79.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 221 ML0685 Q7AQG1 ML0685 Hydrolase 303 0.08446 non-essential 0.23804 non-essential high NA medium_confidence 0.79837 72.877 Strong candidate ESM-2 calibrated P(essential)=0.084; HANSEN integrated essentiality score=0.238; ProteomeLM contextual percentile=0.798; target-priority score=72.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 222 ML0299 Q7AQJ9 ML0299 glycine oxidase (EC 1.4.3.19) 340 0.11185 non-essential 0.23759 non-essential high NA medium_confidence NP_214929.1 83.1 0.65373 78.429 Strong candidate ESM-2 calibrated P(essential)=0.112; HANSEN integrated essentiality score=0.238; ProteomeLM contextual percentile=0.654; target-priority score=78.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 223 ML0132 Q9CD84 fadD29 ML0132 Acyl-CoA synthetase 680 0.06543 non-essential 0.23732 non-essential high NA medium_confidence NP_217466.3 80.2 0.87226 75.993 Strong candidate ESM-2 calibrated P(essential)=0.065; HANSEN integrated essentiality score=0.237; ProteomeLM contextual percentile=0.872; target-priority score=76.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 224 ML1818 Q9CBL1 trxB ML1818 Thioredoxin 130 0.05422 non-essential 0.23714 non-essential high NA medium_confidence YP_177815.1 65.4 0.92173 76.298 Strong candidate ESM-2 calibrated P(essential)=0.054; HANSEN integrated essentiality score=0.237; ProteomeLM contextual percentile=0.922; target-priority score=76.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 225 ML0878 Q9CCE8 ML0878 Transmembrane protein 212 0.09201 non-essential 0.23701 non-essential high NA medium_confidence NP_216713.1 62.6 0.77896 65.646 Strong candidate ESM-2 calibrated P(essential)=0.092; HANSEN integrated essentiality score=0.237; ProteomeLM contextual percentile=0.779; target-priority score=65.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 226 ML1394 Q9CC22 infC ML1394 Translation initiation factor IF-3 202 0.13353 non-essential 0.23681 non-essential high NA medium_confidence NP_216157.1 90.1 0.58986 64.768 Moderate candidate ESM-2 calibrated P(essential)=0.134; HANSEN integrated essentiality score=0.237; ProteomeLM contextual percentile=0.590; target-priority score=64.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 227 ML1225 Q49622 nadA ML1225 B1170_C2_201 Quinolinate synthase (EC 2.5.1.72) 352 0.14132 non-essential 0.23652 non-essential high NA medium_confidence NP_216110.1 84.7 0.51722 76.736 Strong candidate ESM-2 calibrated P(essential)=0.141; HANSEN integrated essentiality score=0.237; ProteomeLM contextual percentile=0.517; target-priority score=76.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 228 ML2265 Q9CBB3 ML2265 Uncharacterized protein 73 0.04027 non-essential 0.23598 non-essential high NA medium_confidence 0.98873 72.97 Strong candidate ESM-2 calibrated P(essential)=0.040; HANSEN integrated essentiality score=0.236; ProteomeLM contextual percentile=0.989; target-priority score=73.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 229 ML1089 Q7AQ92 ML1089 Trehalose import ATP-binding protein SugC (Nucleotide-binding domain of SugABC transporter) (SugABC transporter ATPase SugC) 392 0.19217 non-essential 0.23579 non-essential high NA medium_confidence NP_215754.1 79.9 0.335 57.89 Moderate candidate ESM-2 calibrated P(essential)=0.192; HANSEN integrated essentiality score=0.236; ProteomeLM contextual percentile=0.335; target-priority score=57.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 230 ML0482 P40832 ruvA ML0482 B1177_C2_188 Holliday junction branch migration complex subunit RuvA 203 0.09148 non-essential 0.23579 non-essential high NA medium_confidence NP_217109.1 76.8 0.75517 72.106 Strong candidate ESM-2 calibrated P(essential)=0.091; HANSEN integrated essentiality score=0.236; ProteomeLM contextual percentile=0.755; target-priority score=72.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 231 ML0588 Q7AQI0 ML0588 PPE-PPW subfamily C-terminal domain-containing protein 80 0.04552 non-essential 0.23577 non-essential high NA medium_confidence 0.9712 70.322 Strong candidate ESM-2 calibrated P(essential)=0.046; HANSEN integrated essentiality score=0.236; ProteomeLM contextual percentile=0.971; target-priority score=70.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 232 ML0007 O32870 ML0007 MLB1770.07 Uncharacterized protein ML0007 303 0.07317 non-essential 0.23574 non-essential high NA medium_confidence NP_214521.1 53.8 0.84972 68.434 Strong candidate ESM-2 calibrated P(essential)=0.073; HANSEN integrated essentiality score=0.236; ProteomeLM contextual percentile=0.850; target-priority score=68.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 233 ML0580 Q7AQI2 ML0580 Glucose-6-phosphate dehydrogenase assembly protein OpcA 265 0.05322 non-essential 0.2357 non-essential high NA medium_confidence NP_215962.1 70.3 0.92486 73.938 Strong candidate ESM-2 calibrated P(essential)=0.053; HANSEN integrated essentiality score=0.236; ProteomeLM contextual percentile=0.925; target-priority score=73.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 234 ML0178 Q9Z5G4 mscL ML0178 MLCB373.30c Large-conductance mechanosensitive channel 154 0.09832 non-essential 0.23563 non-essential high NA medium_confidence NP_215500.1 71.0 0.74014 66.23 Strong candidate ESM-2 calibrated P(essential)=0.098; HANSEN integrated essentiality score=0.236; ProteomeLM contextual percentile=0.740; target-priority score=66.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 235 ML0575 Q9CCN6 ML0575 Uncharacterized protein 72 0.04063 non-essential 0.23561 non-essential high NA medium_confidence 0.9856 72.72 Strong candidate ESM-2 calibrated P(essential)=0.041; HANSEN integrated essentiality score=0.236; ProteomeLM contextual percentile=0.986; target-priority score=72.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 236 ML2562 Q9CD23 ML2562 Uncharacterized protein 96 0.04985 non-essential 0.23555 non-essential high NA medium_confidence 0.95178 69.739 Strong candidate ESM-2 calibrated P(essential)=0.050; HANSEN integrated essentiality score=0.236; ProteomeLM contextual percentile=0.952; target-priority score=69.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 237 ML0376 Q9CCV4 ML0376 Membrane protein 333 0.05422 non-essential 0.23525 non-essential high NA medium_confidence 0.92298 72.1 Strong candidate ESM-2 calibrated P(essential)=0.054; HANSEN integrated essentiality score=0.235; ProteomeLM contextual percentile=0.923; target-priority score=72.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 238 ML0177 Q7AQN0 moaB ML0177 Molybdenum cofactor biosynthesis protein 181 0.10418 non-essential 0.23512 non-essential high NA medium_confidence NP_215499.1 88.4 0.68942 73.322 Strong candidate ESM-2 calibrated P(essential)=0.104; HANSEN integrated essentiality score=0.235; ProteomeLM contextual percentile=0.689; target-priority score=73.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 239 ML0137 Q7AQN7 mmpL7 ML0137 Membrane protein 902 0.07497 non-essential 0.23465 non-essential high NA medium_confidence NP_217458.1 61.1 0.82467 71.951 Strong candidate ESM-2 calibrated P(essential)=0.075; HANSEN integrated essentiality score=0.235; ProteomeLM contextual percentile=0.825; target-priority score=72.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:45Z 240 ML0131 Q9CD85 ML0131 Phthiodiolone/phenolphthiodiolone dimycocerosates ketoreductase (EC 1.2.-.-) 382 0.13353 non-essential 0.23457 non-essential high NA medium_confidence NP_217467.1 85.1 0.56481 68.813 Strong candidate ESM-2 calibrated P(essential)=0.134; HANSEN integrated essentiality score=0.235; ProteomeLM contextual percentile=0.565; target-priority score=68.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 241 ML0595 Q7AQH5 ML0595 ABC transporter ATP-binding protein 260 0.25358 non-essential 0.23443 non-essential medium NA medium_confidence NP_215979.1 85.8 0.07827 46.656 Exploratory ESM-2 calibrated P(essential)=0.254; HANSEN integrated essentiality score=0.234; ProteomeLM contextual percentile=0.078; target-priority score=46.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 242 ML0185 Q7AQM6 ML0185 Membrane protein 342 0.15503 non-essential 0.23436 non-essential high NA medium_confidence NP_215511.1 63.3 0.50595 54.846 Moderate candidate ESM-2 calibrated P(essential)=0.155; HANSEN integrated essentiality score=0.234; ProteomeLM contextual percentile=0.506; target-priority score=54.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 243 ML0265 Q7AQK9 ML0265 Uncharacterized protein 70 0.0582 non-essential 0.23425 non-essential high NA medium_confidence 0.90482 70.07 Strong candidate ESM-2 calibrated P(essential)=0.058; HANSEN integrated essentiality score=0.234; ProteomeLM contextual percentile=0.905; target-priority score=70.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 244 ML1654 O69475 acpM ML1654 MLCB1243.21c Meromycolate extension acyl carrier protein (ACP) 115 0.09683 non-essential 0.23416 non-essential high NA medium_confidence NP_216760.1 96.8 0.73325 67.969 Strong candidate ESM-2 calibrated P(essential)=0.097; HANSEN integrated essentiality score=0.234; ProteomeLM contextual percentile=0.733; target-priority score=68.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 245 ML0293 Q9CCX1 ML0293 Uncharacterized protein 69 0.07033 non-essential 0.23414 non-essential high NA medium_confidence 0.85097 69.225 Strong candidate ESM-2 calibrated P(essential)=0.070; HANSEN integrated essentiality score=0.234; ProteomeLM contextual percentile=0.851; target-priority score=69.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 246 ML0381 P37578 groEL1 groE1 groL1 ML0381 B1620_C3_228 B229_C3_248 Chaperonin GroEL 1 (EC 5.6.1.7) (60 kDa chaperonin 1) (Chaperonin-60 1) (Cpn60 1) 537 0.14132 non-essential 0.23406 non-essential high NA medium_confidence NP_217934.1 82.9 0.5191 71.174 Strong candidate ESM-2 calibrated P(essential)=0.141; HANSEN integrated essentiality score=0.234; ProteomeLM contextual percentile=0.519; target-priority score=71.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 247 ML2273 Q9CBA8 menG ML2273 Demethylmenaquinone methyltransferase (EC 2.1.1.163) 230 0.09148 non-essential 0.23346 non-essential high NA medium_confidence YP_177738.1 83.8 0.71259 81.924 High-priority ESM-2 calibrated P(essential)=0.091; HANSEN integrated essentiality score=0.233; ProteomeLM contextual percentile=0.713; target-priority score=81.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 248 ML2252 Q7APX0 ML2252 Uncharacterized protein 78 0.04115 non-essential 0.23345 non-essential high NA medium_confidence 0.9737 71.635 Strong candidate ESM-2 calibrated P(essential)=0.041; HANSEN integrated essentiality score=0.233; ProteomeLM contextual percentile=0.974; target-priority score=71.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 249 ML1611 O33022 rnhB ML1611 MLCB250.40 Ribonuclease HII (RNase HII) (EC 3.1.26.4) 240 0.06124 non-essential 0.23344 non-essential high NA medium_confidence NP_217418.1 76.7 0.84534 83.926 High-priority ESM-2 calibrated P(essential)=0.061; HANSEN integrated essentiality score=0.233; ProteomeLM contextual percentile=0.845; target-priority score=83.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 250 ML2176 Q9CBD2 ML2176 Uncharacterized protein 85 0.06183 non-essential 0.23326 non-essential high NA medium_confidence 0.88666 68.602 Strong candidate ESM-2 calibrated P(essential)=0.062; HANSEN integrated essentiality score=0.233; ProteomeLM contextual percentile=0.887; target-priority score=68.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 251 ML2454 Q9CB42 hbhA ML2454 Heparin-binding hemagglutinin homolog (Adhesin) 188 0.07625 non-essential 0.233 non-essential high NA medium_confidence NP_214989.1 47.0 0.82217 67.514 Strong candidate ESM-2 calibrated P(essential)=0.076; HANSEN integrated essentiality score=0.233; ProteomeLM contextual percentile=0.822; target-priority score=67.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 252 ML2035 Q9CBF6 ML2035 Uncharacterized protein 87 0.03604 non-essential 0.23284 non-essential high NA medium_confidence 0.99499 71.159 Strong candidate ESM-2 calibrated P(essential)=0.036; HANSEN integrated essentiality score=0.233; ProteomeLM contextual percentile=0.995; target-priority score=71.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 253 ML0857 Q7AQE8 ML0857 Membrane protein 250 0.19217 non-essential 0.23259 non-essential high NA medium_confidence NP_216735.1 80.8 0.33062 52.99 Moderate candidate ESM-2 calibrated P(essential)=0.192; HANSEN integrated essentiality score=0.233; ProteomeLM contextual percentile=0.331; target-priority score=53.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 254 ML2091 Q9CBE6 ML2091 Uncharacterized protein 61 0.04985 non-essential 0.2324 non-essential high NA medium_confidence 0.93175 70.251 Strong candidate ESM-2 calibrated P(essential)=0.050; HANSEN integrated essentiality score=0.232; ProteomeLM contextual percentile=0.932; target-priority score=70.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 255 ML2244 Q9CBC0 ML2244 Uncharacterized protein 113 0.03486 non-essential 0.2319 non-essential high NA medium_confidence 0.99311 71.751 Strong candidate ESM-2 calibrated P(essential)=0.035; HANSEN integrated essentiality score=0.232; ProteomeLM contextual percentile=0.993; target-priority score=71.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 256 ML1938 Q9X781 ispH lytB lytB2 ML1938 MLCB1222.06c 4-hydroxy-3-methylbut-2-enyl diphosphate reductase (HMBPP reductase) (EC 1.17.7.4) 332 0.19217 non-essential 0.23177 non-essential high NA medium_confidence YP_177788.1 82.9 0.28303 67.52 Strong candidate ESM-2 calibrated P(essential)=0.192; HANSEN integrated essentiality score=0.232; ProteomeLM contextual percentile=0.283; target-priority score=67.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 257 ML2121 Q7APY9 ML2121 Uncharacterized protein 136 0.05162 non-essential 0.23136 non-essential high NA medium_confidence 0.91359 71.563 Strong candidate ESM-2 calibrated P(essential)=0.052; HANSEN integrated essentiality score=0.231; ProteomeLM contextual percentile=0.914; target-priority score=71.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 258 ML1189 Q7AQ87 ML1189 Uncharacterized protein 127 0.03486 non-essential 0.23127 non-essential high NA medium_confidence 0.97808 75.61 Strong candidate ESM-2 calibrated P(essential)=0.035; HANSEN integrated essentiality score=0.231; ProteomeLM contextual percentile=0.978; target-priority score=75.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 259 ML0104 Q9CDA9 embB ML0104 Probable arabinosyltransferase B (EC 2.4.2.-) 1083 0.09187 non-essential 0.23105 non-essential high NA medium_confidence NP_218312.1 79.1 0.71885 74.367 Strong candidate ESM-2 calibrated P(essential)=0.092; HANSEN integrated essentiality score=0.231; ProteomeLM contextual percentile=0.719; target-priority score=74.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:45Z 260 ML1848 O32994 rplX ML1848 MLCB2492.15 Large ribosomal subunit protein uL24 (50S ribosomal protein L24) 105 0.19764 non-essential 0.23072 non-essential high NA medium_confidence NP_215229.1 93.3 0.28679 55.604 Moderate candidate ESM-2 calibrated P(essential)=0.198; HANSEN integrated essentiality score=0.231; ProteomeLM contextual percentile=0.287; target-priority score=55.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 261 ML1409 Q9CC12 argD ML1409 Acetylornithine aminotransferase (ACOAT) (EC 2.6.1.11) 404 0.10418 non-essential 0.23065 non-essential high NA medium_confidence NP_216171.1 82.9 0.64371 79.926 Strong candidate ESM-2 calibrated P(essential)=0.104; HANSEN integrated essentiality score=0.231; ProteomeLM contextual percentile=0.644; target-priority score=79.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 262 ML1637 Q7AQ37 ML1637 RNase H type-1 domain-containing protein 371 0.09201 non-essential 0.23061 non-essential high NA medium_confidence NP_216744.1 77.1 0.72511 71.157 Strong candidate ESM-2 calibrated P(essential)=0.092; HANSEN integrated essentiality score=0.231; ProteomeLM contextual percentile=0.725; target-priority score=71.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 263 ML1243 Q9CC60 ML1243 Uncharacterized protein 153 0.03898 non-essential 0.23048 non-essential high NA medium_confidence 0.96556 71.847 Strong candidate ESM-2 calibrated P(essential)=0.039; HANSEN integrated essentiality score=0.230; ProteomeLM contextual percentile=0.966; target-priority score=71.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 264 ML2669 Q7APS4 ML2669 Uncharacterized protein 106 0.03486 non-essential 0.23042 non-essential high NA medium_confidence 0.98121 72.836 Strong candidate ESM-2 calibrated P(essential)=0.035; HANSEN integrated essentiality score=0.230; ProteomeLM contextual percentile=0.981; target-priority score=72.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 265 ML1086 Q9CCA3 ML1086 Probable solute-binding transport lipoprotein 468 0.06981 non-essential 0.23019 non-essential high NA medium_confidence NP_215751.1 77.8 0.81904 73.0 Strong candidate ESM-2 calibrated P(essential)=0.070; HANSEN integrated essentiality score=0.230; ProteomeLM contextual percentile=0.819; target-priority score=73.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 266 ML2476 Q9CB31 ML2476 Uncharacterized protein 55 0.03579 non-essential 0.23017 non-essential high NA medium_confidence 0.97683 72.385 Strong candidate ESM-2 calibrated P(essential)=0.036; HANSEN integrated essentiality score=0.230; ProteomeLM contextual percentile=0.977; target-priority score=72.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 267 ML2353 Q49934 ML2353 Phenolphthiocerol/phthiocerol polyketide synthase subunit E (EC 2.3.1.292) ((Phenol)carboxyphthiodiolenone synthase subunit E) (Beta-ketoacyl-acyl-carrier-protein synthase I) (Phthiocerol synthesis polyketide synthase type I PpsE) 1489 0.06543 non-essential 0.23016 non-essential high NA medium_confidence NP_217451.1 82.0 0.80714 83.821 High-priority ESM-2 calibrated P(essential)=0.065; HANSEN integrated essentiality score=0.230; ProteomeLM contextual percentile=0.807; target-priority score=83.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:45Z 268 ML0525 Q9CCR7 ML0525 Uncharacterized protein 58 0.03466 non-essential 0.23013 non-essential high NA medium_confidence 0.98372 71.725 Strong candidate ESM-2 calibrated P(essential)=0.035; HANSEN integrated essentiality score=0.230; ProteomeLM contextual percentile=0.984; target-priority score=71.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 269 ML2242 Q7APX2 ML2242 Uncharacterized protein 243 0.04985 non-essential 0.23 non-essential high NA medium_confidence 0.91171 72.265 Strong candidate ESM-2 calibrated P(essential)=0.050; HANSEN integrated essentiality score=0.230; ProteomeLM contextual percentile=0.912; target-priority score=72.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 270 ML0842 O32975 cyd csd1 ML0842 MLCB22.44c Probable cysteine desulfurase 1 (EC 2.8.1.7) 611 0.09638 non-essential 0.22984 non-essential high NA medium_confidence 0.68065 77.903 Strong candidate ESM-2 calibrated P(essential)=0.096; HANSEN integrated essentiality score=0.230; ProteomeLM contextual percentile=0.681; target-priority score=77.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 271 ML1724 Q9CBQ8 ML1724 Enoyl-CoA hydratase/isomerase 252 0.14132 non-essential 0.22956 non-essential high NA medium_confidence NP_217555.1 85.6 0.51409 63.876 Moderate candidate ESM-2 calibrated P(essential)=0.141; HANSEN integrated essentiality score=0.230; ProteomeLM contextual percentile=0.514; target-priority score=63.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 272 ML1470 Q9CBY9 ML1470 Conserved membrane protein 123 0.07625 non-essential 0.22951 non-essential high NA medium_confidence NP_216962.1 66.7 0.79712 69.064 Strong candidate ESM-2 calibrated P(essential)=0.076; HANSEN integrated essentiality score=0.230; ProteomeLM contextual percentile=0.797; target-priority score=69.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 273 ML2308 Q9CB85 pon1 ML2308 Penicillin binding protein (Class A) 803 0.14132 non-essential 0.2295 non-essential high NA medium_confidence YP_178005.1 87.4 0.50407 67.163 Strong candidate ESM-2 calibrated P(essential)=0.141; HANSEN integrated essentiality score=0.230; ProteomeLM contextual percentile=0.504; target-priority score=67.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:45Z 274 ML0188 Q9CD63 ML0188 DUF5642 domain-containing protein 87 0.04552 non-essential 0.2294 non-essential high NA medium_confidence 0.93363 70.346 Strong candidate ESM-2 calibrated P(essential)=0.046; HANSEN integrated essentiality score=0.229; ProteomeLM contextual percentile=0.934; target-priority score=70.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 275 ML2441 P53531 gpmA gpm pgm ML2441 B2168_C3_246 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase (BPG-dependent PGAM) (PGAM) (Phosphoglyceromutase) (dPGM) (EC 5.4.2.11) 247 0.09187 non-essential 0.22929 non-essential high NA medium_confidence YP_177731.1 89.0 0.68817 81.291 High-priority ESM-2 calibrated P(essential)=0.092; HANSEN integrated essentiality score=0.229; ProteomeLM contextual percentile=0.688; target-priority score=81.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 276 ML0230 O69524 panC ML0230 MLCB2548.01c Pantothenate synthetase (PS) (EC 6.3.2.1) (Pantoate--beta-alanine ligase) (Pantoate-activating enzyme) 313 0.08519 non-essential 0.22927 non-essential high NA medium_confidence NP_218119.1 79.8 0.71509 82.505 High-priority ESM-2 calibrated P(essential)=0.085; HANSEN integrated essentiality score=0.229; ProteomeLM contextual percentile=0.715; target-priority score=82.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 277 ML1286 Q9CC47 ML1286 Transcriptional regulatory protein PdtaR 205 0.12863 non-essential 0.229 non-essential high NA medium_confidence NP_216142.1 90.7 0.56982 63.598 Moderate candidate ESM-2 calibrated P(essential)=0.129; HANSEN integrated essentiality score=0.229; ProteomeLM contextual percentile=0.570; target-priority score=63.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 278 ML2450 Q9CB46 ML2450 Possible secreted protein 245 0.08334 non-essential 0.22851 non-essential high NA medium_confidence NP_214993.1 70.0 0.7608 68.343 Strong candidate ESM-2 calibrated P(essential)=0.083; HANSEN integrated essentiality score=0.229; ProteomeLM contextual percentile=0.761; target-priority score=68.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 279 ML0897 Q7AQD3 ML0897 non-specific serine/threonine protein kinase (EC 2.7.11.1) 400 0.10115 non-essential 0.2282 non-essential high NA medium_confidence NP_216692.1 75.3 0.665 72.511 Strong candidate ESM-2 calibrated P(essential)=0.101; HANSEN integrated essentiality score=0.228; ProteomeLM contextual percentile=0.665; target-priority score=72.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 280 ML1143 P45825 atpA ML1143 ATP synthase subunit alpha (EC 7.1.2.2) (ATP synthase F1 sector subunit alpha) (F-ATPase subunit alpha) 558 0.23815 non-essential 0.2281 non-essential medium NA medium_confidence NP_215824.1 90.3 0.0814 57.009 Moderate candidate ESM-2 calibrated P(essential)=0.238; HANSEN integrated essentiality score=0.228; ProteomeLM contextual percentile=0.081; target-priority score=57.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 281 ML0473 Q9CCT6 ML0473 Uncharacterized protein 90 0.04985 non-essential 0.2281 non-essential high NA medium_confidence 0.90858 69.514 Strong candidate ESM-2 calibrated P(essential)=0.050; HANSEN integrated essentiality score=0.228; ProteomeLM contextual percentile=0.909; target-priority score=69.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 282 ML2487 Q9CB28 pyrE ML2487 Orotate phosphoribosyltransferase (OPRT) (OPRTase) (EC 2.4.2.10) 179 0.12597 non-essential 0.22797 non-essential high NA medium_confidence YP_177723.1 85.4 0.53976 75.893 Strong candidate ESM-2 calibrated P(essential)=0.126; HANSEN integrated essentiality score=0.228; ProteomeLM contextual percentile=0.540; target-priority score=75.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 283 ML2249 Q9CBB9 ML2249 Uncharacterized protein 105 0.04897 non-essential 0.22771 non-essential high NA medium_confidence 0.91484 67.982 Strong candidate ESM-2 calibrated P(essential)=0.049; HANSEN integrated essentiality score=0.228; ProteomeLM contextual percentile=0.915; target-priority score=68.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 284 ML1845 O32997 rpsH ML1845 MLCB2492.18 Small ribosomal subunit protein uS8 (30S ribosomal protein S8) 132 0.16674 non-essential 0.22741 non-essential high NA medium_confidence NP_215232.1 93.9 0.39324 60.992 Moderate candidate ESM-2 calibrated P(essential)=0.167; HANSEN integrated essentiality score=0.227; ProteomeLM contextual percentile=0.393; target-priority score=61.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 285 ML0806 Q9CCH6 ML0806 Membrane protein 173 0.08115 non-essential 0.22736 non-essential high NA medium_confidence NP_217733.1 77.1 0.76644 67.537 Strong candidate ESM-2 calibrated P(essential)=0.081; HANSEN integrated essentiality score=0.227; ProteomeLM contextual percentile=0.766; target-priority score=67.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 286 ML1424 Q7AQ54 ML1424 Trehalose import ATP-binding protein SugC (Nucleotide-binding domain of SugABC transporter) (SugABC transporter ATPase SugC) 356 0.13353 non-essential 0.22733 non-essential high NA medium_confidence NP_216554.1 79.7 0.53287 65.187 Strong candidate ESM-2 calibrated P(essential)=0.134; HANSEN integrated essentiality score=0.227; ProteomeLM contextual percentile=0.533; target-priority score=65.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 287 ML2655 Q05862 fbpC fbpC2 ML2655 Diacylglycerol acyltransferase/mycolyltransferase Ag85C (DGAT) (EC 2.3.1.122) (EC 2.3.1.20) (Acyl-CoA:diacylglycerol acyltransferase) (Antigen 85 complex C) (85C) (Ag85C) (Fibronectin-binding protein C) (Fbps C) 333 0.09165 non-essential 0.2273 non-essential high NA medium_confidence YP_177694.1 82.1 0.68879 77.436 Strong candidate ESM-2 calibrated P(essential)=0.092; HANSEN integrated essentiality score=0.227; ProteomeLM contextual percentile=0.689; target-priority score=77.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 288 ML1996 Q7AQ07 nrp ML1996 Probable peptide synthase 1401 0.09148 non-essential 0.22705 non-essential high NA medium_confidence NP_214615.1 68.9 0.71321 68.889 Strong candidate ESM-2 calibrated P(essential)=0.091; HANSEN integrated essentiality score=0.227; ProteomeLM contextual percentile=0.713; target-priority score=68.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:45Z 289 ML1603 Q9CBT8 ML1603 Uncharacterized protein 86 0.04563 non-essential 0.22679 non-essential high NA medium_confidence 0.9211 69.213 Strong candidate ESM-2 calibrated P(essential)=0.046; HANSEN integrated essentiality score=0.227; ProteomeLM contextual percentile=0.921; target-priority score=69.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 290 ML0074 Q9CDC5 glpQ ML0074 Glycerophosphoryl diester phosphodiesterase (EC 3.1.4.46) 271 0.09638 non-essential 0.22645 non-essential high NA medium_confidence NP_218359.1 87.9 0.67627 72.605 Strong candidate ESM-2 calibrated P(essential)=0.096; HANSEN integrated essentiality score=0.226; ProteomeLM contextual percentile=0.676; target-priority score=72.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 291 ML2615 Q7APT1 ML2615 Probable membrane protein 229 0.06716 non-essential 0.22607 non-essential high NA medium_confidence NP_214714.1 74.7 0.8109 71.669 Strong candidate ESM-2 calibrated P(essential)=0.067; HANSEN integrated essentiality score=0.226; ProteomeLM contextual percentile=0.811; target-priority score=71.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 292 ML0240 Q9CD53 ML0240 Resuscitation-promoting factor RpfB 375 0.13353 non-essential 0.2259 non-essential high NA medium_confidence NP_215525.1 82.7 0.53037 63.173 Moderate candidate ESM-2 calibrated P(essential)=0.134; HANSEN integrated essentiality score=0.226; ProteomeLM contextual percentile=0.530; target-priority score=63.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 293 ML0472 Q9CCT7 ML0472 Uncharacterized protein 80 0.0327 non-essential 0.22567 non-essential high NA medium_confidence 0.96744 71.405 Strong candidate ESM-2 calibrated P(essential)=0.033; HANSEN integrated essentiality score=0.226; ProteomeLM contextual percentile=0.967; target-priority score=71.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 294 ML1907 Q9CBJ9 secE ML1907 Protein translocase subunit SecE 146 0.1873 non-essential 0.22543 non-essential high NA medium_confidence YP_177743.1 56.2 0.3181 50.53 Moderate candidate ESM-2 calibrated P(essential)=0.187; HANSEN integrated essentiality score=0.225; ProteomeLM contextual percentile=0.318; target-priority score=50.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 295 ML1942 Q7AQ16 ML1942 Probable cholesterol dehydrogenase 376 0.10115 non-essential 0.22502 non-essential high NA medium_confidence NP_215622.1 75.5 0.65498 69.561 Strong candidate ESM-2 calibrated P(essential)=0.101; HANSEN integrated essentiality score=0.225; ProteomeLM contextual percentile=0.655; target-priority score=69.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 296 ML1323 Q9S375 prcA ML1323 B2126_C3_260 Proteasome subunit alpha (20S proteasome alpha subunit) (Proteasome core protein PrcA) 265 0.10418 non-essential 0.22496 non-essential high NA medium_confidence NP_216625.1 91.8 0.63995 69.828 Strong candidate ESM-2 calibrated P(essential)=0.104; HANSEN integrated essentiality score=0.225; ProteomeLM contextual percentile=0.640; target-priority score=69.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 297 ML0535 Q9CCR3 carA ML0535 Carbamoyl phosphate synthase small chain (EC 6.3.5.5) (Carbamoyl phosphate synthetase glutamine chain) 375 0.23815 non-essential 0.22493 non-essential medium NA medium_confidence NP_215899.1 85.7 0.05636 59.194 Moderate candidate ESM-2 calibrated P(essential)=0.238; HANSEN integrated essentiality score=0.225; ProteomeLM contextual percentile=0.056; target-priority score=59.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 298 ML0757 Q9CCK3 ML0757 Uncharacterized protein 230 0.05422 non-essential 0.22492 non-essential high NA medium_confidence 0.85911 73.163 Strong candidate ESM-2 calibrated P(essential)=0.054; HANSEN integrated essentiality score=0.225; ProteomeLM contextual percentile=0.859; target-priority score=73.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 299 ML1811 Q9CBL6 ML1811 Exported p60 protein homologue 241 0.06311 non-essential 0.22476 non-essential high NA medium_confidence NP_215994.1 77.1 0.82279 71.313 Strong candidate ESM-2 calibrated P(essential)=0.063; HANSEN integrated essentiality score=0.225; ProteomeLM contextual percentile=0.823; target-priority score=71.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 300 ML2059 Q7AQ00 ML2059 Short-chain dehydrogenase/reductase family 224 0.09638 non-essential 0.22472 non-essential high NA medium_confidence NP_216372.1 80.4 0.67439 69.786 Strong candidate ESM-2 calibrated P(essential)=0.096; HANSEN integrated essentiality score=0.225; ProteomeLM contextual percentile=0.674; target-priority score=69.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 301 ML0863 Q7AQE5 ML0863 Uncharacterized protein 104 0.03466 non-essential 0.2245 non-essential high NA medium_confidence 0.95429 70.467 Strong candidate ESM-2 calibrated P(essential)=0.035; HANSEN integrated essentiality score=0.224; ProteomeLM contextual percentile=0.954; target-priority score=70.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 302 ML1891 P30760 rpoB ML1891 DNA-directed RNA polymerase subunit beta (RNAP subunit beta) (EC 2.7.7.6) (RNA polymerase subunit beta) (Transcriptase subunit beta) 1178 0.23815 non-essential 0.22433 non-essential medium NA medium_confidence NP_215181.1 94.9 0.067 54.371 Moderate candidate ESM-2 calibrated P(essential)=0.238; HANSEN integrated essentiality score=0.224; ProteomeLM contextual percentile=0.067; target-priority score=54.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:45Z 303 ML0953 Q9CCC9 ML0953 Uncharacterized protein 79 0.04176 non-essential 0.22411 non-essential high NA medium_confidence 0.91797 70.958 Strong candidate ESM-2 calibrated P(essential)=0.042; HANSEN integrated essentiality score=0.224; ProteomeLM contextual percentile=0.918; target-priority score=71.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 304 ML0448 Q7AQJ2 ML0448 Uncharacterized protein 90 0.024 non-essential 0.22402 non-essential high NA medium_confidence 0.9975 71.453 Strong candidate ESM-2 calibrated P(essential)=0.024; HANSEN integrated essentiality score=0.224; ProteomeLM contextual percentile=0.997; target-priority score=71.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 305 ML1821 Q9CBL0 ML1821 Uncharacterized protein 117 0.02561 non-essential 0.22391 non-essential high NA medium_confidence 0.98497 72.985 Strong candidate ESM-2 calibrated P(essential)=0.026; HANSEN integrated essentiality score=0.224; ProteomeLM contextual percentile=0.985; target-priority score=73.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 306 ML0319 Q9ZBM7 lpqE ML0319 MLCB1450.02 Putative lipoprotein LpqE 183 0.04618 non-essential 0.2239 non-essential high NA medium_confidence NP_218101.1 67.3 0.88917 73.443 Strong candidate ESM-2 calibrated P(essential)=0.046; HANSEN integrated essentiality score=0.224; ProteomeLM contextual percentile=0.889; target-priority score=73.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 307 ML1835 Q7AQ21 ML1835 N-acetyltransferase domain-containing protein 227 0.04985 non-essential 0.22384 non-essential high NA medium_confidence NP_215244.1 80.3 0.86224 76.761 Strong candidate ESM-2 calibrated P(essential)=0.050; HANSEN integrated essentiality score=0.224; ProteomeLM contextual percentile=0.862; target-priority score=76.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 308 ML1829 Q9CBK9 ML1829 Uncharacterized protein 125 0.03079 non-essential 0.22379 non-essential high NA medium_confidence 0.96118 72.753 Strong candidate ESM-2 calibrated P(essential)=0.031; HANSEN integrated essentiality score=0.224; ProteomeLM contextual percentile=0.961; target-priority score=72.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 309 ML0574 Q7AQI4 ML0574 Uncharacterized protein 105 0.02386 non-essential 0.22347 non-essential high NA medium_confidence 0.99624 71.002 Strong candidate ESM-2 calibrated P(essential)=0.024; HANSEN integrated essentiality score=0.223; ProteomeLM contextual percentile=0.996; target-priority score=71.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 310 ML0241 Q9CD52 rsmA ksgA ML0241 Ribosomal RNA small subunit methyltransferase A (EC 2.1.1.182) (16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase) (16S rRNA dimethyladenosine transferase) (16S rRNA dimethylase) (S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase) 306 0.08969 non-essential 0.22314 non-essential high NA medium_confidence NP_215526.1 85.0 0.67188 77.908 Strong candidate ESM-2 calibrated P(essential)=0.090; HANSEN integrated essentiality score=0.223; ProteomeLM contextual percentile=0.672; target-priority score=77.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 311 ML0659 Q7AQH0 ML0659 Uncharacterized protein 108 0.0309 non-essential 0.2231 non-essential high NA medium_confidence 0.96493 69.917 Strong candidate ESM-2 calibrated P(essential)=0.031; HANSEN integrated essentiality score=0.223; ProteomeLM contextual percentile=0.965; target-priority score=69.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 312 ML2083 Q7APZ1 ilvG ML2083 acetolactate synthase (EC 2.2.1.6) 548 0.09638 non-essential 0.22306 non-essential high NA medium_confidence NP_216336.1 86.1 0.64245 77.328 Strong candidate ESM-2 calibrated P(essential)=0.096; HANSEN integrated essentiality score=0.223; ProteomeLM contextual percentile=0.642; target-priority score=77.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 313 ML1733 Q9CBQ1 ML1733 TetR-family transcriptional regulator 275 0.05827 non-essential 0.22299 non-essential high NA medium_confidence NP_217566.1 86.6 0.83281 71.917 Strong candidate ESM-2 calibrated P(essential)=0.058; HANSEN integrated essentiality score=0.223; ProteomeLM contextual percentile=0.833; target-priority score=71.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 314 ML0067 Q9CDD1 hns ML0067 Histone-like protein 121 0.04985 non-essential 0.2227 non-essential high NA medium_confidence NP_218369.1 57.5 0.87852 68.939 Strong candidate ESM-2 calibrated P(essential)=0.050; HANSEN integrated essentiality score=0.223; ProteomeLM contextual percentile=0.879; target-priority score=68.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 315 ML1454 Q9CBZ8 nadD ML1454 Probable nicotinate-nucleotide adenylyltransferase (EC 2.7.7.18) (Deamido-NAD(+) diphosphorylase) (Deamido-NAD(+) pyrophosphorylase) (Nicotinate mononucleotide adenylyltransferase) (NaMN adenylyltransferase) 214 0.23687 non-essential 0.22264 non-essential medium NA medium_confidence NP_216937.1 80.2 0.0551 57.02 Moderate candidate ESM-2 calibrated P(essential)=0.237; HANSEN integrated essentiality score=0.223; ProteomeLM contextual percentile=0.055; target-priority score=57.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 316 ML2677 Q7APS2 ML2677 TetR-family transcriptional regulator 236 0.02929 non-essential 0.22261 non-essential high NA medium_confidence NP_214592.1 71.4 0.95241 75.711 Strong candidate ESM-2 calibrated P(essential)=0.029; HANSEN integrated essentiality score=0.223; ProteomeLM contextual percentile=0.952; target-priority score=75.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 317 ML1604 Q9CBT7 ML1604 Uncharacterized protein 129 0.02734 non-essential 0.22251 non-essential high NA medium_confidence 0.97307 71.51 Strong candidate ESM-2 calibrated P(essential)=0.027; HANSEN integrated essentiality score=0.223; ProteomeLM contextual percentile=0.973; target-priority score=71.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 318 ML0773 Q9CCJ2 mtrA ML0773 DNA-binding response regulator MtrA 225 0.12863 non-essential 0.22232 non-essential high NA medium_confidence NP_217763.1 99.1 0.53413 62.377 Moderate candidate ESM-2 calibrated P(essential)=0.129; HANSEN integrated essentiality score=0.222; ProteomeLM contextual percentile=0.534; target-priority score=62.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 319 ML2377 P54880 ML2377 u1740w Probable transport accessory protein MmpS4 154 0.08425 non-essential 0.22231 non-essential high NA medium_confidence NP_214965.1 75.0 0.72198 67.729 Strong candidate ESM-2 calibrated P(essential)=0.084; HANSEN integrated essentiality score=0.222; ProteomeLM contextual percentile=0.722; target-priority score=67.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 320 ML1955 Q9X796 truA ML1955 MLCB1222.25c tRNA pseudouridine synthase A (EC 5.4.99.12) (tRNA pseudouridine(38-40) synthase) (tRNA pseudouridylate synthase I) (tRNA-uridine isomerase I) 286 0.09201 non-essential 0.22228 non-essential high NA medium_confidence NP_217972.3 77.6 0.65936 76.845 Strong candidate ESM-2 calibrated P(essential)=0.092; HANSEN integrated essentiality score=0.222; ProteomeLM contextual percentile=0.659; target-priority score=76.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 321 ML1503 Q9CBX1 ML1503.1 ML1503A Putative pterin-4-alpha-carbinolamine dehydratase (PHS) (EC 4.2.1.96) (4-alpha-hydroxy-tetrahydropterin dehydratase) (Pterin carbinolamine dehydratase) (PCD) 94 0.07502 non-essential 0.22222 non-essential high NA medium_confidence YP_177641.1 71.0 0.73826 76.391 Strong candidate ESM-2 calibrated P(essential)=0.075; HANSEN integrated essentiality score=0.222; ProteomeLM contextual percentile=0.738; target-priority score=76.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 322 ML0485 P40829 gabT ML0485 B1177_F2_67 MLCB1259.03c 4-aminobutyrate aminotransferase (EC 2.6.1.19) ((S)-3-amino-2-methylpropionate transaminase) (EC 2.6.1.22) (GABA aminotransferase) (GABA-AT) (Gamma-amino-N-butyrate transaminase) (GABA transaminase) (Glutamate:succinic semialdehyde transaminase) (L-AIBAT) 446 0.14132 non-essential 0.22208 non-essential high NA medium_confidence NP_217105.1 84.2 0.44959 70.834 Strong candidate ESM-2 calibrated P(essential)=0.141; HANSEN integrated essentiality score=0.222; ProteomeLM contextual percentile=0.450; target-priority score=70.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 323 ML0963 Q9CCC4 ML0963 Uncharacterized protein 154 0.02095 non-essential 0.222 non-essential high NA medium_confidence 0.99937 71.519 Strong candidate ESM-2 calibrated P(essential)=0.021; HANSEN integrated essentiality score=0.222; ProteomeLM contextual percentile=0.999; target-priority score=71.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 324 ML0840 Q7AQF3 ML0840 Thioester domain-containing protein 434 0.03949 non-essential 0.22195 non-essential high NA medium_confidence 0.90795 73.595 Strong candidate ESM-2 calibrated P(essential)=0.039; HANSEN integrated essentiality score=0.222; ProteomeLM contextual percentile=0.908; target-priority score=73.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 325 ML0923 Q9CCD9 ML0923 Possible membrane protein 130 0.04805 non-essential 0.22189 non-essential high NA medium_confidence NP_216660.1 50.4 0.88165 69.063 Strong candidate ESM-2 calibrated P(essential)=0.048; HANSEN integrated essentiality score=0.222; ProteomeLM contextual percentile=0.882; target-priority score=69.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 326 ML2264 Q9CBB4 ML2264 Uncharacterized protein 203 0.01889 non-essential 0.22178 non-essential high NA medium_confidence 0.99875 74.517 Strong candidate ESM-2 calibrated P(essential)=0.019; HANSEN integrated essentiality score=0.222; ProteomeLM contextual percentile=0.999; target-priority score=74.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 327 ML0728 P46700 sseA ML0728 B1308_C1_127 Putative thiosulfate sulfurtransferase SseA (EC 2.8.1.1) 296 0.13453 non-essential 0.22166 non-essential high NA medium_confidence NP_217800.1 83.8 0.47902 70.593 Strong candidate ESM-2 calibrated P(essential)=0.135; HANSEN integrated essentiality score=0.222; ProteomeLM contextual percentile=0.479; target-priority score=70.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 328 ML2113 Q50123 ML2113 Toxin 181 0.05001 non-essential 0.22119 non-essential high NA medium_confidence NP_215425.1 83.9 0.86099 71.642 Strong candidate ESM-2 calibrated P(essential)=0.050; HANSEN integrated essentiality score=0.221; ProteomeLM contextual percentile=0.861; target-priority score=71.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 329 ML0136 Q9CD80 lppX ML0136 Putative phthiocerol dimycocerosate transporter LppX (Lipoprotein LppX) 233 0.03861 non-essential 0.22107 non-essential high NA medium_confidence NP_217461.1 77.1 0.90232 75.11 Strong candidate ESM-2 calibrated P(essential)=0.039; HANSEN integrated essentiality score=0.221; ProteomeLM contextual percentile=0.902; target-priority score=75.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 330 ML2359 Q9Z5K4 tesA ML2359 MLCB12.04c Thioesterase TesA (EC 3.1.2.-) 261 0.04805 non-essential 0.22077 non-essential high NA medium_confidence NP_217444.1 73.2 0.83782 81.716 High-priority ESM-2 calibrated P(essential)=0.048; HANSEN integrated essentiality score=0.221; ProteomeLM contextual percentile=0.838; target-priority score=81.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 331 ML1918 Q9CBJ2 ML1918 Conserved hypothetical membrane protein 263 0.05422 non-essential 0.22064 non-essential high NA medium_confidence NP_218104.1 79.7 0.84408 69.697 Strong candidate ESM-2 calibrated P(essential)=0.054; HANSEN integrated essentiality score=0.221; ProteomeLM contextual percentile=0.844; target-priority score=69.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 332 ML1425 Q7AQ53 ML1425 Probable ABC-transport protein, inner membrane component 283 0.06199 non-essential 0.22063 non-essential high NA medium_confidence NP_216555.1 79.2 0.80526 70.772 Strong candidate ESM-2 calibrated P(essential)=0.062; HANSEN integrated essentiality score=0.221; ProteomeLM contextual percentile=0.805; target-priority score=70.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 333 ML2682 P46385 rplI ML2682 MLCB1913.18c Large ribosomal subunit protein bL9 (50S ribosomal protein L9) 152 0.10977 non-essential 0.22021 non-essential high NA medium_confidence NP_214570.1 88.7 0.59361 67.351 Strong candidate ESM-2 calibrated P(essential)=0.110; HANSEN integrated essentiality score=0.220; ProteomeLM contextual percentile=0.594; target-priority score=67.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 334 ML0098 Q05868 mpt51 ML0098 MPT51 antigen 301 0.06528 non-essential 0.22016 non-essential high NA medium_confidence YP_178017.1 77.8 0.78084 73.006 Strong candidate ESM-2 calibrated P(essential)=0.065; HANSEN integrated essentiality score=0.220; ProteomeLM contextual percentile=0.781; target-priority score=73.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 335 ML0979 Q7AQC0 ML0979 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase (EC 2.7.8.5) 193 0.0503 non-essential 0.22009 non-essential high NA medium_confidence NP_217262.1 76.6 0.8253 81.108 High-priority ESM-2 calibrated P(essential)=0.050; HANSEN integrated essentiality score=0.220; ProteomeLM contextual percentile=0.825; target-priority score=81.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 336 ML1597 O33039 tsf ML1597 MLCB250.64 Elongation factor Ts (EF-Ts) 276 0.13353 non-essential 0.22006 non-essential high NA medium_confidence NP_217405.1 83.7 0.49906 62.132 Moderate candidate ESM-2 calibrated P(essential)=0.134; HANSEN integrated essentiality score=0.220; ProteomeLM contextual percentile=0.499; target-priority score=62.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 337 ML0536 Q9CCR2 carB ML0536 Carbamoyl phosphate synthase large chain (EC 6.3.4.16) (EC 6.3.5.5) (Carbamoyl phosphate synthetase ammonia chain) 1121 0.23815 non-essential 0.21978 non-essential medium NA medium_confidence YP_177804.1 88.9 0.03193 57.189 Moderate candidate ESM-2 calibrated P(essential)=0.238; HANSEN integrated essentiality score=0.220; ProteomeLM contextual percentile=0.032; target-priority score=57.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:45Z 338 ML1075 Q9CCA7 ML1075 Putative O-methyltransferase ML1075 (EC 2.1.1.-) 224 0.09638 non-essential 0.21972 non-essential high NA medium_confidence NP_215736.1 85.5 0.63369 73.636 Strong candidate ESM-2 calibrated P(essential)=0.096; HANSEN integrated essentiality score=0.220; ProteomeLM contextual percentile=0.634; target-priority score=73.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 339 ML2666 Q9CCY7 ML2666 Uncharacterized protein 84 0.03486 non-essential 0.21972 non-essential high NA medium_confidence 0.92862 69.326 Strong candidate ESM-2 calibrated P(essential)=0.035; HANSEN integrated essentiality score=0.220; ProteomeLM contextual percentile=0.929; target-priority score=69.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 340 ML1998 P53525 ML1998 o659 Uncharacterized protein ML1998 659 0.06411 non-essential 0.21949 non-essential high NA medium_confidence NP_214616.1 70.1 0.78647 71.567 Strong candidate ESM-2 calibrated P(essential)=0.064; HANSEN integrated essentiality score=0.219; ProteomeLM contextual percentile=0.786; target-priority score=71.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 341 ML0092 Q9CDB8 glf ML0092 UDP-galactopyranose mutase (EC 5.4.99.9) (UDP-GALP mutase) (Uridine 5-diphosphate galactopyranose mutase) 413 0.10418 non-essential 0.2192 non-essential high NA medium_confidence NP_218326.1 86.8 0.58798 75.981 Strong candidate ESM-2 calibrated P(essential)=0.104; HANSEN integrated essentiality score=0.219; ProteomeLM contextual percentile=0.588; target-priority score=76.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 342 ML0927 Q9CCD6 ML0927 Uncharacterized protein 102 0.024 non-essential 0.21908 non-essential high NA medium_confidence 0.96994 70.935 Strong candidate ESM-2 calibrated P(essential)=0.024; HANSEN integrated essentiality score=0.219; ProteomeLM contextual percentile=0.970; target-priority score=70.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 343 ML1575 Q9CBU8 ML1575 Uncharacterized protein 97 0.02041 non-essential 0.21895 non-essential high NA medium_confidence 0.98247 72.008 Strong candidate ESM-2 calibrated P(essential)=0.020; HANSEN integrated essentiality score=0.219; ProteomeLM contextual percentile=0.982; target-priority score=72.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 344 ML2337 Q7APW1 ML2337 Membrane protein 250 0.04985 non-essential 0.21889 non-essential high NA medium_confidence NP_218240.1 77.7 0.85473 69.403 Strong candidate ESM-2 calibrated P(essential)=0.050; HANSEN integrated essentiality score=0.219; ProteomeLM contextual percentile=0.855; target-priority score=69.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 345 ML1261 Q9CC56 priA hisA ML1261 MLCB1610.24 Phosphoribosyl isomerase A (1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase) (EC 5.3.1.16) (N-(5'-phosphoribosyl)anthranilate isomerase) (PRAI) (EC 5.3.1.24) (Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase) 244 0.10162 non-essential 0.21888 non-essential high NA medium_confidence NP_216119.1 84.8 0.59236 77.834 Strong candidate ESM-2 calibrated P(essential)=0.102; HANSEN integrated essentiality score=0.219; ProteomeLM contextual percentile=0.592; target-priority score=77.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 346 ML2402 O07137 echA8 ML2402 MLCB1306.05c Probable enoyl-CoA hydratase echA8 (EC 4.2.1.17) 257 0.09638 non-essential 0.2186 non-essential high NA medium_confidence NP_215586.1 86.4 0.62868 73.09 Strong candidate ESM-2 calibrated P(essential)=0.096; HANSEN integrated essentiality score=0.219; ProteomeLM contextual percentile=0.629; target-priority score=73.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 347 ML0292 Q9CCX2 ML0292 Uncharacterized protein 79 0.03864 non-essential 0.21851 non-essential high NA medium_confidence 0.9042 69.317 Strong candidate ESM-2 calibrated P(essential)=0.039; HANSEN integrated essentiality score=0.219; ProteomeLM contextual percentile=0.904; target-priority score=69.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 348 ML2392 Q9CB66 ML2392 Conserved membrane protein 144 0.06543 non-essential 0.21847 non-essential high NA medium_confidence NP_215597.1 69.0 0.7846 68.103 Strong candidate ESM-2 calibrated P(essential)=0.065; HANSEN integrated essentiality score=0.218; ProteomeLM contextual percentile=0.785; target-priority score=68.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 349 ML1816 Q9CBL2 ML1816 ABC transporter ATP-binding protein, possibly in EF-3 subfamily 545 0.09148 non-essential 0.21827 non-essential high NA medium_confidence NP_215989.1 88.1 0.66875 66.459 Strong candidate ESM-2 calibrated P(essential)=0.091; HANSEN integrated essentiality score=0.218; ProteomeLM contextual percentile=0.669; target-priority score=66.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 350 ML0450 O07145 pdxS ML0450 MLCL581.12c Pyridoxal 5'-phosphate synthase subunit PdxS (PLP synthase subunit PdxS) (EC 4.3.3.6) (Pdx1) 307 0.23815 non-essential 0.21816 non-essential medium NA medium_confidence NP_217122.1 89.7 0.01879 58.413 Moderate candidate ESM-2 calibrated P(essential)=0.238; HANSEN integrated essentiality score=0.218; ProteomeLM contextual percentile=0.019; target-priority score=58.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 351 ML2013 Q7AQ03 ML2013 Amidohydrolase-related domain-containing protein 126 0.03079 non-essential 0.21796 non-essential high NA medium_confidence 0.9186 75.563 Strong candidate ESM-2 calibrated P(essential)=0.031; HANSEN integrated essentiality score=0.218; ProteomeLM contextual percentile=0.919; target-priority score=75.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 352 ML1926 Q9CBI5 ML1926 Tuberculin related peptide (AT103) 167 0.11947 non-essential 0.21788 non-essential high NA medium_confidence NP_214945.1 62.7 0.55792 59.682 Moderate candidate ESM-2 calibrated P(essential)=0.119; HANSEN integrated essentiality score=0.218; ProteomeLM contextual percentile=0.558; target-priority score=59.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 353 ML0811 Q9CCH3 rhlE ML0811 RNA helicase (EC 3.6.4.13) 544 0.13829 non-essential 0.21778 non-essential high NA medium_confidence NP_217727.1 79.6 0.45961 63.569 Moderate candidate ESM-2 calibrated P(essential)=0.138; HANSEN integrated essentiality score=0.218; ProteomeLM contextual percentile=0.460; target-priority score=63.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 354 ML2581 Q9CD18 ML2581 Integral membrane protein 427 0.06628 non-essential 0.21774 non-essential high NA medium_confidence NP_214741.1 75.6 0.77646 68.092 Strong candidate ESM-2 calibrated P(essential)=0.066; HANSEN integrated essentiality score=0.218; ProteomeLM contextual percentile=0.776; target-priority score=68.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 355 ML2630 O06091 ML2630 MLCL622.28c Uncharacterized protein ML2630 123 0.03898 non-essential 0.21767 non-essential high NA medium_confidence 0.89919 68.793 Strong candidate ESM-2 calibrated P(essential)=0.039; HANSEN integrated essentiality score=0.218; ProteomeLM contextual percentile=0.899; target-priority score=68.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 356 ML0691 Q9CCM2 ML0691 D-alanyl-D-alanine carboxypeptidase 411 0.14132 non-essential 0.21733 non-essential high NA medium_confidence NP_217847.1 76.4 0.44208 63.892 Moderate candidate ESM-2 calibrated P(essential)=0.141; HANSEN integrated essentiality score=0.217; ProteomeLM contextual percentile=0.442; target-priority score=63.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 357 ML0955 Q7AQC2 ppdK ML0955 Pyruvate, phosphate dikinase 601 0.07935 non-essential 0.21726 non-essential high NA medium_confidence NP_215643.1 71.8 0.70946 69.522 Strong candidate ESM-2 calibrated P(essential)=0.079; HANSEN integrated essentiality score=0.217; ProteomeLM contextual percentile=0.709; target-priority score=69.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 358 ML1701 O33106 pfkA ML1701 MLCB637.14 ATP-dependent 6-phosphofructokinase (ATP-PFK) (Phosphofructokinase) (EC 2.7.1.11) (Phosphohexokinase) 343 0.14132 non-essential 0.21723 non-essential high NA medium_confidence NP_217526.1 90.4 0.41828 71.787 Strong candidate ESM-2 calibrated P(essential)=0.141; HANSEN integrated essentiality score=0.217; ProteomeLM contextual percentile=0.418; target-priority score=71.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 359 ML0917 Q9CCE4 ftsZ ML0917 Cell division protein FtsZ 379 0.23815 non-essential 0.21711 non-essential medium NA medium_confidence NP_216666.1 96.6 0.04008 49.09 Exploratory ESM-2 calibrated P(essential)=0.238; HANSEN integrated essentiality score=0.217; ProteomeLM contextual percentile=0.040; target-priority score=49.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 360 ML0475 Q49645 ML0475 B1177_C2_181 u1177b Probable transcriptional regulatory protein ML0475 251 0.13353 non-essential 0.2169 non-essential high NA medium_confidence NP_217119.1 92.4 0.48278 61.362 Moderate candidate ESM-2 calibrated P(essential)=0.134; HANSEN integrated essentiality score=0.217; ProteomeLM contextual percentile=0.483; target-priority score=61.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 361 ML0407 Q49730 ML0407 Secretion protein EspD 216 0.04656 non-essential 0.21686 non-essential high NA medium_confidence NP_218131.1 71.9 0.85848 69.204 Strong candidate ESM-2 calibrated P(essential)=0.047; HANSEN integrated essentiality score=0.217; ProteomeLM contextual percentile=0.858; target-priority score=69.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 362 ML0656 Q7AQH1 ML0656 Uncharacterized protein 93 0.01595 non-essential 0.21683 non-essential high NA medium_confidence 0.99249 71.336 Strong candidate ESM-2 calibrated P(essential)=0.016; HANSEN integrated essentiality score=0.217; ProteomeLM contextual percentile=0.992; target-priority score=71.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 363 ML1479 Q9CBY4 clpP2 ML1479 ATP-dependent Clp protease proteolytic subunit 2 (EC 3.4.21.92) (Endopeptidase Clp 2) 214 0.09625 non-essential 0.2168 non-essential high NA medium_confidence NP_216976.1 97.2 0.61365 74.806 Strong candidate ESM-2 calibrated P(essential)=0.096; HANSEN integrated essentiality score=0.217; ProteomeLM contextual percentile=0.614; target-priority score=74.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 364 ML2537 Q9CD28 eccA3 ML2537 ESX-3 secretion system protein EccA3 (ESX conserved component A3) (Type VII secretion system protein EccA3) (T7SS protein EccA3) 640 0.07063 non-essential 0.21676 non-essential high NA medium_confidence NP_214796.1 83.6 0.74076 71.478 Strong candidate ESM-2 calibrated P(essential)=0.071; HANSEN integrated essentiality score=0.217; ProteomeLM contextual percentile=0.741; target-priority score=71.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 365 ML0231 Q9CD57 panD ML0231 Aspartate 1-decarboxylase (EC 4.1.1.11) (Aspartate alpha-decarboxylase) [Cleaved into: Aspartate 1-decarboxylase beta chain; Aspartate 1-decarboxylase alpha chain] 142 0.07471 non-essential 0.21675 non-essential high NA medium_confidence NP_218118.1 82.9 0.69192 81.709 High-priority ESM-2 calibrated P(essential)=0.075; HANSEN integrated essentiality score=0.217; ProteomeLM contextual percentile=0.692; target-priority score=81.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 366 ML2567 Q9CD21 ML2567 Uncharacterized protein 159 0.03486 non-essential 0.21638 non-essential high NA medium_confidence 0.9092 69.248 Strong candidate ESM-2 calibrated P(essential)=0.035; HANSEN integrated essentiality score=0.216; ProteomeLM contextual percentile=0.909; target-priority score=69.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 367 ML2453 Q9CB43 ML2453 Uncharacterized protein ML2453 87 0.07625 non-essential 0.21637 non-essential high NA medium_confidence NP_214990.1 83.9 0.72135 68.538 Strong candidate ESM-2 calibrated P(essential)=0.076; HANSEN integrated essentiality score=0.216; ProteomeLM contextual percentile=0.721; target-priority score=68.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 368 ML2430 P46725 proC ML2430 B2168_C2_211 Pyrroline-5-carboxylate reductase (P5C reductase) (P5CR) (EC 1.5.1.2) (PCA reductase) 294 0.10196 non-essential 0.21636 non-essential high NA medium_confidence NP_215014.1 82.4 0.58234 75.661 Strong candidate ESM-2 calibrated P(essential)=0.102; HANSEN integrated essentiality score=0.216; ProteomeLM contextual percentile=0.582; target-priority score=75.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 369 ML0865 O32955 gcvT ML0865 MLCB22.13c Aminomethyltransferase (EC 2.1.2.10) (Glycine cleavage system T protein) 367 0.18523 non-essential 0.21635 non-essential high NA medium_confidence NP_216727.1 84.5 0.24296 61.139 Moderate candidate ESM-2 calibrated P(essential)=0.185; HANSEN integrated essentiality score=0.216; ProteomeLM contextual percentile=0.243; target-priority score=61.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 370 ML0204 Q7AQM0 rmlB2 ML0204 Sugar-nucleotide dehydratase 319 0.09638 non-essential 0.21634 non-essential high NA medium_confidence NP_215015.2 86.1 0.63557 66.225 Strong candidate ESM-2 calibrated P(essential)=0.096; HANSEN integrated essentiality score=0.216; ProteomeLM contextual percentile=0.636; target-priority score=66.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 371 ML0158 Q9CD70 ML0158 34 kDa antigen 314 0.03422 non-essential 0.21631 non-essential high NA medium_confidence NP_215469.1 48.4 0.91046 69.673 Strong candidate ESM-2 calibrated P(essential)=0.034; HANSEN integrated essentiality score=0.216; ProteomeLM contextual percentile=0.910; target-priority score=69.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 372 ML1906 Q9CBK0 nusG ML1906 Transcription termination/antitermination protein NusG 228 0.14132 non-essential 0.21599 non-essential high NA medium_confidence NP_215153.1 93.4 0.44897 58.874 Moderate candidate ESM-2 calibrated P(essential)=0.141; HANSEN integrated essentiality score=0.216; ProteomeLM contextual percentile=0.449; target-priority score=58.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 373 ML2503 Q9CB18 rfbA ML2503 Glucose-1-phosphate thymidylyltransferase (EC 2.7.7.24) 288 0.17556 non-essential 0.2158 non-essential high NA medium_confidence NP_214848.1 87.1 0.27489 64.269 Moderate candidate ESM-2 calibrated P(essential)=0.176; HANSEN integrated essentiality score=0.216; ProteomeLM contextual percentile=0.275; target-priority score=64.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 374 ML0669 Q7AQG5 ftsE ML0669 Cell division ATP-binding protein FtsE 229 0.17698 non-essential 0.21576 non-essential high NA medium_confidence NP_217618.1 91.7 0.29117 56.429 Moderate candidate ESM-2 calibrated P(essential)=0.177; HANSEN integrated essentiality score=0.216; ProteomeLM contextual percentile=0.291; target-priority score=56.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 375 ML0474 Q9CCT5 pdxT ML0474 Pyridoxal 5'-phosphate synthase subunit PdxT (EC 4.3.3.6) (Pdx2) (Pyridoxal 5'-phosphate synthase glutaminase subunit) (EC 3.5.1.2) 198 0.10233 non-essential 0.21553 non-essential high NA medium_confidence NP_217120.1 83.3 0.57044 77.47 Strong candidate ESM-2 calibrated P(essential)=0.102; HANSEN integrated essentiality score=0.216; ProteomeLM contextual percentile=0.570; target-priority score=77.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 376 ML1078 Q7AQ93 htrA ML1078 Possinble serine protease 533 0.05587 non-essential 0.21546 non-essential high NA medium_confidence NP_215739.2 81.8 0.80213 71.04 Strong candidate ESM-2 calibrated P(essential)=0.056; HANSEN integrated essentiality score=0.215; ProteomeLM contextual percentile=0.802; target-priority score=71.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 377 ML0160 Q7AQN4 purN ML0160 Phosphoribosylglycinamide formyltransferase (EC 2.1.2.2) (5'-phosphoribosylglycinamide transformylase) (GAR transformylase) (GART) 215 0.13353 non-essential 0.21543 non-essential high NA medium_confidence NP_215471.1 78.5 0.43895 73.309 Strong candidate ESM-2 calibrated P(essential)=0.134; HANSEN integrated essentiality score=0.215; ProteomeLM contextual percentile=0.439; target-priority score=73.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 378 ML0303 Q9CCX0 glnH ML0303 Glutamine-binding protein 326 0.0903 non-essential 0.21521 non-essential high NA medium_confidence NP_214925.1 79.3 0.6556 66.643 Strong candidate ESM-2 calibrated P(essential)=0.090; HANSEN integrated essentiality score=0.215; ProteomeLM contextual percentile=0.656; target-priority score=66.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 379 ML1949 Q9CBH8 ML1949 Uncharacterized protein 119 0.0357 non-essential 0.21505 non-essential high NA medium_confidence 0.90044 68.266 Strong candidate ESM-2 calibrated P(essential)=0.036; HANSEN integrated essentiality score=0.215; ProteomeLM contextual percentile=0.900; target-priority score=68.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 380 ML1577 Q9CBU6 ML1577 Probable penicillin binding protein 608 0.12863 non-essential 0.21504 non-essential high NA medium_confidence NP_217380.1 81.5 0.48967 62.933 Moderate candidate ESM-2 calibrated P(essential)=0.129; HANSEN integrated essentiality score=0.215; ProteomeLM contextual percentile=0.490; target-priority score=62.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 381 ML0881 O69583 qcrC ML0881 MLCB268.36 Cytochrome bc1 complex cytochrome c subunit (EC 7.1.1.8) (Cytochrome bc1 reductase complex subunit QcrC) (Ubiquinol--cytochrome c reductase cytochrome c subunit) 289 0.07947 non-essential 0.21498 non-essential high NA medium_confidence NP_216710.1 82.3 0.67752 75.63 Strong candidate ESM-2 calibrated P(essential)=0.079; HANSEN integrated essentiality score=0.215; ProteomeLM contextual percentile=0.678; target-priority score=75.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 382 ML1982 Q9CBH2 ML1982 Integral membrane protein 102 0.01709 non-essential 0.21478 non-essential high NA medium_confidence 0.97558 71.214 Strong candidate ESM-2 calibrated P(essential)=0.017; HANSEN integrated essentiality score=0.215; ProteomeLM contextual percentile=0.976; target-priority score=71.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 383 ML2030 Q9CBF8 ML2030 Resuscitation-promoting factor core lysozyme-like domain-containing protein 157 0.04552 non-essential 0.21464 non-essential high NA medium_confidence NP_216400.1 70.2 0.8397 72.754 Strong candidate ESM-2 calibrated P(essential)=0.046; HANSEN integrated essentiality score=0.215; ProteomeLM contextual percentile=0.840; target-priority score=72.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 384 ML2688 Q9CCY4 ponA ML2688 Penicillin-bonding protein 708 0.14132 non-essential 0.21438 non-essential high NA medium_confidence YP_177687.1 83.9 0.42204 64.799 Moderate candidate ESM-2 calibrated P(essential)=0.141; HANSEN integrated essentiality score=0.214; ProteomeLM contextual percentile=0.422; target-priority score=64.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 385 ML1301 P46726 cysQ ML1301 B2126_C3_229 3'-phosphoadenosine 5'-phosphate phosphatase (PAP phosphatase) (EC 3.1.3.7) (3'(2'),5'-bisphosphate nucleotidase) (3'(2'),5-bisphosphonucleoside 3'(2')-phosphohydrolase) (D-fructose-1,6-bisphosphate 1-phosphohydrolase) (DPNPase) (Fructose-1,6-bisphosphatase) (FBPase) (EC 3.1.3.11) (Inositol-1-monophosphatase) (I-1-Pase) (IMPase) (EC 3.1.3.25) (Inositol-1-phosphatase) 271 0.12677 non-essential 0.2143 non-essential high NA medium_confidence NP_216647.1 78.5 0.46399 73.083 Strong candidate ESM-2 calibrated P(essential)=0.127; HANSEN integrated essentiality score=0.214; ProteomeLM contextual percentile=0.464; target-priority score=73.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 386 ML2535 Q9CD30 ML2535 FtsK domain-containing protein 1329 0.0446 non-essential 0.21414 non-essential high NA medium_confidence NP_214798.1 84.2 0.83719 74.065 Strong candidate ESM-2 calibrated P(essential)=0.045; HANSEN integrated essentiality score=0.214; ProteomeLM contextual percentile=0.837; target-priority score=74.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:45Z 387 ML0918 Q9CCE3 ML0918 Purine nucleoside phosphorylase ML0918 (EC 2.4.2.1) (Adenosine deaminase ML0918) (EC 3.5.4.4) (S-methyl-5'-thioadenosine phosphorylase ML0918) (EC 2.4.2.28) 249 0.01761 non-essential 0.2141 non-essential high NA medium_confidence NP_216665.1 60.2 0.92924 84.786 High-priority ESM-2 calibrated P(essential)=0.018; HANSEN integrated essentiality score=0.214; ProteomeLM contextual percentile=0.929; target-priority score=84.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 388 ML0017 P54743 pknA ML0017 Serine/threonine-protein kinase PknA (EC 2.7.11.1) 437 0.07935 non-essential 0.21403 non-essential high NA medium_confidence NP_214529.1 81.0 0.67502 74.784 Strong candidate ESM-2 calibrated P(essential)=0.079; HANSEN integrated essentiality score=0.214; ProteomeLM contextual percentile=0.675; target-priority score=74.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 389 ML1210 Q9CC69 ML1210 Uncharacterized protein 61 0.01709 non-essential 0.21377 non-essential high NA medium_confidence 0.96681 72.177 Strong candidate ESM-2 calibrated P(essential)=0.017; HANSEN integrated essentiality score=0.214; ProteomeLM contextual percentile=0.967; target-priority score=72.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 390 ML0560 Q9CCP3 ribH ML0560 6,7-dimethyl-8-ribityllumazine synthase (DMRL synthase) (LS) (Lumazine synthase) (EC 2.5.1.78) 160 0.09625 non-essential 0.2135 non-essential high NA medium_confidence NP_215932.2 79.1 0.58422 78.228 Strong candidate ESM-2 calibrated P(essential)=0.096; HANSEN integrated essentiality score=0.214; ProteomeLM contextual percentile=0.584; target-priority score=78.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 391 ML0470 Q7AQI7 ML0470 Uncharacterized protein 96 0.01019 non-essential 0.21343 non-essential high NA medium_confidence 0.99812 71.608 Strong candidate ESM-2 calibrated P(essential)=0.010; HANSEN integrated essentiality score=0.213; ProteomeLM contextual percentile=0.998; target-priority score=71.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 392 ML1004 Q7AQB5 ML1004 Possible conserved membrane protein 164 0.04818 non-essential 0.21341 non-essential high NA medium_confidence NP_217235.1 57.0 0.83344 68.294 Strong candidate ESM-2 calibrated P(essential)=0.048; HANSEN integrated essentiality score=0.213; ProteomeLM contextual percentile=0.833; target-priority score=68.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 393 ML0053 Q7AQP0 ML0053 Membrane protein 744 0.06628 non-essential 0.2134 non-essential high NA medium_confidence NP_218387.1 86.1 0.74327 70.693 Strong candidate ESM-2 calibrated P(essential)=0.066; HANSEN integrated essentiality score=0.213; ProteomeLM contextual percentile=0.743; target-priority score=70.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 394 ML2707 Q9CCX7 parA ML2707 Cell division protein 351 0.04459 non-essential 0.21338 non-essential high NA medium_confidence NP_218434.2 86.3 0.83594 72.986 Strong candidate ESM-2 calibrated P(essential)=0.045; HANSEN integrated essentiality score=0.213; ProteomeLM contextual percentile=0.836; target-priority score=73.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 395 ML2329 O69520 recR ML2329 MLCB2407.21 Recombination protein RecR 203 0.19217 non-essential 0.21324 non-essential high NA medium_confidence NP_218232.1 91.6 0.22041 51.753 Moderate candidate ESM-2 calibrated P(essential)=0.192; HANSEN integrated essentiality score=0.213; ProteomeLM contextual percentile=0.220; target-priority score=51.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 396 ML2196 Q9CBC8 thiX ML2196 Thiredoxin 140 0.0533 non-essential 0.2132 non-essential high NA medium_confidence NP_215331.1 63.8 0.79775 72.017 Strong candidate ESM-2 calibrated P(essential)=0.053; HANSEN integrated essentiality score=0.213; ProteomeLM contextual percentile=0.798; target-priority score=72.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 397 ML0938 Q9CCD4 ML0938 Uncharacterized protein 98 0.01709 non-essential 0.21306 non-essential high NA medium_confidence 0.95805 73.719 Strong candidate ESM-2 calibrated P(essential)=0.017; HANSEN integrated essentiality score=0.213; ProteomeLM contextual percentile=0.958; target-priority score=73.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 398 ML1972 Q9CBH6 ML1972 Uncharacterized protein 76 0.0263 non-essential 0.21289 non-essential high NA medium_confidence 0.92235 71.158 Strong candidate ESM-2 calibrated P(essential)=0.026; HANSEN integrated essentiality score=0.213; ProteomeLM contextual percentile=0.922; target-priority score=71.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 399 ML2708 Q50203 rsmG gidB ML2708 Ribosomal RNA small subunit methyltransferase G (EC 2.1.1.-) (16S rRNA 7-methylguanosine methyltransferase) (16S rRNA m7G methyltransferase) (Glucose-inhibited division protein B) 245 0.0499 non-essential 0.21279 non-essential high NA medium_confidence NP_218436.2 68.9 0.78961 79.268 Strong candidate ESM-2 calibrated P(essential)=0.050; HANSEN integrated essentiality score=0.213; ProteomeLM contextual percentile=0.790; target-priority score=79.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 400 ML1666 Q7AQ31 ML1666 Conserved integral membrane protein 214 0.0998 non-essential 0.21268 non-essential high NA medium_confidence NP_217484.1 72.0 0.6005 65.497 Strong candidate ESM-2 calibrated P(essential)=0.100; HANSEN integrated essentiality score=0.213; ProteomeLM contextual percentile=0.601; target-priority score=65.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 401 ML0127 Q9CD89 ML0127 Rhamnosyl O-methyltransferase (EC 2.1.1.-) 229 0.0533 non-essential 0.21235 non-essential high NA medium_confidence NP_217475.1 76.1 0.77708 77.344 Strong candidate ESM-2 calibrated P(essential)=0.053; HANSEN integrated essentiality score=0.212; ProteomeLM contextual percentile=0.777; target-priority score=77.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 402 ML1344 Q9CC35 ML1344 Doubtful CDS 86 0.02368 non-essential 0.21208 non-essential high NA medium_confidence 0.92799 71.691 Strong candidate ESM-2 calibrated P(essential)=0.024; HANSEN integrated essentiality score=0.212; ProteomeLM contextual percentile=0.928; target-priority score=71.