rank ml_id entry gene_names protein_names sequence_length target_priority_score priority_tier proteomelm_context_score proteomelm_signal_source context_shift_norm binding_site_score pocket_count pocket_best_score af2bind_residue_count af2bind_high_residue_count af2bind_max_pbind model_quality_score model_quality_value annotation_score tractability_score ec_number pathway matched_terms_text rationale detail_url computed_at 1 ML1985 P46831 aceA ML1985 Isocitrate lyase (ICL) (EC 4.1.3.1) (Isocitrase) (Isocitratase) 606 86.899 High-priority 0.8647 ProteomeLM contextual shift 0.22721307 1.0 291 1.0 1600 8 0.6821 0.8836 88.36 0.64 1.0 4.1.3.1 PATHWAY: Carbohydrate metabolism; glyoxylate cycle; (S)-malate from isocitrate: step 1/2. {ECO:0000250|UniProtKB:P9WKK7}. lyase, cofactor ProteomeLM contextual percentile 0.86; strong pocket/AF2Bind evidence; essential-process annotation; high-confidence Boltz2 model; matched: lyase, cofactor /main_page_ml/ML1985 2026-05-30T13:09:52Z 2 ML1199 Q9X7E7 lspA ML1199 MLCB458.14 Lipoprotein signal peptidase (EC 3.4.23.36) (Prolipoprotein signal peptidase) (Signal peptidase II) (SPase II) 201 85.386 High-priority 0.8346 ProteomeLM contextual shift 0.1919078 1.0 28 1.0 637 68 0.9694 0.7475 74.75 0.685 1.0 3.4.23.36 PATHWAY: Protein modification; lipoprotein biosynthesis (signal peptide cleavage). {ECO:0000255|HAMAP-Rule:MF_00161}. signal peptidase ProteomeLM contextual percentile 0.83; strong pocket/AF2Bind evidence; essential-process annotation; matched: signal peptidase /main_page_ml/ML1199 2026-05-30T13:09:52Z 3 ML1328 P54077 pafA ML1328 B2126_C2_219 MLCB2533.24 Pup--protein ligase (EC 6.3.1.19) (Proteasome accessory factor A) (Pup-conjugating enzyme) 452 84.816 High-priority 0.7669 ProteomeLM contextual shift 0.15675157 1.0 130 1.0 1359 6 0.7223 0.9274 92.74 0.685 1.0 6.3.1.19 PATHWAY: Protein degradation; proteasomal Pup-dependent pathway. {ECO:0000255|HAMAP-Rule:MF_02111}.; PATHWAY: Protein modification; protein pupylation. {ECO:0000255|HAMAP-Rule:MF_02111}. proteasome, enzyme, ligase, transferase ProteomeLM contextual percentile 0.77; strong pocket/AF2Bind evidence; essential-process annotation; high-confidence Boltz2 model; matched: proteasome, enzyme, ligase, transferase /main_page_ml/ML1328 2026-05-30T13:09:52Z 4 ML0918 Q9CCE3 ML0918 Purine nucleoside phosphorylase ML0918 (EC 2.4.2.1) (Adenosine deaminase ML0918) (EC 3.5.4.4) (S-methyl-5'-thioadenosine phosphorylase ML0918) (EC 2.4.2.28) 249 84.786 High-priority 0.9292 ProteomeLM contextual shift 0.48523405 1.0 50 1.0 774 54 0.9495 0.7664 76.64 0.48 1.0 2.4.2.1; 2.4.2.28; 3.5.4.4 oxidoreductase, reductase, cofactor ProteomeLM contextual percentile 0.93; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model; matched: oxidoreductase, reductase, cofactor /main_page_ml/ML0918 2026-05-30T13:09:52Z 5 ML1965 Q7AQ10 rmlC ML1965 dTDP-4-dehydrorhamnose 3,5-epimerase (EC 5.1.3.13) (Thymidine diphospho-4-keto-rhamnose 3,5-epimerase) 202 84.528 High-priority 0.7744 ProteomeLM contextual shift 0.15914577 1.0 46 1.0 621 30 0.7498 0.9623 96.23 0.64 1.0 5.1.3.13 PATHWAY: Carbohydrate biosynthesis; dTDP-L-rhamnose biosynthesis. {ECO:0000256|ARBA:ARBA00004781, ECO:0000256|RuleBase:RU364069}. ProteomeLM contextual percentile 0.77; strong pocket/AF2Bind evidence; essential-process annotation; high-confidence Boltz2 model /main_page_ml/ML1965 2026-05-30T13:09:52Z 6 ML1611 O33022 rnhB ML1611 MLCB250.40 Ribonuclease HII (RNase HII) (EC 3.1.26.4) 240 83.926 High-priority 0.8452 ProteomeLM contextual shift 0.20062962 1.0 30 1.0 505 50 0.8187 0.7942 79.42 0.57 1.0 3.1.26.4 dna replication, replication, cofactor ProteomeLM contextual percentile 0.85; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model; matched: dna replication, replication, cofactor /main_page_ml/ML1611 2026-05-30T13:09:52Z 7 ML2353 Q49934 ML2353 Phenolphthiocerol/phthiocerol polyketide synthase subunit E (EC 2.3.1.292) ((Phenol)carboxyphthiodiolenone synthase subunit E) (Beta-ketoacyl-acyl-carrier-protein synthase I) (Phthiocerol synthesis polyketide synthase type I PpsE) 1489 83.821 High-priority 0.807 ProteomeLM contextual shift 0.17144334 1.0 182 1.0 1491 4 0.5565 0.8226 82.26 0.7 0.835 2.3.1.292 PATHWAY: Lipid metabolism; fatty acid biosynthesis. {ECO:0000256|ARBA:ARBA00005194}. cell wall, nad, lipid metabolism, fatty acid biosynthesis, oxidoreductase, reductase, synthase ProteomeLM contextual percentile 0.81; strong pocket/AF2Bind evidence; essential-process annotation; high-confidence Boltz2 model; matched: cell wall, nad, lipid metabolism, fatty acid biosynthesis, oxidoreductase /main_page_ml/ML2353 2026-05-30T13:09:52Z 8 ML1417 Q9CC08 cdh ML1417 Probable CDP-diacylglycerol pyrophosphatase (EC 3.6.1.26) (CDP-diacylglycerol phosphatidylhydrolase) (CDP-diglyceride hydrolase) 268 83.702 High-priority 0.8277 ProteomeLM contextual shift 0.18580055 1.0 24 1.0 819 30 0.8144 0.8432 84.32 0.565 1.0 3.6.1.26 PATHWAY: Phospholipid metabolism; CDP-diacylglycerol degradation; phosphatidate from CDP-diacylglycerol: step 1/1. lipid metabolism, hydrolase ProteomeLM contextual percentile 0.83; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model; matched: lipid metabolism, hydrolase /main_page_ml/ML1417 2026-05-30T13:09:52Z 9 ML0223 O69531 folE ML0223 MLCB2548.08c GTP cyclohydrolase 1 (EC 3.5.4.16) (GTP cyclohydrolase I) (GTP-CH-I) 205 83.5 High-priority 0.7143 ProteomeLM contextual shift 0.14061414 1.0 122 1.0 439 58 0.951 0.89 89.0 0.73 1.0 3.5.4.16 PATHWAY: Cofactor biosynthesis; 7,8-dihydroneopterin triphosphate biosynthesis; 7,8-dihydroneopterin triphosphate from GTP: step 1/1. folate, cofactor biosynthesis, hydrolase, cofactor ProteomeLM contextual percentile 0.71; strong pocket/AF2Bind evidence; essential-process annotation; high-confidence Boltz2 model; matched: folate, cofactor biosynthesis, hydrolase, cofactor /main_page_ml/ML0223 2026-05-30T13:09:52Z 10 ML0913 Q7AQC4 ftsW ML0913 Probable peptidoglycan glycosyltransferase FtsW (EC 2.4.99.28) (Cell division protein FtsW) (Cell wall polymerase) (Peptidoglycan polymerase) 534 83.098 High-priority 0.7444 ProteomeLM contextual shift 0.148175 1.0 152 1.0 1644 4 0.6564 0.7145 71.45 0.745 1.0 2.4.99.28 PATHWAY: Cell wall biogenesis; peptidoglycan biosynthesis. {ECO:0000256|ARBA:ARBA00004752}. cell division, fts, peptidoglycan, cell wall, transferase ProteomeLM contextual percentile 0.74; strong pocket/AF2Bind evidence; essential-process annotation; matched: cell division, fts, peptidoglycan, cell wall, transferase /main_page_ml/ML0913 2026-05-30T13:09:52Z 11 ML2474 Q9CB32 tadA ML2474 tRNA-specific adenosine deaminase (EC 3.5.4.33) 171 82.859 High-priority 0.839 ProteomeLM contextual shift 0.1966423 1.0 28 1.0 371 58 0.9663 0.8895 88.95 0.48 1.0 3.5.4.33 cofactor ProteomeLM contextual percentile 0.84; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model; matched: cofactor /main_page_ml/ML2474 2026-05-30T13:09:52Z 12 ML0519 Q9CCS3 aroQ aroD ML0519 3-dehydroquinate dehydratase (3-dehydroquinase) (EC 4.2.1.10) (Type II DHQase) 145 82.835 High-priority 0.7262 ProteomeLM contextual shift 0.14376692 1.0 284 1.0 476 82 0.9739 0.9618 96.18 0.64 1.0 4.2.1.10 PATHWAY: Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 3/7. ProteomeLM contextual percentile 0.73; strong pocket/AF2Bind evidence; essential-process annotation; high-confidence Boltz2 model /main_page_ml/ML0519 2026-05-30T13:09:52Z 13 ML1393 Q9CC23 lysX ML1393 Lysylphosphatidylglycerol biosynthesis bifunctional protein LysX [Includes: Lysine--tRNA ligase (EC 6.1.1.6) (Lysyl-tRNA synthetase) (LysRS); Phosphatidylglycerol lysyltransferase (EC 2.3.2.3) (Lysylphosphatidylglycerol synthetase) (LPG synthetase)] 1133 82.639 High-priority 0.834 ProteomeLM contextual shift 0.19098848 1.0 284 1.0 3177 0 0.4853 0.7801 78.01 0.57 0.925 2.3.2.3; 6.1.1.6 aminoacyl-trna, trna ligase, ligase, transferase, synthetase ProteomeLM contextual percentile 0.83; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model; matched: aminoacyl-trna, trna ligase, ligase, transferase, synthetase /main_page_ml/ML1393 2026-05-30T13:09:52Z 14 ML2569 Q9CD20 ML2569.1 ML2569A Putative secreted protein ML2569.1 57 82.608 High-priority 0.881 ProteomeLM contextual shift 0.26159462 1.0 52 1.0 1398 132 0.9541 0.8675 86.75 0.405 1.0 3.2.1.52 peptidoglycan, hydrolase ProteomeLM contextual percentile 0.88; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model; matched: peptidoglycan, hydrolase /main_page_ml/ML2569 2026-05-30T13:09:52Z 15 ML0230 O69524 panC ML0230 MLCB2548.01c Pantothenate synthetase (PS) (EC 6.3.2.1) (Pantoate--beta-alanine ligase) (Pantoate-activating enzyme) 313 82.505 High-priority 0.7149 ProteomeLM contextual shift 0.14078467 1.0 72 1.0 979 80 0.9346 0.8783 87.83 0.685 1.0 6.3.2.1 PATHWAY: Cofactor biosynthesis; (R)-pantothenate biosynthesis; (R)-pantothenate from (R)-pantoate and beta-alanine: step 1/1. {ECO:0000255|HAMAP-Rule:MF_00158}. cofactor biosynthesis, enzyme, ligase, synthetase ProteomeLM contextual percentile 0.71; strong pocket/AF2Bind evidence; essential-process annotation; high-confidence Boltz2 model; matched: cofactor biosynthesis, enzyme, ligase, synthetase /main_page_ml/ML0230 2026-05-30T13:09:52Z 16 ML2177 Q9CBD1 ML2177 Uridine phosphorylase (EC 2.4.2.3) 317 82.389 High-priority 0.886 ProteomeLM contextual shift 0.27713603 1.0 74 1.0 1005 108 0.9631 0.918 91.8 0.36 1.0 2.4.2.3 ProteomeLM contextual percentile 0.89; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model /main_page_ml/ML2177 2026-05-30T13:09:52Z 17 ML0006 Q57532 gyrA ML0006 DNA gyrase subunit A (EC 5.6.2.2) [Cleaved into: Mle GyrA intein] 1273 82.265 High-priority 0.8152 ProteomeLM contextual shift 0.17639826 1.0 192 1.0 1269 0 0.318 0.8084 80.84 0.615 0.835 5.6.2.2 dna gyrase, gyrase, topoisomerase, isomerase