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 403 ML1763 Q9CBN9 ML1763 Uncharacterized protein 71 0.01019 non-essential 0.212 non-essential high NA medium_confidence 0.98998 71.519 Strong candidate ESM-2 calibrated P(essential)=0.010; HANSEN integrated essentiality score=0.212; ProteomeLM contextual percentile=0.990; target-priority score=71.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 404 ML2595 Q9CD08 ML2595 Possible membrane protein 182 0.03604 non-essential 0.21192 non-essential high NA medium_confidence NP_214689.3 69.1 0.86913 72.113 Strong candidate ESM-2 calibrated P(essential)=0.036; HANSEN integrated essentiality score=0.212; ProteomeLM contextual percentile=0.869; target-priority score=72.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 405 ML2366 Q7APV5 ML2366 Membrane protein 113 0.04042 non-essential 0.21189 non-essential high NA medium_confidence NP_218277.1 70.2 0.85661 69.48 Strong candidate ESM-2 calibrated P(essential)=0.040; HANSEN integrated essentiality score=0.212; ProteomeLM contextual percentile=0.857; target-priority score=69.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 406 ML0958 Q9CCC6 ML0958 Membrane protein 143 0.01019 non-essential 0.21161 non-essential high NA medium_confidence 0.98622 71.999 Strong candidate ESM-2 calibrated P(essential)=0.010; HANSEN integrated essentiality score=0.212; ProteomeLM contextual percentile=0.986; target-priority score=72.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 407 ML1736 Q9CBP8 nrdH ML1736 Glutaredoxin-like protein NrdH 80 0.09928 non-essential 0.2115 non-essential high NA medium_confidence NP_217569.1 91.1 0.59925 64.387 Moderate candidate ESM-2 calibrated P(essential)=0.099; HANSEN integrated essentiality score=0.212; ProteomeLM contextual percentile=0.599; target-priority score=64.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 408 ML1440 Q7AQ50 ML1440 Bifunctional apolipoprotein N-acyltransferase/polyprenol monophosphomannose synthase (EC 2.3.1.269) (EC 2.4.1.83) 277 0.09148 non-essential 0.21144 non-essential high NA medium_confidence 0.60426 74.712 Strong candidate ESM-2 calibrated P(essential)=0.091; HANSEN integrated essentiality score=0.211; ProteomeLM contextual percentile=0.604; target-priority score=74.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 409 ML0628 Q49752 ybeY ML0628 B1937_F1_21 Endoribonuclease YbeY (EC 3.1.-.-) 178 0.03424 non-essential 0.21138 non-essential high NA medium_confidence NP_216883.1 89.1 0.85034 80.229 High-priority ESM-2 calibrated P(essential)=0.034; HANSEN integrated essentiality score=0.211; ProteomeLM contextual percentile=0.850; target-priority score=80.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 410 ML1188 Q9CC70 ML1188 HTH gntR-type domain-containing protein 86 0.01544 non-essential 0.21126 non-essential high NA medium_confidence 0.95366 74.182 Strong candidate ESM-2 calibrated P(essential)=0.015; HANSEN integrated essentiality score=0.211; ProteomeLM contextual percentile=0.954; target-priority score=74.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 411 ML0839 O32978 cysK ML0839 MLCB22.47 O-acetylserine sulfhydrylase (OAS sulfhydrylase) (OASS) (EC 2.5.1.47) (Cysteine synthase A) (CSase A) (O-acetylserine (thiol)-lyase A) (OAS-TL A) (O-acetylserine-specific cysteine synthase) (Sulfide-dependent cysteine synthase) 310 0.09373 non-essential 0.2112 non-essential high NA medium_confidence YP_177868.1 85.8 0.58359 77.756 Strong candidate ESM-2 calibrated P(essential)=0.094; HANSEN integrated essentiality score=0.211; ProteomeLM contextual percentile=0.584; target-priority score=77.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 412 ML1910 Q9CBJ6 ML1910 UPF0336 protein ML1910 159 0.08446 non-essential 0.21109 non-essential high NA medium_confidence NP_215149.1 85.5 0.66124 65.602 Strong candidate ESM-2 calibrated P(essential)=0.084; HANSEN integrated essentiality score=0.211; ProteomeLM contextual percentile=0.661; target-priority score=65.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 413 ML0052 Q9CDD7 ML0052 FtsK domain-containing protein 597 0.05587 non-essential 0.21078 non-essential high NA medium_confidence NP_218388.1 80.0 0.76581 74.016 Strong candidate ESM-2 calibrated P(essential)=0.056; HANSEN integrated essentiality score=0.211; ProteomeLM contextual percentile=0.766; target-priority score=74.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 414 ML0464 Q9CCT8 ML0464 Uncharacterized protein 95 0.01648 non-essential 0.21075 non-essential high NA medium_confidence 0.95679 70.484 Strong candidate ESM-2 calibrated P(essential)=0.016; HANSEN integrated essentiality score=0.211; ProteomeLM contextual percentile=0.957; target-priority score=70.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 415 ML2614 Q7APT2 ML2614 Conserved membrane protein 224 0.04656 non-essential 0.21066 non-essential high NA medium_confidence NP_214713.1 67.6 0.82091 69.578 Strong candidate ESM-2 calibrated P(essential)=0.047; HANSEN integrated essentiality score=0.211; ProteomeLM contextual percentile=0.821; target-priority score=69.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 416 ML2412 Q9CB61 ML2412 Thioredoxin domain-containing protein 222 0.09148 non-essential 0.21062 non-essential high NA medium_confidence NP_215040.1 78.5 0.62367 66.475 Strong candidate ESM-2 calibrated P(essential)=0.091; HANSEN integrated essentiality score=0.211; ProteomeLM contextual percentile=0.624; target-priority score=66.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 417 ML1477 Q9CBY6 clpX ML1477 ATP-dependent Clp protease ATP-binding subunit ClpX 426 0.23815 non-essential 0.21049 non-essential medium NA medium_confidence NP_216973.1 96.0 0.00438 47.984 Exploratory ESM-2 calibrated P(essential)=0.238; HANSEN integrated essentiality score=0.210; ProteomeLM contextual percentile=0.004; target-priority score=48.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 418 ML2388 Q7APV4 ML2388 Possible membrane protein 101 0.06278 non-essential 0.21046 non-essential high NA medium_confidence NP_214977.1 57.9 0.75391 66.659 Strong candidate ESM-2 calibrated P(essential)=0.063; HANSEN integrated essentiality score=0.210; ProteomeLM contextual percentile=0.754; target-priority score=66.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 419 ML2502 Q9CB19 ML2502 Alanine aminotransferase (EC 2.6.1.2) (Alanine transaminase) (Transaminase A) 437 0.23313 non-essential 0.21029 non-essential medium NA medium_confidence NP_214851.1 91.4 0.0144 52.002 Moderate candidate ESM-2 calibrated P(essential)=0.233; HANSEN integrated essentiality score=0.210; ProteomeLM contextual percentile=0.014; target-priority score=52.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 420 ML0207 Q7AQL8 ML0207 Glycosyltransferase 239 0.13353 non-essential 0.21023 non-essential high NA medium_confidence NP_218148.1 80.2 0.45085 58.865 Moderate candidate ESM-2 calibrated P(essential)=0.134; HANSEN integrated essentiality score=0.210; ProteomeLM contextual percentile=0.451; target-priority score=58.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 421 ML1692 O33116 serA ML1692 MLCB637.25 D-3-phosphoglycerate dehydrogenase (PGDH) (EC 1.1.1.95) (2-oxoglutarate reductase) (EC 1.1.1.399) 528 0.14132 non-essential 0.21019 non-essential high NA medium_confidence YP_177916.1 89.8 0.38071 70.485 Strong candidate ESM-2 calibrated P(essential)=0.141; HANSEN integrated essentiality score=0.210; ProteomeLM contextual percentile=0.381; target-priority score=70.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 422 ML0056 Q9CDD6 ML0056 Uncharacterized protein 169 0.02105 non-essential 0.21018 non-essential high NA medium_confidence 0.93237 70.515 Strong candidate ESM-2 calibrated P(essential)=0.021; HANSEN integrated essentiality score=0.210; ProteomeLM contextual percentile=0.932; target-priority score=70.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 423 ML0139 Q9CD78 mas ML0139 Mycocerosic synthase 2116 0.05604 non-essential 0.21005 non-essential high NA medium_confidence NP_217456.1 88.0 0.76331 73.154 Strong candidate ESM-2 calibrated P(essential)=0.056; HANSEN integrated essentiality score=0.210; ProteomeLM contextual percentile=0.763; target-priority score=73.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:45Z 424 ML2178 Q9CBD0 ML2178 VapC45 PIN like domain-containing protein 83 0.01761 non-essential 0.21 non-essential high NA medium_confidence 0.94678 70.631 Strong candidate ESM-2 calibrated P(essential)=0.018; HANSEN integrated essentiality score=0.210; ProteomeLM contextual percentile=0.947; target-priority score=70.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 425 ML1011 Q9CCB6 ML1011 Uncharacterized protein 140 0.00674 non-essential 0.20999 non-essential high NA medium_confidence 0.99436 71.378 Strong candidate ESM-2 calibrated P(essential)=0.007; HANSEN integrated essentiality score=0.210; ProteomeLM contextual percentile=0.994; target-priority score=71.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 426 ML0232 Q9CD56 coaX ML0232 Type III pantothenate kinase (EC 2.7.1.33) (PanK-III) (Pantothenic acid kinase) 274 0.13088 non-essential 0.20998 non-essential high NA medium_confidence NP_218117.1 90.9 0.42142 72.522 Strong candidate ESM-2 calibrated P(essential)=0.131; HANSEN integrated essentiality score=0.210; ProteomeLM contextual percentile=0.421; target-priority score=72.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 427 ML0869 Q9CCF6 ML0869 MLCB22.07 Uncharacterized protein ML0869 229 0.08883 non-essential 0.20992 non-essential high NA medium_confidence NP_216722.2 67.5 0.63431 65.588 Strong candidate ESM-2 calibrated P(essential)=0.089; HANSEN integrated essentiality score=0.210; ProteomeLM contextual percentile=0.634; target-priority score=65.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 428 ML2696 Q9CCY2 ML2696 MarR-family regulatory protein 243 0.02233 non-essential 0.20987 non-essential high NA medium_confidence NP_214556.1 81.7 0.91421 74.061 Strong candidate ESM-2 calibrated P(essential)=0.022; HANSEN integrated essentiality score=0.210; ProteomeLM contextual percentile=0.914; target-priority score=74.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 429 ML1122 Q9CC81 ML1122 Oligopeptide transport ATP-binding protein OppD (EC 7.4.2.6) 609 0.14132 non-essential 0.2097 non-essential high NA medium_confidence NP_215797.1 84.3 0.39386 65.022 Strong candidate ESM-2 calibrated P(essential)=0.141; HANSEN integrated essentiality score=0.210; ProteomeLM contextual percentile=0.394; target-priority score=65.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 430 ML0029 Q9CDE0 ML0029 Possible membrane protein 201 0.00888 non-essential 0.20967 non-essential high NA medium_confidence 0.97996 72.303 Strong candidate ESM-2 calibrated P(essential)=0.009; HANSEN integrated essentiality score=0.210; ProteomeLM contextual percentile=0.980; target-priority score=72.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 431 ML0630 Q49767 ML0630 Cytidine deaminase 108 0.15503 non-essential 0.20957 non-essential high agree medium_confidence Rv2365c 60.4 NE 0 0.82405 68.29 Strong candidate ESM-2 calibrated P(essential)=0.155; HANSEN integrated essentiality score=0.210; Mtb RBH anchor Rv2365c=non-essential (agree); ProteomeLM contextual percentile=0.824; target-priority score=68.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 432 ML1546 Q9Z5I4 truB ML1546 MLCB596.24 tRNA pseudouridine synthase B (EC 5.4.99.25) (tRNA pseudouridine(55) synthase) (Psi55 synthase) (tRNA pseudouridylate synthase) (tRNA-uridine isomerase) 320 0.06042 non-essential 0.20952 non-essential high NA medium_confidence NP_217309.1 74.1 0.72386 78.672 Strong candidate ESM-2 calibrated P(essential)=0.060; HANSEN integrated essentiality score=0.210; ProteomeLM contextual percentile=0.724; target-priority score=78.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 433 ML1387 P57991 uvrB ML1387 UvrABC system protein B (Protein UvrB) (Excinuclease ABC subunit B) 698 0.23815 non-essential 0.20942 non-essential medium NA medium_confidence NP_216149.3 94.8 0.00376 46.041 Exploratory ESM-2 calibrated P(essential)=0.238; HANSEN integrated essentiality score=0.209; ProteomeLM contextual percentile=0.004; target-priority score=46.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 434 ML1010 Q9CCB7 ML1010 Uncharacterized protein 80 0.02224 non-essential 0.20936 non-essential high NA medium_confidence 0.92549 69.367 Strong candidate ESM-2 calibrated P(essential)=0.022; HANSEN integrated essentiality score=0.209; ProteomeLM contextual percentile=0.925; target-priority score=69.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 435 ML0117 Q9CD97 ML0117 Aminotransferase class V domain-containing protein 398 0.17976 non-essential 0.20926 non-essential high NA medium_confidence NP_218295.1 83.4 0.24984 53.152 Moderate candidate ESM-2 calibrated P(essential)=0.180; HANSEN integrated essentiality score=0.209; ProteomeLM contextual percentile=0.250; target-priority score=53.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 436 ML0175 Q9Z5G7 mprB ML0175 MLCB373.27 Signal transduction histidine-protein kinase/phosphatase MprB (EC 2.7.13.3) (EC 3.1.3.-) (Mycobacterial persistence regulator B) 519 0.08711 non-essential 0.20918 non-essential high NA medium_confidence NP_215497.1 81.3 0.62242 70.845 Strong candidate ESM-2 calibrated P(essential)=0.087; HANSEN integrated essentiality score=0.209; ProteomeLM contextual percentile=0.622; target-priority score=70.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 437 ML1191 Q7AQ85 fas ML1191 Fatty acid synthase 3076 0.12712 non-essential 0.20915 non-essential high NA medium_confidence NP_217040.1 85.2 0.5 ESM-2 calibrated P(essential)=0.127; HANSEN integrated essentiality score=0.209; ProteomeLM contextual percentile=0.500 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:45Z 438 ML0961 O05564 metE ML0961 MLCB33.14 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase (EC 2.1.1.14) (Cobalamin-independent methionine synthase) (Methionine synthase, vitamin-B12 independent isozyme) 760 0.14132 non-essential 0.20912 non-essential high NA medium_confidence NP_215649.1 85.0 0.37696 69.616 Strong candidate ESM-2 calibrated P(essential)=0.141; HANSEN integrated essentiality score=0.209; ProteomeLM contextual percentile=0.377; target-priority score=69.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 439 ML1408 Q9CC13 argB ML1408 Acetylglutamate kinase (EC 2.7.2.8) (N-acetyl-L-glutamate 5-phosphotransferase) (NAG kinase) (NAGK) 297 0.18715 non-essential 0.20908 non-essential high NA medium_confidence NP_216170.1 87.5 0.18472 63.397 Moderate candidate ESM-2 calibrated P(essential)=0.187; HANSEN integrated essentiality score=0.209; ProteomeLM contextual percentile=0.185; target-priority score=63.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 440 ML0861 Q7AQE7 ML0861 Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex (EC 2.3.1.-) 530 0.1084 non-essential 0.20902 non-essential high NA medium_confidence NP_216731.1 77.8 0.53225 67.96 Strong candidate ESM-2 calibrated P(essential)=0.108; HANSEN integrated essentiality score=0.209; ProteomeLM contextual percentile=0.532; target-priority score=68.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 441 ML1209 Q9X7F1 ilvA ML1209 L-threonine dehydratase biosynthetic IlvA (EC 4.3.1.19) (Threonine deaminase) 427 0.14132 non-essential 0.20895 non-essential high NA medium_confidence NP_216075.1 87.4 0.37508 69.921 Strong candidate ESM-2 calibrated P(essential)=0.141; HANSEN integrated essentiality score=0.209; ProteomeLM contextual percentile=0.375; target-priority score=69.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 442 ML0239 Q9CD54 ML0239 Uncharacterized protein 262 0.05422 non-essential 0.20888 non-essential high NA medium_confidence NP_215524.1 82.7 0.75892 75.133 Strong candidate ESM-2 calibrated P(essential)=0.054; HANSEN integrated essentiality score=0.209; ProteomeLM contextual percentile=0.759; target-priority score=75.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 443 ML1270 Q9CC55 ML1270 Possible conserved membrane protein 265 0.03424 non-essential 0.20862 non-essential high NA medium_confidence NP_216126.1 64.1 0.86287 70.459 Strong candidate ESM-2 calibrated P(essential)=0.034; HANSEN integrated essentiality score=0.209; ProteomeLM contextual percentile=0.863; target-priority score=70.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 444 ML1043 P46809 hemE ML1043 Uroporphyrinogen decarboxylase (UPD) (URO-D) (EC 4.1.1.37) 357 0.06199 non-essential 0.2084 non-essential high NA medium_confidence NP_217194.1 83.8 0.70069 81.867 High-priority ESM-2 calibrated P(essential)=0.062; HANSEN integrated essentiality score=0.208; ProteomeLM contextual percentile=0.701; target-priority score=81.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 445 ML1186 Q9CC71 ML1186 Uncharacterized protein 100 0.01005 non-essential 0.20823 non-essential high NA medium_confidence 0.97245 70.138 Strong candidate ESM-2 calibrated P(essential)=0.010; HANSEN integrated essentiality score=0.208; ProteomeLM contextual percentile=0.972; target-priority score=70.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 446 ML1708 Q9CBR5 ML1708 cysteine desulfurase (EC 2.8.1.7) 410 0.11765 non-essential 0.20812 non-essential high NA medium_confidence NP_217541.1 84.9 0.48403 68.125 Strong candidate ESM-2 calibrated P(essential)=0.118; HANSEN integrated essentiality score=0.208; ProteomeLM contextual percentile=0.484; target-priority score=68.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 447 ML2636 Q9CCZ6 pntAA ML2636 NAD(P) transhydrogenase subunit alpha part 1 (EC 7.1.1.1) (Nicotinamide nucleotide transhydrogenase subunit alpha 1) (Pyridine nucleotide transhydrogenase subunit alpha 1) 367 0.13959 non-essential 0.20806 non-essential high NA medium_confidence NP_214669.1 88.7 0.38948 65.924 Strong candidate ESM-2 calibrated P(essential)=0.140; HANSEN integrated essentiality score=0.208; ProteomeLM contextual percentile=0.389; target-priority score=65.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 448 ML0964 Q9CCC3 ML0964 Uncharacterized protein 85 0.01019 non-essential 0.20796 non-essential high NA medium_confidence 0.96869 70.665 Strong candidate ESM-2 calibrated P(essential)=0.010; HANSEN integrated essentiality score=0.208; ProteomeLM contextual percentile=0.969; target-priority score=70.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 449 ML0130 Q9CD86 ML0130 Phthiotriol/phenolphthiotriol dimycocerosates methyltransferase (EC 2.1.1.-) 270 0.06214 non-essential 0.20787 non-essential high NA medium_confidence NP_217468.1 83.7 0.7201 73.952 Strong candidate ESM-2 calibrated P(essential)=0.062; HANSEN integrated essentiality score=0.208; ProteomeLM contextual percentile=0.720; target-priority score=74.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 450 ML2414 P46716 hemL gsa ML2414 B2168_C1_190 Glutamate-1-semialdehyde 2,1-aminomutase (GSA) (EC 5.4.3.8) (Glutamate-1-semialdehyde aminotransferase) (GSA-AT) 446 0.06543 non-essential 0.20774 non-essential high NA medium_confidence NP_215038.1 82.6 0.69067 78.582 Strong candidate ESM-2 calibrated P(essential)=0.065; HANSEN integrated essentiality score=0.208; ProteomeLM contextual percentile=0.691; target-priority score=78.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 451 ML2257 Q9CBB8 menE ML2257 O-succinylbenzoic acid-CoA ligase 368 0.09378 non-essential 0.2077 non-essential high NA medium_confidence NP_215056.1 78.3 0.59612 66.42 Strong candidate ESM-2 calibrated P(essential)=0.094; HANSEN integrated essentiality score=0.208; ProteomeLM contextual percentile=0.596; target-priority score=66.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 452 ML2158 Q9CBD9 ML2158 Uncharacterized protein 130 0.00543 non-essential 0.20762 non-essential high NA medium_confidence 0.98309 72.521 Strong candidate ESM-2 calibrated P(essential)=0.005; HANSEN integrated essentiality score=0.208; ProteomeLM contextual percentile=0.983; target-priority score=72.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 453 ML1671 O69460 recG ML1671 MLCB1243.01 ATP-dependent DNA helicase RecG (EC 5.6.2.4) (DNA branch migration protein RecG) (Probable DNA 3'-5' helicase RecG) 743 0.16853 non-essential 0.20737 non-essential high NA medium_confidence NP_217489.1 79.4 0.26487 61.774 Moderate candidate ESM-2 calibrated P(essential)=0.169; HANSEN integrated essentiality score=0.207; ProteomeLM contextual percentile=0.265; target-priority score=61.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 454 ML2651 Q9CCZ1 ML2651 Doubtful CDS 105 0.01806 non-essential 0.20722 non-essential high NA medium_confidence 0.933 69.047 Strong candidate ESM-2 calibrated P(essential)=0.018; HANSEN integrated essentiality score=0.207; ProteomeLM contextual percentile=0.933; target-priority score=69.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 455 ML0717 Q9CCL4 ML0717 TetR-family transcriptional regulator 223 0.09148 non-essential 0.20715 non-essential high NA medium_confidence NP_217812.1 85.5 0.60551 65.703 Strong candidate ESM-2 calibrated P(essential)=0.091; HANSEN integrated essentiality score=0.207; ProteomeLM contextual percentile=0.606; target-priority score=65.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 456 ML1076 Q9CCA6 sigE ML1076 ECF subfamily sigma subunit 263 0.06638 non-essential 0.20694 non-essential high NA medium_confidence NP_215737.1 83.1 0.71572 66.982 Strong candidate ESM-2 calibrated P(essential)=0.066; HANSEN integrated essentiality score=0.207; ProteomeLM contextual percentile=0.716; target-priority score=67.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 457 ML1653 Q7AQ33 fabD ML1653 Malonyl CoA-acyl carrier protein transacylase (EC 2.3.1.39) 304 0.09148 non-essential 0.20687 non-essential high NA medium_confidence NP_216759.1 82.2 0.5717 76.649 Strong candidate ESM-2 calibrated P(essential)=0.091; HANSEN integrated essentiality score=0.207; ProteomeLM contextual percentile=0.572; target-priority score=76.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 458 ML1523 Q9CBV9 ML1523 Transmembrane protein 96 0.01861 non-essential 0.20668 non-essential high NA medium_confidence 0.92423 70.082 Strong candidate ESM-2 calibrated P(essential)=0.019; HANSEN integrated essentiality score=0.207; ProteomeLM contextual percentile=0.924; target-priority score=70.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 459 ML1581 Q9CBU5 ispG gcpE ML1581 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (flavodoxin) (EC 1.17.7.3) (1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase) 392 0.14132 non-essential 0.20667 non-essential high NA medium_confidence NP_217384.1 87.2 0.36193 69.825 Strong candidate ESM-2 calibrated P(essential)=0.141; HANSEN integrated essentiality score=0.207; ProteomeLM contextual percentile=0.362; target-priority score=69.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 460 ML1248 Q7AQ80 ettA ML1248 Energy-dependent translational throttle protein EttA (EC 3.6.1.-) (Translational regulatory factor EttA) 556 0.20559 non-essential 0.20659 non-essential medium NA medium_confidence NP_216993.1 92.3 0.09894 58.823 Moderate candidate ESM-2 calibrated P(essential)=0.206; HANSEN integrated essentiality score=0.207; ProteomeLM contextual percentile=0.099; target-priority score=58.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 461 ML1537 Q9CBV4 ML1537 Possible secreted protein 401 0.12556 non-essential 0.20651 non-essential high NA medium_confidence NP_216313.1 67.7 0.46462 59.167 Moderate candidate ESM-2 calibrated P(essential)=0.126; HANSEN integrated essentiality score=0.207; ProteomeLM contextual percentile=0.465; target-priority score=59.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 462 ML1923 Q9CBI7 lpqF ML1923 Probale secreted protein 454 0.09148 non-essential 0.20651 non-essential high NA medium_confidence NP_218110.1 79.2 0.60363 65.063 Strong candidate ESM-2 calibrated P(essential)=0.091; HANSEN integrated essentiality score=0.207; ProteomeLM contextual percentile=0.604; target-priority score=65.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 463 ML2468 Q9CB35 ML2468 Uncharacterized protein 126 0.01258 non-essential 0.20634 non-essential high NA medium_confidence 0.94991 70.077 Strong candidate ESM-2 calibrated P(essential)=0.013; HANSEN integrated essentiality score=0.206; ProteomeLM contextual percentile=0.950; target-priority score=70.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 464 ML0837 Q9CCG0 ML0837 Class II aldolase/adducin N-terminal domain-containing protein 127 0.03157 non-essential 0.2062 non-essential high NA medium_confidence 0.85786 71.471 Strong candidate ESM-2 calibrated P(essential)=0.032; HANSEN integrated essentiality score=0.206; ProteomeLM contextual percentile=0.858; target-priority score=71.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 465 ML0394 Q9CCV0 ML0394 Methyltransferase domain-containing protein 170 0.00674 non-essential 0.206 non-essential high NA medium_confidence 0.95992 75.107 Strong candidate ESM-2 calibrated P(essential)=0.007; HANSEN integrated essentiality score=0.206; ProteomeLM contextual percentile=0.960; target-priority score=75.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 466 ML2063 Q7APZ8 ML2063 Transcriptional regulator BlaI 142 0.03604 non-essential 0.20578 non-essential high NA medium_confidence NP_216362.1 95.1 0.82968 73.249 Strong candidate ESM-2 calibrated P(essential)=0.036; HANSEN integrated essentiality score=0.206; ProteomeLM contextual percentile=0.830; target-priority score=73.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 467 ML1417 Q9CC08 cdh ML1417 Probable CDP-diacylglycerol pyrophosphatase (EC 3.6.1.26) (CDP-diacylglycerol phosphatidylhydrolase) (CDP-diglyceride hydrolase) 268 0.02975 non-essential 0.20578 non-essential high NA medium_confidence NP_216805.1 66.4 0.8278 83.702 High-priority ESM-2 calibrated P(essential)=0.030; HANSEN integrated essentiality score=0.206; ProteomeLM contextual percentile=0.828; target-priority score=83.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 468 ML0291 Q7AQK1 ML0291 Uncharacterized protein 130 0.00307 non-essential 0.20562 non-essential high NA medium_confidence 0.98435 71.762 Strong candidate ESM-2 calibrated P(essential)=0.003; HANSEN integrated essentiality score=0.206; ProteomeLM contextual percentile=0.984; target-priority score=71.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 469 ML1605 Q9CBT6 ML1605 Uncharacterized protein 66 0.01233 non-essential 0.20525 non-essential high NA medium_confidence 0.94552 69.789 Strong candidate ESM-2 calibrated P(essential)=0.012; HANSEN integrated essentiality score=0.205; ProteomeLM contextual percentile=0.946; target-priority score=69.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 470 ML0054 Q7AQN9 ML0054 Membrane protein 481 0.10695 non-essential 0.20507 non-essential high NA medium_confidence NP_218386.1 75.6 0.52912 63.387 Moderate candidate ESM-2 calibrated P(essential)=0.107; HANSEN integrated essentiality score=0.205; ProteomeLM contextual percentile=0.529; target-priority score=63.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 471 ML1166 P53424 aosR ML1166 B1549_C3_236 Putative oxidative stress regulator AosR 217 0.03604 non-essential 0.20503 non-essential high NA medium_confidence NP_215848.1 75.1 0.83031 71.539 Strong candidate ESM-2 calibrated P(essential)=0.036; HANSEN integrated essentiality score=0.205; ProteomeLM contextual percentile=0.830; target-priority score=71.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 472 ML0568 Q9CCN7 ML0568 Uncharacterized protein 197 0.02173 non-essential 0.2049 non-essential high NA medium_confidence 0.90357 68.683 Strong candidate ESM-2 calibrated P(essential)=0.022; HANSEN integrated essentiality score=0.205; ProteomeLM contextual percentile=0.904; target-priority score=68.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 473 ML0121 Q9CD93 ML0121 GXWXG domain-containing protein 89 0.00198 non-essential 0.20481 non-essential high NA medium_confidence 0.98685 70.994 Strong candidate ESM-2 calibrated P(essential)=0.002; HANSEN integrated essentiality score=0.205; ProteomeLM contextual percentile=0.987; target-priority score=71.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 474 ML0614 Q49760 ML0614 B1937_F2_47 Uncharacterized protein ML0614 95 0.02414 non-essential 0.20465 non-essential high NA medium_confidence YP_177670.1 66.2 0.88478 70.82 Strong candidate ESM-2 calibrated P(essential)=0.024; HANSEN integrated essentiality score=0.205; ProteomeLM contextual percentile=0.885; target-priority score=70.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 475 ML0527 Q9CCR6 ML0527 Uncharacterized protein 84 0.00543 non-essential 0.20447 non-essential high NA medium_confidence 0.96932 70.903 Strong candidate ESM-2 calibrated P(essential)=0.005; HANSEN integrated essentiality score=0.204; ProteomeLM contextual percentile=0.969; target-priority score=70.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 476 ML1393 Q9CC23 lysX ML1393 Lysylphosphatidylglycerol biosynthesis bifunctional protein LysX [Includes: Lysine--tRNA ligase (EC 6.1.1.6) (Lysyl-tRNA synthetase) (LysRS); Phosphatidylglycerol lysyltransferase (EC 2.3.2.3) (Lysylphosphatidylglycerol synthetase) (LPG synthetase)] 1133 0.02734 non-essential 0.20444 non-essential high NA medium_confidence NP_216156.1 81.6 0.83406 82.639 High-priority ESM-2 calibrated P(essential)=0.027; HANSEN integrated essentiality score=0.204; ProteomeLM contextual percentile=0.834; target-priority score=82.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:45Z 477 ML1783 Q9CBN3 ML1783 Transcriptional regulator 322 0.01364 non-essential 0.20444 non-essential high NA medium_confidence NP_216774.1 65.2 0.91985 74.852 Strong candidate ESM-2 calibrated P(essential)=0.014; HANSEN integrated essentiality score=0.204; ProteomeLM contextual percentile=0.920; target-priority score=74.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 478 ML0950 Q9CCD0 ML0950 Uncharacterized protein 66 0.00301 non-essential 0.20435 non-essential high NA medium_confidence 0.97746 71.684 Strong candidate ESM-2 calibrated P(essential)=0.003; HANSEN integrated essentiality score=0.204; ProteomeLM contextual percentile=0.977; target-priority score=71.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 479 ML2022 Q9CBF9 ML2022 Uncharacterized protein 174 0.00543 non-essential 0.20423 non-essential high NA medium_confidence Rv1893 62.7 UNCERTAIN 0.96619 71.485 Strong candidate ESM-2 calibrated P(essential)=0.005; HANSEN integrated essentiality score=0.204; ProteomeLM contextual percentile=0.966; target-priority score=71.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 480 ML0799 Q9CCI0 ML0799 YbaK/aminoacyl-tRNA synthetase-associated domain-containing protein 135 0.00543 non-essential 0.20402 non-essential high NA medium_confidence 0.94865 77.027 Strong candidate ESM-2 calibrated P(essential)=0.005; HANSEN integrated essentiality score=0.204; ProteomeLM contextual percentile=0.949; target-priority score=77.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 481 ML1069 Q9CCA8 glgC ML1069 Glucose-1-phosphate adenylyltransferase (EC 2.7.7.27) (ADP-glucose pyrophosphorylase) (ADPGlc PPase) (ADP-glucose synthase) 404 0.14132 non-essential 0.20397 non-essential high NA medium_confidence NP_215729.1 90.8 0.34815 69.103 Strong candidate ESM-2 calibrated P(essential)=0.141; HANSEN integrated essentiality score=0.204; ProteomeLM contextual percentile=0.348; target-priority score=69.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 482 ML0620 Q49771 mtb12 ML0620 B1937_F3_91 Low molecular weight antigen MTB12 homolog 167 0.03604 non-essential 0.20394 non-essential high NA medium_confidence NP_216892.1 65.5 0.82655 70.633 Strong candidate ESM-2 calibrated P(essential)=0.036; HANSEN integrated essentiality score=0.204; ProteomeLM contextual percentile=0.827; target-priority score=70.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 483 ML2659 Q9CCY9 ML2659 Probable secreted serine protease 354 0.04897 non-essential 0.20389 non-essential high NA medium_confidence NP_214639.1 65.9 0.76456 71.438 Strong candidate ESM-2 calibrated P(essential)=0.049; HANSEN integrated essentiality score=0.204; ProteomeLM contextual percentile=0.765; target-priority score=71.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 484 ML2584 O69492 ML2584 MLCB1883.02c Uncharacterized methyltransferase ML2584 (EC 2.1.1.-) 269 0.06199 non-essential 0.20387 non-essential high NA medium_confidence NP_214738.1 82.9 0.70006 73.027 Strong candidate ESM-2 calibrated P(essential)=0.062; HANSEN integrated essentiality score=0.204; ProteomeLM contextual percentile=0.700; target-priority score=73.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 485 ML1688 O33120 gltX gltS ML1688 MLCB637.29 Glutamate--tRNA ligase (EC 6.1.1.17) (Glutamyl-tRNA synthetase) (GluRS) 502 0.09148 non-essential 0.20366 non-essential high NA medium_confidence YP_177915.1 82.0 0.55729 75.132 Strong candidate ESM-2 calibrated P(essential)=0.091; HANSEN integrated essentiality score=0.204; ProteomeLM contextual percentile=0.557; target-priority score=75.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 486 ML0874 Q9CCF2 asnB ML0874 asparagine synthase (glutamine-hydrolyzing) (EC 6.3.5.4) 677 0.07471 non-essential 0.20365 non-essential high NA medium_confidence NP_216717.1 83.3 0.6243 78.487 Strong candidate ESM-2 calibrated P(essential)=0.075; HANSEN integrated essentiality score=0.204; ProteomeLM contextual percentile=0.624; target-priority score=78.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 487 ML1137 P45830 wecA rfe ML1137 Decaprenyl-phosphate N-acetylglucosaminephosphotransferase (EC 2.7.8.35) (Decaprenyl-phosphate GlcNAc-1-phosphate transferase) (Decaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphate transferase) (UDP-GlcNAc:decaprenyl-phosphate GlcNAc-1-phosphate transferase) (UDP-N-acetylglucosamine--decaprenyl-phosphate N-acetylglucosaminephosphotransferase) 398 0.0949 non-essential 0.20364 non-essential high NA medium_confidence NP_215818.1 89.4 0.54602 73.589 Strong candidate ESM-2 calibrated P(essential)=0.095; HANSEN integrated essentiality score=0.204; ProteomeLM contextual percentile=0.546; target-priority score=73.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 488 ML1023 Q49988 ppgK ML1023 u1764fg Polyphosphate glucokinase (EC 2.7.1.63) (ATP-dependent glucokinase) (EC 2.7.1.2) (Polyphosphate--glucose phosphotransferase) 324 0.0245 non-essential 0.20364 non-essential high NA medium_confidence NP_217218.1 83.7 0.84471 81.858 High-priority ESM-2 calibrated P(essential)=0.025; HANSEN integrated essentiality score=0.204; ProteomeLM contextual percentile=0.845; target-priority score=81.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 489 ML0156 Q7AQN6 sucD ML0156 Succinate--CoA ligase [ADP-forming] subunit alpha (EC 6.2.1.5) (Succinyl-CoA synthetase subunit alpha) (SCS-alpha) 300 0.1873 non-essential 0.20363 non-essential high NA medium_confidence NP_215467.1 86.3 0.15466 62.488 Moderate candidate ESM-2 calibrated P(essential)=0.187; HANSEN integrated essentiality score=0.204; ProteomeLM contextual percentile=0.155; target-priority score=62.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 490 ML0570 P46713 gapA gap ML0570 B1496_C3_199 Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) (EC 1.2.1.12) (NAD-dependent glyceraldehyde-3-phosphate dehydrogenase) 339 0.09638 non-essential 0.20339 non-essential high NA medium_confidence NP_215952.1 89.4 0.52849 76.739 Strong candidate ESM-2 calibrated P(essential)=0.096; HANSEN integrated essentiality score=0.203; ProteomeLM contextual percentile=0.528; target-priority score=76.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 491 ML1989 Q9CBG7 ML1989 Uncharacterized protein 116 0.00543 non-essential 0.20334 non-essential high NA medium_confidence 0.96243 70.989 Strong candidate ESM-2 calibrated P(essential)=0.005; HANSEN integrated essentiality score=0.203; ProteomeLM contextual percentile=0.962; target-priority score=71.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 492 ML2618 Q9CD01 ML2618 Probable integral membrane protein 352 0.02837 non-essential 0.20328 non-essential high NA medium_confidence NP_214718.2 84.5 0.85285 72.337 Strong candidate ESM-2 calibrated P(essential)=0.028; HANSEN integrated essentiality score=0.203; ProteomeLM contextual percentile=0.853; target-priority score=72.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 493 ML2603 Q9CD03 ML2603 Monoacylglycerol lipase (EC 3.1.1.23) 279 0.18438 non-essential 0.20326 non-essential high NA medium_confidence NP_214697.2 74.9 0.17721 58.644 Moderate candidate ESM-2 calibrated P(essential)=0.184; HANSEN integrated essentiality score=0.203; ProteomeLM contextual percentile=0.177; target-priority score=58.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 494 ML0398 Q49738 ML0398 D-ribose-binding protein 345 0.06441 non-essential 0.20299 non-essential high NA medium_confidence 0.69756 68.326 Strong candidate ESM-2 calibrated P(essential)=0.064; HANSEN integrated essentiality score=0.203; ProteomeLM contextual percentile=0.698; target-priority score=68.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 495 ML0576 Q7AQI3 ML0576 Uncharacterized protein 76 0.01364 non-essential 0.20285 non-essential high NA medium_confidence 0.92361 70.407 Strong candidate ESM-2 calibrated P(essential)=0.014; HANSEN integrated essentiality score=0.203; ProteomeLM contextual percentile=0.924; target-priority score=70.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 496 ML0369 Q49877 ML0369 Uncharacterized protein 118 0.00543 non-essential 0.20284 non-essential high NA medium_confidence 0.95742 71.695 Strong candidate ESM-2 calibrated P(essential)=0.005; HANSEN integrated essentiality score=0.203; ProteomeLM contextual percentile=0.957; target-priority score=71.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 497 ML0808 Q9CCH5 entC ML0808 isochorismate synthase (EC 5.4.4.2) (Isochorismate mutase) 577 0.00543 non-essential 0.20275 non-essential high NA medium_confidence NP_217731.1 74.0 0.92674 81.949 High-priority ESM-2 calibrated P(essential)=0.005; HANSEN integrated essentiality score=0.203; ProteomeLM contextual percentile=0.927; target-priority score=81.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 498 ML0523 Q9CCR9 nusB ML0523 Transcription antitermination protein NusB (Antitermination factor NusB) 190 0.05857 non-essential 0.20262 non-essential high NA medium_confidence NP_217049.1 75.7 0.71947 69.249 Strong candidate ESM-2 calibrated P(essential)=0.059; HANSEN integrated essentiality score=0.203; ProteomeLM contextual percentile=0.719; target-priority score=69.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 499 ML2098 Q50103 mntH bcg ML2098 Divalent metal cation transporter MntH 426 0.03453 non-essential 0.2026 non-essential high NA medium_confidence YP_177767.1 74.6 0.81966 72.648 Strong candidate ESM-2 calibrated P(essential)=0.035; HANSEN integrated essentiality score=0.203; ProteomeLM contextual percentile=0.820; target-priority score=72.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 500 ML1622 O33013 ffh ML1622 MLCB250.20 Signal recognition particle protein (EC 3.6.5.4) (Fifty-four homolog) 521 0.12534 non-essential 0.20259 non-essential high NA medium_confidence NP_217432.1 84.7 0.41891 67.215 Strong candidate ESM-2 calibrated P(essential)=0.125; HANSEN integrated essentiality score=0.203; ProteomeLM contextual percentile=0.419; target-priority score=67.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 501 ML1114 Q9CC88 ML1114 Probable ABC transporter protein, ATP-binding component 584 0.09677 non-essential 0.20259 non-essential high NA medium_confidence NP_215789.1 77.8 0.56356 62.61 Moderate candidate ESM-2 calibrated P(essential)=0.097; HANSEN integrated essentiality score=0.203; ProteomeLM contextual percentile=0.564; target-priority score=62.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 502 ML2490 Q9CB26 clpB ML2490 Chaperone protein ClpB 848 0.13353 non-essential 0.20257 non-essential high NA medium_confidence NP_214898.1 89.2 0.40576 58.871 Moderate candidate ESM-2 calibrated P(essential)=0.134; HANSEN integrated essentiality score=0.203; ProteomeLM contextual percentile=0.406; target-priority score=58.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:45Z 503 ML1142 P53006 atpFH atpF atpH ML1142 ATP synthase subunit b-delta [Includes: ATP synthase subunit b (ATP synthase F(0) sector subunit b 2) (ATPase subunit I 2) (F-type ATPase subunit b 2) (F-ATPase subunit b 2); ATP synthase subunit delta (ATP synthase F(1) sector subunit delta) (F-type ATPase subunit delta) (F-ATPase subunit delta)] 446 0.14132 non-essential 0.20235 non-essential high NA medium_confidence NP_215823.1 71.7 0.37257 57.571 Moderate candidate ESM-2 calibrated P(essential)=0.141; HANSEN integrated essentiality score=0.202; ProteomeLM contextual percentile=0.373; target-priority score=57.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 504 ML1328 P54077 pafA ML1328 B2126_C2_219 MLCB2533.24 Pup--protein ligase (EC 6.3.1.19) (Proteasome accessory factor A) (Pup-conjugating enzyme) 452 0.03786 non-essential 0.20234 non-essential high NA medium_confidence NP_216613.1 95.1 0.76706 84.816 High-priority ESM-2 calibrated P(essential)=0.038; HANSEN integrated essentiality score=0.202; ProteomeLM contextual percentile=0.767; target-priority score=84.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 505 ML2130 Q7APY8 gltA2 ML2130 Citrate synthase 431 0.14132 non-essential 0.20214 non-essential high NA medium_confidence NP_215411.1 91.2 0.3469 65.877 Strong candidate ESM-2 calibrated P(essential)=0.141; HANSEN integrated essentiality score=0.202; ProteomeLM contextual percentile=0.347; target-priority score=65.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 506 ML0155 Q9Z5H8 sucC ML0155 MLCB373.03 Succinate--CoA ligase [ADP-forming] subunit beta (EC 6.2.1.5) (Succinyl-CoA synthetase subunit beta) (SCS-beta) 393 0.13529 non-essential 0.20201 non-essential high NA medium_confidence NP_215466.1 86.7 0.36443 69.064 Strong candidate ESM-2 calibrated P(essential)=0.135; HANSEN integrated essentiality score=0.202; ProteomeLM contextual percentile=0.364; target-priority score=69.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 507 ML1807 Q9CBM0 fabG1 ML1807 3-oxoacyl-[ACP] reductase (Aka MabA) 253 0.07126 non-essential 0.20196 non-essential high NA medium_confidence NP_215999.1 69.7 0.65623 69.627 Strong candidate ESM-2 calibrated P(essential)=0.071; HANSEN integrated essentiality score=0.202; ProteomeLM contextual percentile=0.656; target-priority score=69.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 508 ML1584 Q9CBU2 ML1584 Uncharacterized protein ML1584 84 0.04792 non-essential 0.20185 non-essential high NA medium_confidence NP_217392.1 73.9 0.77082 66.859 Strong candidate ESM-2 calibrated P(essential)=0.048; HANSEN integrated essentiality score=0.202; ProteomeLM contextual percentile=0.771; target-priority score=66.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 509 ML0153 Q9CD72 uvrD ML0153 ATP-dependent DNA helicase UvrD1 (EC 5.6.2.4) (DNA 3'-5' helicase UvrD1) 778 0.19217 non-essential 0.20168 non-essential high NA medium_confidence YP_177772.1 81.4 0.13776 56.733 Moderate candidate ESM-2 calibrated P(essential)=0.192; HANSEN integrated essentiality score=0.202; ProteomeLM contextual percentile=0.138; target-priority score=56.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:45Z 510 ML0841 P46841 enc mmpI ML0841 MLCB22.45c Type 2A encapsulin shell protein (35 kDa antigen) (Major membrane protein I) (MMPI) 307 0.08245 non-essential 0.20168 non-essential high NA medium_confidence 0.6149 65.681 Strong candidate ESM-2 calibrated P(essential)=0.082; HANSEN integrated essentiality score=0.202; ProteomeLM contextual percentile=0.615; target-priority score=65.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 511 ML2598 Q9CD05 ML2598 Secreted protein 184 0.07168 non-essential 0.20155 non-essential high NA medium_confidence NP_214692.1 77.9 0.66187 66.249 Strong candidate ESM-2 calibrated P(essential)=0.072; HANSEN integrated essentiality score=0.202; ProteomeLM contextual percentile=0.662; target-priority score=66.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 512 ML1148 Q7AQ91 ML1148 Doubtful CDS 51 0.00674 non-essential 0.20143 non-essential high NA medium_confidence 0.94302 71.713 Strong candidate ESM-2 calibrated P(essential)=0.007; HANSEN integrated essentiality score=0.201; ProteomeLM contextual percentile=0.943; target-priority score=71.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 513 ML1572 Q9CBV0 ML1572 PglZ domain-containing protein 132 0.00198 non-essential 0.20138 non-essential high NA medium_confidence 0.95867 73.729 Strong candidate ESM-2 calibrated P(essential)=0.002; HANSEN integrated essentiality score=0.201; ProteomeLM contextual percentile=0.959; target-priority score=73.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 514 ML1810 Q9CBL7 moxR ML1810 MoxR homolog 377 0.12139 non-essential 0.20136 non-essential high NA medium_confidence YP_177816.1 90.2 0.45335 59.215 Moderate candidate ESM-2 calibrated P(essential)=0.121; HANSEN integrated essentiality score=0.201; ProteomeLM contextual percentile=0.453; target-priority score=59.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 515 ML0678 Q7AQG2 ML0678 Transposase IS116/IS110/IS902 C-terminal domain-containing protein 175 0.0 non-essential 0.20121 non-essential high NA medium_confidence 0.96431 74.552 Strong candidate ESM-2 calibrated P(essential)=0.000; HANSEN integrated essentiality score=0.201; ProteomeLM contextual percentile=0.964; target-priority score=74.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 516 ML0679 Q9CCM3 ML0679 Uncharacterized protein 75 0.00674 non-essential 0.20109 non-essential high NA medium_confidence 0.9474 69.539 Strong candidate ESM-2 calibrated P(essential)=0.007; HANSEN integrated essentiality score=0.201; ProteomeLM contextual percentile=0.947; target-priority score=69.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 517 ML2253 Q7APW9 ML2253 Antigen 84 homolog 71 0.00674 non-essential 0.20091 non-essential high NA medium_confidence 0.93926 71.958 Strong candidate ESM-2 calibrated P(essential)=0.007; HANSEN integrated essentiality score=0.201; ProteomeLM contextual percentile=0.939; target-priority score=72.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 518 ML0751 Q9CCK8 rmlD ML0751 dTDP-4-dehydrorhamnose reductase (EC 1.1.1.133) 311 0.03424 non-essential 0.20066 non-essential high NA medium_confidence NP_217783.1 74.0 0.78835 79.858 Strong candidate ESM-2 calibrated P(essential)=0.034; HANSEN integrated essentiality score=0.201; ProteomeLM contextual percentile=0.788; target-priority score=79.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 519 ML1699 Q7AQ26 ML1699 Lipoprotein 372 0.13353 non-essential 0.20051 non-essential high NA medium_confidence NP_217522.1 86.2 0.402 56.046 Moderate candidate ESM-2 calibrated P(essential)=0.134; HANSEN integrated essentiality score=0.201; ProteomeLM contextual percentile=0.402; target-priority score=56.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 520 ML1140 P45828 atpE ML1140 ATP synthase subunit c (ATP synthase F(0) sector subunit c) (F-type ATPase subunit c) (F-ATPase subunit c) (Lipid-binding protein) 81 0.05628 non-essential 0.20012 non-essential high NA medium_confidence NP_215821.1 92.6 0.71196 70.381 Strong candidate ESM-2 calibrated P(essential)=0.056; HANSEN integrated essentiality score=0.200; ProteomeLM contextual percentile=0.712; target-priority score=70.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 521 ML1925 Q9CBI6 sodC ML1925 Superoxide dismutase [Cu-Zn] (EC 1.15.1.1) 240 0.03079 non-essential 0.19998 non-essential high NA high_confidence_nonessential NP_214946.1 72.3 0.79962 80.054 High-priority ESM-2 calibrated P(essential)=0.031; HANSEN integrated essentiality score=0.200; ProteomeLM contextual percentile=0.800; target-priority score=80.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 522 ML1018 Q9CCB3 ML1018 Uncharacterized protein 71 0.00198 non-essential 0.19994 non-essential high NA high_confidence_nonessential 0.9618 69.787 Strong candidate ESM-2 calibrated P(essential)=0.002; HANSEN integrated essentiality score=0.200; ProteomeLM contextual percentile=0.962; target-priority score=69.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 523 ML2680 P46394 dnaB ML2680 MLCB1913.16c Replicative DNA helicase DnaB (EC 5.6.2.3) (DNA 5'-3' helicase DnaB) [Cleaved into: Mle DnaB intein (EC 3.1.-.-)] 604 0.08956 non-essential 0.19944 non-essential high NA high_confidence_nonessential NP_214572.1 67.5 0.5479 72.865 Strong candidate ESM-2 calibrated P(essential)=0.090; HANSEN integrated essentiality score=0.199; ProteomeLM contextual percentile=0.548; target-priority score=72.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 524 ML0638 Q49769 ML0638 B1937_F3_110 Uncharacterized protein ML0638 100 0.00198 non-essential 0.19926 non-essential high NA high_confidence_nonessential 0.95304 71.401 Strong candidate ESM-2 calibrated P(essential)=0.002; HANSEN integrated essentiality score=0.199; ProteomeLM contextual percentile=0.953; target-priority score=71.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 525 ML1024 P46813 suhB ssyA ML1024 Inositol-1-monophosphatase (I-1-Pase) (IMPase) (Inositol-1-phosphatase) (EC 3.1.3.25) 291 0.0822 non-essential 0.19919 non-essential high NA high_confidence_nonessential NP_217217.1 76.4 0.57733 73.847 Strong candidate ESM-2 calibrated P(essential)=0.082; HANSEN integrated essentiality score=0.199; ProteomeLM contextual percentile=0.577; target-priority score=73.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 526 ML0726 P46392 bccA ML0726 B1308_C1_129 Biotin-dependent acyl-coenzyme A carboxylase alpha3 subunit [Includes: Biotin carboxylase (BC) (EC 6.3.4.14); Biotin carboxyl carrier protein (BCCP)] 598 0.13353 non-essential 0.19903 non-essential high NA high_confidence_nonessential NP_217802.1 86.0 0.34878 71.174 Strong candidate ESM-2 calibrated P(essential)=0.134; HANSEN integrated essentiality score=0.199; ProteomeLM contextual percentile=0.349; target-priority score=71.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 527 ML1859 O32985 rpsS ML1859 MLCB2492.06 Small ribosomal subunit protein uS19 (30S ribosomal protein S19) 93 0.1873 non-essential 0.1988 non-essential high NA high_confidence_nonessential NP_215219.1 96.8 0.16155 50.498 Moderate candidate ESM-2 calibrated P(essential)=0.187; HANSEN integrated essentiality score=0.199; ProteomeLM contextual percentile=0.162; target-priority score=50.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 528 ML1165 P53423 clpS ML1165 B1549_C2_207 ATP-dependent Clp protease adapter protein ClpS 108 0.07502 non-essential 0.19879 non-essential high NA high_confidence_nonessential NP_215847.1 84.2 0.63244 65.524 Strong candidate ESM-2 calibrated P(essential)=0.075; HANSEN integrated essentiality score=0.199; ProteomeLM contextual percentile=0.632; target-priority score=65.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 529 ML0777 Q9CCI8 ML0777 Uncharacterized protein 64 0.00543 non-essential 0.19879 non-essential high NA high_confidence_nonessential 0.93738 70.394 Strong candidate ESM-2 calibrated P(essential)=0.005; HANSEN integrated essentiality score=0.199; ProteomeLM contextual percentile=0.937; target-priority score=70.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 530 ML0715 Q9CCL5 lpqC ML0715 Secreted hydrolase 304 0.01942 non-essential 0.19877 non-essential high NA high_confidence_nonessential NP_217815.1 72.0 0.85723 75.786 Strong candidate ESM-2 calibrated P(essential)=0.019; HANSEN integrated essentiality score=0.199; ProteomeLM contextual percentile=0.857; target-priority score=75.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 531 ML0070 Q9CDC8 ML0070 Uncharacterized protein 87 0.01019 non-essential 0.19859 non-essential high NA high_confidence_nonessential 0.91922 68.738 Strong candidate ESM-2 calibrated P(essential)=0.010; HANSEN integrated essentiality score=0.199; ProteomeLM contextual percentile=0.919; target-priority score=68.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 532 ML1976 Q9CBH4 ML1976 Uncharacterized protein 115 0.00543 non-essential 0.19836 non-essential high NA high_confidence_nonessential 0.93801 69.329 Strong candidate ESM-2 calibrated P(essential)=0.005; HANSEN integrated essentiality score=0.198; ProteomeLM contextual percentile=0.938; target-priority score=69.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 533 ML2162 Q9CBD7 fadA ML2162 Beta-ketoadipyl CoA thiolase 403 0.09148 non-essential 0.19828 non-essential high NA high_confidence_nonessential NP_215374.1 94.5 0.54728 67.78 Strong candidate ESM-2 calibrated P(essential)=0.091; HANSEN integrated essentiality score=0.198; ProteomeLM contextual percentile=0.547; target-priority score=67.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 534 ML1753 Q9CBP3 ML1753 Possible transcriptional regulator 1106 0.04897 non-essential 0.19825 non-essential high NA high_confidence_nonessential NP_215874.1 58.1 0.73763 69.311 Strong candidate ESM-2 calibrated P(essential)=0.049; HANSEN integrated essentiality score=0.198; ProteomeLM contextual percentile=0.738; target-priority score=69.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:45Z 535 ML1275 Q9CC51 ML1275 Uncharacterized protein 78 0.00198 non-essential 0.19806 non-essential high NA high_confidence_nonessential 0.94803 70.705 Strong candidate ESM-2 calibrated P(essential)=0.002; HANSEN integrated essentiality score=0.198; ProteomeLM contextual percentile=0.948; target-priority score=70.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 536 ML0949 Q9CCD1 ML0949 HTH tetR-type domain-containing protein 137 0.00198 non-essential 0.19792 non-essential high NA high_confidence_nonessential 0.93989 73.199 Strong candidate ESM-2 calibrated P(essential)=0.002; HANSEN integrated essentiality score=0.198; ProteomeLM contextual percentile=0.940; target-priority score=73.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 537 ML1788 Q7AQ24 ML1788 Uncharacterized protein 154 0.00543 non-essential 0.19791 non-essential high NA high_confidence_nonessential 0.9355 69.277 Strong candidate ESM-2 calibrated P(essential)=0.005; HANSEN integrated essentiality score=0.198; ProteomeLM contextual percentile=0.936; target-priority score=69.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 538 ML1532 Q9CBV6 ald ML1532 Alanine dehydrogenase (EC 1.4.1.1) 371 0.10418 non-essential 0.19783 non-essential high NA high_confidence_nonessential NP_217296.1 85.4 0.4665 74.539 Strong candidate ESM-2 calibrated P(essential)=0.104; HANSEN integrated essentiality score=0.198; ProteomeLM contextual percentile=0.466; target-priority score=74.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 539 ML1316 P46509 mpa ML1316 a2126a B2126_C1_167 MLCB2533.12 Proteasome-associated ATPase (AAA ATPase forming ring-shaped complexes) (ARC) (Mycobacterial proteasome ATPase) 609 0.19405 non-essential 0.19774 non-essential high NA high_confidence_nonessential NP_216631.1 92.9 0.11709 52.947 Moderate candidate ESM-2 calibrated P(essential)=0.194; HANSEN integrated essentiality score=0.198; ProteomeLM contextual percentile=0.117; target-priority score=52.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 540 ML0700 Q9CCL9 add ML0700 L308_C2_206 Adenosine deaminase (EC 3.5.4.4) (Adenosine aminohydrolase) 362 0.10418 non-essential 0.19773 non-essential high NA high_confidence_nonessential NP_217830.1 88.2 0.47714 70.708 Strong candidate ESM-2 calibrated P(essential)=0.104; HANSEN integrated essentiality score=0.198; ProteomeLM contextual percentile=0.477; target-priority score=70.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 541 ML1705 O33102 ligA lig ML1705 MLCB637.10 DNA ligase (EC 6.5.1.2) (Polydeoxyribonucleotide synthase [NAD(+)]) 694 0.19217 non-essential 0.19766 non-essential high NA high_confidence_nonessential NP_217530.1 84.9 0.10708 59.132 Moderate candidate ESM-2 calibrated P(essential)=0.192; HANSEN integrated essentiality score=0.198; ProteomeLM contextual percentile=0.107; target-priority score=59.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 542 ML1793 Q9CBN0 ML1793 Uncharacterized protein 101 0.00198 non-essential 0.19766 non-essential high NA high_confidence_nonessential 0.94615 70.546 Strong candidate ESM-2 calibrated P(essential)=0.002; HANSEN integrated essentiality score=0.198; ProteomeLM contextual percentile=0.946; target-priority score=70.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 543 ML2461 Q9CB39 fadB2 ML2461 3-hydroxyacyl-CoA dehydrogenase 287 0.08382 non-essential 0.19752 non-essential high NA high_confidence_nonessential NP_214982.1 89.9 0.56919 70.763 Strong candidate ESM-2 calibrated P(essential)=0.084; HANSEN integrated essentiality score=0.198; ProteomeLM contextual percentile=0.569; target-priority score=70.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 544 ML2355 Q49933 ML2355 Polyketide synthase 2201 0.03604 non-essential 0.19741 non-essential high NA high_confidence_nonessential NP_217449.1 81.7 0.77959 73.542 Strong candidate ESM-2 calibrated P(essential)=0.036; HANSEN integrated essentiality score=0.197; ProteomeLM contextual percentile=0.780; target-priority score=73.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:45Z 545 ML0152 Q9CD73 ML0152 Uncharacterized protein 62 0.00543 non-essential 0.1974 non-essential high NA high_confidence_nonessential 0.93112 69.755 Strong candidate ESM-2 calibrated P(essential)=0.005; HANSEN integrated essentiality score=0.197; ProteomeLM contextual percentile=0.931; target-priority score=69.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 546 ML0447 Q9CCU2 ML0447 Cytochrome P450 158 0.00674 non-essential 0.19703 non-essential high NA high_confidence_nonessential 0.91296 73.142 Strong candidate ESM-2 calibrated P(essential)=0.007; HANSEN integrated essentiality score=0.197; ProteomeLM contextual percentile=0.913; target-priority score=73.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 547 ML2497 Q9CB22 ML2497 TetR-family transcriptional regulator 157 0.02105 non-essential 0.19694 non-essential high NA high_confidence_nonessential 0.84659 73.206 Strong candidate ESM-2 calibrated P(essential)=0.021; HANSEN integrated essentiality score=0.197; ProteomeLM contextual percentile=0.847; target-priority score=73.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 548 ML2474 Q9CB32 tadA ML2474 tRNA-specific adenosine deaminase (EC 3.5.4.33) 171 0.01648 non-essential 0.19693 non-essential high NA high_confidence_nonessential NP_218269.1 87.4 0.83907 82.859 High-priority ESM-2 calibrated P(essential)=0.016; HANSEN integrated essentiality score=0.197; ProteomeLM contextual percentile=0.839; target-priority score=82.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 549 ML0200 O69548 topA ML0200 MLCB2548.31c DNA topoisomerase 1 (EC 5.6.2.1) (DNA topoisomerase I) (Omega-protein) (Relaxing enzyme) (Swivelase) (Untwisting enzyme) 947 0.18914 non-essential 0.19683 non-essential high NA high_confidence_nonessential NP_218163.1 84.8 0.1221 57.079 Moderate candidate ESM-2 calibrated P(essential)=0.189; HANSEN integrated essentiality score=0.197; ProteomeLM contextual percentile=0.122; target-priority score=57.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:45Z 550 ML1616 O33016 rimM ML1616 MLCB250.34 Ribosome maturation factor RimM 179 0.1035 non-essential 0.19669 non-essential high NA high_confidence_nonessential NP_217423.1 73.1 0.49843 62.441 Moderate candidate ESM-2 calibrated P(essential)=0.104; HANSEN integrated essentiality score=0.197; ProteomeLM contextual percentile=0.498; target-priority score=62.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 551 ML0348 Q9CCV8 ML0348 Possible coenzyme F420-dependent oxidoreductase 350 0.06199 non-essential 0.19664 non-essential high NA high_confidence_nonessential NP_218037.1 86.8 0.66813 69.412 Strong candidate ESM-2 calibrated P(essential)=0.062; HANSEN integrated essentiality score=0.197; ProteomeLM contextual percentile=0.668; target-priority score=69.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 552 ML1979 Q9CBH3 ML1979 Uncharacterized protein 135 0.00198 non-essential 0.1965 non-essential high NA high_confidence_nonessential 0.94051 70.138 Strong candidate ESM-2 calibrated P(essential)=0.002; HANSEN integrated essentiality score=0.197; ProteomeLM contextual percentile=0.941; target-priority score=70.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 553 ML0218 Q7AQL5 ML0218 Uncharacterized protein 128 0.01019 non-essential 0.19644 non-essential high NA high_confidence_nonessential 0.9067 68.714 Strong candidate ESM-2 calibrated P(essential)=0.010; HANSEN integrated essentiality score=0.196; ProteomeLM contextual percentile=0.907; target-priority score=68.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 554 ML0234 P24094 lsr2 ML0234 Nucleoid-associated protein Lsr2 (15 kDa antigen) (A15) 112 0.09148 non-essential 0.19634 non-essential high NA high_confidence_nonessential NP_218114.1 88.4 0.55354 61.757 Moderate candidate ESM-2 calibrated P(essential)=0.091; HANSEN integrated essentiality score=0.196; ProteomeLM contextual percentile=0.554; target-priority score=61.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 555 ML1602 Q9CBT9 ML1602 Uncharacterized protein 106 0.00198 non-essential 0.19629 non-essential high NA high_confidence_nonessential 0.93676 70.998 Strong candidate ESM-2 calibrated P(essential)=0.002; HANSEN integrated essentiality score=0.196; ProteomeLM contextual percentile=0.937; target-priority score=71.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 556 ML0050 O33084 esxB ML0050 MLCB628.13c ESAT-6-like protein EsxB 100 0.01412 non-essential 0.19628 non-essential high NA high_confidence_nonessential 0.87414 73.326 Strong candidate ESM-2 calibrated P(essential)=0.014; HANSEN integrated essentiality score=0.196; ProteomeLM contextual percentile=0.874; target-priority score=73.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 557 ML0604 O33132 rpsT ML0604 MLCL536.06 Small ribosomal subunit protein bS20 (30S ribosomal protein S20) 86 0.03102 non-essential 0.19619 non-essential high NA high_confidence_nonessential NP_216928.1 88.4 0.79399 74.036 Strong candidate ESM-2 calibrated P(essential)=0.031; HANSEN integrated essentiality score=0.196; ProteomeLM contextual percentile=0.794; target-priority score=74.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 558 ML0984 Q9CCC2 ML0984 Limonene-1,2-epoxide hydrolase domain-containing protein 164 0.0 non-essential 0.19617 non-essential high NA high_confidence_nonessential NP_217256.1 50.7 0.92987 76.189 Strong candidate ESM-2 calibrated P(essential)=0.000; HANSEN integrated essentiality score=0.196; ProteomeLM contextual percentile=0.930; target-priority score=76.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 559 ML2396 Q9CB65 cysM2 ML2396 Cystathionine beta-synthase (EC 4.2.1.22) 464 0.10418 non-essential 0.196 non-essential high NA high_confidence_nonessential YP_177782.1 90.1 0.47589 67.692 Strong candidate ESM-2 calibrated P(essential)=0.104; HANSEN integrated essentiality score=0.196; ProteomeLM contextual percentile=0.476; target-priority score=67.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 560 ML2206 Q50028 purF ML2206 MLCB5.38 Amidophosphoribosyltransferase (ATase) (EC 2.4.2.14) (Glutamine phosphoribosylpyrophosphate amidotransferase) (GPATase) 556 0.0515 non-essential 0.19592 non-essential high NA high_confidence_nonessential NP_215323.1 91.3 0.6819 79.649 Strong candidate ESM-2 calibrated P(essential)=0.051; HANSEN integrated essentiality score=0.196; ProteomeLM contextual percentile=0.682; target-priority score=79.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 561 ML1909 Q9CBJ7 ML1909 MaoC-like domain-containing protein 142 0.08138 non-essential 0.19591 non-essential high NA high_confidence_nonessential NP_215150.1 93.0 0.58735 65.158 Strong candidate ESM-2 calibrated P(essential)=0.081; HANSEN integrated essentiality score=0.196; ProteomeLM contextual percentile=0.587; target-priority score=65.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 562 ML1726 Q9CBQ7 ML1726 ABC transporter protein, ATP-binding component 305 0.06636 non-essential 0.19573 non-essential high NA high_confidence_nonessential NP_217557.1 83.4 0.65185 66.312 Strong candidate ESM-2 calibrated P(essential)=0.066; HANSEN integrated essentiality score=0.196; ProteomeLM contextual percentile=0.652; target-priority score=66.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 563 ML1610 Q7AQ38 ML1610 Protein often found in Actinomycetes clustered with signal peptidase and/or RNaseHII 101 0.13799 non-essential 0.19571 non-essential high agree high_confidence_nonessential Rv2901c 99.0 NE 0 0.78147 69.551 Strong candidate ESM-2 calibrated P(essential)=0.138; HANSEN integrated essentiality score=0.196; Mtb RBH anchor Rv2901c=non-essential (agree); ProteomeLM contextual percentile=0.781; target-priority score=69.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 564 ML0946 Q7AQC3 ML0946 Uncharacterized protein 107 0.0 non-essential 0.19551 non-essential high NA high_confidence_nonessential 0.94364 70.189 Strong candidate ESM-2 calibrated P(essential)=0.000; HANSEN integrated essentiality score=0.196; ProteomeLM contextual percentile=0.944; target-priority score=70.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 565 ML1656 O69473 kasB ML1656 MLCB1243.19c 3-oxoacyl-[acyl-carrier-protein] synthase 2 (EC 2.3.1.294) (Beta-ketoacyl-ACP synthase 2) (KAS 2) 420 0.06981 non-essential 0.19517 non-essential high NA high_confidence_nonessential NP_216762.1 91.6 0.59299 79.816 Strong candidate ESM-2 calibrated P(essential)=0.070; HANSEN integrated essentiality score=0.195; ProteomeLM contextual percentile=0.593; target-priority score=79.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 566 ML2192 Q50043 phoS3 ML2192 Phosphate-binding protein 429 0.01709 non-essential 0.19503 non-essential high NA high_confidence_nonessential 0.84784 75.139 Strong candidate ESM-2 calibrated P(essential)=0.017; HANSEN integrated essentiality score=0.195; ProteomeLM contextual percentile=0.848; target-priority score=75.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 567 ML1113 Q9CC89 ML1113 Fatty acid ABC transporter ATP-binding/permease protein 629 0.09638 non-essential 0.19488 non-essential high NA high_confidence_nonessential NP_215788.1 75.3 0.52536 60.787 Moderate candidate ESM-2 calibrated P(essential)=0.096; HANSEN integrated essentiality score=0.195; ProteomeLM contextual percentile=0.525; target-priority score=60.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 568 ML2088 Q9CBE7 ML2088 Cytochrome p450 434 0.06543 non-essential 0.19488 non-essential high NA high_confidence_nonessential NP_216396.3 37.5 0.64684 67.757 Strong candidate ESM-2 calibrated P(essential)=0.065; HANSEN integrated essentiality score=0.195; ProteomeLM contextual percentile=0.647; target-priority score=67.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 569 ML2198 Q50036 cysA cysA3 ML2198 Putative thiosulfate sulfurtransferase (EC 2.8.1.1) (Rhodanese-like protein) 277 0.10695 non-essential 0.19485 non-essential high NA high_confidence_nonessential NP_215330.1 85.2 0.45022 69.78 Strong candidate ESM-2 calibrated P(essential)=0.107; HANSEN integrated essentiality score=0.195; ProteomeLM contextual percentile=0.450; target-priority score=69.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 570 ML1331 P54079 tatA ML1331 B2126_C1_182 MLCB2533.27 u2126b Sec-independent protein translocase protein TatA 88 0.00674 non-essential 0.19481 non-essential high NA high_confidence_nonessential NP_216610.1 69.3 0.90545 71.249 Strong candidate ESM-2 calibrated P(essential)=0.007; HANSEN integrated essentiality score=0.195; ProteomeLM contextual percentile=0.905; target-priority score=71.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 571 ML0106 Q9CDA7 embC ML0106 Probable arabinosyltransferase C (EC 2.4.2.-) 1070 0.0912 non-essential 0.19467 non-essential high NA high_confidence_nonessential NP_218310.1 82.4 0.52786 67.599 Strong candidate ESM-2 calibrated P(essential)=0.091; HANSEN integrated essentiality score=0.195; ProteomeLM contextual percentile=0.528; target-priority score=67.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:45Z 572 ML1795 P12809 hsp18 ML1795 18 kDa antigen (HSP 16.7) 148 0.01889 non-essential 0.19456 non-essential high NA high_confidence_nonessential 0.84909 70.974 Strong candidate ESM-2 calibrated P(essential)=0.019; HANSEN integrated essentiality score=0.195; ProteomeLM contextual percentile=0.849; target-priority score=71.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 573 ML0048 Q9CDD8 ML0048 CobQ/CobB/MinD/ParA nucleotide binding domain-containing protein 586 0.04805 non-essential 0.19435 non-essential high NA high_confidence_nonessential NP_218393.1 55.9 0.72574 66.996 Strong candidate ESM-2 calibrated P(essential)=0.048; HANSEN integrated essentiality score=0.194; ProteomeLM contextual percentile=0.726; target-priority score=67.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 574 ML1679 Q9CBR9 gpsA ML1679 MLCB637.38 Glycerol-3-phosphate dehydrogenase [NAD(P)+] (EC 1.1.1.94) (NAD(P)(+)-dependent glycerol-3-phosphate dehydrogenase) (NAD(P)H-dependent dihydroxyacetone-phosphate reductase) 349 0.06981 non-essential 0.19413 non-essential high NA high_confidence_nonessential NP_217498.1 77.9 0.58923 79.023 Strong candidate ESM-2 calibrated P(essential)=0.070; HANSEN integrated essentiality score=0.194; ProteomeLM contextual percentile=0.589; target-priority score=79.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 575 ML0097 Q05861 fbpA ML0097 Diacylglycerol acyltransferase/mycolyltransferase Ag85A (DGAT) (EC 2.3.1.122) (EC 2.3.1.20) (Acyl-CoA:diacylglycerol acyltransferase) (Antigen 85 complex A) (85A) (Ag85A) (Fibronectin-binding protein A) (Fbps A) 330 0.09459 non-essential 0.19403 non-essential high NA high_confidence_nonessential NP_218321.1 83.0 0.49718 71.451 Strong candidate ESM-2 calibrated P(essential)=0.095; HANSEN integrated essentiality score=0.194; ProteomeLM contextual percentile=0.497; target-priority score=71.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 576 ML2352 Q49938 ML2352 Probable antibiotic resistance efflux protein 331 0.13176 non-essential 0.19395 non-essential high NA high_confidence_nonessential NP_217452.1 85.2 0.3707 56.327 Moderate candidate ESM-2 calibrated P(essential)=0.132; HANSEN integrated essentiality score=0.194; ProteomeLM contextual percentile=0.371; target-priority score=56.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 577 ML0101 Q9CDB1 pks13 ML0101 Polyketide synthase 1784 0.09638 non-essential 0.19385 non-essential high NA high_confidence_nonessential NP_218317.1 83.5 0.51659 61.7 Moderate candidate ESM-2 calibrated P(essential)=0.096; HANSEN integrated essentiality score=0.194; ProteomeLM contextual percentile=0.517; target-priority score=61.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:45Z 578 ML2335 Q7APW2 dnaZX dnaX ML2335 DNA polymerase III subunit gamma/tau (EC 2.7.7.7) 611 0.18413 non-essential 0.19384 non-essential high NA high_confidence_nonessential NP_218238.1 78.2 0.13338 55.093 Moderate candidate ESM-2 calibrated P(essential)=0.184; HANSEN integrated essentiality score=0.194; ProteomeLM contextual percentile=0.133; target-priority score=55.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 579 ML2015 Q9X7D6 cinA ML2015 MLCB561.17 CinA-like protein 428 0.06981 non-essential 0.19378 non-essential high NA high_confidence_nonessential NP_216417.1 77.0 0.63056 64.269 Moderate candidate ESM-2 calibrated P(essential)=0.070; HANSEN integrated essentiality score=0.194; ProteomeLM contextual percentile=0.631; target-priority score=64.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 580 ML2671 O53114 ctpI ML2671 MLCB1913.02 Probable cation-transporting ATPase I (EC 7.2.2.-) 1609 0.05767 non-essential 0.19377 non-essential high NA high_confidence_nonessential NP_214621.1 81.4 0.65748 74.026 Strong candidate ESM-2 calibrated P(essential)=0.058; HANSEN integrated essentiality score=0.194; ProteomeLM contextual percentile=0.657; target-priority score=74.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:45Z 581 ML2284 Q9CBA1 ML2284 Uncharacterized protein 119 0.00674 non-essential 0.19367 non-essential high NA high_confidence_nonessential 0.90294 69.821 Strong candidate ESM-2 calibrated P(essential)=0.007; HANSEN integrated essentiality score=0.194; ProteomeLM contextual percentile=0.903; target-priority score=69.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 582 ML0959 Q9CCC5 ML0959 Uncharacterized protein 117 0.00198 non-essential 0.1936 non-essential high NA high_confidence_nonessential 0.92736 68.8 Strong candidate ESM-2 calibrated P(essential)=0.002; HANSEN integrated essentiality score=0.194; ProteomeLM contextual percentile=0.927; target-priority score=68.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 583 ML0023 Q9CDE3 ML0023 Uncharacterized protein 103 0.00198 non-essential 0.19356 non-essential high NA high_confidence_nonessential 0.92048 71.076 Strong candidate ESM-2 calibrated P(essential)=0.002; HANSEN integrated essentiality score=0.194; ProteomeLM contextual percentile=0.920; target-priority score=71.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 584 ML1430 Q9CC06 ML1430 Possible membrane protein 108 0.00198 non-essential 0.19346 non-essential high NA high_confidence_nonessential 0.91672 72.14 Strong candidate ESM-2 calibrated P(essential)=0.002; HANSEN integrated essentiality score=0.193; ProteomeLM contextual percentile=0.917; target-priority score=72.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 585 ML0246 Q9CD47 lpqT ML0246 Putative lipoprotein LpqT 218 0.02105 non-essential 0.19333 non-essential high NA high_confidence_nonessential NP_215532.1 65.3 0.82905 71.93 Strong candidate ESM-2 calibrated P(essential)=0.021; HANSEN integrated essentiality score=0.193; ProteomeLM contextual percentile=0.829; target-priority score=71.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 586 ML0453 Q7AQJ0 ML0453 Phosphatidylinositol mannoside acyltransferase 320 0.05767 non-essential 0.19331 non-essential high NA high_confidence_nonessential NP_217127.1 70.4 0.67001 68.851 Strong candidate ESM-2 calibrated P(essential)=0.058; HANSEN integrated essentiality score=0.193; ProteomeLM contextual percentile=0.670; target-priority score=68.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 587 ML1729 Q9CBQ4 fecB ML1729 FeIII-dicitrate transporter lipoprotein 364 0.05001 non-essential 0.19327 non-essential high NA high_confidence_nonessential NP_217560.1 75.6 0.7057 68.595 Strong candidate ESM-2 calibrated P(essential)=0.050; HANSEN integrated essentiality score=0.193; ProteomeLM contextual percentile=0.706; target-priority score=68.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 588 ML1070 Q7AQ94 ML1070 TetR-family transcriptional regulator 217 0.0733 non-essential 0.19324 non-essential high NA high_confidence_nonessential 0.60739 65.624 Strong candidate ESM-2 calibrated P(essential)=0.073; HANSEN integrated essentiality score=0.193; ProteomeLM contextual percentile=0.607; target-priority score=65.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 589 ML0316 Q9CCW8 ML0316 TetR/AcrR-family transcriptional regulator 200 0.04897 non-essential 0.19304 non-essential high NA high_confidence_nonessential NP_214581.1 68.8 0.70695 69.326 Strong candidate ESM-2 calibrated P(essential)=0.049; HANSEN integrated essentiality score=0.193; ProteomeLM contextual percentile=0.707; target-priority score=69.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 590 ML1812 Q9CBL5 ML1812 Exported p60 protein homologue 479 0.12863 non-essential 0.19299 non-essential high NA high_confidence_nonessential NP_215993.1 77.3 0.38009 56.095 Moderate candidate ESM-2 calibrated P(essential)=0.129; HANSEN integrated essentiality score=0.193; ProteomeLM contextual percentile=0.380; target-priority score=56.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 591 ML0397 Q9CCU8 ML0397 Transporter protein 602 0.02338 non-essential 0.19284 non-essential high NA high_confidence_nonessential 0.81403 72.454 Strong candidate ESM-2 calibrated P(essential)=0.023; HANSEN integrated essentiality score=0.193; ProteomeLM contextual percentile=0.814; target-priority score=72.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 592 ML2348 Q49929 ML2348 L518_C2_147 MLCB2407.02c Uncharacterized glycosyltransferase ML2348 (EC 2.4.-.-) 421 0.03424 non-essential 0.19249 non-essential high NA high_confidence_nonessential NP_216040.1 62.9 0.75454 75.029 Strong candidate ESM-2 calibrated P(essential)=0.034; HANSEN integrated essentiality score=0.192; ProteomeLM contextual percentile=0.755; target-priority score=75.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 593 ML0135 Q9CD81 ML0135 Polyketide synthase 2103 0.06543 non-essential 0.19237 non-essential high NA high_confidence_nonessential NP_217462.1 82.0 0.62179 71.263 Strong candidate ESM-2 calibrated P(essential)=0.065; HANSEN integrated essentiality score=0.192; ProteomeLM contextual percentile=0.622; target-priority score=71.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:45Z 594 ML0233 P46861 lysS ML0233 Lysine--tRNA ligase (EC 6.1.1.6) (Lysyl-tRNA synthetase) (LysRS) 507 0.10115 non-essential 0.19213 non-essential high NA high_confidence_nonessential NP_218115.1 85.4 0.45648 71.269 Strong candidate ESM-2 calibrated P(essential)=0.101; HANSEN integrated essentiality score=0.192; ProteomeLM contextual percentile=0.456; target-priority score=71.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 595 ML0755 Q9CCK5 ML0755 NUDIX hydrolase 86 0.00198 non-essential 0.19212 non-essential high NA high_confidence_nonessential 0.90607 73.094 Strong candidate ESM-2 calibrated P(essential)=0.002; HANSEN integrated essentiality score=0.192; ProteomeLM contextual percentile=0.906; target-priority score=73.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 596 ML1368 Q7AQ60 ML1368 Segregation and condensation protein A 268 0.06652 non-essential 0.1919 non-essential high NA high_confidence_nonessential NP_216225.1 78.9 0.63807 63.094 Moderate candidate ESM-2 calibrated P(essential)=0.067; HANSEN integrated essentiality score=0.192; ProteomeLM contextual percentile=0.638; target-priority score=63.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 597 ML1993 Q9CBG3 ML1993 (2E)-enoyl-[ACP] glycyltransferase (EC 4.3.2.11) ((2E)-unsaturated fatty acyl-[ACP] glycyltransferase) 183 0.00543 non-essential 0.1919 non-essential high NA high_confidence_nonessential NP_214612.1 68.0 0.86412 81.523 High-priority ESM-2 calibrated P(essential)=0.005; HANSEN integrated essentiality score=0.192; ProteomeLM contextual percentile=0.864; target-priority score=81.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 598 ML0283 Q9CCX3 ML0283 Cation-efflux transporter component 268 0.00543 non-essential 0.19188 non-essential high NA high_confidence_nonessential 0.88854 73.179 Strong candidate ESM-2 calibrated P(essential)=0.005; HANSEN integrated essentiality score=0.192; ProteomeLM contextual percentile=0.889; target-priority score=73.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 599 ML0734 Q7AQF6 ML0734 Membrane protein 228 0.02682 non-essential 0.19185 non-essential high NA high_confidence_nonessential NP_217794.1 84.2 0.799 70.187 Strong candidate ESM-2 calibrated P(essential)=0.027; HANSEN integrated essentiality score=0.192; ProteomeLM contextual percentile=0.799; target-priority score=70.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 600 ML2172 Q9CBD4 ML2172 Uncharacterized protein 118 0.01233 non-essential 0.19177 non-essential high NA high_confidence_nonessential 0.87351 67.314 Strong candidate ESM-2 calibrated P(essential)=0.012; HANSEN integrated essentiality score=0.192; ProteomeLM contextual percentile=0.874; target-priority score=67.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 601 ML1915 Q9CBJ3 ML1915 Uncharacterized protein 114 0.01412 non-essential 0.1917 non-essential high NA high_confidence_nonessential 0.85974 69.054 Strong candidate ESM-2 calibrated P(essential)=0.014; HANSEN integrated essentiality score=0.192; ProteomeLM contextual percentile=0.860; target-priority score=69.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 602 ML2341 Q9CB72 ML2341 Possible regulatory protein 732 0.056 non-essential 0.19163 non-essential high NA high_confidence_nonessential 0.67251 67.24 Strong candidate ESM-2 calibrated P(essential)=0.056; HANSEN integrated essentiality score=0.192; ProteomeLM contextual percentile=0.673; target-priority score=67.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 603 ML2356 Q7APV9 ML2356 Polyketide synthase 1540 0.02338 non-essential 0.19156 non-essential high NA high_confidence_nonessential NP_217448.1 75.8 0.80902 71.587 Strong candidate ESM-2 calibrated P(essential)=0.023; HANSEN integrated essentiality score=0.192; ProteomeLM contextual percentile=0.809; target-priority score=71.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:45Z 604 ML0551 Q9CCQ1 ML0551 Methyltransferase 274 0.01648 non-essential 0.19155 non-essential high NA high_confidence_nonessential NP_215921.1 78.0 0.83093 74.875 Strong candidate ESM-2 calibrated P(essential)=0.016; HANSEN integrated essentiality score=0.192; ProteomeLM contextual percentile=0.831; target-priority score=74.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 605 ML0492 P46697 ppiB ppi ML0492 B1177_F3_97 MLCB1259.10c Probable peptidyl-prolyl cis-trans isomerase B (PPIase B) (EC 5.2.1.8) (Rotamase B) 295 0.03079 non-essential 0.19149 non-essential high NA high_confidence_nonessential NP_217098.1 76.9 0.75955 76.692 Strong candidate ESM-2 calibrated P(essential)=0.031; HANSEN integrated essentiality score=0.191; ProteomeLM contextual percentile=0.760; target-priority score=76.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 606 ML2069 O32913 glcB ML2069 MLCB1788.27 Malate synthase G (EC 2.3.3.9) 731 0.19217 non-essential 0.19148 non-essential high NA high_confidence_nonessential NP_216353.1 82.1 0.06888 59.758 Moderate candidate ESM-2 calibrated P(essential)=0.192; HANSEN integrated essentiality score=0.191; ProteomeLM contextual percentile=0.069; target-priority score=59.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 607 ML0858 O32962 lipA ML0858 MLCB22.20 Lipoyl synthase (EC 2.8.1.8) (Lip-syn) (LS) (Lipoate synthase) (Lipoic acid synthase) (Sulfur insertion protein LipA) 314 0.09148 non-essential 0.19141 non-essential high NA high_confidence_nonessential NP_216734.1 86.8 0.48904 73.84 Strong candidate ESM-2 calibrated P(essential)=0.091; HANSEN integrated essentiality score=0.191; ProteomeLM contextual percentile=0.489; target-priority score=73.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 608 ML0321 Q9CCW6 ispD ML0321 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase (EC 2.7.7.60) (4-diphosphocytidyl-2C-methyl-D-erythritol synthase) (MEP cytidylyltransferase) (MCT) 241 0.06341 non-essential 0.19133 non-essential high NA high_confidence_nonessential NP_218099.1 66.9 0.60927 76.581 Strong candidate ESM-2 calibrated P(essential)=0.063; HANSEN integrated essentiality score=0.191; ProteomeLM contextual percentile=0.609; target-priority score=76.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 609 ML0295 Q9ZBL1 thiD ML0295 MLCB1450.27c Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase (EC 2.7.1.49) (EC 2.7.4.7) (Hydroxymethylpyrimidine kinase) (HMP kinase) (Hydroxymethylpyrimidine phosphate kinase) (HMP-P kinase) (HMP-phosphate kinase) (HMPP kinase) 279 0.09148 non-essential 0.19132 non-essential high NA high_confidence_nonessential NP_214936.1 77.8 0.48528 74.928 Strong candidate ESM-2 calibrated P(essential)=0.091; HANSEN integrated essentiality score=0.191; ProteomeLM contextual percentile=0.485; target-priority score=74.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 610 ML1135 P45832 prmC hemK ML1135 Release factor glutamine methyltransferase (RF MTase) (EC 2.1.1.297) (M.MleHemKP) (N5-glutamine methyltransferase PrmC) (Protein-(glutamine-N5) MTase PrmC) (Protein-glutamine N-methyltransferase PrmC) 288 0.04552 non-essential 0.19111 non-essential high NA high_confidence_nonessential NP_215816.1 74.5 0.68566 78.085 Strong candidate ESM-2 calibrated P(essential)=0.046; HANSEN integrated essentiality score=0.191; ProteomeLM contextual percentile=0.686; target-priority score=78.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 611 ML1420 Q7AQ56 ML1420 Uncharacterized protein 117 0.00198 non-essential 0.19103 non-essential high NA high_confidence_nonessential 0.91234 68.773 Strong candidate ESM-2 calibrated P(essential)=0.002; HANSEN integrated essentiality score=0.191; ProteomeLM contextual percentile=0.912; target-priority score=68.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 612 ML2312 Q9CB83 ML2312 Possible membrane protein 196 0.00543 non-essential 0.19099 non-essential high NA high_confidence_nonessential NP_218212.1 70.5 0.89105 70.565 Strong candidate ESM-2 calibrated P(essential)=0.005; HANSEN integrated essentiality score=0.191; ProteomeLM contextual percentile=0.891; target-priority score=70.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 613 ML1277 Q9CC49 pykA ML1277 Pyruvate kinase (EC 2.7.1.40) 472 0.19217 non-essential 0.19092 non-essential high NA high_confidence_nonessential NP_216133.1 90.9 0.07264 57.353 Moderate candidate ESM-2 calibrated P(essential)=0.192; HANSEN integrated essentiality score=0.191; ProteomeLM contextual percentile=0.073; target-priority score=57.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 614 ML0011 Q9CDE9 ppiA ML0011 Probable peptidyl-prolyl cis-trans isomerase A (PPIase A) (EC 5.2.1.8) (Rotamase A) 182 0.01019 non-essential 0.19087 non-essential high NA high_confidence_nonessential NP_214523.1 90.1 0.83845 80.78 High-priority ESM-2 calibrated P(essential)=0.010; HANSEN integrated essentiality score=0.191; ProteomeLM contextual percentile=0.838; target-priority score=80.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 615 ML1005 Q49844 nrdR ML1005 B2235_C2_209 u2235a Transcriptional repressor NrdR 154 0.09327 non-essential 0.19069 non-essential high NA high_confidence_nonessential NP_217234.1 92.7 0.50532 64.076 Moderate candidate ESM-2 calibrated P(essential)=0.093; HANSEN integrated essentiality score=0.191; ProteomeLM contextual percentile=0.505; target-priority score=64.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 616 ML1245 Q7AQ81 ML1245 Possible transferase 579 0.09928 non-essential 0.19062 non-essential high NA high_confidence_nonessential NP_216999.1 83.3 0.48654 60.944 Moderate candidate ESM-2 calibrated P(essential)=0.099; HANSEN integrated essentiality score=0.191; ProteomeLM contextual percentile=0.487; target-priority score=60.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 617 ML1309 Q49786 hisE ML1309 B2126_C2_204 MLCB2533.06 Phosphoribosyl-ATP pyrophosphatase (PRA-PH) (EC 3.6.1.31) 93 0.02795 non-essential 0.19062 non-essential high NA high_confidence_nonessential YP_177860.1 87.1 0.75767 80.021 High-priority ESM-2 calibrated P(essential)=0.028; HANSEN integrated essentiality score=0.191; ProteomeLM contextual percentile=0.758; target-priority score=80.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 618 ML0699 Q9CCM0 sdhC ML0699 Succinate dehydrogenase cytochrome B-556 subunit 153 0.02862 non-essential 0.1906 non-essential high NA high_confidence_nonessential NP_217833.1 88.4 0.78209 70.628 Strong candidate ESM-2 calibrated P(essential)=0.029; HANSEN integrated essentiality score=0.191; ProteomeLM contextual percentile=0.782; target-priority score=70.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 619 ML0025 Q9CDE1 ML0025 Uncharacterized protein 96 0.0 non-essential 0.19053 non-essential high NA high_confidence_nonessential 0.91735 69.158 Strong candidate ESM-2 calibrated P(essential)=0.000; HANSEN integrated essentiality score=0.191; ProteomeLM contextual percentile=0.917; target-priority score=69.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 620 ML0363 Q9CCV7 ML0363 ESAT-6-like protein 104 0.0 non-essential 0.19045 non-essential high NA high_confidence_nonessential NP_217961.1 71.2 0.91547 69.642 Strong candidate ESM-2 calibrated P(essential)=0.000; HANSEN integrated essentiality score=0.190; ProteomeLM contextual percentile=0.915; target-priority score=69.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 621 ML0308 Q7AQJ8 ML0308 Methyltransferase type 11 domain-containing protein 234 0.03604 non-essential 0.19006 non-essential high NA high_confidence_nonessential 0.74577 70.331 Strong candidate ESM-2 calibrated P(essential)=0.036; HANSEN integrated essentiality score=0.190; ProteomeLM contextual percentile=0.746; target-priority score=70.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 622 ML2295 Q9CB98 ML2295 Protease 234 0.0587 non-essential 0.19005 non-essential high NA high_confidence_nonessential NP_218185.1 77.1 0.65247 66.691 Strong candidate ESM-2 calibrated P(essential)=0.059; HANSEN integrated essentiality score=0.190; ProteomeLM contextual percentile=0.652; target-priority score=66.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 623 ML0562 Q9CCP1 uvrC ML0562 UvrABC system protein C (Protein UvrC) (Excinuclease ABC subunit C) 647 0.19217 non-essential 0.18976 non-essential high NA high_confidence_nonessential NP_215936.1 87.9 0.09831 46.303 Exploratory ESM-2 calibrated P(essential)=0.192; HANSEN integrated essentiality score=0.190; ProteomeLM contextual percentile=0.098; target-priority score=46.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 624 ML2496 P19993 dnaK ML2496 Chaperone protein DnaK (70 kDa antigen) (HSP70) (Heat shock 70 kDa protein) (Heat shock protein 70) 620 0.20204 non-essential 0.1897 non-essential medium NA high_confidence_nonessential NP_214864.1 90.1 0.05573 45.279 Exploratory ESM-2 calibrated P(essential)=0.202; HANSEN integrated essentiality score=0.190; ProteomeLM contextual percentile=0.056; target-priority score=45.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 625 ML1382 P46836 rpsA ML1382 Small ribosomal subunit protein bS1 (30S ribosomal protein S1) 481 0.19217 non-essential 0.18967 non-essential high NA high_confidence_nonessential NP_216146.1 93.8 0.09205 48.26 Exploratory ESM-2 calibrated P(essential)=0.192; HANSEN integrated essentiality score=0.190; ProteomeLM contextual percentile=0.092; target-priority score=48.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 626 ML1334 Q7AQ65 ML1334 Possible conserved membrane protein 272 0.02518 non-essential 0.18957 non-essential high NA high_confidence_nonessential NP_216607.1 58.8 0.80589 65.869 Strong candidate ESM-2 calibrated P(essential)=0.025; HANSEN integrated essentiality score=0.190; ProteomeLM contextual percentile=0.806; target-priority score=65.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 627 ML1813 Q9CBL4 ML1813 Uncharacterized protein 190 0.09928 non-essential 0.18954 non-essential high NA high_confidence_nonessential NP_215992.1 78.7 0.48779 58.363 Moderate candidate ESM-2 calibrated P(essential)=0.099; HANSEN integrated essentiality score=0.190; ProteomeLM contextual percentile=0.488; target-priority score=58.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 628 ML2354 Q9CB70 ML2354 Polyketide synthase 1822 0.03949 non-essential 0.18945 non-essential high NA high_confidence_nonessential NP_217450.1 80.3 0.7226 71.607 Strong candidate ESM-2 calibrated P(essential)=0.039; HANSEN integrated essentiality score=0.189; ProteomeLM contextual percentile=0.723; target-priority score=71.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:45Z 629 ML1105 Q9CC91 udgB ML1105 Type-5 uracil-DNA glycosylase (EC 3.2.2.-) 229 0.06371 non-essential 0.18931 non-essential high NA high_confidence_nonessential NP_215775.1 85.5 0.60676 72.927 Strong candidate ESM-2 calibrated P(essential)=0.064; HANSEN integrated essentiality score=0.189; ProteomeLM contextual percentile=0.607; target-priority score=72.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 630 ML0072 P13367 sodA ML0072 Superoxide dismutase [Mn] (EC 1.15.1.1) 207 0.05933 non-essential 0.18913 non-essential high NA high_confidence_nonessential NP_218363.1 80.6 0.61741 75.774 Strong candidate ESM-2 calibrated P(essential)=0.059; HANSEN integrated essentiality score=0.189; ProteomeLM contextual percentile=0.617; target-priority score=75.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 631 ML0285 Q7AQK2 ML0285 Membrane protein 292 0.02734 non-essential 0.18909 non-essential high NA high_confidence_nonessential NP_214875.1 61.6 0.79148 66.422 Strong candidate ESM-2 calibrated P(essential)=0.027; HANSEN integrated essentiality score=0.189; ProteomeLM contextual percentile=0.791; target-priority score=66.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 632 ML0410 Q49724 ML0410 PE-family protein 100 0.0 non-essential 0.18895 non-essential high NA high_confidence_nonessential 0.89793 72.606 Strong candidate ESM-2 calibrated P(essential)=0.000; HANSEN integrated essentiality score=0.189; ProteomeLM contextual percentile=0.898; target-priority score=72.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 633 ML2313 Q9CB82 ML2313 Transcription regulator PadR N-terminal domain-containing protein 200 0.01709 non-essential 0.18892 non-essential high NA high_confidence_nonessential 0.82718 69.936 Strong candidate ESM-2 calibrated P(essential)=0.017; HANSEN integrated essentiality score=0.189; ProteomeLM contextual percentile=0.827; target-priority score=69.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 634 ML1946 Q9CBH9 glpX ML1946 Fructose-1,6-bisphosphatase class 2 (FBPase class 2) (EC 3.1.3.11) (D-fructose-1,6-bisphosphate 1-phosphohydrolase class 2) 355 0.1873 non-essential 0.18881 non-essential high NA high_confidence_nonessential NP_215615.3 89.0 0.07639 59.465 Moderate candidate ESM-2 calibrated P(essential)=0.187; HANSEN integrated essentiality score=0.189; ProteomeLM contextual percentile=0.076; target-priority score=59.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 635 ML2661 Q9CCY8 ML2661 Acyl-CoA synthase 548 0.06907 non-essential 0.18872 non-essential high NA high_confidence_nonessential NP_214633.1 71.3 0.59862 66.152 Strong candidate ESM-2 calibrated P(essential)=0.069; HANSEN integrated essentiality score=0.189; ProteomeLM contextual percentile=0.599; target-priority score=66.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 636 ML0203 Q7AQM1 ML0203 Membrane protein 569 0.01233 non-essential 0.18872 non-essential high NA high_confidence_nonessential NP_218152.1 77.0 0.84095 72.291 Strong candidate ESM-2 calibrated P(essential)=0.012; HANSEN integrated essentiality score=0.189; ProteomeLM contextual percentile=0.841; target-priority score=72.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 637 ML0521 Q9CCS1 pepQ ML0521 Cytoplasmic peptidase 376 0.07497 non-essential 0.18847 non-essential high NA high_confidence_nonessential NP_217051.1 83.0 0.5742 64.753 Moderate candidate ESM-2 calibrated P(essential)=0.075; HANSEN integrated essentiality score=0.188; ProteomeLM contextual percentile=0.574; target-priority score=64.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 638 ML1544 Q7AQ46 ML1544 Conserved membrane protein 506 0.13353 non-essential 0.18828 non-essential high NA high_confidence_nonessential NP_216298.1 82.8 0.32999 56.061 Moderate candidate ESM-2 calibrated P(essential)=0.134; HANSEN integrated essentiality score=0.188; ProteomeLM contextual percentile=0.330; target-priority score=56.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 639 ML0591 Q7AQH7 ML0591 Membrane protein 593 0.08711 non-essential 0.18824 non-essential high NA high_confidence_nonessential NP_215975.1 74.7 0.52223 63.036 Moderate candidate ESM-2 calibrated P(essential)=0.087; HANSEN integrated essentiality score=0.188; ProteomeLM contextual percentile=0.522; target-priority score=63.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 640 ML0538 Q9CCR0 PE ML0538 PE-family protein 102 0.0 non-essential 0.18818 non-essential high NA high_confidence_nonessential YP_177805.1 72.5 0.89543 71.909 Strong candidate ESM-2 calibrated P(essential)=0.000; HANSEN integrated essentiality score=0.188; ProteomeLM contextual percentile=0.895; target-priority score=71.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 641 ML1615 O33017 trmD ML1615 MLCB250.35 tRNA (guanine-N(1)-)-methyltransferase (EC 2.1.1.228) (M1G-methyltransferase) (tRNA [GM37] methyltransferase) 238 0.04041 non-essential 0.18815 non-essential high NA high_confidence_nonessential NP_217422.1 87.7 0.69255 77.795 Strong candidate ESM-2 calibrated P(essential)=0.040; HANSEN integrated essentiality score=0.188; ProteomeLM contextual percentile=0.693; target-priority score=77.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 642 ML0062 Q9CDD4 gltD ML0062 NADH-dependent glutamate synthase small subunit (EC 1.4.1.13) 488 0.14132 non-essential 0.18798 non-essential high NA high_confidence_nonessential NP_218375.1 87.7 0.27239 62.895 Moderate candidate ESM-2 calibrated P(essential)=0.141; HANSEN integrated essentiality score=0.188; ProteomeLM contextual percentile=0.272; target-priority score=62.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 643 ML2151 Q7APY1 ML2151 Resuscitation-promoting factor RpfA 174 0.00198 non-essential 0.18765 non-essential high NA high_confidence_nonessential NP_215382.1 72.0 0.87915 73.309 Strong candidate ESM-2 calibrated P(essential)=0.002; HANSEN integrated essentiality score=0.188; ProteomeLM contextual percentile=0.879; target-priority score=73.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 644 ML2111 Q50121 ML2111 Transmembrane protein 144 0.06278 non-essential 0.18762 non-essential high NA high_confidence_nonessential NP_215427.1 67.4 0.62617 64.394 Moderate candidate ESM-2 calibrated P(essential)=0.063; HANSEN integrated essentiality score=0.188; ProteomeLM contextual percentile=0.626; target-priority score=64.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 645 ML0990 Q7AQB8 ML0990 Possible conserved membrane protein 209 0.06543 non-essential 0.18755 non-essential high NA high_confidence_nonessential NP_217248.1 73.3 0.61929 62.461 Moderate candidate ESM-2 calibrated P(essential)=0.065; HANSEN integrated essentiality score=0.188; ProteomeLM contextual percentile=0.619; target-priority score=62.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 646 ML0466 Q7AQI8 ML0466 Possible secreted protein 301 0.07755 non-essential 0.18751 non-essential high NA high_confidence_nonessential 0.56857 60.733 Moderate candidate ESM-2 calibrated P(essential)=0.078; HANSEN integrated essentiality score=0.188; ProteomeLM contextual percentile=0.569; target-priority score=60.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 647 ML0664 Q9CCM5 ML0664 Uncharacterized protein 87 0.00543 non-essential 0.18745 non-essential high NA high_confidence_nonessential 0.87539 68.795 Strong candidate ESM-2 calibrated P(essential)=0.005; HANSEN integrated essentiality score=0.187; ProteomeLM contextual percentile=0.875; target-priority score=68.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 648 ML0064 Q9CDD3 ML0064 Transcriptional regulator 214 0.0332 non-essential 0.18735 non-essential high NA high_confidence_nonessential NP_218372.1 76.4 0.74139 70.831 Strong candidate ESM-2 calibrated P(essential)=0.033; HANSEN integrated essentiality score=0.187; ProteomeLM contextual percentile=0.741; target-priority score=70.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 649 ML0514 Q9CCS8 mltG ML0514 Endolytic murein transglycosylase (EC 4.2.2.29) (Peptidoglycan lytic transglycosylase) (Peptidoglycan polymerization terminase) 421 0.07502 non-essential 0.18733 non-essential high NA high_confidence_nonessential NP_217069.1 69.8 0.5454 72.182 Strong candidate ESM-2 calibrated P(essential)=0.075; HANSEN integrated essentiality score=0.187; ProteomeLM contextual percentile=0.545; target-priority score=72.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 650 ML0848 Q9CCF9 ML0848 ABC transporter 724 0.0723 non-essential 0.18725 non-essential high NA high_confidence_nonessential NP_216842.1 77.3 0.58547 62.649 Moderate candidate ESM-2 calibrated P(essential)=0.072; HANSEN integrated essentiality score=0.187; ProteomeLM contextual percentile=0.585; target-priority score=62.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 651 ML1258 Q9X7B8 hisC ML1258 MLCB1610.21 Histidinol-phosphate aminotransferase (EC 2.6.1.9) (Imidazole acetol-phosphate transaminase) 377 0.19217 non-essential 0.18712 non-essential high NA high_confidence_nonessential YP_177823.1 83.6 0.05322 56.356 Moderate candidate ESM-2 calibrated P(essential)=0.192; HANSEN integrated essentiality score=0.187; ProteomeLM contextual percentile=0.053; target-priority score=56.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 652 ML0590 Q7AQH8 ML0590 ABC transporter ATP-binding protein 315 0.09598 non-essential 0.18703 non-essential high NA high_confidence_nonessential NP_215974.1 88.0 0.48153 60.599 Moderate candidate ESM-2 calibrated P(essential)=0.096; HANSEN integrated essentiality score=0.187; ProteomeLM contextual percentile=0.482; target-priority score=60.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 653 ML1997 Q9CBG1 ML1997 Probable integral membrane protein 210 0.00216 non-essential 0.18682 non-essential high NA high_confidence_nonessential NP_215485.1 51.4 0.88291 70.074 Strong candidate ESM-2 calibrated P(essential)=0.002; HANSEN integrated essentiality score=0.187; ProteomeLM contextual percentile=0.883; target-priority score=70.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 654 ML0541 Q9CCQ7 gmk ML0541 Guanylate kinase (EC 2.7.4.8) (GMP kinase) 210 0.02913 non-essential 0.18678 non-essential high NA high_confidence_nonessential NP_215905.1 77.3 0.73388 78.597 Strong candidate ESM-2 calibrated P(essential)=0.029; HANSEN integrated essentiality score=0.187; ProteomeLM contextual percentile=0.734; target-priority score=78.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 655 ML1664 Q9CBS5 ML1664 Methyltransferase 157 0.01553 non-essential 0.18675 non-essential high NA high_confidence_nonessential NP_217482.1 72.3 0.80839 74.423 Strong candidate ESM-2 calibrated P(essential)=0.016; HANSEN integrated essentiality score=0.187; ProteomeLM contextual percentile=0.808; target-priority score=74.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 656 ML1799 Q9CBM7 mutB ML1799 Probable methylmalonyl-CoA mutase large subunit (EC 5.4.99.2) 758 0.10418 non-essential 0.18659 non-essential high NA high_confidence_nonessential NP_216009.1 88.9 0.42705 65.466 Strong candidate ESM-2 calibrated P(essential)=0.104; HANSEN integrated essentiality score=0.187; ProteomeLM contextual percentile=0.427; target-priority score=65.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 657 ML0395 P46810 guaA ML0395 B1620_C2_205 GMP synthase [glutamine-hydrolyzing] (EC 6.3.5.2) (GMP synthetase) (Glutamine amidotransferase) 529 0.12033 non-essential 0.1864 non-essential high NA high_confidence_nonessential NP_217913.1 86.4 0.34377 68.209 Strong candidate ESM-2 calibrated P(essential)=0.120; HANSEN integrated essentiality score=0.186; ProteomeLM contextual percentile=0.344; target-priority score=68.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 658 ML2393 P46808 greA ML2393 Transcription elongation factor GreA (Transcript cleavage factor GreA) 164 0.0797 non-essential 0.18631 non-essential high NA high_confidence_nonessential NP_215596.1 94.5 0.54289 63.706 Moderate candidate ESM-2 calibrated P(essential)=0.080; HANSEN integrated essentiality score=0.186; ProteomeLM contextual percentile=0.543; target-priority score=63.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 659 ML2011 Q7AQ05 aao ML2011 D-amino-acid oxidase (EC 1.4.3.3) 320 0.04552 non-essential 0.18608 non-essential high NA high_confidence_nonessential NP_216421.1 71.4 0.65999 76.751 Strong candidate ESM-2 calibrated P(essential)=0.046; HANSEN integrated essentiality score=0.186; ProteomeLM contextual percentile=0.660; target-priority score=76.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 660 ML0925 Q9CCD8 glnA ML0925 Glutamine synthetase (EC 6.3.1.2) 478 0.06628 non-essential 0.18598 non-essential high NA high_confidence_nonessential NP_216736.1 92.1 0.57295 73.767 Strong candidate ESM-2 calibrated P(essential)=0.066; HANSEN integrated essentiality score=0.186; ProteomeLM contextual percentile=0.573; target-priority score=73.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 661 ML0271 Q9CCX5 ML0271 Membrane protein 123 0.00198 non-essential 0.18594 non-essential high NA high_confidence_nonessential NP_214915.1 66.9 0.87101 72.657 Strong candidate ESM-2 calibrated P(essential)=0.002; HANSEN integrated essentiality score=0.186; ProteomeLM contextual percentile=0.871; target-priority score=72.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 662 ML1093 Q9CC99 ML1093 Lipoprotein 285 0.0949 non-essential 0.18575 non-essential high NA high_confidence_nonessential NP_215760.1 73.5 0.4784 60.799 Moderate candidate ESM-2 calibrated P(essential)=0.095; HANSEN integrated essentiality score=0.186; ProteomeLM contextual percentile=0.478; target-priority score=60.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 663 ML1229 Q49624 pks3 ML1229 Mycocerosic acid synthase (Polyketide synthase) 2118 0.03604 non-essential 0.18566 non-essential high NA high_confidence_nonessential NP_216043.1 64.8 0.71634 71.537 Strong candidate ESM-2 calibrated P(essential)=0.036; HANSEN integrated essentiality score=0.186; ProteomeLM contextual percentile=0.716; target-priority score=71.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:45Z 664 ML1600 Q9CBU0 xerC ML1600 MLCB250.62 Tyrosine recombinase XerC 297 0.07281 non-essential 0.18558 non-essential high NA high_confidence_nonessential NP_217410.1 85.1 0.5623 66.379 Strong candidate ESM-2 calibrated P(essential)=0.073; HANSEN integrated essentiality score=0.186; ProteomeLM contextual percentile=0.562; target-priority score=66.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 665 ML1905 Q9CBK1 rplK ML1905 Large ribosomal subunit protein uL11 (50S ribosomal protein L11) 142 0.09152 non-essential 0.18557 non-essential high NA high_confidence_nonessential NP_215154.1 92.3 0.48591 63.154 Moderate candidate ESM-2 calibrated P(essential)=0.092; HANSEN integrated essentiality score=0.186; ProteomeLM contextual percentile=0.486; target-priority score=63.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 666 ML2532 Q9CD32 ML2532 PE-family protein 98 0.0 non-essential 0.18537 non-essential high NA high_confidence_nonessential NP_214801.1 77.9 0.87977 71.614 Strong candidate ESM-2 calibrated P(essential)=0.000; HANSEN integrated essentiality score=0.185; ProteomeLM contextual percentile=0.880; target-priority score=71.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 667 ML0771 Q9CCJ4 ahcY sahH ML0771 Adenosylhomocysteinase (EC 3.13.2.1) (S-adenosyl-L-homocysteine hydrolase) (AdoHcyase) 492 0.19217 non-essential 0.18526 non-essential high NA high_confidence_nonessential NP_217765.1 91.4 0.03381 59.228 Moderate candidate ESM-2 calibrated P(essential)=0.192; HANSEN integrated essentiality score=0.185; ProteomeLM contextual percentile=0.034; target-priority score=59.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 668 ML1966 Q7AQ09 lpqH ML1966 Possible lipoprotein 161 0.00674 non-essential 0.18515 non-essential high NA high_confidence_nonessential 0.84721 71.735 Strong candidate ESM-2 calibrated P(essential)=0.007; HANSEN integrated essentiality score=0.185; ProteomeLM contextual percentile=0.847; target-priority score=71.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 669 ML1182 Q7AQ89 ML1182 PPE-family protein 421 0.0 non-essential 0.18508 non-essential high NA high_confidence_nonessential YP_177801.1 39.9 0.8804 70.825 Strong candidate ESM-2 calibrated P(essential)=0.000; HANSEN integrated essentiality score=0.185; ProteomeLM contextual percentile=0.880; target-priority score=70.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 670 ML0671 O32881 smpB ML0671 MLCB1779.19c SsrA-binding protein (Small protein B) 160 0.07314 non-essential 0.18491 non-essential high NA high_confidence_nonessential NP_217616.1 85.5 0.56105 64.959 Moderate candidate ESM-2 calibrated P(essential)=0.073; HANSEN integrated essentiality score=0.185; ProteomeLM contextual percentile=0.561; target-priority score=65.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 671 ML0406 Q49723 ML0406 B1620_C2_214 MLCL383.02 EspC protein homolog 106 0.0 non-essential 0.18491 non-essential high NA high_confidence_nonessential 0.87477 72.409 Strong candidate ESM-2 calibrated P(essential)=0.000; HANSEN integrated essentiality score=0.185; ProteomeLM contextual percentile=0.875; target-priority score=72.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 672 ML0365 P40828 rpsI ML0365 B229_C2_191 Small ribosomal subunit protein uS9 (30S ribosomal protein S9) 153 0.1873 non-essential 0.1849 non-essential high NA high_confidence_nonessential NP_217959.1 83.9 0.08641 48.232 Exploratory ESM-2 calibrated P(essential)=0.187; HANSEN integrated essentiality score=0.185; ProteomeLM contextual percentile=0.086; target-priority score=48.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 673 ML1932 Q9CBI1 ML1932 Transmembrane protein 137 0.01019 non-essential 0.1849 non-essential high NA high_confidence_nonessential NP_214940.1 69.0 0.8422 67.554 Strong candidate ESM-2 calibrated P(essential)=0.010; HANSEN integrated essentiality score=0.185; ProteomeLM contextual percentile=0.842; target-priority score=67.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 674 ML1411 P57992 argR ML1411 Arginine repressor 167 0.14132 non-essential 0.18483 non-essential high NA high_confidence_nonessential NP_216173.1 81.6 0.27301 56.386 Moderate candidate ESM-2 calibrated P(essential)=0.141; HANSEN integrated essentiality score=0.185; ProteomeLM contextual percentile=0.273; target-priority score=56.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 675 ML0520 Q9CCS2 ML0520 Membrane protein 202 0.02518 non-essential 0.18472 non-essential high NA high_confidence_nonessential NP_217052.1 48.7 0.77145 67.865 Strong candidate ESM-2 calibrated P(essential)=0.025; HANSEN integrated essentiality score=0.185; ProteomeLM contextual percentile=0.771; target-priority score=67.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 676 ML0845 Q7AQF1 ML0845 Acyl-CoA oxidase C-terminal domain-containing protein 193 0.00543 non-essential 0.1847 non-essential high NA high_confidence_nonessential 0.8541 70.544 Strong candidate ESM-2 calibrated P(essential)=0.005; HANSEN integrated essentiality score=0.185; ProteomeLM contextual percentile=0.854; target-priority score=70.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 677 ML0114 Q9CDA0 ML0114 ABC transporter ATP-binding component 272 0.14132 non-essential 0.18455 non-essential high NA high_confidence_nonessential NP_218298.1 91.4 0.2799 53.476 Moderate candidate ESM-2 calibrated P(essential)=0.141; HANSEN integrated essentiality score=0.185; ProteomeLM contextual percentile=0.280; target-priority score=53.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 678 ML0405 Q49722 ML0405 ESX-1 secretion-associated protein EspA/EspE-like domain-containing protein 394 0.00198 non-essential 0.18441 non-essential high NA high_confidence_nonessential NP_218133.1 61.7 0.87289 68.957 Strong candidate ESM-2 calibrated P(essential)=0.002; HANSEN integrated essentiality score=0.184; ProteomeLM contextual percentile=0.873; target-priority score=69.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 679 ML1828 Q7AQ23 PPE ML1828 PPE-family protein 572 0.00198 non-essential 0.1842 non-essential high NA high_confidence_nonessential YP_177704.1 58.6 0.86788 70.236 Strong candidate ESM-2 calibrated P(essential)=0.002; HANSEN integrated essentiality score=0.184; ProteomeLM contextual percentile=0.868; target-priority score=70.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 680 ML2622 Q9CCZ9 trmB ML2622 MLCL622.20c tRNA (guanine-N(7)-)-methyltransferase (EC 2.1.1.33) (tRNA (guanine(46)-N(7))-methyltransferase) (tRNA(m7G46)-methyltransferase) 230 0.05758 non-essential 0.18415 non-essential high NA high_confidence_nonessential NP_214722.1 67.1 0.59173 77.29 Strong candidate ESM-2 calibrated P(essential)=0.058; HANSEN integrated essentiality score=0.184; ProteomeLM contextual percentile=0.592; target-priority score=77.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 681 ML2422 P46724 hemA ML2422 B2168_C3_261 Glutamyl-tRNA reductase (GluTR) (EC 1.2.1.70) 467 0.10418 non-essential 0.18407 non-essential high NA high_confidence_nonessential NP_215023.1 82.5 0.39825 70.217 Strong candidate ESM-2 calibrated P(essential)=0.104; HANSEN integrated essentiality score=0.184; ProteomeLM contextual percentile=0.398; target-priority score=70.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 682 ML0425 Q9CCU6 ML0425 Membrane protein 75 0.03847 non-essential 0.18389 non-essential high NA high_confidence_nonessential NP_217036.1 58.7 0.71384 65.066 Strong candidate ESM-2 calibrated P(essential)=0.038; HANSEN integrated essentiality score=0.184; ProteomeLM contextual percentile=0.714; target-priority score=65.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 683 ML0902 Q7AQC9 ML0902 Probable lipoprotein 239 0.07065 non-essential 0.18388 non-essential high NA high_confidence_nonessential NP_216687.1 76.4 0.57858 60.835 Moderate candidate ESM-2 calibrated P(essential)=0.071; HANSEN integrated essentiality score=0.184; ProteomeLM contextual percentile=0.579; target-priority score=60.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 684 ML1053 Q7AQ88 ML1053 ML1183 PE domain-containing protein 99 0.0 non-essential 0.18387 non-essential high NA high_confidence_nonessential YP_177975.1 47.3 0.87038 71.819 Strong candidate ESM-2 calibrated P(essential)=0.000; HANSEN integrated essentiality score=0.184; ProteomeLM contextual percentile=0.870; target-priority score=71.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 685 ML0539 Q9CCQ9 PPE ML0539 PPE-family protein 538 0.01307 non-essential 0.18377 non-essential high NA high_confidence_nonessential YP_177806.1 66.1 0.81841 68.9 Strong candidate ESM-2 calibrated P(essential)=0.013; HANSEN integrated essentiality score=0.184; ProteomeLM contextual percentile=0.818; target-priority score=68.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 686 ML0275 Q9CCX4 metZ ML0275 O-succinylhomoserine sulfhydrylase (OSH sulfhydrylase) (OSHS sulfhydrylase) (EC 2.5.1.-) 406 0.14132 non-essential 0.18358 non-essential high NA high_confidence_nonessential NP_214905.1 87.9 0.24483 63.454 Moderate candidate ESM-2 calibrated P(essential)=0.141; HANSEN integrated essentiality score=0.184; ProteomeLM contextual percentile=0.245; target-priority score=63.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 687 ML1132 P45835 rho ML1132 Transcription termination factor Rho (EC 3.6.4.-) (ATP-dependent helicase Rho) 610 0.19217 non-essential 0.18342 non-essential high NA high_confidence_nonessential NP_215813.1 80.5 0.04759 50.865 Moderate candidate ESM-2 calibrated P(essential)=0.192; HANSEN integrated essentiality score=0.183; ProteomeLM contextual percentile=0.048; target-priority score=50.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 688 ML0859 O32961 lipB ML0859 MLCB22.19 Octanoyltransferase (EC 2.3.1.181) (Lipoate-protein ligase B) (Lipoyl/octanoyl transferase) (Octanoyl-[acyl-carrier-protein]-protein N-octanoyltransferase) 235 0.03424 non-essential 0.18338 non-essential high NA high_confidence_nonessential NP_216733.1 78.4 0.68441 80.641 High-priority ESM-2 calibrated P(essential)=0.034; HANSEN integrated essentiality score=0.183; ProteomeLM contextual percentile=0.684; target-priority score=80.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 689 ML0626 Q9CCN1 ML0626 Ribosomal RNA small subunit methyltransferase E (EC 2.1.1.193) 257 0.04818 non-essential 0.18324 non-essential high NA high_confidence_nonessential NP_216888.1 77.3 0.63745 74.589 Strong candidate ESM-2 calibrated P(essential)=0.048; HANSEN integrated essentiality score=0.183; ProteomeLM contextual percentile=0.637; target-priority score=74.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 690 ML2357 Q7APV8 ML2357 Polyketide synthase 1871 0.01648 non-essential 0.18322 non-essential high NA high_confidence_nonessential NP_217447.1 75.3 0.79211 71.423 Strong candidate ESM-2 calibrated P(essential)=0.016; HANSEN integrated essentiality score=0.183; ProteomeLM contextual percentile=0.792; target-priority score=71.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:45Z 691 ML0698 Q7AQF8 sdhD ML0698 Succinate dehydrogenase hydrophobic membrane anchor protei 163 0.0949 non-essential 0.18319 non-essential high NA high_confidence_nonessential NP_217834.1 85.2 0.46775 59.3 Moderate candidate ESM-2 calibrated P(essential)=0.095; HANSEN integrated essentiality score=0.183; ProteomeLM contextual percentile=0.468; target-priority score=59.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 692 ML2278 Q9CBA4 htpX ML2278 Protease HtpX homolog (EC 3.4.24.-) 287 0.05936 non-essential 0.18297 non-essential high NA high_confidence_nonessential NP_215077.1 88.5 0.59549 70.877 Strong candidate ESM-2 calibrated P(essential)=0.059; HANSEN integrated essentiality score=0.183; ProteomeLM contextual percentile=0.595; target-priority score=70.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 693 ML1761 Q9CBP0 ML1761 Uncharacterized protein 114 0.02389 non-essential 0.18278 non-essential high NA high_confidence_nonessential 0.77332 65.351 Strong candidate ESM-2 calibrated P(essential)=0.024; HANSEN integrated essentiality score=0.183; ProteomeLM contextual percentile=0.773; target-priority score=65.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 694 ML0214 O69537 hpt hprT ML0214 Hypoxanthine-guanine phosphoribosyltransferase (HGPRT) (HGPRTase) (EC 2.4.2.8) 203 0.13339 non-essential 0.18269 non-essential high NA high_confidence_nonessential NP_218141.1 83.5 0.26925 65.747 Strong candidate ESM-2 calibrated P(essential)=0.133; HANSEN integrated essentiality score=0.183; ProteomeLM contextual percentile=0.269; target-priority score=65.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 695 ML1115 Q9CC87 lprB ML1115 Putative lipoprotein LprB 188 0.00198 non-essential 0.18266 non-essential high NA high_confidence_nonessential NP_215790.1 78.7 0.8516 72.69 Strong candidate ESM-2 calibrated P(essential)=0.002; HANSEN integrated essentiality score=0.183; ProteomeLM contextual percentile=0.852; target-priority score=72.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 696 ML0051 Q7AQP1 ML0051 PPE-family protein 302 0.00198 non-essential 0.18263 non-essential high NA high_confidence_nonessential YP_178022.1 46.2 0.86537 67.942 Strong candidate ESM-2 calibrated P(essential)=0.002; HANSEN integrated essentiality score=0.183; ProteomeLM contextual percentile=0.865; target-priority score=67.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 697 ML0411 Q07297 sra ML0411 MLCL383.14 Serine-rich antigen (25L) (45 kDa protein) 408 0.0 non-essential 0.1826 non-essential high NA high_confidence_nonessential 0.866 70.767 Strong candidate ESM-2 calibrated P(essential)=0.000; HANSEN integrated essentiality score=0.183; ProteomeLM contextual percentile=0.866; target-priority score=70.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 698 ML2529 Q9CD35 ML2529 Conserved membrane protein 485 0.03769 non-essential 0.18245 non-essential high NA high_confidence_nonessential NP_214804.1 76.0 0.70257 67.233 Strong candidate ESM-2 calibrated P(essential)=0.038; HANSEN integrated essentiality score=0.182; ProteomeLM contextual percentile=0.703; target-priority score=67.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 699 ML0224 P0C0X1 folP1 folP ML0224 MLCB2548.07c Dihydropteroate synthase (DHPS) (EC 2.5.1.15) (Dihydropteroate pyrophosphorylase) 284 0.04818 non-essential 0.18235 non-essential high NA high_confidence_nonessential YP_177997.1 77.1 0.61616 80.062 High-priority ESM-2 calibrated P(essential)=0.048; HANSEN integrated essentiality score=0.182; ProteomeLM contextual percentile=0.616; target-priority score=80.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 700 ML0904 Q7AQC7 ML0904 Probable membrane protein 134 0.10418 non-essential 0.18228 non-essential high NA high_confidence_nonessential NP_216685.1 86.6 0.43582 53.865 Moderate candidate ESM-2 calibrated P(essential)=0.104; HANSEN integrated essentiality score=0.182; ProteomeLM contextual percentile=0.436; target-priority score=53.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 701 ML2546 Q9CD27 fadD2 ML2546 Long-chain-fatty-acid--CoA ligase FadD13 (EC 6.2.1.3) (Fatty acyl-CoA ligase) (Fatty acyl-CoA synthetase) (Very-long-chain fatty-acyl-CoA synthetase) 548 0.14132 non-essential 0.18225 non-essential high NA high_confidence_nonessential NP_214784.1 83.4 0.24796 59.735 Moderate candidate ESM-2 calibrated P(essential)=0.141; HANSEN integrated essentiality score=0.182; ProteomeLM contextual percentile=0.248; target-priority score=59.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 702 ML2634 Q9CCZ8 pntB ML2634 NAD(P) transhydrogenase subunit beta (EC 7.1.1.1) (Nicotinamide nucleotide transhydrogenase subunit beta) 472 0.08714 non-essential 0.18172 non-essential high NA high_confidence_nonessential NP_214671.1 83.1 0.47026 67.608 Strong candidate ESM-2 calibrated P(essential)=0.087; HANSEN integrated essentiality score=0.182; ProteomeLM contextual percentile=0.470; target-priority score=67.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 703 ML0226 O69528 folK ML0226 MLCB2548.05c 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase (EC 2.7.6.3) (6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase) (PPPK) (7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase) (HPPK) 191 0.02338 non-essential 0.1817 non-essential high NA high_confidence_nonessential NP_218123.1 65.3 0.72323 81.034 High-priority ESM-2 calibrated P(essential)=0.023; HANSEN integrated essentiality score=0.182; ProteomeLM contextual percentile=0.723; target-priority score=81.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 704 ML2531 Q9CD33 esxR ML2531 ESAT-6-like protein EsxR 96 0.0 non-essential 0.18167 non-essential high NA high_confidence_nonessential NP_214802.1 70.8 0.85598 72.308 Strong candidate ESM-2 calibrated P(essential)=0.000; HANSEN integrated essentiality score=0.182; ProteomeLM contextual percentile=0.856; target-priority score=72.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 705 ML0126 Q9CD90 ML0126 Biotin carboxyl carrier protein 273 0.02734 non-essential 0.18159 non-essential high NA high_confidence_nonessential 0.74202 68.236 Strong candidate ESM-2 calibrated P(essential)=0.027; HANSEN integrated essentiality score=0.182; ProteomeLM contextual percentile=0.742; target-priority score=68.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 706 ML1419 Q7AQ57 ML1419 Possible regulatory protein 563 0.02518 non-essential 0.18149 non-essential high NA high_confidence_nonessential 0.74765 69.501 Strong candidate ESM-2 calibrated P(essential)=0.025; HANSEN integrated essentiality score=0.181; ProteomeLM contextual percentile=0.748; target-priority score=69.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 707 ML1987 P46839 ctpA ML1987 Copper-exporting P-type ATPase (EC 7.2.2.8) (Copper-exporting P-type ATPase A) 780 0.00543 non-essential 0.18136 non-essential high NA high_confidence_nonessential NP_214606.1 76.5 0.80964 78.98 Strong candidate ESM-2 calibrated P(essential)=0.005; HANSEN integrated essentiality score=0.181; ProteomeLM contextual percentile=0.810; target-priority score=79.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:45Z 708 ML2587 Q9CD16 yrbE1A ML2587 Conserved membrane protein 267 0.00543 non-essential 0.18131 non-essential high NA high_confidence_nonessential NP_214681.1 88.0 0.82843 72.481 Strong candidate ESM-2 calibrated P(essential)=0.005; HANSEN integrated essentiality score=0.181; ProteomeLM contextual percentile=0.828; target-priority score=72.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 709 ML1536 Q9CBV5 ML1536 AAA+ ATPase domain-containing protein 610 0.08411 non-essential 0.18121 non-essential high NA high_confidence_nonessential NP_216314.1 89.8 0.49969 61.32 Moderate candidate ESM-2 calibrated P(essential)=0.084; HANSEN integrated essentiality score=0.181; ProteomeLM contextual percentile=0.500; target-priority score=61.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 710 ML0486 Q49647 yajC ML0486 B1177_C3_235 MLCB1259.04 Sec translocon accessory complex subunit YajC 114 0.01648 non-essential 0.18113 non-essential high NA high_confidence_nonessential NP_217104.1 65.9 0.78773 68.721 Strong candidate ESM-2 calibrated P(essential)=0.016; HANSEN integrated essentiality score=0.181; ProteomeLM contextual percentile=0.788; target-priority score=68.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 711 ML2054 Q9CBF0 ML2054 Integral membrane protein 99 0.01019 non-essential 0.18107 non-essential high NA high_confidence_nonessential NP_216377.1 58.4 0.81152 70.325 Strong candidate ESM-2 calibrated P(essential)=0.010; HANSEN integrated essentiality score=0.181; ProteomeLM contextual percentile=0.812; target-priority score=70.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 712 ML0310 Q9ZBM2 pssA ML0310 MLCB1450.12 CDP-diacylglycerol--serine O-phosphatidyltransferase (EC 2.7.8.8) (Phosphatidylserine synthase) 300 0.06116 non-essential 0.1805 non-essential high NA high_confidence_nonessential NP_214950.1 77.9 0.57671 69.515 Strong candidate ESM-2 calibrated P(essential)=0.061; HANSEN integrated essentiality score=0.181; ProteomeLM contextual percentile=0.577; target-priority score=69.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 713 ML0044 Q7AQP2 ML0044 ML0044 protein 113 0.01709 non-essential 0.18023 non-essential high NA high_confidence_nonessential NP_218397.1 55.6 0.77583 70.017 Strong candidate ESM-2 calibrated P(essential)=0.017; HANSEN integrated essentiality score=0.180; ProteomeLM contextual percentile=0.776; target-priority score=70.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 714 ML0021 Q7AQP5 ML0021 FHA domain-containing protein FhaB (FtsZ-interacting protein A) 155 0.0949 non-essential 0.18021 non-essential high NA high_confidence_nonessential NP_214533.1 91.0 0.44646 60.585 Moderate candidate ESM-2 calibrated P(essential)=0.095; HANSEN integrated essentiality score=0.180; ProteomeLM contextual percentile=0.446; target-priority score=60.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 715 ML1096 Q9CC96 ML1096 Membrane protein 224 0.03604 non-essential 0.1802 non-essential high NA high_confidence_nonessential NP_215765.1 66.8 0.70319 65.099 Strong candidate ESM-2 calibrated P(essential)=0.036; HANSEN integrated essentiality score=0.180; ProteomeLM contextual percentile=0.703; target-priority score=65.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 716 ML0030 O32871 ML0030 MLB1770.18c Uncharacterized protein ML0030 113 0.01648 non-essential 0.18 non-essential high NA high_confidence_nonessential NP_214553.1 63.2 0.78334 67.953 Strong candidate ESM-2 calibrated P(essential)=0.016; HANSEN integrated essentiality score=0.180; ProteomeLM contextual percentile=0.783; target-priority score=68.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 717 ML0380 P24301 groES chpA groS mopB ML0380 B1620_C3_227 B229_C3_247 Co-chaperonin GroES (10 kDa antigen) (10 kDa chaperonin) (Chaperonin-10) (Cpn10) 100 0.10794 non-essential 0.17997 non-essential high NA high_confidence_nonessential NP_217935.1 90.0 0.39887 55.921 Moderate candidate ESM-2 calibrated P(essential)=0.108; HANSEN integrated essentiality score=0.180; ProteomeLM contextual percentile=0.399; target-priority score=55.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 718 ML0825 Q9CCG5 ML0825 ArsR-family transcriptional regulator 140 0.03604 non-essential 0.17969 non-essential high NA high_confidence_nonessential NP_216874.1 72.9 0.69317 67.488 Strong candidate ESM-2 calibrated P(essential)=0.036; HANSEN integrated essentiality score=0.180; ProteomeLM contextual percentile=0.693; target-priority score=67.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 719 ML0491 Q49640 relA ML0491 B1177_C1_168 MLCB1259.09 Probable GTP pyrophosphokinase (EC 2.7.6.5) ((p)ppGpp synthase) (ATP:GTP 3'-pyrophosphotransferase) (ppGpp synthase I) 787 0.19217 non-essential 0.17955 non-essential high NA high_confidence_nonessential NP_217099.1 91.5 0.02129 52.064 Moderate candidate ESM-2 calibrated P(essential)=0.192; HANSEN integrated essentiality score=0.180; ProteomeLM contextual percentile=0.021; target-priority score=52.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:45Z 720 ML0986 Q9CCC1 ML0986 Signal transduction histidine kinase 67 0.09148 non-essential 0.17951 non-essential high agree high_confidence_nonessential Rv2738c 83.6 NE 0 0.87727 73.778 Strong candidate ESM-2 calibrated P(essential)=0.091; HANSEN integrated essentiality score=0.180; Mtb RBH anchor Rv2738c=non-essential (agree); ProteomeLM contextual percentile=0.877; target-priority score=73.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 721 ML2077 O32920 gcvH ML2077 MLCB1788.37c Glycine cleavage system H protein 132 0.00476 non-essential 0.17951 non-essential high NA high_confidence_nonessential NP_216342.1 79.1 0.81465 74.603 Strong candidate ESM-2 calibrated P(essential)=0.005; HANSEN integrated essentiality score=0.180; ProteomeLM contextual percentile=0.815; target-priority score=74.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 722 ML1469 Q9CBZ0 ndk ML1469 Nucleoside diphosphate kinase (NDK) (NDP kinase) (EC 2.7.4.6) (Nucleoside-2-P kinase) 136 0.06257 non-essential 0.17941 non-essential high NA high_confidence_nonessential NP_216961.1 88.1 0.55229 73.435 Strong candidate ESM-2 calibrated P(essential)=0.063; HANSEN integrated essentiality score=0.179; ProteomeLM contextual percentile=0.552; target-priority score=73.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 723 ML1310 Q49776 hisG ML1310 B2126_C1_162 MLCB2533.07 ATP phosphoribosyltransferase (ATP-PRT) (ATP-PRTase) (EC 2.4.2.17) 287 0.14132 non-essential 0.17937 non-essential high NA high_confidence_nonessential NP_216637.1 87.8 0.22354 62.272 Moderate candidate ESM-2 calibrated P(essential)=0.141; HANSEN integrated essentiality score=0.179; ProteomeLM contextual percentile=0.224; target-priority score=62.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 724 ML1655 Q9CBS7 kasA ML1655 MLCB1243.20c 3-oxoacyl-[acyl-carrier-protein] synthase 1 (EC 2.3.1.293) (Beta-ketoacyl-ACP synthase 1) (KAS 1) 416 0.06981 non-essential 0.17933 non-essential high NA high_confidence_nonessential NP_216761.1 92.8 0.50783 77.104 Strong candidate ESM-2 calibrated P(essential)=0.070; HANSEN integrated essentiality score=0.179; ProteomeLM contextual percentile=0.508; target-priority score=77.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 725 ML1539 Q9CBV2 ML1539 Probable membrane protein 503 0.04677 non-essential 0.17932 non-essential high NA high_confidence_nonessential NP_216311.1 69.2 0.64872 65.117 Strong candidate ESM-2 calibrated P(essential)=0.047; HANSEN integrated essentiality score=0.179; ProteomeLM contextual percentile=0.649; target-priority score=65.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 726 ML0906 O69560 rsmH mraW ML0906 MLCB268.10c Ribosomal RNA small subunit methyltransferase H (EC 2.1.1.199) (16S rRNA m(4)C1402 methyltransferase) (rRNA (cytosine-N(4)-)-methyltransferase RsmH) 372 0.02734 non-essential 0.17926 non-essential high NA high_confidence_nonessential NP_216681.4 73.7 0.69944 78.066 Strong candidate ESM-2 calibrated P(essential)=0.027; HANSEN integrated essentiality score=0.179; ProteomeLM contextual percentile=0.699; target-priority score=78.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 727 ML2174 Q9CBD3 cdd ML2174 Cytidine deaminase (EC 3.5.4.5) (Cytidine aminohydrolase) 134 0.00262 non-essential 0.17911 non-essential high NA high_confidence_nonessential NP_217832.1 56.8 0.80088 81.828 High-priority ESM-2 calibrated P(essential)=0.003; HANSEN integrated essentiality score=0.179; ProteomeLM contextual percentile=0.801; target-priority score=81.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 728 ML1896 Q9CBK7 rplJ ML1896 Large ribosomal subunit protein uL10 (50S ribosomal protein L10) 177 0.12891 non-essential 0.17883 non-essential high NA high_confidence_nonessential NP_215165.1 91.2 0.29618 55.866 Moderate candidate ESM-2 calibrated P(essential)=0.129; HANSEN integrated essentiality score=0.179; ProteomeLM contextual percentile=0.296; target-priority score=55.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 729 ML1369 Q7AQ59 ML1369 Segregation and condensation protein B 231 0.14132 non-essential 0.17882 non-essential high NA high_confidence_nonessential NP_216226.1 78.4 0.25235 51.392 Moderate candidate ESM-2 calibrated P(essential)=0.141; HANSEN integrated essentiality score=0.179; ProteomeLM contextual percentile=0.252; target-priority score=51.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 730 ML1689 Q7AQ28 ML1689 Possible hydrolase 242 0.06371 non-essential 0.17863 non-essential high NA high_confidence_nonessential NP_217509.3 85.9 0.56544 65.62 Strong candidate ESM-2 calibrated P(essential)=0.064; HANSEN integrated essentiality score=0.179; ProteomeLM contextual percentile=0.565; target-priority score=65.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 731 ML0615 Q9CCN3 subI ML0615 Sulphate-binding protein 348 0.03424 non-essential 0.17861 non-essential high NA high_confidence_nonessential NP_216916.1 76.5 0.6938 67.921 Strong candidate ESM-2 calibrated P(essential)=0.034; HANSEN integrated essentiality score=0.179; ProteomeLM contextual percentile=0.694; target-priority score=67.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 732 ML1167 P53425 ML1167 B1549_C2_208 Uncharacterized aminopeptidase ML1167 (EC 3.4.11.-) 362 0.07935 non-essential 0.17858 non-essential high NA high_confidence_nonessential NP_215849.1 76.1 0.49217 66.045 Strong candidate ESM-2 calibrated P(essential)=0.079; HANSEN integrated essentiality score=0.179; ProteomeLM contextual percentile=0.492; target-priority score=66.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 733 ML0016 P54744 pknB ML0016 Serine/threonine-protein kinase PknB (EC 2.7.11.1) 622 0.13642 non-essential 0.17854 non-essential high NA high_confidence_nonessential NP_214528.1 86.1 0.24609 60.596 Moderate candidate ESM-2 calibrated P(essential)=0.136; HANSEN integrated essentiality score=0.179; ProteomeLM contextual percentile=0.246; target-priority score=60.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 734 ML0396 Q57240 ML0396; ML2692 B1620_F3_113 L222-ORF2 Uncharacterized protein ML0396/ML2692 369 0.19217 non-essential 0.17823 non-essential high NA high_confidence_nonessential NP_214560.1 89.1 0.03006 46.453 Exploratory ESM-2 calibrated P(essential)=0.192; HANSEN integrated essentiality score=0.178; ProteomeLM contextual percentile=0.030; target-priority score=46.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 735 ML1965 Q7AQ10 rmlC ML1965 dTDP-4-dehydrorhamnose 3,5-epimerase (EC 5.1.3.13) (Thymidine diphospho-4-keto-rhamnose 3,5-epimerase) 202 0.00543 non-essential 0.17818 non-essential high NA high_confidence_nonessential NP_217982.1 75.4 0.77458 84.528 High-priority ESM-2 calibrated P(essential)=0.005; HANSEN integrated essentiality score=0.178; ProteomeLM contextual percentile=0.775; target-priority score=84.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 736 ML1233 Q49630 ML1233 Conserved membrane protein 230 0.01321 non-essential 0.17813 non-essential high NA high_confidence_nonessential NP_218338.1 45.0 0.78522 68.684 Strong candidate ESM-2 calibrated P(essential)=0.013; HANSEN integrated essentiality score=0.178; ProteomeLM contextual percentile=0.785; target-priority score=68.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 737 ML0073 Q9CDC6 ML0073 Membrane protein 344 0.10418 non-essential 0.178 non-essential high NA high_confidence_nonessential NP_218360.1 62.9 0.41014 54.042 Moderate candidate ESM-2 calibrated P(essential)=0.104; HANSEN integrated essentiality score=0.178; ProteomeLM contextual percentile=0.410; target-priority score=54.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 738 ML1784 Q9CBN2 adhE2 ML1784 Alcohol dehydrogenase (Zn dependent) 361 0.06371 non-essential 0.17799 non-essential high NA high_confidence_nonessential NP_216775.1 88.9 0.55917 66.476 Strong candidate ESM-2 calibrated P(essential)=0.064; HANSEN integrated essentiality score=0.178; ProteomeLM contextual percentile=0.559; target-priority score=66.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 739 ML1991 Q9CBG5 PPE ML1991 PPE-family protein 468 0.00198 non-essential 0.17795 non-essential high NA high_confidence_nonessential YP_177690.1 55.3 0.83532 68.806 Strong candidate ESM-2 calibrated P(essential)=0.002; HANSEN integrated essentiality score=0.178; ProteomeLM contextual percentile=0.835; target-priority score=68.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 740 ML2197 Q7APX8 ML2197 Integral membrane protein 161 0.00543 non-essential 0.17779 non-essential high NA high_confidence_nonessential 0.81277 70.763 Strong candidate ESM-2 calibrated P(essential)=0.005; HANSEN integrated essentiality score=0.178; ProteomeLM contextual percentile=0.813; target-priority score=70.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 741 ML2589 Q9CD14 mce1A ML2589 Cell invasion protein 441 0.0733 non-essential 0.17775 non-essential high NA high_confidence_nonessential YP_177701.1 66.1 0.53851 58.055 Moderate candidate ESM-2 calibrated P(essential)=0.073; HANSEN integrated essentiality score=0.178; ProteomeLM contextual percentile=0.539; target-priority score=58.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 742 ML1814 Q9CBL3 acn ML1814 Aconitate hydratase A (EC 4.2.1.3) (EC 4.2.1.99) ((2R,3S)-2-methylisocitrate dehydratase) ((2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate dehydratase) (Iron-responsive protein-like) (Probable 2-methyl-cis-aconitate hydratase) (RNA-binding protein) 944 0.10115 non-essential 0.17763 non-essential high NA high_confidence_nonessential NP_215991.1 87.1 0.38322 67.169 Strong candidate ESM-2 calibrated P(essential)=0.101; HANSEN integrated essentiality score=0.178; ProteomeLM contextual percentile=0.383; target-priority score=67.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:45Z 743 ML1769 Q9CBN7 uspE ML1769 Sugar transport integral membrane protein 274 0.03255 non-essential 0.17761 non-essential high NA high_confidence_nonessential YP_177866.1 85.0 0.69693 67.477 Strong candidate ESM-2 calibrated P(essential)=0.033; HANSEN integrated essentiality score=0.178; ProteomeLM contextual percentile=0.697; target-priority score=67.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 744 ML2157 Q9CBE0 ML2157 DNA 3'-5' helicase (EC 5.6.2.4) 549 0.19217 non-essential 0.17756 non-essential high NA high_confidence_nonessential NP_215376.3 91.1 0.01127 51.495 Moderate candidate ESM-2 calibrated P(essential)=0.192; HANSEN integrated essentiality score=0.178; ProteomeLM contextual percentile=0.011; target-priority score=51.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 745 ML1562 Q7AQ40 ML1562 Transmembrane efflux protein 534 0.01861 non-essential 0.17734 non-essential high NA high_confidence_nonessential NP_217362.1 86.5 0.75266 69.736 Strong candidate ESM-2 calibrated P(essential)=0.019; HANSEN integrated essentiality score=0.177; ProteomeLM contextual percentile=0.753; target-priority score=69.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 746 ML1696 O33112 ilvB ML1696 MLCB637.20 Acetolactate synthase (EC 2.2.1.6) (ALS) (Acetohydroxy-acid synthase) 625 0.13353 non-essential 0.17709 non-essential high NA high_confidence_nonessential YP_177917.1 86.2 0.23795 64.974 Moderate candidate ESM-2 calibrated P(essential)=0.134; HANSEN integrated essentiality score=0.177; ProteomeLM contextual percentile=0.238; target-priority score=65.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 747 ML0069 Q9CDC9 ML0069 HTH cro/C1-type domain-containing protein 132 0.01019 non-essential 0.17693 non-essential high NA high_confidence_nonessential NP_218366.1 84.0 0.78397 71.404 Strong candidate ESM-2 calibrated P(essential)=0.010; HANSEN integrated essentiality score=0.177; ProteomeLM contextual percentile=0.784; target-priority score=71.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 748 ML2075 Q7APZ4 ML2075 HTH merR-type domain-containing protein 251 0.12863 non-essential 0.17663 non-essential high NA high_confidence_nonessential NP_216344.1 86.5 0.2918 53.391 Moderate candidate ESM-2 calibrated P(essential)=0.129; HANSEN integrated essentiality score=0.177; ProteomeLM contextual percentile=0.292; target-priority score=53.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 749 ML1065 Q7AQ97 ML1065 Cell division protein DivIVA 114 0.09638 non-essential 0.17654 non-essential high agree high_confidence_nonessential Rv1209 79.5 NE 0 0.84847 67.723 Strong candidate ESM-2 calibrated P(essential)=0.096; HANSEN integrated essentiality score=0.177; Mtb RBH anchor Rv1209=non-essential (agree); ProteomeLM contextual percentile=0.848; target-priority score=67.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 750 ML0096 Q9CDB4 ML0096 Membrane protein 649 0.06543 non-essential 0.1762 non-essential high NA high_confidence_nonessential NP_218322.1 81.4 0.55416 61.914 Moderate candidate ESM-2 calibrated P(essential)=0.065; HANSEN integrated essentiality score=0.176; ProteomeLM contextual percentile=0.554; target-priority score=61.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 751 ML2093 Q50097 pstA phoX1 pstA1 ML2093 Phosphate transport system permease protein PstA 304 0.04985 non-essential 0.17589 non-essential high NA high_confidence_nonessential NP_215445.2 80.6 0.61553 64.74 Moderate candidate ESM-2 calibrated P(essential)=0.050; HANSEN integrated essentiality score=0.176; ProteomeLM contextual percentile=0.616; target-priority score=64.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 752 ML0244 Q9CD49 pth ML0244 Peptidyl-tRNA hydrolase (Pth) (EC 3.1.1.29) 199 0.06591 non-essential 0.17582 non-essential high NA high_confidence_nonessential NP_215530.1 77.7 0.51534 73.605 Strong candidate ESM-2 calibrated P(essential)=0.066; HANSEN integrated essentiality score=0.176; ProteomeLM contextual percentile=0.515; target-priority score=73.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 753 ML1623 O33012 htpG ML1623 MLCB250.19c Chaperone protein HtpG (Heat shock protein HtpG) (High temperature protein G) 656 0.09373 non-essential 0.1758 non-essential high NA high_confidence_nonessential NP_216815.1 80.8 0.43206 58.473 Moderate candidate ESM-2 calibrated P(essential)=0.094; HANSEN integrated essentiality score=0.176; ProteomeLM contextual percentile=0.432; target-priority score=58.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 754 ML0020 Q9CDE5 ML0020 Serine/threonine protein phosphatase PstP (EC 3.1.3.16) (Mycobacterial Ser/Thr phosphatase) (PP2C-family Ser/Thr phosphatase) 509 0.09928 non-essential 0.17573 non-essential high NA high_confidence_nonessential NP_214532.1 76.8 0.39449 62.461 Moderate candidate ESM-2 calibrated P(essential)=0.099; HANSEN integrated essentiality score=0.176; ProteomeLM contextual percentile=0.394; target-priority score=62.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 755 ML2617 O06079 mmpL11 ML2617 MLCL622.16c Probable transport protein MmpL11 1014 0.06278 non-essential 0.17531 non-essential high NA high_confidence_nonessential NP_214716.1 72.6 0.55855 62.768 Moderate candidate ESM-2 calibrated P(essential)=0.063; HANSEN integrated essentiality score=0.175; ProteomeLM contextual percentile=0.559; target-priority score=62.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:45Z 756 ML2061 Q7APZ9 ML2061 NADH:ubiquinone reductase (non-electrogenic) (EC 1.6.5.9) 466 0.10418 non-essential 0.17525 non-essential high NA high_confidence_nonessential NP_216370.1 90.8 0.36068 65.36 Strong candidate ESM-2 calibrated P(essential)=0.104; HANSEN integrated essentiality score=0.175; ProteomeLM contextual percentile=0.361; target-priority score=65.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 757 ML0134 Q9CD82 fadD22 ML0134 Acyl-CoA synthetase 707 0.09638 non-essential 0.17511 non-essential high NA high_confidence_nonessential NP_217464.1 75.9 0.4139 59.141 Moderate candidate ESM-2 calibrated P(essential)=0.096; HANSEN integrated essentiality score=0.175; ProteomeLM contextual percentile=0.414; target-priority score=59.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 758 ML0049 Q50206 esxA esaT6 esx L45 ML0049 MLCB628.12c 6 kDa early secretory antigenic target homolog (ESAT-6-like protein) (L-ESAT) 95 0.0 non-essential 0.175 non-essential high NA high_confidence_nonessential 0.82342 70.034 Strong candidate ESM-2 calibrated P(essential)=0.000; HANSEN integrated essentiality score=0.175; ProteomeLM contextual percentile=0.823; target-priority score=70.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 759 ML0252 Q9CD43 mfd ML0252 Transcription-repair-coupling factor (TRCF) (EC 3.6.4.-) 1224 0.07654 non-essential 0.1749 non-essential high NA high_confidence_nonessential NP_215536.1 84.2 0.48842 64.33 Moderate candidate ESM-2 calibrated P(essential)=0.077; HANSEN integrated essentiality score=0.175; ProteomeLM contextual percentile=0.488; target-priority score=64.