ProteomeLM contextual percentile 0.82; strong pocket/AF2Bind evidence; essential-process annotation; high-confidence Boltz2 model; matched: dna gyrase, gyrase, topoisomerase, isomerase /main_page_ml/ML0006 2026-05-30T13:09:52Z 18 ML0808 Q9CCH5 entC ML0808 isochorismate synthase (EC 5.4.4.2) (Isochorismate mutase) 577 81.949 High-priority 0.9267 ProteomeLM contextual shift 0.46599433 1.0 124 1.0 1744 26 0.9303 0.7314 73.14 0.36 1.0 5.4.4.2 synthase ProteomeLM contextual percentile 0.93; strong pocket/AF2Bind evidence; functional annotation support; matched: synthase /main_page_ml/ML0808 2026-05-30T13:09:52Z 19 ML2273 Q9CBA8 menG ML2273 Demethylmenaquinone methyltransferase (EC 2.1.1.163) 230 81.924 High-priority 0.7124 ProteomeLM contextual shift 0.14034685 1.0 26 1.0 548 144 0.9987 0.829 82.9 0.685 1.0 2.1.1.163 PATHWAY: Quinol/quinone metabolism; menaquinone biosynthesis; menaquinol from 1,4-dihydroxy-2-naphthoate: step 2/2. {ECO:0000255|HAMAP-Rule:MF_01813}. menaquinone, transferase ProteomeLM contextual percentile 0.71; strong pocket/AF2Bind evidence; essential-process annotation; high-confidence Boltz2 model; matched: menaquinone, transferase /main_page_ml/ML2273 2026-05-30T13:09:52Z 20 ML1043 P46809 hemE ML1043 Uroporphyrinogen decarboxylase (UPD) (URO-D) (EC 4.1.1.37) 357 81.867 High-priority 0.7005 ProteomeLM contextual shift 0.13674264 1.0 38 1.0 1140 138 0.9948 0.955 95.5 0.64 1.0 4.1.1.37 PATHWAY: Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 4/4. {ECO:0000255|HAMAP-Rule:MF_00218}. ProteomeLM contextual percentile 0.70; strong pocket/AF2Bind evidence; essential-process annotation; high-confidence Boltz2 model /main_page_ml/ML1043 2026-05-30T13:09:52Z 21 ML1023 Q49988 ppgK ML1023 u1764fg Polyphosphate glucokinase (EC 2.7.1.63) (ATP-dependent glucokinase) (EC 2.7.1.2) (Polyphosphate--glucose phosphotransferase) 324 81.858 High-priority 0.8446 ProteomeLM contextual shift 0.20033026 1.0 36 1.0 1004 64 0.8344 0.7697 76.97 0.48 1.0 2.7.1.2; 2.7.1.63 kinase, transferase ProteomeLM contextual percentile 0.84; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model; matched: kinase, transferase /main_page_ml/ML1023 2026-05-30T13:09:52Z 22 ML2174 Q9CBD3 cdd ML2174 Cytidine deaminase (EC 3.5.4.5) (Cytidine aminohydrolase) 134 81.828 High-priority 0.8008 ProteomeLM contextual shift 0.16938877 1.0 48 1.0 296 56 0.9595 0.9202 92.02 0.48 1.0 3.5.4.5 hydrolase, cofactor ProteomeLM contextual percentile 0.80; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model; matched: hydrolase, cofactor /main_page_ml/ML2174 2026-05-30T13:09:52Z 23 ML2359 Q9Z5K4 tesA ML2359 MLCB12.04c Thioesterase TesA (EC 3.1.2.-) 261 81.716 High-priority 0.8377 ProteomeLM contextual shift 0.19516578 1.0 30 1.0 845 124 0.9881 0.7796 77.96 0.48 1.0 3.1.2.- hydrolase ProteomeLM contextual percentile 0.84; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model; matched: hydrolase /main_page_ml/ML2359 2026-05-30T13:09:52Z 24 ML0231 Q9CD57 panD ML0231 Aspartate 1-decarboxylase (EC 4.1.1.11) (Aspartate alpha-decarboxylase) [Cleaved into: Aspartate 1-decarboxylase beta chain; Aspartate 1-decarboxylase alpha chain] 142 81.709 High-priority 0.6917 ProteomeLM contextual shift 0.13306487 1.0 56 1.0 442 32 0.9326 0.8798 87.98 0.685 1.0 4.1.1.11 PATHWAY: Cofactor biosynthesis; (R)-pantothenate biosynthesis; beta-alanine from L-aspartate: step 1/1. {ECO:0000255|HAMAP-Rule:MF_00446}. cofactor biosynthesis, cofactor ProteomeLM contextual percentile 0.69; strong pocket/AF2Bind evidence; essential-process annotation; high-confidence Boltz2 model; matched: cofactor biosynthesis, cofactor /main_page_ml/ML0231 2026-05-30T13:09:52Z 25 ML0697 Q9CCM1 sdhA ML0697 Succinate dehydrogenase flavoprotein subunit (EC 1.3.5.1) 584 81.686 High-priority 0.7043 ProteomeLM contextual shift 0.13755086 1.0 64 1.0 1795 86 0.9347 0.9237 92.37 0.64 1.0 1.3.5.1 PATHWAY: Carbohydrate metabolism; tricarboxylic acid cycle; fumarate from succinate (bacterial route): step 1/1. {ECO:0000256|ARBA:ARBA00004894, ECO:0000256|RuleBase:RU362051}. oxidoreductase, dehydrogenase, reductase ProteomeLM contextual percentile 0.70; strong pocket/AF2Bind evidence; essential-process annotation; high-confidence Boltz2 model; matched: oxidoreductase, dehydrogenase, reductase /main_page_ml/ML0697 2026-05-30T13:09:52Z 26 ML1993 Q9CBG3 ML1993 (2E)-enoyl-[ACP] glycyltransferase (EC 4.3.2.11) ((2E)-unsaturated fatty acyl-[ACP] glycyltransferase) 183 81.523 High-priority 0.864 ProteomeLM contextual shift 0.22656678 1.0 44 1.0 573 8 0.5849 0.9082 90.82 0.36 1.0 4.3.2.11 transferase, lyase ProteomeLM contextual percentile 0.86; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model; matched: transferase, lyase /main_page_ml/ML1993 2026-05-30T13:09:52Z 27 ML1663 O69466 coaD kdtB ML1663 MLCB1243.10 Phosphopantetheine adenylyltransferase (EC 2.7.7.3) (Dephospho-CoA pyrophosphorylase) (Pantetheine-phosphate adenylyltransferase) (PPAT) 160 81.365 High-priority 0.6779 ProteomeLM contextual shift 0.13050112 1.0 118 1.0 522 102 0.9745 0.8937 89.37 0.685 1.0 2.7.7.3 PATHWAY: Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 4/5. {ECO:0000255|HAMAP-Rule:MF_00151}. cofactor biosynthesis, enzyme, transferase, cofactor ProteomeLM contextual percentile 0.68; strong pocket/AF2Bind evidence; essential-process annotation; high-confidence Boltz2 model; matched: cofactor biosynthesis, enzyme, transferase, cofactor /main_page_ml/ML1663 2026-05-30T13:09:52Z 28 ML0424 Q7AQJ4 bcp ML0424 thioredoxin-dependent peroxiredoxin (EC 1.11.1.24) (Bacterioferritin comigratory protein) (Thioredoxin peroxidase) 161 81.33 High-priority 0.787 ProteomeLM contextual shift 0.16389123 1.0 10 1.0 489 12 0.7782 0.9186 91.86 0.48 1.0 1.11.1.24 ProteomeLM contextual percentile 0.79; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model /main_page_ml/ML0424 2026-05-30T13:09:52Z 29 ML1130 P45837 thrC ML1130 Threonine synthase (TS) (EC 4.2.3.1) 360 81.326 High-priority 0.6949 ProteomeLM contextual shift 0.13557072 1.0 76 1.0 1132 104 0.9362 0.9205 92.05 0.64 1.0 4.2.3.1 PATHWAY: Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 5/5. lyase, synthase, cofactor ProteomeLM contextual percentile 0.69; strong pocket/AF2Bind evidence; essential-process annotation; high-confidence Boltz2 model; matched: lyase, synthase, cofactor /main_page_ml/ML1130 2026-05-30T13:09:52Z 30 ML2441 P53531 gpmA gpm pgm ML2441 B2168_C3_246 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase (BPG-dependent PGAM) (PGAM) (Phosphoglyceromutase) (dPGM) (EC 5.4.2.11) 247 81.291 High-priority 0.688 ProteomeLM contextual shift 0.13202992 1.0 50 1.0 762 42 0.8938 0.9412 94.12 0.64 1.0 5.4.2.11 PATHWAY: Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 3/5. {ECO:0000255|HAMAP-Rule:MF_01039}. ProteomeLM contextual percentile 0.69; strong pocket/AF2Bind evidence; essential-process annotation; high-confidence Boltz2 model /main_page_ml/ML2441 2026-05-30T13:09:52Z 31 ML0322 Q9CCW5 ispF ML0322 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase (MECDP-synthase) (MECPP-synthase) (MECPS) (EC 4.6.1.12) 158 81.256 High-priority 0.6629 ProteomeLM contextual shift 0.12794426 1.0 40 1.0 519 90 0.9431 0.9354 93.54 0.685 1.0 4.6.1.12 PATHWAY: Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 4/6. {ECO:0000255|HAMAP-Rule:MF_00107}. isoprenoid, synthase, cofactor ProteomeLM contextual percentile 0.66; strong pocket/AF2Bind evidence; essential-process annotation; high-confidence Boltz2 model; matched: isoprenoid, synthase, cofactor /main_page_ml/ML0322 2026-05-30T13:09:52Z 32 ML1006 Q9CCB8 ML1006 Peroxynitrite isomerase (EC 5.99.-.-) (Ferric nitrobindin) (Nb(III)) 161 81.236 High-priority 0.6867 ProteomeLM contextual shift 0.13148868 1.0 16 1.0 540 114 0.9762 0.94 94.0 0.64 1.0 5.99.-.- PATHWAY: Nitrogen metabolism. {ECO:0000255|HAMAP-Rule:MF_01297}. isomerase, cofactor ProteomeLM contextual percentile 0.69; strong pocket/AF2Bind evidence; essential-process annotation; high-confidence Boltz2 model; matched: isomerase, cofactor /main_page_ml/ML1006 2026-05-30T13:09:52Z 33 ML0979 Q7AQC0 ML0979 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase (EC 2.7.8.5) 193 81.108 High-priority 0.8252 ProteomeLM contextual shift 0.18456998 1.0 48 1.0 644 130 0.9852 0.8326 83.26 0.445 1.0 2.7.8.5 PATHWAY: Lipid metabolism; phospholipid metabolism. {ECO:0000256|ARBA:ARBA00005074}. lipid metabolism, transferase ProteomeLM contextual percentile 0.83; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model; matched: lipid metabolism, transferase /main_page_ml/ML0979 2026-05-30T13:09:52Z 34 ML1272 Q9CC54 trpB ML1272 Tryptophan synthase beta chain (EC 4.2.1.20) 417 81.069 High-priority 0.7462 ProteomeLM contextual shift 0.14867157 1.0 124 1.0 1312 122 0.9713 0.955 95.5 0.52 1.0 4.2.1.20 PATHWAY: Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 5/5. synthase, cofactor ProteomeLM contextual percentile 0.75; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model; matched: synthase, cofactor /main_page_ml/ML1272 2026-05-30T13:09:52Z 35 ML0226 O69528 folK ML0226 MLCB2548.05c 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase (EC 2.7.6.3) (6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase) (PPPK) (7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase) (HPPK) 191 81.034 High-priority 0.7231 ProteomeLM contextual shift 0.14320546 1.0 26 1.0 404 44 0.8714 0.8527 85.27 0.61 1.0 2.7.6.3 PATHWAY: Cofactor biosynthesis; tetrahydrofolate biosynthesis; 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 7,8-dihydroneopterin triphosphate: step 4/4. {ECO:0000250|UniProtKB:P26281}. folate, cofactor biosynthesis, kinase, cofactor ProteomeLM contextual percentile 0.72; strong pocket/AF2Bind evidence; essential-process annotation; high-confidence Boltz2 model; matched: folate, cofactor biosynthesis, kinase, cofactor /main_page_ml/ML0226 2026-05-30T13:09:52Z 36 ML1961 Q9X7A2 rpmJ ML1961 MLCB1222.31c Large ribosomal subunit protein bL36 (50S ribosomal protein L36) 37 80.9 High-priority 0.9912 ProteomeLM contextual shift 0.984493 1.0 8 1.0 171 0 0.4739 0.9332 93.32 0.215 0.7575 translation, ribosome, ribosomal ProteomeLM contextual percentile 0.99; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: translation, ribosome, ribosomal /main_page_ml/ML1961 2026-05-30T13:09:52Z 37 ML0011 Q9CDE9 ppiA ML0011 Probable peptidyl-prolyl cis-trans isomerase A (PPIase A) (EC 5.2.1.8) (Rotamase A) 182 80.78 High-priority 0.8383 ProteomeLM contextual shift 0.19563217 1.0 26 1.0 394 60 0.9757 0.9238 92.38 0.36 1.0 5.2.1.8 isomerase ProteomeLM contextual percentile 0.84; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model; matched: isomerase /main_page_ml/ML0011 2026-05-30T13:09:52Z 38 ML0859 O32961 lipB ML0859 MLCB22.19 Octanoyltransferase (EC 2.3.1.181) (Lipoate-protein ligase B) (Lipoyl/octanoyl transferase) (Octanoyl-[acyl-carrier-protein]-protein N-octanoyltransferase) 235 80.641 High-priority 0.6842 ProteomeLM contextual shift 0.13106775 1.0 42 1.0 520 100 0.9724 0.8893 88.93 0.64 1.0 2.3.1.181 PATHWAY: Protein modification; protein lipoylation via endogenous pathway; protein N(6)-(lipoyl)lysine from octanoyl-[acyl-carrier-protein]: step 1/2. {ECO:0000255|HAMAP-Rule:MF_00013}. ligase, transferase ProteomeLM contextual percentile 0.68; strong pocket/AF2Bind evidence; essential-process annotation; high-confidence Boltz2 model; matched: ligase, transferase /main_page_ml/ML0859 2026-05-30T13:09:52Z 39 ML0628 Q49752 ybeY ML0628 B1937_F1_21 Endoribonuclease YbeY (EC 3.1.-.-) 178 80.229 High-priority 0.8503 ProteomeLM contextual shift 0.20915979 1.0 20 1.0 544 20 0.8894 0.827 82.7 0.36 1.0 3.1.-.- cofactor ProteomeLM contextual percentile 0.85; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model; matched: cofactor /main_page_ml/ML0628 2026-05-30T13:09:52Z 40 ML2219 O05755 ML2219.1 ML2219A MLCB5.24 Phosphoribosylformylglycinamidine synthase subunit PurS (FGAM synthase) (EC 6.3.5.3) (Formylglycinamide ribonucleotide amidotransferase subunit III) (FGAR amidotransferase III) (FGAR-AT III) (Phosphoribosylformylglycinamidine synthase subunit III) 79 80.194 High-priority 0.6667 ProteomeLM contextual shift 0.12863974 1.0 59 1.0 933 48 0.8812 0.9061 90.61 0.64 1.0 3.5.1.2; 6.3.5.3 PATHWAY: Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 1/2. {ECO:0000255|HAMAP-Rule:MF_00421}. transferase, synthase ProteomeLM contextual percentile 0.67; strong pocket/AF2Bind evidence; essential-process annotation; high-confidence Boltz2 model; matched: transferase, synthase /main_page_ml/ML2219 2026-05-30T13:09:52Z 41 ML2647 Q9CCZ3 msrA ML2647 Peptide methionine sulfoxide reductase MsrA (Protein-methionine-S-oxide reductase) (EC 1.8.4.11) (Peptide-methionine (S)-S-oxide reductase) (Peptide Met(O) reductase) 177 80.129 High-priority 0.7556 ProteomeLM contextual shift 0.15111956 1.0 18 1.0 537 12 0.6977 0.9082 90.82 0.48 1.0 1.8.4.11 oxidoreductase, reductase ProteomeLM contextual percentile 0.76; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model; matched: oxidoreductase, reductase /main_page_ml/ML2647 2026-05-30T13:09:52Z 42 ML0224 P0C0X1 folP1 folP ML0224 MLCB2548.07c Dihydropteroate synthase (DHPS) (EC 2.5.1.15) (Dihydropteroate pyrophosphorylase) 284 80.062 High-priority 0.6159 ProteomeLM contextual shift 0.11928336 1.0 80 1.0 903 102 0.9638 0.8905 89.05 0.73 1.0 2.5.1.15 PATHWAY: Cofactor biosynthesis; tetrahydrofolate biosynthesis; 7,8-dihydrofolate from 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate and 4-aminobenzoate: step 1/2. {ECO:0000305|PubMed:10542185}. folate, cofactor biosynthesis, synthase, cofactor ProteomeLM contextual percentile 0.62; strong pocket/AF2Bind evidence; essential-process annotation; high-confidence Boltz2 model; matched: folate, cofactor biosynthesis, synthase, cofactor /main_page_ml/ML0224 2026-05-30T13:09:52Z 43 ML1925 Q9CBI6 sodC ML1925 Superoxide dismutase [Cu-Zn] (EC 1.15.1.1) 240 80.054 High-priority 0.7995 ProteomeLM contextual shift 0.16930966 1.0 64 1.0 733 26 0.8384 0.7472 74.72 0.48 1.0 1.15.1.1 cofactor ProteomeLM contextual percentile 0.80; strong pocket/AF2Bind evidence; functional annotation support; matched: cofactor /main_page_ml/ML1925 2026-05-30T13:09:52Z 44 ML1309 Q49786 hisE ML1309 B2126_C2_204 MLCB2533.06 Phosphoribosyl-ATP pyrophosphatase (PRA-PH) (EC 3.6.1.31) 93 80.021 High-priority 0.7575 ProteomeLM contextual shift 0.15214595 1.0 20 1.0 321 84 0.9559 0.9158 91.58 0.52 0.895 3.6.1.31 PATHWAY: Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 2/9. ProteomeLM contextual percentile 0.76; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model /main_page_ml/ML1309 2026-05-30T13:09:52Z 45 ML1409 Q9CC12 argD ML1409 Acetylornithine aminotransferase (ACOAT) (EC 2.6.1.11) 404 79.926 Strong candidate 0.6435 ProteomeLM contextual shift 0.12384868 1.0 82 1.0 1277 130 0.983 0.9604 96.04 0.64 1.0 2.6.1.11 PATHWAY: Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 4/4. {ECO:0000255|HAMAP-Rule:MF_01107}. transferase, cofactor ProteomeLM contextual percentile 0.64; strong pocket/AF2Bind evidence; essential-process annotation; high-confidence Boltz2 model; matched: transferase, cofactor /main_page_ml/ML1409 2026-05-30T13:09:52Z 46 ML0751 Q9CCK8 rmlD ML0751 dTDP-4-dehydrorhamnose reductase (EC 1.1.1.133) 311 79.858 Strong candidate 0.7882 ProteomeLM contextual shift 0.16430841 1.0 48 1.0 998 130 0.9376 0.927 92.7 0.4 1.0 1.1.1.133 PATHWAY: Carbohydrate biosynthesis; dTDP-L-rhamnose biosynthesis. {ECO:0000256|RuleBase:RU364082}. reductase ProteomeLM contextual percentile 0.79; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model; matched: reductase /main_page_ml/ML0751 2026-05-30T13:09:52Z 47 ML0454 Q7AQI9 pgsA ML0454 Phosphatidylinositol phosphate synthase (PIP synthase) (EC 2.7.8.-) (CDP-diacylglycerol--D-myo-inositol-3-phosphate 3-phosphatidyltransferase) 239 79.83 Strong candidate 0.6497 ProteomeLM contextual shift 0.12475294 1.0 54 1.0 741 48 0.8281 0.8389 83.89 0.685 1.0 2.7.8.- PATHWAY: Lipid metabolism. {ECO:0000256|ARBA:ARBA00005189}.; PATHWAY: Phospholipid metabolism; phosphatidylinositol phosphate biosynthesis. {ECO:0000256|ARBA:ARBA00004805, ECO:0000256|HAMAP-Rule:MF_02241}. lipid metabolism, transferase, synthase, cofactor ProteomeLM contextual percentile 0.65; strong pocket/AF2Bind evidence; essential-process annotation; high-confidence Boltz2 model; matched: lipid metabolism, transferase, synthase, cofactor /main_page_ml/ML0454 2026-05-30T13:09:52Z 48 ML1656 O69473 kasB ML1656 MLCB1243.19c 3-oxoacyl-[acyl-carrier-protein] synthase 2 (EC 2.3.1.294) (Beta-ketoacyl-ACP synthase 2) (KAS 2) 420 79.816 Strong candidate 0.5927 ProteomeLM contextual shift 0.11641096 1.0 90 1.0 1333 116 0.9786 0.9471 94.71 0.73 1.0 2.3.1.294 PATHWAY: Lipid metabolism; mycolic acid biosynthesis. {ECO:0000250|UniProtKB:P9WQD7}. mycolic, lipid metabolism, synthase ProteomeLM contextual percentile 0.59; strong pocket/AF2Bind evidence; essential-process annotation; high-confidence Boltz2 model; matched: mycolic, lipid metabolism, synthase /main_page_ml/ML1656 2026-05-30T13:09:52Z 49 ML2206 Q50028 purF ML2206 MLCB5.38 Amidophosphoribosyltransferase (ATase) (EC 2.4.2.14) (Glutamine phosphoribosylpyrophosphate amidotransferase) (GPATase) 556 79.649 Strong candidate 0.6817 ProteomeLM contextual shift 0.1308002 1.0 204 1.0 1693 10 0.6647 0.7989 79.89 0.64 1.0 2.4.2.14 PATHWAY: Purine metabolism; IMP biosynthesis via de novo pathway; N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/2. {ECO:0000255|HAMAP-Rule:MF_01931}. transferase, cofactor ProteomeLM contextual percentile 0.68; strong pocket/AF2Bind evidence; essential-process annotation; high-confidence Boltz2 model; matched: transferase, cofactor /main_page_ml/ML2206 2026-05-30T13:09:52Z 50 ML1484 Q9CBY1 rpiB ML1484 Ribose-5-phosphate isomerase B (EC 5.3.1.6) (Phosphoriboisomerase B) 162 79.639 Strong candidate 0.6347 ProteomeLM contextual shift 0.12220789 1.0 32 1.0 519 66 0.9201 0.9624 96.24 0.64 1.0 5.3.1.6 PATHWAY: Carbohydrate degradation; pentose phosphate pathway; D-ribose 5-phosphate from D-ribulose 5-phosphate (non-oxidative stage): step 1/1. {ECO:0000250|UniProtKB:P9WKD7}. isomerase ProteomeLM contextual percentile 0.63; strong pocket/AF2Bind evidence; essential-process annotation; high-confidence Boltz2 model; matched: isomerase /main_page_ml/ML1484 2026-05-30T13:09:52Z 51 ML2708 Q50203 rsmG gidB ML2708 Ribosomal RNA small subunit methyltransferase G (EC 2.1.1.-) (16S rRNA 7-methylguanosine methyltransferase) (16S rRNA m7G methyltransferase) (Glucose-inhibited division protein B) 245 79.268 Strong candidate 0.7895 ProteomeLM contextual shift 0.16514271 1.0 32 1.0 516 40 0.9331 0.8537 85.37 0.405 1.0 2.1.1.