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:45Z 760 ML1077 Q9CCA5 ML1077 RNA polymerase subunit sigma-70 139 0.03079 non-essential 0.17482 non-essential high NA high_confidence_nonessential NP_215738.1 67.8 0.69818 64.224 Moderate candidate ESM-2 calibrated P(essential)=0.031; HANSEN integrated essentiality score=0.175; ProteomeLM contextual percentile=0.698; target-priority score=64.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 761 ML1037 Q7AQA5 ML1037 CBS domain-containing protein 184 0.09148 non-essential 0.17471 non-essential high agree high_confidence_nonessential Rv2683 73.8 NE 0 0.84596 70.449 Strong candidate ESM-2 calibrated P(essential)=0.091; HANSEN integrated essentiality score=0.175; Mtb RBH anchor Rv2683=non-essential (agree); ProteomeLM contextual percentile=0.846; target-priority score=70.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 762 ML0759 Q9CCK1 fbiA ML0759 Phosphoenolpyruvate transferase (EC 2.7.8.28) (EPPG:FO PEP transferase) 333 0.05767 non-essential 0.17458 non-essential high NA high_confidence_nonessential NP_217778.1 79.3 0.53914 75.88 Strong candidate ESM-2 calibrated P(essential)=0.058; HANSEN integrated essentiality score=0.175; ProteomeLM contextual percentile=0.539; target-priority score=75.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 763 ML0091 P19361 ML0091 28 kDa antigen 236 0.00674 non-essential 0.17429 non-essential high NA high_confidence_nonessential NP_218327.1 49.3 0.80338 64.911 Moderate candidate ESM-2 calibrated P(essential)=0.007; HANSEN integrated essentiality score=0.174; ProteomeLM contextual percentile=0.803; target-priority score=64.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 764 ML0373 P37391 nnr ML0373 B229_C2_201 u229g Bifunctional NAD(P)H-hydrate repair enzyme Nnr (Nicotinamide nucleotide repair protein) [Includes: ADP-dependent (S)-NAD(P)H-hydrate dehydratase (EC 4.2.1.136) (ADP-dependent NAD(P)HX dehydratase); NAD(P)H-hydrate epimerase (EC 5.1.99.6) (NAD(P)HX epimerase)] 473 0.08711 non-essential 0.17425 non-essential high NA high_confidence_nonessential NP_217950.1 81.4 0.42016 69.756 Strong candidate ESM-2 calibrated P(essential)=0.087; HANSEN integrated essentiality score=0.174; ProteomeLM contextual percentile=0.420; target-priority score=69.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 765 ML1512 Q9CBW5 rnj ML1512 Ribonuclease J (RNase J) (EC 3.1.-.-) 558 0.14132 non-essential 0.17412 non-essential high NA high_confidence_nonessential NP_217268.1 89.2 0.20539 57.947 Moderate candidate ESM-2 calibrated P(essential)=0.141; HANSEN integrated essentiality score=0.174; ProteomeLM contextual percentile=0.205; target-priority score=57.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 766 ML0205 Q7AQL9 ML0205 Membrane protein 356 0.01019 non-essential 0.17406 non-essential high NA high_confidence_nonessential NP_218146.1 66.2 0.77395 69.087 Strong candidate ESM-2 calibrated P(essential)=0.010; HANSEN integrated essentiality score=0.174; ProteomeLM contextual percentile=0.774; target-priority score=69.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 767 ML0519 Q9CCS3 aroQ aroD ML0519 3-dehydroquinate dehydratase (3-dehydroquinase) (EC 4.2.1.10) (Type II DHQase) 145 0.01172 non-essential 0.17404 non-essential high NA high_confidence_nonessential NP_217053.1 85.3 0.72636 82.835 High-priority ESM-2 calibrated P(essential)=0.012; HANSEN integrated essentiality score=0.174; ProteomeLM contextual percentile=0.726; target-priority score=82.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 768 ML2254 Q50167 otsA ML2254 Trehalose-6-phosphate synthase (TPS) (EC 2.4.1.15) (EC 2.4.1.347) (Alpha,alpha-trehalose-phosphate synthase [UDP-forming]) (Osmoregulatory trehalose synthesis protein A) (OtsA) 498 0.1795 non-essential 0.17383 non-essential high NA high_confidence_nonessential NP_218007.1 80.3 0.0288 57.833 Moderate candidate ESM-2 calibrated P(essential)=0.180; HANSEN integrated essentiality score=0.174; ProteomeLM contextual percentile=0.029; target-priority score=57.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 769 ML2226 Q7APX4 ptrB ML2226 Protease II 724 0.056 non-essential 0.1738 non-essential high NA high_confidence_nonessential 0.57232 65.652 Strong candidate ESM-2 calibrated P(essential)=0.056; HANSEN integrated essentiality score=0.174; ProteomeLM contextual percentile=0.572; target-priority score=65.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 770 ML1273 Q9CC53 trpA ML1273 Tryptophan synthase alpha chain (EC 4.2.1.20) 270 0.05255 non-essential 0.17361 non-essential high NA high_confidence_nonessential NP_216129.1 86.0 0.55542 76.401 Strong candidate ESM-2 calibrated P(essential)=0.053; HANSEN integrated essentiality score=0.174; ProteomeLM contextual percentile=0.555; target-priority score=76.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 771 ML1426 Q7AQ52 ML1426 Probable ABC-transport protein, inner membrane component 319 0.05112 non-essential 0.1733 non-essential high NA high_confidence_nonessential NP_216556.1 81.6 0.59674 63.958 Moderate candidate ESM-2 calibrated P(essential)=0.051; HANSEN integrated essentiality score=0.173; ProteomeLM contextual percentile=0.597; target-priority score=64.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 772 ML2379 Q9CB69 ML2379 Uncharacterized protein 109 0.00543 non-essential 0.17327 non-essential high NA high_confidence_nonessential 0.79274 68.55 Strong candidate ESM-2 calibrated P(essential)=0.005; HANSEN integrated essentiality score=0.173; ProteomeLM contextual percentile=0.793; target-priority score=68.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 773 ML2048 Q7AQ01 ML2048 Uncharacterized protein 85 0.06931 non-essential 0.17319 non-essential high agree high_confidence_nonessential Rv1871c 62.0 NE 0 0.94427 74.343 Strong candidate ESM-2 calibrated P(essential)=0.069; HANSEN integrated essentiality score=0.173; Mtb RBH anchor Rv1871c=non-essential (agree); ProteomeLM contextual percentile=0.944; target-priority score=74.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 774 ML0199 Q7AQM4 ML0199 ML0199 protein 200 0.14222 non-essential 0.17316 non-essential high agree high_confidence_nonessential Rv3647c 80.9 NE 0 0.56669 62.323 Moderate candidate ESM-2 calibrated P(essential)=0.142; HANSEN integrated essentiality score=0.173; Mtb RBH anchor Rv3647c=non-essential (agree); ProteomeLM contextual percentile=0.567; target-priority score=62.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 775 ML2647 Q9CCZ3 msrA ML2647 Peptide methionine sulfoxide reductase MsrA (Protein-methionine-S-oxide reductase) (EC 1.8.4.11) (Peptide-methionine (S)-S-oxide reductase) (Peptide Met(O) reductase) 177 0.00543 non-essential 0.17278 non-essential high NA high_confidence_nonessential NP_214651.1 80.0 0.75579 80.129 High-priority ESM-2 calibrated P(essential)=0.005; HANSEN integrated essentiality score=0.173; ProteomeLM contextual percentile=0.756; target-priority score=80.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 776 ML0956 Q9CCC8 ML0956 Integral membrane protein 169 0.00198 non-essential 0.17273 non-essential high NA high_confidence_nonessential 0.79461 72.208 Strong candidate ESM-2 calibrated P(essential)=0.002; HANSEN integrated essentiality score=0.173; ProteomeLM contextual percentile=0.795; target-priority score=72.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 777 ML2134 O33064 fprB ML2134 MLCB57.39 Probable ferredoxin/ferredoxin--NADP reductase (FNR) (EC 1.18.1.2) 555 0.08883 non-essential 0.17234 non-essential high NA high_confidence_nonessential NP_215401.1 76.1 0.40388 68.784 Strong candidate ESM-2 calibrated P(essential)=0.089; HANSEN integrated essentiality score=0.172; ProteomeLM contextual percentile=0.404; target-priority score=68.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 778 ML0125 Q9CD91 ML0125 Glycosyl transferase 438 0.03172 non-essential 0.17217 non-essential high NA high_confidence_nonessential NP_217478.1 77.5 0.66562 68.558 Strong candidate ESM-2 calibrated P(essential)=0.032; HANSEN integrated essentiality score=0.172; ProteomeLM contextual percentile=0.666; target-priority score=68.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 779 ML0758 Q9CCK2 fbiB ML0758 Bifunctional F420 biosynthesis protein FbiB [Includes: Coenzyme F420:L-glutamate ligase (EC 6.3.2.31) (EC 6.3.2.34) (Coenzyme F420-0:L-glutamate ligase) (Coenzyme F420-1:gamma-L-glutamate ligase); Dehydro-coenzyme F420-0 reductase (EC 1.3.8.17)] 457 0.07497 non-essential 0.17212 non-essential high NA high_confidence_nonessential NP_217779.1 82.2 0.45272 73.352 Strong candidate ESM-2 calibrated P(essential)=0.075; HANSEN integrated essentiality score=0.172; ProteomeLM contextual percentile=0.453; target-priority score=73.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 780 ML1862 O32982 rplD ML1862 MLCB2492.03 Large ribosomal subunit protein uL4 (50S ribosomal protein L4) 230 0.15001 non-essential 0.1721 non-essential high NA high_confidence_nonessential NP_215216.1 86.7 0.17345 51.221 Moderate candidate ESM-2 calibrated P(essential)=0.150; HANSEN integrated essentiality score=0.172; ProteomeLM contextual percentile=0.173; target-priority score=51.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 781 ML1833 O33006 secY ML1833 MLCB2492.27 Protein translocase subunit SecY 438 0.10152 non-essential 0.17202 non-essential high NA high_confidence_nonessential NP_215246.1 91.8 0.38134 55.997 Moderate candidate ESM-2 calibrated P(essential)=0.102; HANSEN integrated essentiality score=0.172; ProteomeLM contextual percentile=0.381; target-priority score=56.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 782 ML2271 Q9CBA9 ML2271 Membrane protein 175 0.02338 non-essential 0.17202 non-essential high NA high_confidence_nonessential NP_215070.1 79.8 0.71008 66.137 Strong candidate ESM-2 calibrated P(essential)=0.023; HANSEN integrated essentiality score=0.172; ProteomeLM contextual percentile=0.710; target-priority score=66.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 783 ML1259 Q9X7B9 hisB ML1259 MLCB1610.22 Imidazoleglycerol-phosphate dehydratase (IGPD) (EC 4.2.1.19) 210 0.02543 non-essential 0.17198 non-essential high NA high_confidence_nonessential NP_216117.1 85.2 0.66625 77.772 Strong candidate ESM-2 calibrated P(essential)=0.025; HANSEN integrated essentiality score=0.172; ProteomeLM contextual percentile=0.666; target-priority score=77.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 784 ML1207 Q9X7F0 dnaE ML1207 MLCB458.21 DNA polymerase III subunit alpha (EC 2.7.7.7) 1177 0.08883 non-essential 0.17168 non-essential high NA high_confidence_nonessential NP_216063.1 91.2 0.40764 66.176 Strong candidate ESM-2 calibrated P(essential)=0.089; HANSEN integrated essentiality score=0.172; ProteomeLM contextual percentile=0.408; target-priority score=66.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:45Z 785 ML0736 P46702 purE ML0736 B1308_F3_98 N5-carboxyaminoimidazole ribonucleotide mutase (N5-CAIR mutase) (EC 5.4.99.18) (5-(carboxyamino)imidazole ribonucleotide mutase) 171 0.10537 non-essential 0.17163 non-essential high NA high_confidence_nonessential NP_217792.1 81.5 0.32498 68.381 Strong candidate ESM-2 calibrated P(essential)=0.105; HANSEN integrated essentiality score=0.172; ProteomeLM contextual percentile=0.325; target-priority score=68.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 786 ML1994 Q7AQ08 fadD10 ML1994 Acyl-CoA synthase 532 0.10418 non-essential 0.17156 non-essential high NA high_confidence_nonessential NP_214613.1 74.6 0.3613 57.758 Moderate candidate ESM-2 calibrated P(essential)=0.104; HANSEN integrated essentiality score=0.172; ProteomeLM contextual percentile=0.361; target-priority score=57.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 787 ML2407 Q9CB63 ML2407 Membrane protein 111 0.01233 non-essential 0.17156 non-essential high NA high_confidence_nonessential NP_215045.1 64.9 0.76143 65.011 Strong candidate ESM-2 calibrated P(essential)=0.012; HANSEN integrated essentiality score=0.172; ProteomeLM contextual percentile=0.761; target-priority score=65.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 788 ML1371 Q49885 cmk ML1371 MLCB1351.02c Cytidylate kinase (CK) (EC 2.7.4.25) (Cytidine monophosphate kinase) (CMP kinase) 223 0.13829 non-essential 0.17144 non-essential high NA high_confidence_nonessential NP_216228.1 74.8 0.19662 60.302 Moderate candidate ESM-2 calibrated P(essential)=0.138; HANSEN integrated essentiality score=0.171; ProteomeLM contextual percentile=0.197; target-priority score=60.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 789 ML1016 Q7AQB3 ML1016 DUF3039 domain-containing protein 107 0.08936 non-essential 0.1714 non-essential high agree high_confidence_nonessential Rv2708c 88.6 GA 0 0.83657 68.255 Strong candidate ESM-2 calibrated P(essential)=0.089; HANSEN integrated essentiality score=0.171; Mtb RBH anchor Rv2708c=non-essential (agree); ProteomeLM contextual percentile=0.837; target-priority score=68.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 790 ML2012 Q7AQ04 ML2012 Membrane protein 139 0.00543 non-essential 0.17128 non-essential high NA high_confidence_nonessential NP_216419.1 80.6 0.77833 69.452 Strong candidate ESM-2 calibrated P(essential)=0.005; HANSEN integrated essentiality score=0.171; ProteomeLM contextual percentile=0.778; target-priority score=69.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 791 ML0287 O69601 ML0287 MLCB4.30 Uncharacterized membrane protein ML0287 222 0.03424 non-essential 0.17124 non-essential high NA high_confidence_nonessential NP_214878.1 66.1 0.65686 65.743 Strong candidate ESM-2 calibrated P(essential)=0.034; HANSEN integrated essentiality score=0.171; ProteomeLM contextual percentile=0.657; target-priority score=65.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 792 ML0732 Q9CCL3 birA ML0732 biotin--[biotin carboxyl-carrier protein] ligase (EC 6.3.4.15) 274 0.06636 non-essential 0.17076 non-essential high NA high_confidence_nonessential NP_217796.1 71.2 0.5047 66.407 Strong candidate ESM-2 calibrated P(essential)=0.066; HANSEN integrated essentiality score=0.171; ProteomeLM contextual percentile=0.505; target-priority score=66.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 793 ML0392 Q49736 ML0392 B1620_F1_30 Uncharacterized glycosyl hydrolase ML0392 (EC 3.2.1.-) 792 0.0338 non-essential 0.17054 non-essential high NA high_confidence_nonessential NP_217918.1 91.4 0.63306 73.105 Strong candidate ESM-2 calibrated P(essential)=0.034; HANSEN integrated essentiality score=0.171; ProteomeLM contextual percentile=0.633; target-priority score=73.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:45Z 794 ML1013 Q9CCB5 ideR ML1013 Iron-dependent repressor IdeR 230 0.18412 non-essential 0.17036 non-essential high NA high_confidence_nonessential NP_217227.1 90.0 0.02254 45.818 Exploratory ESM-2 calibrated P(essential)=0.184; HANSEN integrated essentiality score=0.170; ProteomeLM contextual percentile=0.023; target-priority score=45.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 795 ML0419 Q9CCU7 ML0419 Putative tRNA (cytidine(34)-2'-O)-methyltransferase (EC 2.1.1.207) (tRNA (cytidine/uridine-2'-O-)-methyltransferase) 158 0.09148 non-essential 0.1703 non-essential high NA high_confidence_nonessential NP_217883.1 83.8 0.3851 66.957 Strong candidate ESM-2 calibrated P(essential)=0.091; HANSEN integrated essentiality score=0.170; ProteomeLM contextual percentile=0.385; target-priority score=67.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 796 ML1919 Q9CBJ1 ML1919 Carbonic anhydrase (EC 4.2.1.1) (Carbonate dehydratase) 213 0.05258 non-essential 0.17001 non-essential high NA high_confidence_nonessential NP_218105.1 84.5 0.54477 72.766 Strong candidate ESM-2 calibrated P(essential)=0.053; HANSEN integrated essentiality score=0.170; ProteomeLM contextual percentile=0.545; target-priority score=72.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 797 ML0222 Q9CD58 ftsH ML0222 MLCB2548.09c ATP-dependent zinc metalloprotease FtsH (EC 3.4.24.-) 787 0.07935 non-essential 0.17 non-essential high NA high_confidence_nonessential NP_218127.1 92.7 0.44584 64.643 Moderate candidate ESM-2 calibrated P(essential)=0.079; HANSEN integrated essentiality score=0.170; ProteomeLM contextual percentile=0.446; target-priority score=64.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:45Z 798 ML1124 Q9CC79 ML1124 Probable binding-protein dependent transport protein 325 0.01889 non-essential 0.16999 non-essential high NA high_confidence_nonessential NP_215799.1 83.4 0.71133 68.66 Strong candidate ESM-2 calibrated P(essential)=0.019; HANSEN integrated essentiality score=0.170; ProteomeLM contextual percentile=0.711; target-priority score=68.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 799 ML1492 Q9CBX6 fbiC ML1492 FO synthase [Includes: 7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase (EC 4.3.1.32); 5-amino-6-(D-ribitylamino)uracil--L-tyrosine 4-hydroxyphenyl transferase (EC 2.5.1.147)] 863 0.09638 non-essential 0.16988 non-essential high NA high_confidence_nonessential NP_215689.1 88.5 0.35316 69.333 Strong candidate ESM-2 calibrated P(essential)=0.096; HANSEN integrated essentiality score=0.170; ProteomeLM contextual percentile=0.353; target-priority score=69.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:45Z 800 ML0675 Q7AQG3 ML0675 Integral membrane protein 91 0.04401 non-essential 0.1698 non-essential high NA high_confidence_nonessential NP_217872.1 78.9 0.61428 62.098 Moderate candidate ESM-2 calibrated P(essential)=0.044; HANSEN integrated essentiality score=0.170; ProteomeLM contextual percentile=0.614; target-priority score=62.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 801 ML0055 O33089 eccA1 ML0055 MLCB628.18c ESX-1 secretion system protein EccA1 (ESX conserved component A1) (Type VII secretion system protein EccA1) (T7SS protein EccA1) 573 0.06554 non-essential 0.16959 non-essential high NA high_confidence_nonessential NP_218385.1 89.2 0.50971 63.652 Moderate candidate ESM-2 calibrated P(essential)=0.066; HANSEN integrated essentiality score=0.170; ProteomeLM contextual percentile=0.510; target-priority score=63.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 802 ML1249 Q7AQ79 ML1249 Uncharacterized protein 1622 0.10045 non-essential 0.16951 non-essential high NA high_confidence_nonessential NP_216992.1 81.2 0.36944 56.714 Moderate candidate ESM-2 calibrated P(essential)=0.100; HANSEN integrated essentiality score=0.170; ProteomeLM contextual percentile=0.369; target-priority score=56.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:45Z 803 ML0905 O69561 mraZ ML0905 MLCB268.11c Transcriptional regulator MraZ 143 0.00674 non-essential 0.1695 non-essential high NA high_confidence_nonessential NP_216682.1 92.3 0.75642 71.293 Strong candidate ESM-2 calibrated P(essential)=0.007; HANSEN integrated essentiality score=0.169; ProteomeLM contextual percentile=0.756; target-priority score=71.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 804 ML2706 Q50201 parB ML2706 Probable chromosome-partitioning protein ParB 333 0.18715 non-essential 0.16947 non-essential high NA high_confidence_nonessential NP_218435.2 78.6 0.01503 41.876 Exploratory ESM-2 calibrated P(essential)=0.187; HANSEN integrated essentiality score=0.169; ProteomeLM contextual percentile=0.015; target-priority score=41.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 805 ML2609 Q7APT4 ML2609 CopY family transcriptional regulator 135 0.07065 non-essential 0.16943 non-essential high agree high_confidence_nonessential Rv0190 82.6 GA 0 0.89856 74.373 Strong candidate ESM-2 calibrated P(essential)=0.071; HANSEN integrated essentiality score=0.169; Mtb RBH anchor Rv0190=non-essential (agree); ProteomeLM contextual percentile=0.899; target-priority score=74.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 806 ML1480 Q9CBY3 clpP1 clpP ML1480 ATP-dependent Clp protease proteolytic subunit 1 (EC 3.4.21.92) (Endopeptidase Clp 1) 200 0.09306 non-essential 0.16932 non-essential high NA high_confidence_nonessential YP_177883.1 95.0 0.3757 65.722 Strong candidate ESM-2 calibrated P(essential)=0.093; HANSEN integrated essentiality score=0.169; ProteomeLM contextual percentile=0.376; target-priority score=65.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 807 ML0484 Q9CCT4 fadD9 car ML0484 Carboxylic acid reductase (CAR) (EC 1.2.1.-) (ATP/NADPH-dependent carboxylic acid reductase) 1188 0.10115 non-essential 0.16921 non-essential high NA high_confidence_nonessential NP_217106.1 68.3 0.34001 65.035 Strong candidate ESM-2 calibrated P(essential)=0.101; HANSEN integrated essentiality score=0.169; ProteomeLM contextual percentile=0.340; target-priority score=65.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:45Z 808 ML0151 Q9CD74 ML0151 Chorismate mutase domain-containing protein 105 0.09187 non-essential 0.16915 non-essential high NA high_confidence_nonessential NP_215463.1 83.8 0.40889 55.96 Moderate candidate ESM-2 calibrated P(essential)=0.092; HANSEN integrated essentiality score=0.169; ProteomeLM contextual percentile=0.409; target-priority score=56.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 809 ML1315 Q49803 lppK ML1315 B2126_F3_115 MLCB2533.11c Putative lipoprotein LppK 194 0.01019 non-essential 0.16914 non-essential high NA high_confidence_nonessential NP_216632.1 51.7 0.74828 67.965 Strong candidate ESM-2 calibrated P(essential)=0.010; HANSEN integrated essentiality score=0.169; ProteomeLM contextual percentile=0.748; target-priority score=68.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 810 ML0225 O69529 folB ML0225 MLCB2548.06c Dihydroneopterin aldolase (DHNA) (EC 4.1.2.25) (7,8-dihydroneopterin 2'-epimerase) (7,8-dihydroneopterin aldolase) (7,8-dihydroneopterin epimerase) (EC 5.1.99.8) (7,8-dihydroneopterin hydroxylase) (EC 1.13.11.81) (Dihydroneopterin epimerase) (Dihydroneopterin hydroxylase) 132 0.06738 non-essential 0.169 non-essential high NA high_confidence_nonessential YP_177996.1 74.8 0.46587 74.501 Strong candidate ESM-2 calibrated P(essential)=0.067; HANSEN integrated essentiality score=0.169; ProteomeLM contextual percentile=0.466; target-priority score=74.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 811 ML1271 Q9X7C7 trpC ML1271 MLCB1610.33 Indole-3-glycerol phosphate synthase (IGPS) (EC 4.1.1.48) 272 0.0499 non-essential 0.16878 non-essential high NA high_confidence_nonessential NP_216127.1 90.8 0.54665 73.864 Strong candidate ESM-2 calibrated P(essential)=0.050; HANSEN integrated essentiality score=0.169; ProteomeLM contextual percentile=0.547; target-priority score=73.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 812 ML1158 P46707 fadA4 ML1158 B1549_C1_166 Probable acetyl-CoA acetyltransferase (EC 2.3.1.9) (Acetoacetyl-CoA thiolase) 393 0.09148 non-essential 0.1687 non-essential high NA high_confidence_nonessential NP_215839.1 86.9 0.37445 67.365 Strong candidate ESM-2 calibrated P(essential)=0.091; HANSEN integrated essentiality score=0.169; ProteomeLM contextual percentile=0.374; target-priority score=67.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 813 ML1056 Q49946 ML1056 u1756d; ML1180 MLCB1701.06c Putative ESAT-6-like protein X 95 0.0 non-essential 0.16843 non-essential high NA high_confidence_nonessential NP_215553.1 64.8 0.78898 68.603 Strong candidate ESM-2 calibrated P(essential)=0.000; HANSEN integrated essentiality score=0.168; ProteomeLM contextual percentile=0.789; target-priority score=68.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 814 ML2020 Q9CBG0 ML2020 Putative S-adenosyl-L-methionine-dependent methyltransferase ML2020 (EC 2.1.1.-) 303 0.00543 non-essential 0.16835 non-essential high NA high_confidence_nonessential NP_216412.1 78.0 0.73951 76.791 Strong candidate ESM-2 calibrated P(essential)=0.005; HANSEN integrated essentiality score=0.168; ProteomeLM contextual percentile=0.740; target-priority score=76.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 815 ML1714 Q9CBR4 ML1714 1,4-alpha-glucan branching enzyme (EC 2.4.1.18) (1,4-alpha-D-glucan:1,4-alpha-D-glucan 6-glucosyl-transferase) (Alpha-(1->4)-glucan branching enzyme) (Branching enzyme) 522 0.06199 non-essential 0.16833 non-essential high NA high_confidence_nonessential NP_217547.1 86.3 0.49593 71.348 Strong candidate ESM-2 calibrated P(essential)=0.062; HANSEN integrated essentiality score=0.168; ProteomeLM contextual percentile=0.496; target-priority score=71.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 816 ML0598 Q7AQH3 ML0598 MIP18 family-like domain-containing protein 115 0.07767 non-essential 0.16822 non-essential high NA high_confidence_nonessential Rv1466 82.6 UNCERTAIN 0.46337 57.713 Moderate candidate ESM-2 calibrated P(essential)=0.078; HANSEN integrated essentiality score=0.168; ProteomeLM contextual percentile=0.463; target-priority score=57.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 817 ML1727 Q9CBQ6 ML1727 phosphoserine phosphatase (EC 3.1.3.3) (O-phosphoserine phosphohydrolase) 411 0.09625 non-essential 0.16776 non-essential high NA high_confidence_nonessential NP_217558.1 86.3 0.34314 68.699 Strong candidate ESM-2 calibrated P(essential)=0.096; HANSEN integrated essentiality score=0.168; ProteomeLM contextual percentile=0.343; target-priority score=68.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 818 ML2305 Q9CB88 ML2305 Probable anion transporter protein 341 0.13339 non-essential 0.16747 non-essential high NA high_confidence_nonessential NP_218196.1 84.2 0.22104 51.707 Moderate candidate ESM-2 calibrated P(essential)=0.133; HANSEN integrated essentiality score=0.167; ProteomeLM contextual percentile=0.221; target-priority score=51.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 819 ML0571 P46712 pgk ML0571 B1496_C2_162 Phosphoglycerate kinase (EC 2.7.2.3) 416 0.13884 non-essential 0.1674 non-essential high NA high_confidence_nonessential NP_215953.1 80.4 0.16343 62.645 Moderate candidate ESM-2 calibrated P(essential)=0.139; HANSEN integrated essentiality score=0.167; ProteomeLM contextual percentile=0.163; target-priority score=62.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 820 ML1992 Q9CBG4 ML1992 Oxidoreductase 289 0.09625 non-essential 0.16696 non-essential high NA high_confidence_nonessential NP_214611.1 76.4 0.36819 58.586 Moderate candidate ESM-2 calibrated P(essential)=0.096; HANSEN integrated essentiality score=0.167; ProteomeLM contextual percentile=0.368; target-priority score=58.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 821 ML0903 Q7AQC8 ML0903 N-acetyltransferase domain-containing protein 210 0.02105 non-essential 0.16671 non-essential high NA high_confidence_nonessential NP_216686.1 77.1 0.68003 69.375 Strong candidate ESM-2 calibrated P(essential)=0.021; HANSEN integrated essentiality score=0.167; ProteomeLM contextual percentile=0.680; target-priority score=69.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 822 ML1329 P54076 pafB ML1329 B2126_C3_266 MLCB2533.25 Protein PafB 331 0.05933 non-essential 0.16661 non-essential high NA high_confidence_nonessential NP_216612.1 80.2 0.53475 58.841 Moderate candidate ESM-2 calibrated P(essential)=0.059; HANSEN integrated essentiality score=0.167; ProteomeLM contextual percentile=0.535; target-priority score=58.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 823 ML1172 P46705 murI ML1172 B1549_C2_210 Glutamate racemase (EC 5.1.1.3) 272 0.09625 non-essential 0.16636 non-essential high NA high_confidence_nonessential NP_215854.1 88.9 0.32874 70.804 Strong candidate ESM-2 calibrated P(essential)=0.096; HANSEN integrated essentiality score=0.166; ProteomeLM contextual percentile=0.329; target-priority score=70.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 824 ML1297 Q9CC42 uppP bacA upk ML1297 B2126_C2_190/B2126_C3_227 Undecaprenyl-diphosphatase (EC 3.6.1.27) (Bacitracin resistance protein) (Undecaprenyl pyrophosphate phosphatase) 282 0.02105 non-essential 0.16635 non-essential high NA high_confidence_nonessential NP_216652.1 82.6 0.65874 75.881 Strong candidate ESM-2 calibrated P(essential)=0.021; HANSEN integrated essentiality score=0.166; ProteomeLM contextual percentile=0.659; target-priority score=75.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 825 ML2596 Q9CD07 ML2596 Conserved membrane protein 325 0.01889 non-essential 0.16601 non-essential high NA high_confidence_nonessential NP_214690.1 55.2 0.6913 67.524 Strong candidate ESM-2 calibrated P(essential)=0.019; HANSEN integrated essentiality score=0.166; ProteomeLM contextual percentile=0.691; target-priority score=67.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 826 ML2457 Q9CB41 ML2457 Possible TetR-family transcriptional regulator 233 0.0332 non-essential 0.16595 non-essential high NA high_confidence_nonessential NP_214986.1 90.0 0.62805 66.584 Strong candidate ESM-2 calibrated P(essential)=0.033; HANSEN integrated essentiality score=0.166; ProteomeLM contextual percentile=0.628; target-priority score=66.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 827 ML1598 O33038 rpsB ML1598 MLCB250.63 Small ribosomal subunit protein uS2 (30S ribosomal protein S2) 277 0.14132 non-essential 0.16584 non-essential high NA high_confidence_nonessential NP_217406.1 94.9 0.17408 52.032 Moderate candidate ESM-2 calibrated P(essential)=0.141; HANSEN integrated essentiality score=0.166; ProteomeLM contextual percentile=0.174; target-priority score=52.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 828 ML0248 Q9CD45 prs prsA ML0248 Ribose-phosphate pyrophosphokinase (RPPK) (EC 2.7.6.1) (5-phospho-D-ribosyl alpha-1-diphosphate synthase) (Phosphoribosyl diphosphate synthase) (Phosphoribosyl pyrophosphate synthase) (P-Rib-PP synthase) (PRPP synthase) (PRPPase) 327 0.14132 non-essential 0.16573 non-essential high NA high_confidence_nonessential NP_215533.1 92.0 0.14465 61.821 Moderate candidate ESM-2 calibrated P(essential)=0.141; HANSEN integrated essentiality score=0.166; ProteomeLM contextual percentile=0.145; target-priority score=61.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 829 ML1091 P50917 mdh ML1091 Malate dehydrogenase (EC 1.1.1.37) 329 0.14132 non-essential 0.16568 non-essential high NA high_confidence_nonessential NP_215756.1 89.4 0.14903 60.226 Moderate candidate ESM-2 calibrated P(essential)=0.141; HANSEN integrated essentiality score=0.166; ProteomeLM contextual percentile=0.149; target-priority score=60.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 830 ML0467 Q49642 ML0467 B1177_C2_172/B1177_C1_140 MLCL581.27 Uncharacterized membrane protein ML0467 214 0.01017 non-essential 0.16545 non-essential high NA high_confidence_nonessential NP_217153.1 79.9 0.72448 68.711 Strong candidate ESM-2 calibrated P(essential)=0.010; HANSEN integrated essentiality score=0.165; ProteomeLM contextual percentile=0.724; target-priority score=68.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 831 ML2443 P54138 mshA ML2443 B2168_C2_201 u2168f D-inositol 3-phosphate glycosyltransferase (EC 2.4.1.250) (N-acetylglucosamine-inositol-phosphate N-acetylglucosaminyltransferase) (GlcNAc-Ins-P N-acetylglucosaminyltransferase) 428 0.1084 non-essential 0.16531 non-essential high NA high_confidence_nonessential NP_215000.1 86.6 0.28804 63.586 Moderate candidate ESM-2 calibrated P(essential)=0.108; HANSEN integrated essentiality score=0.165; ProteomeLM contextual percentile=0.288; target-priority score=63.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 832 ML0844 Q7AQF2 narK ML0844 Nitrite extrusion protein 517 0.00198 non-essential 0.16515 non-essential high NA high_confidence_nonessential NP_216845.1 69.1 0.75704 69.813 Strong candidate ESM-2 calibrated P(essential)=0.002; HANSEN integrated essentiality score=0.165; ProteomeLM contextual percentile=0.757; target-priority score=69.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 833 ML2296 Q9CB97 ML2296 Membrane protein 181 0.02752 non-essential 0.16512 non-essential high NA high_confidence_nonessential NP_218186.1 75.7 0.66249 62.071 Moderate candidate ESM-2 calibrated P(essential)=0.028; HANSEN integrated essentiality score=0.165; ProteomeLM contextual percentile=0.662; target-priority score=62.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 834 ML1088 Q9CCA1 ML1088 Trehalose transport system permease protein SugB 287 0.03466 non-essential 0.16495 non-essential high NA high_confidence_nonessential NP_215753.1 89.7 0.62116 64.638 Moderate candidate ESM-2 calibrated P(essential)=0.035; HANSEN integrated essentiality score=0.165; ProteomeLM contextual percentile=0.621; target-priority score=64.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 835 ML1171 P53426 ML1171 B1549_C3_240 Uncharacterized protein ML1171 251 0.00432 non-essential 0.1647 non-essential high NA high_confidence_nonessential NP_215853.1 73.9 0.74703 68.674 Strong candidate ESM-2 calibrated P(essential)=0.004; HANSEN integrated essentiality score=0.165; ProteomeLM contextual percentile=0.747; target-priority score=68.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 836 ML0666 O32886 fprA ML0666 MLCB1779.25 NADPH-ferredoxin reductase FprA (NFR) (EC 1.18.1.2) 456 0.11301 non-essential 0.16463 non-essential high NA high_confidence_nonessential NP_217622.1 81.0 0.26174 63.988 Moderate candidate ESM-2 calibrated P(essential)=0.113; HANSEN integrated essentiality score=0.165; ProteomeLM contextual percentile=0.262; target-priority score=64.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 837 ML0481 P40834 ruvC ML0481 B1177_C3_226 Crossover junction endodeoxyribonuclease RuvC (EC 3.1.21.10) (Holliday junction nuclease RuvC) (Holliday junction resolvase RuvC) 188 0.08014 non-essential 0.16444 non-essential high NA high_confidence_nonessential NP_217110.1 81.5 0.40138 67.386 Strong candidate ESM-2 calibrated P(essential)=0.080; HANSEN integrated essentiality score=0.164; ProteomeLM contextual percentile=0.401; target-priority score=67.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 838 ML2123 Q50136 prrA ML2123 MLCB57.61c Transcriptional regulatory protein PrrA 233 0.07767 non-essential 0.16432 non-essential high NA high_confidence_nonessential NP_215418.1 95.7 0.43394 59.927 Moderate candidate ESM-2 calibrated P(essential)=0.078; HANSEN integrated essentiality score=0.164; ProteomeLM contextual percentile=0.434; target-priority score=59.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 839 ML0001 P46388 dnaA ML0001 Chromosomal replication initiator protein DnaA 502 0.14132 non-essential 0.1643 non-essential high NA high_confidence_nonessential NP_214515.1 85.0 0.16656 51.508 Moderate candidate ESM-2 calibrated P(essential)=0.141; HANSEN integrated essentiality score=0.164; ProteomeLM contextual percentile=0.167; target-priority score=51.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 840 ML2566 Q9CD22 ML2566 MaoC-like domain-containing protein 300 0.08446 non-essential 0.16416 non-essential high NA high_confidence_nonessential NP_214755.1 81.8 0.40326 59.467 Moderate candidate ESM-2 calibrated P(essential)=0.084; HANSEN integrated essentiality score=0.164; ProteomeLM contextual percentile=0.403; target-priority score=59.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 841 ML0335 Q9CCW1 ML0335 ABC-transporter transmembrane protein 286 0.00198 non-essential 0.16411 non-essential high NA high_confidence_nonessential NP_216576.1 77.3 0.75078 69.868 Strong candidate ESM-2 calibrated P(essential)=0.002; HANSEN integrated essentiality score=0.164; ProteomeLM contextual percentile=0.751; target-priority score=69.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 842 ML2081 Q7APZ2 pgsA2 ML2081 CDP-diacylglycerol-glycerol-3-phosphate 206 0.03954 non-essential 0.1641 non-essential high NA high_confidence_nonessential NP_216338.1 72.2 0.58109 68.941 Strong candidate ESM-2 calibrated P(essential)=0.040; HANSEN integrated essentiality score=0.164; ProteomeLM contextual percentile=0.581; target-priority score=68.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 843 ML1629 Q9CBT5 smc ML1629 MLCB250.01 Chromosome partition protein Smc 1203 0.152 non-essential 0.16399 non-essential high NA high_confidence_nonessential NP_217438.2 78.3 0.12148 49.563 Exploratory ESM-2 calibrated P(essential)=0.152; HANSEN integrated essentiality score=0.164; ProteomeLM contextual percentile=0.121; target-priority score=49.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:45Z 844 ML0071 Q9CDC7 ML0071 Peptidase 177 0.06199 non-essential 0.16392 non-essential high agree high_confidence_nonessential Rv3847 96.6 NE 0 0.89731 73.987 Strong candidate ESM-2 calibrated P(essential)=0.062; HANSEN integrated essentiality score=0.164; Mtb RBH anchor Rv3847=non-essential (agree); ProteomeLM contextual percentile=0.897; target-priority score=74.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 845 ML1589 Q9CBU1 cdsA ML1589 Phosphatidate cytidylyltransferase (EC 2.7.7.41) (CDP-diacylglycerol synthase) (CDP-DAG synthase) (CDP-DG synthase) (CDS) (CDP-diglyceride pyrophosphorylase) (CDP-diglyceride synthase) (CTP:phosphatidate cytidylyltransferase) 312 0.0332 non-essential 0.16383 non-essential high NA high_confidence_nonessential NP_217397.1 70.5 0.59111 74.889 Strong candidate ESM-2 calibrated P(essential)=0.033; HANSEN integrated essentiality score=0.164; ProteomeLM contextual percentile=0.591; target-priority score=74.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 846 ML2608 O06069 ilvD ML2608 MLCL622.06c Dihydroxy-acid dehydratase (DAD) (EC 4.2.1.9) 564 0.09373 non-essential 0.16354 non-essential high NA high_confidence_nonessential NP_214703.1 90.0 0.32937 68.878 Strong candidate ESM-2 calibrated P(essential)=0.094; HANSEN integrated essentiality score=0.164; ProteomeLM contextual percentile=0.329; target-priority score=68.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 847 ML0304 P57993 pknG ML0304 MLCB1450.19c Serine/threonine-protein kinase PknG (EC 2.7.11.1) 763 0.11803 non-essential 0.16342 non-essential high NA high_confidence_nonessential NP_214924.1 83.2 0.24233 60.321 Moderate candidate ESM-2 calibrated P(essential)=0.118; HANSEN integrated essentiality score=0.163; ProteomeLM contextual percentile=0.242; target-priority score=60.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 848 ML2136 O33062 serC ML2136 MLCB57.37c Putative phosphoserine aminotransferase (EC 2.6.1.52) (Phosphohydroxythreonine aminotransferase) (PSAT) 376 0.15423 non-essential 0.16319 non-essential high NA high_confidence_nonessential NP_215399.1 87.5 0.07326 60.869 Moderate candidate ESM-2 calibrated P(essential)=0.154; HANSEN integrated essentiality score=0.163; ProteomeLM contextual percentile=0.073; target-priority score=60.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 849 ML1526 Q9CBV7 ML1526 Conserved membrane protein 160 0.01172 non-essential 0.16313 non-essential high NA high_confidence_nonessential NP_217288.1 76.6 0.71071 66.349 Strong candidate ESM-2 calibrated P(essential)=0.012; HANSEN integrated essentiality score=0.163; ProteomeLM contextual percentile=0.711; target-priority score=66.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 850 ML1756 Q9CBP1 mmr ML1756 Multidrug resistance protein mmr 107 0.00543 non-essential 0.16303 non-essential high NA high_confidence_nonessential YP_177922.1 78.5 0.73513 67.652 Strong candidate ESM-2 calibrated P(essential)=0.005; HANSEN integrated essentiality score=0.163; ProteomeLM contextual percentile=0.735; target-priority score=67.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 851 ML1147 P53432 ML1147 u471b Uncharacterized protein ML1147 147 0.08377 non-essential 0.16295 non-essential high agree high_confidence_nonessential Rv1312 88.4 NE 0 0.7752 70.338 Strong candidate ESM-2 calibrated P(essential)=0.084; HANSEN integrated essentiality score=0.163; Mtb RBH anchor Rv1312=non-essential (agree); ProteomeLM contextual percentile=0.775; target-priority score=70.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 852 ML0909 O69557 murE ML0909 MLCB268.07c UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase (EC 6.3.2.13) (Meso-A2pm-adding enzyme) (Meso-diaminopimelate-adding enzyme) (UDP-MurNAc-L-Ala-D-Glu:meso-diaminopimelate ligase) (UDP-MurNAc-tripeptide synthetase) (UDP-N-acetylmuramyl-tripeptide synthetase) 530 0.04867 non-essential 0.16294 non-essential high NA high_confidence_nonessential NP_216674.1 74.4 0.50657 77.723 Strong candidate ESM-2 calibrated P(essential)=0.049; HANSEN integrated essentiality score=0.163; ProteomeLM contextual percentile=0.507; target-priority score=77.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 853 ML1730 Q9CBQ3 adhA ML1730 NADP-dependent alcohol dehydrogenase C (EC 1.1.1.2) 362 0.04985 non-essential 0.16286 non-essential high NA high_confidence_nonessential NP_217561.1 85.8 0.5216 70.611 Strong candidate ESM-2 calibrated P(essential)=0.050; HANSEN integrated essentiality score=0.163; ProteomeLM contextual percentile=0.522; target-priority score=70.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 854 ML2394 P46807 metB ML2394 Cystathionine gamma-synthase (CGS) (EC 2.5.1.48) (O-succinylhomoserine (thiol)-lyase) 388 0.14132 non-essential 0.16279 non-essential high NA high_confidence_nonessential NP_215595.1 87.3 0.14277 56.587 Moderate candidate ESM-2 calibrated P(essential)=0.141; HANSEN integrated essentiality score=0.163; ProteomeLM contextual percentile=0.143; target-priority score=56.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 855 ML1351 O05678 ML1351 MLC1351.17c Putative 3-methyladenine DNA glycosylase (EC 3.2.2.-) 214 0.02518 non-essential 0.16256 non-essential high NA high_confidence_nonessential NP_216204.1 78.3 0.63181 71.036 Strong candidate ESM-2 calibrated P(essential)=0.025; HANSEN integrated essentiality score=0.163; ProteomeLM contextual percentile=0.632; target-priority score=71.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 856 ML0733 Q9CCL2 ML0733 Membrane protein 172 0.01412 non-essential 0.16255 non-essential high NA high_confidence_nonessential NP_217795.1 83.1 0.69631 66.332 Strong candidate ESM-2 calibrated P(essential)=0.014; HANSEN integrated essentiality score=0.163; ProteomeLM contextual percentile=0.696; target-priority score=66.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 857 ML1921 Q9CBI9 ML1921 AB hydrolase-1 domain-containing protein 256 0.02734 non-essential 0.16243 non-essential high NA high_confidence_nonessential NP_218108.1 78.5 0.62993 68.02 Strong candidate ESM-2 calibrated P(essential)=0.027; HANSEN integrated essentiality score=0.162; ProteomeLM contextual percentile=0.630; target-priority score=68.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 858 ML1847 O32995 rplE ML1847 MLCB2492.16 Large ribosomal subunit protein uL5 (50S ribosomal protein L5) 187 0.13486 non-essential 0.16239 non-essential high NA high_confidence_nonessential NP_215230.1 92.0 0.18034 53.096 Moderate candidate ESM-2 calibrated P(essential)=0.135; HANSEN integrated essentiality score=0.162; ProteomeLM contextual percentile=0.180; target-priority score=53.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 859 ML1058 Q7AQ99 dapD ML1058 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase (EC 2.3.1.117) (Tetrahydrodipicolinate N-succinyltransferase) (THDP succinyltransferase) (THP succinyltransferase) (Tetrahydropicolinate succinylase) 317 0.10418 non-essential 0.16229 non-essential high NA high_confidence_nonessential NP_215717.1 85.2 0.28053 66.677 Strong candidate ESM-2 calibrated P(essential)=0.104; HANSEN integrated essentiality score=0.162; ProteomeLM contextual percentile=0.281; target-priority score=66.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 860 ML0753 Q9CCK6 rmlA2 ML0753 Sugar-phosphate nucleotidyl transferase 358 0.12506 non-essential 0.1621 non-essential high NA high_confidence_nonessential YP_177951.1 78.0 0.22167 53.739 Moderate candidate ESM-2 calibrated P(essential)=0.125; HANSEN integrated essentiality score=0.162; ProteomeLM contextual percentile=0.222; target-priority score=53.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 861 ML2640 Q9CCZ4 ML2640 Putative S-adenosyl-L-methionine-dependent methyltransferase ML2640 (EC 2.1.1.-) 310 0.01019 non-essential 0.16206 non-essential high NA high_confidence_nonessential NP_214660.1 78.1 0.68503 75.304 Strong candidate ESM-2 calibrated P(essential)=0.010; HANSEN integrated essentiality score=0.162; ProteomeLM contextual percentile=0.685; target-priority score=75.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 862 ML1427 Q7AQ51 ML1427 Possible ABC-transport lipoprotein 445 0.07317 non-essential 0.16205 non-essential high NA high_confidence_nonessential NP_216557.1 77.4 0.44709 57.934 Moderate candidate ESM-2 calibrated P(essential)=0.073; HANSEN integrated essentiality score=0.162; ProteomeLM contextual percentile=0.447; target-priority score=57.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 863 ML0324 Q9CCW4 ML0324 Uncharacterized tRNA/rRNA methyltransferase ML0324 (EC 2.1.1.-) 309 0.11185 non-essential 0.162 non-essential high NA high_confidence_nonessential NP_218096.1 84.4 0.26425 59.665 Moderate candidate ESM-2 calibrated P(essential)=0.112; HANSEN integrated essentiality score=0.162; ProteomeLM contextual percentile=0.264; target-priority score=59.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 864 ML1015 Q9CCB4 ML1015 Possible conserved membrane protein 139 0.00543 non-essential 0.16187 non-essential high NA high_confidence_nonessential NP_217225.1 75.2 0.73889 64.058 Moderate candidate ESM-2 calibrated P(essential)=0.005; HANSEN integrated essentiality score=0.162; ProteomeLM contextual percentile=0.739; target-priority score=64.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 865 ML1591 O33045 pyrH ML1591 MLCB250.75 Uridylate kinase (UK) (EC 2.7.4.22) (Uridine monophosphate kinase) (UMP kinase) (UMPK) 255 0.10115 non-essential 0.16167 non-essential high NA high_confidence_nonessential NP_217399.1 95.3 0.29242 66.123 Strong candidate ESM-2 calibrated P(essential)=0.101; HANSEN integrated essentiality score=0.162; ProteomeLM contextual percentile=0.292; target-priority score=66.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 866 ML1146 P45822 atpC ML1146 ATP synthase epsilon chain (ATP synthase F1 sector epsilon subunit) (F-ATPase epsilon subunit) 121 0.06652 non-essential 0.16108 non-essential high NA high_confidence_nonessential NP_215827.1 87.6 0.45711 62.965 Moderate candidate ESM-2 calibrated P(essential)=0.067; HANSEN integrated essentiality score=0.161; ProteomeLM contextual percentile=0.457; target-priority score=63.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 867 ML1063 P0C0X2 folP2 ML1063 Inactive dihydropteroate synthase 2 (DHPS 2) (Dihydropteroate pyrophosphorylase 2) 291 0.0733 non-essential 0.16079 non-essential high NA high_confidence_nonessential NP_215723.1 86.8 0.43018 60.964 Moderate candidate ESM-2 calibrated P(essential)=0.073; HANSEN integrated essentiality score=0.161; ProteomeLM contextual percentile=0.430; target-priority score=61.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 868 ML1669 O69462 ML1669 MLCB1243.03c Aldo-keto reductase ML1669 (EC 1.1.1.-) 282 0.05162 non-essential 0.16074 non-essential high NA high_confidence_nonessential NP_217487.1 82.4 0.50219 70.207 Strong candidate ESM-2 calibrated P(essential)=0.052; HANSEN integrated essentiality score=0.161; ProteomeLM contextual percentile=0.502; target-priority score=70.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 869 ML0589 Q7AQH9 ML0589 Membrane protein 265 0.00543 non-essential 0.1606 non-essential high NA high_confidence_nonessential NP_215973.1 83.1 0.7176 68.746 Strong candidate ESM-2 calibrated P(essential)=0.005; HANSEN integrated essentiality score=0.161; ProteomeLM contextual percentile=0.718; target-priority score=68.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 870 ML1702 O33105 gatA ML1702 MLCB637.13 Glutamyl-tRNA(Gln) amidotransferase subunit A (Glu-ADT subunit A) (EC 6.3.5.7) 497 0.13353 non-essential 0.16059 non-essential high NA high_confidence_nonessential NP_217527.2 89.0 0.15529 60.076 Moderate candidate ESM-2 calibrated P(essential)=0.134; HANSEN integrated essentiality score=0.161; ProteomeLM contextual percentile=0.155; target-priority score=60.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 871 ML0013 Q9CDE7 crgA ML0013 Cell division protein CrgA 93 0.08711 non-essential 0.16056 non-essential high NA high_confidence_nonessential NP_214525.1 89.2 0.38197 55.367 Moderate candidate ESM-2 calibrated P(essential)=0.087; HANSEN integrated essentiality score=0.161; ProteomeLM contextual percentile=0.382; target-priority score=55.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 872 ML2654 Q9CCZ0 ML2654 Phosphoesterase (EC 3.1.4.-) 165 0.13353 non-essential 0.16055 non-essential high NA high_confidence_nonessential 0.16907 55.325 Moderate candidate ESM-2 calibrated P(essential)=0.134; HANSEN integrated essentiality score=0.161; ProteomeLM contextual percentile=0.169; target-priority score=55.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 873 ML0005 Q59533 gyrB ML0005 DNA gyrase subunit B (EC 5.6.2.2) 678 0.13353 non-essential 0.1604 non-essential high NA high_confidence_nonessential NP_214519.2 86.5 0.1484 62.045 Moderate candidate ESM-2 calibrated P(essential)=0.134; HANSEN integrated essentiality score=0.160; ProteomeLM contextual percentile=0.148; target-priority score=62.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 874 ML0896 Q7AQD4 aroG ML0896 Phospho-2-dehydro-3-deoxyheptonate aldolase (EC 2.5.1.54) 462 0.09187 non-essential 0.16039 non-essential high NA high_confidence_nonessential NP_216694.1 89.7 0.32123 68.24 Strong candidate ESM-2 calibrated P(essential)=0.092; HANSEN integrated essentiality score=0.160; ProteomeLM contextual percentile=0.321; target-priority score=68.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 875 ML2046 Q9CBF2 lldD2 ML2046 Putative L-lactate dehydrogenase 414 0.04897 non-essential 0.16032 non-essential high NA high_confidence_nonessential NP_216388.1 85.0 0.51785 68.167 Strong candidate ESM-2 calibrated P(essential)=0.049; HANSEN integrated essentiality score=0.160; ProteomeLM contextual percentile=0.518; target-priority score=68.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 876 ML1151 P52982 ogt ML1151 Methylated-DNA--protein-cysteine methyltransferase (EC 2.1.1.63) (6-O-methylguanine-DNA methyltransferase) (MGMT) (O-6-methylguanine-DNA-alkyltransferase) 165 0.05192 non-essential 0.16013 non-essential high NA high_confidence_nonessential NP_215832.1 78.2 0.4953 70.861 Strong candidate ESM-2 calibrated P(essential)=0.052; HANSEN integrated essentiality score=0.160; ProteomeLM contextual percentile=0.495; target-priority score=70.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 877 ML2350 Q9CB71 ML2350 Transport permease protein 276 0.00228 non-essential 0.16007 non-essential high NA high_confidence_nonessential NP_217454.1 79.0 0.72761 69.203 Strong candidate ESM-2 calibrated P(essential)=0.002; HANSEN integrated essentiality score=0.160; ProteomeLM contextual percentile=0.728; target-priority score=69.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 878 ML2074 Q7APZ5 ML2074 BFN domain-containing protein 164 0.12863 non-essential 0.16003 non-essential high agree high_confidence_nonessential Rv1829 95.1 NE 0 0.52098 61.503 Moderate candidate ESM-2 calibrated P(essential)=0.129; HANSEN integrated essentiality score=0.160; Mtb RBH anchor Rv1829=non-essential (agree); ProteomeLM contextual percentile=0.521; target-priority score=61.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 879 ML1715 Q9CBR3 ML1715 Transferase 438 0.07471 non-essential 0.15966 non-essential high NA high_confidence_nonessential NP_217548.1 87.9 0.41954 60.139 Moderate candidate ESM-2 calibrated P(essential)=0.075; HANSEN integrated essentiality score=0.160; ProteomeLM contextual percentile=0.420; target-priority score=60.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 880 ML1481 Q9CBY2 tig ML1481 Trigger factor (TF) (EC 5.2.1.8) (PPIase) 469 0.05422 non-essential 0.15957 non-essential high NA high_confidence_nonessential NP_216978.1 71.4 0.48466 69.775 Strong candidate ESM-2 calibrated P(essential)=0.054; HANSEN integrated essentiality score=0.160; ProteomeLM contextual percentile=0.485; target-priority score=69.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 881 ML0644 Q9CCM6 ML0644 MLCB1779.46 UPF0182 protein ML0644 983 0.15503 non-essential 0.1589 non-essential high NA high_confidence_nonessential NP_217709.1 85.6 0.08766 46.15 Exploratory ESM-2 calibrated P(essential)=0.155; HANSEN integrated essentiality score=0.159; ProteomeLM contextual percentile=0.088; target-priority score=46.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:45Z 882 ML1638 Q9CBS9 ML1638 MLCB1243.37 Uncharacterized protein ML1638 232 0.05767 non-essential 0.15878 non-essential high agree high_confidence_nonessential Rv2229c 60.4 NE 0 0.88228 71.901 Strong candidate ESM-2 calibrated P(essential)=0.058; HANSEN integrated essentiality score=0.159; Mtb RBH anchor Rv2229c=non-essential (agree); ProteomeLM contextual percentile=0.882; target-priority score=71.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 883 ML1214 Q9CC67 ML1214 Secreted p60-family protein 212 0.09148 non-essential 0.15873 non-essential high agree high_confidence_nonessential Rv1566c 75.4 GA 0 0.70382 66.908 Strong candidate ESM-2 calibrated P(essential)=0.091; HANSEN integrated essentiality score=0.159; Mtb RBH anchor Rv1566c=non-essential (agree); ProteomeLM contextual percentile=0.704; target-priority score=66.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 884 ML0760 Q9CCK0 whiB2 whiB ML0760 Transcriptional regulator WhiB 89 0.00543 non-essential 0.15872 non-essential high NA high_confidence_nonessential NP_217777.1 86.5 0.69568 72.433 Strong candidate ESM-2 calibrated P(essential)=0.005; HANSEN integrated essentiality score=0.159; ProteomeLM contextual percentile=0.696; target-priority score=72.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 885 ML0921 Q9CCE0 ML0921 Possible membrane protein 96 0.01233 non-essential 0.1585 non-essential high NA high_confidence_nonessential NP_216662.1 89.6 0.6794 66.779 Strong candidate ESM-2 calibrated P(essential)=0.012; HANSEN integrated essentiality score=0.159; ProteomeLM contextual percentile=0.679; target-priority score=66.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 886 ML2072 O32915 gcvP gcvB ML2072 MLCB1788.32c Glycine dehydrogenase (decarboxylating) (EC 1.4.4.2) (Glycine cleavage system P-protein) (Glycine decarboxylase) (Glycine dehydrogenase (aminomethyl-transferring)) 952 0.15871 non-essential 0.15843 non-essential high NA high_confidence_nonessential NP_216348.1 85.0 0.04884 52.655 Moderate candidate ESM-2 calibrated P(essential)=0.159; HANSEN integrated essentiality score=0.158; ProteomeLM contextual percentile=0.049; target-priority score=52.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:45Z 887 ML0454 Q7AQI9 pgsA ML0454 Phosphatidylinositol phosphate synthase (PIP synthase) (EC 2.7.8.-) (CDP-diacylglycerol--D-myo-inositol-3-phosphate 3-phosphatidyltransferase) 239 0.01019 non-essential 0.15836 non-essential high NA high_confidence_nonessential YP_177894.1 79.3 0.64997 79.83 Strong candidate ESM-2 calibrated P(essential)=0.010; HANSEN integrated essentiality score=0.158; ProteomeLM contextual percentile=0.650; target-priority score=79.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 888 ML2534 Q9CD31 ML2534 PE-family protein 102 0.0 non-essential 0.15834 non-essential high NA high_confidence_nonessential YP_177710.1 73.0 0.7345 66.957 Strong candidate ESM-2 calibrated P(essential)=0.000; HANSEN integrated essentiality score=0.158; ProteomeLM contextual percentile=0.735; target-priority score=67.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 889 ML1044 Q50008 cgoX hemY ML1044 Coproporphyrinogen III oxidase (EC 1.3.3.15) 451 0.04818 non-essential 0.15826 non-essential high NA high_confidence_nonessential YP_177675.1 75.4 0.49092 74.443 Strong candidate ESM-2 calibrated P(essential)=0.048; HANSEN integrated essentiality score=0.158; ProteomeLM contextual percentile=0.491; target-priority score=74.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 890 ML1067 Q7AQ95 ML1067 DUF3117 domain-containing protein 75 0.04218 non-essential 0.15816 non-essential high agree high_confidence_nonessential Rv1211 90.7 NE 0 0.96306 73.085 Strong candidate ESM-2 calibrated P(essential)=0.042; HANSEN integrated essentiality score=0.158; Mtb RBH anchor Rv1211=non-essential (agree); ProteomeLM contextual percentile=0.963; target-priority score=73.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 891 ML0128 Q9CD88 ML0128 Glycosyl transferase 435 0.03172 non-essential 0.15805 non-essential high NA high_confidence_nonessential 0.59048 65.861 Strong candidate ESM-2 calibrated P(essential)=0.032; HANSEN integrated essentiality score=0.158; ProteomeLM contextual percentile=0.590; target-priority score=65.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 892 ML0213 O69538 tilS ML0213 MLCB2548.18c tRNA(Ile)-lysidine synthase (EC 6.3.4.19) (tRNA(Ile)-2-lysyl-cytidine synthase) (tRNA(Ile)-lysidine synthetase) 323 0.02795 non-essential 0.1578 non-essential high NA high_confidence_nonessential NP_218142.1 77.1 0.58297 73.789 Strong candidate ESM-2 calibrated P(essential)=0.028; HANSEN integrated essentiality score=0.158; ProteomeLM contextual percentile=0.583; target-priority score=73.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 893 ML1685 O33123 leuC ML1685 MLCB637.32 3-isopropylmalate dehydratase large subunit (EC 4.2.1.33) (Alpha-IPM isomerase) (IPMI) (Isopropylmalate isomerase) 476 0.04673 non-essential 0.15748 non-essential high NA high_confidence_nonessential NP_217504.1 88.7 0.49343 74.297 Strong candidate ESM-2 calibrated P(essential)=0.047; HANSEN integrated essentiality score=0.157; ProteomeLM contextual percentile=0.493; target-priority score=74.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 894 ML2390 Q9CB67 ML2390 Possible secreted protein 101 0.06768 non-essential 0.15708 non-essential high agree high_confidence_nonessential Rv1083 58.4 NE 0 0.83219 66.502 Strong candidate ESM-2 calibrated P(essential)=0.068; HANSEN integrated essentiality score=0.157; Mtb RBH anchor Rv1083=non-essential (agree); ProteomeLM contextual percentile=0.832; target-priority score=66.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 895 ML1066 Q7AQ96 tagA ML1066 DNA-3-methyladenine glycosidase I 192 0.01172 non-essential 0.15708 non-essential high NA high_confidence_nonessential NP_215726.1 80.7 0.66374 70.198 Strong candidate ESM-2 calibrated P(essential)=0.012; HANSEN integrated essentiality score=0.157; ProteomeLM contextual percentile=0.664; target-priority score=70.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 896 ML0824 Q9CCG6 furB ML0824 Zinc uptake regulation protein 131 0.00888 non-essential 0.15706 non-essential high NA high_confidence_nonessential NP_216875.1 84.6 0.67314 71.397 Strong candidate ESM-2 calibrated P(essential)=0.009; HANSEN integrated essentiality score=0.157; ProteomeLM contextual percentile=0.673; target-priority score=71.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 897 ML1101 Q9CC93 ML1101 Possible acyltransferase 379 0.03924 non-essential 0.1566 non-essential high NA high_confidence_nonessential NP_215770.1 79.4 0.55041 64.86 Moderate candidate ESM-2 calibrated P(essential)=0.039; HANSEN integrated essentiality score=0.157; ProteomeLM contextual percentile=0.550; target-priority score=64.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 898 ML0711 Q9CCL6 ML0711 Gamma-glutamylcyclotransferase 159 0.06543 non-essential 0.15632 non-essential high agree high_confidence_nonessential Rv3304 92.5 NE 0 0.79336 75.446 Strong candidate ESM-2 calibrated P(essential)=0.065; HANSEN integrated essentiality score=0.156; Mtb RBH anchor Rv3304=non-essential (agree); ProteomeLM contextual percentile=0.793; target-priority score=75.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 899 ML1657 Q7AQ32 ML1657 Acetyl/propionyl CoA carboxylase [beta] subunit 473 0.14132 non-essential 0.15624 non-essential high NA high_confidence_nonessential NP_216763.1 92.8 0.12649 49.022 Exploratory ESM-2 calibrated P(essential)=0.141; HANSEN integrated essentiality score=0.156; ProteomeLM contextual percentile=0.126; target-priority score=49.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 900 ML2684 P46390 ssb ML2684 MLCB1913.20c Single-stranded DNA-binding protein (SSB) 168 0.01648 non-essential 0.15613 non-essential high NA high_confidence_nonessential NP_214568.1 87.5 0.64809 66.194 Strong candidate ESM-2 calibrated P(essential)=0.016; HANSEN integrated essentiality score=0.156; ProteomeLM contextual percentile=0.648; target-priority score=66.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 901 ML1557 Q7AQ43 ML1557 YlxR domain-containing protein 106 0.08883 non-essential 0.15603 non-essential high agree high_confidence_nonessential Rv2840c 82.3 GA 0 0.70131 65.202 Strong candidate ESM-2 calibrated P(essential)=0.089; HANSEN integrated essentiality score=0.156; Mtb RBH anchor Rv2840c=non-essential (agree); ProteomeLM contextual percentile=0.701; target-priority score=65.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 902 ML1682 Q9CBR8 ML1682 Nudix hydrolase domain-containing protein 311 0.09638 non-essential 0.15602 non-essential high NA high_confidence_nonessential NP_217501.1 71.8 0.30996 56.302 Moderate candidate ESM-2 calibrated P(essential)=0.096; HANSEN integrated essentiality score=0.156; ProteomeLM contextual percentile=0.310; target-priority score=56.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 903 ML0985 Q7AQB9 ML0985 Possible glycosyltransferase 392 0.06636 non-essential 0.156 non-essential high NA high_confidence_nonessential NP_217255.1 80.9 0.43456 60.723 Moderate candidate ESM-2 calibrated P(essential)=0.066; HANSEN integrated essentiality score=0.156; ProteomeLM contextual percentile=0.435; target-priority score=60.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 904 ML0294 Q9ZBL0 thiC ML0294 MLCB1450.28c Phosphomethylpyrimidine synthase (EC 4.1.99.17) (Hydroxymethylpyrimidine phosphate synthase) (HMP-P synthase) (HMP-phosphate synthase) (HMPP synthase) (Thiamine biosynthesis protein ThiC) 547 0.14132 non-essential 0.15577 non-essential high NA high_confidence_nonessential NP_214937.1 90.6 0.08892 60.854 Moderate candidate ESM-2 calibrated P(essential)=0.141; HANSEN integrated essentiality score=0.156; ProteomeLM contextual percentile=0.089; target-priority score=60.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 905 ML0110 Q9CDA3 ML0110 Arabinogalactan biosynthesis recruiting protein ML0110 123 0.01757 non-essential 0.15575 non-essential high NA high_confidence_nonessential NP_218306.1 73.0 0.63118 69.481 Strong candidate ESM-2 calibrated P(essential)=0.018; HANSEN integrated essentiality score=0.156; ProteomeLM contextual percentile=0.631; target-priority score=69.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 906 ML2616 Q7APT0 ML2616 Uncharacterized protein 170 0.09638 non-essential 0.15574 non-essential high agree high_confidence_nonessential Rv0201c 62.1 NE 0 0.64934 65.959 Strong candidate ESM-2 calibrated P(essential)=0.096; HANSEN integrated essentiality score=0.156; Mtb RBH anchor Rv0201c=non-essential (agree); ProteomeLM contextual percentile=0.649; target-priority score=66.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 907 ML1484 Q9CBY1 rpiB ML1484 Ribose-5-phosphate isomerase B (EC 5.3.1.6) (Phosphoriboisomerase B) 162 0.01019 non-essential 0.15571 non-essential high NA high_confidence_nonessential YP_177884.1 89.5 0.63494 79.639 Strong candidate ESM-2 calibrated P(essential)=0.010; HANSEN integrated essentiality score=0.156; ProteomeLM contextual percentile=0.635; target-priority score=79.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 908 ML0243 Q9CD50 ML0243 Acyl-CoA synthetase 544 0.10358 non-essential 0.1556 non-essential high NA high_confidence_nonessential NP_215529.1 82.4 0.27677 55.51 Moderate candidate ESM-2 calibrated P(essential)=0.104; HANSEN integrated essentiality score=0.156; ProteomeLM contextual percentile=0.277; target-priority score=55.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 909 ML1488 Q9CBX8 ML1488 Aminotransferase (EC 2.6.1.-) 367 0.14338 non-essential 0.15553 non-essential high NA high_confidence_nonessential NP_215694.1 83.4 0.10144 52.909 Moderate candidate ESM-2 calibrated P(essential)=0.143; HANSEN integrated essentiality score=0.156; ProteomeLM contextual percentile=0.101; target-priority score=52.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 910 ML2082 O32922 secA2 ML2082 MLCB1788.45c Protein translocase subunit SecA 2 (EC 7.4.2.8) 778 0.10418 non-essential 0.15539 non-essential high NA high_confidence_nonessential NP_216337.1 87.1 0.25673 60.976 Moderate candidate ESM-2 calibrated P(essential)=0.104; HANSEN integrated essentiality score=0.155; ProteomeLM contextual percentile=0.257; target-priority score=61.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 911 ML0354 Q49865 ilvX ML0354 acetolactate synthase (EC 2.2.1.6) 515 0.06981 non-essential 0.15523 non-essential high NA high_confidence_nonessential NP_218026.1 83.1 0.39136 68.506 Strong candidate ESM-2 calibrated P(essential)=0.070; HANSEN integrated essentiality score=0.155; ProteomeLM contextual percentile=0.391; target-priority score=68.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 912 ML1959 Q9X7A0 rpsK ML1959 MLCB1222.29c Small ribosomal subunit protein uS11 (30S ribosomal protein S11) 138 0.14132 non-essential 0.15475 non-essential high NA high_confidence_nonessential NP_217976.1 89.9 0.11522 49.86 Exploratory ESM-2 calibrated P(essential)=0.141; HANSEN integrated essentiality score=0.155; ProteomeLM contextual percentile=0.115; target-priority score=49.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 913 ML0774 Q9CCJ1 mtrB ML0774 Sensor histidine kinase MtrB (EC 2.7.13.3) 562 0.10418 non-essential 0.15455 non-essential high NA high_confidence_nonessential NP_217762.1 91.4 0.26049 58.013 Moderate candidate ESM-2 calibrated P(essential)=0.104; HANSEN integrated essentiality score=0.155; ProteomeLM contextual percentile=0.260; target-priority score=58.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 914 ML1576 Q9CBU7 mapB map ML1576 Methionine aminopeptidase (MAP) (MetAP) (EC 3.4.11.18) (Peptidase M) 285 0.14132 non-essential 0.15452 non-essential high NA high_confidence_nonessential YP_177911.1 89.8 0.09142 57.5 Moderate candidate ESM-2 calibrated P(essential)=0.141; HANSEN integrated essentiality score=0.155; ProteomeLM contextual percentile=0.091; target-priority score=57.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 915 ML1269 Q9X7C5 trpE ML1269 MLCB1610.31 Anthranilate synthase component 1 (AS) (ASI) (EC 4.1.3.27) 529 0.08883 non-essential 0.15442 non-essential high NA high_confidence_nonessential NP_216125.1 88.2 0.30307 67.216 Strong candidate ESM-2 calibrated P(essential)=0.089; HANSEN integrated essentiality score=0.154; ProteomeLM contextual percentile=0.303; target-priority score=67.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 916 ML0489 Q49646 ML0489 B1177_C2_197 MLCB1259.07 Uncharacterized lipoprotein ML0489 555 0.13829 non-essential 0.15394 non-essential high NA high_confidence_nonessential NP_217101.1 79.0 0.12711 48.923 Exploratory ESM-2 calibrated P(essential)=0.138; HANSEN integrated essentiality score=0.154; ProteomeLM contextual percentile=0.127; target-priority score=48.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 917 ML1359 Q49897 nadK ML1359 MLC1351.13c NAD kinase (EC 2.7.1.23) (ATP-dependent NAD kinase) 311 0.09875 non-essential 0.1539 non-essential high NA high_confidence_nonessential NP_216211.1 87.9 0.26612 63.272 Moderate candidate ESM-2 calibrated P(essential)=0.099; HANSEN integrated essentiality score=0.154; ProteomeLM contextual percentile=0.266; target-priority score=63.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 918 ML1195 Q9X7E5 ileS ML1195 MLCB458.10 Isoleucine--tRNA ligase (EC 6.1.1.5) (Isoleucyl-tRNA synthetase) (IleRS) 1059 0.05604 non-essential 0.15371 non-essential high NA high_confidence_nonessential NP_216052.1 84.4 0.5 ESM-2 calibrated P(essential)=0.056; HANSEN integrated essentiality score=0.154; ProteomeLM contextual percentile=0.500 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:45Z 919 ML2663 Q7APS6 oxyS ML2663 Probable hydrogen peroxide-inducible genes activator 310 0.05241 non-essential 0.15368 non-essential high NA high_confidence_nonessential NP_214631.1 81.8 0.48215 61.673 Moderate candidate ESM-2 calibrated P(essential)=0.052; HANSEN integrated essentiality score=0.154; ProteomeLM contextual percentile=0.482; target-priority score=61.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 920 ML0082 Q9CDC1 serS ML0082 Serine--tRNA ligase (EC 6.1.1.11) (Seryl-tRNA synthetase) (SerRS) (Seryl-tRNA(Ser/Sec) synthetase) 417 0.04913 non-essential 0.15364 non-essential high NA high_confidence_nonessential NP_218351.1 86.1 0.45773 75.007 Strong candidate ESM-2 calibrated P(essential)=0.049; HANSEN integrated essentiality score=0.154; ProteomeLM contextual percentile=0.458; target-priority score=75.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 921 ML2627 Q7APS9 ML2627 Acyl dehydratase 339 0.07497 non-essential 0.15355 non-essential high NA high_confidence_nonessential NP_214730.1 73.7 0.39261 56.656 Moderate candidate ESM-2 calibrated P(essential)=0.075; HANSEN integrated essentiality score=0.154; ProteomeLM contextual percentile=0.393; target-priority score=56.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 922 ML0895 Q7AQD5 ML0895 3'-5' exoribonuclease (EC 3.1.13.-) 171 0.0 non-essential 0.15352 non-essential high NA high_confidence_nonessential NP_216695.1 83.1 0.68316 74.771 Strong candidate ESM-2 calibrated P(essential)=0.000; HANSEN integrated essentiality score=0.154; ProteomeLM contextual percentile=0.683; target-priority score=74.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 923 ML0597 Q7AQH4 ML0597 NIF system FeS cluster assembly NifU N-terminal domain-containing protein 165 0.09166 non-essential 0.15337 non-essential high NA high_confidence_nonessential NP_215981.1 79.4 0.31935 55.17 Moderate candidate ESM-2 calibrated P(essential)=0.092; HANSEN integrated essentiality score=0.153; ProteomeLM contextual percentile=0.319; target-priority score=55.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 924 ML0322 Q9CCW5 ispF ML0322 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase (MECDP-synthase) (MECPP-synthase) (MECPS) (EC 4.6.1.12) 158 0.0 non-essential 0.15336 non-essential high NA high_confidence_nonessential NP_218098.1 79.7 0.66312 81.256 High-priority ESM-2 calibrated P(essential)=0.000; HANSEN integrated essentiality score=0.153; ProteomeLM contextual percentile=0.663; target-priority score=81.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 925 ML0393 Q49741 ML0393 B1620_F3_119 Beta-phosphoglucomutase (Beta-PGM) (EC 5.4.2.6) 261 0.07935 non-essential 0.15331 non-essential high NA high_confidence_nonessential NP_217917.1 74.4 0.34565 65.319 Strong candidate ESM-2 calibrated P(essential)=0.079; HANSEN integrated essentiality score=0.153; ProteomeLM contextual percentile=0.346; target-priority score=65.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 926 ML2230 Q9CBC1 purB ML2230 Adenylosuccinate lyase (ASL) (EC 4.3.2.2) (Adenylosuccinase) 472 0.04818 non-essential 0.15331 non-essential high NA high_confidence_nonessential NP_215291.1 86.7 0.47151 71.154 Strong candidate ESM-2 calibrated P(essential)=0.048; HANSEN integrated essentiality score=0.153; ProteomeLM contextual percentile=0.472; target-priority score=71.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 927 ML2321 Q9CB79 ML2321 DUF4185 domain-containing protein 336 0.04552 non-essential 0.15324 non-essential high agree high_confidence_nonessential Rv3707c 81.6 NE 0 0.88791 74.275 Strong candidate ESM-2 calibrated P(essential)=0.046; HANSEN integrated essentiality score=0.153; Mtb RBH anchor Rv3707c=non-essential (agree); ProteomeLM contextual percentile=0.888; target-priority score=74.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 928 ML2141 Q7APY5 ML2141 DUF2530 domain-containing protein 91 0.04552 non-essential 0.15312 non-essential high NA high_confidence_nonessential NP_215394.1 76.9 0.52035 58.307 Moderate candidate ESM-2 calibrated P(essential)=0.046; HANSEN integrated essentiality score=0.153; ProteomeLM contextual percentile=0.520; target-priority score=58.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 929 ML0889 Q7AQE0 ML0889 Coenzyme Q-binding protein COQ10 START domain-containing protein 144 0.09677 non-essential 0.15288 non-essential high agree high_confidence_nonessential Rv2185c 85.4 NE 0 0.61866 65.898 Strong candidate ESM-2 calibrated P(essential)=0.097; HANSEN integrated essentiality score=0.153; Mtb RBH anchor Rv2185c=non-essential (agree); ProteomeLM contextual percentile=0.619; target-priority score=65.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 930 ML2260 Q50173 pit pitA ML2260 Probable low-affinity inorganic phosphate transporter 414 0.01172 non-essential 0.15275 non-essential high NA high_confidence_nonessential NP_215059.1 76.6 0.64308 68.568 Strong candidate ESM-2 calibrated P(essential)=0.012; HANSEN integrated essentiality score=0.153; ProteomeLM contextual percentile=0.643; target-priority score=68.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 931 ML2314 Q9CB81 glpK ML2314 Glycerol kinase (EC 2.7.1.30) (ATP:glycerol 3-phosphotransferase) (Glycerokinase) (GK) 508 0.03604 non-essential 0.15264 non-essential high NA high_confidence_nonessential NP_218213.1 91.3 0.51158 75.126 Strong candidate ESM-2 calibrated P(essential)=0.036; HANSEN integrated essentiality score=0.153; ProteomeLM contextual percentile=0.512; target-priority score=75.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 932 ML2536 Q9CD29 ML2536 Conserved membrane protein 552 0.11185 non-essential 0.1525 non-essential high NA high_confidence_nonessential NP_214797.1 70.8 0.22918 52.587 Moderate candidate ESM-2 calibrated P(essential)=0.112; HANSEN integrated essentiality score=0.152; ProteomeLM contextual percentile=0.229; target-priority score=52.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 933 ML0875 Q9CCF1 ctaC ML0875 Probable cytochrome c oxidase subunit 2 (EC 7.1.1.9) (Cytochrome aa3 subunit 2) (Cytochrome c oxidase polypeptide II) 353 0.07168 non-essential 0.15237 non-essential high NA high_confidence_nonessential NP_216716.1 82.6 0.3732 66.032 Strong candidate ESM-2 calibrated P(essential)=0.072; HANSEN integrated essentiality score=0.152; ProteomeLM contextual percentile=0.373; target-priority score=66.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 934 ML1175 P52063 ML1175 B1549_C2_213 MLCB1701.01 dITP/XTP pyrophosphatase (EC 3.6.1.66) (Non-canonical purine NTP pyrophosphatase) (Non-standard purine NTP pyrophosphatase) (Nucleoside-triphosphate diphosphatase) (Nucleoside-triphosphate pyrophosphatase) (NTPase) 208 0.02734 non-essential 0.1523 non-essential high NA high_confidence_nonessential NP_215857.1 82.9 0.55667 72.679 Strong candidate ESM-2 calibrated P(essential)=0.027; HANSEN integrated essentiality score=0.152; ProteomeLM contextual percentile=0.557; target-priority score=72.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 935 ML1218 P45486 bioD ML1218 B1170_C1_159 ATP-dependent dethiobiotin synthetase BioD (EC 6.3.3.3) (DTB synthetase) (DTBS) (Dethiobiotin synthase) 226 0.02518 non-essential 0.15212 non-essential high NA high_confidence_nonessential NP_216086.1 74.7 0.55103 77.609 Strong candidate ESM-2 calibrated P(essential)=0.025; HANSEN integrated essentiality score=0.152; ProteomeLM contextual percentile=0.551; target-priority score=77.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 936 ML1947 Q7AQ14 fum fumC ML1947 Fumarate hydratase class II (Fumarase C) (EC 4.2.1.2) (Aerobic fumarase) (Iron-independent fumarase) 474 0.01889 non-essential 0.15211 non-essential high NA high_confidence_nonessential NP_215614.1 89.5 0.58046 77.406 Strong candidate ESM-2 calibrated P(essential)=0.019; HANSEN integrated essentiality score=0.152; ProteomeLM contextual percentile=0.580; target-priority score=77.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 937 ML0119 Q9CD95 lipE ML0119 Probable hydrolase 411 0.07935 non-essential 0.15189 non-essential high NA high_confidence_nonessential NP_218292.1 84.7 0.35755 58.433 Moderate candidate ESM-2 calibrated P(essential)=0.079; HANSEN integrated essentiality score=0.152; ProteomeLM contextual percentile=0.358; target-priority score=58.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 938 ML0815 Q9CCH0 ML0815 TetR-family transcriptional regulator 228 0.02975 non-essential 0.15155 non-essential high NA high_confidence_nonessential NP_217724.1 82.4 0.56606 64.221 Moderate candidate ESM-2 calibrated P(essential)=0.030; HANSEN integrated essentiality score=0.152; ProteomeLM contextual percentile=0.566; target-priority score=64.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 939 ML1134 P45833 prfA ML1134 Peptide chain release factor 1 (RF-1) 361 0.03424 non-essential 0.15151 non-essential high NA high_confidence_nonessential NP_215815.1 89.4 0.54853 63.1 Moderate candidate ESM-2 calibrated P(essential)=0.034; HANSEN integrated essentiality score=0.152; ProteomeLM contextual percentile=0.549; target-priority score=63.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 940 ML0494 P46696 hisS ML0494 B1177_C3_248 MLCB1259.12 Histidine--tRNA ligase (EC 6.1.1.21) (Histidyl-tRNA synthetase) (HisRS) 427 0.06636 non-essential 0.15138 non-essential high NA high_confidence_nonessential NP_217096.1 85.9 0.39011 66.611 Strong candidate ESM-2 calibrated P(essential)=0.066; HANSEN integrated essentiality score=0.151; ProteomeLM contextual percentile=0.390; target-priority score=66.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 941 ML1423 Q7AQ55 ML1423 PNPLA domain-containing protein 329 0.03424 non-essential 0.15104 non-essential high NA high_confidence_nonessential NP_216553.1 80.5 0.53726 66.001 Strong candidate ESM-2 calibrated P(essential)=0.034; HANSEN integrated essentiality score=0.151; ProteomeLM contextual percentile=0.537; target-priority score=66.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 942 ML2140 O33060 ML2140 MLCB57.31 Uncharacterized HTH-type transcriptional regulator ML2140 143 0.01747 non-essential 0.15104 non-essential high NA high_confidence_nonessential NP_215395.1 90.2 0.61302 66.401 Strong candidate ESM-2 calibrated P(essential)=0.017; HANSEN integrated essentiality score=0.151; ProteomeLM contextual percentile=0.613; target-priority score=66.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 943 ML2358 Q7APV7 fadD26 ML2358 Probable acyl-CoA synthase 583 0.09148 non-essential 0.15095 non-essential high NA high_confidence_nonessential NP_217446.2 76.8 0.30056 56.997 Moderate candidate ESM-2 calibrated P(essential)=0.091; HANSEN integrated essentiality score=0.151; ProteomeLM contextual percentile=0.301; target-priority score=57.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 944 ML0517 Q9CCS5 aroK ML0517 Shikimate kinase (SK) (EC 2.7.1.71) 199 0.02105 non-essential 0.15072 non-essential high NA high_confidence_nonessential NP_217055.1 79.6 0.56731 75.715 Strong candidate ESM-2 calibrated P(essential)=0.021; HANSEN integrated essentiality score=0.151; ProteomeLM contextual percentile=0.567; target-priority score=75.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 945 ML1740 Q9CBP7 ML1740 Possible short chain reductase 312 0.07126 non-essential 0.1507 non-essential high NA high_confidence_nonessential NP_217573.1 81.8 0.3876 58.453 Moderate candidate ESM-2 calibrated P(essential)=0.071; HANSEN integrated essentiality score=0.151; ProteomeLM contextual percentile=0.388; target-priority score=58.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 946 ML0997 Q9CCC0 hflX ML0997 GTPase HflX (GTP-binding protein HflX) 488 0.13353 non-essential 0.1506 non-essential high NA high_confidence_nonessential NP_217241.1 84.5 0.12336 50.965 Moderate candidate ESM-2 calibrated P(essential)=0.134; HANSEN integrated essentiality score=0.151; ProteomeLM contextual percentile=0.123; target-priority score=51.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 947 ML0087 Q9CDC0 ML0087 Acyltransferase 257 0.03769 non-essential 0.1505 non-essential high NA high_confidence_nonessential NP_218333.1 82.1 0.52348 64.215 Moderate candidate ESM-2 calibrated P(essential)=0.038; HANSEN integrated essentiality score=0.150; ProteomeLM contextual percentile=0.523; target-priority score=64.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 948 ML0772 Q9CCJ3 tmk ML0772 Thymidylate kinase (EC 2.7.4.9) (dTMP kinase) 210 0.01019 non-essential 0.15048 non-essential high NA high_confidence_nonessential NP_217764.1 77.8 0.62304 73.237 Strong candidate ESM-2 calibrated P(essential)=0.010; HANSEN integrated essentiality score=0.150; ProteomeLM contextual percentile=0.623; target-priority score=73.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 949 ML0109 Q9CDA4 ML0109 FAD-linked oxidoreductase 460 0.05949 non-essential 0.15044 non-essential high NA high_confidence_nonessential NP_218307.1 86.6 0.43331 60.749 Moderate candidate ESM-2 calibrated P(essential)=0.059; HANSEN integrated essentiality score=0.150; ProteomeLM contextual percentile=0.433; target-priority score=60.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 950 ML2131 O33065 pdxH ML2131 MLCB57.46 Pyridoxine/pyridoxamine 5'-phosphate oxidase (EC 1.4.3.5) (PNP/PMP oxidase) (PNPOx) (Pyridoxal 5'-phosphate synthase) 219 0.0303 non-essential 0.15035 non-essential high NA high_confidence_nonessential NP_217123.1 67.1 0.52411 75.231 Strong candidate ESM-2 calibrated P(essential)=0.030; HANSEN integrated essentiality score=0.150; ProteomeLM contextual percentile=0.524; target-priority score=75.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 951 ML2303 Q9CB90 ML2303 Hydrolase 262 0.09148 non-essential 0.15019 non-essential high NA high_confidence_nonessential NP_218194.1 82.1 0.29806 56.328 Moderate candidate ESM-2 calibrated P(essential)=0.091; HANSEN integrated essentiality score=0.150; ProteomeLM contextual percentile=0.298; target-priority score=56.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 952 ML1485 Q9CBY0 ML1485 Uncharacterized protein 207 0.07065 non-essential 0.14966 non-essential high agree high_confidence_nonessential Rv2466c 80.6 NE 0 0.73262 68.015 Strong candidate ESM-2 calibrated P(essential)=0.071; HANSEN integrated essentiality score=0.150; Mtb RBH anchor Rv2466c=non-essential (agree); ProteomeLM contextual percentile=0.733; target-priority score=68.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 953 ML1768 Q9CBN8 uspA ML1768 Sugar transport integral membrane protein 328 0.02581 non-essential 0.14941 non-essential high NA high_confidence_nonessential NP_216832.1 83.5 0.57608 62.69 Moderate candidate ESM-2 calibrated P(essential)=0.026; HANSEN integrated essentiality score=0.149; ProteomeLM contextual percentile=0.576; target-priority score=62.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 954 ML0637 P53528 uvrD2 ML0637 B1937_F1_27 ATP-dependent DNA helicase UvrD2 (EC 5.6.2.4) (DNA 3'-5' helicase UvrD2) 714 0.0667 non-essential 0.14939 non-essential high NA high_confidence_nonessential NP_217714.1 82.9 0.37884 65.933 Strong candidate ESM-2 calibrated P(essential)=0.067; HANSEN integrated essentiality score=0.149; ProteomeLM contextual percentile=0.379; target-priority score=65.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 955 ML1511 Q9CBW6 cobB ML1511 NAD-dependent protein deacylase (EC 2.3.1.286) (Regulatory protein SIR2 homolog) 237 0.02734 non-essential 0.14937 non-essential high NA high_confidence_nonessential NP_215667.1 85.2 0.53663 73.639 Strong candidate ESM-2 calibrated P(essential)=0.027; HANSEN integrated essentiality score=0.149; ProteomeLM contextual percentile=0.537; target-priority score=73.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 956 ML1128 Q50140 lysA ML1128 Diaminopimelate decarboxylase (DAP decarboxylase) (DAPDC) (EC 4.1.1.20) 472 0.03424 non-essential 0.14916 non-essential high NA high_confidence_nonessential NP_215809.1 86.8 0.50157 74.382 Strong candidate ESM-2 calibrated P(essential)=0.034; HANSEN integrated essentiality score=0.149; ProteomeLM contextual percentile=0.502; target-priority score=74.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 957 ML0803 Q9CCH8 ML0803 histidine kinase (EC 2.7.13.3) 500 0.0905 non-essential 0.14914 non-essential high NA high_confidence_nonessential NP_217736.1 81.8 0.28616 59.813 Moderate candidate ESM-2 calibrated P(essential)=0.091; HANSEN integrated essentiality score=0.149; ProteomeLM contextual percentile=0.286; target-priority score=59.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 958 ML0877 Q9CCE9 mmpS3 ML0877 Probable transport accessory protein MmpS3 293 0.01648 non-essential 0.14905 non-essential high NA high_confidence_nonessential NP_216714.1 66.7 0.62054 61.414 Moderate candidate ESM-2 calibrated P(essential)=0.016; HANSEN integrated essentiality score=0.149; ProteomeLM contextual percentile=0.621; target-priority score=61.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 959 ML1029 Q7AQA7 ML1029 DUF3710 domain-containing protein 273 0.08883 non-essential 0.14863 non-essential high agree high_confidence_nonessential Rv2696c 67.9 NE 0 0.6387 62.914 Moderate candidate ESM-2 calibrated P(essential)=0.089; HANSEN integrated essentiality score=0.149; Mtb RBH anchor Rv2696c=non-essential (agree); ProteomeLM contextual percentile=0.639; target-priority score=62.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 960 ML0778 Q9CCI7 hpf ML0778 Ribosome hibernation promoting factor (HPF) 229 0.05604 non-essential 0.14846 non-essential high agree high_confidence_nonessential Rv3241c 89.3 GA 0 0.79086 71.493 Strong candidate ESM-2 calibrated P(essential)=0.056; HANSEN integrated essentiality score=0.148; Mtb RBH anchor Rv3241c=non-essential (agree); ProteomeLM contextual percentile=0.791; target-priority score=71.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 961 ML1116 Q9CC86 ML1116 Lipoprotein 187 0.03424 non-essential 0.14846 non-essential high NA high_confidence_nonessential NP_215791.1 82.7 0.54039 59.767 Moderate candidate ESM-2 calibrated P(essential)=0.034; HANSEN integrated essentiality score=0.148; ProteomeLM contextual percentile=0.540; target-priority score=59.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 962 ML0297 Q9ZBL2 thiG ML0297 MLCB1450.26 Thiazole synthase (EC 2.8.1.10) 261 0.09928 non-essential 0.14836 non-essential high NA high_confidence_nonessential NP_214931.1 87.2 0.2248 65.428 Strong candidate ESM-2 calibrated P(essential)=0.099; HANSEN integrated essentiality score=0.148; ProteomeLM contextual percentile=0.225; target-priority score=65.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 963 ML1681 O33127 ppk ML1681 MLCB637.36c Polyphosphate kinase (EC 2.7.4.1) (ATP-polyphosphate phosphotransferase) (Polyphosphoric acid kinase) 739 0.10418 non-essential 0.14827 non-essential high NA high_confidence_nonessential NP_217500.1 87.9 0.2154 60.794 Moderate candidate ESM-2 calibrated P(essential)=0.104; HANSEN integrated essentiality score=0.148; ProteomeLM contextual percentile=0.215; target-priority score=60.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 964 ML0174 Q9CD68 mprA ML0174 MLCB373.26 Response regulator MprA (Mycobacterial persistence regulator A) 228 0.06309 non-essential 0.14816 non-essential high NA high_confidence_nonessential NP_215496.2 94.3 0.41077 58.24 Moderate candidate ESM-2 calibrated P(essential)=0.063; HANSEN integrated essentiality score=0.148; ProteomeLM contextual percentile=0.411; target-priority score=58.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 965 ML0118 Q9CD96 ML0118 Oxidireductase 336 0.06199 non-essential 0.14813 non-essential high NA high_confidence_nonessential NP_218294.1 76.0 0.40701 61.181 Moderate candidate ESM-2 calibrated P(essential)=0.062; HANSEN integrated essentiality score=0.148; ProteomeLM contextual percentile=0.407; target-priority score=61.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 966 ML1410 Q9CC11 argF ML1410 Ornithine carbamoyltransferase (OTCase) (EC 2.1.3.3) 306 0.09148 non-essential 0.14812 non-essential high NA high_confidence_nonessential NP_216172.1 84.0 0.25736 66.019 Strong candidate ESM-2 calibrated P(essential)=0.091; HANSEN integrated essentiality score=0.148; ProteomeLM contextual percentile=0.257; target-priority score=66.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 967 ML1094 Q9CC98 ML1094 Short chain alcohol dehydrogenase 277 0.07126 non-essential 0.14804 non-essential high NA high_confidence_nonessential NP_215761.1 78.7 0.37132 58.674 Moderate candidate ESM-2 calibrated P(essential)=0.071; HANSEN integrated essentiality score=0.148; ProteomeLM contextual percentile=0.371; target-priority score=58.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 968 ML1244 Q7AQ82 ML1244 Diacylglycerol O-acyltransferase (EC 2.3.1.20) 491 0.06981 non-essential 0.14794 non-essential high NA high_confidence_nonessential NP_217000.1 75.2 0.35379 66.697 Strong candidate ESM-2 calibrated P(essential)=0.070; HANSEN integrated essentiality score=0.148; ProteomeLM contextual percentile=0.354; target-priority score=66.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 969 ML1221 Q49616 bsaP ML1221 B1170_C1_162 Biotin synthase auxiliary protein 80 0.08711 non-essential 0.14792 non-essential high agree high_confidence_nonessential Rv1590 67.1 NE 0 0.62743 65.834 Strong candidate ESM-2 calibrated P(essential)=0.087; HANSEN integrated essentiality score=0.148; Mtb RBH anchor Rv1590=non-essential (agree); ProteomeLM contextual percentile=0.627; target-priority score=65.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 970 ML0660 Q7AQG9 fadE23 ML0660 Acyl-CoA dehydrogenase 400 0.1045 non-essential 0.14791 non-essential high NA high_confidence_nonessential NP_217656.1 89.5 0.2273 55.508 Moderate candidate ESM-2 calibrated P(essential)=0.105; HANSEN integrated essentiality score=0.148; ProteomeLM contextual percentile=0.227; target-priority score=55.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 971 ML0873 Q9CCF3 ML0873 Carbohydrate kinase 324 0.1283 non-essential 0.14789 non-essential high NA high_confidence_nonessential NP_216718.1 83.6 0.13212 50.724 Moderate candidate ESM-2 calibrated P(essential)=0.128; HANSEN integrated essentiality score=0.148; ProteomeLM contextual percentile=0.132; target-priority score=50.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 972 ML0634 P38119 uppS ML0634 B1937_F2_65 Decaprenyl diphosphate synthase (DecaPP) (EC 2.5.1.86) (EC 2.5.1.87) (Decaprenyl pyrophosphate synthase) (Long-chain isoprenyl diphosphate synthase) (Trans,polycis-decaprenyl diphosphate synthase) 296 0.09481 non-essential 0.14749 non-essential high NA high_confidence_nonessential NP_216877.1 88.2 0.24859 62.556 Moderate candidate ESM-2 calibrated P(essential)=0.095; HANSEN integrated essentiality score=0.147; ProteomeLM contextual percentile=0.249; target-priority score=62.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 973 ML0627 Q49751 ML0627 B1937_F1_20 PhoH-like protein 349 0.15557 non-essential 0.14744 non-essential high NA high_confidence_nonessential YP_177874.1 89.2 0.01691 46.429 Exploratory ESM-2 calibrated P(essential)=0.156; HANSEN integrated essentiality score=0.147; ProteomeLM contextual percentile=0.017; target-priority score=46.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 974 ML0674 O32879 folD ML0674 Bifunctional protein FolD [Includes: Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)] 282 0.14132 non-essential 0.14739 non-essential high NA high_confidence_nonessential NP_217873.1 86.8 0.04133 60.275 Moderate candidate ESM-2 calibrated P(essential)=0.141; HANSEN integrated essentiality score=0.147; ProteomeLM contextual percentile=0.041; target-priority score=60.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 975 ML0893 Q7AQD6 ML0893 Probable conserved integral membrane protein 428 0.00543 non-essential 0.14704 non-essential high NA high_confidence_nonessential NP_216697.1 80.1 0.64058 67.807 Strong candidate ESM-2 calibrated P(essential)=0.005; HANSEN integrated essentiality score=0.147; ProteomeLM contextual percentile=0.641; target-priority score=67.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 976 ML0300 Q9ZBL5 thiE ML0300 MLCB1450.23c Thiamine-phosphate synthase (TP synthase) (TPS) (EC 2.5.1.3) (Thiamine-phosphate pyrophosphorylase) (TMP pyrophosphorylase) (TMP-PPase) 235 0.02105 non-essential 0.14701 non-essential high NA high_confidence_nonessential NP_214928.1 78.7 0.54227 76.803 Strong candidate ESM-2 calibrated P(essential)=0.021; HANSEN integrated essentiality score=0.147; ProteomeLM contextual percentile=0.542; target-priority score=76.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 977 ML1278 Q9CC48 tesB ML1278 Acyl CoA thioesterase II 297 0.01172 non-essential 0.14681 non-essential high NA high_confidence_nonessential NP_216134.1 85.1 0.61177 67.345 Strong candidate ESM-2 calibrated P(essential)=0.012; HANSEN integrated essentiality score=0.147; ProteomeLM contextual percentile=0.612; target-priority score=67.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 978 ML0280 O69595 purA ML0280 MLCB4.23c Adenylosuccinate synthetase (AMPSase) (AdSS) (EC 6.3.4.4) (IMP--aspartate ligase) 432 0.06278 non-essential 0.1468 non-essential high NA high_confidence_nonessential NP_214871.1 87.9 0.37007 69.846 Strong candidate ESM-2 calibrated P(essential)=0.063; HANSEN integrated essentiality score=0.147; ProteomeLM contextual percentile=0.370; target-priority score=69.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 979 ML0572 P46711 tpiA tpi ML0572 B1496_C1_127 Triosephosphate isomerase (TIM) (TPI) (EC 5.3.1.1) (Triose-phosphate isomerase) 261 0.1316 non-essential 0.14669 non-essential high NA high_confidence_nonessential NP_215954.1 84.3 0.08203 60.199 Moderate candidate ESM-2 calibrated P(essential)=0.132; HANSEN integrated essentiality score=0.147; ProteomeLM contextual percentile=0.082; target-priority score=60.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 980 ML2268 Q9CBB2 menC ML2268 o-succinylbenzoate synthase (OSB synthase) (OSBS) (EC 4.2.1.113) (4-(2'-carboxyphenyl)-4-oxybutyric acid synthase) (o-succinylbenzoic acid synthase) 334 0.056 non-essential 0.14665 non-essential high NA high_confidence_nonessential NP_215067.1 79.5 0.39512 71.611 Strong candidate ESM-2 calibrated P(essential)=0.056; HANSEN integrated essentiality score=0.147; ProteomeLM contextual percentile=0.395; target-priority score=71.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 981 ML2066 O32912 guaB1 ML2066 MLCB1788.20 GMP reductase (EC 1.7.1.7) (Guanosine 5'-monophosphate reductase) (GMPR) 478 0.14132 non-essential 0.14646 non-essential high NA high_confidence_nonessential NP_216359.1 86.4 0.03945 59.043 Moderate candidate ESM-2 calibrated P(essential)=0.141; HANSEN integrated essentiality score=0.146; ProteomeLM contextual percentile=0.039; target-priority score=59.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 982 ML1995 Q9CBG2 ML1995 Carrier domain-containing protein 78 0.05001 non-essential 0.14645 non-essential high agree high_confidence_nonessential Rv0100 69.0 NE 0 0.81215 70.453 Strong candidate ESM-2 calibrated P(essential)=0.050; HANSEN integrated essentiality score=0.146; Mtb RBH anchor Rv0100=non-essential (agree); ProteomeLM contextual percentile=0.812; target-priority score=70.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 983 ML2263 Q9CBB5 menB ML2263 1,4-dihydroxy-2-naphthoyl-CoA synthase (DHNA-CoA synthase) (EC 4.1.3.36) 300 0.13353 non-essential 0.14635 non-essential high NA high_confidence_nonessential NP_215062.1 93.0 0.07201 59.922 Moderate candidate ESM-2 calibrated P(essential)=0.134; HANSEN integrated essentiality score=0.146; ProteomeLM contextual percentile=0.072; target-priority score=59.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 984 ML0108 Q9CDA5 ML0108 Oxidoreductase 254 0.09638 non-essential 0.14634 non-essential high NA high_confidence_nonessential NP_218308.1 89.0 0.25798 54.612 Moderate candidate ESM-2 calibrated P(essential)=0.096; HANSEN integrated essentiality score=0.146; ProteomeLM contextual percentile=0.258; target-priority score=54.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 985 ML1504 Q9CBX0 ML1504 Probable conserved membrane protein 430 0.00543 non-essential 0.14628 non-essential high NA high_confidence_nonessential NP_215675.1 77.1 0.63682 67.566 Strong candidate ESM-2 calibrated P(essential)=0.005; HANSEN integrated essentiality score=0.146; ProteomeLM contextual percentile=0.637; target-priority score=67.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 986 ML1198 Q9X7E6 ansA ML1198 MLCB458.13c L-asparaginase (L-ASNase) (EC 3.5.1.1) (L-asparagine amidohydrolase) 310 0.04964 non-essential 0.14615 non-essential high NA high_confidence_nonessential NP_216054.1 72.1 0.42893 69.031 Strong candidate ESM-2 calibrated P(essential)=0.050; HANSEN integrated essentiality score=0.146; ProteomeLM contextual percentile=0.429; target-priority score=69.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 987 ML2000 P46840 ctpB ML2000 Cation-transporting P-type ATPase B (EC 7.2.2.-) 750 0.03079 non-essential 0.14609 non-essential high NA high_confidence_nonessential NP_214617.1 75.1 0.51221 69.997 Strong candidate ESM-2 calibrated P(essential)=0.031; HANSEN integrated essentiality score=0.146; ProteomeLM contextual percentile=0.512; target-priority score=70.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 988 ML0193 Q9CD60 rsmI ML0193 Ribosomal RNA small subunit methyltransferase I (EC 2.1.1.198) (16S rRNA 2'-O-ribose C1402 methyltransferase) (rRNA (cytidine-2'-O-)-methyltransferase RsmI) 281 0.05368 non-essential 0.14561 non-essential high NA high_confidence_nonessential NP_215519.1 74.0 0.41515 66.335 Strong candidate ESM-2 calibrated P(essential)=0.054; HANSEN integrated essentiality score=0.146; ProteomeLM contextual percentile=0.415; target-priority score=66.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 989 ML1150 P45821 murA murZ ML1150 UDP-N-acetylglucosamine 1-carboxyvinyltransferase (EC 2.5.1.7) (Enoylpyruvate transferase) (UDP-N-acetylglucosamine enolpyruvyl transferase) (EPT) 418 0.13685 non-essential 0.14513 non-essential high NA high_confidence_nonessential NP_215831.1 96.2 0.04258 62.294 Moderate candidate ESM-2 calibrated P(essential)=0.137; HANSEN integrated essentiality score=0.145; ProteomeLM contextual percentile=0.043; target-priority score=62.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 990 ML1755 Q9CBP2 sdaA ML1755 L-serine dehydratase (EC 4.3.1.17) 458 0.0515 non-essential 0.14508 non-essential high NA high_confidence_nonessential NP_214583.1 69.0 0.41453 68.884 Strong candidate ESM-2 calibrated P(essential)=0.051; HANSEN integrated essentiality score=0.145; ProteomeLM contextual percentile=0.415; target-priority score=68.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 991 ML0731 P53002 accD5 pccB ML0731 B1308_C1_125 Biotin-dependent acetyl-/propionyl-coenzyme A carboxylase beta5 subunit (Acetyl-CoA carboxylase) (ACC) (EC 2.1.3.15) (Propionyl-CoA carboxylase) (PCC) (EC 2.1.3.-) 549 0.14132 non-essential 0.14507 non-essential high NA high_confidence_nonessential NP_217797.1 88.7 0.03569 57.547 Moderate candidate ESM-2 calibrated P(essential)=0.141; HANSEN integrated essentiality score=0.145; ProteomeLM contextual percentile=0.036; target-priority score=57.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 992 ML2289 Q9CB99 ML2289 Fido domain-containing protein 256 0.07168 non-essential 0.14501 non-essential high agree high_confidence_nonessential Rv3662c 78.4 NE 0 0.68629 66.752 Strong candidate ESM-2 calibrated P(essential)=0.072; HANSEN integrated essentiality score=0.145; Mtb RBH anchor Rv3662c=non-essential (agree); ProteomeLM contextual percentile=0.686; target-priority score=66.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 993 ML1274 Q9CC52 lgt ML1274 Phosphatidylglycerol--prolipoprotein diacylglyceryl transferase (EC 2.5.1.145) 330 0.03079 non-essential 0.14498 non-essential high NA high_confidence_nonessential NP_216130.1 78.7 0.49781 72.664 Strong candidate ESM-2 calibrated P(essential)=0.031; HANSEN integrated essentiality score=0.145; ProteomeLM contextual percentile=0.498; target-priority score=72.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 994 ML2324 Q9CB76 leuA ML2324 MLCB2407.26c 2-isopropylmalate synthase (EC 2.3.3.13) (Alpha-IPM synthase) (Alpha-isopropylmalate synthase) 607 0.14132 non-essential 0.14484 non-essential high NA high_confidence_nonessential NP_218227.3 80.9 0.03319 57.93 Moderate candidate ESM-2 calibrated P(essential)=0.141; HANSEN integrated essentiality score=0.145; ProteomeLM contextual percentile=0.033; target-priority score=57.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 995 ML2320 Q9CB80 ML2320 PknH-like extracellular domain-containing protein 215 0.04656 non-essential 0.14476 non-essential high agree high_confidence_nonessential Rv3705c 79.8 NE 0 0.8134 70.966 Strong candidate ESM-2 calibrated P(essential)=0.047; HANSEN integrated essentiality score=0.145; Mtb RBH anchor Rv3705c=non-essential (agree); ProteomeLM contextual percentile=0.813; target-priority score=71.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 996 ML0176 Q9CD67 ML0176 Possible secreted serine protease 382 0.05001 non-essential 0.1445 non-essential high NA high_confidence_nonessential NP_215498.1 77.8 0.44521 59.611 Moderate candidate ESM-2 calibrated P(essential)=0.050; HANSEN integrated essentiality score=0.144; ProteomeLM contextual percentile=0.445; target-priority score=59.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 997 ML1358 Q7AQ61 tlyA ML1358 Cytotoxin/hemolysin 269 0.04983 non-essential 0.14433 non-essential high NA high_confidence_nonessential NP_216210.1 78.7 0.44145 60.824 Moderate candidate ESM-2 calibrated P(essential)=0.050; HANSEN integrated essentiality score=0.144; ProteomeLM contextual percentile=0.441; target-priority score=60.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 998 ML2485 Q9CB29 ML2485 Possible RNA methyltransferase 182 0.02734 non-essential 0.14428 non-essential high NA high_confidence_nonessential NP_214894.1 88.5 0.5335 64.507 Moderate candidate ESM-2 calibrated P(essential)=0.027; HANSEN integrated essentiality score=0.144; ProteomeLM contextual percentile=0.534; target-priority score=64.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 999 ML0386 Q49742 ML0386 B1620_F3_131 Uncharacterized protein ML0386 137 0.03604 non-essential 0.14425 non-essential high agree high_confidence_nonessential Rv3412 94.1 NE 0 0.87163 70.927 Strong candidate ESM-2 calibrated P(essential)=0.036; HANSEN integrated essentiality score=0.144; Mtb RBH anchor Rv3412=non-essential (agree); ProteomeLM contextual percentile=0.872; target-priority score=70.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1000 ML0078 Q9CDC4 pheA ML0078 Prephenate dehydratase (PDT) (EC 4.2.1.51) 322 0.03203 non-essential 0.14421 non-essential high NA high_confidence_nonessential NP_218355.1 83.9 0.4928 70.906 Strong candidate ESM-2 calibrated P(essential)=0.032; HANSEN integrated essentiality score=0.144; ProteomeLM contextual percentile=0.493; target-priority score=70.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1001 ML0908 Q7AQC5 pbpB ML0908 Penicillin-binding protein 2 675 0.14132 non-essential 0.1442 non-essential high NA high_confidence_nonessential NP_216679.1 80.4 0.06262 46.651 Exploratory ESM-2 calibrated P(essential)=0.141; HANSEN integrated essentiality score=0.144; ProteomeLM contextual percentile=0.063; target-priority score=46.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1002 ML0012 Q9CDE8 ML0012 Membrane protein 137 0.02279 non-essential 0.14406 non-essential high NA high_confidence_nonessential NP_214524.1 71.5 0.56168 61.599 Moderate candidate ESM-2 calibrated P(essential)=0.023; HANSEN integrated essentiality score=0.144; ProteomeLM contextual percentile=0.562; target-priority score=61.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1003 ML1452 Q9CC00 ML1452 Possible phosphoglycerate mutase 224 0.07589 non-essential 0.14405 non-essential high NA high_confidence_nonessential NP_216935.1 80.4 0.32749 58.376 Moderate candidate ESM-2 calibrated P(essential)=0.076; HANSEN integrated essentiality score=0.144; ProteomeLM contextual percentile=0.327; target-priority score=58.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1004 ML1226 Q49617 nadB ML1226 B1170_C1_167 L-aspartate oxidase (LASPO) (EC 1.4.3.16) (Quinolinate synthase B) 526 0.07497 non-essential 0.14405 non-essential high NA high_confidence_nonessential NP_216111.1 76.7 0.29994 69.161 Strong candidate ESM-2 calibrated P(essential)=0.075; HANSEN integrated essentiality score=0.144; ProteomeLM contextual percentile=0.300; target-priority score=69.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1005 ML0898 Q7AQD2 ML0898 DNA-binding protein 134 0.09625 non-essential 0.14403 non-essential high NA high_confidence_nonessential NP_216691.1 81.3 0.24922 53.19 Moderate candidate ESM-2 calibrated P(essential)=0.096; HANSEN integrated essentiality score=0.144; ProteomeLM contextual percentile=0.249; target-priority score=53.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1006 ML2426 Q49807 cmaA2 ML2426 B2168_F3_130 Cyclopropane mycolic acid synthase 2 (CMAS) (EC 2.1.1.79) (Cyclopropane-fatty-acyl-phospholipid synthase) (CFA synthase) (Cyclopropane fatty acid synthase) (Mycolic acid methyltransferase) (MA-MT) (S-adenosylmethionine-dependent methyltransferase) (AdoMet-MT) (SAM-MT) 308 0.09148 non-essential 0.1439 non-essential high NA high_confidence_nonessential NP_215017.1 80.6 0.22981 66.942 Strong candidate ESM-2 calibrated P(essential)=0.091; HANSEN integrated essentiality score=0.144; ProteomeLM contextual percentile=0.230; target-priority score=66.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1007 ML0662 Q7AQG7 ML0662 Histidinol-phosphatase (EC 3.1.3.15) 255 0.08446 non-essential 0.1439 non-essential high NA high_confidence_nonessential NP_217653.1 81.8 0.26362 66.421 Strong candidate ESM-2 calibrated P(essential)=0.084; HANSEN integrated essentiality score=0.144; ProteomeLM contextual percentile=0.264; target-priority score=66.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1008 ML0577 P38388 secG ML0577 B1496_C3_206 Probable protein-export membrane protein SecG 77 0.07987 non-essential 0.14382 non-essential high NA high_confidence_nonessential NP_215956.2 96.1 0.32624 52.115 Moderate candidate ESM-2 calibrated P(essential)=0.080; HANSEN integrated essentiality score=0.144; ProteomeLM contextual percentile=0.326; target-priority score=52.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1009 ML2346 Q49942 ML2346 Methyltransferase FkbM domain-containing protein 301 0.03424 non-essential 0.14382 non-essential high NA high_confidence_nonessential 0.5072 61.78 Moderate candidate ESM-2 calibrated P(essential)=0.034; HANSEN integrated essentiality score=0.144; ProteomeLM contextual percentile=0.507; target-priority score=61.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1010 ML0561 Q9CCP2 ML0561 Membrane protein 156 0.0998 non-essential 0.14344 non-essential high NA high_confidence_nonessential NP_215933.1 60.1 0.23732 50.504 Moderate candidate ESM-2 calibrated P(essential)=0.100; HANSEN integrated essentiality score=0.143; ProteomeLM contextual percentile=0.237; target-priority score=50.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1011 ML1704 Q9CBR7 ML1704 ACT domain-containing protein 232 0.09148 non-essential 0.14303 non-essential high agree high_confidence_nonessential Rv3013 84.3 GA 0 0.57358 61.566 Moderate candidate ESM-2 calibrated P(essential)=0.091; HANSEN integrated essentiality score=0.143; Mtb RBH anchor Rv3013=non-essential (agree); ProteomeLM contextual percentile=0.574; target-priority score=61.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1012 ML0371 P40831 glmS ML0371 B229_C3_238 Glutamine--fructose-6-phosphate aminotransferase [isomerizing] (EC 2.6.1.16) (D-fructose-6-phosphate amidotransferase) (GFAT) (Glucosamine-6-phosphate synthase) (Hexosephosphate aminotransferase) (L-glutamine--D-fructose-6-phosphate amidotransferase) 625 0.13898 non-essential 0.14296 non-essential high NA high_confidence_nonessential NP_217953.1 89.3 0.04195 54.848 Moderate candidate ESM-2 calibrated P(essential)=0.139; HANSEN integrated essentiality score=0.143; ProteomeLM contextual percentile=0.042; target-priority score=54.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1013 ML2678 Q7APS1 ML2678 Transglutaminase-like domain-containing protein 1000 0.02105 non-essential 0.14291 non-essential high agree high_confidence_nonessential Rv2566 54.4 NE 0 0.94177 72.194 Strong candidate ESM-2 calibrated P(essential)=0.021; HANSEN integrated essentiality score=0.143; Mtb RBH anchor Rv2566=non-essential (agree); ProteomeLM contextual percentile=0.942; target-priority score=72.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:45Z 1014 ML0418 Q7AQJ5 ML0418 Oxidoreductase 210 0.07935 non-essential 0.14289 non-essential high NA high_confidence_nonessential NP_217885.1 81.4 0.30933 56.835 Moderate candidate ESM-2 calibrated P(essential)=0.079; HANSEN integrated essentiality score=0.143; ProteomeLM contextual percentile=0.309; target-priority score=56.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1015 ML0661 Q7AQG8 fadE24 ML0661 Acyl-CoA dehydrogenase 465 0.13829 non-essential 0.14283 non-essential high NA high_confidence_nonessential NP_217655.1 83.6 0.06763 46.927 Exploratory ESM-2 calibrated P(essential)=0.138; HANSEN integrated essentiality score=0.143; ProteomeLM contextual percentile=0.068; target-priority score=46.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1016 ML2451 Q9CB45 deoC ML2451 Deoxyribose-phosphate aldolase (DERA) (EC 4.1.2.4) (2-deoxy-D-ribose 5-phosphate aldolase) (Phosphodeoxyriboaldolase) (Deoxyriboaldolase) 226 0.0733 non-essential 0.14259 non-essential high NA high_confidence_nonessential NP_214992.1 78.3 0.30244 67.993 Strong candidate ESM-2 calibrated P(essential)=0.073; HANSEN integrated essentiality score=0.143; ProteomeLM contextual percentile=0.302; target-priority score=68.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1017 ML1694 O33114 ilvC ML1694 MLCB637.22 Ketol-acid reductoisomerase (NADP(+)) (KARI) (EC 1.1.1.86) (Acetohydroxy-acid isomeroreductase) (AHIR) (Alpha-keto-beta-hydroxylacyl reductoisomerase) (Ketol-acid reductoisomerase type 1) (Ketol-acid reductoisomerase type I) 333 0.14132 non-essential 0.14257 non-essential high NA high_confidence_nonessential NP_217517.3 86.5 0.01816 58.512 Moderate candidate ESM-2 calibrated P(essential)=0.141; HANSEN integrated essentiality score=0.143; ProteomeLM contextual percentile=0.018; target-priority score=58.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1018 ML2687 Q7APR9 ML2687 Conserved membrane protein 564 0.02691 non-essential 0.14251 non-essential high NA high_confidence_nonessential NP_214565.1 78.5 0.52661 63.989 Moderate candidate ESM-2 calibrated P(essential)=0.027; HANSEN integrated essentiality score=0.143; ProteomeLM contextual percentile=0.527; target-priority score=64.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1019 ML1583 Q9CBU3 dxr ML1583 1-deoxy-D-xylulose 5-phosphate reductoisomerase (DXP reductoisomerase) (EC 1.1.1.267) (1-deoxyxylulose-5-phosphate reductoisomerase) (2-C-methyl-D-erythritol 4-phosphate synthase) 406 0.02638 non-essential 0.1425 non-essential high NA high_confidence_nonessential NP_217386.2 83.1 0.49405 75.859 Strong candidate ESM-2 calibrated P(essential)=0.026; HANSEN integrated essentiality score=0.142; ProteomeLM contextual percentile=0.494; target-priority score=75.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1020 ML1953 Q9X794 glyA ML1953 MLCB1222.22 Serine hydroxymethyltransferase (SHMT) (Serine methylase) (EC 2.1.2.1) 426 0.10418 non-essential 0.14231 non-essential high NA high_confidence_nonessential YP_177787.3 89.9 0.17032 64.203 Moderate candidate ESM-2 calibrated P(essential)=0.104; HANSEN integrated essentiality score=0.142; ProteomeLM contextual percentile=0.170; target-priority score=64.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1021 ML0862 Q7AQE6 ephD ML0862 Oxidoreductase 596 0.07471 non-essential 0.14222 non-essential high NA high_confidence_nonessential NP_216730.1 80.4 0.32561 57.187 Moderate candidate ESM-2 calibrated P(essential)=0.075; HANSEN integrated essentiality score=0.142; ProteomeLM contextual percentile=0.326; target-priority score=57.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1022 ML1365 Q49890 xerD ML1365 MLC1351.07c u0247d Tyrosine recombinase XerD 316 0.14132 non-essential 0.14207 non-essential high NA high_confidence_nonessential NP_216217.1 85.4 0.04696 47.715 Exploratory ESM-2 calibrated P(essential)=0.141; HANSEN integrated essentiality score=0.142; ProteomeLM contextual percentile=0.047; target-priority score=47.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1023 ML2334 Q9CB74 ML2334 Polyketide synthase-like methyltransferase domain-containing protein 420 0.09148 non-essential 0.14203 non-essential high NA high_confidence_nonessential NP_218237.3 86.4 0.25548 54.478 Moderate candidate ESM-2 calibrated P(essential)=0.091; HANSEN integrated essentiality score=0.142; ProteomeLM contextual percentile=0.255; target-priority score=54.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1024 ML0639 Q49765 whiB7 whiB ML0639 Transcriptional regulator WhiB 89 0.00543 non-essential 0.14193 non-essential high NA high_confidence_nonessential YP_177940.1 68.1 0.60989 68.018 Strong candidate ESM-2 calibrated P(essential)=0.005; HANSEN integrated essentiality score=0.142; ProteomeLM contextual percentile=0.610; target-priority score=68.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1025 ML0543 Q9CCQ5 dfp coaBC ML0543 Coenzyme A biosynthesis bifunctional protein CoaBC (DNA/pantothenate metabolism flavoprotein) (Phosphopantothenoylcysteine synthetase/decarboxylase) (PPCS-PPCDC) [Includes: Phosphopantothenoylcysteine decarboxylase (PPC decarboxylase) (PPC-DC) (EC 4.1.1.36) (CoaC); Phosphopantothenate--cysteine ligase (EC 6.3.2.5) (CoaB) (Phosphopantothenoylcysteine synthetase) (PPC synthetase) (PPC-S)] 419 0.10725 non-essential 0.14177 non-essential high NA high_confidence_nonessential NP_215907.1 87.0 0.15654 62.994 Moderate candidate ESM-2 calibrated P(essential)=0.107; HANSEN integrated essentiality score=0.142; ProteomeLM contextual percentile=0.157; target-priority score=63.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1026 ML2332 Q7APW4 ML2332 Polyketide cyclase 145 0.05192 non-essential 0.14161 non-essential high agree high_confidence_nonessential Rv3718c 81.9 NE 0 0.7583 69.267 Strong candidate ESM-2 calibrated P(essential)=0.052; HANSEN integrated essentiality score=0.142; Mtb RBH anchor Rv3718c=non-essential (agree); ProteomeLM contextual percentile=0.758; target-priority score=69.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1027 ML0838 Q7AQF4 cysE ML0838 Serine acetyltransferase (EC 2.3.1.30) 227 0.04552 non-essential 0.14145 non-essential high NA high_confidence_nonessential NP_216851.1 76.4 0.42329 67.964 Strong candidate ESM-2 calibrated P(essential)=0.046; HANSEN integrated essentiality score=0.141; ProteomeLM contextual percentile=0.423; target-priority score=68.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1028 ML1794 Q9CBM9 ML1794 Putative cystathionine beta-lyase (CBL) (EC 4.4.1.13) (Beta-cystathionase) (Cysteine lyase) (Cysteine-S-conjugate beta-lyase) 402 0.02795 non-essential 0.14139 non-essential high NA high_confidence_nonessential NP_216810.1 76.2 0.49155 72.046 Strong candidate ESM-2 calibrated P(essential)=0.028; HANSEN integrated essentiality score=0.141; ProteomeLM contextual percentile=0.492; target-priority score=72.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1029 ML1139 P45829 atpB ML1139 ATP synthase subunit a (ATP synthase F0 sector subunit a) (F-ATPase subunit 6) 251 0.00198 non-essential 0.14123 non-essential high NA high_confidence_nonessential NP_215820.1 84.0 0.62492 66.889 Strong candidate ESM-2 calibrated P(essential)=0.002; HANSEN integrated essentiality score=0.141; ProteomeLM contextual percentile=0.625; target-priority score=66.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1030 ML2700 Q9CCX9 ML2700 Possible conserved membrane protein 1206 0.08711 non-essential 0.14119 non-essential high NA high_confidence_nonessential NP_218427.1 73.5 0.28178 50.691 Moderate candidate ESM-2 calibrated P(essential)=0.087; HANSEN integrated essentiality score=0.141; ProteomeLM contextual percentile=0.282; target-priority score=50.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:45Z 1031 ML1246 Q9X7B0 plsB ML1246 MLCB1610.07 Glycerol-3-phosphate acyltransferase (GPAT) (EC 2.3.1.15) 775 0.1277 non-essential 0.14091 non-essential high NA high_confidence_nonessential NP_216998.1 80.8 0.07514 57.053 Moderate candidate ESM-2 calibrated P(essential)=0.128; HANSEN integrated essentiality score=0.141; ProteomeLM contextual percentile=0.075; target-priority score=57.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1032 ML1372 Q49884 der engA ML1372 MLCB1351.01 u0247e GTPase Der (GTP-binding protein EngA) 461 0.1084 non-essential 0.14087 non-essential high NA high_confidence_nonessential NP_216229.1 88.8 0.17846 51.958 Moderate candidate ESM-2 calibrated P(essential)=0.108; HANSEN integrated essentiality score=0.141; ProteomeLM contextual percentile=0.178; target-priority score=52.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1033 ML0533 Q9CCR4 pyrC ML0533 Dihydroorotase (DHOase) (EC 3.5.2.3) 430 0.08711 non-essential 0.1408 non-essential high NA high_confidence_nonessential NP_215897.1 88.8 0.23544 65.665 Strong candidate ESM-2 calibrated P(essential)=0.087; HANSEN integrated essentiality score=0.141; ProteomeLM contextual percentile=0.235; target-priority score=65.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1034 ML0180 Q9CD66 ML0180 Putative regulatory protein FmdB zinc ribbon domain-containing protein 99 0.04553 non-essential 0.14078 non-essential high agree high_confidence_nonessential Rv0991c 90.6 NE 0 0.80401 66.13 Strong candidate ESM-2 calibrated P(essential)=0.046; HANSEN integrated essentiality score=0.141; Mtb RBH anchor Rv0991c=non-essential (agree); ProteomeLM contextual percentile=0.804; target-priority score=66.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1035 ML0094 Q9CDB6 ML0094 Membrane protein 192 0.01019 non-essential 0.1406 non-essential high NA high_confidence_nonessential NP_218324.1 73.8 0.58673 65.811 Strong candidate ESM-2 calibrated P(essential)=0.010; HANSEN integrated essentiality score=0.141; ProteomeLM contextual percentile=0.587; target-priority score=65.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1036 ML0019 Q50186 rodA ML0019 Peptidoglycan glycosyltransferase RodA (EC 2.4.99.28) (Non-canonical transglycosylase RodA) 465 0.09823 non-essential 0.14057 non-essential high NA high_confidence_nonessential NP_214531.1 82.3 0.1891 63.615 Moderate candidate ESM-2 calibrated P(essential)=0.098; HANSEN integrated essentiality score=0.141; ProteomeLM contextual percentile=0.189; target-priority score=63.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1037 ML1383 Q50178 coaE ML1383 o410 Dephospho-CoA kinase (EC 2.7.1.24) (Dephosphocoenzyme A kinase) 410 0.09148 non-essential 0.14039 non-essential high NA high_confidence_nonessential NP_216147.1 77.5 0.21415 65.246 Strong candidate ESM-2 calibrated P(essential)=0.091; HANSEN integrated essentiality score=0.140; ProteomeLM contextual percentile=0.214; target-priority score=65.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1038 ML1232 Q9CC62 ML1232 PE-PPE domain-containing protein 358 0.04386 non-essential 0.14038 non-essential high agree high_confidence_nonessential Rv1184c 62.7 NE 0 0.79023 70.072 Strong candidate ESM-2 calibrated P(essential)=0.044; HANSEN integrated essentiality score=0.140; Mtb RBH anchor Rv1184c=non-essential (agree); ProteomeLM contextual percentile=0.790; target-priority score=70.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1039 ML1798 Q9CBM8 ML1798 Kinase 327 0.08819 non-essential 0.14024 non-essential high NA high_confidence_nonessential NP_216012.1 83.0 0.26111 54.109 Moderate candidate ESM-2 calibrated P(essential)=0.088; HANSEN integrated essentiality score=0.140; ProteomeLM contextual percentile=0.261; target-priority score=54.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1040 ML2205 Q9CBC2 purM ML2205 Phosphoribosylformylglycinamidine cyclo-ligase (EC 6.3.3.1) (AIR synthase) (AIRS) (Phosphoribosyl-aminoimidazole synthetase) 364 0.05912 non-essential 0.14019 non-essential high NA high_confidence_nonessential NP_215324.1 87.1 0.35692 66.805 Strong candidate ESM-2 calibrated P(essential)=0.059; HANSEN integrated essentiality score=0.140; ProteomeLM contextual percentile=0.357; target-priority score=66.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1041 ML1677 Q9CBS1 ML1677 Possible secreted protein 191 0.06981 non-essential 0.14001 non-essential high agree high_confidence_nonessential Rv2980 67.3 NE 0 0.65811 64.625 Moderate candidate ESM-2 calibrated P(essential)=0.070; HANSEN integrated essentiality score=0.140; Mtb RBH anchor Rv2980=non-essential (agree); ProteomeLM contextual percentile=0.658; target-priority score=64.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1042 ML0995 P46811 miaA ML0995 B2235_C3_232 tRNA dimethylallyltransferase (EC 2.5.1.75) (Dimethylallyl diphosphate:tRNA dimethylallyltransferase) (DMAPP:tRNA dimethylallyltransferase) (DMATase) (Isopentenyl-diphosphate:tRNA isopentenyltransferase) (IPP transferase) (IPPT) (IPTase) 311 0.06199 non-essential 0.14 non-essential high NA high_confidence_nonessential NP_217243.1 82.2 0.34627 65.576 Strong candidate ESM-2 calibrated P(essential)=0.062; HANSEN integrated essentiality score=0.140; ProteomeLM contextual percentile=0.346; target-priority score=65.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1043 ML1630 Q9CBT4 glnE ML1630 Bifunctional glutamine synthetase adenylyltransferase/adenylyl-removing enzyme (ATP:glutamine synthetase adenylyltransferase) (ATase) [Includes: Glutamine synthetase adenylyl-L-tyrosine phosphorylase (EC 2.7.7.89) (Adenylyl removase) (AR) (AT-N); Glutamine synthetase adenylyl transferase (EC 2.7.7.42) (Adenylyl transferase) (AT) (AT-C)] 1004 0.10418 non-essential 0.13991 non-essential high NA high_confidence_nonessential NP_216737.1 82.1 0.17909 56.409 Moderate candidate ESM-2 calibrated P(essential)=0.104; HANSEN integrated essentiality score=0.140; ProteomeLM contextual percentile=0.179; target-priority score=56.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:45Z 1044 ML2452 Q9CB44 ML2452 Uncharacterized protein ML2452 123 0.01019 non-essential 0.13981 non-essential high agree high_confidence_nonessential Rv0477 60.0 GA 0 0.96368 74.659 Strong candidate ESM-2 calibrated P(essential)=0.010; HANSEN integrated essentiality score=0.140; Mtb RBH anchor Rv0477=non-essential (agree); ProteomeLM contextual percentile=0.964; target-priority score=74.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1045 ML0375 P38056 alr ML0375 B229_C3_243 Alanine racemase (EC 5.1.1.1) 388 0.03731 non-essential 0.13948 non-essential high NA high_confidence_nonessential NP_217940.1 84.4 0.43143 74.069 Strong candidate ESM-2 calibrated P(essential)=0.037; HANSEN integrated essentiality score=0.139; ProteomeLM contextual percentile=0.431; target-priority score=74.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1046 ML1519 Q9CBW0 thyA ML1519 Thymidylate synthase (TS) (TSase) (EC 2.1.1.45) 266 0.03466 non-essential 0.13939 non-essential high NA high_confidence_nonessential NP_217280.1 85.5 0.44396 73.763 Strong candidate ESM-2 calibrated P(essential)=0.035; HANSEN integrated essentiality score=0.139; ProteomeLM contextual percentile=0.444; target-priority score=73.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1047 ML0100 Q9CDB2 fadD32 ML0100 Acyl-AMP synthetase 635 0.09638 non-essential 0.13935 non-essential high NA high_confidence_nonessential NP_218318.1 93.0 0.20789 57.659 Moderate candidate ESM-2 calibrated P(essential)=0.096; HANSEN integrated essentiality score=0.139; ProteomeLM contextual percentile=0.208; target-priority score=57.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1048 ML0911 O69555 mraY murX ML0911 MLCB268.05c Phospho-N-acetylmuramoyl-pentapeptide-transferase (EC 2.7.8.13) (UDP-MurNAc-pentapeptide phosphotransferase) 359 0.08276 non-essential 0.13935 non-essential high NA high_confidence_nonessential NP_216672.1 91.1 0.2417 67.418 Strong candidate ESM-2 calibrated P(essential)=0.083; HANSEN integrated essentiality score=0.139; ProteomeLM contextual percentile=0.242; target-priority score=67.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1049 ML0686 Q49901 trpS ML0686 L308_C1_147 Tryptophan--tRNA ligase (EC 6.1.1.2) (Tryptophanyl-tRNA synthetase) (TrpRS) 343 0.03769 non-essential 0.1392 non-essential high NA high_confidence_nonessential NP_217853.1 83.8 0.4377 70.795 Strong candidate ESM-2 calibrated P(essential)=0.038; HANSEN integrated essentiality score=0.139; ProteomeLM contextual percentile=0.438; target-priority score=70.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1050 ML0079 Q9CDC3 ML0079 Phosphoglycerate mutase 231 0.05949 non-essential 0.13913 non-essential high NA high_confidence_nonessential NP_218354.1 71.6 0.37758 57.067 Moderate candidate ESM-2 calibrated P(essential)=0.059; HANSEN integrated essentiality score=0.139; ProteomeLM contextual percentile=0.378; target-priority score=57.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1051 ML1003 Q49848 lexA ML1003 B2235_F2_55 LexA repressor (EC 3.4.21.88) 235 0.09615 non-essential 0.13889 non-essential high NA high_confidence_nonessential NP_217236.2 84.5 0.19787 60.517 Moderate candidate ESM-2 calibrated P(essential)=0.096; HANSEN integrated essentiality score=0.139; ProteomeLM contextual percentile=0.198; target-priority score=60.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1052 ML2095 Q9CBE5 pstS2 phoS2 ML2095 Phosphate-binding protein PstS 3 (PBP 3) (PstS-3) 369 0.01648 non-essential 0.13887 non-essential high NA high_confidence_nonessential YP_177768.1 77.6 0.54915 65.32 Strong candidate ESM-2 calibrated P(essential)=0.016; HANSEN integrated essentiality score=0.139; ProteomeLM contextual percentile=0.549; target-priority score=65.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1053 ML1750 Q9CBP6 ML1750 Uncharacterized protein 623 0.05798 non-essential 0.13877 non-essential high agree high_confidence_nonessential Rv1354c 63.3 NE 0 0.70883 66.2 Strong candidate ESM-2 calibrated P(essential)=0.058; HANSEN integrated essentiality score=0.139; Mtb RBH anchor Rv1354c=non-essential (agree); ProteomeLM contextual percentile=0.709; target-priority score=66.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1054 ML2594 Q9CD09 mce1F ML2594 Secreted protein 516 0.03949 non-essential 0.13864 non-essential high NA high_confidence_nonessential NP_214688.1 76.5 0.46963 56.001 Moderate candidate ESM-2 calibrated P(essential)=0.039; HANSEN integrated essentiality score=0.139; ProteomeLM contextual percentile=0.470; target-priority score=56.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1055 ML1052 Q9CCB1 ML1052 Transcriptional regulator 421 0.13997 non-essential 0.13862 non-essential high agree high_confidence_nonessential Rv1194c 70.1 NE 0 0.28428 52.41 Moderate candidate ESM-2 calibrated P(essential)=0.140; HANSEN integrated essentiality score=0.139; Mtb RBH anchor Rv1194c=non-essential (agree); ProteomeLM contextual percentile=0.284; target-priority score=52.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1056 ML1808 Q9CBL9 ML1808 UPF0353 protein ML1808 335 0.14132 non-essential 0.13855 non-essential high NA high_confidence_nonessential NP_215997.1 91.0 0.03507 44.713 Exploratory ESM-2 calibrated P(essential)=0.141; HANSEN integrated essentiality score=0.139; ProteomeLM contextual percentile=0.035; target-priority score=44.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1057 ML2010 Q7AQ06 ML2010 Lipoprotein 153 0.02975 non-essential 0.13848 non-essential high agree high_confidence_nonessential Rv1906c 64.4 NE 0 0.85535 70.197 Strong candidate ESM-2 calibrated P(essential)=0.030; HANSEN integrated essentiality score=0.138; Mtb RBH anchor Rv1906c=non-essential (agree); ProteomeLM contextual percentile=0.855; target-priority score=70.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1058 ML2631 Q7APS7 ML2631 Possible oxidoreductase 449 0.05933 non-essential 0.1383 non-essential high NA high_confidence_nonessential NP_214675.1 78.8 0.36569 59.714 Moderate candidate ESM-2 calibrated P(essential)=0.059; HANSEN integrated essentiality score=0.138; ProteomeLM contextual percentile=0.366; target-priority score=59.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1059 ML1216 P45488 bioA ML1216 B1170_C2_195 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase (EC 2.6.1.62) (7,8-diamino-pelargonic acid aminotransferase) (DAPA AT) (DAPA aminotransferase) (7,8-diaminononanoate synthase) (DANS) (Diaminopelargonic acid synthase) 436 0.06981 non-essential 0.13803 non-essential high NA high_confidence_nonessential NP_216084.1 85.1 0.29054 68.372 Strong candidate ESM-2 calibrated P(essential)=0.070; HANSEN integrated essentiality score=0.138; ProteomeLM contextual percentile=0.291; target-priority score=68.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1060 ML1633 Q9CBT1 ML1633 Possible secreted hydrolase 535 0.03604 non-essential 0.1379 non-essential high NA high_confidence_nonessential NP_216740.1 84.8 0.46525 61.388 Moderate candidate ESM-2 calibrated P(essential)=0.036; HANSEN integrated essentiality score=0.138; ProteomeLM contextual percentile=0.465; target-priority score=61.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1061 ML0510 Q9CCT1 ML0510 AAA+ ATPase domain-containing protein 473 0.14234 non-essential 0.13766 non-essential high agree high_confidence_nonessential Rv2559c 84.2 NE 0 0.2511 54.293 Moderate candidate ESM-2 calibrated P(essential)=0.142; HANSEN integrated essentiality score=0.138; Mtb RBH anchor Rv2559c=non-essential (agree); ProteomeLM contextual percentile=0.251; target-priority score=54.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1062 ML1700 O33107 gatB ML1700 MLCB637.15 Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit B (Asp/Glu-ADT subunit B) (EC 6.3.5.-) 509 0.14132 non-essential 0.13766 non-essential high NA high_confidence_nonessential NP_217525.1 88.4 0.00814 52.089 Moderate candidate ESM-2 calibrated P(essential)=0.141; HANSEN integrated essentiality score=0.138; ProteomeLM contextual percentile=0.008; target-priority score=52.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1063 ML1402 Q9CC16 pheT ML1402 Phenylalanine--tRNA ligase beta subunit (EC 6.1.1.20) (Phenylalanyl-tRNA synthetase beta subunit) (PheRS) 835 0.12977 non-essential 0.13761 non-essential high NA high_confidence_nonessential NP_216166.1 78.9 0.05135 55.328 Moderate candidate ESM-2 calibrated P(essential)=0.130; HANSEN integrated essentiality score=0.138; ProteomeLM contextual percentile=0.051; target-priority score=55.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:45Z 1064 ML1079 Q9CCA4 tatB ML1079 Sec-independent protein translocase protein TatB 120 0.01544 non-essential 0.1376 non-essential high NA high_confidence_nonessential NP_215740.1 74.8 0.56418 59.298 Moderate candidate ESM-2 calibrated P(essential)=0.015; HANSEN integrated essentiality score=0.138; ProteomeLM contextual percentile=0.564; target-priority score=59.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1065 ML2207 Q7APX7 ML2207 Bacterial SCP orthologue domain-containing protein 131 0.05767 non-essential 0.13756 non-essential high agree high_confidence_nonessential Rv0807 73.4 NE 0 0.69443 67.021 Strong candidate ESM-2 calibrated P(essential)=0.058; HANSEN integrated essentiality score=0.138; Mtb RBH anchor Rv0807=non-essential (agree); ProteomeLM contextual percentile=0.694; target-priority score=67.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1066 ML0798 Q9CCI1 ML0798 Uncharacterized protein 592 0.08883 non-essential 0.13746 non-essential high agree high_confidence_nonessential Rv2787 76.5 NE 0 0.53162 62.002 Moderate candidate ESM-2 calibrated P(essential)=0.089; HANSEN integrated essentiality score=0.137; Mtb RBH anchor Rv2787=non-essential (agree); ProteomeLM contextual percentile=0.532; target-priority score=62.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1067 ML1306 Q9CC38 ML1306 Carboxylate--amine ligase 274 0.08658 non-essential 0.13725 non-essential high agree high_confidence_nonessential Rv2125 84.7 NE 0 0.54101 62.397 Moderate candidate ESM-2 calibrated P(essential)=0.087; HANSEN integrated essentiality score=0.137; Mtb RBH anchor Rv2125=non-essential (agree); ProteomeLM contextual percentile=0.541; target-priority score=62.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1068 ML2591 Q9CD12 mce1C ML2591 Secreted protein 519 0.02795 non-essential 0.13723 non-essential high NA high_confidence_nonessential NP_214685.1 69.9 0.50845 57.979 Moderate candidate ESM-2 calibrated P(essential)=0.028; HANSEN integrated essentiality score=0.137; ProteomeLM contextual percentile=0.508; target-priority score=58.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1069 ML2421 Q49808 hemC ML2421 B2168_C1_179 B2168_C3_262 Porphobilinogen deaminase (PBG) (EC 2.5.1.61) (Hydroxymethylbilane synthase) (HMBS) (Pre-uroporphyrinogen synthase) 315 0.09148 non-essential 0.1372 non-essential high NA high_confidence_nonessential NP_215024.1 87.3 0.20664 61.438 Moderate candidate ESM-2 calibrated P(essential)=0.091; HANSEN integrated essentiality score=0.137; ProteomeLM contextual percentile=0.207; target-priority score=61.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1070 ML0429 Q7AQJ3 ML0429 Oxidoreductase 268 0.06636 non-essential 0.13699 non-essential high NA high_confidence_nonessential NP_217025.1 88.8 0.33438 56.763 Moderate candidate ESM-2 calibrated P(essential)=0.066; HANSEN integrated essentiality score=0.137; ProteomeLM contextual percentile=0.334; target-priority score=56.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1071 ML1988 Q9CBG8 ML1988 Probable integral membrane protein 237 0.03424 non-essential 0.13699 non-essential high NA high_confidence_nonessential NP_214607.1 70.0 0.48341 56.207 Moderate candidate ESM-2 calibrated P(essential)=0.034; HANSEN integrated essentiality score=0.137; ProteomeLM contextual percentile=0.483; target-priority score=56.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1072 ML1448 Q9CC01 ML1448 RNA polymerase sigma factor 184 0.02975 non-essential 0.13698 non-essential high NA high_confidence_nonessential NP_216585.1 81.7 0.48716 61.907 Moderate candidate ESM-2 calibrated P(essential)=0.030; HANSEN integrated essentiality score=0.137; ProteomeLM contextual percentile=0.487; target-priority score=61.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1073 ML0776 Q9CCI9 ML0776 ML0776 protein 85 0.00543 non-essential 0.13697 non-essential high agree high_confidence_nonessential Rv3242c 78.1 GA 0 0.97433 72.564 Strong candidate ESM-2 calibrated P(essential)=0.005; HANSEN integrated essentiality score=0.137; Mtb RBH anchor Rv3242c=non-essential (agree); ProteomeLM contextual percentile=0.974; target-priority score=72.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1074 ML0854 Q9CCF8 pnp ML0854 Polyribonucleotide nucleotidyltransferase (EC 2.7.7.8) (Polynucleotide phosphorylase) (PNPase) 773 0.14132 non-essential 0.13674 non-essential high NA high_confidence_nonessential NP_217299.1 90.6 0.00188 52.379 Moderate candidate ESM-2 calibrated P(essential)=0.141; HANSEN integrated essentiality score=0.137; ProteomeLM contextual percentile=0.002; target-priority score=52.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1075 ML1155 P53524 nucS ML1155 B1549_C3_223 Endonuclease NucS (EC 3.1.-.-) 220 0.07126 non-essential 0.1367 non-essential high NA high_confidence_nonessential NP_215837.1 87.7 0.30495 58.551 Moderate candidate ESM-2 calibrated P(essential)=0.071; HANSEN integrated essentiality score=0.137; ProteomeLM contextual percentile=0.305; target-priority score=58.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1076 ML2209 Q50025 cpsY ML2209 MLCB5.32c Exopolysaccharide phosphotransferase CpsY (EC 2.7.-.-) (Stealth protein CpsY) 542 0.03769 non-essential 0.13669 non-essential high NA high_confidence_nonessential NP_215321.1 82.3 0.44271 64.063 Moderate candidate ESM-2 calibrated P(essential)=0.038; HANSEN integrated essentiality score=0.137; ProteomeLM contextual percentile=0.443; target-priority score=64.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1077 ML0996 P46814 dapF ML0996 B2235_C3_233 Diaminopimelate epimerase (DAP epimerase) (EC 5.1.1.7) (PLP-independent amino acid racemase) 296 0.04552 non-essential 0.13661 non-essential high NA high_confidence_nonessential NP_217242.1 76.0 0.38698 70.62 Strong candidate ESM-2 calibrated P(essential)=0.046; HANSEN integrated essentiality score=0.137; ProteomeLM contextual percentile=0.387; target-priority score=70.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1078 ML2167 Q9CBD6 kdc ML2167 Alpha-keto-acid decarboxylase (KDC) (EC 4.1.1.-) 569 0.0533 non-essential 0.13648 non-essential high NA high_confidence_nonessential NP_215368.1 77.8 0.36882 64.414 Moderate candidate ESM-2 calibrated P(essential)=0.053; HANSEN integrated essentiality score=0.136; ProteomeLM contextual percentile=0.369; target-priority score=64.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1079 ML1471 Q9CBY8 folC ML1471 Dihydrofolate synthase/folylpolyglutamate synthase (EC 6.3.2.12) (EC 6.3.2.17) (Tetrahydrofolylpolyglutamate synthase) 485 0.10418 non-essential 0.13624 non-essential high NA high_confidence_nonessential NP_216963.1 78.7 0.14339 61.204 Moderate candidate ESM-2 calibrated P(essential)=0.104; HANSEN integrated essentiality score=0.136; ProteomeLM contextual percentile=0.143; target-priority score=61.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1080 ML0061 Q9CDD5 gltB ML0061 Ferredoxin-dependent glutamate synthase (EC 1.4.1.13) 1527 0.13165 non-essential 0.13607 non-essential high NA high_confidence_nonessential NP_218376.1 90.2 0.0407 52.935 Moderate candidate ESM-2 calibrated P(essential)=0.132; HANSEN integrated essentiality score=0.136; ProteomeLM contextual percentile=0.041; target-priority score=52.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:45Z 1081 ML0458 Q9CCT9 ML0458 Oxidoreductase 301 0.02975 non-essential 0.136 non-essential high NA high_confidence_nonessential 0.47965 62.508 Moderate candidate ESM-2 calibrated P(essential)=0.030; HANSEN integrated essentiality score=0.136; ProteomeLM contextual percentile=0.480; target-priority score=62.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1082 ML0833 Q9CCG2 dnaG ML0833 DNA primase (EC 2.7.7.101) 642 0.13829 non-essential 0.13597 non-essential high NA high_confidence_nonessential NP_216859.1 80.1 0.0025 55.365 Moderate candidate ESM-2 calibrated P(essential)=0.138; HANSEN integrated essentiality score=0.136; ProteomeLM contextual percentile=0.003; target-priority score=55.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1083 ML1253 Q9CC59 glbO ML1253 Group 2 truncated hemoglobin GlbO (Hemoglobin-like protein HbO) (Truncated hemoglobin) (TrHbO) 128 0.06185 non-essential 0.13565 non-essential high NA high_confidence_nonessential NP_216986.1 88.1 0.33751 60.06 Moderate candidate ESM-2 calibrated P(essential)=0.062; HANSEN integrated essentiality score=0.136; ProteomeLM contextual percentile=0.338; target-priority score=60.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1084 ML1547 Q7AQ45 ML1547 4'-phosphopantetheinyl transferase 227 0.02975 non-essential 0.13563 non-essential high NA high_confidence_nonessential NP_217310.1 79.7 0.47088 64.761 Moderate candidate ESM-2 calibrated P(essential)=0.030; HANSEN integrated essentiality score=0.136; ProteomeLM contextual percentile=0.471; target-priority score=64.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1085 ML1513 Q9CBW4 dapA ML1513 4-hydroxy-tetrahydrodipicolinate synthase (HTPA synthase) (EC 4.3.3.7) 300 0.05162 non-essential 0.13555 non-essential high NA high_confidence_nonessential NP_217269.1 87.0 0.35504 69.857 Strong candidate ESM-2 calibrated P(essential)=0.052; HANSEN integrated essentiality score=0.136; ProteomeLM contextual percentile=0.355; target-priority score=69.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1086 ML2472 Q9CB34 ML2472 Possible prephenate dehydrogenase 327 0.03424 non-essential 0.13554 non-essential high NA high_confidence_nonessential NP_218271.3 80.0 0.45585 62.684 Moderate candidate ESM-2 calibrated P(essential)=0.034; HANSEN integrated essentiality score=0.136; ProteomeLM contextual percentile=0.456; target-priority score=62.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1087 ML0663 Q7AQG6 ML0663 Uncharacterized protein 104 0.05295 non-essential 0.13544 non-essential high agree high_confidence_nonessential Rv3136A 69.3 NE 0 0.70758 65.817 Strong candidate ESM-2 calibrated P(essential)=0.053; HANSEN integrated essentiality score=0.135; Mtb RBH anchor Rv3136A=non-essential (agree); ProteomeLM contextual percentile=0.708; target-priority score=65.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1088 ML1964 Q9CBH7 rmlB ML1964 dTDP-glucose 4,6-dehydratase (EC 4.2.1.46) 333 0.10695 non-essential 0.1354 non-essential high NA high_confidence_nonessential NP_217981.1 84.2 0.13713 57.328 Moderate candidate ESM-2 calibrated P(essential)=0.107; HANSEN integrated essentiality score=0.135; ProteomeLM contextual percentile=0.137; target-priority score=57.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1089 ML1441 Q7AQ49 lnt ML1441 Apolipoprotein N-acyltransferase (ALP N-acyltransferase) (EC 2.3.1.269) 644 0.06278 non-essential 0.13532 non-essential high NA high_confidence_nonessential NP_216567.1 73.8 0.31872 64.343 Moderate candidate ESM-2 calibrated P(essential)=0.063; HANSEN integrated essentiality score=0.135; ProteomeLM contextual percentile=0.319; target-priority score=64.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1090 ML1607 O33024 ML1607 MLCB250.49 UPF0102 protein ML1607 96 0.00543 non-essential 0.13531 non-essential high agree high_confidence_nonessential Rv2898c 58.3 NE 0 0.95617 72.881 Strong candidate ESM-2 calibrated P(essential)=0.005; HANSEN integrated essentiality score=0.135; Mtb RBH anchor Rv2898c=non-essential (agree); ProteomeLM contextual percentile=0.956; target-priority score=72.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1091 ML0735 P46701 purK ML0735 B1308_F1_32 N5-carboxyaminoimidazole ribonucleotide synthase (N5-CAIR synthase) (EC 6.3.4.18) (5-(carboxyamino)imidazole ribonucleotide synthetase) 439 0.06636 non-essential 0.13508 non-essential high NA high_confidence_nonessential NP_217793.1 77.6 0.29305 66.998 Strong candidate ESM-2 calibrated P(essential)=0.066; HANSEN integrated essentiality score=0.135; ProteomeLM contextual percentile=0.293; target-priority score=67.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1092 ML1222 Q49626 ML1222 B1170_C3_229 Uncharacterized protein ML1222 198 0.00543 non-essential 0.13499 non-essential high NA high_confidence_nonessential NP_216107.1 66.3 0.58172 63.725 Moderate candidate ESM-2 calibrated P(essential)=0.005; HANSEN integrated essentiality score=0.135; ProteomeLM contextual percentile=0.582; target-priority score=63.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1093 ML0587 Q7AQI1 ML0587 Membrane protein 311 0.06901 non-essential 0.13479 non-essential high NA high_confidence_nonessential NP_215972.1 84.4 0.30119 59.524 Moderate candidate ESM-2 calibrated P(essential)=0.069; HANSEN integrated essentiality score=0.135; ProteomeLM contextual percentile=0.301; target-priority score=59.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1094 ML1945 Q7AQ15 ML1945 Secreted protein 257 0.03135 non-essential 0.13479 non-essential high agree high_confidence_nonessential Rv1100 63.4 NE 0 0.8159 68.785 Strong candidate ESM-2 calibrated P(essential)=0.031; HANSEN integrated essentiality score=0.135; Mtb RBH anchor Rv1100=non-essential (agree); ProteomeLM contextual percentile=0.816; target-priority score=68.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1095 ML1129 P46806 hom ML1129 Homoserine dehydrogenase (HDH) (HSD) (EC 1.1.1.3) 441 0.12098 non-essential 0.1345 non-essential high NA high_confidence_nonessential NP_215810.1 89.1 0.06011 59.823 Moderate candidate ESM-2 calibrated P(essential)=0.121; HANSEN integrated essentiality score=0.134; ProteomeLM contextual percentile=0.060; target-priority score=59.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1096 ML2349 Q49939 papA5 ML2349 MLCB2407.01 Phthiocerol/phthiodiolone dimycocerosyl transferase (EC 2.3.1.282) (Acyltransferase PapA5) (Phthiocerol/phthiodiolone O-acyltransferase) (Polyketide synthase-associated protein A5) 423 0.03949 non-essential 0.13446 non-essential high NA high_confidence_nonessential NP_217455.1 84.0 0.4114 67.438 Strong candidate ESM-2 calibrated P(essential)=0.039; HANSEN integrated essentiality score=0.134; ProteomeLM contextual percentile=0.411; target-priority score=67.