- ribosomal, transferase ProteomeLM contextual percentile 0.79; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model; matched: ribosomal, transferase /main_page_ml/ML2708 2026-05-30T13:09:52Z 52 ML0414 Q49734 otsB ML0414 MLCL383.17c Trehalose-phosphate phosphatase (TPP) (EC 3.1.3.12) (Trehalose-6-phosphate phosphatase) 429 79.196 Strong candidate 0.6472 ProteomeLM contextual shift 0.12435981 1.0 70 1.0 889 62 0.8275 0.8742 87.42 0.64 1.0 3.1.3.12 PATHWAY: Glycan biosynthesis; trehalose biosynthesis. cofactor ProteomeLM contextual percentile 0.65; strong pocket/AF2Bind evidence; essential-process annotation; high-confidence Boltz2 model; matched: cofactor /main_page_ml/ML0414 2026-05-30T13:09:52Z 53 ML0133 Q9CD83 ML0133 Chorismate pyruvate-lyase (EC 4.1.3.40) (4-HB synthase) (p-hydroxybenzoic acid synthase) 210 79.071 Strong candidate 0.8258 ProteomeLM contextual shift 0.18478276 1.0 40 1.0 651 42 0.793 0.7968 79.68 0.36 1.0 4.1.3.40 lyase, synthase ProteomeLM contextual percentile 0.83; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model; matched: lyase, synthase /main_page_ml/ML0133 2026-05-30T13:09:52Z 54 ML2570 Q9CD19 ML2570 Alpha-(1->3)-arabinofuranosyltransferase (EC 2.4.2.47) (Arabinofuranan 3-O-arabinosyltransferase) 1405 79.064 Strong candidate 0.7168 ProteomeLM contextual shift 0.14123528 1.0 303 1.0 1425 0 0.3496 0.9326 93.26 0.565 0.835 2.4.2.47 PATHWAY: Cell wall biogenesis; cell wall polysaccharide biosynthesis. {ECO:0000256|ARBA:ARBA00004776}. cell wall, transferase ProteomeLM contextual percentile 0.72; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model; matched: cell wall, transferase /main_page_ml/ML2570 2026-05-30T13:09:52Z 55 ML1941 Q9X784 xseB ML1941 MLCB1222.09 Exodeoxyribonuclease 7 small subunit (EC 3.1.11.6) (Exodeoxyribonuclease VII small subunit) (Exonuclease VII small subunit) 78 79.03 Strong candidate 0.8634 ProteomeLM contextual shift 0.22500767 1.0 8 1.0 304 6 0.6824 0.7661 76.61 0.36 0.895 3.1.11.6 ProteomeLM contextual percentile 0.86; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model /main_page_ml/ML1941 2026-05-30T13:09:52Z 56 ML1679 Q9CBR9 gpsA ML1679 MLCB637.38 Glycerol-3-phosphate dehydrogenase [NAD(P)+] (EC 1.1.1.94) (NAD(P)(+)-dependent glycerol-3-phosphate dehydrogenase) (NAD(P)H-dependent dihydroxyacetone-phosphate reductase) 349 79.023 Strong candidate 0.589 ProteomeLM contextual shift 0.11596433 1.0 62 1.0 1123 140 0.9739 0.8809 88.09 0.73 1.0 1.1.1.94 PATHWAY: Membrane lipid metabolism; glycerophospholipid metabolism. {ECO:0000255|HAMAP-Rule:MF_00394}. nad, lipid metabolism, dehydrogenase, reductase ProteomeLM contextual percentile 0.59; strong pocket/AF2Bind evidence; essential-process annotation; high-confidence Boltz2 model; matched: nad, lipid metabolism, dehydrogenase, reductase /main_page_ml/ML1679 2026-05-30T13:09:52Z 57 ML1987 P46839 ctpA ML1987 Copper-exporting P-type ATPase (EC 7.2.2.8) (Copper-exporting P-type ATPase A) 780 78.98 Strong candidate 0.8095 ProteomeLM contextual shift 0.17279348 1.0 148 1.0 1553 2 0.5222 0.6797 67.97 0.48 0.925 7.2.2.8 ProteomeLM contextual percentile 0.81; strong pocket/AF2Bind evidence; functional annotation support /main_page_ml/ML1987 2026-05-30T13:09:52Z 58 ML1546 Q9Z5I4 truB ML1546 MLCB596.24 tRNA pseudouridine synthase B (EC 5.4.99.25) (tRNA pseudouridine(55) synthase) (Psi55 synthase) (tRNA pseudouridylate synthase) (tRNA-uridine isomerase) 320 78.672 Strong candidate 0.7237 ProteomeLM contextual shift 0.14323679 1.0 33 1.0 652 24 0.8829 0.8743 87.43 0.48 1.0 5.4.99.25 isomerase, synthase ProteomeLM contextual percentile 0.72; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model; matched: isomerase, synthase /main_page_ml/ML1546 2026-05-30T13:09:52Z 59 ML0541 Q9CCQ7 gmk ML0541 Guanylate kinase (EC 2.7.4.8) (GMP kinase) 210 78.597 Strong candidate 0.7337 ProteomeLM contextual shift 0.14552139 1.0 33 1.0 667 74 0.968 0.8317 83.17 0.48 1.0 2.7.4.8 kinase ProteomeLM contextual percentile 0.73; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model; matched: kinase /main_page_ml/ML0541 2026-05-30T13:09:52Z 60 ML2414 P46716 hemL gsa ML2414 B2168_C1_190 Glutamate-1-semialdehyde 2,1-aminomutase (GSA) (EC 5.4.3.8) (Glutamate-1-semialdehyde aminotransferase) (GSA-AT) 446 78.582 Strong candidate 0.6905 ProteomeLM contextual shift 0.1328579 1.0 86 1.0 1415 154 0.962 0.9015 90.15 0.52 1.0 5.4.3.8 PATHWAY: Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; 5-aminolevulinate from L-glutamyl-tRNA(Glu): step 2/2. transferase, cofactor ProteomeLM contextual percentile 0.69; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model; matched: transferase, cofactor /main_page_ml/ML2414 2026-05-30T13:09:52Z 61 ML0874 Q9CCF2 asnB ML0874 asparagine synthase (glutamine-hydrolyzing) (EC 6.3.5.4) 677 78.487 Strong candidate 0.6241 ProteomeLM contextual shift 0.120814644 1.0 106 1.0 2036 10 0.718 0.8845 88.45 0.64 1.0 6.3.5.4 PATHWAY: Amino-acid biosynthesis; L-asparagine biosynthesis; L-asparagine from L-aspartate (L-Gln route): step 1/1. {ECO:0000256|ARBA:ARBA00005187}. synthetase, synthase ProteomeLM contextual percentile 0.62; strong pocket/AF2Bind evidence; essential-process annotation; high-confidence Boltz2 model; matched: synthetase, synthase /main_page_ml/ML0874 2026-05-30T13:09:52Z 62 ML0299 Q7AQJ9 ML0299 glycine oxidase (EC 1.4.3.19) 340 78.429 Strong candidate 0.6535 ProteomeLM contextual shift 0.12589404 1.0 58 1.0 1047 54 0.8887 0.9256 92.56 0.565 1.0 1.4.3.19 PATHWAY: Cofactor biosynthesis; thiamine diphosphate biosynthesis. {ECO:0000256|ARBA:ARBA00004948}. cofactor biosynthesis, cofactor ProteomeLM contextual percentile 0.65; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model; matched: cofactor biosynthesis, cofactor /main_page_ml/ML0299 2026-05-30T13:09:52Z 63 ML0560 Q9CCP3 ribH ML0560 6,7-dimethyl-8-ribityllumazine synthase (DMRL synthase) (LS) (Lumazine synthase) (EC 2.5.1.78) 160 78.228 Strong candidate 0.584 ProteomeLM contextual shift 0.11505175 1.0 54 1.0 521 82 0.937 0.909 90.9 0.685 1.0 2.5.1.78 PATHWAY: Cofactor biosynthesis; riboflavin biosynthesis; riboflavin from 2-hydroxy-3-oxobutyl phosphate and 5-amino-6-(D-ribitylamino)uracil: step 1/2. {ECO:0000255|HAMAP-Rule:MF_00178}. cofactor biosynthesis, synthase, cofactor ProteomeLM contextual percentile 0.58; strong pocket/AF2Bind evidence; essential-process annotation; high-confidence Boltz2 model; matched: cofactor biosynthesis, synthase, cofactor /main_page_ml/ML0560 2026-05-30T13:09:52Z 64 ML1135 P45832 prmC hemK ML1135 Release factor glutamine methyltransferase (RF MTase) (EC 2.1.1.297) (M.MleHemKP) (N5-glutamine methyltransferase PrmC) (Protein-(glutamine-N5) MTase PrmC) (Protein-glutamine N-methyltransferase PrmC) 288 78.085 Strong candidate 0.6855 ProteomeLM contextual shift 0.1311837 1.0 54 1.0 902 76 0.9461 0.9493 94.93 0.48 1.0 2.1.1.297 transferase ProteomeLM contextual percentile 0.69; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model; matched: transferase /main_page_ml/ML1135 2026-05-30T13:09:52Z 65 ML0906 O69560 rsmH mraW ML0906 MLCB268.10c Ribosomal RNA small subunit methyltransferase H (EC 2.1.1.199) (16S rRNA m(4)C1402 methyltransferase) (rRNA (cytosine-N(4)-)-methyltransferase RsmH) 372 78.066 Strong candidate 0.6992 ProteomeLM contextual shift 0.13620017 1.0 40 1.0 1158 84 0.8865 0.8092 80.92 0.525 1.0 2.1.1.199 ribosomal, transferase ProteomeLM contextual percentile 0.70; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model; matched: ribosomal, transferase /main_page_ml/ML0906 2026-05-30T13:09:52Z 66 ML0173 Q9CD69 rpmF ML0173 Large ribosomal subunit protein bL32 (50S ribosomal protein L32) 57 77.924 Strong candidate 0.9787 ProteomeLM contextual shift 0.76864207 1.0 8 1.0 192 42 0.8204 0.6795 67.95 0.215 0.7575 translation, ribosome, ribosomal ProteomeLM contextual percentile 0.98; strong pocket/AF2Bind evidence; matched: translation, ribosome, ribosomal /main_page_ml/ML0173 2026-05-30T13:09:52Z 67 ML0241 Q9CD52 rsmA ksgA ML0241 Ribosomal RNA small subunit methyltransferase A (EC 2.1.1.182) (16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase) (16S rRNA dimethyladenosine transferase) (16S rRNA dimethylase) (S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase) 306 77.908 Strong candidate 0.6717 ProteomeLM contextual shift 0.129576 1.0 42 1.0 924 12 0.5936 0.8899 88.99 0.525 1.0 2.1.1.182 ribosomal, transferase ProteomeLM contextual percentile 0.67; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model; matched: ribosomal, transferase /main_page_ml/ML0241 2026-05-30T13:09:52Z 68 ML0842 O32975 cyd csd1 ML0842 MLCB22.44c Probable cysteine desulfurase 1 (EC 2.8.1.7) 611 77.903 Strong candidate 0.6805 ProteomeLM contextual shift 0.13077499 1.0 83 1.0 1244 22 0.88 0.9488 94.88 0.48 1.0 2.8.1.7 transferase, cofactor ProteomeLM contextual percentile 0.68; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model; matched: transferase, cofactor /main_page_ml/ML0842 2026-05-30T13:09:52Z 69 ML1261 Q9CC56 priA hisA ML1261 MLCB1610.24 Phosphoribosyl isomerase A (1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase) (EC 5.3.1.16) (N-(5'-phosphoribosyl)anthranilate isomerase) (PRAI) (EC 5.3.1.24) (Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase) 244 77.834 Strong candidate 0.5921 ProteomeLM contextual shift 0.116194405 1.0 29 1.0 819 168 0.9954 0.9311 93.11 0.64 1.0 5.3.1.16; 5.3.1.24 PATHWAY: Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 4/9.; PATHWAY: Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 3/5. isomerase ProteomeLM contextual percentile 0.59; strong pocket/AF2Bind evidence; essential-process annotation; high-confidence Boltz2 model; matched: isomerase /main_page_ml/ML1261 2026-05-30T13:09:52Z 70 ML1615 O33017 trmD ML1615 MLCB250.35 tRNA (guanine-N(1)-)-methyltransferase (EC 2.1.1.228) (M1G-methyltransferase) (tRNA [GM37] methyltransferase) 238 77.795 Strong candidate 0.6924 ProteomeLM contextual shift 0.1332519 1.0 54 1.0 727 26 0.7681 0.8962 89.62 0.48 1.0 2.1.1.228 transferase ProteomeLM contextual percentile 0.69; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model; matched: transferase /main_page_ml/ML1615 2026-05-30T13:09:52Z 71 ML1259 Q9X7B9 hisB ML1259 MLCB1610.22 Imidazoleglycerol-phosphate dehydratase (IGPD) (EC 4.2.1.19) 210 77.772 Strong candidate 0.666 ProteomeLM contextual shift 0.12853438 1.0 307 1.0 690 0 0.3709 0.9061 90.61 0.52 1.0 4.2.1.19 PATHWAY: Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 6/9. {ECO:0000255|HAMAP-Rule:MF_00076}. ProteomeLM contextual percentile 0.67; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model /main_page_ml/ML1259 2026-05-30T13:09:52Z 72 ML0839 O32978 cysK ML0839 MLCB22.47 