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1097 ML0532 Q9CCR5 pyrB ML0532 Aspartate carbamoyltransferase catalytic subunit (EC 2.1.3.2) (Aspartate transcarbamylase) (ATCase) 321 0.09455 non-essential 0.13436 non-essential high NA high_confidence_nonessential NP_215896.1 89.4 0.1722 62.683 Moderate candidate ESM-2 calibrated P(essential)=0.095; HANSEN integrated essentiality score=0.134; ProteomeLM contextual percentile=0.172; target-priority score=62.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1098 ML2447 Q9CB48 murB ML2447 UDP-N-acetylenolpyruvoylglucosamine reductase (EC 1.3.1.98) (UDP-N-acetylmuramate dehydrogenase) 367 0.04656 non-essential 0.13429 non-essential high NA high_confidence_nonessential NP_214996.1 79.0 0.3588 73.966 Strong candidate ESM-2 calibrated P(essential)=0.047; HANSEN integrated essentiality score=0.134; ProteomeLM contextual percentile=0.359; target-priority score=74.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1099 ML1028 Q49992 dut ML1028 Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase) (EC 3.6.1.23) (dUTP pyrophosphatase) 154 0.01648 non-essential 0.13392 non-essential high NA high_confidence_nonessential NP_217213.1 90.9 0.49656 73.296 Strong candidate ESM-2 calibrated P(essential)=0.016; HANSEN integrated essentiality score=0.134; ProteomeLM contextual percentile=0.497; target-priority score=73.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1100 ML1055 Q49945 ML1055 u1756c; ML1181 MLCB1701.07c Putative ESAT-6-like protein Y 100 0.0 non-essential 0.13389 non-essential high NA high_confidence_nonessential NP_215713.1 58.3 0.60614 61.692 Moderate candidate ESM-2 calibrated P(essential)=0.000; HANSEN integrated essentiality score=0.134; ProteomeLM contextual percentile=0.606; target-priority score=61.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1101 ML0256 Q9CD41 ML0256 Membrane protein 227 0.07447 non-essential 0.13387 non-essential high NA high_confidence_nonessential NP_215540.1 71.2 0.30432 48.104 Exploratory ESM-2 calibrated P(essential)=0.074; HANSEN integrated essentiality score=0.134; ProteomeLM contextual percentile=0.304; target-priority score=48.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1102 ML2703 P46843 trxB/A trx ML2703 Bifunctional thioredoxin reductase/thioredoxin [Includes: Thioredoxin reductase (TRXR) (EC 1.8.1.9); Thioredoxin] 458 0.07935 non-essential 0.13378 non-essential high NA high_confidence_nonessential NP_218430.1 83.2 0.24045 62.034 Moderate candidate ESM-2 calibrated P(essential)=0.079; HANSEN integrated essentiality score=0.134; ProteomeLM contextual percentile=0.240; target-priority score=62.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1103 ML1680 O33128 fbiD ML1680 MLCB637.37c Phosphoenolpyruvate guanylyltransferase (PEP guanylyltransferase) (EC 2.7.7.105) 216 0.00543 non-essential 0.13364 non-essential high NA high_confidence_nonessential NP_217499.1 79.1 0.53538 76.779 Strong candidate ESM-2 calibrated P(essential)=0.005; HANSEN integrated essentiality score=0.134; ProteomeLM contextual percentile=0.535; target-priority score=76.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1104 ML2419 P46723 hemB ML2419 B2168_C3_264 Delta-aminolevulinic acid dehydratase (ALAD) (ALADH) (EC 4.2.1.24) (Porphobilinogen synthase) 329 0.10115 non-essential 0.13363 non-essential high NA high_confidence_nonessential NP_215026.1 87.8 0.13964 61.993 Moderate candidate ESM-2 calibrated P(essential)=0.101; HANSEN integrated essentiality score=0.134; ProteomeLM contextual percentile=0.140; target-priority score=62.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1105 ML2395 P41484 ag36 pra ML2395 Proline-rich antigen (Pra) (36 kDa antigen) 249 0.01172 non-essential 0.13362 non-essential high agree high_confidence_nonessential Rv1078 66.7 NE 0 0.90106 72.974 Strong candidate ESM-2 calibrated P(essential)=0.012; HANSEN integrated essentiality score=0.134; Mtb RBH anchor Rv1078=non-essential (agree); ProteomeLM contextual percentile=0.901; target-priority score=73.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1106 ML1558 Q9Z5J1 nusA ML1558 MLCB596.12 Transcription termination/antitermination protein NusA 347 0.14132 non-essential 0.13351 non-essential high NA high_confidence_nonessential NP_217357.1 91.9 0.00564 44.655 Exploratory ESM-2 calibrated P(essential)=0.141; HANSEN integrated essentiality score=0.134; ProteomeLM contextual percentile=0.006; target-priority score=44.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1107 ML0182 Q7AQM8 galU ML0182 UTP--glucose-1-phosphate uridylyltransferase (EC 2.7.7.9) 306 0.10695 non-essential 0.13351 non-essential high NA high_confidence_nonessential NP_215508.1 89.7 0.13024 55.893 Moderate candidate ESM-2 calibrated P(essential)=0.107; HANSEN integrated essentiality score=0.134; ProteomeLM contextual percentile=0.130; target-priority score=55.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1108 ML2259 Q9CBB7 ML2259 Possible membrane protein 96 0.05933 non-essential 0.13346 non-essential high NA high_confidence_nonessential NP_215058.1 65.6 0.36255 51.091 Moderate candidate ESM-2 calibrated P(essential)=0.059; HANSEN integrated essentiality score=0.133; ProteomeLM contextual percentile=0.363; target-priority score=51.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1109 ML1929 Q9CBI2 def ML1929 Peptide deformylase (PDF) (EC 3.5.1.88) (Polypeptide deformylase) 197 0.03949 non-essential 0.13346 non-essential high NA high_confidence_nonessential NP_214943.1 83.7 0.40075 69.059 Strong candidate ESM-2 calibrated P(essential)=0.039; HANSEN integrated essentiality score=0.133; ProteomeLM contextual percentile=0.401; target-priority score=69.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1110 ML0187 Q9CD64 ML0187 Acetyltransferase 353 0.04552 non-essential 0.13339 non-essential high NA high_confidence_nonessential NP_215513.1 69.7 0.3995 59.94 Moderate candidate ESM-2 calibrated P(essential)=0.046; HANSEN integrated essentiality score=0.133; ProteomeLM contextual percentile=0.399; target-priority score=59.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1111 ML2621 Q9CD00 ML2621 NYN domain-containing protein 195 0.02105 non-essential 0.13338 non-essential high agree high_confidence_nonessential Rv0207c 60.4 NE 0 0.85222 71.045 Strong candidate ESM-2 calibrated P(essential)=0.021; HANSEN integrated essentiality score=0.133; Mtb RBH anchor Rv0207c=non-essential (agree); ProteomeLM contextual percentile=0.852; target-priority score=71.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1112 ML2155 Q9CBE2 ML2155 Hypothetical 10.1 kDa protein 74 0.01019 non-essential 0.13336 non-essential high agree high_confidence_nonessential Rv0863 78.8 NE 0 0.92611 69.27 Strong candidate ESM-2 calibrated P(essential)=0.010; HANSEN integrated essentiality score=0.133; Mtb RBH anchor Rv0863=non-essential (agree); ProteomeLM contextual percentile=0.926; target-priority score=69.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1113 ML1157 Q7AQ90 ML1157 VOC domain-containing protein 155 0.03604 non-essential 0.13323 non-essential high agree high_confidence_nonessential Rv1322A 75.3 NE 0 0.76205 70.806 Strong candidate ESM-2 calibrated P(essential)=0.036; HANSEN integrated essentiality score=0.133; Mtb RBH anchor Rv1322A=non-essential (agree); ProteomeLM contextual percentile=0.762; target-priority score=70.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1114 ML1213 Q9CC68 ML1213 Conserved membrane protein 733 0.04011 non-essential 0.13305 non-essential high agree high_confidence_nonessential Rv1565c 76.5 NE 0 0.73575 70.821 Strong candidate ESM-2 calibrated P(essential)=0.040; HANSEN integrated essentiality score=0.133; Mtb RBH anchor Rv1565c=non-essential (agree); ProteomeLM contextual percentile=0.736; target-priority score=70.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1115 ML0537 Q9CCR1 pyrF ML0537 Orotidine 5'-phosphate decarboxylase (EC 4.1.1.23) (OMP decarboxylase) (OMPDCase) (OMPdecase) 282 0.02338 non-essential 0.13302 non-essential high NA high_confidence_nonessential NP_215901.1 77.3 0.46024 73.101 Strong candidate ESM-2 calibrated P(essential)=0.023; HANSEN integrated essentiality score=0.133; ProteomeLM contextual percentile=0.460; target-priority score=73.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1116 ML1006 Q9CCB8 ML1006 Peroxynitrite isomerase (EC 5.99.-.-) (Ferric nitrobindin) (Nb(III)) 161 0.03949 non-essential 0.133 non-essential high agree high_confidence_nonessential Rv2717c 74.2 NE 0 0.68691 81.236 High-priority ESM-2 calibrated P(essential)=0.039; HANSEN integrated essentiality score=0.133; Mtb RBH anchor Rv2717c=non-essential (agree); ProteomeLM contextual percentile=0.687; target-priority score=81.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1117 ML1099 Q9CC94 lprE ML1099 Putative lipoprotein LprE 202 0.00543 non-essential 0.13295 non-essential high NA high_confidence_nonessential NP_215768.1 64.0 0.57545 61.775 Moderate candidate ESM-2 calibrated P(essential)=0.005; HANSEN integrated essentiality score=0.133; ProteomeLM contextual percentile=0.575; target-priority score=61.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1118 ML1027 Q7AQA8 ML1027 Possible membrane protein 157 0.04821 non-essential 0.13286 non-essential high NA high_confidence_nonessential NP_217214.1 79.5 0.39574 55.963 Moderate candidate ESM-2 calibrated P(essential)=0.048; HANSEN integrated essentiality score=0.133; ProteomeLM contextual percentile=0.396; target-priority score=56.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1119 ML1514 Q9CBW3 thyX ML1514 Flavin-dependent thymidylate synthase (FDTS) (EC 2.1.1.148) (FAD-dependent thymidylate synthase) (Thymidylate synthase ThyX) (TS) (TSase) 254 0.0518 non-essential 0.13276 non-essential high NA high_confidence_nonessential NP_217270.1 81.9 0.33626 70.395 Strong candidate ESM-2 calibrated P(essential)=0.052; HANSEN integrated essentiality score=0.133; ProteomeLM contextual percentile=0.336; target-priority score=70.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1120 ML1494 Q9CBX5 ML1494 Conserved membrane protein 117 0.01412 non-essential 0.13256 non-essential high agree high_confidence_nonessential Rv1171 62.5 NE 0 0.88353 71.471 Strong candidate ESM-2 calibrated P(essential)=0.014; HANSEN integrated essentiality score=0.133; Mtb RBH anchor Rv1171=non-essential (agree); ProteomeLM contextual percentile=0.884; target-priority score=71.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1121 ML0431 Q9CCU3 ML0431 Membrane protein 259 0.02734 non-essential 0.13241 non-essential high agree high_confidence_nonessential Rv2507 63.3 NE 0 0.81716 68.582 Strong candidate ESM-2 calibrated P(essential)=0.027; HANSEN integrated essentiality score=0.132; Mtb RBH anchor Rv2507=non-essential (agree); ProteomeLM contextual percentile=0.817; target-priority score=68.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1122 ML1173 P50474 ML1173 B1549_C2_211 Uncharacterized protein ML1173 284 0.01761 non-essential 0.13211 non-essential high agree high_confidence_nonessential Rv1339 87.3 NE 0 0.84346 74.399 Strong candidate ESM-2 calibrated P(essential)=0.018; HANSEN integrated essentiality score=0.132; Mtb RBH anchor Rv1339=non-essential (agree); ProteomeLM contextual percentile=0.843; target-priority score=74.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1123 ML1658 O69470 mutM fpg ML1658 MLCB1243.16 Formamidopyrimidine-DNA glycosylase (Fapy-DNA glycosylase) (EC 3.2.2.23) (DNA-(apurinic or apyrimidinic site) lyase MutM) (AP lyase MutM) (EC 4.2.99.18) 282 0.09638 non-essential 0.13189 non-essential high NA high_confidence_nonessential NP_217440.1 80.6 0.15905 59.353 Moderate candidate ESM-2 calibrated P(essential)=0.096; HANSEN integrated essentiality score=0.132; ProteomeLM contextual percentile=0.159; target-priority score=59.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1124 ML2401 Q7APV2 ML2401 3-hydroxyisobutyryl-CoA hydrolase (EC 3.1.2.4) 345 0.05813 non-essential 0.13184 non-essential high NA high_confidence_nonessential NP_215587.1 78.0 0.32311 63.142 Moderate candidate ESM-2 calibrated P(essential)=0.058; HANSEN integrated essentiality score=0.132; ProteomeLM contextual percentile=0.323; target-priority score=63.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1125 ML1752 Q9CBP4 ML1752 EAL domain-containing protein 302 0.03424 non-essential 0.1318 non-essential high agree high_confidence_nonessential Rv1357c 73.9 NE 0 0.76393 69.721 Strong candidate ESM-2 calibrated P(essential)=0.034; HANSEN integrated essentiality score=0.132; Mtb RBH anchor Rv1357c=non-essential (agree); ProteomeLM contextual percentile=0.764; target-priority score=69.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1126 ML2055 P46842 apa modD ML2055 MLCB1788.01c Alanine and proline-rich secreted protein Apa (Antigen 43L) (FAP-L) (Fibronectin attachment protein) 287 0.06716 non-essential 0.13176 non-essential high agree high_confidence_nonessential Rv1860 77.2 NE 0 0.60175 62.576 Moderate candidate ESM-2 calibrated P(essential)=0.067; HANSEN integrated essentiality score=0.132; Mtb RBH anchor Rv1860=non-essential (agree); ProteomeLM contextual percentile=0.602; target-priority score=62.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1127 ML0201 Q7AQM3 ML0201 Membrane protein 530 0.02338 non-essential 0.13162 non-essential high NA high_confidence_nonessential NP_218162.1 85.5 0.49029 60.071 Moderate candidate ESM-2 calibrated P(essential)=0.023; HANSEN integrated essentiality score=0.132; ProteomeLM contextual percentile=0.490; target-priority score=60.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1128 ML2301 Q9CB92 nth ML2301 Endonuclease III (EC 4.2.99.18) (DNA-(apurinic or apyrimidinic site) lyase) 245 0.06981 non-essential 0.13146 non-essential high NA high_confidence_nonessential NP_218191.2 89.3 0.26738 63.104 Moderate candidate ESM-2 calibrated P(essential)=0.070; HANSEN integrated essentiality score=0.131; ProteomeLM contextual percentile=0.267; target-priority score=63.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1129 ML1660 O69468 ML1660 MLCB1243.14 Uncharacterized protein ML1660 217 0.02734 non-essential 0.1314 non-essential high agree high_confidence_nonessential Rv2926c 67.2 NE 0 0.80651 68.694 Strong candidate ESM-2 calibrated P(essential)=0.027; HANSEN integrated essentiality score=0.131; Mtb RBH anchor Rv2926c=non-essential (agree); ProteomeLM contextual percentile=0.807; target-priority score=68.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1130 ML2144 Q7APY3 ML2144 Possible exported protein 162 0.0533 non-essential 0.13124 non-essential high agree high_confidence_nonessential Rv0875c 71.6 NE 0 0.6675 65.027 Strong candidate ESM-2 calibrated P(essential)=0.053; HANSEN integrated essentiality score=0.131; Mtb RBH anchor Rv0875c=non-essential (agree); ProteomeLM contextual percentile=0.668; target-priority score=65.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1131 ML2028 P31951 fbpB ML2028 MLCB561.03c Diacylglycerol acyltransferase/mycolyltransferase Ag85B (DGAT) (EC 2.3.1.122) (EC 2.3.1.20) (30 kDa extracellular protein) (Acyl-CoA:diacylglycerol acyltransferase) (Antigen 85 complex B) (85B) (Ag85B) (Extracellular alpha-antigen) (Fibronectin-binding protein B) (Fbps B) 327 0.04656 non-essential 0.13116 non-essential high NA high_confidence_nonessential NP_216402.1 83.0 0.36318 66.209 Strong candidate ESM-2 calibrated P(essential)=0.047; HANSEN integrated essentiality score=0.131; ProteomeLM contextual percentile=0.363; target-priority score=66.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1132 ML1649 Q7AQ35 ML1649 DUF3052 domain-containing protein 140 0.04041 non-essential 0.13114 non-essential high agree high_confidence_nonessential Rv2239c 85.7 NE 0 0.72887 68.002 Strong candidate ESM-2 calibrated P(essential)=0.040; HANSEN integrated essentiality score=0.131; Mtb RBH anchor Rv2239c=non-essential (agree); ProteomeLM contextual percentile=0.729; target-priority score=68.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1133 ML0468 Q49657 ML0468 Probable membrane transporter protein 260 0.00543 non-essential 0.13106 non-essential high NA high_confidence_nonessential 0.5598 63.322 Moderate candidate ESM-2 calibrated P(essential)=0.005; HANSEN integrated essentiality score=0.131; ProteomeLM contextual percentile=0.560; target-priority score=63.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1134 ML2459 Q9CB40 umaA2 ML2459 Mycolic acid synthase 295 0.09148 non-essential 0.13103 non-essential high NA high_confidence_nonessential YP_177730.1 81.9 0.18723 55.695 Moderate candidate ESM-2 calibrated P(essential)=0.091; HANSEN integrated essentiality score=0.131; ProteomeLM contextual percentile=0.187; target-priority score=55.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1135 ML2269 Q9CBB1 ML2269 Hydrolase 265 0.03604 non-essential 0.13098 non-essential high NA high_confidence_nonessential NP_215068.1 83.9 0.4258 60.959 Moderate candidate ESM-2 calibrated P(essential)=0.036; HANSEN integrated essentiality score=0.131; ProteomeLM contextual percentile=0.426; target-priority score=61.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1136 ML0015 Q7AQP6 pabA ML0015 p-aminobenzoate synthase glutamine amidotransferase 232 0.0949 non-essential 0.13075 non-essential high NA high_confidence_nonessential YP_177615.1 79.7 0.18096 51.925 Moderate candidate ESM-2 calibrated P(essential)=0.095; HANSEN integrated essentiality score=0.131; ProteomeLM contextual percentile=0.181; target-priority score=51.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1137 ML1805 Q9CBM2 cpfC hemH hemZ ML1805 Coproporphyrin III ferrochelatase (EC 4.99.1.9) 336 0.04897 non-essential 0.1307 non-essential high NA high_confidence_nonessential NP_216001.1 76.8 0.34126 68.972 Strong candidate ESM-2 calibrated P(essential)=0.049; HANSEN integrated essentiality score=0.131; ProteomeLM contextual percentile=0.341; target-priority score=69.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1138 ML1691 O33117 leuB ML1691 MLCB637.26 3-isopropylmalate dehydrogenase (EC 1.1.1.85) (3-IPM-DH) (Beta-IPM dehydrogenase) (IMDH) 336 0.05936 non-essential 0.13056 non-essential high NA high_confidence_nonessential NP_217511.1 83.9 0.2943 68.46 Strong candidate ESM-2 calibrated P(essential)=0.059; HANSEN integrated essentiality score=0.131; ProteomeLM contextual percentile=0.294; target-priority score=68.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1139 ML2330 O69519 ML2330 MLCB2407.20 Nucleoid-associated protein ML2330 116 0.02975 non-essential 0.13053 non-essential high agree high_confidence_nonessential Rv3716c 85.6 NE 0 0.78021 69.324 Strong candidate ESM-2 calibrated P(essential)=0.030; HANSEN integrated essentiality score=0.131; Mtb RBH anchor Rv3716c=non-essential (agree); ProteomeLM contextual percentile=0.780; target-priority score=69.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1140 ML2304 Q9CB89 ML2304 Uncharacterized protein 174 0.01233 non-essential 0.13049 non-essential high agree high_confidence_nonessential Rv3678c 64.2 NE 0 0.86725 72.748 Strong candidate ESM-2 calibrated P(essential)=0.012; HANSEN integrated essentiality score=0.130; Mtb RBH anchor Rv3678c=non-essential (agree); ProteomeLM contextual percentile=0.867; target-priority score=72.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1141 ML1177 P54134 lprD ML1177 B1549_F3_106 MLCB1701.03c Putative lipoprotein LprD 126 0.01172 non-essential 0.13041 non-essential high NA high_confidence_nonessential NP_215859.1 79.2 0.53788 59.668 Moderate candidate ESM-2 calibrated P(essential)=0.012; HANSEN integrated essentiality score=0.130; ProteomeLM contextual percentile=0.538; target-priority score=59.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1142 ML2041 P52678 oxyR ML2041 Probable hydrogen peroxide-inducible genes activator 311 0.03924 non-essential 0.1304 non-essential high NA high_confidence_nonessential 0.41327 59.074 Moderate candidate ESM-2 calibrated P(essential)=0.039; HANSEN integrated essentiality score=0.130; ProteomeLM contextual percentile=0.413; target-priority score=59.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1143 ML2391 Q7APV3 mca ML2391 Mycothiol S-conjugate amidase (EC 3.5.1.115) 290 0.10015 non-essential 0.13032 non-essential high NA high_confidence_nonessential NP_215598.1 86.8 0.13463 58.63 Moderate candidate ESM-2 calibrated P(essential)=0.100; HANSEN integrated essentiality score=0.130; ProteomeLM contextual percentile=0.135; target-priority score=58.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1144 ML1174 P37939 rph rnpH rphA ML1174 B1549_C1_182 Ribonuclease PH (RNase PH) (EC 2.7.7.56) (tRNA nucleotidyltransferase) 259 0.08245 non-essential 0.13006 non-essential high NA high_confidence_nonessential NP_215856.1 89.2 0.20726 61.039 Moderate candidate ESM-2 calibrated P(essential)=0.082; HANSEN integrated essentiality score=0.130; ProteomeLM contextual percentile=0.207; target-priority score=61.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1145 ML2672 Q7APS3 icd2 ML2672 Isocitrate dehydrogenase [NADP] (EC 1.1.1.42) (Oxalosuccinate decarboxylase) 746 0.08082 non-essential 0.13002 non-essential high NA high_confidence_nonessential NP_214580.1 85.4 0.21165 62.013 Moderate candidate ESM-2 calibrated P(essential)=0.081; HANSEN integrated essentiality score=0.130; ProteomeLM contextual percentile=0.212; target-priority score=62.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1146 ML0089 Q9CDB9 ML0089 Hydrolase 281 0.08446 non-essential 0.13 non-essential high agree high_confidence_nonessential Rv3813c 80.4 NE 0 0.48028 62.589 Moderate candidate ESM-2 calibrated P(essential)=0.084; HANSEN integrated essentiality score=0.130; Mtb RBH anchor Rv3813c=non-essential (agree); ProteomeLM contextual percentile=0.480; target-priority score=62.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1147 ML0706 Q9CCL7 pmmB ML0706 Phospho-sugar mutase 538 0.03424 non-essential 0.12998 non-essential high NA high_confidence_nonessential NP_217825.1 74.7 0.4283 60.928 Moderate candidate ESM-2 calibrated P(essential)=0.034; HANSEN integrated essentiality score=0.130; ProteomeLM contextual percentile=0.428; target-priority score=60.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1148 ML2697 Q9CCY1 pcnA ML2697 PcnA 486 0.13631 non-essential 0.12989 non-essential high NA high_confidence_nonessential YP_178026.1 83.9 0.00501 45.44 Exploratory ESM-2 calibrated P(essential)=0.136; HANSEN integrated essentiality score=0.130; ProteomeLM contextual percentile=0.005; target-priority score=45.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1149 ML0814 Q9CCH1 ML0814 ATP-binding protein 82 0.03604 non-essential 0.12984 non-essential high agree high_confidence_nonessential Rv3208A 82.3 NE 0 0.75016 66.407 Strong candidate ESM-2 calibrated P(essential)=0.036; HANSEN integrated essentiality score=0.130; Mtb RBH anchor Rv3208A=non-essential (agree); ProteomeLM contextual percentile=0.750; target-priority score=66.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1150 ML0781 Q9CCI6 ML0781 RCK C-terminal domain-containing protein 160 0.05767 non-essential 0.12983 non-essential high agree high_confidence_nonessential Rv3237c 80.6 NE 0 0.6293 64.592 Moderate candidate ESM-2 calibrated P(essential)=0.058; HANSEN integrated essentiality score=0.130; Mtb RBH anchor Rv3237c=non-essential (agree); ProteomeLM contextual percentile=0.629; target-priority score=64.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1151 ML0550 Q9CCQ2 ML0550 MarR-family transcriptional regulator 161 0.07138 non-essential 0.1298 non-essential high NA high_confidence_nonessential NP_215920.1 79.1 0.2774 53.92 Moderate candidate ESM-2 calibrated P(essential)=0.071; HANSEN integrated essentiality score=0.130; ProteomeLM contextual percentile=0.277; target-priority score=53.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1152 ML2605 Q7APT5 ML2605 TIGR04338 family metallohydrolase 168 0.05457 non-essential 0.1298 non-essential high agree high_confidence_nonessential Rv0185 76.4 NE 0 0.63932 66.242 Strong candidate ESM-2 calibrated P(essential)=0.055; HANSEN integrated essentiality score=0.130; Mtb RBH anchor Rv0185=non-essential (agree); ProteomeLM contextual percentile=0.639; target-priority score=66.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1153 ML2501 Q9CB20 ML2501 Probable iron-sulphur-binding reductase 880 0.1041 non-essential 0.12979 non-essential high NA high_confidence_nonessential NP_214852.1 78.2 0.14214 48.863 Exploratory ESM-2 calibrated P(essential)=0.104; HANSEN integrated essentiality score=0.130; ProteomeLM contextual percentile=0.142; target-priority score=48.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:45Z 1154 ML0286 O69600 fba ML0286 MLCB4.29c Fructose-bisphosphate aldolase (FBP aldolase) (FBPA) (EC 4.1.2.13) (Fructose-1,6-bisphosphate aldolase) 345 0.12738 non-essential 0.12971 non-essential high NA high_confidence_nonessential NP_214877.1 87.7 0.00939 57.511 Moderate candidate ESM-2 calibrated P(essential)=0.127; HANSEN integrated essentiality score=0.130; ProteomeLM contextual percentile=0.009; target-priority score=57.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1155 ML1728 Q9CBQ5 ctaD ML1728 Probable cytochrome c oxidase subunit 1 (EC 7.1.1.9) (Cytochrome aa3 subunit 1) (Cytochrome c oxidase polypeptide I) 574 0.03029 non-essential 0.12971 non-essential high NA high_confidence_nonessential NP_217559.1 95.6 0.41202 72.074 Strong candidate ESM-2 calibrated P(essential)=0.030; HANSEN integrated essentiality score=0.130; ProteomeLM contextual percentile=0.412; target-priority score=72.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1156 ML2593 Q9CD10 lprK ML2593 Lipoprotein 392 0.02795 non-essential 0.1297 non-essential high NA high_confidence_nonessential NP_214687.1 76.3 0.469 56.332 Moderate candidate ESM-2 calibrated P(essential)=0.028; HANSEN integrated essentiality score=0.130; ProteomeLM contextual percentile=0.469; target-priority score=56.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1157 ML0235 P24428 clpC ML0235 Probable ATP-dependent Clp protease ATP-binding subunit 848 0.12139 non-essential 0.1296 non-essential high NA high_confidence_nonessential YP_177995.1 97.0 0.06575 47.469 Exploratory ESM-2 calibrated P(essential)=0.121; HANSEN integrated essentiality score=0.130; ProteomeLM contextual percentile=0.066; target-priority score=47.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:45Z 1158 ML0047 Q9CDD9 ML0047 Membrane protein 512 0.07973 non-essential 0.12957 non-essential high NA high_confidence_nonessential NP_218394.1 74.2 0.24671 50.876 Moderate candidate ESM-2 calibrated P(essential)=0.080; HANSEN integrated essentiality score=0.130; ProteomeLM contextual percentile=0.247; target-priority score=50.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1159 ML1255 Q9CC58 ML1255 DUF5130 domain-containing protein 163 0.08883 non-essential 0.12948 non-essential high agree high_confidence_nonessential Rv2468c 81.2 NE 0 0.47401 57.551 Moderate candidate ESM-2 calibrated P(essential)=0.089; HANSEN integrated essentiality score=0.129; Mtb RBH anchor Rv2468c=non-essential (agree); ProteomeLM contextual percentile=0.474; target-priority score=57.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1160 ML2351 Q49935 ML2351 Probable antibiotic resistance membrane protein 288 0.00543 non-essential 0.12942 non-essential high NA high_confidence_nonessential NP_217453.1 64.4 0.55166 62.814 Moderate candidate ESM-2 calibrated P(essential)=0.005; HANSEN integrated essentiality score=0.129; ProteomeLM contextual percentile=0.552; target-priority score=62.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1161 ML0515 Q9CCS7 aroE ML0515 Shikimate 5-dehydrogenase 278 0.03604 non-essential 0.12923 non-essential high NA high_confidence_nonessential NP_217068.1 81.5 0.40639 64.076 Moderate candidate ESM-2 calibrated P(essential)=0.036; HANSEN integrated essentiality score=0.129; ProteomeLM contextual percentile=0.406; target-priority score=64.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1162 ML1497 Q9CBX3 ML1497 Possible secreted protein 617 0.09148 non-essential 0.1292 non-essential high NA high_confidence_nonessential NP_215682.1 80.3 0.19224 50.325 Moderate candidate ESM-2 calibrated P(essential)=0.091; HANSEN integrated essentiality score=0.129; ProteomeLM contextual percentile=0.192; target-priority score=50.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1163 ML2522 Q9CD38 ML2522 Secreted protein 218 0.05162 non-essential 0.12916 non-essential high agree high_confidence_nonessential Rv0309 78.0 NE 0 0.61052 74.274 Strong candidate ESM-2 calibrated P(essential)=0.052; HANSEN integrated essentiality score=0.129; Mtb RBH anchor Rv0309=non-essential (agree); ProteomeLM contextual percentile=0.611; target-priority score=74.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1164 ML1791 Q9CBN1 ML1791 RNA-binding protein 147 0.03861 non-essential 0.12905 non-essential high agree high_confidence_nonessential Rv1976c 65.3 NE 0 0.72073 67.61 Strong candidate ESM-2 calibrated P(essential)=0.039; HANSEN integrated essentiality score=0.129; Mtb RBH anchor Rv1976c=non-essential (agree); ProteomeLM contextual percentile=0.721; target-priority score=67.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1165 ML0748 Q9CCL0 ML0748 Uncharacterized protein 92 0.03654 non-essential 0.12903 non-essential high agree high_confidence_nonessential Rv3269 73.6 NE 0 0.7489 64.42 Moderate candidate ESM-2 calibrated P(essential)=0.037; HANSEN integrated essentiality score=0.129; Mtb RBH anchor Rv3269=non-essential (agree); ProteomeLM contextual percentile=0.749; target-priority score=64.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1166 ML2228 Q7APX3 ML2228 Transmembrane protein 206 0.00543 non-essential 0.12879 non-essential high NA high_confidence_nonessential NP_215293.1 67.2 0.55479 60.478 Moderate candidate ESM-2 calibrated P(essential)=0.005; HANSEN integrated essentiality score=0.129; ProteomeLM contextual percentile=0.555; target-priority score=60.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1167 ML2498 Q9CB21 ML2498 Possible enoyl-CoA hydratase 219 0.06488 non-essential 0.12877 non-essential high NA high_confidence_nonessential 0.29368 56.465 Moderate candidate ESM-2 calibrated P(essential)=0.065; HANSEN integrated essentiality score=0.129; ProteomeLM contextual percentile=0.294; target-priority score=56.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1168 ML0676 Q9CCM4 ML0676 DUF732 domain-containing protein 158 0.00543 non-essential 0.12873 non-essential high agree high_confidence_nonessential Rv3354 56.0 GA 0 0.89606 71.742 Strong candidate ESM-2 calibrated P(essential)=0.005; HANSEN integrated essentiality score=0.129; Mtb RBH anchor Rv3354=non-essential (agree); ProteomeLM contextual percentile=0.896; target-priority score=71.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1169 ML0880 Q9CCE7 qcrA ML0880 Cytochrome bc1 complex Rieske iron-sulfur subunit (Cytochrome bc1 reductase complex subunit QcrA) (Rieske iron-sulfur protein) 394 0.10418 non-essential 0.12868 non-essential high NA high_confidence_nonessential NP_216711.1 80.9 0.13838 47.801 Exploratory ESM-2 calibrated P(essential)=0.104; HANSEN integrated essentiality score=0.129; ProteomeLM contextual percentile=0.138; target-priority score=47.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1170 ML2664 Q7APS5 ML2664 Possible secreted protein 251 0.01648 non-essential 0.12859 non-essential high NA high_confidence_nonessential NP_214630.1 76.0 0.47652 69.459 Strong candidate ESM-2 calibrated P(essential)=0.016; HANSEN integrated essentiality score=0.129; ProteomeLM contextual percentile=0.477; target-priority score=69.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1171 ML0138 Q9CD79 fadD28 ML0138 Acyl-CoA synthetase 579 0.09148 non-essential 0.12857 non-essential high NA high_confidence_nonessential NP_217457.1 81.9 0.18159 52.685 Moderate candidate ESM-2 calibrated P(essential)=0.091; HANSEN integrated essentiality score=0.129; ProteomeLM contextual percentile=0.182; target-priority score=52.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1172 ML1446 Q9CC02 ML1446 Pyridoxamine 5'-phosphate oxidase N-terminal domain-containing protein 128 0.04386 non-essential 0.12852 non-essential high agree high_confidence_nonessential Rv2061c 71.0 NE 0 0.67376 69.645 Strong candidate ESM-2 calibrated P(essential)=0.044; HANSEN integrated essentiality score=0.129; Mtb RBH anchor Rv2061c=non-essential (agree); ProteomeLM contextual percentile=0.674; target-priority score=69.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1173 ML0018 Q9CDE6 pbpA ML0018 Peptidoglycan D,D-transpeptidase PbpA (EC 3.4.16.4) (Penicillin-binding protein A) 492 0.09789 non-essential 0.12848 non-essential high NA high_confidence_nonessential NP_214530.1 85.7 0.12586 61.467 Moderate candidate ESM-2 calibrated P(essential)=0.098; HANSEN integrated essentiality score=0.128; ProteomeLM contextual percentile=0.126; target-priority score=61.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1174 ML0245 Q9CD48 rplY ctc ML0245 Large ribosomal subunit protein bL25 (50S ribosomal protein L25) (General stress protein CTC) 215 0.06636 non-essential 0.12839 non-essential high NA high_confidence_nonessential NP_215531.1 73.9 0.28741 55.539 Moderate candidate ESM-2 calibrated P(essential)=0.066; HANSEN integrated essentiality score=0.128; ProteomeLM contextual percentile=0.287; target-priority score=55.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1175 ML1296 Q9CC43 ML1296 Uncharacterized protein 111 0.02041 non-essential 0.12814 non-essential high agree high_confidence_nonessential Rv2137c 75.5 NE 0 0.81778 68.234 Strong candidate ESM-2 calibrated P(essential)=0.020; HANSEN integrated essentiality score=0.128; Mtb RBH anchor Rv2137c=non-essential (agree); ProteomeLM contextual percentile=0.818; target-priority score=68.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1176 ML1322 Q49780 prcB ML1322 Proteasome subunit beta (EC 3.4.25.1) (20S proteasome beta subunit) (Proteasome core protein PrcB) 291 0.07987 non-essential 0.12813 non-essential high NA high_confidence_nonessential NP_216626.1 80.8 0.19912 63.955 Moderate candidate ESM-2 calibrated P(essential)=0.080; HANSEN integrated essentiality score=0.128; ProteomeLM contextual percentile=0.199; target-priority score=64.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1177 ML0065 Q7AQN8 ML0065 FAD-containing monooxygenase EthA (Prodrug activator EtaA) 494 0.10418 non-essential 0.12811 non-essential high NA high_confidence_nonessential NP_218371.1 80.1 0.11897 53.247 Moderate candidate ESM-2 calibrated P(essential)=0.104; HANSEN integrated essentiality score=0.128; ProteomeLM contextual percentile=0.119; target-priority score=53.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1178 ML0559 Q9CCP4 ribA ribBA ML0559 Riboflavin biosynthesis protein RibBA [Includes: 3,4-dihydroxy-2-butanone 4-phosphate synthase (DHBP synthase) (EC 4.1.99.12); GTP cyclohydrolase-2 (EC 3.5.4.25) (GTP cyclohydrolase II)] 435 0.06116 non-essential 0.128 non-essential high NA high_confidence_nonessential NP_215931.1 93.4 0.27614 66.699 Strong candidate ESM-2 calibrated P(essential)=0.061; HANSEN integrated essentiality score=0.128; ProteomeLM contextual percentile=0.276; target-priority score=66.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1179 ML1525 Q9CBV8 ML1525 Flavodoxin 151 0.09148 non-essential 0.12765 non-essential high agree high_confidence_nonessential Rv2771c 53.4 NE 0 0.43519 58.478 Moderate candidate ESM-2 calibrated P(essential)=0.091; HANSEN integrated essentiality score=0.128; Mtb RBH anchor Rv2771c=non-essential (agree); ProteomeLM contextual percentile=0.435; target-priority score=58.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1180 ML2432 P54581 ML2432 B2168_C2_210 Uncharacterized protein ML2432 280 0.09832 non-essential 0.12752 non-essential high agree high_confidence_nonessential Rv0498 89.6 NE 0 0.40013 57.034 Moderate candidate ESM-2 calibrated P(essential)=0.098; HANSEN integrated essentiality score=0.128; Mtb RBH anchor Rv0498=non-essential (agree); ProteomeLM contextual percentile=0.400; target-priority score=57.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1181 ML1264 Q9X7C3 hisI ML1264 MLCB1610.27 Phosphoribosyl-AMP cyclohydrolase (PRA-CH) (EC 3.5.4.19) 115 0.0299 non-essential 0.12748 non-essential high NA high_confidence_nonessential NP_216638.2 84.3 0.40513 70.57 Strong candidate ESM-2 calibrated P(essential)=0.030; HANSEN integrated essentiality score=0.127; ProteomeLM contextual percentile=0.405; target-priority score=70.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1182 ML0387 Q49729 guaB ML0387 B1620_C3_238 Inosine-5'-monophosphate dehydrogenase (IMP dehydrogenase) (IMPD) (IMPDH) (EC 1.1.1.205) 529 0.08883 non-essential 0.12734 non-essential high NA high_confidence_nonessential NP_217928.1 92.4 0.15717 62.655 Moderate candidate ESM-2 calibrated P(essential)=0.089; HANSEN integrated essentiality score=0.127; ProteomeLM contextual percentile=0.157; target-priority score=62.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1183 ML2065 Q9CBE9 gnd ML2065 6-phosphogluconate dehydrogenase, decarboxylating (EC 1.1.1.44) 483 0.08554 non-essential 0.12733 non-essential high NA high_confidence_nonessential YP_177848.1 86.8 0.16844 63.946 Moderate candidate ESM-2 calibrated P(essential)=0.086; HANSEN integrated essentiality score=0.127; ProteomeLM contextual percentile=0.168; target-priority score=63.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1184 ML1800 Q9CBM6 mutA ML1800 Methylmalonyl-CoA mutase small subunit (EC 5.4.99.2) 636 0.04818 non-essential 0.12721 non-essential high NA high_confidence_nonessential NP_216008.1 75.2 0.3325 66.225 Strong candidate ESM-2 calibrated P(essential)=0.048; HANSEN integrated essentiality score=0.127; ProteomeLM contextual percentile=0.332; target-priority score=66.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1185 ML0150 Q9CD75 pgi ML0150 Glucose-6-phosphate isomerase (GPI) (EC 5.3.1.9) (Phosphoglucose isomerase) (PGI) (Phosphohexose isomerase) (PHI) 554 0.08711 non-essential 0.12715 non-essential high NA high_confidence_nonessential NP_215461.1 85.9 0.16281 63.055 Moderate candidate ESM-2 calibrated P(essential)=0.087; HANSEN integrated essentiality score=0.127; ProteomeLM contextual percentile=0.163; target-priority score=63.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1186 ML2495 Q9CB23 grpE ML2495 Protein GrpE (HSP-70 cofactor) 229 0.05422 non-essential 0.127 non-essential high NA high_confidence_nonessential NP_214865.1 76.0 0.33688 54.865 Moderate candidate ESM-2 calibrated P(essential)=0.054; HANSEN integrated essentiality score=0.127; ProteomeLM contextual percentile=0.337; target-priority score=54.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1187 ML1472 Q9CBY7 valS ML1472 Valine--tRNA ligase (EC 6.1.1.9) (Valyl-tRNA synthetase) (ValRS) 886 0.03424 non-essential 0.12693 non-essential high NA high_confidence_nonessential NP_216964.1 85.4 0.38885 68.229 Strong candidate ESM-2 calibrated P(essential)=0.034; HANSEN integrated essentiality score=0.127; ProteomeLM contextual percentile=0.389; target-priority score=68.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:45Z 1188 ML1346 Q9CC34 ML1346 Possible long-chain acyl-CoA synthase 1002 0.10115 non-essential 0.12681 non-essential high NA high_confidence_nonessential NP_216199.1 85.9 0.13901 48.568 Exploratory ESM-2 calibrated P(essential)=0.101; HANSEN integrated essentiality score=0.127; ProteomeLM contextual percentile=0.139; target-priority score=48.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:45Z 1189 ML0426 Q9CCU5 lppS ML0426 Secreted protein 404 0.04818 non-essential 0.12667 non-essential high NA high_confidence_nonessential NP_217034.1 82.4 0.33563 64.062 Moderate candidate ESM-2 calibrated P(essential)=0.048; HANSEN integrated essentiality score=0.127; ProteomeLM contextual percentile=0.336; target-priority score=64.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1190 ML0116 Q9CD98 ML0116 Membrane protein 654 0.05259 non-essential 0.12661 non-essential high NA high_confidence_nonessential NP_218296.1 65.5 0.34189 54.929 Moderate candidate ESM-2 calibrated P(essential)=0.053; HANSEN integrated essentiality score=0.127; ProteomeLM contextual percentile=0.342; target-priority score=54.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1191 ML2568 Q7APU1 ML2568 Possible TetR-family transcriptional regulator 208 0.04947 non-essential 0.12657 non-essential high NA high_confidence_nonessential NP_214752.1 80.9 0.35128 56.538 Moderate candidate ESM-2 calibrated P(essential)=0.049; HANSEN integrated essentiality score=0.127; ProteomeLM contextual percentile=0.351; target-priority score=56.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1192 ML2639 Q9CCZ5 ML2639 Aldehyde dehydrogenase 501 0.06636 non-essential 0.12646 non-essential high NA high_confidence_nonessential NP_214661.1 77.1 0.268 58.28 Moderate candidate ESM-2 calibrated P(essential)=0.066; HANSEN integrated essentiality score=0.126; ProteomeLM contextual percentile=0.268; target-priority score=58.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1193 ML0852 Q7AQE9 ribF ML0852 Riboflavin biosynthesis protein [Includes: Riboflavin kinase (EC 2.7.1.26) (Flavokinase); FMN adenylyltransferase (EC 2.7.7.2) (FAD pyrophosphorylase) (FAD synthase)] 331 0.06543 non-essential 0.12643 non-essential high NA high_confidence_nonessential NP_217302.1 87.5 0.25485 64.136 Moderate candidate ESM-2 calibrated P(essential)=0.065; HANSEN integrated essentiality score=0.126; ProteomeLM contextual percentile=0.255; target-priority score=64.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1194 ML0451 Q7AQJ1 ML0451 Nudix hydrolase domain-containing protein 349 0.01019 non-essential 0.12621 non-essential high NA high_confidence_nonessential NP_217125.1 77.7 0.51284 62.15 Moderate candidate ESM-2 calibrated P(essential)=0.010; HANSEN integrated essentiality score=0.126; ProteomeLM contextual percentile=0.513; target-priority score=62.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1195 ML1080 P53382 mrp ML1080 Iron-sulfur cluster carrier protein 383 0.12585 non-essential 0.12608 non-essential high NA high_confidence_nonessential NP_215745.1 82.1 0.0263 46.881 Exploratory ESM-2 calibrated P(essential)=0.126; HANSEN integrated essentiality score=0.126; ProteomeLM contextual percentile=0.026; target-priority score=46.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1196 ML0782 Q9CCI5 ML0782 Transmembrane transport protein 385 0.02795 non-essential 0.12602 non-essential high NA high_confidence_nonessential YP_177949.1 81.8 0.43957 58.988 Moderate candidate ESM-2 calibrated P(essential)=0.028; HANSEN integrated essentiality score=0.126; ProteomeLM contextual percentile=0.440; target-priority score=59.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1197 ML0456 O07151 thrS ML0456 MLCL581.18c Threonine--tRNA ligase (EC 6.1.1.3) (Threonyl-tRNA synthetase) (ThrRS) 702 0.07935 non-essential 0.12596 non-essential high NA high_confidence_nonessential NP_217130.1 84.0 0.19537 61.723 Moderate candidate ESM-2 calibrated P(essential)=0.079; HANSEN integrated essentiality score=0.126; ProteomeLM contextual percentile=0.195; target-priority score=61.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1198 ML2463 Q9CB38 ML2463 Acyl-ACP thioesterase 264 0.03604 non-essential 0.12569 non-essential high agree high_confidence_nonessential Rv0466 87.5 NE 0 0.69004 70.131 Strong candidate ESM-2 calibrated P(essential)=0.036; HANSEN integrated essentiality score=0.126; Mtb RBH anchor Rv0466=non-essential (agree); ProteomeLM contextual percentile=0.690; target-priority score=70.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1199 ML1036 P46838 ag45 ML1036 46 kDa membrane protein 429 0.08711 non-essential 0.12561 non-essential high NA high_confidence_nonessential NP_217200.1 74.3 0.19036 50.607 Moderate candidate ESM-2 calibrated P(essential)=0.087; HANSEN integrated essentiality score=0.126; ProteomeLM contextual percentile=0.190; target-priority score=50.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1200 ML0379 P37969 tsaD gcp ML0379 B1620_C3_226 B229_C3_246 u1620c u229e tRNA N6-adenosine threonylcarbamoyltransferase (EC 2.3.1.234) (N6-L-threonylcarbamoyladenine synthase) (t(6)A synthase) (t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaD) (tRNA threonylcarbamoyladenosine biosynthesis protein TsaD) 351 0.06543 non-essential 0.12551 non-essential high NA high_confidence_nonessential NP_217936.1 86.1 0.2536 62.71 Moderate candidate ESM-2 calibrated P(essential)=0.065; HANSEN integrated essentiality score=0.126; ProteomeLM contextual percentile=0.254; target-priority score=62.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1201 ML0813 Q9CCH2 ML0813 Membrane protein 195 0.01019 non-essential 0.12547 non-essential high agree high_confidence_nonessential Rv3209 57.3 NE 0 0.84033 70.641 Strong candidate ESM-2 calibrated P(essential)=0.010; HANSEN integrated essentiality score=0.125; Mtb RBH anchor Rv3209=non-essential (agree); ProteomeLM contextual percentile=0.840; target-priority score=70.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1202 ML1903 Q9CBK3 mmaA4 ML1903 Methyl mycolic acid synthase 4 298 0.09148 non-essential 0.12536 non-essential high NA high_confidence_nonessential NP_215156.1 87.8 0.1578 54.351 Moderate candidate ESM-2 calibrated P(essential)=0.091; HANSEN integrated essentiality score=0.125; ProteomeLM contextual percentile=0.158; target-priority score=54.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1203 ML0336 Q9CCW0 ML0336 ABC-tranporter ATP-binding protein 275 0.10695 non-essential 0.12515 non-essential high NA high_confidence_nonessential 0.10582 47.484 Exploratory ESM-2 calibrated P(essential)=0.107; HANSEN integrated essentiality score=0.125; ProteomeLM contextual percentile=0.106; target-priority score=47.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1204 ML0582 P55193 tal ML0582 B1496_F2_65/B1496_F1_27 MLCL536.39 Transaldolase (EC 2.2.1.2) 375 0.04041 non-essential 0.12479 non-essential high NA high_confidence_nonessential NP_215964.1 79.1 0.3444 69.435 Strong candidate ESM-2 calibrated P(essential)=0.040; HANSEN integrated essentiality score=0.125; ProteomeLM contextual percentile=0.344; target-priority score=69.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1205 ML1489 Q9CBX7 fdxA ML1489 Ferredoxin 108 0.09152 non-essential 0.12477 non-essential high NA high_confidence_nonessential NP_215693.1 91.5 0.16468 50.766 Moderate candidate ESM-2 calibrated P(essential)=0.092; HANSEN integrated essentiality score=0.125; ProteomeLM contextual percentile=0.165; target-priority score=50.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1206 ML0885 Q7AQE3 ML0885 Secreted protein 374 0.04818 non-essential 0.1247 non-essential high NA high_confidence_nonessential NP_216706.1 66.2 0.35066 55.02 Moderate candidate ESM-2 calibrated P(essential)=0.048; HANSEN integrated essentiality score=0.125; ProteomeLM contextual percentile=0.351; target-priority score=55.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1207 ML0081 Q9CDC2 ML0081 Membrane protein 450 0.02734 non-essential 0.12462 non-essential high agree high_confidence_nonessential Rv3835 74.3 NE 0 0.75141 66.155 Strong candidate ESM-2 calibrated P(essential)=0.027; HANSEN integrated essentiality score=0.125; Mtb RBH anchor Rv3835=non-essential (agree); ProteomeLM contextual percentile=0.751; target-priority score=66.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1208 ML0883 O69581 trpD ML0883 MLCB268.34c Anthranilate phosphoribosyltransferase (EC 2.4.2.18) 366 0.06759 non-essential 0.1246 non-essential high NA high_confidence_nonessential NP_216708.1 80.7 0.23168 64.985 Moderate candidate ESM-2 calibrated P(essential)=0.068; HANSEN integrated essentiality score=0.125; ProteomeLM contextual percentile=0.232; target-priority score=65.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1209 ML0868 O32953 cobT ML0868 MLCB22.08 Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase (NN:DBI PRT) (EC 2.4.2.21) (N(1)-alpha-phosphoribosyltransferase) 351 0.01648 non-essential 0.12458 non-essential high NA high_confidence_nonessential NP_216723.1 83.8 0.44333 72.724 Strong candidate ESM-2 calibrated P(essential)=0.016; HANSEN integrated essentiality score=0.125; ProteomeLM contextual percentile=0.443; target-priority score=72.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1210 ML0314 Q7AQJ7 ML0314 Esterase 335 0.07273 non-essential 0.12457 non-essential high NA high_confidence_nonessential NP_215592.1 79.7 0.23419 56.064 Moderate candidate ESM-2 calibrated P(essential)=0.073; HANSEN integrated essentiality score=0.125; ProteomeLM contextual percentile=0.234; target-priority score=56.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1211 ML2649 Q9CCZ2 ML2649 NodB homology domain-containing protein 271 0.09316 non-essential 0.12446 non-essential high NA high_confidence_nonessential 0.15592 50.569 Moderate candidate ESM-2 calibrated P(essential)=0.093; HANSEN integrated essentiality score=0.124; ProteomeLM contextual percentile=0.156; target-priority score=50.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1212 ML0558 Q9CCP5 ribC ML0558 Riboflavin synthase (EC 2.5.1.9) 207 0.04818 non-essential 0.12427 non-essential high NA high_confidence_nonessential NP_215928.1 82.4 0.31434 66.517 Strong candidate ESM-2 calibrated P(essential)=0.048; HANSEN integrated essentiality score=0.124; ProteomeLM contextual percentile=0.314; target-priority score=66.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1213 ML1234 P54200 fadD21 masC ML1234 Putative fatty-acid--CoA ligase fadD21 (EC 6.2.1.-) (Acyl-CoA synthetase) 579 0.09148 non-essential 0.12426 non-essential high NA high_confidence_nonessential NP_215701.1 72.4 0.14966 54.923 Moderate candidate ESM-2 calibrated P(essential)=0.091; HANSEN integrated essentiality score=0.124; ProteomeLM contextual percentile=0.150; target-priority score=54.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1214 ML2491 Q9CB25 ML2491 DUF4185 domain-containing protein 333 0.01019 non-essential 0.12408 non-essential high agree high_confidence_nonessential Rv1754c 70.8 NE 0 0.82029 71.876 Strong candidate ESM-2 calibrated P(essential)=0.010; HANSEN integrated essentiality score=0.124; Mtb RBH anchor Rv1754c=non-essential (agree); ProteomeLM contextual percentile=0.820; target-priority score=71.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1215 ML2406 O07134 menA ML2406 MLB1306.02c 1,4-dihydroxy-2-naphthoate octaprenyltransferase (DHNA-octaprenyltransferase) (EC 2.5.1.74) 294 0.02518 non-essential 0.12403 non-essential high NA high_confidence_nonessential NP_215048.1 81.1 0.40827 69.982 Strong candidate ESM-2 calibrated P(essential)=0.025; HANSEN integrated essentiality score=0.124; ProteomeLM contextual percentile=0.408; target-priority score=70.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1216 ML1338 Q7AQ64 ML1338 Possible conserved integral membrane protein 440 0.01889 non-essential 0.12399 non-essential high NA high_confidence_nonessential NP_217189.1 82.3 0.46212 61.404 Moderate candidate ESM-2 calibrated P(essential)=0.019; HANSEN integrated essentiality score=0.124; ProteomeLM contextual percentile=0.462; target-priority score=61.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1217 ML1559 Q9Z5J2 rimP ML1559 MLCB596.11 Putative ribosome maturation factor RimP 150 0.01761 non-essential 0.12373 non-essential high NA high_confidence_nonessential NP_217358.1 52.5 0.5 ESM-2 calibrated P(essential)=0.018; HANSEN integrated essentiality score=0.124; ProteomeLM contextual percentile=0.500 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1218 ML2023 Q7AQ02 ML2023 Secreted protein 134 0.01019 non-essential 0.1233 non-essential high agree high_confidence_nonessential Rv1891 76.7 NE 0 0.82154 70.059 Strong candidate ESM-2 calibrated P(essential)=0.010; HANSEN integrated essentiality score=0.123; Mtb RBH anchor Rv1891=non-essential (agree); ProteomeLM contextual percentile=0.822; target-priority score=70.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1219 ML0899 Q7AQD1 ML0899 Alpha-(1->6)-mannopyranosyltransferase A 505 0.04234 non-essential 0.12322 non-essential high NA high_confidence_nonessential NP_216690.1 78.9 0.35942 58.188 Moderate candidate ESM-2 calibrated P(essential)=0.042; HANSEN integrated essentiality score=0.123; ProteomeLM contextual percentile=0.359; target-priority score=58.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1220 ML2118 Q50130 echA6 ML2118 u650af Probable enoyl-CoA hydratase echA6 (EC 4.2.1.17) 247 0.06981 non-essential 0.12303 non-essential high NA high_confidence_nonessential NP_215420.1 85.8 0.22793 59.665 Moderate candidate ESM-2 calibrated P(essential)=0.070; HANSEN integrated essentiality score=0.123; ProteomeLM contextual percentile=0.228; target-priority score=59.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1221 ML1412 Q9CC10 argG ML1412 Argininosuccinate synthase (EC 6.3.4.5) (Citrulline--aspartate ligase) 399 0.10418 non-essential 0.12301 non-essential high NA high_confidence_nonessential NP_216174.1 91.0 0.07013 59.659 Moderate candidate ESM-2 calibrated P(essential)=0.104; HANSEN integrated essentiality score=0.123; ProteomeLM contextual percentile=0.070; target-priority score=59.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1222 ML0270 Q7AQK7 ML0270 Metallo-beta-lactamase domain-containing protein 251 0.02734 non-essential 0.12301 non-essential high NA high_confidence_nonessential NP_214920.1 74.9 0.42768 57.95 Moderate candidate ESM-2 calibrated P(essential)=0.027; HANSEN integrated essentiality score=0.123; ProteomeLM contextual percentile=0.428; target-priority score=58.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1223 ML0834 Q9CCG1 ML0834 Uncharacterized protein 100 0.01648 non-essential 0.12276 non-essential high agree high_confidence_nonessential Rv2342 76.9 NE 0 0.80276 65.198 Strong candidate ESM-2 calibrated P(essential)=0.016; HANSEN integrated essentiality score=0.123; Mtb RBH anchor Rv2342=non-essential (agree); ProteomeLM contextual percentile=0.803; target-priority score=65.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1224 ML2600 Q9CD04 ML2600 Probable conserved membrane protein 465 0.00543 non-essential 0.12262 non-essential high NA high_confidence_nonessential NP_214694.1 77.4 0.51597 61.334 Moderate candidate ESM-2 calibrated P(essential)=0.005; HANSEN integrated essentiality score=0.123; ProteomeLM contextual percentile=0.516; target-priority score=61.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1225 ML0154 Q9CD71 ML0154 M23ase beta-sheet core domain-containing protein 333 0.00543 non-essential 0.12243 non-essential high agree high_confidence_nonessential Rv0950c 71.0 NE 0 0.84158 70.028 Strong candidate ESM-2 calibrated P(essential)=0.005; HANSEN integrated essentiality score=0.122; Mtb RBH anchor Rv0950c=non-essential (agree); ProteomeLM contextual percentile=0.842; target-priority score=70.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1226 ML2670 Q9CCY5 ML2670 Conserved integral membrane protein 666 0.03604 non-essential 0.12242 non-essential high NA high_confidence_nonessential NP_214625.1 78.7 0.38259 58.536 Moderate candidate ESM-2 calibrated P(essential)=0.036; HANSEN integrated essentiality score=0.122; ProteomeLM contextual percentile=0.383; target-priority score=58.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1227 ML1389 Q9CC27 ML1389 Conserved membrane protein 527 0.02688 non-essential 0.12238 non-essential high NA high_confidence_nonessential NP_216151.1 71.4 0.42079 59.747 Moderate candidate ESM-2 calibrated P(essential)=0.027; HANSEN integrated essentiality score=0.122; ProteomeLM contextual percentile=0.421; target-priority score=59.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1228 ML1463 Q9CBZ6 nadE ML1463 Glutamine-dependent NAD(+) synthetase (EC 6.3.5.1) (NAD(+) synthase [glutamine-hydrolyzing]) 680 0.1 non-essential 0.12229 non-essential high NA high_confidence_nonessential NP_216954.2 84.5 0.0789 61.758 Moderate candidate ESM-2 calibrated P(essential)=0.100; HANSEN integrated essentiality score=0.122; ProteomeLM contextual percentile=0.079; target-priority score=61.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1229 ML2279 Q9CBA3 ML2279 Transmembrane transport protein 496 0.01019 non-essential 0.12222 non-essential high NA high_confidence_nonessential NP_217790.1 53.0 0.49468 60.351 Moderate candidate ESM-2 calibrated P(essential)=0.010; HANSEN integrated essentiality score=0.122; ProteomeLM contextual percentile=0.495; target-priority score=60.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1230 ML0919 Q9CCE2 ML0919 Pyridoxal phosphate homeostasis protein (PLP homeostasis protein) 257 0.04818 non-essential 0.12207 non-essential high agree high_confidence_nonessential Rv2148c 73.6 NE 0 0.60488 65.347 Strong candidate ESM-2 calibrated P(essential)=0.048; HANSEN integrated essentiality score=0.122; Mtb RBH anchor Rv2148c=non-essential (agree); ProteomeLM contextual percentile=0.605; target-priority score=65.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1231 ML2270 Q9CBB0 menD ML2270 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase (SEPHCHC synthase) (EC 2.2.1.9) (Menaquinone biosynthesis protein MenD) 556 0.03604 non-essential 0.12197 non-essential high NA high_confidence_nonessential NP_215069.1 85.4 0.35254 67.855 Strong candidate ESM-2 calibrated P(essential)=0.036; HANSEN integrated essentiality score=0.122; ProteomeLM contextual percentile=0.353; target-priority score=67.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1232 ML0554 Q9CCP9 rpe ML0554 Ribulose-phosphate 3-epimerase (EC 5.1.3.1) 224 0.06652 non-essential 0.1218 non-essential high NA high_confidence_nonessential NP_215924.1 91.0 0.21979 65.107 Strong candidate ESM-2 calibrated P(essential)=0.067; HANSEN integrated essentiality score=0.122; ProteomeLM contextual percentile=0.220; target-priority score=65.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1233 ML0696 Q7AQF9 sdhB ML0696 succinate dehydrogenase (EC 1.3.5.1) 264 0.08231 non-essential 0.12165 non-essential high NA high_confidence_nonessential NP_217836.1 89.8 0.1747 55.499 Moderate candidate ESM-2 calibrated P(essential)=0.082; HANSEN integrated essentiality score=0.122; ProteomeLM contextual percentile=0.175; target-priority score=55.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1234 ML1407 Q9CC14 argJ ML1407 Arginine biosynthesis bifunctional protein ArgJ [Cleaved into: Arginine biosynthesis bifunctional protein ArgJ alpha chain; Arginine biosynthesis bifunctional protein ArgJ beta chain] [Includes: Glutamate N-acetyltransferase (EC 2.3.1.35) (Ornithine acetyltransferase) (OATase) (Ornithine transacetylase); Amino-acid acetyltransferase (EC 2.3.1.1) (N-acetylglutamate synthase) (AGSase)] 407 0.03769 non-essential 0.12165 non-essential high NA high_confidence_nonessential NP_216169.1 82.4 0.33939 69.118 Strong candidate ESM-2 calibrated P(essential)=0.038; HANSEN integrated essentiality score=0.122; ProteomeLM contextual percentile=0.339; target-priority score=69.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1235 ML1340 Q7AQ62 ML1340 Possible reductase 268 0.06116 non-essential 0.12162 non-essential high NA high_confidence_nonessential NP_217187.1 72.9 0.26237 58.63 Moderate candidate ESM-2 calibrated P(essential)=0.061; HANSEN integrated essentiality score=0.122; ProteomeLM contextual percentile=0.262; target-priority score=58.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1236 ML1899 Q9CBK5 lipG ML1899 Probable hydrolase 304 0.0515 non-essential 0.12157 non-essential high NA high_confidence_nonessential NP_215160.1 71.6 0.31121 56.988 Moderate candidate ESM-2 calibrated P(essential)=0.051; HANSEN integrated essentiality score=0.122; ProteomeLM contextual percentile=0.311; target-priority score=57.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1237 ML1713 Q7AQ25 ML1713 Methyltransferase type 11 domain-containing protein 280 0.04552 non-essential 0.12128 non-essential high NA high_confidence_nonessential NP_217546.1 77.8 0.33813 56.569 Moderate candidate ESM-2 calibrated P(essential)=0.046; HANSEN integrated essentiality score=0.121; ProteomeLM contextual percentile=0.338; target-priority score=56.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1238 ML0518 Q9CCS4 aroB ML0518 3-dehydroquinate synthase (DHQS) (EC 4.2.3.4) 361 0.09148 non-essential 0.12118 non-essential high NA high_confidence_nonessential NP_217054.1 87.3 0.11083 61.967 Moderate candidate ESM-2 calibrated P(essential)=0.091; HANSEN integrated essentiality score=0.121; ProteomeLM contextual percentile=0.111; target-priority score=62.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1239 ML2211 Q50023 purL ML2211 MLCB5.30 Phosphoribosylformylglycinamidine synthase subunit PurL (FGAM synthase) (EC 6.3.5.3) (Formylglycinamide ribonucleotide amidotransferase subunit II) (FGAR amidotransferase II) (FGAR-AT II) (Glutamine amidotransferase PurL) (Phosphoribosylformylglycinamidine synthase subunit II) 754 0.09638 non-essential 0.12095 non-essential high NA high_confidence_nonessential NP_215318.1 90.5 0.09393 59.615 Moderate candidate ESM-2 calibrated P(essential)=0.096; HANSEN integrated essentiality score=0.121; ProteomeLM contextual percentile=0.094; target-priority score=59.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1240 ML0370 Q9CCV6 ML0370 Alpha/beta hydrolase 289 0.0533 non-essential 0.12094 non-essential high agree high_confidence_nonessential Rv3438 80.6 GA 0 0.57107 63.701 Moderate candidate ESM-2 calibrated P(essential)=0.053; HANSEN integrated essentiality score=0.121; Mtb RBH anchor Rv3438=non-essential (agree); ProteomeLM contextual percentile=0.571; target-priority score=63.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1241 ML2704 Q9CCX8 ML2704 Hydrolase 406 0.10115 non-essential 0.12081 non-essential high NA high_confidence_nonessential YP_178027.1 86.9 0.10081 49.549 Exploratory ESM-2 calibrated P(essential)=0.101; HANSEN integrated essentiality score=0.121; ProteomeLM contextual percentile=0.101; target-priority score=49.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1242 ML1518 Q9CBW1 folA ML1518 Dihydrofolate reductase (EC 1.5.1.3) 165 0.04818 non-essential 0.12076 non-essential high NA high_confidence_nonessential NP_217279.1 70.6 0.28366 69.914 Strong candidate ESM-2 calibrated P(essential)=0.048; HANSEN integrated essentiality score=0.121; ProteomeLM contextual percentile=0.284; target-priority score=69.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1243 ML2073 Q7APZ6 ML2073 HTH merR-type domain-containing protein 231 0.06981 non-essential 0.12075 non-essential high NA high_confidence_nonessential NP_216346.1 89.2 0.24108 50.629 Moderate candidate ESM-2 calibrated P(essential)=0.070; HANSEN integrated essentiality score=0.121; ProteomeLM contextual percentile=0.241; target-priority score=50.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1244 ML2326 Q7APW6 murT ML2326 Lipid II isoglutaminyl synthase (glutamine-hydrolyzing) subunit MurT (EC 6.3.5.13) 411 0.11406 non-essential 0.12063 non-essential high NA high_confidence_nonessential NP_218229.1 84.1 0.01064 59.707 Moderate candidate ESM-2 calibrated P(essential)=0.114; HANSEN integrated essentiality score=0.121; ProteomeLM contextual percentile=0.011; target-priority score=59.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1245 ML1684 O33124 leuD ML1684 MLCB637.33 3-isopropylmalate dehydratase small subunit (EC 4.2.1.33) (Alpha-IPM isomerase) (IPMI) (Isopropylmalate isomerase) 198 0.02105 non-essential 0.12038 non-essential high NA high_confidence_nonessential NP_217503.1 87.8 0.40952 68.686 Strong candidate ESM-2 calibrated P(essential)=0.021; HANSEN integrated essentiality score=0.120; ProteomeLM contextual percentile=0.410; target-priority score=68.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1246 ML0872 Q9CCF4 ML0872 Membrane protein 171 0.07374 non-essential 0.1201 non-essential high NA high_confidence_nonessential NP_216719.1 72.4 0.22292 49.377 Exploratory ESM-2 calibrated P(essential)=0.074; HANSEN integrated essentiality score=0.120; ProteomeLM contextual percentile=0.223; target-priority score=49.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1247 ML0606 Q49770 ML0606 DUF403 domain-containing protein 325 0.02795 non-essential 0.11998 non-essential high agree high_confidence_nonessential Rv2410c 90.8 NE 0 0.69881 66.664 Strong candidate ESM-2 calibrated P(essential)=0.028; HANSEN integrated essentiality score=0.120; Mtb RBH anchor Rv2410c=non-essential (agree); ProteomeLM contextual percentile=0.699; target-priority score=66.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1248 ML1952 Q7AQ11 desA2 ML1952 Acyl-[ACP] desaturase 275 0.03424 non-essential 0.1199 non-essential high NA high_confidence_nonessential NP_215610.1 78.1 0.36756 61.415 Moderate candidate ESM-2 calibrated P(essential)=0.034; HANSEN integrated essentiality score=0.120; ProteomeLM contextual percentile=0.368; target-priority score=61.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1249 ML1061 Q7AQ98 ML1061 Cytokinin riboside 5'-monophosphate phosphoribohydrolase (EC 3.2.2.n1) 187 0.06981 non-essential 0.11967 non-essential high agree high_confidence_nonessential Rv1205 72.4 NE 0 0.44458 66.643 Strong candidate ESM-2 calibrated P(essential)=0.070; HANSEN integrated essentiality score=0.120; Mtb RBH anchor Rv1205=non-essential (agree); ProteomeLM contextual percentile=0.445; target-priority score=66.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1250 ML0452 O07147 pimA ML0452 MLCL581.14c Phosphatidyl-myo-inositol mannosyltransferase (EC 2.4.1.345) (Alpha-mannosyltransferase) (GDP-mannose-dependent alpha-(1-2)-phosphatidylinositol mannosyltransferase) (Guanosine diphosphomannose-phosphatidyl-inositol alpha-mannosyltransferase) (Phosphatidylinositol alpha-mannosyltransferase) (PI alpha-mannosyltransferase) 374 0.11185 non-essential 0.11959 non-essential high NA high_confidence_nonessential NP_217126.1 82.3 0.01941 58.09 Moderate candidate ESM-2 calibrated P(essential)=0.112; HANSEN integrated essentiality score=0.120; ProteomeLM contextual percentile=0.019; target-priority score=58.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1251 ML1136 P45831 ML1136 Putative threonylcarbamoyl-AMP synthase (TC-AMP synthase) (EC 2.7.7.87) (L-threonylcarbamoyladenylate synthase) (tRNA threonylcarbamoyladenosine biosynthesis protein ML1136) 220 0.04552 non-essential 0.1195 non-essential high NA high_confidence_nonessential NP_215817.1 83.3 0.30808 63.24 Moderate candidate ESM-2 calibrated P(essential)=0.046; HANSEN integrated essentiality score=0.120; ProteomeLM contextual percentile=0.308; target-priority score=63.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1252 ML0066 Q9CDD2 ML0066 Putative 4-hydroxy-4-methyl-2-oxoglutarate aldolase (HMG aldolase) (EC 4.1.3.17) (Oxaloacetate decarboxylase) (OAA decarboxylase) (EC 4.1.1.112) (Regulator of ribonuclease activity homolog) (RraA-like protein) 157 0.00543 non-essential 0.11921 non-essential high NA high_confidence_nonessential NP_218370.1 86.6 0.46838 70.711 Strong candidate ESM-2 calibrated P(essential)=0.005; HANSEN integrated essentiality score=0.119; ProteomeLM contextual percentile=0.468; target-priority score=70.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1253 ML1363 P53529 pyrG ML1363 MLC1351.09c CTP synthase (EC 6.3.4.2) (Cytidine 5'-triphosphate synthase) (Cytidine triphosphate synthetase) (CTP synthetase) (CTPS) (UTP--ammonia ligase) 590 0.10418 non-essential 0.11902 non-essential high NA high_confidence_nonessential NP_216215.1 89.3 0.05072 58.271 Moderate candidate ESM-2 calibrated P(essential)=0.104; HANSEN integrated essentiality score=0.119; ProteomeLM contextual percentile=0.051; target-priority score=58.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1254 ML0643 Q9CCM7 ML0643 endopeptidase La (EC 3.4.21.53) 340 0.09059 non-essential 0.11889 non-essential high agree high_confidence_nonessential Rv3194c 80.6 NE 0 0.3206 64.95 Moderate candidate ESM-2 calibrated P(essential)=0.091; HANSEN integrated essentiality score=0.119; Mtb RBH anchor Rv3194c=non-essential (agree); ProteomeLM contextual percentile=0.321; target-priority score=65.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1255 ML2200 Q9CBC6 ML2200 Ferric nitrobindin-like protein 228 0.03949 non-essential 0.11828 non-essential high agree high_confidence_nonessential Rv0813c 87.4 GA 0 0.62555 64.073 Moderate candidate ESM-2 calibrated P(essential)=0.039; HANSEN integrated essentiality score=0.118; Mtb RBH anchor Rv0813c=non-essential (agree); ProteomeLM contextual percentile=0.626; target-priority score=64.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1256 ML0031 O33075 ML0031 MLB1770.19c MLCB628.02c Proline-rich 28 kDa antigen homolog 278 0.03424 non-essential 0.11825 non-essential high agree high_confidence_nonessential Rv0040c 63.7 NE 0 0.66061 63.292 Moderate candidate ESM-2 calibrated P(essential)=0.034; HANSEN integrated essentiality score=0.118; Mtb RBH anchor Rv0040c=non-essential (agree); ProteomeLM contextual percentile=0.661; target-priority score=63.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1257 ML1339 Q7AQ63 ML1339 Secreted protease 525 0.06981 non-essential 0.11824 non-essential high NA high_confidence_nonessential NP_217188.1 73.3 0.21916 53.065 Moderate candidate ESM-2 calibrated P(essential)=0.070; HANSEN integrated essentiality score=0.118; ProteomeLM contextual percentile=0.219; target-priority score=53.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1258 ML1707 O33099 mnmA trmU ML1707 MLCB637.07 tRNA-specific 2-thiouridylase MnmA (EC 2.8.1.13) 358 0.06981 non-essential 0.11817 non-essential high NA high_confidence_nonessential NP_217540.1 85.4 0.19724 60.375 Moderate candidate ESM-2 calibrated P(essential)=0.070; HANSEN integrated essentiality score=0.118; ProteomeLM contextual percentile=0.197; target-priority score=60.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1259 ML2124 O33071 prrB ML2124 MLCB57.60c Sensor-type histidine kinase PrrB (EC 2.7.13.3) 446 0.05001 non-essential 0.1181 non-essential high NA high_confidence_nonessential NP_215417.1 92.4 0.28929 59.829 Moderate candidate ESM-2 calibrated P(essential)=0.050; HANSEN integrated essentiality score=0.118; ProteomeLM contextual percentile=0.289; target-priority score=59.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1260 ML0564 Q9CCN9 ML0564 Putative gluconeogenesis factor 359 0.05422 non-essential 0.11809 non-essential high agree high_confidence_nonessential Rv1422 85.7 NE 0 0.53601 63.921 Moderate candidate ESM-2 calibrated P(essential)=0.054; HANSEN integrated essentiality score=0.118; Mtb RBH anchor Rv1422=non-essential (agree); ProteomeLM contextual percentile=0.536; target-priority score=63.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1261 ML0817 Q9CCG8 moeZ ML0817 Probable adenylyltransferase/sulfurtransferase MoeZ 395 0.09148 non-essential 0.11806 non-essential high NA high_confidence_nonessential YP_177942.1 86.4 0.12837 49.771 Exploratory ESM-2 calibrated P(essential)=0.091; HANSEN integrated essentiality score=0.118; ProteomeLM contextual percentile=0.128; target-priority score=49.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1262 ML0879 P15878 qcrB mla12A ML0879 Cytochrome bc1 complex cytochrome b subunit (EC 7.1.1.8) (Cytochrome bc1 reductase complex subunit QcrB) (Ubiquinol--cytochrome c reductase cytochrome b subunit) 551 0.0582 non-essential 0.11805 non-essential high NA high_confidence_nonessential NP_216712.1 92.5 0.24734 61.211 Moderate candidate ESM-2 calibrated P(essential)=0.058; HANSEN integrated essentiality score=0.118; ProteomeLM contextual percentile=0.247; target-priority score=61.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1263 ML2210 Q7APX5 ML2210 Calcineurin-like phosphoesterase domain-containing protein 317 0.02734 non-essential 0.11798 non-essential high NA high_confidence_nonessential NP_215320.1 82.9 0.39699 58.337 Moderate candidate ESM-2 calibrated P(essential)=0.027; HANSEN integrated essentiality score=0.118; ProteomeLM contextual percentile=0.397; target-priority score=58.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1264 ML0804 Q9CCH7 whiB1 whiB ML0804 Transcriptional regulator WhiB 84 0.07333 non-essential 0.11793 non-essential high NA high_confidence_nonessential NP_217735.1 95.2 0.19411 55.472 Moderate candidate ESM-2 calibrated P(essential)=0.073; HANSEN integrated essentiality score=0.118; ProteomeLM contextual percentile=0.194; target-priority score=55.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1265 ML0578 P46710 ppc ML0578 B1496_C3_207 Phosphoenolpyruvate carboxylase (PEPC) (PEPCase) (EC 4.1.1.31) 934 0.09928 non-essential 0.11774 non-essential high NA high_confidence_nonessential 0.07451 55.27 Moderate candidate ESM-2 calibrated P(essential)=0.099; HANSEN integrated essentiality score=0.118; ProteomeLM contextual percentile=0.075; target-priority score=55.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:45Z 1266 ML1025 Q7AQB0 ML1025 Possible secreted protein 216 0.06849 non-essential 0.1175 non-essential high agree high_confidence_nonessential Rv2700 82.9 NE 0 0.47339 58.135 Moderate candidate ESM-2 calibrated P(essential)=0.068; HANSEN integrated essentiality score=0.117; Mtb RBH anchor Rv2700=non-essential (agree); ProteomeLM contextual percentile=0.473; target-priority score=58.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1267 ML1095 Q9CC97 kgd ML1095 Multifunctional 2-oxoglutarate metabolism enzyme (2-hydroxy-3-oxoadipate synthase) (HOA synthase) (HOAS) (EC 2.2.1.5) (2-oxoglutarate carboxy-lyase) (2-oxoglutarate decarboxylase) (Alpha-ketoglutarate decarboxylase) (KG decarboxylase) (KGD) (EC 4.1.1.71) (Alpha-ketoglutarate-glyoxylate carboligase) [Includes: 2-oxoglutarate dehydrogenase E1 component (ODH E1 component) (EC 1.2.4.2) (Alpha-ketoglutarate dehydrogenase E1 component) (KDH E1 component); Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex (EC 2.3.1.61) (2-oxoglutarate dehydrogenase complex E2 component) (ODH E2 component) (OGDC-E2) (Dihydrolipoamide succinyltransferase)] 1238 0.10115 non-essential 0.11749 non-essential high NA high_confidence_nonessential NP_215764.2 90.5 0.05949 56.974 Moderate candidate ESM-2 calibrated P(essential)=0.101; HANSEN integrated essentiality score=0.117; ProteomeLM contextual percentile=0.059; target-priority score=57.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:45Z 1268 ML0752 Q9CCK7 wbbL ML0752 N-acetylglucosaminyl-diphospho-decaprenol L-rhamnosyltransferase (EC 2.4.1.289) (Rhamnosyltransferase WbbL) (dTDP-Rha:alpha-D-GlcNAc-pyrophosphate polyprenol, alpha-3-L-rhamnosyltransferase) 308 0.06199 non-essential 0.11739 non-essential high NA high_confidence_nonessential YP_177952.3 84.7 0.23356 58.677 Moderate candidate ESM-2 calibrated P(essential)=0.062; HANSEN integrated essentiality score=0.117; ProteomeLM contextual percentile=0.234; target-priority score=58.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1269 ML0818 Q9CCG7 ML0818 Aminoglycoside phosphotransferase domain-containing protein 297 0.03424 non-essential 0.11734 non-essential high agree high_confidence_nonessential Rv3205c 87.3 NE 0 0.63619 66.364 Strong candidate ESM-2 calibrated P(essential)=0.034; HANSEN integrated essentiality score=0.117; Mtb RBH anchor Rv3205c=non-essential (agree); ProteomeLM contextual percentile=0.636; target-priority score=66.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1270 ML0311 Q9CCW9 psd ML0311 MLCB1450.11 Phosphatidylserine decarboxylase proenzyme (EC 4.1.1.65) [Cleaved into: Phosphatidylserine decarboxylase alpha chain; Phosphatidylserine decarboxylase beta chain] 243 0.03604 non-essential 0.11726 non-essential high NA high_confidence_nonessential NP_214951.1 73.0 0.32248 68.664 Strong candidate ESM-2 calibrated P(essential)=0.036; HANSEN integrated essentiality score=0.117; ProteomeLM contextual percentile=0.322; target-priority score=68.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1271 ML1900 Q9CBK4 mmaA1 ML1900 Methyl mycolic acid synthase 1 286 0.06981 non-essential 0.11691 non-essential high NA high_confidence_nonessential NP_215159.1 87.4 0.20225 56.159 Moderate candidate ESM-2 calibrated P(essential)=0.070; HANSEN integrated essentiality score=0.117; ProteomeLM contextual percentile=0.202; target-priority score=56.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1272 ML1538 Q9CBV3 ML1538 Possible protease 567 0.09724 non-essential 0.11681 non-essential high NA high_confidence_nonessential NP_216312.1 69.9 0.09518 49.568 Exploratory ESM-2 calibrated P(essential)=0.097; HANSEN integrated essentiality score=0.117; ProteomeLM contextual percentile=0.095; target-priority score=49.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1273 ML0493 Q49649 ML0493 B1177_C3_247 MLCB1259.11 Uncharacterized protein ML0493 (EC 3.-.-.-) 218 0.09359 non-essential 0.1167 non-essential high NA high_confidence_nonessential NP_217097.1 82.4 0.0958 54.822 Moderate candidate ESM-2 calibrated P(essential)=0.094; HANSEN integrated essentiality score=0.117; ProteomeLM contextual percentile=0.096; target-priority score=54.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1274 ML0366 Q49869 glmM ML0366 Phosphoglucosamine mutase (EC 5.4.2.10) 463 0.09206 non-essential 0.11576 non-essential high NA high_confidence_nonessential NP_217958.1 87.6 0.08954 57.466 Moderate candidate ESM-2 calibrated P(essential)=0.092; HANSEN integrated essentiality score=0.116; ProteomeLM contextual percentile=0.090; target-priority score=57.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1275 ML1401 Q9CC17 pheS ML1401 Phenylalanine--tRNA ligase alpha subunit (EC 6.1.1.20) (Phenylalanyl-tRNA synthetase alpha subunit) (PheRS) 341 0.05242 non-essential 0.11556 non-essential high NA high_confidence_nonessential NP_216165.3 85.0 0.25297 63.324 Moderate candidate ESM-2 calibrated P(essential)=0.052; HANSEN integrated essentiality score=0.116; ProteomeLM contextual percentile=0.253; target-priority score=63.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1276 ML0756 Q9CCK4 ML0756 site-specific DNA-methyltransferase (adenine-specific) (EC 2.1.1.72) 555 0.04041 non-essential 0.11553 non-essential high NA high_confidence_nonessential NP_217780.1 81.9 0.31309 61.558 Moderate candidate ESM-2 calibrated P(essential)=0.040; HANSEN integrated essentiality score=0.116; ProteomeLM contextual percentile=0.313; target-priority score=61.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1277 ML1802 Q9CBM5 ML1802 Band 7 domain-containing protein 374 0.09564 non-essential 0.11548 non-essential high agree high_confidence_nonessential Rv1488 89.8 NE 0 0.31622 52.948 Moderate candidate ESM-2 calibrated P(essential)=0.096; HANSEN integrated essentiality score=0.115; Mtb RBH anchor Rv1488=non-essential (agree); ProteomeLM contextual percentile=0.316; target-priority score=52.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1278 ML0389 Q9CCV1 choD ML0389 Cholesterol oxidase (EC 1.1.3.6) (EC 5.3.3.1) (Cholesterol isomerase) 569 0.07935 non-essential 0.11542 non-essential high NA high_confidence_nonessential NP_217926.1 88.6 0.14527 57.663 Moderate candidate ESM-2 calibrated P(essential)=0.079; HANSEN integrated essentiality score=0.115; ProteomeLM contextual percentile=0.145; target-priority score=57.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1279 ML0608 Q49744 rnz ML0608 B1937_C1_163 MLCL536.01 Putative ribonuclease Z (RNase Z) (tRNase Z) (EC 3.1.26.11) (tRNA 3 endonuclease) 220 0.00674 non-essential 0.11526 non-essential high NA high_confidence_nonessential NP_216923.1 61.6 0.5 ESM-2 calibrated P(essential)=0.007; HANSEN integrated essentiality score=0.115; ProteomeLM contextual percentile=0.500 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1280 ML1138 P53431 ML1138 u471d Uncharacterized protein ML1138 153 0.06766 non-essential 0.11491 non-essential high agree high_confidence_nonessential Rv1303 69.7 NE 0 0.4521 58.205 Moderate candidate ESM-2 calibrated P(essential)=0.068; HANSEN integrated essentiality score=0.115; Mtb RBH anchor Rv1303=non-essential (agree); ProteomeLM contextual percentile=0.452; target-priority score=58.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1281 ML1464 Q9CBZ5 proB ML1464 Glutamate 5-kinase (EC 2.7.2.11) (Gamma-glutamyl kinase) (GK) 367 0.09178 non-essential 0.11488 non-essential high NA high_confidence_nonessential NP_216955.1 84.4 0.08078 59.112 Moderate candidate ESM-2 calibrated P(essential)=0.092; HANSEN integrated essentiality score=0.115; ProteomeLM contextual percentile=0.081; target-priority score=59.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1282 ML0915 P57994 murC ML0915 UDP-N-acetylmuramate--L-alanine ligase (EC 6.3.2.8) (UDP-N-acetylmuramoyl-L-alanine synthetase) 495 0.04656 non-essential 0.11487 non-essential high NA high_confidence_nonessential NP_216668.1 79.3 0.25861 69.187 Strong candidate ESM-2 calibrated P(essential)=0.047; HANSEN integrated essentiality score=0.115; ProteomeLM contextual percentile=0.259; target-priority score=69.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1283 ML0315 Q7AQJ6 ML0315 Oxidoreductase 304 0.03604 non-essential 0.11486 non-essential high NA high_confidence_nonessential NP_214582.1 73.9 0.34064 57.68 Moderate candidate ESM-2 calibrated P(essential)=0.036; HANSEN integrated essentiality score=0.115; ProteomeLM contextual percentile=0.341; target-priority score=57.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1284 ML0793 Q9CCI2 ML0793 Abasic site processing protein (EC 3.4.-.-) 252 0.02448 non-essential 0.11483 non-essential high agree high_confidence_nonessential Rv3226c 70.9 NE 0 0.64496 71.295 Strong candidate ESM-2 calibrated P(essential)=0.024; HANSEN integrated essentiality score=0.115; Mtb RBH anchor Rv3226c=non-essential (agree); ProteomeLM contextual percentile=0.645; target-priority score=71.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1285 ML2199 Q9CBC7 ML2199 DUF1416 domain-containing protein 100 0.06391 non-essential 0.11474 non-essential high agree high_confidence_nonessential Rv0814c 84.0 GA 0 0.47464 57.856 Moderate candidate ESM-2 calibrated P(essential)=0.064; HANSEN integrated essentiality score=0.115; Mtb RBH anchor Rv0814c=non-essential (agree); ProteomeLM contextual percentile=0.475; target-priority score=57.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1286 ML2549 Q9CD26 ML2549 Carboxyltransferase domain-containing protein 222 0.03604 non-essential 0.11458 non-essential high agree high_confidence_nonessential Rv0264c 75.2 NE 0 0.59987 65.934 Strong candidate ESM-2 calibrated P(essential)=0.036; HANSEN integrated essentiality score=0.115; Mtb RBH anchor Rv0264c=non-essential (agree); ProteomeLM contextual percentile=0.600; target-priority score=65.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1287 ML0912 P57995 murD ML0912 MLCB268.04c UDP-N-acetylmuramoylalanine--D-glutamate ligase (EC 6.3.2.9) (D-glutamic acid-adding enzyme) (UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase) 490 0.06981 non-essential 0.11455 non-essential high NA high_confidence_nonessential NP_216671.3 75.9 0.1603 65.689 Strong candidate ESM-2 calibrated P(essential)=0.070; HANSEN integrated essentiality score=0.115; ProteomeLM contextual percentile=0.160; target-priority score=65.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1288 ML0707 P46862 punA deoD ML0707 L308_F2_56 Purine nucleoside phosphorylase (PNP) (Pu-NPase) (EC 2.4.2.1) (Inosine phosphorylase) (Inosine-guanosine phosphorylase) 268 0.03079 non-essential 0.11454 non-essential high NA high_confidence_nonessential NP_217824.1 82.1 0.33125 68.423 Strong candidate ESM-2 calibrated P(essential)=0.031; HANSEN integrated essentiality score=0.115; ProteomeLM contextual percentile=0.331; target-priority score=68.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1289 ML1590 O33046 frr ML1590 MLCB250.76 Ribosome-recycling factor (RRF) (Ribosome-releasing factor) 185 0.1035 non-essential 0.11436 non-essential high NA high_confidence_nonessential NP_217398.1 90.8 0.05448 48.741 Exploratory ESM-2 calibrated P(essential)=0.104; HANSEN integrated essentiality score=0.114; ProteomeLM contextual percentile=0.054; target-priority score=48.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1290 ML1038 Q50000 dxs tktB ML1038 1-deoxy-D-xylulose-5-phosphate synthase (EC 2.2.1.7) (1-deoxyxylulose-5-phosphate synthase) (DXP synthase) (DXPS) 643 0.05604 non-essential 0.11436 non-essential high NA high_confidence_nonessential YP_177898.1 87.2 0.22605 64.429 Moderate candidate ESM-2 calibrated P(essential)=0.056; HANSEN integrated essentiality score=0.114; ProteomeLM contextual percentile=0.226; target-priority score=64.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1291 ML0255 Q9CD42 eno ML0255 Enolase (EC 4.2.1.11) (2-phospho-D-glycerate hydro-lyase) (2-phosphoglycerate dehydratase) 429 0.04897 non-essential 0.11436 non-essential high NA high_confidence_nonessential NP_215539.1 89.0 0.25423 65.88 Strong candidate ESM-2 calibrated P(essential)=0.049; HANSEN integrated essentiality score=0.114; ProteomeLM contextual percentile=0.254; target-priority score=65.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1292 ML0544 Q9CCQ4 metK ML0544 S-adenosylmethionine synthase (AdoMet synthase) (EC 2.5.1.6) (MAT) (Methionine adenosyltransferase) 403 0.08819 non-essential 0.11433 non-essential high NA high_confidence_nonessential NP_215908.1 91.6 0.09017 60.418 Moderate candidate ESM-2 calibrated P(essential)=0.088; HANSEN integrated essentiality score=0.114; ProteomeLM contextual percentile=0.090; target-priority score=60.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1293 ML0383 Q9CCV3 ML0383 Uncharacterized protein 281 0.02338 non-essential 0.11426 non-essential high agree high_confidence_nonessential Rv3415c 73.6 NE 0 0.67126 66.21 Strong candidate ESM-2 calibrated P(essential)=0.023; HANSEN integrated essentiality score=0.114; Mtb RBH anchor Rv3415c=non-essential (agree); ProteomeLM contextual percentile=0.671; target-priority score=66.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1294 ML2528 Q9CD36 ML2528 Protease 475 0.09552 non-essential 0.1142 non-essential high NA high_confidence_nonessential NP_214805.1 71.9 0.08579 50.209 Moderate candidate ESM-2 calibrated P(essential)=0.096; HANSEN integrated essentiality score=0.114; ProteomeLM contextual percentile=0.086; target-priority score=50.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1295 ML1458 Q9CBZ7 proA ML1458 Gamma-glutamyl phosphate reductase (GPR) (EC 1.2.1.41) (Glutamate-5-semialdehyde dehydrogenase) (Glutamyl-gamma-semialdehyde dehydrogenase) (GSA dehydrogenase) 409 0.05949 non-essential 0.11415 non-essential high NA high_confidence_nonessential NP_216943.1 81.9 0.2129 63.109 Moderate candidate ESM-2 calibrated P(essential)=0.059; HANSEN integrated essentiality score=0.114; ProteomeLM contextual percentile=0.213; target-priority score=63.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1296 ML1706 Q9CBR6 ML1706 Cobalamin-independent methionine synthase MetE C-terminal/archaeal domain-containing protein 337 0.0933 non-essential 0.11398 non-essential high agree high_confidence_nonessential Rv3015c 78.3 NE 0 0.29743 56.513 Moderate candidate ESM-2 calibrated P(essential)=0.093; HANSEN integrated essentiality score=0.114; Mtb RBH anchor Rv3015c=non-essential (agree); ProteomeLM contextual percentile=0.297; target-priority score=56.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1297 ML2667 Q9CCY6 ML2667 Possible membrane transport protein 618 0.03466 non-essential 0.11392 non-essential high NA high_confidence_nonessential 0.34941 54.972 Moderate candidate ESM-2 calibrated P(essential)=0.035; HANSEN integrated essentiality score=0.114; ProteomeLM contextual percentile=0.349; target-priority score=55.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1298 ML0892 Q7AQD7 ML0892 Possible acyltransferase 244 0.10418 non-essential 0.11369 non-essential high NA high_confidence_nonessential NP_216698.1 79.8 0.05385 46.556 Exploratory ESM-2 calibrated P(essential)=0.104; HANSEN integrated essentiality score=0.114; ProteomeLM contextual percentile=0.054; target-priority score=46.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1299 ML0747 Q9CCL1 ctpC ML0747 Manganese-exporting P-type ATPase (EC 7.2.2.22) 725 0.07935 non-essential 0.11356 non-essential high NA high_confidence_nonessential NP_217787.1 85.3 0.13588 57.146 Moderate candidate ESM-2 calibrated P(essential)=0.079; HANSEN integrated essentiality score=0.114; ProteomeLM contextual percentile=0.136; target-priority score=57.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1300 ML0631 Q49768 era ML0631 B1937_F3_102 GTPase Era 300 0.10713 non-essential 0.11355 non-essential high NA high_confidence_nonessential YP_177873.1 81.4 0.03131 49.33 Exploratory ESM-2 calibrated P(essential)=0.107; HANSEN integrated essentiality score=0.114; ProteomeLM contextual percentile=0.031; target-priority score=49.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1301 ML2053 Q9CBF1 ML2053 Probable alcohol dehydrogenase AdhA (EC 1.1.1.1) 335 0.03604 non-essential 0.11347 non-essential high NA high_confidence_nonessential NP_216378.1 84.5 0.31497 63.628 Moderate candidate ESM-2 calibrated P(essential)=0.036; HANSEN integrated essentiality score=0.113; ProteomeLM contextual percentile=0.315; target-priority score=63.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1302 ML1939 Q7AQ17 ML1939 Lipid droplet-associated protein 205 0.03949 non-essential 0.11312 non-essential high agree high_confidence_nonessential Rv1109c 68.1 NE 0 0.598 59.249 Moderate candidate ESM-2 calibrated P(essential)=0.039; HANSEN integrated essentiality score=0.113; Mtb RBH anchor Rv1109c=non-essential (agree); ProteomeLM contextual percentile=0.598; target-priority score=59.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1303 ML2299 Q9CB94 ML2299 Nudix hydrolase domain-containing protein 266 0.03604 non-essential 0.11308 non-essential high agree high_confidence_nonessential Rv3672c 76.4 NE 0 0.5886 65.196 Strong candidate ESM-2 calibrated P(essential)=0.036; HANSEN integrated essentiality score=0.113; Mtb RBH anchor Rv3672c=non-essential (agree); ProteomeLM contextual percentile=0.589; target-priority score=65.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1304 ML0667 O32885 prfB ML0667 MLCB1779.24c Peptide chain release factor 2 (RF-2) 374 0.02734 non-essential 0.11305 non-essential high NA high_confidence_nonessential NP_217621.1 90.1 0.37195 56.993 Moderate candidate ESM-2 calibrated P(essential)=0.027; HANSEN integrated essentiality score=0.113; ProteomeLM contextual percentile=0.372; target-priority score=57.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1305 ML0713 P53435 glpD ML0713 L308_C1_179 Glycerol-3-phosphate dehydrogenase (EC 1.1.5.3) 585 0.09638 non-essential 0.11304 non-essential high NA high_confidence_nonessential NP_217819.1 90.9 0.05886 55.71 Moderate candidate ESM-2 calibrated P(essential)=0.096; HANSEN integrated essentiality score=0.113; ProteomeLM contextual percentile=0.059; target-priority score=55.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1306 ML0169 Q7AQN2 ML0169 DUF1707 domain-containing protein 200 0.03424 non-essential 0.11293 non-essential high agree high_confidence_nonessential Rv0966c 79.5 NE 0 0.60802 63.168 Moderate candidate ESM-2 calibrated P(essential)=0.034; HANSEN integrated essentiality score=0.113; Mtb RBH anchor Rv0966c=non-essential (agree); ProteomeLM contextual percentile=0.608; target-priority score=63.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1307 ML1241 P53526 echA12 ML1241 B1170_C2_224 MLCB1610.01 Probable enoyl-CoA hydratase echA12 (EC 4.2.1.17) 294 0.01019 non-essential 0.11291 non-essential high NA high_confidence_nonessential NP_215988.1 72.0 0.42517 65.359 Strong candidate ESM-2 calibrated P(essential)=0.010; HANSEN integrated essentiality score=0.113; ProteomeLM contextual percentile=0.425; target-priority score=65.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1308 ML2561 Q7APU5 ML2561 Probable oxidoreductase 162 0.0 non-essential 0.11277 non-essential high NA high_confidence_nonessential NP_214759.1 82.0 0.47777 63.106 Moderate candidate ESM-2 calibrated P(essential)=0.000; HANSEN integrated essentiality score=0.113; ProteomeLM contextual percentile=0.478; target-priority score=63.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1309 ML1635 Q9CBT0 panB ML1635 3-methyl-2-oxobutanoate hydroxymethyltransferase (EC 2.1.2.11) (Ketopantoate hydroxymethyltransferase) (KPHMT) 286 0.06686 non-essential 0.11269 non-essential high NA high_confidence_nonessential NP_216741.1 82.5 0.16719 64.232 Moderate candidate ESM-2 calibrated P(essential)=0.067; HANSEN integrated essentiality score=0.113; ProteomeLM contextual percentile=0.167; target-priority score=64.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1310 ML2698 Q7APR7 ML2698 Nudix hydrolase domain-containing protein 251 0.05422 non-essential 0.11263 non-essential high NA high_confidence_nonessential NP_218425.1 76.6 0.25924 52.539 Moderate candidate ESM-2 calibrated P(essential)=0.054; HANSEN integrated essentiality score=0.113; ProteomeLM contextual percentile=0.259; target-priority score=52.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1311 ML0002 P46387 dnaN ML0002 Beta sliding clamp (Beta clamp) (Sliding clamp) (Beta-clamp processivity factor) (DNA polymerase III beta sliding clamp subunit) (DNA polymerase III subunit beta) 399 0.03259 non-essential 0.11256 non-essential high NA high_confidence_nonessential NP_214516.1 80.8 0.34252 57.833 Moderate candidate ESM-2 calibrated P(essential)=0.033; HANSEN integrated essentiality score=0.113; ProteomeLM contextual percentile=0.343; target-priority score=57.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1312 ML0703 Q9CCL8 ML0703 Primosomal protein 423 0.06981 non-essential 0.11254 non-essential high agree high_confidence_nonessential Rv3311 78.5 NE 0 0.42642 56.028 Moderate candidate ESM-2 calibrated P(essential)=0.070; HANSEN integrated essentiality score=0.113; Mtb RBH anchor Rv3311=non-essential (agree); ProteomeLM contextual percentile=0.426; target-priority score=56.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1313 ML1227 P46714 nadC ML1227 B1170_C1_168 Nicotinate-nucleotide pyrophosphorylase [carboxylating] (EC 2.4.2.19) (Quinolinate phosphoribosyltransferase [decarboxylating]) (QAPRTase) 284 0.06981 non-essential 0.11246 non-essential high NA high_confidence_nonessential NP_216112.1 79.2 0.15216 64.276 Moderate candidate ESM-2 calibrated P(essential)=0.070; HANSEN integrated essentiality score=0.112; ProteomeLM contextual percentile=0.152; target-priority score=64.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1314 ML1560 Q7AQ42 ML1560 Uncharacterized protein 178 0.01019 non-essential 0.11226 non-essential high agree high_confidence_nonessential Rv2843 68.5 NE 0 0.73137 66.027 Strong candidate ESM-2 calibrated P(essential)=0.010; HANSEN integrated essentiality score=0.112; Mtb RBH anchor Rv2843=non-essential (agree); ProteomeLM contextual percentile=0.731; target-priority score=66.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1315 ML1453 Q9CBZ9 rsfS ML1453 Ribosomal silencing factor RsfS 129 0.02734 non-essential 0.1122 non-essential high agree high_confidence_nonessential Rv2420c 87.0 NE 0 0.61678 68.238 Strong candidate ESM-2 calibrated P(essential)=0.027; HANSEN integrated essentiality score=0.112; Mtb RBH anchor Rv2420c=non-essential (agree); ProteomeLM contextual percentile=0.617; target-priority score=68.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1316 ML1267 Q7AQ77 ML1267 Antiporter 364 0.00543 non-essential 0.11213 non-essential high NA high_confidence_nonessential NP_216123.1 73.9 0.45836 59.956 Moderate candidate ESM-2 calibrated P(essential)=0.005; HANSEN integrated essentiality score=0.112; ProteomeLM contextual percentile=0.458; target-priority score=60.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1317 ML1127 P45840 argS ML1127 Arginine--tRNA ligase (EC 6.1.1.19) (Arginyl-tRNA synthetase) (ArgRS) 550 0.06371 non-essential 0.11208 non-essential high NA high_confidence_nonessential NP_215808.1 85.1 0.19098 59.837 Moderate candidate ESM-2 calibrated P(essential)=0.064; HANSEN integrated essentiality score=0.112; ProteomeLM contextual percentile=0.191; target-priority score=59.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1318 ML1257 Q9CC57 hisD ML1257 MLCB1610.20 Histidinol dehydrogenase (HDH) (EC 1.1.1.23) 449 0.03769 non-essential 0.11199 non-essential high NA high_confidence_nonessential NP_216115.1 84.8 0.28554 68.11 Strong candidate ESM-2 calibrated P(essential)=0.038; HANSEN integrated essentiality score=0.112; ProteomeLM contextual percentile=0.286; target-priority score=68.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1319 ML0113 Q9CDA1 rfbE ML0113 Glycosyl transferase 283 0.02734 non-essential 0.11188 non-essential high NA high_confidence_nonessential YP_178014.1 81.6 0.35003 62.098 Moderate candidate ESM-2 calibrated P(essential)=0.027; HANSEN integrated essentiality score=0.112; ProteomeLM contextual percentile=0.350; target-priority score=62.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1320 ML0198 Q7AQM5 cspA ML0198 Probable cold shock protein A 67 0.00702 non-essential 0.11175 non-essential high NA high_confidence_nonessential NP_218165.1 97.0 0.45147 59.045 Moderate candidate ESM-2 calibrated P(essential)=0.007; HANSEN integrated essentiality score=0.112; ProteomeLM contextual percentile=0.451; target-priority score=59.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1321 ML0430 Q9CCU4 ML0430 Membrane protein 454 0.00429 non-essential 0.11162 non-essential high NA high_confidence_nonessential NP_217024.1 75.7 0.46149 59.644 Moderate candidate ESM-2 calibrated P(essential)=0.004; HANSEN integrated essentiality score=0.112; ProteomeLM contextual percentile=0.461; target-priority score=59.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1322 ML1983 Q9CBH1 ML1983 Polyketide cyclase 155 0.01172 non-essential 0.11161 non-essential high agree high_confidence_nonessential Rv1919c 72.8 NE 0 0.7082 67.528 Strong candidate ESM-2 calibrated P(essential)=0.012; HANSEN integrated essentiality score=0.112; Mtb RBH anchor Rv1919c=non-essential (agree); ProteomeLM contextual percentile=0.708; target-priority score=67.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1323 ML2185 Q7APY0 desA1 ML2185 Acyl-[ACP] desaturase 338 0.03424 non-essential 0.1114 non-essential high NA high_confidence_nonessential YP_177758.1 79.9 0.32436 59.112 Moderate candidate ESM-2 calibrated P(essential)=0.034; HANSEN integrated essentiality score=0.111; ProteomeLM contextual percentile=0.324; target-priority score=59.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1324 ML0761 Q9CCJ9 ML0761 Exonuclease 167 0.1288 non-essential 0.11136 non-essential high agree high_confidence_nonessential Rv3259 89.2 NE 0 0.11647 44.861 Exploratory ESM-2 calibrated P(essential)=0.129; HANSEN integrated essentiality score=0.111; Mtb RBH anchor Rv3259=non-essential (agree); ProteomeLM contextual percentile=0.116; target-priority score=44.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1325 ML1806 Q9CBM1 inhA ML1806 Enoyl-[acyl-carrier-protein] reductase [NADH] (EC 1.3.1.9) 269 0.07542 non-essential 0.11131 non-essential high NA high_confidence_nonessential NP_216000.1 90.3 0.12023 64.1 Moderate candidate ESM-2 calibrated P(essential)=0.075; HANSEN integrated essentiality score=0.111; ProteomeLM contextual percentile=0.120; target-priority score=64.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1326 ML2031 Q9CBF7 ML2031 Cyclase 151 0.01861 non-essential 0.11111 non-essential high agree high_confidence_nonessential Rv1883c 76.2 GA 0 0.66938 66.001 Strong candidate ESM-2 calibrated P(essential)=0.019; HANSEN integrated essentiality score=0.111; Mtb RBH anchor Rv1883c=non-essential (agree); ProteomeLM contextual percentile=0.669; target-priority score=66.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1327 ML0989 Q49842 miaB ML0989 B2235_C2_195 tRNA-2-methylthio-N(6)-dimethylallyladenosine synthase (EC 2.8.4.3) ((Dimethylallyl)adenosine tRNA methylthiotransferase MiaB) (tRNA-i(6)A37 methylthiotransferase) 517 0.05255 non-essential 0.11101 non-essential high NA high_confidence_nonessential NP_217249.1 80.9 0.23231 61.059 Moderate candidate ESM-2 calibrated P(essential)=0.053; HANSEN integrated essentiality score=0.111; ProteomeLM contextual percentile=0.232; target-priority score=61.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1328 ML0579 Q49700 pgl devB ML0579 B1496_F1_31 6-phosphogluconolactonase (6PGL) (EC 3.1.1.31) 247 0.03604 non-essential 0.11101 non-essential high NA high_confidence_nonessential NP_215961.1 73.2 0.29555 65.317 Strong candidate ESM-2 calibrated P(essential)=0.036; HANSEN integrated essentiality score=0.111; ProteomeLM contextual percentile=0.296; target-priority score=65.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1329 ML0337 Q9CCV9 ML0337 Periplasmic solute-binding proteins 302 0.00543 non-essential 0.11096 non-essential high agree high_confidence_nonessential Rv2059 64.5 NE 0 0.73075 69.247 Strong candidate ESM-2 calibrated P(essential)=0.005; HANSEN integrated essentiality score=0.111; Mtb RBH anchor Rv2059=non-essential (agree); ProteomeLM contextual percentile=0.731; target-priority score=69.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1330 ML1051 Q7AQA2 xclC ML1051 Acyl-CoA synthase 476 0.07017 non-essential 0.1109 non-essential high NA high_confidence_nonessential NP_215709.1 81.5 0.17783 51.877 Moderate candidate ESM-2 calibrated P(essential)=0.070; HANSEN integrated essentiality score=0.111; ProteomeLM contextual percentile=0.178; target-priority score=51.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1331 ML1895 P30763 rplL ML1895 Large ribosomal subunit protein bL12 (50S ribosomal protein L7/L12) 130 0.09314 non-essential 0.11087 non-essential high NA high_confidence_nonessential NP_215166.1 80.0 0.08328 48.123 Exploratory ESM-2 calibrated P(essential)=0.093; HANSEN integrated essentiality score=0.111; ProteomeLM contextual percentile=0.083; target-priority score=48.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1332 ML1573 Q9CBU9 ML1573 Possible amidotransferase 249 0.02518 non-essential 0.11085 non-essential high NA high_confidence_nonessential NP_217375.1 71.5 0.36381 58.732 Moderate candidate ESM-2 calibrated P(essential)=0.025; HANSEN integrated essentiality score=0.111; ProteomeLM contextual percentile=0.364; target-priority score=58.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1333 ML2473 Q9CB33 ML2473 tRNA adenosine deaminase 159 0.03424 non-essential 0.11072 non-essential high agree high_confidence_nonessential Rv3753c 88.6 NE 0 0.58485 63.377 Moderate candidate ESM-2 calibrated P(essential)=0.034; HANSEN integrated essentiality score=0.111; Mtb RBH anchor Rv3753c=non-essential (agree); ProteomeLM contextual percentile=0.585; target-priority score=63.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1334 ML1059 Q9CCB0 dapE ML1059 Succinyl-diaminopimelate desuccinylase (EC 3.5.1.18) 354 0.06981 non-essential 0.1106 non-essential high NA high_confidence_nonessential YP_177796.1 87.0 0.15341 60.147 Moderate candidate ESM-2 calibrated P(essential)=0.070; HANSEN integrated essentiality score=0.111; ProteomeLM contextual percentile=0.153; target-priority score=60.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1335 ML2613 Q7APT3 ML2613 Probable zinc metalloprotease 667 0.04552 non-essential 0.11052 non-essential high NA high_confidence_nonessential NP_214712.1 81.0 0.27802 55.49 Moderate candidate ESM-2 calibrated P(essential)=0.046; HANSEN integrated essentiality score=0.111; ProteomeLM contextual percentile=0.278; target-priority score=55.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1336 ML2261 Q9CBB6 ML2261 VOC domain-containing protein 138 0.02105 non-essential 0.11008 non-essential high agree high_confidence_nonessential Rv0546c 84.7 NE 0 0.65435 64.02 Moderate candidate ESM-2 calibrated P(essential)=0.021; HANSEN integrated essentiality score=0.110; Mtb RBH anchor Rv0546c=non-essential (agree); ProteomeLM contextual percentile=0.654; target-priority score=64.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1337 ML1362 Q49894 mctB ML1362 MLC1351.10c u0247f Copper transporter MctB 317 0.10418 non-essential 0.10993 non-essential high NA high_confidence_nonessential NP_216214.1 73.8 0.03757 44.578 Exploratory ESM-2 calibrated P(essential)=0.104; HANSEN integrated essentiality score=0.110; ProteomeLM contextual percentile=0.038; target-priority score=44.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1338 ML1751 Q9CBP5 ML1751 THIF-type NAD/FAD binding fold domain-containing protein 721 0.03424 non-essential 0.10978 non-essential high NA high_confidence_nonessential NP_215871.1 57.5 0.31997 57.356 Moderate candidate ESM-2 calibrated P(essential)=0.034; HANSEN integrated essentiality score=0.110; ProteomeLM contextual percentile=0.320; target-priority score=57.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1339 ML2297 Q9CB96 ML2297 Hydrolase 324 0.04656 non-essential 0.10924 non-essential high NA high_confidence_nonessential NP_218187.1 80.2 0.26675 55.163 Moderate candidate ESM-2 calibrated P(essential)=0.047; HANSEN integrated essentiality score=0.109; ProteomeLM contextual percentile=0.267; target-priority score=55.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1340 ML0910 O69556 murF ML0910 MLCB268.06c UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase (EC 6.3.2.10) (D-alanyl-D-alanine-adding enzyme) (UDP-MurNAc-pentapeptide synthetase) 517 0.06543 non-essential 0.10922 non-essential high NA high_confidence_nonessential NP_216673.1 75.3 0.14778 66.111 Strong candidate ESM-2 calibrated P(essential)=0.065; HANSEN integrated essentiality score=0.109; ProteomeLM contextual percentile=0.148; target-priority score=66.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1341 ML2440 P54883 senX3 ML2440 B2168_C3_247 Sensor-like histidine kinase SenX3 (EC 2.7.13.3) 443 0.04656 non-essential 0.10908 non-essential high NA high_confidence_nonessential NP_215004.1 84.1 0.25611 58.456 Moderate candidate ESM-2 calibrated P(essential)=0.047; HANSEN integrated essentiality score=0.109; ProteomeLM contextual percentile=0.256; target-priority score=58.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1342 ML2551 Q9CD24 aac ML2551 Aminoglycoside 2'-N-acetyltransferase 182 0.0 non-essential 0.10896 non-essential high NA high_confidence_nonessential NP_214776.1 79.1 0.45899 61.867 Moderate candidate ESM-2 calibrated P(essential)=0.000; HANSEN integrated essentiality score=0.109; ProteomeLM contextual percentile=0.459; target-priority score=61.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1343 ML0041 Q7AQP4 ML0041 Probable secreted protease 446 0.10418 non-essential 0.10882 non-essential high NA high_confidence_nonessential NP_218400.1 79.4 0.02004 48.317 Exploratory ESM-2 calibrated P(essential)=0.104; HANSEN integrated essentiality score=0.109; ProteomeLM contextual percentile=0.020; target-priority score=48.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1344 ML0284 Q7AQK3 ML0284 DUF3151 domain-containing protein 137 0.06981 non-essential 0.1087 non-essential high agree high_confidence_nonessential Rv0360c 85.4 NE 0 0.38635 56.358 Moderate candidate ESM-2 calibrated P(essential)=0.070; HANSEN integrated essentiality score=0.109; Mtb RBH anchor Rv0360c=non-essential (agree); ProteomeLM contextual percentile=0.386; target-priority score=56.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1345 ML2573 O69497 gabD1 ML2573 MLCB1883.11c Succinate-semialdehyde dehydrogenase [NADP(+)] (SSADH) (SSDH) (EC 1.2.1.79) 457 0.02975 non-essential 0.1087 non-essential high NA high_confidence_nonessential NP_216247.2 85.7 0.3087 66.028 Strong candidate ESM-2 calibrated P(essential)=0.030; HANSEN integrated essentiality score=0.109; ProteomeLM contextual percentile=0.309; target-priority score=66.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1346 ML2378 P54881 mmpL4 ML2378 u1740v Probable transport protein MmpL4 959 0.02518 non-essential 0.10865 non-essential high NA high_confidence_nonessential NP_214964.1 76.4 0.35817 56.24 Moderate candidate ESM-2 calibrated P(essential)=0.025; HANSEN integrated essentiality score=0.109; ProteomeLM contextual percentile=0.358; target-priority score=56.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:45Z 1347 ML2237 P49774 ML2237 MLCB5.04c u296a Uncharacterized HIT-like protein ML2237 134 0.02105 non-essential 0.10865 non-essential high agree high_confidence_nonessential Rv0759c 81.8 NE 0 0.6268 66.673 Strong candidate ESM-2 calibrated P(essential)=0.021; HANSEN integrated essentiality score=0.109; Mtb RBH anchor Rv0759c=non-essential (agree); ProteomeLM contextual percentile=0.627; target-priority score=66.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1348 ML2710 Q50205 yidC ML2710 Membrane protein insertase YidC (Foldase YidC) (Membrane integrase YidC) (Membrane protein YidC) 380 0.05767 non-essential 0.10831 non-essential high NA high_confidence_nonessential NP_218438.1 88.1 0.22668 49.589 Exploratory ESM-2 calibrated P(essential)=0.058; HANSEN integrated essentiality score=0.108; ProteomeLM contextual percentile=0.227; target-priority score=49.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1349 ML0269 Q7AQK8 fgd ML0269 F420-dependent glucose-6-phosphate dehydrogenase (FGD) (G6PD) (EC 1.1.98.2) 336 0.07126 non-essential 0.10825 non-essential high NA high_confidence_nonessential NP_214921.1 89.3 0.13651 58.921 Moderate candidate ESM-2 calibrated P(essential)=0.071; HANSEN integrated essentiality score=0.108; ProteomeLM contextual percentile=0.137; target-priority score=58.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1350 ML0729 Q49670 ML0729 B1308_C2_167 u1308r Nucleoside triphosphate pyrophosphatase (EC 3.6.1.9) (Nucleotide pyrophosphatase) (Nucleotide PPase) 213 0.01709 non-essential 0.10814 non-essential high agree high_confidence_nonessential Rv3282 65.7 NE 0 0.60301 75.181 Strong candidate ESM-2 calibrated P(essential)=0.017; HANSEN integrated essentiality score=0.108; Mtb RBH anchor Rv3282=non-essential (agree); ProteomeLM contextual percentile=0.603; target-priority score=75.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1351 ML2322 Q9CB78 asd ML2322 Aspartate-semialdehyde dehydrogenase (ASA dehydrogenase) (ASADH) (EC 1.2.1.11) (Aspartate-beta-semialdehyde dehydrogenase) 351 0.05422 non-essential 0.10782 non-essential high NA high_confidence_nonessential NP_218225.1 84.4 0.19474 64.834 Moderate candidate ESM-2 calibrated P(essential)=0.054; HANSEN integrated essentiality score=0.108; ProteomeLM contextual percentile=0.195; target-priority score=64.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1352 ML1330 P54075 pafC ML1330 B2126_C2_220 MLCB2533.26 Protein PafC 324 0.06253 non-essential 0.10738 non-essential high NA high_confidence_nonessential NP_216611.1 74.2 0.20601 47.17 Exploratory ESM-2 calibrated P(essential)=0.063; HANSEN integrated essentiality score=0.107; ProteomeLM contextual percentile=0.206; target-priority score=47.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1353 ML0427 O07708 orn ML0427 MLCL383.34c Oligoribonuclease (EC 3.1.15.-) 215 0.01648 non-essential 0.10685 non-essential high NA high_confidence_nonessential NP_217027.1 83.7 0.36506 63.862 Moderate candidate ESM-2 calibrated P(essential)=0.016; HANSEN integrated essentiality score=0.107; ProteomeLM contextual percentile=0.365; target-priority score=63.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1354 ML1288 Q9CC46 ML1288 Possible peptidase 467 0.06307 non-essential 0.10677 non-essential high agree high_confidence_nonessential Rv2141c 84.3 NE 0 0.39198 59.465 Moderate candidate ESM-2 calibrated P(essential)=0.063; HANSEN integrated essentiality score=0.107; Mtb RBH anchor Rv2141c=non-essential (agree); ProteomeLM contextual percentile=0.392; target-priority score=59.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1355 ML0004 Q9CDF4 ML0004 MLB1770.04 UPF0232 protein ML0004 189 0.09148 non-essential 0.10673 non-essential high agree high_confidence_nonessential Rv0004 77.2 NE 0 0.27364 48.95 Exploratory ESM-2 calibrated P(essential)=0.091; HANSEN integrated essentiality score=0.107; Mtb RBH anchor Rv0004=non-essential (agree); ProteomeLM contextual percentile=0.274; target-priority score=49.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1356 ML2309 Q9CB84 ML2309 Calcineurin-like phosphoesterase domain-containing protein 330 0.02105 non-essential 0.10596 non-essential high agree high_confidence_nonessential Rv3683 84.9 NE 0 0.60238 66.188 Strong candidate ESM-2 calibrated P(essential)=0.021; HANSEN integrated essentiality score=0.106; Mtb RBH anchor Rv3683=non-essential (agree); ProteomeLM contextual percentile=0.602; target-priority score=66.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1357 ML1553 Q9Z5I7 proS ML1553 MLCB596.17c Proline--tRNA ligase (EC 6.1.1.15) (Prolyl-tRNA synthetase) (ProRS) 480 0.03424 non-essential 0.1058 non-essential high NA high_confidence_nonessential 0.27927 63.23 Moderate candidate ESM-2 calibrated P(essential)=0.034; HANSEN integrated essentiality score=0.106; ProteomeLM contextual percentile=0.279; target-priority score=63.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1358 ML1950 Q7AQ13 ML1950 Carbohydrate degrading enzyme 291 0.08382 non-essential 0.10579 non-essential high NA high_confidence_nonessential NP_215612.1 81.1 0.09455 48.669 Exploratory ESM-2 calibrated P(essential)=0.084; HANSEN integrated essentiality score=0.106; ProteomeLM contextual percentile=0.095; target-priority score=48.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1359 ML2582 Q9CD17 ML2582 Conserved membrane protein 600 0.05764 non-essential 0.10579 non-essential high NA high_confidence_nonessential NP_214740.1 70.1 0.21102 49.908 Exploratory ESM-2 calibrated P(essential)=0.058; HANSEN integrated essentiality score=0.106; ProteomeLM contextual percentile=0.211; target-priority score=49.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1360 ML2070 Q9CBE8 ML2070 VWFA domain-containing protein 733 0.12066 non-essential 0.10573 non-essential high agree high_confidence_nonessential Rv1836c 65.4 NE 0 0.11209 44.248 Exploratory ESM-2 calibrated P(essential)=0.121; HANSEN integrated essentiality score=0.106; Mtb RBH anchor Rv1836c=non-essential (agree); ProteomeLM contextual percentile=0.112; target-priority score=44.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1361 ML2094 Q50098 pstC phoW1 pstC2 ML2094 Phosphate transport system permease protein PstC 319 0.00543 non-essential 0.10567 non-essential high NA high_confidence_nonessential NP_215444.1 79.0 0.42455 58.535 Moderate candidate ESM-2 calibrated P(essential)=0.005; HANSEN integrated essentiality score=0.106; ProteomeLM contextual percentile=0.425; target-priority score=58.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1362 ML1119 Q9CC84 ML1119 Nuclease SbcCD subunit D 383 0.09148 non-essential 0.10562 non-essential high agree high_confidence_nonessential Rv1277 82.0 NE 0 0.24358 52.746 Moderate candidate ESM-2 calibrated P(essential)=0.091; HANSEN integrated essentiality score=0.106; Mtb RBH anchor Rv1277=non-essential (agree); ProteomeLM contextual percentile=0.244; target-priority score=52.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1363 ML0557 Q9CCP6 lprG ML0557 Lipoarabinomannan carrier protein LprG (27 kDa lipoprotein) (Antigen P27) (Lipoprotein LprG) (Triacylglyceride transfer protein LprG) 238 0.02105 non-essential 0.10556 non-essential high NA high_confidence_nonessential NP_215927.1 68.1 0.35441 57.767 Moderate candidate ESM-2 calibrated P(essential)=0.021; HANSEN integrated essentiality score=0.106; ProteomeLM contextual percentile=0.354; target-priority score=57.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1364 ML2620 O06081 mmpL3 ML2620 MLCL622.18c Probable trehalose monomycolate exporter MmpL3 (TMM exporter MmpL3) (MmpL3 transporter) (Mycobacterial membrane protein large 3) 955 0.07497 non-essential 0.1052 non-essential high NA high_confidence_nonessential NP_214720.1 75.4 0.12461 51.084 Moderate candidate ESM-2 calibrated P(essential)=0.075; HANSEN integrated essentiality score=0.105; ProteomeLM contextual percentile=0.125; target-priority score=51.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:45Z 1365 ML2557 Q7APU6 ML2557 Uncharacterized protein 98 0.01648 non-essential 0.10507 non-essential high agree high_confidence_nonessential Rv0250c 73.7 NE 0 0.64433 61.493 Moderate candidate ESM-2 calibrated P(essential)=0.016; HANSEN integrated essentiality score=0.105; Mtb RBH anchor Rv0250c=non-essential (agree); ProteomeLM contextual percentile=0.644; target-priority score=61.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1366 ML1418 Q9CC07 ML1418 Thioredoxin domain-containing protein 182 0.02734 non-essential 0.10487 non-essential high agree high_confidence_nonessential Rv1732c 86.3 NE 0 0.55604 65.723 Strong candidate ESM-2 calibrated P(essential)=0.027; HANSEN integrated essentiality score=0.105; Mtb RBH anchor Rv1732c=non-essential (agree); ProteomeLM contextual percentile=0.556; target-priority score=65.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1367 ML1803 Q9CBM4 ML1803 NfeD-like C-terminal domain-containing protein 143 0.01861 non-essential 0.10485 non-essential high agree high_confidence_nonessential Rv1487 74.8 NE 0 0.6124 64.885 Moderate candidate ESM-2 calibrated P(essential)=0.019; HANSEN integrated essentiality score=0.105; Mtb RBH anchor Rv1487=non-essential (agree); ProteomeLM contextual percentile=0.612; target-priority score=64.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1368 ML0032 Q50192 leuS ML0032 MLB1770.20 MLCB628.03 Leucine--tRNA ligase (EC 6.1.1.4) (Leucyl-tRNA synthetase) (LeuRS) 972 0.05511 non-essential 0.10476 non-essential high NA high_confidence_nonessential NP_214555.1 83.7 0.1841 60.952 Moderate candidate ESM-2 calibrated P(essential)=0.055; HANSEN integrated essentiality score=0.105; ProteomeLM contextual percentile=0.184; target-priority score=61.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:45Z 1369 ML1651 Q9CBS8 aceE ML1651 Pyruvate dehydrogenase E1 component (EC 1.2.4.1) 936 0.09809 non-essential 0.10466 non-essential high NA high_confidence_nonessential NP_216757.3 89.4 0.00877 53.326 Moderate candidate ESM-2 calibrated P(essential)=0.098; HANSEN integrated essentiality score=0.105; ProteomeLM contextual percentile=0.009; target-priority score=53.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:45Z 1370 ML1217 P45487 ML1217 B1170_C2_196 8-amino-7-oxononanoate synthase (AONS) (EC 2.3.1.47) (7-keto-8-amino-pelargonic acid synthase) (7-KAP synthase) (KAPA synthase) (8-amino-7-ketopelargonate synthase) (Alpha-oxoamine synthase) 385 0.04816 non-essential 0.10465 non-essential high NA high_confidence_nonessential YP_177822.1 80.1 0.20288 65.18 Strong candidate ESM-2 calibrated P(essential)=0.048; HANSEN integrated essentiality score=0.105; ProteomeLM contextual percentile=0.203; target-priority score=65.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1371 ML1804 Q9CBM3 ML1804 Uncharacterized protein ML1804 298 0.03604 non-essential 0.10452 non-essential high agree high_confidence_nonessential Rv1486c 76.7 NE 0 0.52724 60.347 Moderate candidate ESM-2 calibrated P(essential)=0.036; HANSEN integrated essentiality score=0.105; Mtb RBH anchor Rv1486c=non-essential (agree); ProteomeLM contextual percentile=0.527; target-priority score=60.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1372 ML0093 Q9CDB7 ML0093 Galactofuranosyltransferase GlfT2 (EC 2.4.1.288) (Arabinogalactan galactosyltransferase 2) (Galactofuranosylgalactofuranosylrhamnosyl-N-acetylglucosaminyl-diphospho-decaprenol beta-1,5/1,6-galactofuranosyltransferase) (Polymerizing galactofuranosyltransferase GlfT2) 643 0.05052 non-essential 0.10447 non-essential high NA high_confidence_nonessential NP_218325.1 85.4 0.1985 62.63 Moderate candidate ESM-2 calibrated P(essential)=0.051; HANSEN integrated essentiality score=0.104; ProteomeLM contextual percentile=0.198; target-priority score=62.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1373 ML2327 Q7APW5 gatD ML2327 Lipid II isoglutaminyl synthase (glutamine-hydrolyzing) subunit GatD (EC 6.3.5.13) (Lipid II isoglutaminyl synthase glutaminase subunit) (EC 3.5.1.2) 230 0.09187 non-essential 0.10423 non-essential high NA high_confidence_nonessential NP_218230.1 86.1 0.01378 60.465 Moderate candidate ESM-2 calibrated P(essential)=0.092; HANSEN integrated essentiality score=0.104; ProteomeLM contextual percentile=0.014; target-priority score=60.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1374 ML1770 Q9CBN6 uspC ML1770 Sugar transport periplasmic binding protein 446 0.03424 non-essential 0.10411 non-essential high NA high_confidence_nonessential NP_216834.1 73.5 0.29493 54.541 Moderate candidate ESM-2 calibrated P(essential)=0.034; HANSEN integrated essentiality score=0.104; ProteomeLM contextual percentile=0.295; target-priority score=54.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1375 ML1406 Q9CC15 argC ML1406 N-acetyl-gamma-glutamyl-phosphate reductase (AGPR) (EC 1.2.1.38) (N-acetyl-glutamate semialdehyde dehydrogenase) (NAGSA dehydrogenase) 347 0.06439 non-essential 0.10397 non-essential high NA high_confidence_nonessential NP_216168.1 81.1 0.1315 62.78 Moderate candidate ESM-2 calibrated P(essential)=0.064; HANSEN integrated essentiality score=0.104; ProteomeLM contextual percentile=0.131; target-priority score=62.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1376 ML1299 Q7AQ75 ML1299 DUF3090 domain-containing protein 196 0.03861 non-essential 0.10394 non-essential high agree high_confidence_nonessential Rv2134c 91.1 NE 0 0.51033 59.468 Moderate candidate ESM-2 calibrated P(essential)=0.039; HANSEN integrated essentiality score=0.104; Mtb RBH anchor Rv2134c=non-essential (agree); ProteomeLM contextual percentile=0.510; target-priority score=59.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1377 ML1090 Q9CCA0 corA ML1090 Magnesium transport protein CorA 369 0.02518 non-essential 0.10393 non-essential high NA high_confidence_nonessential NP_215755.1 79.4 0.32812 57.032 Moderate candidate ESM-2 calibrated P(essential)=0.025; HANSEN integrated essentiality score=0.104; ProteomeLM contextual percentile=0.328; target-priority score=57.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1378 ML2188 Q50047 phoU1 phoY phoY1 ML2188 Phosphate-specific transport system accessory protein PhoU homolog 1 (Pst system accessory protein PhoU homolog 1) 222 0.03925 non-essential 0.10353 non-essential high NA high_confidence_nonessential NP_215336.1 93.0 0.27113 53.657 Moderate candidate ESM-2 calibrated P(essential)=0.039; HANSEN integrated essentiality score=0.104; ProteomeLM contextual percentile=0.271; target-priority score=53.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1379 ML1298 Q9CC41 ML1298 Phosphoglycerate mutase 250 0.06195 non-essential 0.10347 non-essential high agree high_confidence_nonessential Rv2135c 75.2 NE 0 0.37946 56.706 Moderate candidate ESM-2 calibrated P(essential)=0.062; HANSEN integrated essentiality score=0.103; Mtb RBH anchor Rv2135c=non-essential (agree); ProteomeLM contextual percentile=0.379; target-priority score=56.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1380 ML0891 Q7AQD8 ML0891 Uncharacterized protein 130 0.00674 non-essential 0.10328 non-essential high agree high_confidence_nonessential Rv2183c 62.6 NE 0 0.68128 62.208 Moderate candidate ESM-2 calibrated P(essential)=0.007; HANSEN integrated essentiality score=0.103; Mtb RBH anchor Rv2183c=non-essential (agree); ProteomeLM contextual percentile=0.681; target-priority score=62.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1381 ML1103 Q9CC92 ML1103 Possible oxidoreductase subunit 453 0.09526 non-essential 0.10307 non-essential high NA high_confidence_nonessential NP_215773.1 85.8 0.03068 47.096 Exploratory ESM-2 calibrated P(essential)=0.095; HANSEN integrated essentiality score=0.103; ProteomeLM contextual percentile=0.031; target-priority score=47.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1382 ML2424 Q49823 ML2424 B2168_F1_26 Putative hydrolase ML2424 (EC 3.1.-.-) 300 0.06412 non-essential 0.10306 non-essential high NA high_confidence_nonessential YP_177732.1 83.0 0.15091 54.774 Moderate candidate ESM-2 calibrated P(essential)=0.064; HANSEN integrated essentiality score=0.103; ProteomeLM contextual percentile=0.151; target-priority score=54.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1383 ML0190 Q9CD62 ML0190 Fe2OG dioxygenase domain-containing protein 205 0.01861 non-essential 0.10305 non-essential high agree high_confidence_nonessential Rv1000c 81.4 NE 0 0.59487 64.794 Moderate candidate ESM-2 calibrated P(essential)=0.019; HANSEN integrated essentiality score=0.103; Mtb RBH anchor Rv1000c=non-essential (agree); ProteomeLM contextual percentile=0.595; target-priority score=64.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1384 ML1639 O69481 ML1639 MLCB1243.36 GTP cyclohydrolase 1 type 2 homolog 385 0.03424 non-essential 0.10292 non-essential high NA high_confidence_nonessential NP_216746.1 79.5 0.27865 57.686 Moderate candidate ESM-2 calibrated P(essential)=0.034; HANSEN integrated essentiality score=0.103; ProteomeLM contextual percentile=0.279; target-priority score=57.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1385 ML2193 Q9CBC9 mshD ML2193 Mycothiol acetyltransferase (MSH acetyltransferase) (EC 2.3.1.189) (Mycothiol synthase) 311 0.07502 non-essential 0.10279 non-essential high NA high_confidence_nonessential NP_215334.1 75.2 0.0933 56.827 Moderate candidate ESM-2 calibrated P(essential)=0.075; HANSEN integrated essentiality score=0.103; ProteomeLM contextual percentile=0.093; target-priority score=56.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1386 ML1293 P46727 pyrD ML1293 B2126_F3_143 Dihydroorotate dehydrogenase (quinone) (EC 1.3.5.2) (DHOdehase) (DHOD) (DHODase) (Dihydroorotate oxidase) 356 0.06042 non-essential 0.10267 non-essential high NA high_confidence_nonessential NP_216655.1 80.9 0.14402 62.113 Moderate candidate ESM-2 calibrated P(essential)=0.060; HANSEN integrated essentiality score=0.103; ProteomeLM contextual percentile=0.144; target-priority score=62.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1387 ML1954 Q9X795 coaA ML1954 MLCB1222.23 Pantothenate kinase (EC 2.7.1.33) (Pantothenic acid kinase) 312 0.03769 non-essential 0.10266 non-essential high NA high_confidence_nonessential NP_215608.1 93.6 0.23669 66.055 Strong candidate ESM-2 calibrated P(essential)=0.038; HANSEN integrated essentiality score=0.103; ProteomeLM contextual percentile=0.237; target-priority score=66.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1388 ML0624 Q9CCN2 hrcA ML0624 B1937_F1_18/B1937_F3_95 Heat-inducible transcription repressor HrcA 343 0.09148 non-essential 0.10264 non-essential high NA high_confidence_nonessential NP_216890.1 89.8 0.04822 46.177 Exploratory ESM-2 calibrated P(essential)=0.091; HANSEN integrated essentiality score=0.103; ProteomeLM contextual percentile=0.048; target-priority score=46.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1389 ML0129 Q9CD87 ML0129 Trans-acting enoyl reductase (EC 1.3.1.-) 418 0.06074 non-essential 0.10261 non-essential high NA high_confidence_nonessential NP_217469.1 86.6 0.16406 54.674 Moderate candidate ESM-2 calibrated P(essential)=0.061; HANSEN integrated essentiality score=0.103; ProteomeLM contextual percentile=0.164; target-priority score=54.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1390 ML1831 Q7AQ22 mapA map ML1831 Methionine aminopeptidase (MAP) (MetAP) (EC 3.4.11.18) (Peptidase M) 266 0.03769 non-essential 0.10252 non-essential high NA high_confidence_nonessential YP_177748.1 83.4 0.24546 62.782 Moderate candidate ESM-2 calibrated P(essential)=0.038; HANSEN integrated essentiality score=0.103; ProteomeLM contextual percentile=0.245; target-priority score=62.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1391 ML2564 Q7APU3 fadA2 ML2564 Acetyl-CoA C-acetyltransferase 457 0.03604 non-essential 0.10249 non-essential high NA high_confidence_nonessential NP_214757.1 88.0 0.27552 55.081 Moderate candidate ESM-2 calibrated P(essential)=0.036; HANSEN integrated essentiality score=0.102; ProteomeLM contextual percentile=0.276; target-priority score=55.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1392 ML0516 Q9CCS6 aroC aroF ML0516 Chorismate synthase (CS) (EC 4.2.3.5) (5-enolpyruvylshikimate-3-phosphate phospholyase) 407 0.04192 non-essential 0.10218 non-essential high NA high_confidence_nonessential NP_217056.1 88.3 0.21603 65.513 Strong candidate ESM-2 calibrated P(essential)=0.042; HANSEN integrated essentiality score=0.102; ProteomeLM contextual percentile=0.216; target-priority score=65.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1393 ML0569 Q7AQI6 ML0569 Membrane protein 271 0.01648 non-essential 0.10198 non-essential high agree high_confidence_nonessential Rv1433 68.3 NE 0 0.56293 71.59 Strong candidate ESM-2 calibrated P(essential)=0.016; HANSEN integrated essentiality score=0.102; Mtb RBH anchor Rv1433=non-essential (agree); ProteomeLM contextual percentile=0.563; target-priority score=71.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1394 ML1397 Q9CC19 tsnR ML1397 rRNA methyltransferase 259 0.02538 non-essential 0.10195 non-essential high NA high_confidence_nonessential NP_216160.1 73.2 0.31559 56.999 Moderate candidate ESM-2 calibrated P(essential)=0.025; HANSEN integrated essentiality score=0.102; ProteomeLM contextual percentile=0.316; target-priority score=57.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1395 ML1839 Q7AQ20 sppA ML1839 Protease IV, signal peptide peptidase 602 0.06199 non-essential 0.10192 non-essential high NA high_confidence_nonessential NP_215238.1 80.4 0.16093 52.423 Moderate candidate ESM-2 calibrated P(essential)=0.062; HANSEN integrated essentiality score=0.102; ProteomeLM contextual percentile=0.161; target-priority score=52.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1396 ML1276 Q9CC50 ML1276 Conserved membrane protein 146 0.01709 non-essential 0.10187 non-essential high agree high_confidence_nonessential Rv1616 66.7 NE 0 0.60113 63.018 Moderate candidate ESM-2 calibrated P(essential)=0.017; HANSEN integrated essentiality score=0.102; Mtb RBH anchor Rv1616=non-essential (agree); ProteomeLM contextual percentile=0.601; target-priority score=63.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1397 ML0333 Q9CCW2 pxpA ML0333 5-oxoprolinase subunit A (5-OPase subunit A) (EC 3.5.2.9) (5-oxoprolinase (ATP-hydrolyzing) subunit A) 252 0.04897 non-essential 0.10183 non-essential high NA high_confidence_nonessential 0.20163 58.712 Moderate candidate ESM-2 calibrated P(essential)=0.049; HANSEN integrated essentiality score=0.102; ProteomeLM contextual percentile=0.202; target-priority score=58.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1398 ML1439 Q9CC05 rbpA ML1439 RNA polymerase-binding protein RbpA 111 0.08554 non-essential 0.10177 non-essential high NA high_confidence_nonessential NP_216566.1 97.3 0.07076 46.037 Exploratory ESM-2 calibrated P(essential)=0.086; HANSEN integrated essentiality score=0.102; ProteomeLM contextual percentile=0.071; target-priority score=46.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1399 ML2274 Q9CBA7 ML2274 Secreted protein 112 0.04656 non-essential 0.10177 non-essential high agree high_confidence_nonessential Rv0559c 69.6 NE 0 0.45523 56.625 Moderate candidate ESM-2 calibrated P(essential)=0.047; HANSEN integrated essentiality score=0.102; Mtb RBH anchor Rv0559c=non-essential (agree); ProteomeLM contextual percentile=0.455; target-priority score=56.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1400 ML2411 Q7APV0 ML2411 Possible cytochrome C-type biogenesis protein 262 0.03731 non-essential 0.10174 non-essential high NA high_confidence_nonessential YP_177735.1 78.6 0.28115 49.684 Exploratory ESM-2 calibrated P(essential)=0.037; HANSEN integrated essentiality score=0.102; ProteomeLM contextual percentile=0.281; target-priority score=49.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1401 ML1734 Q9CBQ0 nrdE ML1734 Ribonucleoside-diphosphate reductase subunit alpha (EC 1.17.4.1) (Ribonucleotide reductase R1 subunit) 721 0.08894 non-essential 0.10162 non-essential high NA high_confidence_nonessential NP_217567.1 93.2 0.02818 54.916 Moderate candidate ESM-2 calibrated P(essential)=0.089; HANSEN integrated essentiality score=0.102; ProteomeLM contextual percentile=0.028; target-priority score=54.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1402 ML0512 Q9CCT0 alaS ML0512 Alanine--tRNA ligase (EC 6.1.1.7) (Alanyl-tRNA synthetase) (AlaRS) 908 0.09148 non-essential 0.1016 non-essential high NA high_confidence_nonessential NP_217071.1 84.8 0.01753 54.523 Moderate candidate ESM-2 calibrated P(essential)=0.091; HANSEN integrated essentiality score=0.102; ProteomeLM contextual percentile=0.018; target-priority score=54.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:45Z 1403 ML0487 P38387 secD ML0487 B1177_C1_164 MLCB1259.05 Protein translocase subunit SecD 571 0.09928 non-essential 0.10158 non-essential high NA high_confidence_nonessential NP_217103.1 78.2 0.01628 42.751 Exploratory ESM-2 calibrated P(essential)=0.099; HANSEN integrated essentiality score=0.102; ProteomeLM contextual percentile=0.016; target-priority score=42.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1404 ML0978 Q7AQC1 ML0978 Acetyltransferase 180 0.09928 non-essential 0.10144 non-essential high NA high_confidence_nonessential NP_217263.1 86.2 0.00751 45.461 Exploratory ESM-2 calibrated P(essential)=0.099; HANSEN integrated essentiality score=0.101; ProteomeLM contextual percentile=0.008; target-priority score=45.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1405 ML1675 Q9CBS3 ung ML1675 Uracil-DNA glycosylase (UDG) (EC 3.2.2.27) 227 0.00198 non-essential 0.10134 non-essential high NA high_confidence_nonessential NP_217492.1 88.5 0.38823 67.595 Strong candidate ESM-2 calibrated P(essential)=0.002; HANSEN integrated essentiality score=0.101; ProteomeLM contextual percentile=0.388; target-priority score=67.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1406 ML1678 Q9CBS0 ddl ddlA ML1678 D-alanine--D-alanine ligase (EC 6.3.2.4) (D-Ala-D-Ala ligase) (D-alanylalanine synthetase) 384 0.04041 non-essential 0.10111 non-essential high NA high_confidence_nonessential NP_217497.1 81.7 0.21353 66.567 Strong candidate ESM-2 calibrated P(essential)=0.040; HANSEN integrated essentiality score=0.101; ProteomeLM contextual percentile=0.214; target-priority score=66.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1407 ML2306 Q9CB87 ML2306 Probable anion transporter protein 381 0.09148 non-essential 0.10022 non-essential high NA high_confidence_nonessential NP_218197.1 87.7 0.03694 45.174 Exploratory ESM-2 calibrated P(essential)=0.091; HANSEN integrated essentiality score=0.100; ProteomeLM contextual percentile=0.037; target-priority score=45.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1408 ML1159 Q9CC76 ML1159 Thioredoxin domain-containing protein 301 0.02734 non-essential 0.1002 non-essential high NA high_confidence_nonessential NP_215840.1 67.8 0.30683 53.421 Moderate candidate ESM-2 calibrated P(essential)=0.027; HANSEN integrated essentiality score=0.100; ProteomeLM contextual percentile=0.307; target-priority score=53.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1409 ML0890 Q7AQD9 ML0890 Possible membrane transport ATPase 415 0.04897 non-essential 0.10016 non-essential high agree high_confidence_nonessential Rv2184c 79.4 NE 0 0.41766 58.015 Moderate candidate ESM-2 calibrated P(essential)=0.049; HANSEN integrated essentiality score=0.100; Mtb RBH anchor Rv2184c=non-essential (agree); ProteomeLM contextual percentile=0.418; target-priority score=58.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1410 ML1548 Q7AQ44 ML1548 Calcineurin-like phosphoesterase domain-containing protein 321 0.03604 non-essential 0.10007 non-essential high agree high_confidence_nonessential Rv2795c 88.2 NE 0 0.47214 62.476 Moderate candidate ESM-2 calibrated P(essential)=0.036; HANSEN integrated essentiality score=0.100; Mtb RBH anchor Rv2795c=non-essential (agree); ProteomeLM contextual percentile=0.472; target-priority score=62.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1411 ML2400 Q9CB64 ML2400 Probable transmembrane protein 285 0.04554 non-essential 0.09994 non-essential high NA high_confidence_nonessential NP_215588.1 77.9 0.23294 49.654 Exploratory ESM-2 calibrated P(essential)=0.046; HANSEN integrated essentiality score=0.100; ProteomeLM contextual percentile=0.233; target-priority score=49.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1412 ML0242 Q9CD51 ispE ML0242 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase (CMK) (EC 2.7.1.148) (4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase) 323 0.02518 non-essential 0.09989 non-essential high NA high_confidence_nonessential NP_215527.1 83.2 0.27426 67.263 Strong candidate ESM-2 calibrated P(essential)=0.025; HANSEN integrated essentiality score=0.100; ProteomeLM contextual percentile=0.274; target-priority score=67.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1413 ML1190 Q7AQ86 ML1190 Rv2525c-like glycoside hydrolase-like domain-containing protein 239 0.04041 non-essential 0.09925 non-essential high agree high_confidence_nonessential Rv2525c 82.2 NE 0 0.5 ESM-2 calibrated P(essential)=0.040; HANSEN integrated essentiality score=0.099; Mtb RBH anchor Rv2525c=non-essential (agree); ProteomeLM contextual percentile=0.500 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1414 ML1220 P46715 bioB ML1220 B1170_C3_228 Biotin synthase (EC 2.8.1.6) 345 0.06307 non-essential 0.09913 non-essential high NA high_confidence_nonessential NP_216105.1 87.1 0.11271 61.545 Moderate candidate ESM-2 calibrated P(essential)=0.063; HANSEN integrated essentiality score=0.099; ProteomeLM contextual percentile=0.113; target-priority score=61.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1415 ML0382 Q49871 whiB3 whiB ML0382 Transcriptional regulator WhiB 102 0.06116 non-essential 0.09887 non-essential high NA high_confidence_nonessential NP_217933.1 86.3 0.1459 52.717 Moderate candidate ESM-2 calibrated P(essential)=0.061; HANSEN integrated essentiality score=0.099; ProteomeLM contextual percentile=0.146; target-priority score=52.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1416 ML1121 Q9CC82 ML1121 Probable extracellular solute-binding dependent transport lipoprotein 557 0.03769 non-essential 0.09875 non-essential high NA high_confidence_nonessential NP_215796.1 80.3 0.25172 53.125 Moderate candidate ESM-2 calibrated P(essential)=0.038; HANSEN integrated essentiality score=0.099; ProteomeLM contextual percentile=0.252; target-priority score=53.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1417 ML0181 Q7AQM9 ML0181 5-formyltetrahydrofolate cyclo-ligase (EC 6.3.3.2) 197 0.02105 non-essential 0.09875 non-essential high agree high_confidence_nonessential Rv0992c 72.6 NE 0 0.50094 72.05 Strong candidate ESM-2 calibrated P(essential)=0.021; HANSEN integrated essentiality score=0.099; Mtb RBH anchor Rv0992c=non-essential (agree); ProteomeLM contextual percentile=0.501; target-priority score=72.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1418 ML1260 Q9X7C0 hisH ML1260 MLCB1610.23 Imidazole glycerol phosphate synthase subunit HisH (EC 4.3.2.10) (IGP synthase glutaminase subunit) (EC 3.5.1.2) (IGP synthase subunit HisH) (ImGP synthase subunit HisH) (IGPS subunit HisH) 206 0.04552 non-essential 0.0972 non-essential high NA high_confidence_nonessential NP_216118.1 79.1 0.17595 63.563 Moderate candidate ESM-2 calibrated P(essential)=0.046; HANSEN integrated essentiality score=0.097; ProteomeLM contextual percentile=0.176; target-priority score=63.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1419 ML2550 Q9CD25 ML2550 Carboxyltransferase domain-containing protein 305 0.03604 non-essential 0.09711 non-essential high agree high_confidence_nonessential Rv0263c 78.3 NE 0 0.44834 61.309 Moderate candidate ESM-2 calibrated P(essential)=0.036; HANSEN integrated essentiality score=0.097; Mtb RBH anchor Rv0263c=non-essential (agree); ProteomeLM contextual percentile=0.448; target-priority score=61.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1420 ML0737 P46703 fadE25 acd ML0737 B1308_F1_34 Probable acyl-CoA dehydrogenase fadE25 (EC 1.3.99.-) 389 0.05422 non-essential 0.09657 non-essential high NA high_confidence_nonessential NP_217791.1 92.0 0.15153 57.032 Moderate candidate ESM-2 calibrated P(essential)=0.054; HANSEN integrated essentiality score=0.097; ProteomeLM contextual percentile=0.152; target-priority score=57.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1421 ML0249 Q9CD44 glmU ML0249 Bifunctional protein GlmU [Includes: UDP-N-acetylglucosamine pyrophosphorylase (EC 2.7.7.23) (N-acetylglucosamine-1-phosphate uridyltransferase); Glucosamine-1-phosphate N-acetyltransferase (EC 2.3.1.157)] 492 0.056 non-essential 0.09612 non-essential high NA high_confidence_nonessential NP_215534.1 83.9 0.12273 63.162 Moderate candidate ESM-2 calibrated P(essential)=0.056; HANSEN integrated essentiality score=0.096; ProteomeLM contextual percentile=0.123; target-priority score=63.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1422 ML0099 Q9CDB3 ML0099 Cutinase 336 0.04897 non-essential 0.09608 non-essential high NA high_confidence_nonessential NP_218319.1 73.4 0.18848 51.674 Moderate candidate ESM-2 calibrated P(essential)=0.049; HANSEN integrated essentiality score=0.096; ProteomeLM contextual percentile=0.188; target-priority score=51.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1423 ML1193 Q7AQ84 ML1193 Peptidase M20 dimerisation domain-containing protein 442 0.03424 non-essential 0.09554 non-essential high agree high_confidence_nonessential Rv2522c 86.4 NE 0 0.5 ESM-2 calibrated P(essential)=0.034; HANSEN integrated essentiality score=0.096; Mtb RBH anchor Rv2522c=non-essential (agree); ProteomeLM contextual percentile=0.500 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1424 ML0882 O69582 ctaE ML0882 Probable cytochrome c oxidase subunit 3 (EC 7.1.1.9) (Cytochrome aa3 subunit 3) (Cytochrome c oxidase polypeptide III) 202 0.05755 non-essential 0.09502 non-essential high NA high_confidence_nonessential NP_216709.1 90.6 0.13275 55.137 Moderate candidate ESM-2 calibrated P(essential)=0.058; HANSEN integrated essentiality score=0.095; ProteomeLM contextual percentile=0.133; target-priority score=55.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1425 ML0887 Q9CCE6 ML0887 Acyl-CoA synthetase 600 0.06543 non-essential 0.09459 non-essential high NA high_confidence_nonessential NP_216703.1 80.5 0.11021 49.624 Exploratory ESM-2 calibrated P(essential)=0.065; HANSEN integrated essentiality score=0.095; ProteomeLM contextual percentile=0.110; target-priority score=49.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1426 ML2143 O33057 ML2143 MLCB57.28c Uncharacterized protein ML2143 579 0.03769 non-essential 0.09459 non-essential high NA high_confidence_nonessential NP_215391.1 75.7 0.23607 50.125 Moderate candidate ESM-2 calibrated P(essential)=0.038; HANSEN integrated essentiality score=0.095; ProteomeLM contextual percentile=0.236; target-priority score=50.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1427 ML1676 Q9CBS2 thiL ML1676 Thiamine-monophosphate kinase (TMP kinase) (Thiamine-phosphate kinase) (EC 2.7.4.16) 325 0.02644 non-essential 0.09432 non-essential high NA high_confidence_nonessential NP_217493.1 80.9 0.2392 66.061 Strong candidate ESM-2 calibrated P(essential)=0.026; HANSEN integrated essentiality score=0.094; ProteomeLM contextual percentile=0.239; target-priority score=66.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1428 ML0320 Q9CCW7 ML0320 Transcription factor 165 0.06716 non-essential 0.09431 non-essential high NA high_confidence_nonessential NP_218100.1 97.5 0.10457 48.308 Exploratory ESM-2 calibrated P(essential)=0.067; HANSEN integrated essentiality score=0.094; ProteomeLM contextual percentile=0.105; target-priority score=48.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1429 ML2434 P54882 ML2434 B2168_C2_208 Exopolyphosphatase 1 (ExopolyPase 1) (EC 3.6.1.11) 339 0.09148 non-essential 0.09423 non-essential high agree high_confidence_nonessential Rv0496 85.6 NE 0 0.11772 55.128 Moderate candidate ESM-2 calibrated P(essential)=0.091; HANSEN integrated essentiality score=0.094; Mtb RBH anchor Rv0496=non-essential (agree); ProteomeLM contextual percentile=0.118; target-priority score=55.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1430 ML2380 Q9CB68 ML2380 Possible secreted protein 153 0.03604 non-essential 0.09392 non-essential high agree high_confidence_nonessential Rv0455c 66.4 NE 0 0.43644 57.311 Moderate candidate ESM-2 calibrated P(essential)=0.036; HANSEN integrated essentiality score=0.094; Mtb RBH anchor Rv0455c=non-essential (agree); ProteomeLM contextual percentile=0.436; target-priority score=57.