O-acetylserine sulfhydrylase (OAS sulfhydrylase) (OASS) (EC 2.5.1.47) (Cysteine synthase A) (CSase A) (O-acetylserine (thiol)-lyase A) (OAS-TL A) (O-acetylserine-specific cysteine synthase) (Sulfide-dependent cysteine synthase) 310 77.756 Strong candidate 0.5833 ProteomeLM contextual shift 0.114882305 1.0 72 1.0 1002 144 0.9802 0.954 95.4 0.64 1.0 2.5.1.47 PATHWAY: Amino-acid biosynthesis; L-cysteine biosynthesis; L-cysteine from L-serine: step 2/2. lyase, synthase, cofactor ProteomeLM contextual percentile 0.58; strong pocket/AF2Bind evidence; essential-process annotation; high-confidence Boltz2 model; matched: lyase, synthase, cofactor /main_page_ml/ML0839 2026-05-30T13:09:52Z 73 ML0909 O69557 murE ML0909 MLCB268.07c UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase (EC 6.3.2.13) (Meso-A2pm-adding enzyme) (Meso-diaminopimelate-adding enzyme) (UDP-MurNAc-L-Ala-D-Glu:meso-diaminopimelate ligase) (UDP-MurNAc-tripeptide synthetase) (UDP-N-acetylmuramyl-tripeptide synthetase) 530 77.723 Strong candidate 0.5063 ProteomeLM contextual shift 0.103578694 1.0 52 1.0 1622 64 0.9317 0.8604 86.04 0.82 1.0 6.3.2.13 PATHWAY: Cell wall biogenesis; peptidoglycan biosynthesis. {ECO:0000255|HAMAP-Rule:MF_00208}. cell division, peptidoglycan, cell wall, mur, enzyme, ligase, synthetase ProteomeLM contextual percentile 0.51; strong pocket/AF2Bind evidence; essential-process annotation; high-confidence Boltz2 model; matched: cell division, peptidoglycan, cell wall, mur, enzyme /main_page_ml/ML0909 2026-05-30T13:09:52Z 74 ML1846 O32996 rpsZ rpsN ML1846 MLCB2492.17 Small ribosomal subunit protein uS14 (30S ribosomal protein S14 type Z) 61 77.676 Strong candidate 0.8615 ProteomeLM contextual shift 0.22256047 1.0 8 1.0 198 30 0.8645 0.6873 68.73 0.335 0.895 translation, ribosome, ribosomal, cofactor ProteomeLM contextual percentile 0.86; strong pocket/AF2Bind evidence; matched: translation, ribosome, ribosomal, cofactor /main_page_ml/ML1846 2026-05-30T13:09:52Z 75 ML1218 P45486 bioD ML1218 B1170_C1_159 ATP-dependent dethiobiotin synthetase BioD (EC 6.3.3.3) (DTB synthetase) (DTBS) (Dethiobiotin synthase) 226 77.609 Strong candidate 0.5508 ProteomeLM contextual shift 0.109361045 1.0 36 1.0 706 56 0.9106 0.9632 96.32 0.685 1.0 6.3.3.3 PATHWAY: Cofactor biosynthesis; biotin biosynthesis; biotin from 7,8-diaminononanoate: step 1/2. {ECO:0000255|HAMAP-Rule:MF_00336}. cofactor biosynthesis, synthetase, synthase, cofactor ProteomeLM contextual percentile 0.55; strong pocket/AF2Bind evidence; essential-process annotation; high-confidence Boltz2 model; matched: cofactor biosynthesis, synthetase, synthase, cofactor /main_page_ml/ML1218 2026-05-30T13:09:52Z 76 ML1601 Q7AQ39 ML1601 Carbamoyltransferase domain-containing protein 121 77.526 Strong candidate 0.9937 ProteomeLM contextual shift 1.0237005 1.0 28 1.0 457 188 0.9893 0.6146 61.46 0.08 1.0 transferase ProteomeLM contextual percentile 0.99; strong pocket/AF2Bind evidence; matched: transferase /main_page_ml/ML1601 2026-05-30T13:09:52Z 77 ML0474 Q9CCT5 pdxT ML0474 Pyridoxal 5'-phosphate synthase subunit PdxT (EC 4.3.3.6) (Pdx2) (Pyridoxal 5'-phosphate synthase glutaminase subunit) (EC 3.5.1.2) 198 77.47 Strong candidate 0.5702 ProteomeLM contextual shift 0.11217498 1.0 22 1.0 449 6 0.648 0.8814 88.14 0.685 1.0 3.5.1.2; 4.3.3.6 PATHWAY: Cofactor biosynthesis; pyridoxal 5'-phosphate biosynthesis. {ECO:0000255|HAMAP-Rule:MF_01615}. cofactor biosynthesis, synthase, cofactor ProteomeLM contextual percentile 0.57; strong pocket/AF2Bind evidence; essential-process annotation; high-confidence Boltz2 model; matched: cofactor biosynthesis, synthase, cofactor /main_page_ml/ML0474 2026-05-30T13:09:52Z 78 ML1321 Q9ZBE0 pup ML1321 MLCB2533.18 Prokaryotic ubiquitin-like protein Pup (Bacterial ubiquitin-like modifier) 63 77.448 Strong candidate 0.9549 ProteomeLM contextual shift 0.593937 1.0 8 1.0 223 68 0.9553 0.5752 57.52 0.285 0.7575 PATHWAY: Protein degradation; proteasomal Pup-dependent pathway. {ECO:0000255|HAMAP-Rule:MF_02106}. proteasome ProteomeLM contextual percentile 0.95; strong pocket/AF2Bind evidence; matched: proteasome /main_page_ml/ML1321 2026-05-30T13:09:52Z 79 ML2655 Q05862 fbpC fbpC2 ML2655 Diacylglycerol acyltransferase/mycolyltransferase Ag85C (DGAT) (EC 2.3.1.122) (EC 2.3.1.20) (Acyl-CoA:diacylglycerol acyltransferase) (Antigen 85 complex C) (85C) (Ag85C) (Fibronectin-binding protein C) (Fbps C) 333 77.436 Strong candidate 0.6886 ProteomeLM contextual shift 0.13210411 1.0 58 1.0 679 26 0.9288 0.8735 87.35 0.48 1.0 2.3.1.122; 2.3.1.20 transferase ProteomeLM contextual percentile 0.69; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model; matched: transferase /main_page_ml/ML2655 2026-05-30T13:09:52Z 80 ML1947 Q7AQ14 fum fumC ML1947 Fumarate hydratase class II (Fumarase C) (EC 4.2.1.2) (Aerobic fumarase) (Iron-independent fumarase) 474 77.406 Strong candidate 0.5802 ProteomeLM contextual shift 0.11442815 1.0 224 1.0 1482 0 0.3429 0.9299 92.99 0.64 1.0 4.2.1.2 PATHWAY: Carbohydrate metabolism; tricarboxylic acid cycle; (S)-malate from fumarate: step 1/1. {ECO:0000256|HAMAP-Rule:MF_00743}. ProteomeLM contextual percentile 0.58; strong pocket/AF2Bind evidence; essential-process annotation; high-confidence Boltz2 model /main_page_ml/ML1947 2026-05-30T13:09:52Z 81 ML0127 Q9CD89 ML0127 Rhamnosyl O-methyltransferase (EC 2.1.1.-) 229 77.344 Strong candidate 0.7769 ProteomeLM contextual shift 0.16049628 1.0 40 1.0 722 70 0.9635 0.9451 94.51 0.285 1.0 2.1.1.- cell wall, transferase ProteomeLM contextual percentile 0.78; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: cell wall, transferase /main_page_ml/ML0127 2026-05-30T13:09:52Z 82 ML2083 Q7APZ1 ilvG ML2083 acetolactate synthase (EC 2.2.1.6) 548 77.328 Strong candidate 0.6422 ProteomeLM contextual shift 0.12346427 1.0 52 1.0 1690 92 0.9711 0.945 94.5 0.52 1.0 2.2.1.6 PATHWAY: Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 1/4. {ECO:0000256|ARBA:ARBA00004974}.; PATHWAY: Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 1/4. {ECO:0000256|ARBA:ARBA00005025}. enzyme, synthase, cofactor ProteomeLM contextual percentile 0.64; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model; matched: enzyme, synthase, cofactor /main_page_ml/ML2083 2026-05-30T13:09:52Z 83 ML2622 Q9CCZ9 trmB ML2622 MLCL622.20c tRNA (guanine-N(7)-)-methyltransferase (EC 2.1.1.33) (tRNA (guanine(46)-N(7))-methyltransferase) (tRNA(m7G46)-methyltransferase) 230 77.29 Strong candidate 0.5915 ProteomeLM contextual shift 0.116191305 1.0 36 1.0 747 114 0.9745 0.8788 87.88 0.64 1.0 2.1.1.33 PATHWAY: tRNA modification; N(7)-methylguanine-tRNA biosynthesis. {ECO:0000255|HAMAP-Rule:MF_01057}. transferase ProteomeLM contextual percentile 0.59; strong pocket/AF2Bind evidence; essential-process annotation; high-confidence Boltz2 model; matched: transferase /main_page_ml/ML2622 2026-05-30T13:09:52Z 84 ML1655 Q9CBS7 kasA ML1655 MLCB1243.20c 3-oxoacyl-[acyl-carrier-protein] synthase 1 (EC 2.3.1.293) (Beta-ketoacyl-ACP synthase 1) (KAS 1) 416 77.104 Strong candidate 0.5075 ProteomeLM contextual shift 0.103608 1.0 88 1.0 1309 122 0.9816 0.9741 97.41 0.73 1.0 2.3.1.293 PATHWAY: Lipid metabolism; mycolic acid biosynthesis. {ECO:0000250|UniProtKB:P9WQD9}. mycolic, lipid metabolism, synthase ProteomeLM contextual percentile 0.51; strong pocket/AF2Bind evidence; essential-process annotation; high-confidence Boltz2 model; matched: mycolic, lipid metabolism, synthase /main_page_ml/ML1655 2026-05-30T13:09:52Z 85 ML0987 P35901 recA ML0987 Protein RecA (Recombinase A) [Cleaved into: Mle RecA intein] 711 77.034 Strong candidate 0.9016 ProteomeLM contextual shift 0.31819195 1.0 104 1.0 2157 8 0.7017 0.7852 78.52 0.2 0.8625 ProteomeLM contextual percentile 0.90; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML0987 2026-05-30T13:09:52Z 86 ML0799 Q9CCI0 ML0799 YbaK/aminoacyl-tRNA synthetase-associated domain-containing protein 135 77.027 Strong candidate 0.9486 ProteomeLM contextual shift 0.5586137 1.0 24 1.0 286 32 0.9287 0.6325 63.25 0.125 1.0 aminoacyl-trna, synthetase ProteomeLM contextual percentile 0.95; strong pocket/AF2Bind evidence; matched: aminoacyl-trna, synthetase /main_page_ml/ML0799 2026-05-30T13:09:52Z 87 ML0105 Q9CDA8 embA ML0105 Probable arabinosyltransferase A (EC 2.4.2.-) 1111 76.996 Strong candidate 0.7951 ProteomeLM contextual shift 0.1681556 1.0 331 1.0 3393 0 0.3822 0.9217 92.17 0.285 0.925 2.4.2.- cell wall, transferase ProteomeLM contextual percentile 0.80; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: cell wall, transferase /main_page_ml/ML0105 2026-05-30T13:09:52Z 88 ML1955 Q9X796 truA ML1955 MLCB1222.25c tRNA pseudouridine synthase A (EC 5.4.99.12) (tRNA pseudouridine(38-40) synthase) (tRNA pseudouridylate synthase I) (tRNA-uridine isomerase I) 286 76.845 Strong candidate 0.6591 ProteomeLM contextual shift 0.12696378 1.0 75 1.0 572 148 0.9745 0.9175 91.75 0.48 1.0 5.4.99.12 isomerase, synthase ProteomeLM contextual percentile 0.66; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model; matched: isomerase, synthase /main_page_ml/ML1955 2026-05-30T13:09:52Z 89 ML0300 Q9ZBL5 thiE ML0300 MLCB1450.23c Thiamine-phosphate synthase (TP synthase) (TPS) (EC 2.5.1.3) (Thiamine-phosphate pyrophosphorylase) (TMP pyrophosphorylase) (TMP-PPase) 235 76.803 Strong candidate 0.542 ProteomeLM contextual shift 0.108024076 1.0 52 1.0 773 136 0.9993 0.9133 91.33 0.685 1.0 2.5.1.3 PATHWAY: Cofactor biosynthesis; thiamine diphosphate biosynthesis; thiamine phosphate from 4-amino-2-methyl-5-diphosphomethylpyrimidine and 4-methyl-5-(2-phosphoethyl)-thiazole: step 1/1. {ECO:0000255|HAMAP-Rule:MF_00097}. cofactor biosynthesis, synthase, cofactor ProteomeLM contextual percentile 0.54; strong pocket/AF2Bind evidence; essential-process annotation; high-confidence Boltz2 model; matched: cofactor biosynthesis, synthase, cofactor /main_page_ml/ML0300 2026-05-30T13:09:52Z 90 ML2020 Q9CBG0 ML2020 Putative S-adenosyl-L-methionine-dependent methyltransferase ML2020 (EC 2.1.1.