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1431 ML1149 P53523 ML1149 u471a Corrinoid adenosyltransferase (EC 2.5.1.17) (Cob(II)alamin adenosyltransferase) (Cob(II)yrinic acid a,c-diamide adenosyltransferase) (Cobinamide/cobalamin adenosyltransferase) 191 0.02105 non-essential 0.09391 non-essential high NA high_confidence_nonessential NP_215830.1 81.2 0.25986 66.619 Strong candidate ESM-2 calibrated P(essential)=0.021; HANSEN integrated essentiality score=0.094; ProteomeLM contextual percentile=0.260; target-priority score=66.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1432 ML0068 Q9CDD0 ML0068 Uncharacterized protein 238 0.09148 non-essential 0.09365 non-essential high agree high_confidence_nonessential Rv3850 74.2 NE 0 0.15967 45.581 Exploratory ESM-2 calibrated P(essential)=0.091; HANSEN integrated essentiality score=0.094; Mtb RBH anchor Rv3850=non-essential (agree); ProteomeLM contextual percentile=0.160; target-priority score=45.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1433 ML0377 Q49864 tsaE ML0377 B229_C2_205 u229f tRNA threonylcarbamoyladenosine biosynthesis protein TsaE (t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaE) 161 0.01761 non-essential 0.09334 non-essential high NA high_confidence_nonessential NP_217939.1 77.4 0.30182 56.607 Moderate candidate ESM-2 calibrated P(essential)=0.018; HANSEN integrated essentiality score=0.093; ProteomeLM contextual percentile=0.302; target-priority score=56.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1434 ML0866 O32954 ilvE ML0866 MLCB22.12c Probable branched-chain-amino-acid aminotransferase (BCAT) (EC 2.6.1.42) 368 0.01079 non-essential 0.09318 non-essential high NA high_confidence_nonessential NP_216726.1 87.2 0.3062 65.418 Strong candidate ESM-2 calibrated P(essential)=0.011; HANSEN integrated essentiality score=0.093; ProteomeLM contextual percentile=0.306; target-priority score=65.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1435 ML1698 Q7AQ27 ML1698 Conserved membrane protein 277 0.01172 non-essential 0.09316 non-essential high agree high_confidence_nonessential Rv3005c 68.7 NE 0 0.56043 60.173 Moderate candidate ESM-2 calibrated P(essential)=0.012; HANSEN integrated essentiality score=0.093; Mtb RBH anchor Rv3005c=non-essential (agree); ProteomeLM contextual percentile=0.560; target-priority score=60.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1436 ML2592 Q9CD11 mce1D ML2592 Secreted protein 531 0.04324 non-essential 0.09307 non-essential high NA high_confidence_nonessential NP_214686.1 75.1 0.20914 47.565 Exploratory ESM-2 calibrated P(essential)=0.043; HANSEN integrated essentiality score=0.093; ProteomeLM contextual percentile=0.209; target-priority score=47.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1437 ML2042 Q9CBF5 ahpC ML2042 Alkyl hydroperoxide reductase C (EC 1.11.1.28) (Peroxiredoxin) (Thioredoxin peroxidase) 195 0.02734 non-essential 0.09295 non-essential high NA high_confidence_nonessential NP_216944.1 86.7 0.23857 62.138 Moderate candidate ESM-2 calibrated P(essential)=0.027; HANSEN integrated essentiality score=0.093; ProteomeLM contextual percentile=0.239; target-priority score=62.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1438 ML2038 P43315 bfr bfrA ML2038 Bacterioferritin (BFR) (EC 1.16.3.1) (Major membrane protein II) (MMP-II) 159 0.00674 non-essential 0.09294 non-essential high NA high_confidence_nonessential NP_216392.1 90.6 0.32373 65.285 Strong candidate ESM-2 calibrated P(essential)=0.007; HANSEN integrated essentiality score=0.093; ProteomeLM contextual percentile=0.324; target-priority score=65.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1439 ML2588 Q9CD15 yrbE1B ML2588 Conserved membrane protein 289 0.00543 non-essential 0.09273 non-essential high NA high_confidence_nonessential NP_214682.1 84.8 0.35629 55.844 Moderate candidate ESM-2 calibrated P(essential)=0.005; HANSEN integrated essentiality score=0.093; ProteomeLM contextual percentile=0.356; target-priority score=55.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1440 ML1659 O69469 rnc ML1659 MLCB1243.15 Ribonuclease 3 (EC 3.1.26.3) (Ribonuclease III) (RNase III) 238 0.06543 non-essential 0.09255 non-essential high NA high_confidence_nonessential NP_217441.1 85.8 0.08015 55.771 Moderate candidate ESM-2 calibrated P(essential)=0.065; HANSEN integrated essentiality score=0.093; ProteomeLM contextual percentile=0.080; target-priority score=55.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1441 ML0279 Q7AQK5 ML0279 Acyl-coenzyme A thioesterase THEM4 (EC 3.1.2.2) (Thioesterase superfamily member 4) 218 0.02734 non-essential 0.09247 non-essential high agree high_confidence_nonessential Rv0356c 73.4 NE 0 0.43081 65.966 Strong candidate ESM-2 calibrated P(essential)=0.027; HANSEN integrated essentiality score=0.092; Mtb RBH anchor Rv0356c=non-essential (agree); ProteomeLM contextual percentile=0.431; target-priority score=66.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1442 ML0555 Q9CCP8 ribG ML0555 Riboflavin biosynthesis protein RibD [Includes: Diaminohydroxyphosphoribosylaminopyrimidine deaminase (DRAP deaminase) (EC 3.5.4.26) (Riboflavin-specific deaminase); 5-amino-6-(5-phosphoribosylamino)uracil reductase (EC 1.1.1.193) (HTP reductase)] 339 0.05949 non-essential 0.09242 non-essential high NA high_confidence_nonessential NP_215925.1 78.5 0.08829 62.013 Moderate candidate ESM-2 calibrated P(essential)=0.059; HANSEN integrated essentiality score=0.092; ProteomeLM contextual percentile=0.088; target-priority score=62.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1443 ML2331 Q9CB75 ML2331 Possible secreted protein 256 0.01709 non-essential 0.09238 non-essential high agree high_confidence_nonessential Rv3717 82.0 NE 0 0.50344 63.564 Moderate candidate ESM-2 calibrated P(essential)=0.017; HANSEN integrated essentiality score=0.092; Mtb RBH anchor Rv3717=non-essential (agree); ProteomeLM contextual percentile=0.503; target-priority score=63.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1444 ML0202 Q7AQM2 ML0202 DNA polymerase III subunit delta' (EC 2.7.7.7) 405 0.06636 non-essential 0.09235 non-essential high NA high_confidence_nonessential NP_218161.1 84.4 0.07702 54.996 Moderate candidate ESM-2 calibrated P(essential)=0.066; HANSEN integrated essentiality score=0.092; ProteomeLM contextual percentile=0.077; target-priority score=55.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1445 ML2691 Q9CCY3 ML2691 Transcription regulator PadR N-terminal domain-containing protein 180 0.04472 non-essential 0.09232 non-essential high agree high_confidence_nonessential Rv0047c 89.4 NE 0 0.37383 56.206 Moderate candidate ESM-2 calibrated P(essential)=0.045; HANSEN integrated essentiality score=0.092; Mtb RBH anchor Rv0047c=non-essential (agree); ProteomeLM contextual percentile=0.374; target-priority score=56.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1446 ML1940 Q9X783 xseA ML1940 MLCB1222.08 Exodeoxyribonuclease 7 large subunit (EC 3.1.11.6) (Exodeoxyribonuclease VII large subunit) (Exonuclease VII large subunit) 428 0.07767 non-essential 0.09206 non-essential high NA high_confidence_nonessential NP_215624.1 81.2 0.03444 51.232 Moderate candidate ESM-2 calibrated P(essential)=0.078; HANSEN integrated essentiality score=0.092; ProteomeLM contextual percentile=0.034; target-priority score=51.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1447 ML1017 Q7AQB2 ML1017 Possible conserved integral membrane protein 330 0.01233 non-essential 0.09206 non-essential high agree high_confidence_nonessential Rv2707 75.4 GA 0 0.54352 60.619 Moderate candidate ESM-2 calibrated P(essential)=0.012; HANSEN integrated essentiality score=0.092; Mtb RBH anchor Rv2707=non-essential (agree); ProteomeLM contextual percentile=0.544; target-priority score=60.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1448 ML0501 P36429 aspS ML0501 MLCB1259.19 Aspartate--tRNA(Asp/Asn) ligase (EC 6.1.1.23) (Aspartyl-tRNA synthetase) (AspRS) (Non-discriminating aspartyl-tRNA synthetase) (ND-AspRS) 589 0.05587 non-essential 0.09182 non-essential high NA high_confidence_nonessential NP_217088.1 87.8 0.10895 59.431 Moderate candidate ESM-2 calibrated P(essential)=0.056; HANSEN integrated essentiality score=0.092; ProteomeLM contextual percentile=0.109; target-priority score=59.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1449 ML1030 Q7AQA6 ML1030 AB hydrolase-1 domain-containing protein 232 0.03424 non-essential 0.0917 non-essential high agree high_confidence_nonessential Rv2695 77.0 NE 0 0.41578 59.15 Moderate candidate ESM-2 calibrated P(essential)=0.034; HANSEN integrated essentiality score=0.092; Mtb RBH anchor Rv2695=non-essential (agree); ProteomeLM contextual percentile=0.416; target-priority score=59.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1450 ML1200 Q7AQ83 ML1200 Pseudouridine synthase (EC 5.4.99.-) 308 0.07126 non-essential 0.09152 non-essential high NA high_confidence_nonessential NP_216056.1 89.3 0.04947 55.062 Moderate candidate ESM-2 calibrated P(essential)=0.071; HANSEN integrated essentiality score=0.092; ProteomeLM contextual percentile=0.049; target-priority score=55.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1451 ML0258 Q7AQL0 ML0258 Exopolyphosphatase 2 (EC 3.6.1.11) 317 0.09148 non-essential 0.09137 non-essential high agree high_confidence_nonessential Rv1026 77.3 NE 0 0.09267 54.417 Moderate candidate ESM-2 calibrated P(essential)=0.091; HANSEN integrated essentiality score=0.091; Mtb RBH anchor Rv1026=non-essential (agree); ProteomeLM contextual percentile=0.093; target-priority score=54.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1452 ML1399 Q9CC18 ML1399 Guanylate cyclase domain-containing protein 324 0.06716 non-essential 0.09137 non-essential high NA high_confidence_nonessential NP_216163.1 74.4 0.09706 44.975 Exploratory ESM-2 calibrated P(essential)=0.067; HANSEN integrated essentiality score=0.091; ProteomeLM contextual percentile=0.097; target-priority score=45.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1453 ML0764 Q9CCJ6 ML0764 TobH protein 365 0.07935 non-essential 0.09127 non-essential high agree high_confidence_nonessential Rv3256c 75.6 NE 0 0.18535 50.252 Moderate candidate ESM-2 calibrated P(essential)=0.079; HANSEN integrated essentiality score=0.091; Mtb RBH anchor Rv3256c=non-essential (agree); ProteomeLM contextual percentile=0.185; target-priority score=50.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1454 ML1486 Q9CBX9 ML1486 Aminopeptidase N (EC 3.4.11.2) (Alanine aminopeptidase) (Lysyl aminopeptidase) 862 0.01648 non-essential 0.09127 non-essential high NA high_confidence_nonessential YP_177885.1 83.4 0.2824 60.814 Moderate candidate ESM-2 calibrated P(essential)=0.016; HANSEN integrated essentiality score=0.091; ProteomeLM contextual percentile=0.282; target-priority score=60.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:45Z 1455 ML2409 Q7APV1 ML2409 Possible cytochrome C biogenesis protein 327 0.06768 non-essential 0.09126 non-essential high NA high_confidence_nonessential NP_215041.2 83.1 0.0908 46.071 Exploratory ESM-2 calibrated P(essential)=0.068; HANSEN integrated essentiality score=0.091; ProteomeLM contextual percentile=0.091; target-priority score=46.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1456 ML1912 Q9CBJ4 ML1912 Glyoxylase II 238 0.06146 non-essential 0.09115 non-essential high NA high_confidence_nonessential NP_215148.1 85.3 0.1077 49.8 Exploratory ESM-2 calibrated P(essential)=0.061; HANSEN integrated essentiality score=0.091; ProteomeLM contextual percentile=0.108; target-priority score=49.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1457 ML1230 Q49618 papA3 ML1230 Condensation domain-containing protein 471 0.03604 non-essential 0.0911 non-essential high NA high_confidence_nonessential NP_215698.1 75.6 0.21728 52.106 Moderate candidate ESM-2 calibrated P(essential)=0.036; HANSEN integrated essentiality score=0.091; ProteomeLM contextual percentile=0.217; target-priority score=52.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1458 ML1381 P46835 polA ML1381 DNA polymerase I (POL I) (EC 2.7.7.7) 911 0.06652 non-essential 0.09046 non-essential high NA high_confidence_nonessential NP_216145.1 85.2 0.06825 53.945 Moderate candidate ESM-2 calibrated P(essential)=0.067; HANSEN integrated essentiality score=0.090; ProteomeLM contextual percentile=0.068; target-priority score=53.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:45Z 1459 ML0876 Q9CCF0 ctaF ML0876 Probable cytochrome c oxidase polypeptide 4 (EC 7.1.1.9) (Cytochrome aa3 subunit 4) (Cytochrome c oxidase polypeptide IV) 139 0.01172 non-essential 0.08939 non-essential high NA high_confidence_nonessential NP_216715.1 91.4 0.29869 58.947 Moderate candidate ESM-2 calibrated P(essential)=0.012; HANSEN integrated essentiality score=0.089; ProteomeLM contextual percentile=0.299; target-priority score=58.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1460 ML2705 Q7APR6 ML2705 Acetyltransferase 259 0.04123 non-essential 0.08928 non-essential high agree high_confidence_nonessential Rv3916c 77.9 NE 0 0.36631 55.825 Moderate candidate ESM-2 calibrated P(essential)=0.041; HANSEN integrated essentiality score=0.089; Mtb RBH anchor Rv3916c=non-essential (agree); ProteomeLM contextual percentile=0.366; target-priority score=55.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1461 ML2493 Q9CB24 hspR ML2493 Heat shock regulator 132 0.04386 non-essential 0.08901 non-essential high NA high_confidence_nonessential NP_214867.1 80.0 0.17658 49.556 Exploratory ESM-2 calibrated P(essential)=0.044; HANSEN integrated essentiality score=0.089; ProteomeLM contextual percentile=0.177; target-priority score=49.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1462 ML0860 O32960 ML0860 MLCB22.18 Epimerase family protein ML0860 307 0.01019 non-essential 0.0885 non-essential high NA high_confidence_nonessential NP_216732.1 84.2 0.31371 54.449 Moderate candidate ESM-2 calibrated P(essential)=0.010; HANSEN integrated essentiality score=0.089; ProteomeLM contextual percentile=0.314; target-priority score=54.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1463 ML2597 Q9CD06 ML2597 Conserved membrane protein 184 0.03424 non-essential 0.08801 non-essential high NA high_confidence_nonessential NP_214691.1 60.9 0.21227 50.432 Moderate candidate ESM-2 calibrated P(essential)=0.034; HANSEN integrated essentiality score=0.088; ProteomeLM contextual percentile=0.212; target-priority score=50.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1464 ML1505 Q9CBW9 ML1505 Conserved hypothetical Proline rich protein 182 0.01588 non-essential 0.08796 non-essential high agree high_confidence_nonessential Rv1158c 70.9 NE 0 0.50908 55.054 Moderate candidate ESM-2 calibrated P(essential)=0.016; HANSEN integrated essentiality score=0.088; Mtb RBH anchor Rv1158c=non-essential (agree); ProteomeLM contextual percentile=0.509; target-priority score=55.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1465 ML0455 Q9CCU0 ML0455 HIT domain-containing protein 206 0.05949 non-essential 0.08779 non-essential high NA high_confidence_nonessential NP_217129.1 83.2 0.10207 48.078 Exploratory ESM-2 calibrated P(essential)=0.059; HANSEN integrated essentiality score=0.088; ProteomeLM contextual percentile=0.102; target-priority score=48.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1466 ML1312 Q7AQ72 ML1312 PD-(D/E)XK endonuclease-like domain-containing protein 294 0.04476 non-essential 0.08766 non-essential high agree high_confidence_nonessential Rv2119 79.9 NE 0 0.33187 55.233 Moderate candidate ESM-2 calibrated P(essential)=0.045; HANSEN integrated essentiality score=0.088; Mtb RBH anchor Rv2119=non-essential (agree); ProteomeLM contextual percentile=0.332; target-priority score=55.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1467 ML1596 O33040 amiC ML1596 MLCB250.65 Putative amidase AmiC (EC 3.5.1.4) 468 0.02795 non-essential 0.08719 non-essential high NA high_confidence_nonessential NP_217404.1 76.9 0.20413 61.368 Moderate candidate ESM-2 calibrated P(essential)=0.028; HANSEN integrated essentiality score=0.087; ProteomeLM contextual percentile=0.204; target-priority score=61.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1468 ML2277 Q9CBA5 ML2277 Polyprenyl diphosphate synthase component 330 0.04274 non-essential 0.08698 non-essential high NA high_confidence_nonessential NP_215076.1 77.2 0.15279 55.335 Moderate candidate ESM-2 calibrated P(essential)=0.043; HANSEN integrated essentiality score=0.087; ProteomeLM contextual percentile=0.153; target-priority score=55.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1469 ML0236 Q7AQL1 pabB ML0236 Para-aminobenzoate synthase component 418 0.01761 non-essential 0.08697 non-essential high NA high_confidence_nonessential NP_215521.1 78.9 0.26863 55.145 Moderate candidate ESM-2 calibrated P(essential)=0.018; HANSEN integrated essentiality score=0.087; ProteomeLM contextual percentile=0.269; target-priority score=55.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1470 ML2435 P54579 ML2435 B2168_F1_37 Probable redox regulatory protein ML2435 277 0.03079 non-essential 0.0869 non-essential high agree high_confidence_nonessential Rv0495c 82.7 NE 0 0.40263 56.323 Moderate candidate ESM-2 calibrated P(essential)=0.031; HANSEN integrated essentiality score=0.087; Mtb RBH anchor Rv0495c=non-essential (agree); ProteomeLM contextual percentile=0.403; target-priority score=56.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1471 ML1314 Q7AQ70 ML1314 DUF503 domain-containing protein 97 0.02465 non-essential 0.08668 non-essential high agree high_confidence_nonessential Rv2117 85.6 NE 0 0.43269 57.248 Moderate candidate ESM-2 calibrated P(essential)=0.025; HANSEN integrated essentiality score=0.087; Mtb RBH anchor Rv2117=non-essential (agree); ProteomeLM contextual percentile=0.433; target-priority score=57.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1472 ML1465 Q9CBZ4 obg ML1465 GTPase Obg (EC 3.6.5.-) (GTP-binding protein Obg) 479 0.07214 non-essential 0.08656 non-essential high NA high_confidence_nonessential NP_216956.1 84.3 0.02693 51.418 Moderate candidate ESM-2 calibrated P(essential)=0.072; HANSEN integrated essentiality score=0.087; ProteomeLM contextual percentile=0.027; target-priority score=51.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1473 ML1478 Q9CBY5 ML1478 S-methylmethionine:homocysteine methyltransferase 293 0.00674 non-essential 0.08638 non-essential high NA high_confidence_nonessential NP_216974.1 79.4 0.30369 58.981 Moderate candidate ESM-2 calibrated P(essential)=0.007; HANSEN integrated essentiality score=0.086; ProteomeLM contextual percentile=0.304; target-priority score=59.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1474 ML2156 Q9CBE1 ML2156 Possible DNA-binding protein 753 0.06716 non-essential 0.08624 non-essential high agree high_confidence_nonessential Rv0862c 77.6 NE 0 0.20852 50.191 Moderate candidate ESM-2 calibrated P(essential)=0.067; HANSEN integrated essentiality score=0.086; Mtb RBH anchor Rv0862c=non-essential (agree); ProteomeLM contextual percentile=0.209; target-priority score=50.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1475 ML0687 Q7AQG0 ML0687 Membrane protein 313 0.00543 non-essential 0.0858 non-essential high NA high_confidence_nonessential NP_217852.1 68.5 0.32185 53.708 Moderate candidate ESM-2 calibrated P(essential)=0.005; HANSEN integrated essentiality score=0.086; ProteomeLM contextual percentile=0.322; target-priority score=53.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1476 ML1889 P30770 nfo end ML1889 Probable endonuclease 4 (EC 3.1.21.2) (Endodeoxyribonuclease IV) (Endonuclease IV) 252 0.04386 non-essential 0.08562 non-essential high NA high_confidence_nonessential NP_215184.1 86.0 0.12962 58.751 Moderate candidate ESM-2 calibrated P(essential)=0.044; HANSEN integrated essentiality score=0.086; ProteomeLM contextual percentile=0.130; target-priority score=58.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1477 ML0994 Q7AQB7 ML0994 Uncharacterized protein 232 0.01648 non-essential 0.08558 non-essential high agree high_confidence_nonessential Rv2728c 69.0 NE 0 0.46086 59.217 Moderate candidate ESM-2 calibrated P(essential)=0.016; HANSEN integrated essentiality score=0.086; Mtb RBH anchor Rv2728c=non-essential (agree); ProteomeLM contextual percentile=0.461; target-priority score=59.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1478 ML2689 Q7APR8 ML2689 DUF5318 domain-containing protein 138 0.00543 non-essential 0.08542 non-essential high agree high_confidence_nonessential Rv0049 83.2 NE 0 0.51972 60.381 Moderate candidate ESM-2 calibrated P(essential)=0.005; HANSEN integrated essentiality score=0.085; Mtb RBH anchor Rv0049=non-essential (agree); ProteomeLM contextual percentile=0.520; target-priority score=60.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1479 ML1632 Q9CBT2 ML1632 Possible hydrolase 511 0.03424 non-essential 0.08539 non-essential high NA high_confidence_nonessential NP_216739.1 71.9 0.19161 52.223 Moderate candidate ESM-2 calibrated P(essential)=0.034; HANSEN integrated essentiality score=0.085; ProteomeLM contextual percentile=0.192; target-priority score=52.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1480 ML2147 Q7APY2 cspB ML2147 Probable cold shock protein 136 0.03604 non-essential 0.08473 non-essential high NA high_confidence_nonessential NP_215386.1 86.8 0.1866 49.789 Exploratory ESM-2 calibrated P(essential)=0.036; HANSEN integrated essentiality score=0.085; ProteomeLM contextual percentile=0.187; target-priority score=49.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1481 ML0552 Q9CCQ0 fmt ML0552 Methionyl-tRNA formyltransferase (EC 2.1.2.9) 318 0.02518 non-essential 0.08471 non-essential high NA high_confidence_nonessential NP_215922.1 80.7 0.201 61.804 Moderate candidate ESM-2 calibrated P(essential)=0.025; HANSEN integrated essentiality score=0.085; ProteomeLM contextual percentile=0.201; target-priority score=61.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1482 ML1367 Q9CC29 ML1367 Possible regulatory protein 287 0.02734 non-essential 0.08469 non-essential high NA high_confidence_nonessential NP_216224.1 89.5 0.22417 50.515 Moderate candidate ESM-2 calibrated P(essential)=0.027; HANSEN integrated essentiality score=0.085; ProteomeLM contextual percentile=0.224; target-priority score=50.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1483 ML1390 Q9CC26 ML1390 UspA domain-containing protein 147 0.05093 non-essential 0.08467 non-essential high NA high_confidence_nonessential NP_216152.1 89.0 0.13087 45.393 Exploratory ESM-2 calibrated P(essential)=0.051; HANSEN integrated essentiality score=0.085; ProteomeLM contextual percentile=0.131; target-priority score=45.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1484 ML0826 Q9CCG4 glyS glyQS ML0826 Glycine--tRNA ligase (EC 6.1.1.14) (Glycyl-tRNA synthetase) (GlyRS) 463 0.03172 non-essential 0.08461 non-essential high NA high_confidence_nonessential NP_216873.1 90.2 0.17095 61.618 Moderate candidate ESM-2 calibrated P(essential)=0.032; HANSEN integrated essentiality score=0.085; ProteomeLM contextual percentile=0.171; target-priority score=61.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1485 ML0750 Q9CCK9 ML0750 LytR family transcriptional regulator 489 0.03949 non-essential 0.08423 non-essential high agree high_confidence_nonessential Rv3267 79.7 NE 0 0.33375 54.334 Moderate candidate ESM-2 calibrated P(essential)=0.039; HANSEN integrated essentiality score=0.084; Mtb RBH anchor Rv3267=non-essential (agree); ProteomeLM contextual percentile=0.334; target-priority score=54.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1486 ML0227 Q7AQL4 ML0227 Membrane protein 158 0.01648 non-essential 0.08403 non-essential high agree high_confidence_nonessential Rv3605c 85.4 NE 0 0.45398 57.496 Moderate candidate ESM-2 calibrated P(essential)=0.016; HANSEN integrated essentiality score=0.084; Mtb RBH anchor Rv3605c=non-essential (agree); ProteomeLM contextual percentile=0.454; target-priority score=57.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1487 ML0871 Q9CCF5 ML0871 Core domain-containing protein 118 0.09148 non-essential 0.08373 non-essential high agree high_confidence_nonessential Rv2204c 92.4 NE 0 0.06512 44.659 Exploratory ESM-2 calibrated P(essential)=0.091; HANSEN integrated essentiality score=0.084; Mtb RBH anchor Rv2204c=non-essential (agree); ProteomeLM contextual percentile=0.065; target-priority score=44.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1488 ML2709 Q7APR5 ML2709 R3H domain-containing protein 193 0.09148 non-essential 0.08371 non-essential high agree high_confidence_nonessential Rv3920c 73.1 NE 0 0.06199 45.249 Exploratory ESM-2 calibrated P(essential)=0.091; HANSEN integrated essentiality score=0.084; Mtb RBH anchor Rv3920c=non-essential (agree); ProteomeLM contextual percentile=0.062; target-priority score=45.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1489 ML0548 Q9CCQ3 priA ML0548 Probable replication restart protein PriA (Putative ATP-dependent DNA helicase PriA) 651 0.05422 non-essential 0.08346 non-essential high NA high_confidence_nonessential NP_215918.1 80.7 0.08704 52.746 Moderate candidate ESM-2 calibrated P(essential)=0.054; HANSEN integrated essentiality score=0.083; ProteomeLM contextual percentile=0.087; target-priority score=52.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1490 ML1506 Q9CBW8 ML1506 Secreted protein 348 0.00674 non-essential 0.08343 non-essential high agree high_confidence_nonessential Rv1157c 64.8 NE 0 0.51096 56.568 Moderate candidate ESM-2 calibrated P(essential)=0.007; HANSEN integrated essentiality score=0.083; Mtb RBH anchor Rv1157c=non-essential (agree); ProteomeLM contextual percentile=0.511; target-priority score=56.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1491 ML2276 Q9CBA6 ML2276 FAD-linked oxidoreductase 408 0.04823 non-essential 0.08341 non-essential high NA high_confidence_nonessential NP_215075.1 84.3 0.1196 50.923 Moderate candidate ESM-2 calibrated P(essential)=0.048; HANSEN integrated essentiality score=0.083; ProteomeLM contextual percentile=0.120; target-priority score=50.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1492 ML2590 Q9CD13 mce1B ML2590 Secreted protein 346 0.01759 non-essential 0.08318 non-essential high NA high_confidence_nonessential NP_214684.1 75.1 0.26299 49.502 Exploratory ESM-2 calibrated P(essential)=0.018; HANSEN integrated essentiality score=0.083; ProteomeLM contextual percentile=0.263; target-priority score=49.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1493 ML0625 Q49762 dnaJ2 ML0625 B1937_F2_56 Chaperone protein DnaJ 2 378 0.05767 non-essential 0.08301 non-essential high NA high_confidence_nonessential NP_216889.1 88.2 0.07389 50.935 Moderate candidate ESM-2 calibrated P(essential)=0.058; HANSEN integrated essentiality score=0.083; ProteomeLM contextual percentile=0.074; target-priority score=50.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1494 ML2227 O08361 purC ML2227 MLCB5.16 Phosphoribosylaminoimidazole-succinocarboxamide synthase (EC 6.3.2.6) (SAICAR synthetase) 297 0.04041 non-essential 0.08286 non-essential high NA high_confidence_nonessential NP_215294.1 81.5 0.12774 59.242 Moderate candidate ESM-2 calibrated P(essential)=0.040; HANSEN integrated essentiality score=0.083; ProteomeLM contextual percentile=0.128; target-priority score=59.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1495 ML0556 Q9CCP7 ML0556 Probable triacylglyceride transporter ML0556 (MFS-type drug efflux transporter P55) 509 0.06214 non-essential 0.08247 non-essential high NA high_confidence_nonessential NP_215926.1 82.0 0.06637 45.427 Exploratory ESM-2 calibrated P(essential)=0.062; HANSEN integrated essentiality score=0.082; ProteomeLM contextual percentile=0.066; target-priority score=45.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1496 ML1289 Q9CC45 ML1289 Uncharacterized protein 176 0.00198 non-essential 0.08178 non-essential high agree high_confidence_nonessential Rv2140c 86.3 NE 0 0.50282 60.621 Moderate candidate ESM-2 calibrated P(essential)=0.002; HANSEN integrated essentiality score=0.082; Mtb RBH anchor Rv2140c=non-essential (agree); ProteomeLM contextual percentile=0.503; target-priority score=60.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1497 ML1781 Q9CBN5 ML1781 DUF3145 domain-containing protein 170 0.0587 non-essential 0.08172 non-essential high agree high_confidence_nonessential Rv2256c 93.5 NE 0 0.21666 49.679 Exploratory ESM-2 calibrated P(essential)=0.059; HANSEN integrated essentiality score=0.082; Mtb RBH anchor Rv2256c=non-essential (agree); ProteomeLM contextual percentile=0.217; target-priority score=49.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1498 ML2449 Q9CB47 ML2449 Hydrolase 271 0.01889 non-essential 0.08172 non-essential high NA high_confidence_nonessential NP_214994.2 81.9 0.23482 54.14 Moderate candidate ESM-2 calibrated P(essential)=0.019; HANSEN integrated essentiality score=0.082; ProteomeLM contextual percentile=0.235; target-priority score=54.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1499 ML1391 Q9CC25 ML1391 Metallo-beta-lactamase domain-containing protein 232 0.06116 non-essential 0.0817 non-essential high agree high_confidence_nonessential Rv1637c 86.0 NE 0 0.19975 50.061 Moderate candidate ESM-2 calibrated P(essential)=0.061; HANSEN integrated essentiality score=0.082; Mtb RBH anchor Rv1637c=non-essential (agree); ProteomeLM contextual percentile=0.200; target-priority score=50.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1500 ML2446 Q9CB49 ML2446 Possible lipoprotein 441 0.03604 non-essential 0.08165 non-essential high NA high_confidence_nonessential NP_214997.1 80.2 0.14652 57.254 Moderate candidate ESM-2 calibrated P(essential)=0.036; HANSEN integrated essentiality score=0.082; ProteomeLM contextual percentile=0.147; target-priority score=57.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1501 ML1320 Q7AQ69 ML1320 Proteasome accessory factor PafA2 514 0.02734 non-essential 0.08156 non-essential high NA high_confidence_nonessential NP_216628.1 95.4 0.18284 58.291 Moderate candidate ESM-2 calibrated P(essential)=0.027; HANSEN integrated essentiality score=0.082; ProteomeLM contextual percentile=0.183; target-priority score=58.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1502 ML0483 P40833 ruvB ML0483 B1177_C3_227 Holliday junction branch migration complex subunit RuvB (EC 3.6.4.-) 349 0.06981 non-essential 0.08128 non-essential high NA high_confidence_nonessential NP_217108.1 94.4 0.00313 52.586 Moderate candidate ESM-2 calibrated P(essential)=0.070; HANSEN integrated essentiality score=0.081; ProteomeLM contextual percentile=0.003; target-priority score=52.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1503 ML2518 Q9CD39 ML2518 Transmembrane protein 130 0.04115 non-essential 0.08091 non-essential high agree high_confidence_nonessential Rv0313 78.1 GA 0 0.31183 50.076 Moderate candidate ESM-2 calibrated P(essential)=0.041; HANSEN integrated essentiality score=0.081; Mtb RBH anchor Rv0313=non-essential (agree); ProteomeLM contextual percentile=0.312; target-priority score=50.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1504 ML1120 Q9CC83 ML1120 Endonuclease GajA/Old nuclease/RecF-like AAA domain-containing protein 873 0.03424 non-essential 0.08009 non-essential high agree high_confidence_nonessential Rv1278 68.0 NE 0 0.33312 52.464 Moderate candidate ESM-2 calibrated P(essential)=0.034; HANSEN integrated essentiality score=0.080; Mtb RBH anchor Rv1278=non-essential (agree); ProteomeLM contextual percentile=0.333; target-priority score=52.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:45Z 1505 ML1612 O33021 lepB ML1612 MLCB250.39 Probable signal peptidase I (SPase I) (EC 3.4.21.89) (Leader peptidase I) 289 0.03424 non-essential 0.07996 non-essential high NA high_confidence_nonessential NP_217419.1 69.8 0.14152 58.389 Moderate candidate ESM-2 calibrated P(essential)=0.034; HANSEN integrated essentiality score=0.080; ProteomeLM contextual percentile=0.142; target-priority score=58.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1506 ML0107 Q9CDA6 aftA ML0107 Galactan 5-O-arabinofuranosyltransferase (EC 2.4.2.46) (Arabinofuranosyltransferase AftA) 632 0.02054 non-essential 0.07939 non-essential high NA high_confidence_nonessential NP_218309.1 77.5 0.18973 62.232 Moderate candidate ESM-2 calibrated P(essential)=0.021; HANSEN integrated essentiality score=0.079; ProteomeLM contextual percentile=0.190; target-priority score=62.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1507 ML1098 Q9CC95 ML1098 AAA+ ATPase domain-containing protein 1152 0.03424 non-essential 0.07936 non-essential high agree high_confidence_nonessential Rv1251c 75.5 NE 0 0.31684 54.265 Moderate candidate ESM-2 calibrated P(essential)=0.034; HANSEN integrated essentiality score=0.079; Mtb RBH anchor Rv1251c=non-essential (agree); ProteomeLM contextual percentile=0.317; target-priority score=54.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:45Z 1508 ML0095 Q9CDB5 ML0095 Integral membrane protein 302 0.01889 non-essential 0.07906 non-essential high NA high_confidence_nonessential NP_218323.1 83.8 0.22229 53.082 Moderate candidate ESM-2 calibrated P(essential)=0.019; HANSEN integrated essentiality score=0.079; ProteomeLM contextual percentile=0.222; target-priority score=53.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1509 ML0276 Q7AQK6 ML0276 Rhodanese domain-containing protein 147 0.02975 non-essential 0.07895 non-essential high agree high_confidence_nonessential Rv0390 79.0 NE 0 0.33876 54.442 Moderate candidate ESM-2 calibrated P(essential)=0.030; HANSEN integrated essentiality score=0.079; Mtb RBH anchor Rv0390=non-essential (agree); ProteomeLM contextual percentile=0.339; target-priority score=54.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1510 ML1920 Q9CBJ0 mutY ML1920 Adenine DNA glycosylase (EC 3.2.2.31) 297 0.03604 non-essential 0.0788 non-essential high NA high_confidence_nonessential NP_218106.1 74.9 0.134 55.829 Moderate candidate ESM-2 calibrated P(essential)=0.036; HANSEN integrated essentiality score=0.079; ProteomeLM contextual percentile=0.134; target-priority score=55.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1511 ML2624 O06084 pckG pckA ML2624 MLCL622.21 Phosphoenolpyruvate carboxykinase [GTP] (PEP carboxykinase) (PEPCK) (EC 4.1.1.32) 609 0.03861 non-essential 0.07871 non-essential high NA high_confidence_nonessential NP_214725.1 86.1 0.10645 60.997 Moderate candidate ESM-2 calibrated P(essential)=0.039; HANSEN integrated essentiality score=0.079; ProteomeLM contextual percentile=0.106; target-priority score=61.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1512 ML1628 O33010 ftsY ML1628 MLCB250.02 Signal recognition particle receptor FtsY (SRP receptor) (EC 3.6.5.4) 430 0.056 non-essential 0.07864 non-essential high NA high_confidence_nonessential NP_217437.1 81.2 0.04383 55.019 Moderate candidate ESM-2 calibrated P(essential)=0.056; HANSEN integrated essentiality score=0.079; ProteomeLM contextual percentile=0.044; target-priority score=55.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1513 ML1936 Q7AQ18 ychF ML1936 Ribosome-binding ATPase YchF 356 0.03861 non-essential 0.07836 non-essential high NA high_confidence_nonessential NP_215628.1 86.2 0.12899 52.633 Moderate candidate ESM-2 calibrated P(essential)=0.039; HANSEN integrated essentiality score=0.078; ProteomeLM contextual percentile=0.129; target-priority score=52.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1514 ML1254 Q7AQ78 ML1254 HNH nuclease domain-containing protein 215 0.01906 non-essential 0.07833 non-essential high agree high_confidence_nonessential Rv2469c 77.7 NE 0 0.39762 54.266 Moderate candidate ESM-2 calibrated P(essential)=0.019; HANSEN integrated essentiality score=0.078; Mtb RBH anchor Rv2469c=non-essential (agree); ProteomeLM contextual percentile=0.398; target-priority score=54.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1515 ML2563 Q7APU4 fadE5 ML2563 Broad-specificity linear acyl-CoA dehydrogenase FadE5 (EC 1.3.8.1) (EC 1.3.8.7) (EC 1.3.8.8) (Long-chain-acyl-CoA dehydrogenase) (Medium-chain-acyl-CoA dehydrogenase) (Short-chain-acyl-CoA dehydrogenase) 611 0.03604 non-essential 0.07827 non-essential high NA high_confidence_nonessential NP_214758.1 89.5 0.11835 60.09 Moderate candidate ESM-2 calibrated P(essential)=0.036; HANSEN integrated essentiality score=0.078; ProteomeLM contextual percentile=0.118; target-priority score=60.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1516 ML0682 O32874 metXA metA ML0682 MLCB1779.11 Homoserine O-acetyltransferase (HAT) (EC 2.3.1.31) (Homoserine transacetylase) (HTA) 382 0.01648 non-essential 0.07823 non-essential high NA high_confidence_nonessential NP_217858.1 85.0 0.19599 64.113 Moderate candidate ESM-2 calibrated P(essential)=0.016; HANSEN integrated essentiality score=0.078; ProteomeLM contextual percentile=0.196; target-priority score=64.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1517 ML0920 Q9CCE1 sepF ML0920 Cell division protein SepF 210 0.05247 non-essential 0.07818 non-essential high NA high_confidence_nonessential NP_216663.1 83.5 0.08453 45.768 Exploratory ESM-2 calibrated P(essential)=0.052; HANSEN integrated essentiality score=0.078; ProteomeLM contextual percentile=0.085; target-priority score=45.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1518 ML1087 Q9CCA2 ML1087 Probable ABC-transport protein, inner membrane component 304 0.03731 non-essential 0.07812 non-essential high NA high_confidence_nonessential NP_215752.1 81.8 0.14715 47.992 Exploratory ESM-2 calibrated P(essential)=0.037; HANSEN integrated essentiality score=0.078; ProteomeLM contextual percentile=0.147; target-priority score=48.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1519 ML0159 Q7AQN5 ML0159 Membrane protein 430 0.04985 non-essential 0.07807 non-essential high NA high_confidence_nonessential NP_215470.1 75.9 0.09956 44.517 Exploratory ESM-2 calibrated P(essential)=0.050; HANSEN integrated essentiality score=0.078; ProteomeLM contextual percentile=0.100; target-priority score=44.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1520 ML2064 Q7APZ7 ML2064 Integral membrane protein 316 0.00543 non-essential 0.07746 non-essential high NA high_confidence_nonessential NP_216361.1 87.9 0.27051 54.483 Moderate candidate ESM-2 calibrated P(essential)=0.005; HANSEN integrated essentiality score=0.077; ProteomeLM contextual percentile=0.271; target-priority score=54.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1521 ML1951 Q7AQ12 phoH2 ML1951 Protein PhoH2 (EC 5.6.2.5) (RNA 5'-3' helicase PhoH2) (Toxin PhoP2) 433 0.03424 non-essential 0.07724 non-essential high NA high_confidence_nonessential NP_215611.1 93.1 0.13525 55.085 Moderate candidate ESM-2 calibrated P(essential)=0.034; HANSEN integrated essentiality score=0.077; ProteomeLM contextual percentile=0.135; target-priority score=55.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1522 ML0791 Q9CCI4 ML0791 Ribosome small subunit-dependent GTPase A 327 0.05255 non-essential 0.07716 non-essential high agree high_confidence_nonessential Rv3228 84.3 NE 0 0.20038 51.184 Moderate candidate ESM-2 calibrated P(essential)=0.053; HANSEN integrated essentiality score=0.077; Mtb RBH anchor Rv3228=non-essential (agree); ProteomeLM contextual percentile=0.200; target-priority score=51.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1523 ML2465 Q9CB37 ML2465 Carboxymuconolactone decarboxylase-like domain-containing protein 188 0.02105 non-essential 0.07705 non-essential high agree high_confidence_nonessential Rv0464c 67.8 NE 0 0.36005 56.828 Moderate candidate ESM-2 calibrated P(essential)=0.021; HANSEN integrated essentiality score=0.077; Mtb RBH anchor Rv0464c=non-essential (agree); ProteomeLM contextual percentile=0.360; target-priority score=56.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1524 ML0120 Q9CD94 echA1 ML0120 Enoyl-CoA hydratase 278 0.04985 non-essential 0.07694 non-essential high NA high_confidence_nonessential NP_218291.1 88.3 0.06951 52.478 Moderate candidate ESM-2 calibrated P(essential)=0.050; HANSEN integrated essentiality score=0.077; ProteomeLM contextual percentile=0.070; target-priority score=52.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1525 ML1360 Q49896 recN ML1360 MLC1351.12c DNA repair protein RecN (Recombination protein N) 587 0.06307 non-essential 0.07684 non-essential high NA high_confidence_nonessential NP_216212.1 76.4 0.02505 46.779 Exploratory ESM-2 calibrated P(essential)=0.063; HANSEN integrated essentiality score=0.077; ProteomeLM contextual percentile=0.025; target-priority score=46.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1526 ML0488 P38386 secF ML0488 B1177_C3_239 MLCB1259.06 Protein translocase subunit SecF 471 0.0533 non-essential 0.07683 non-essential high NA high_confidence_nonessential NP_217102.1 69.6 0.07765 44.11 Exploratory ESM-2 calibrated P(essential)=0.053; HANSEN integrated essentiality score=0.077; ProteomeLM contextual percentile=0.078; target-priority score=44.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1527 ML1224 Q9CC66 ML1224 Nudix hydrolase domain-containing protein 239 0.03949 non-essential 0.07677 non-essential high agree high_confidence_nonessential Rv1593c 85.7 NE 0 0.2655 53.048 Moderate candidate ESM-2 calibrated P(essential)=0.039; HANSEN integrated essentiality score=0.077; Mtb RBH anchor Rv1593c=non-essential (agree); ProteomeLM contextual percentile=0.265; target-priority score=53.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1528 ML1302 Q49784 mshC cysS2 ML1302 B2126_C2_193 L-cysteine:1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside ligase (L-Cys:GlcN-Ins ligase) (EC 6.3.1.13) (Mycothiol ligase) (MSH ligase) 412 0.00674 non-essential 0.07637 non-essential high NA high_confidence_nonessential NP_216646.1 84.2 0.23043 63.873 Moderate candidate ESM-2 calibrated P(essential)=0.007; HANSEN integrated essentiality score=0.076; ProteomeLM contextual percentile=0.230; target-priority score=63.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1529 ML2580 Q7APT8 ML2580 Possible acyltransferase 384 0.01889 non-essential 0.07592 non-essential high NA high_confidence_nonessential NP_214742.1 79.1 0.20476 52.752 Moderate candidate ESM-2 calibrated P(essential)=0.019; HANSEN integrated essentiality score=0.076; ProteomeLM contextual percentile=0.205; target-priority score=52.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1530 ML1009 Q7AQB4 ML1009 Proteasome protein 326 0.07935 non-essential 0.07573 non-essential high agree high_confidence_nonessential Rv2714 90.2 NE 0 0.05761 44.732 Exploratory ESM-2 calibrated P(essential)=0.079; HANSEN integrated essentiality score=0.076; Mtb RBH anchor Rv2714=non-essential (agree); ProteomeLM contextual percentile=0.058; target-priority score=44.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1531 ML0238 Q9CD55 metG metS ML0238 Methionine--tRNA ligase (EC 6.1.1.10) (Methionyl-tRNA synthetase) (MetRS) 537 0.01648 non-essential 0.07507 non-essential high NA high_confidence_nonessential NP_215523.1 85.7 0.18347 62.043 Moderate candidate ESM-2 calibrated P(essential)=0.016; HANSEN integrated essentiality score=0.075; ProteomeLM contextual percentile=0.183; target-priority score=62.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1532 ML2247 Q7APX1 cpsA ML2247 Transcriptional regulator, LytR family protein 516 0.04821 non-essential 0.07491 non-essential high agree high_confidence_nonessential Rv3484 74.5 GA 0 0.21478 49.011 Exploratory ESM-2 calibrated P(essential)=0.048; HANSEN integrated essentiality score=0.075; Mtb RBH anchor Rv3484=non-essential (agree); ProteomeLM contextual percentile=0.215; target-priority score=49.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1533 ML2494 Q02605 dnaJ1 ML2494 Chaperone protein DnaJ 1 388 0.05587 non-essential 0.07436 non-essential high NA high_confidence_nonessential YP_177719.1 90.0 0.03632 49.22 Exploratory ESM-2 calibrated P(essential)=0.056; HANSEN integrated essentiality score=0.074; ProteomeLM contextual percentile=0.036; target-priority score=49.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1534 ML0323 P57990 cysS cysS1 ML0323 Cysteine--tRNA ligase (EC 6.1.1.16) (Cysteinyl-tRNA synthetase) (CysRS) 473 0.01449 non-essential 0.07414 non-essential high NA high_confidence_nonessential YP_177992.1 86.7 0.18785 61.799 Moderate candidate ESM-2 calibrated P(essential)=0.014; HANSEN integrated essentiality score=0.074; ProteomeLM contextual percentile=0.188; target-priority score=61.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1535 ML1192 Q9X7E3 acpS ML1192 MLCB458.07 Holo-[acyl-carrier-protein] synthase (Holo-ACP synthase) (EC 2.7.8.7) (4'-phosphopantetheinyl transferase AcpS) 130 0.02105 non-essential 0.07411 non-essential high NA high_confidence_nonessential NP_217039.1 87.5 0.16594 58.957 Moderate candidate ESM-2 calibrated P(essential)=0.021; HANSEN integrated essentiality score=0.074; ProteomeLM contextual percentile=0.166; target-priority score=59.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1536 ML0378 Q49857 ML0378 B229_C1_170 Uncharacterized protein ML0378 359 0.03604 non-essential 0.07336 non-essential high agree high_confidence_nonessential Rv3421c 75.6 NE 0 0.25047 53.373 Moderate candidate ESM-2 calibrated P(essential)=0.036; HANSEN integrated essentiality score=0.073; Mtb RBH anchor Rv3421c=non-essential (agree); ProteomeLM contextual percentile=0.250; target-priority score=53.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1537 ML0763 Q9CCJ7 pmmA ML0763 Phosphomannomutase 468 0.03604 non-essential 0.07261 non-essential high NA high_confidence_nonessential NP_217774.1 83.1 0.11459 50.031 Moderate candidate ESM-2 calibrated P(essential)=0.036; HANSEN integrated essentiality score=0.073; ProteomeLM contextual percentile=0.115; target-priority score=50.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1538 ML2679 Q7APS0 ML2679 Uncharacterized protein 893 0.02518 non-essential 0.07225 non-essential high agree high_confidence_nonessential Rv2567 75.2 NE 0 0.31058 52.166 Moderate candidate ESM-2 calibrated P(essential)=0.025; HANSEN integrated essentiality score=0.072; Mtb RBH anchor Rv2567=non-essential (agree); ProteomeLM contextual percentile=0.311; target-priority score=52.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:45Z 1539 ML1300 Q9CC40 ML1300 Phosphatidylinositol kinase 262 0.02105 non-essential 0.07202 non-essential high agree high_confidence_nonessential Rv2133c 79.8 NE 0 0.31747 55.291 Moderate candidate ESM-2 calibrated P(essential)=0.021; HANSEN integrated essentiality score=0.072; Mtb RBH anchor Rv2133c=non-essential (agree); ProteomeLM contextual percentile=0.317; target-priority score=55.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1540 ML2213 Q50022 apeB pepC pepX ML2213 MLCB5.29 Probable M18 family aminopeptidase 2 (EC 3.4.11.-) 426 0.03424 non-essential 0.07188 non-essential high NA high_confidence_nonessential NP_215315.1 77.6 0.10394 55.013 Moderate candidate ESM-2 calibrated P(essential)=0.034; HANSEN integrated essentiality score=0.072; ProteomeLM contextual percentile=0.104; target-priority score=55.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1541 ML1333 Q9ZBD8 helY ML1333 MLCB2533.29 Probable helicase HelY (EC 3.6.4.-) 920 0.05547 non-essential 0.07183 non-essential high NA high_confidence_nonessential NP_216608.1 81.5 0.02066 50.094 Moderate candidate ESM-2 calibrated P(essential)=0.055; HANSEN integrated essentiality score=0.072; ProteomeLM contextual percentile=0.021; target-priority score=50.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:45Z 1542 ML1782 Q9CBN4 ML1782 Beta-lactamase-related domain-containing protein 273 0.04563 non-essential 0.07169 non-essential high agree high_confidence_nonessential Rv2257c 76.4 NE 0 0.19286 50.06 Moderate candidate ESM-2 calibrated P(essential)=0.046; HANSEN integrated essentiality score=0.072; Mtb RBH anchor Rv2257c=non-essential (agree); ProteomeLM contextual percentile=0.193; target-priority score=50.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1543 ML1731 Q9CBQ2 nrdF ML1731 Ribonucleoside-diphosphate reductase subunit beta (EC 1.17.4.1) (Ribonucleotide reductase small subunit) 325 0.05767 non-essential 0.07168 non-essential high NA high_confidence_nonessential YP_177921.1 93.5 0.00063 53.186 Moderate candidate ESM-2 calibrated P(essential)=0.058; HANSEN integrated essentiality score=0.072; ProteomeLM contextual percentile=0.001; target-priority score=53.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1544 ML0583 P46708 tkt ML0583 B1496_F1_26 MLCL536.38 Transketolase (TK) (EC 2.2.1.1) 699 0.0533 non-essential 0.07105 non-essential high NA high_confidence_nonessential NP_215965.1 89.3 0.01252 54.706 Moderate candidate ESM-2 calibrated P(essential)=0.053; HANSEN integrated essentiality score=0.071; ProteomeLM contextual percentile=0.013; target-priority score=54.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1545 ML1002 Q7AQB6 ML1002 Possible conserved membrane protein 687 0.06278 non-essential 0.071 non-essential high agree high_confidence_nonessential Rv2721c 61.9 NE 0 0.11396 43.869 Exploratory ESM-2 calibrated P(essential)=0.063; HANSEN integrated essentiality score=0.071; Mtb RBH anchor Rv2721c=non-essential (agree); ProteomeLM contextual percentile=0.114; target-priority score=43.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1546 ML1444 Q9CC04 ML1444 Possible dienelactone hydrolase 232 0.02105 non-essential 0.07077 non-essential high agree high_confidence_nonessential Rv2054 76.1 GA 0 0.29931 56.414 Moderate candidate ESM-2 calibrated P(essential)=0.021; HANSEN integrated essentiality score=0.071; Mtb RBH anchor Rv2054=non-essential (agree); ProteomeLM contextual percentile=0.299; target-priority score=56.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1547 ML2333 Q7APW3 ML2333 Delta(24)-sterol reductase (EC 1.3.1.72) 459 0.05275 non-essential 0.07075 non-essential high agree high_confidence_nonessential Rv3719 82.8 NE 0 0.12523 53.153 Moderate candidate ESM-2 calibrated P(essential)=0.053; HANSEN integrated essentiality score=0.071; Mtb RBH anchor Rv3719=non-essential (agree); ProteomeLM contextual percentile=0.125; target-priority score=53.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1548 ML0607 Q49757 ML0607 B1937_F2_39 MLCL536.03c Uncharacterized protein ML0607 279 0.07572 non-essential 0.07072 non-essential high agree high_confidence_nonessential Rv2409c 82.1 NE 0 0.03256 44.056 Exploratory ESM-2 calibrated P(essential)=0.076; HANSEN integrated essentiality score=0.071; Mtb RBH anchor Rv2409c=non-essential (agree); ProteomeLM contextual percentile=0.033; target-priority score=44.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1549 ML0816 Q9CCG9 ML0816 Peptidase metallopeptidase domain-containing protein 341 0.03949 non-essential 0.07032 non-essential high agree high_confidence_nonessential Rv3207c 80.6 NE 0 0.21791 49.671 Exploratory ESM-2 calibrated P(essential)=0.039; HANSEN integrated essentiality score=0.070; Mtb RBH anchor Rv3207c=non-essential (agree); ProteomeLM contextual percentile=0.218; target-priority score=49.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1550 ML0765 Q9CCJ5 manA ML0765 mannose-6-phosphate isomerase (EC 5.3.1.8) 410 0.03949 non-essential 0.06985 non-essential high NA high_confidence_nonessential NP_217772.1 82.7 0.0645 56.171 Moderate candidate ESM-2 calibrated P(essential)=0.039; HANSEN integrated essentiality score=0.070; ProteomeLM contextual percentile=0.064; target-priority score=56.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1551 ML0849 Q7AQF0 ML0849 Cobalt transport protein 283 0.03604 non-essential 0.0697 non-essential high agree high_confidence_nonessential Rv2325c 77.9 NE 0 0.23106 49.938 Exploratory ESM-2 calibrated P(essential)=0.036; HANSEN integrated essentiality score=0.070; Mtb RBH anchor Rv2325c=non-essential (agree); ProteomeLM contextual percentile=0.231; target-priority score=49.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1552 ML1352 Q49900 tyrS ML1352 MLC1351.16c Tyrosine--tRNA ligase (EC 6.1.1.1) (Tyrosyl-tRNA synthetase) (TyrRS) 426 0.03424 non-essential 0.06919 non-essential high NA high_confidence_nonessential NP_216205.1 83.8 0.07952 57.931 Moderate candidate ESM-2 calibrated P(essential)=0.034; HANSEN integrated essentiality score=0.069; ProteomeLM contextual percentile=0.080; target-priority score=57.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1553 ML1380 Q7AQ58 ML1380 Uncharacterized protein 187 0.03949 non-essential 0.0687 non-essential high agree high_confidence_nonessential Rv1780 82.4 GA 0 0.20351 49.306 Exploratory ESM-2 calibrated P(essential)=0.039; HANSEN integrated essentiality score=0.069; Mtb RBH anchor Rv1780=non-essential (agree); ProteomeLM contextual percentile=0.204; target-priority score=49.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1554 ML2142 Q7APY4 ML2142 DUF3027 domain-containing protein 269 0.03604 non-essential 0.06832 non-essential high agree high_confidence_nonessential Rv0877 80.9 GA 0 0.22542 48.319 Exploratory ESM-2 calibrated P(essential)=0.036; HANSEN integrated essentiality score=0.068; Mtb RBH anchor Rv0877=non-essential (agree); ProteomeLM contextual percentile=0.225; target-priority score=48.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1555 ML2442 P54139 ML2442 B2168_C3_245 u2168e Uncharacterized protein ML2442 184 0.03604 non-essential 0.06829 non-essential high agree high_confidence_nonessential Rv0487 73.1 NE 0 0.21853 49.624 Exploratory ESM-2 calibrated P(essential)=0.036; HANSEN integrated essentiality score=0.068; Mtb RBH anchor Rv0487=non-essential (agree); ProteomeLM contextual percentile=0.219; target-priority score=49.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1556 ML2507 Q9CB17 dcd ML2507 dCTP deaminase, dUMP-forming (EC 3.5.4.30) (Bifunctional dCTP deaminase:dUTPase) (DCD-DUT) 190 0.02105 non-essential 0.06808 non-essential high NA high_confidence_nonessential NP_214835.1 90.0 0.12398 61.159 Moderate candidate ESM-2 calibrated P(essential)=0.021; HANSEN integrated essentiality score=0.068; ProteomeLM contextual percentile=0.124; target-priority score=61.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1557 ML0584 Q9CCN4 ctaB ML0584 Protoheme IX farnesyltransferase (EC 2.5.1.141) (Heme B farnesyltransferase) (Heme O synthase) 308 0.01861 non-essential 0.06791 non-essential high NA high_confidence_nonessential NP_215967.1 85.6 0.14026 59.084 Moderate candidate ESM-2 calibrated P(essential)=0.019; HANSEN integrated essentiality score=0.068; ProteomeLM contextual percentile=0.140; target-priority score=59.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1558 ML0161 Q9Z5H5 purH ML0161 MLCB373.09 Bifunctional purine biosynthesis protein PurH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase (EC 2.1.2.3) (AICAR transformylase); IMP cyclohydrolase (EC 3.5.4.10) (ATIC) (IMP synthase) (Inosinicase)] 527 0.03769 non-essential 0.06693 non-essential high NA high_confidence_nonessential NP_215472.1 88.1 0.05197 57.39 Moderate candidate ESM-2 calibrated P(essential)=0.038; HANSEN integrated essentiality score=0.067; ProteomeLM contextual percentile=0.052; target-priority score=57.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1559 ML0003 P46391 recF ML0003 DNA replication and repair protein RecF 385 0.05255 non-essential 0.0665 non-essential high NA high_confidence_nonessential NP_214517.1 76.6 0.00689 48.67 Exploratory ESM-2 calibrated P(essential)=0.053; HANSEN integrated essentiality score=0.066; ProteomeLM contextual percentile=0.007; target-priority score=48.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1560 ML2410 Q9CB62 ML2410 Conserved membrane protein 542 0.04552 non-essential 0.06554 non-essential high NA high_confidence_nonessential NP_215042.1 80.9 0.04571 44.516 Exploratory ESM-2 calibrated P(essential)=0.046; HANSEN integrated essentiality score=0.066; ProteomeLM contextual percentile=0.046; target-priority score=44.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1561 ML1313 Q7AQ71 ML1313 tRNA (adenine(58)-N(1))-methyltransferase TrmI (EC 2.1.1.220) 281 0.04818 non-essential 0.06552 non-essential high NA high_confidence_nonessential NP_216634.1 84.3 0.00626 53.755 Moderate candidate ESM-2 calibrated P(essential)=0.048; HANSEN integrated essentiality score=0.066; ProteomeLM contextual percentile=0.006; target-priority score=53.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1562 ML2427 P54878 ML2427 B2168_C1_175 Uncharacterized protein ML2427 367 0.0393 non-essential 0.0651 non-essential high agree high_confidence_nonessential Rv0502 85.2 NE 0 0.16781 49.464 Exploratory ESM-2 calibrated P(essential)=0.039; HANSEN integrated essentiality score=0.065; Mtb RBH anchor Rv0502=non-essential (agree); ProteomeLM contextual percentile=0.168; target-priority score=49.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1563 ML1131 P45836 thrB ML1131 Homoserine kinase (HK) (HSK) (EC 2.7.1.39) 315 0.03424 non-essential 0.06467 non-essential high NA high_confidence_nonessential NP_215812.1 82.0 0.05009 58.901 Moderate candidate ESM-2 calibrated P(essential)=0.034; HANSEN integrated essentiality score=0.065; ProteomeLM contextual percentile=0.050; target-priority score=58.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1564 ML1908 Q9CBJ8 ML1908 UPF0336 protein ML1908 166 0.03949 non-essential 0.06407 non-essential high NA high_confidence_nonessential NP_215151.1 89.2 0.06137 45.678 Exploratory ESM-2 calibrated P(essential)=0.039; HANSEN integrated essentiality score=0.064; ProteomeLM contextual percentile=0.061; target-priority score=45.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1565 ML2235 Q50144 purD ML2235 MLCB5.08 Phosphoribosylamine--glycine ligase (EC 6.3.4.13) (GARS) (Glycinamide ribonucleotide synthetase) (Phosphoribosylglycinamide synthetase) 422 0.03604 non-essential 0.06394 non-essential high NA high_confidence_nonessential NP_215286.1 82.0 0.03882 58.468 Moderate candidate ESM-2 calibrated P(essential)=0.036; HANSEN integrated essentiality score=0.064; ProteomeLM contextual percentile=0.039; target-priority score=58.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1566 ML0792 Q9CCI3 aroA ML0792 3-phosphoshikimate 1-carboxyvinyltransferase (EC 2.5.1.19) (5-enolpyruvylshikimate-3-phosphate synthase) (EPSP synthase) (EPSPS) 430 0.03924 non-essential 0.06316 non-essential high NA high_confidence_nonessential NP_217744.1 79.0 0.02192 57.654 Moderate candidate ESM-2 calibrated P(essential)=0.039; HANSEN integrated essentiality score=0.063; ProteomeLM contextual percentile=0.022; target-priority score=57.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1567 ML1305 Q7AQ73 ansP2 ML1305 Probable L-asparagine permease 505 0.01172 non-essential 0.06294 non-essential high NA high_confidence_nonessential 0.17157 49.268 Exploratory ESM-2 calibrated P(essential)=0.012; HANSEN integrated essentiality score=0.063; ProteomeLM contextual percentile=0.172; target-priority score=49.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1568 ML0762 Q9CCJ8 ML0762 DUF3499 domain-containing protein 165 0.01648 non-essential 0.06277 non-essential high agree high_confidence_nonessential Rv3258c 76.2 NE 0 0.28491 48.79 Exploratory ESM-2 calibrated P(essential)=0.016; HANSEN integrated essentiality score=0.063; Mtb RBH anchor Rv3258c=non-essential (agree); ProteomeLM contextual percentile=0.285; target-priority score=48.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1569 ML2186 Q50049 dus ML2186 Probable tRNA-dihydrouridine synthase (EC 1.3.1.-) 384 0.03424 non-essential 0.06258 non-essential high NA high_confidence_nonessential NP_215338.1 82.3 0.04634 55.992 Moderate candidate ESM-2 calibrated P(essential)=0.034; HANSEN integrated essentiality score=0.063; ProteomeLM contextual percentile=0.046; target-priority score=56.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1570 ML0508 Q9CCT2 ML0508 Transglutaminase-like domain-containing protein 313 0.02734 non-essential 0.06231 non-essential high agree high_confidence_nonessential Rv2569c 84.9 NE 0 0.21039 49.723 Exploratory ESM-2 calibrated P(essential)=0.027; HANSEN integrated essentiality score=0.062; Mtb RBH anchor Rv2569c=non-essential (agree); ProteomeLM contextual percentile=0.210; target-priority score=49.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1571 ML1332 P54078 tatC mttB ML1332 B2126_C1_183 MLCB2533.28 u2126a Sec-independent protein translocase protein TatC 310 0.01019 non-essential 0.06205 non-essential high NA high_confidence_nonessential NP_216609.1 84.5 0.17533 48.6 Exploratory ESM-2 calibrated P(essential)=0.010; HANSEN integrated essentiality score=0.062; ProteomeLM contextual percentile=0.175; target-priority score=48.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1572 ML1064 Q9CCA9 ML1064 Glucosyl-3-phosphoglycerate synthase (EC 2.4.1.266) 326 0.03604 non-essential 0.06195 non-essential high NA high_confidence_nonessential NP_215724.1 79.8 0.04446 52.563 Moderate candidate ESM-2 calibrated P(essential)=0.036; HANSEN integrated essentiality score=0.062; ProteomeLM contextual percentile=0.044; target-priority score=52.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1573 ML1561 Q7AQ41 ML1561 DUF4439 domain-containing protein 165 0.01019 non-essential 0.06109 non-essential high agree high_confidence_nonessential Rv2844 71.5 NE 0 0.28867 52.223 Moderate candidate ESM-2 calibrated P(essential)=0.010; HANSEN integrated essentiality score=0.061; Mtb RBH anchor Rv2844=non-essential (agree); ProteomeLM contextual percentile=0.289; target-priority score=52.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1574 ML0192 Q9CD61 ML0192 Polyprenol-phosphate-mannose--protein mannosyltransferase (EC 2.4.1.-) 510 0.01889 non-essential 0.06052 non-essential high NA high_confidence_nonessential NP_215518.1 79.0 0.1052 55.806 Moderate candidate ESM-2 calibrated P(essential)=0.019; HANSEN integrated essentiality score=0.061; ProteomeLM contextual percentile=0.105; target-priority score=55.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1575 ML1231 Q49619 mmpL10 tp1 ML1231 B1170_C1_181 Probable transport protein MmpL10 1008 0.02862 non-essential 0.06001 non-essential high NA high_confidence_nonessential NP_215699.1 68.4 0.08516 46.411 Exploratory ESM-2 calibrated P(essential)=0.029; HANSEN integrated essentiality score=0.060; ProteomeLM contextual percentile=0.085; target-priority score=46.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:45Z 1576 ML1123 Q9CC80 ML1123 Oligopeptide transport system permease protein OppC 299 0.00543 non-essential 0.05973 non-essential high NA high_confidence_nonessential NP_215798.1 82.6 0.17971 49.89 Exploratory ESM-2 calibrated P(essential)=0.005; HANSEN integrated essentiality score=0.060; ProteomeLM contextual percentile=0.180; target-priority score=49.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1577 ML1304 Q7AQ74 ansP1 ML1304 Probable L-asparagine permease 498 0.01172 non-essential 0.05972 non-essential high NA high_confidence_nonessential YP_177863.1 83.3 0.15404 48.781 Exploratory ESM-2 calibrated P(essential)=0.012; HANSEN integrated essentiality score=0.060; ProteomeLM contextual percentile=0.154; target-priority score=48.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1578 ML1117 Q9CC85 ML1117 Uncharacterized protein ML1117 (EC 3.1.3.-) 161 0.00502 non-essential 0.05926 non-essential high agree high_confidence_nonessential Rv1276c 65.4 NE 0 0.26988 58.524 Moderate candidate ESM-2 calibrated P(essential)=0.005; HANSEN integrated essentiality score=0.059; Mtb RBH anchor Rv1276c=non-essential (agree); ProteomeLM contextual percentile=0.270; target-priority score=58.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1579 ML1631 Q9CBT3 glnA2 ML1631 Glutamine synthetase (EC 6.3.1.2) (Glutamate--ammonia ligase) (Glutamine synthetase I alpha) 448 0.02734 non-essential 0.0589 non-essential high NA high_confidence_nonessential NP_216738.1 93.3 0.05823 55.345 Moderate candidate ESM-2 calibrated P(essential)=0.027; HANSEN integrated essentiality score=0.059; ProteomeLM contextual percentile=0.058; target-priority score=55.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1580 ML0563 Q9CCP0 ML0563 Nucleotide-binding protein ML0563 298 0.04552 non-essential 0.05888 non-essential high agree high_confidence_nonessential Rv1421 92.3 NE 0 0.07577 47.98 Exploratory ESM-2 calibrated P(essential)=0.046; HANSEN integrated essentiality score=0.059; Mtb RBH anchor Rv1421=non-essential (agree); ProteomeLM contextual percentile=0.076; target-priority score=48.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1581 ML2302 Q9CB91 ML2302 CRP-like cAMP-activated global transcriptional regulator (cAMP receptor protein) (cAMP regulatory protein) 224 0.03924 non-essential 0.05744 non-essential high NA high_confidence_nonessential NP_218193.1 96.4 0.02317 45.793 Exploratory ESM-2 calibrated P(essential)=0.039; HANSEN integrated essentiality score=0.057; ProteomeLM contextual percentile=0.023; target-priority score=45.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1582 ML2084 Q7APZ0 ML2084 Probable multidrug resistance pump 638 0.03604 non-essential 0.05719 non-essential high NA high_confidence_nonessential NP_216335.1 73.1 0.0382 45.167 Exploratory ESM-2 calibrated P(essential)=0.036; HANSEN integrated essentiality score=0.057; ProteomeLM contextual percentile=0.038; target-priority score=45.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1583 ML0605 Q49755 ML0605 B1937_F1_4 MLCL536.05c u1937b Uncharacterized protein ML0605 561 0.03949 non-essential 0.0559 non-essential high agree high_confidence_nonessential Rv2411c 88.6 GA 0 0.09643 45.135 Exploratory ESM-2 calibrated P(essential)=0.039; HANSEN integrated essentiality score=0.056; Mtb RBH anchor Rv2411c=non-essential (agree); ProteomeLM contextual percentile=0.096; target-priority score=45.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1584 ML1644 Q7AQ36 ML1644 SURF1-like protein 270 0.01828 non-essential 0.05534 non-essential high NA high_confidence_nonessential NP_216751.1 74.2 0.10332 47.04 Exploratory ESM-2 calibrated P(essential)=0.018; HANSEN integrated essentiality score=0.055; ProteomeLM contextual percentile=0.103; target-priority score=47.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1585 ML2425 P54879 ML2425 B2168_F2_80 UPF0336 protein ML2425 166 0.01993 non-essential 0.05423 non-essential high agree high_confidence_nonessential Rv0504c 83.1 NE 0 0.18222 48.111 Exploratory ESM-2 calibrated P(essential)=0.020; HANSEN integrated essentiality score=0.054; Mtb RBH anchor Rv0504c=non-essential (agree); ProteomeLM contextual percentile=0.182; target-priority score=48.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1586 ML2135 Q7APY7 ML2135 Possible transmembrane protein 341 0.03769 non-essential 0.05286 non-essential high agree high_confidence_nonessential Rv0885 83.9 NE 0 0.06387 47.728 Exploratory ESM-2 calibrated P(essential)=0.038; HANSEN integrated essentiality score=0.053; Mtb RBH anchor Rv0885=non-essential (agree); ProteomeLM contextual percentile=0.064; target-priority score=47.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1587 ML1040 Q7AQA4 ML1040 HRDC domain-containing protein 429 0.03172 non-essential 0.0525 non-essential high agree high_confidence_nonessential Rv2681 72.4 NE 0 0.09768 47.406 Exploratory ESM-2 calibrated P(essential)=0.032; HANSEN integrated essentiality score=0.053; Mtb RBH anchor Rv2681=non-essential (agree); ProteomeLM contextual percentile=0.098; target-priority score=47.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1588 ML0184 Q9CD65 rimJ ML0184 Possible acetyltransferase 214 0.01019 non-essential 0.05183 non-essential high NA high_confidence_nonessential NP_215510.1 86.0 0.11146 49.865 Exploratory ESM-2 calibrated P(essential)=0.010; HANSEN integrated essentiality score=0.052; ProteomeLM contextual percentile=0.111; target-priority score=49.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1589 ML2298 Q9CB95 ML2298 Membrane-associated serine protease 401 0.02975 non-essential 0.05073 non-essential high NA high_confidence_nonessential NP_218188.1 75.6 0.02755 45.678 Exploratory ESM-2 calibrated P(essential)=0.030; HANSEN integrated essentiality score=0.051; ProteomeLM contextual percentile=0.028; target-priority score=45.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1590 ML0642 Q49746 ML0642 Hydrolase 479 0.02734 non-essential 0.05007 non-essential high agree high_confidence_nonessential Rv3195 78.5 NE 0 0.10833 45.663 Exploratory ESM-2 calibrated P(essential)=0.027; HANSEN integrated essentiality score=0.050; Mtb RBH anchor Rv3195=non-essential (agree); ProteomeLM contextual percentile=0.108; target-priority score=45.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1591 ML0112 Q9CDA2 ML0112 ABC transporter component 276 0.00198 non-essential 0.04976 non-essential high NA high_confidence_nonessential NP_218300.1 84.3 0.14089 48.53 Exploratory ESM-2 calibrated P(essential)=0.002; HANSEN integrated essentiality score=0.050; ProteomeLM contextual percentile=0.141; target-priority score=48.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1592 ML1041 Q7AQA3 ML1041 DUF3000 domain-containing protein 196 0.02734 non-essential 0.04902 non-essential high agree high_confidence_nonessential Rv2680 83.9 NE 0 0.10019 45.193 Exploratory ESM-2 calibrated P(essential)=0.027; HANSEN integrated essentiality score=0.049; Mtb RBH anchor Rv2680=non-essential (agree); ProteomeLM contextual percentile=0.100; target-priority score=45.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1593 ML0028 Q50191 ML0028 UPF0301 protein ML0028 202 0.04206 non-essential 0.04883 non-essential high agree high_confidence_nonessential Rv0038 88.6 NE 0 0.01565 44.055 Exploratory ESM-2 calibrated P(essential)=0.042; HANSEN integrated essentiality score=0.049; Mtb RBH anchor Rv0038=non-essential (agree); ProteomeLM contextual percentile=0.016; target-priority score=44.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1594 ML1413 Q9CC09 argH ML1413 Argininosuccinate lyase (ASAL) (EC 4.3.2.1) (Arginosuccinase) 470 0.01364 non-essential 0.04649 non-essential high NA high_confidence_nonessential NP_216175.1 88.1 0.04508 56.371 Moderate candidate ESM-2 calibrated P(essential)=0.014; HANSEN integrated essentiality score=0.046; ProteomeLM contextual percentile=0.045; target-priority score=56.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1595 ML2429 Q7APU8 ML2429 Possible DNA-binding protein 86 0.01889 non-essential 0.03693 non-essential high NA high_confidence_nonessential YP_177624.1 82.6 0.01002 40.998 Exploratory ESM-2 calibrated P(essential)=0.019; HANSEN integrated essentiality score=0.037; ProteomeLM contextual percentile=0.010; target-priority score=41.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1596 ML2604 Q9CD02 ML2604 Uncharacterized protein 249 0.01019 non-essential 0.03664 non-essential high agree high_confidence_nonessential Rv0184 81.9 NE 0 0.08391 44.271 Exploratory ESM-2 calibrated P(essential)=0.010; HANSEN integrated essentiality score=0.037; Mtb RBH anchor Rv0184=non-essential (agree); ProteomeLM contextual percentile=0.084; target-priority score=44.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1597 ML1624 O33011 ML1624 MLCB250.18c Uncharacterized protein ML1624 596 0.01019 non-essential 0.03453 non-essential high agree high_confidence_nonessential Rv2917 79.9 NE 0 0.0526 46.303 Exploratory ESM-2 calibrated P(essential)=0.010; HANSEN integrated essentiality score=0.035; Mtb RBH anchor Rv2917=non-essential (agree); ProteomeLM contextual percentile=0.053; target-priority score=46.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1598 ML1582 Q9CBU4 rip1 ML1582 Zinc metalloprotease Rip1 (EC 3.4.24.-) (S2P endopeptidase) (Site-2 protease Rip1) (S2P protease Rip1) (Site-2-type intramembrane protease) 404 0.00543 non-essential 0.0344 non-essential high NA high_confidence_nonessential NP_217385.1 82.2 0.02567 51.61 Moderate candidate ESM-2 calibrated P(essential)=0.005; HANSEN integrated essentiality score=0.034; ProteomeLM contextual percentile=0.026; target-priority score=51.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z 1599 ML0831 Q9CCG3 ML0831 Deoxyguanosinetriphosphate triphosphohydrolase-like protein 429 0.01019 non-essential 0.03306 non-essential high NA high_confidence_nonessential NP_216860.1 84.4 0.0119 46.168 Exploratory ESM-2 calibrated P(essential)=0.010; HANSEN integrated essentiality score=0.033; ProteomeLM contextual percentile=0.012; target-priority score=46.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z