-) 303 76.791 Strong candidate 0.7393 ProteomeLM contextual shift 0.14653908 1.0 38 1.0 979 134 0.991 0.8714 87.14 0.36 1.0 2.1.1.- transferase ProteomeLM contextual percentile 0.74; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model; matched: transferase /main_page_ml/ML2020 2026-05-30T13:09:52Z 91 ML1680 O33128 fbiD ML1680 MLCB637.37c Phosphoenolpyruvate guanylyltransferase (PEP guanylyltransferase) (EC 2.7.7.105) 216 76.779 Strong candidate 0.5351 ProteomeLM contextual shift 0.10734814 1.0 18 1.0 687 78 0.9897 0.935 93.5 0.685 1.0 2.7.7.105 PATHWAY: Cofactor biosynthesis; coenzyme F420 biosynthesis. {ECO:0000255|HAMAP-Rule:MF_02114}. cofactor biosynthesis, enzyme, transferase, cofactor ProteomeLM contextual percentile 0.54; strong pocket/AF2Bind evidence; essential-process annotation; high-confidence Boltz2 model; matched: cofactor biosynthesis, enzyme, transferase, cofactor /main_page_ml/ML1680 2026-05-30T13:09:52Z 92 ML1835 Q7AQ21 ML1835 N-acetyltransferase domain-containing protein 227 76.761 Strong candidate 0.8622 ProteomeLM contextual shift 0.2234512 1.0 46 1.0 703 44 0.9238 0.7586 75.86 0.2 1.0 transferase ProteomeLM contextual percentile 0.86; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: transferase /main_page_ml/ML1835 2026-05-30T13:09:52Z 93 ML2011 Q7AQ05 aao ML2011 D-amino-acid oxidase (EC 1.4.3.3) 320 76.751 Strong candidate 0.6598 ProteomeLM contextual shift 0.12745906 1.0 70 1.0 1098 276 0.9987 0.9059 90.59 0.48 1.0 1.4.3.3 cofactor ProteomeLM contextual percentile 0.66; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model; matched: cofactor /main_page_ml/ML2011 2026-05-30T13:09:52Z 94 ML0570 P46713 gapA gap ML0570 B1496_C3_199 Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) (EC 1.2.1.12) (NAD-dependent glyceraldehyde-3-phosphate dehydrogenase) 339 76.739 Strong candidate 0.5282 ProteomeLM contextual shift 0.106615186 1.0 124 1.0 1044 54 0.8099 0.9553 95.53 0.685 1.0 1.2.1.12 PATHWAY: Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 1/5. {ECO:0000305}. nad, dehydrogenase ProteomeLM contextual percentile 0.53; strong pocket/AF2Bind evidence; essential-process annotation; high-confidence Boltz2 model; matched: nad, dehydrogenase /main_page_ml/ML0570 2026-05-30T13:09:52Z 95 ML1225 Q49622 nadA ML1225 B1170_C2_201 Quinolinate synthase (EC 2.5.1.72) 352 76.736 Strong candidate 0.5169 ProteomeLM contextual shift 0.10448705 1.0 40 1.0 1098 84 0.8969 0.9044 90.44 0.73 1.0 2.5.1.72 PATHWAY: Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from iminoaspartate: step 1/1. {ECO:0000255|HAMAP-Rule:MF_00568}. nad, cofactor biosynthesis, synthetase, synthase, cofactor ProteomeLM contextual percentile 0.52; strong pocket/AF2Bind evidence; essential-process annotation; high-confidence Boltz2 model; matched: nad, cofactor biosynthesis, synthetase, synthase, cofactor /main_page_ml/ML1225 2026-05-30T13:09:52Z 96 ML0492 P46697 ppiB ppi ML0492 B1177_F3_97 MLCB1259.10c Probable peptidyl-prolyl cis-trans isomerase B (PPIase B) (EC 5.2.1.8) (Rotamase B) 295 76.692 Strong candidate 0.7594 ProteomeLM contextual shift 0.15264226 1.0 48 1.0 907 44 0.9659 0.7913 79.13 0.36 1.0 5.2.1.8 isomerase ProteomeLM contextual percentile 0.76; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model; matched: isomerase /main_page_ml/ML0492 2026-05-30T13:09:52Z 97 ML1653 Q7AQ33 fabD ML1653 Malonyl CoA-acyl carrier protein transacylase (EC 2.3.1.39) 304 76.649 Strong candidate 0.5714 ProteomeLM contextual shift 0.11245882 1.0 32 1.0 979 134 0.9931 0.9449 94.49 0.61 1.0 2.3.1.39 PATHWAY: Lipid metabolism; fatty acid biosynthesis. {ECO:0000256|ARBA:ARBA00005194}. lipid metabolism, fatty acid biosynthesis, transferase ProteomeLM contextual percentile 0.57; strong pocket/AF2Bind evidence; essential-process annotation; high-confidence Boltz2 model; matched: lipid metabolism, fatty acid biosynthesis, transferase /main_page_ml/ML1653 2026-05-30T13:09:52Z 98 ML0321 Q9CCW6 ispD ML0321 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase (EC 2.7.7.60) (4-diphosphocytidyl-2C-methyl-D-erythritol synthase) (MEP cytidylyltransferase) (MCT) 241 76.581 Strong candidate 0.609 ProteomeLM contextual shift 0.11842569 1.0 34 1.0 760 74 0.9701 0.8965 89.65 0.565 1.0 2.7.7.60 PATHWAY: Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 2/6. {ECO:0000255|HAMAP-Rule:MF_00108}. isoprenoid, transferase, synthase ProteomeLM contextual percentile 0.61; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model; matched: isoprenoid, transferase, synthase /main_page_ml/ML0321 2026-05-30T13:09:52Z 99 ML0914 O69552 murG ML0914 MLCB268.02c UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase (EC 2.4.1.227) (Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase) 407 76.475 Strong candidate 0.4474 ProteomeLM contextual shift 0.0973899 1.0 58 1.0 1296 150 0.9668 0.8518 85.18 0.865 1.0 2.4.1.227 PATHWAY: Cell wall biogenesis; peptidoglycan biosynthesis. {ECO:0000255|HAMAP-Rule:MF_00033}. cell division, peptidoglycan, cell wall, mur, transferase ProteomeLM contextual percentile 0.45; strong pocket/AF2Bind evidence; essential-process annotation; high-confidence Boltz2 model; matched: cell division, peptidoglycan, cell wall, mur, transferase /main_page_ml/ML0914 2026-05-30T13:09:52Z 100 ML1273 Q9CC53 trpA ML1273 Tryptophan synthase alpha chain (EC 4.2.1.20) 270 76.401 Strong candidate 0.5551 ProteomeLM contextual shift 0.10991638 1.0 32 1.0 904 188 0.9977 0.9171 91.71 0.64 1.0 4.2.1.20 PATHWAY: Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 5/5. {ECO:0000255|HAMAP-Rule:MF_00131}. synthase ProteomeLM contextual percentile 0.56; strong pocket/AF2Bind evidence; essential-process annotation; high-confidence Boltz2 model; matched: synthase /main_page_ml/ML1273 2026-05-30T13:09:52Z 101 ML1503 Q9CBX1 ML1503.1 ML1503A Putative pterin-4-alpha-carbinolamine dehydratase (PHS) (EC 4.2.1.96) (4-alpha-hydroxy-tetrahydropterin dehydratase) (Pterin carbinolamine dehydratase) (PCD) 94 76.391 Strong candidate 0.7381 ProteomeLM contextual shift 0.14617495 1.0 38 1.0 228 0 0.3812 0.9408 94.08 0.36 0.895 4.2.1.96 ProteomeLM contextual percentile 0.74; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model /main_page_ml/ML1503 2026-05-30T13:09:52Z 102 ML1818 Q9CBL1 trxB ML1818 Thioredoxin 130 76.298 Strong candidate 0.9217 ProteomeLM contextual shift 0.4387319 1.0 30 1.0 273 26 0.7707 0.7439 74.39 0.08 1.0 reductase ProteomeLM contextual percentile 0.92; strong pocket/AF2Bind evidence; matched: reductase /main_page_ml/ML1818 2026-05-30T13:09:52Z 103 ML0916 Q9CCE5 ftsQ ML0916 Cell division protein FtsQ 341 76.295 Strong candidate 0.8966 ProteomeLM contextual shift 0.297543 1.0 14 1.0 1046 6 0.6401 0.6989 69.89 0.215 0.8625 cell division, ftsz, fts ProteomeLM contextual percentile 0.90; strong pocket/AF2Bind evidence; matched: cell division, ftsz, fts /main_page_ml/ML0916 2026-05-30T13:09:52Z 104 ML1683 O33125 hupB hlp lbp21 ML1683 MLCB637.34 DNA-binding protein HupB (HupB) (EC 1.16.3.1) (21 kDa laminin-2-binding protein) (ML-LBP21) (DNA-binding protein HU homolog) (Histone-like protein) (Hlp) 200 76.235 Strong candidate 0.7826 ProteomeLM contextual shift 0.1626952 1.0 56 1.0 669 138 0.9589 0.5744 57.44 0.405 1.0 1.16.3.1 cell wall ProteomeLM contextual percentile 0.78; strong pocket/AF2Bind evidence; functional annotation support; matched: cell wall /main_page_ml/ML1683 2026-05-30T13:09:52Z 105 ML0984 Q9CCC2 ML0984 Limonene-1,2-epoxide hydrolase domain-containing protein 164 76.189 Strong candidate 0.9298 ProteomeLM contextual shift 0.48604572 1.0 60 1.0 497 100 0.94 0.8645 86.45 0.0 1.0 hydrolase ProteomeLM contextual percentile 0.93; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: hydrolase /main_page_ml/ML0984 2026-05-30T13:09:52Z 106 ML1133 P45834 rpmE ML1133 Large ribosomal subunit protein bL31 (50S ribosomal protein L31) 84 76.006 Strong candidate 0.8603 ProteomeLM contextual shift 0.21875052 1.0 10 1.0 289 74 0.8826 0.5246 52.46 0.335 0.895 translation, ribosome, ribosomal, cofactor ProteomeLM contextual percentile 0.86; strong pocket/AF2Bind evidence; matched: translation, ribosome, ribosomal, cofactor /main_page_ml/ML1133 2026-05-30T13:09:52Z 107 ML0132 Q9CD84 fadD29 ML0132 Acyl-CoA synthetase 680 75.993 Strong candidate 0.8722 ProteomeLM contextual shift 0.24340127 1.0 90 1.0 2062 4 0.5652 0.7967 79.67 0.125 1.0 cell wall, enzyme, ligase, transferase ProteomeLM contextual percentile 0.87; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: cell wall, enzyme, ligase, transferase /main_page_ml/ML0132 2026-05-30T13:09:52Z 108 ML0092 Q9CDB8 glf ML0092 UDP-galactopyranose mutase (EC 5.4.99.9) (UDP-GALP mutase) (Uridine 5-diphosphate galactopyranose mutase) 413 75.981 Strong candidate 0.5877 ProteomeLM contextual shift 0.11567568 1.0 162 1.0 1291 104 0.9409 0.9111 91.11 0.565 1.0 5.4.99.9 PATHWAY: Cell wall biogenesis; cell wall polysaccharide biosynthesis. {ECO:0000256|ARBA:ARBA00004776}. cell wall, cofactor ProteomeLM contextual percentile 0.59; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model; matched: cell wall, cofactor /main_page_ml/ML0092 2026-05-30T13:09:52Z 109 ML2487 Q9CB28 pyrE ML2487 Orotate phosphoribosyltransferase (OPRT) (OPRTase) (EC 2.4.2.10) 179 75.893 Strong candidate 0.5395 ProteomeLM contextual shift 0.107646964 1.0 38 1.0 584 94 0.9422 0.9212 92.12 0.64 1.0 2.4.2.10 PATHWAY: Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 1/2. {ECO:0000255|HAMAP-Rule:MF_01208}. transferase, cofactor ProteomeLM contextual percentile 0.54; strong pocket/AF2Bind evidence; essential-process annotation; high-confidence Boltz2 model; matched: transferase, cofactor /main_page_ml/ML2487 2026-05-30T13:09:52Z 110 ML1297 Q9CC42 uppP bacA upk ML1297 B2126_C2_190/B2126_C3_227 Undecaprenyl-diphosphatase (EC 3.6.1.27) (Bacitracin resistance protein) (Undecaprenyl pyrophosphate phosphatase) 282 75.881 Strong candidate 0.6585 ProteomeLM contextual shift 0.12693807 1.0 70 1.0 947 202 0.967 0.8832 88.32 0.45 1.0 3.6.1.27 peptidoglycan, cell wall ProteomeLM contextual percentile 0.66; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model; matched: peptidoglycan, cell wall /main_page_ml/ML1297 2026-05-30T13:09:52Z 111 ML0759 Q9CCK1 fbiA ML0759 Phosphoenolpyruvate transferase (EC 2.7.8.28) (EPPG:FO PEP transferase) 333 75.88 Strong candidate 0.5388 ProteomeLM contextual shift 0.107580386 1.0 94 1.0 1184 94 0.9513 0.832 83.2 0.685 1.0 2.7.8.28 PATHWAY: Cofactor biosynthesis; coenzyme F420 biosynthesis. {ECO:0000255|HAMAP-Rule:MF_01257}. cofactor biosynthesis, enzyme, transferase, cofactor ProteomeLM contextual percentile 0.54; strong pocket/AF2Bind evidence; essential-process annotation; high-confidence Boltz2 model; matched: cofactor biosynthesis, enzyme, transferase, cofactor /main_page_ml/ML0759 2026-05-30T13:09:52Z 112 ML1583 Q9CBU3 dxr ML1583 1-deoxy-D-xylulose 5-phosphate reductoisomerase (DXP reductoisomerase) (EC 1.1.1.267) (1-deoxyxylulose-5-phosphate reductoisomerase) (2-C-methyl-D-erythritol 4-phosphate synthase) 406 75.859 Strong candidate 0.4937 ProteomeLM contextual shift 0.10228119 1.0 104 1.0 849 74 0.9329 0.8978 89.78 0.73 1.0 1.1.1.267 PATHWAY: Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 1/6. {ECO:0000255|HAMAP-Rule:MF_00183}. nad, isoprenoid, isomerase, synthase, cofactor ProteomeLM contextual percentile 0.49; strong pocket/AF2Bind evidence; essential-process annotation; high-confidence Boltz2 model; matched: nad, isoprenoid, isomerase, synthase, cofactor /main_page_ml/ML1583 2026-05-30T13:09:52Z 113 ML0715 Q9CCL5 lpqC ML0715 Secreted hydrolase 304 75.786 Strong candidate 0.8571 ProteomeLM contextual shift 0.21608903 1.0 38 1.0 637 58 0.9708 0.9186 91.86 0.08 1.0 hydrolase ProteomeLM contextual percentile 0.86; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: hydrolase /main_page_ml/ML0715 2026-05-30T13:09:52Z 114 ML0072 P13367 sodA ML0072 Superoxide dismutase [Mn] (EC 1.15.1.1) 207 75.774 Strong candidate 0.6172 ProteomeLM contextual shift 0.11936052 1.0 94 1.0 655 68 0.9328 0.9573 95.73 0.48 1.0 1.15.1.1 cofactor ProteomeLM contextual percentile 0.62; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model; matched: cofactor /main_page_ml/ML0072 2026-05-30T13:09:52Z 115 ML0517 Q9CCS5 aroK ML0517 Shikimate kinase (SK) (EC 2.7.1.71) 199 75.715 Strong candidate 0.567 ProteomeLM contextual shift 0.11173834 1.0 20 1.0 651 108 0.986 0.8068 80.68 0.64 1.0 2.7.1.71 PATHWAY: Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 5/7. {ECO:0000255|HAMAP-Rule:MF_00109}. kinase, cofactor ProteomeLM contextual percentile 0.57; strong pocket/AF2Bind evidence; essential-process annotation; high-confidence Boltz2 model; matched: kinase, cofactor /main_page_ml/ML0517 2026-05-30T13:09:52Z 116 ML2677 Q7APS2 ML2677 TetR-family transcriptional regulator 236 75.711 Strong candidate 0.9524 ProteomeLM contextual shift 0.57862186 1.0 117 1.0 756 96 0.9527 0.6252 62.52 0.125 0.8625 transcription ProteomeLM contextual percentile 0.95; strong pocket/AF2Bind evidence; matched: transcription /main_page_ml/ML2677 2026-05-30T13:09:52Z 117 ML1854 O32990 rpsQ ML1854 MLCB2492.11 Small ribosomal subunit protein uS17 (30S ribosomal protein S17) 126 75.711 Strong candidate 0.8916 ProteomeLM contextual shift 0.29071993 1.0 12 1.0 413 64 0.9267 0.658 65.8 0.215 0.8625 translation, ribosome, ribosomal ProteomeLM contextual percentile 0.89; strong pocket/AF2Bind evidence; matched: translation, ribosome, ribosomal /main_page_ml/ML1854 2026-05-30T13:09:52Z 118 ML2685 P46389 rpsF ML2685 MLCB1913.21c Small ribosomal subunit protein bS6 (30S ribosomal protein S6) 96 75.663 Strong candidate 0.8427 ProteomeLM contextual shift 0.1985188 1.0 16 1.0 307 38 0.9413 0.9292 92.92 0.215 0.7575 translation, ribosome, ribosomal ProteomeLM contextual percentile 0.84; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: translation, ribosome, ribosomal /main_page_ml/ML2685 2026-05-30T13:09:52Z 119 ML2430 P46725 proC ML2430 B2168_C2_211 Pyrroline-5-carboxylate reductase (P5C reductase) (P5CR) (EC 1.5.1.2) (PCA reductase) 294 75.661 Strong candidate 0.5821 ProteomeLM contextual shift 0.11464247 1.0 31 1.0 990 216 0.9631 0.8989 89.89 0.565 1.0 1.5.1.2 PATHWAY: Amino-acid biosynthesis; L-proline biosynthesis; L-proline from L-glutamate 5-semialdehyde: step 1/1. {ECO:0000255|HAMAP-Rule:MF_01925}. nad, reductase ProteomeLM contextual percentile 0.58; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model; matched: nad, reductase /main_page_ml/ML2430 2026-05-30T13:09:52Z 120 ML0881 O69583 qcrC ML0881 MLCB268.36 Cytochrome bc1 complex cytochrome c subunit (EC 7.1.1.8) (Cytochrome bc1 reductase complex subunit QcrC) (Ubiquinol--cytochrome c reductase cytochrome c subunit) 289 75.63 Strong candidate 0.6773 ProteomeLM contextual shift 0.1304481 1.0 36 1.0 922 110 0.966 0.7324 73.24 0.48 1.0 7.1.1.8 reductase ProteomeLM contextual percentile 0.68; strong pocket/AF2Bind evidence; functional annotation support; matched: reductase /main_page_ml/ML0881 2026-05-30T13:09:52Z 121 ML1189 Q7AQ87 ML1189 Uncharacterized protein 127 75.61 Strong candidate 0.9781 ProteomeLM contextual shift 0.7453265 1.0 26 1.0 304 100 0.9901 0.4777 47.77 0.08 1.0 oxidoreductase, reductase ProteomeLM contextual percentile 0.98; strong pocket/AF2Bind evidence; matched: oxidoreductase, reductase /main_page_ml/ML1189 2026-05-30T13:09:52Z 122 ML1106 Q9CC90 ML1106 Uncharacterized protein 113 75.61 Strong candidate 0.9706 ProteomeLM contextual shift 0.66972005 1.0 12 1.0 357 36 0.897 0.6091 60.91 0.08 0.895 oxidoreductase, reductase ProteomeLM contextual percentile 0.97; strong pocket/AF2Bind evidence; matched: oxidoreductase, reductase /main_page_ml/ML1106 2026-05-30T13:09:52Z 123 ML0210 O69540 ppa ML0210 MLCB2548.21 Inorganic pyrophosphatase (EC 3.6.1.1) (Pyrophosphate phospho-hydrolase) (PPase) 162 75.595 Strong candidate 0.6178 ProteomeLM contextual shift 0.119446486 1.0 82 1.0 332 16 0.7251 0.9373 93.73 0.48 1.0 3.6.1.1 hydrolase, cofactor ProteomeLM contextual percentile 0.62; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model; matched: hydrolase, cofactor /main_page_ml/ML0210 2026-05-30T13:09:52Z 124 ML1841 O33001 rpmD ML1841 MLCB2492.22 Large ribosomal subunit protein uL30 (50S ribosomal protein L30) 71 75.565 Strong candidate 0.8665 ProteomeLM contextual shift 0.23384897 1.0 8 1.0 243 20 0.8285 0.8361 83.61 0.215 0.7575 translation, ribosome, ribosomal ProteomeLM contextual percentile 0.87; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: translation, ribosome, ribosomal /main_page_ml/ML1841 2026-05-30T13:09:52Z 125 ML2013 Q7AQ03 ML2013 Amidohydrolase-related domain-containing protein 126 75.563 Strong candidate 0.9185 ProteomeLM contextual shift 0.42062363 1.0 14 1.0 410 64 0.8532 0.8414 84.14 0.0 1.0 hydrolase ProteomeLM contextual percentile 0.92; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: hydrolase /main_page_ml/ML2013 2026-05-30T13:09:52Z 126 ML0711 Q9CCL6 ML0711 Gamma-glutamylcyclotransferase 159 75.446 Strong candidate 0.7932 ProteomeLM contextual shift 0.1670025 1.0 26 1.0 506 58 0.899 0.8683 86.83 0.2 1.0 transferase ProteomeLM contextual percentile 0.79; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: transferase /main_page_ml/ML0711 2026-05-30T13:09:52Z 127 ML2640 Q9CCZ4 ML2640 Putative S-adenosyl-L-methionine-dependent methyltransferase ML2640 (EC 2.1.1.-) 310 75.304 Strong candidate 0.6848 ProteomeLM contextual shift 0.13108495 1.0 43 1.0 1317 226 0.9953 0.9134 91.34 0.36 1.0 2.1.1.- transferase ProteomeLM contextual percentile 0.68; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model; matched: transferase /main_page_ml/ML2640 2026-05-30T13:09:52Z 128 ML2131 O33065 pdxH ML2131 MLCB57.46 Pyridoxine/pyridoxamine 5'-phosphate oxidase (EC 1.4.3.5) (PNP/PMP oxidase) (PNPOx) (Pyridoxal 5'-phosphate synthase) 219 75.231 Strong candidate 0.5238 ProteomeLM contextual shift 0.105756864 1.0 52 1.0 641 46 0.8562 0.9098 90.98 0.64 1.0 1.4.3.5 PATHWAY: Cofactor metabolism; pyridoxal 5'-phosphate salvage; pyridoxal 5'-phosphate from pyridoxamine 5'-phosphate: step 1/1. {ECO:0000255|HAMAP-Rule:MF_01629}.; PATHWAY: Cofactor metabolism; pyridoxal 5'-phosphate salvage; pyridoxal 5'-phosphate from pyridoxine 5'-phosphate: step 1/1. {ECO:0000255|HAMAP-Rule:MF_01629}. synthase, cofactor ProteomeLM contextual percentile 0.52; strong pocket/AF2Bind evidence; essential-process annotation; high-confidence Boltz2 model; matched: synthase, cofactor /main_page_ml/ML2131 2026-05-30T13:09:52Z 129 ML1703 O33104 gatC ML1703 MLCB637.12 Glutamyl-tRNA(Gln) amidotransferase subunit C (Glu-ADT subunit C) (EC 6.3.5.-) 99 75.195 Strong candidate 0.7281 ProteomeLM contextual shift 0.14420193 1.0 14 1.0 321 48 0.8322 0.7663 76.63 0.405 0.895 6.3.5.- translation, transferase, synthase ProteomeLM contextual percentile 0.73; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model; matched: translation, transferase, synthase /main_page_ml/ML1703 2026-05-30T13:09:52Z 130 ML0729 Q49670 ML0729 B1308_C2_167 u1308r Nucleoside triphosphate pyrophosphatase (EC 3.6.1.9) (Nucleotide pyrophosphatase) (Nucleotide PPase) 213 75.181 Strong candidate 0.6028 ProteomeLM contextual shift 0.11756752 1.0 48 1.0 667 56 0.9319 0.9484 94.84 0.48 1.0 3.6.1.9 cofactor ProteomeLM contextual percentile 0.60; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model; matched: cofactor /main_page_ml/ML0729 2026-05-30T13:09:52Z 131 ML0522 Q9CCS0 efp ML0522 Elongation factor P (EF-P) 187 75.143 Strong candidate 0.7719 ProteomeLM contextual shift 0.15857008 1.0 14 1.0 569 16 0.7497 0.88 88.0 0.285 0.8625 PATHWAY: Protein biosynthesis; polypeptide chain elongation. {ECO:0000255|HAMAP-Rule:MF_00141}. translation ProteomeLM contextual percentile 0.77; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: translation /main_page_ml/ML0522 2026-05-30T13:09:52Z 132 ML2192 Q50043 phoS3 ML2192 Phosphate-binding protein 429 75.139 Strong candidate 0.8477 ProteomeLM contextual shift 0.20418563 1.0 61 1.0 887 18 0.8219 0.7843 78.43 0.2 0.8625 ProteomeLM contextual percentile 0.85; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML2192 2026-05-30T13:09:52Z 133 ML0239 Q9CD54 ML0239 Uncharacterized protein 262 75.133 Strong candidate 0.7588 ProteomeLM contextual shift 0.1525182 1.0 26 1.0 834 96 0.9841 0.9576 95.76 0.2 1.0 hydrolase ProteomeLM contextual percentile 0.76; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: hydrolase /main_page_ml/ML0239 2026-05-30T13:09:52Z 134 ML1688 O33120 gltX gltS ML1688 MLCB637.29 Glutamate--tRNA ligase (EC 6.1.1.17) (Glutamyl-tRNA synthetase) (GluRS) 502 75.132 Strong candidate 0.557 ProteomeLM contextual shift 0.11001638 1.0 84 1.0 1516 20 0.6949 0.9236 92.36 0.57 1.0 6.1.1.17 aminoacyl-trna, trna ligase, ligase, synthetase ProteomeLM contextual percentile 0.56; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model; matched: aminoacyl-trna, trna ligase, ligase, synthetase /main_page_ml/ML1688 2026-05-30T13:09:52Z 135 ML2314 Q9CB81 glpK ML2314 Glycerol kinase (EC 2.7.1.30) (ATP:glycerol 3-phosphotransferase) (Glycerokinase) (GK) 508 75.126 Strong candidate 0.5113 ProteomeLM contextual shift 0.10406657 1.0 100 1.0 1556 64 0.8884 0.9431 94.31 0.64 1.0 2.7.1.30 PATHWAY: Polyol metabolism; glycerol degradation via glycerol kinase pathway; sn-glycerol 3-phosphate from glycerol: step 1/1. {ECO:0000255|HAMAP-Rule:MF_00186}. kinase, transferase ProteomeLM contextual percentile 0.51; strong pocket/AF2Bind evidence; essential-process annotation; high-confidence Boltz2 model; matched: kinase, transferase /main_page_ml/ML2314 2026-05-30T13:09:52Z 136 ML1263 Q9X7C2 hisF ML1263 MLCB1610.26 Imidazole glycerol phosphate synthase subunit HisF (EC 4.3.2.10) (IGP synthase cyclase subunit) (IGP synthase subunit HisF) (ImGP synthase subunit HisF) (IGPS subunit HisF) 261 75.113 Strong candidate 0.5307 ProteomeLM contextual shift 0.10670311 1.0 16 1.0 588 132 0.9891 0.8739 87.39 0.64 1.0 4.3.2.10 PATHWAY: Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 5/9. lyase, synthase ProteomeLM contextual percentile 0.53; strong pocket/AF2Bind evidence; essential-process annotation; high-confidence Boltz2 model; matched: lyase, synthase /main_page_ml/ML1263 2026-05-30T13:09:52Z 137 ML0136 Q9CD80 lppX ML0136 Putative phthiocerol dimycocerosate transporter LppX (Lipoprotein LppX) 233 75.11 Strong candidate 0.9023 ProteomeLM contextual shift 0.33150908 1.0 24 1.0 739 80 0.9773 0.7406 74.06 0.125 0.8625 cell wall ProteomeLM contextual percentile 0.90; strong pocket/AF2Bind evidence; matched: cell wall /main_page_ml/ML0136 2026-05-30T13:09:52Z 138 ML0394 Q9CCV0 ML0394 Methyltransferase domain-containing protein 170 75.107 Strong candidate 0.9599 ProteomeLM contextual shift 0.61550057 1.0 34 1.0 592 164 0.996 0.6511 65.11 0.0 1.0 transferase ProteomeLM contextual percentile 0.96; strong pocket/AF2Bind evidence; matched: transferase /main_page_ml/ML0394 2026-05-30T13:09:52Z 139 ML0513 Q9CCS9 ML0513 Putative pre-16S rRNA nuclease (EC 3.1.-.-) 184 75.088 Strong candidate 0.8045 ProteomeLM contextual shift 0.17082581 1.0 36 1.0 372 8 0.8025 0.713 71.3 0.24 1.0 3.1.-.- hydrolase ProteomeLM contextual percentile 0.80; strong pocket/AF2Bind evidence; matched: hydrolase /main_page_ml/ML0513 2026-05-30T13:09:52Z 140 ML2712 P46610 rnpA ML2712 Ribonuclease P protein component (RNase P protein) (RNaseP protein) (EC 3.1.26.5) (Protein C5) 120 75.065 Strong candidate 0.6823 ProteomeLM contextual shift 0.1308325 1.0 14 1.0 386 52 0.8466 0.8983 89.83 0.36 1.0 3.1.26.5 ProteomeLM contextual percentile 0.68; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model /main_page_ml/ML2712 2026-05-30T13:09:52Z 141 ML1395 Q9CC21 rpmI ML1395 Large ribosomal subunit protein bL35 (50S ribosomal protein L35) 64 75.041 Strong candidate 0.8904 ProteomeLM contextual shift 0.28771317 1.0 10 1.0 216 48 0.9458 0.7004 70.04 0.215 0.7575 translation, ribosome, ribosomal ProteomeLM contextual percentile 0.89; strong pocket/AF2Bind evidence; matched: translation, ribosome, ribosomal /main_page_ml/ML1395 2026-05-30T13:09:52Z 142 ML2348 Q49929 ML2348 L518_C2_147 MLCB2407.02c Uncharacterized glycosyltransferase ML2348 (EC 2.4.-.-) 421 75.029 Strong candidate 0.7544 ProteomeLM contextual shift 0.15104508 1.0 56 1.0 1365 204 0.998 0.8826 88.26 0.24 1.0 2.4.-.- transferase ProteomeLM contextual percentile 0.75; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: transferase /main_page_ml/ML2348 2026-05-30T13:09:52Z 143 ML0082 Q9CDC1 serS ML0082 Serine--tRNA ligase (EC 6.1.1.11) (Seryl-tRNA synthetase) (SerRS) (Seryl-tRNA(Ser/Sec) synthetase) 417 75.007 Strong candidate 0.4574 ProteomeLM contextual shift 0.09840369 1.0 78 1.0 859 50 0.8837 0.9398 93.98 0.73 1.0 6.1.1.11 PATHWAY: Aminoacyl-tRNA biosynthesis; selenocysteinyl-tRNA(Sec) biosynthesis; L-seryl-tRNA(Sec) from L-serine and tRNA(Sec): step 1/1. {ECO:0000255|HAMAP-Rule:MF_00176}. aminoacyl-trna, trna ligase, ligase, synthetase ProteomeLM contextual percentile 0.46; strong pocket/AF2Bind evidence; essential-process annotation; high-confidence Boltz2 model; matched: aminoacyl-trna, trna ligase, ligase, synthetase /main_page_ml/ML0082 2026-05-30T13:09:52Z 144 ML0295 Q9ZBL1 thiD ML0295 MLCB1450.27c Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase (EC 2.7.1.49) (EC 2.7.4.7) (Hydroxymethylpyrimidine kinase) (HMP kinase) (Hydroxymethylpyrimidine phosphate kinase) (HMP-P kinase) (HMP-phosphate kinase) (HMPP kinase) 279 74.928 Strong candidate 0.485 ProteomeLM contextual shift 0.10143127 1.0 42 1.0 926 178 0.993 0.9255 92.55 0.685 1.0 2.7.1.49; 2.7.4.7 PATHWAY: Cofactor biosynthesis; thiamine diphosphate biosynthesis; 4-amino-2-methyl-5-diphosphomethylpyrimidine from 5-amino-1-(5-phospho-D-ribosyl)imidazole: step 2/3.; PATHWAY: Cofactor biosynthesis; thiamine diphosphate biosynthesis; 4-amino-2-methyl-5-diphosphomethylpyrimidine from 5-amino-1-(5-phospho-D-ribosyl)imidazole: step 3/3. cofactor biosynthesis, kinase, cofactor ProteomeLM contextual percentile 0.48; strong pocket/AF2Bind evidence; essential-process annotation; high-confidence Boltz2 model; matched: cofactor biosynthesis, kinase, cofactor /main_page_ml/ML0295 2026-05-30T13:09:52Z 145 ML1589 Q9CBU1 cdsA ML1589 Phosphatidate cytidylyltransferase (EC 2.7.7.41) (CDP-diacylglycerol synthase) (CDP-DAG synthase) (CDP-DG synthase) (CDS) (CDP-diglyceride pyrophosphorylase) (CDP-diglyceride synthase) (CTP:phosphatidate cytidylyltransferase) 312 74.889 Strong candidate 0.5909 ProteomeLM contextual shift 0.11618451 1.0 90 1.0 971 70 0.9893 0.7909 79.09 0.565 1.0 2.7.7.41 PATHWAY: Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 3/3. {ECO:0000250|UniProtKB:P0ABG1}. lipid metabolism, transferase, synthase ProteomeLM contextual percentile 0.59; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model; matched: lipid metabolism, transferase, synthase /main_page_ml/ML1589 2026-05-30T13:09:52Z 146 ML0551 Q9CCQ1 ML0551 Methyltransferase 274 74.875 Strong candidate 0.8308 ProteomeLM contextual shift 0.18828598 1.0 36 1.0 608 120 0.9965 0.9196 91.96 0.08 1.0 transferase ProteomeLM contextual percentile 0.83; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: transferase /main_page_ml/ML0551 2026-05-30T13:09:52Z 147 ML1783 Q9CBN3 ML1783 Transcriptional regulator 322 74.852 Strong candidate 0.9198 ProteomeLM contextual shift 0.42140922 1.0 78 1.0 1096 260 0.9984 0.8134 81.34 0.045 0.8625 transcription ProteomeLM contextual percentile 0.92; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: transcription /main_page_ml/ML1783 2026-05-30T13:09:52Z 148 ML1479 Q9CBY4 clpP2 ML1479 ATP-dependent Clp protease proteolytic subunit 2 (EC 3.4.21.92) (Endopeptidase Clp 2) 214 74.806 Strong candidate 0.6134 ProteomeLM contextual shift 0.11886719 1.0 70 1.0 673 62 0.8505 0.8737 87.37 0.48 1.0 3.4.21.92 protease ProteomeLM contextual percentile 0.61; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model; matched: protease /main_page_ml/ML1479 2026-05-30T13:09:52Z 149 ML1928 Q9CBI3 ML1928 Uncharacterized protein 45 74.8 Strong candidate 0.9893 ProteomeLM contextual shift 0.91211885 1.0 8 1.0 145 20 0.8287 0.7598 75.98 0.0 0.7575 ProteomeLM contextual percentile 0.99; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML1928 2026-05-30T13:09:52Z 150 ML0017 P54743 pknA ML0017 Serine/threonine-protein kinase PknA (EC 2.7.11.1) 437 74.784 Strong candidate 0.6748 ProteomeLM contextual shift 0.12990439 1.0 91 1.0 1370 118 0.9583 0.6565 65.65 0.48 1.0 2.7.11.1 kinase ProteomeLM contextual percentile 0.67; strong pocket/AF2Bind evidence; functional annotation support; matched: kinase /main_page_ml/ML0017 2026-05-30T13:09:52Z 151 ML0895 Q7AQD5 ML0895 3'-5' exoribonuclease (EC 3.1.13.-) 171 74.771 Strong candidate 0.683 ProteomeLM contextual shift 0.13087282 1.0 58 1.0 538 50 0.9757 0.8667 86.67 0.36 1.0 3.1.13.- cofactor ProteomeLM contextual percentile 0.68; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model; matched: cofactor /main_page_ml/ML0895 2026-05-30T13:09:52Z 152 ML1440 Q7AQ50 ML1440 Bifunctional apolipoprotein N-acyltransferase/polyprenol monophosphomannose synthase (EC 2.3.1.269) (EC 2.4.1.83) 277 74.712 Strong candidate 0.604 ProteomeLM contextual shift 0.11764612 1.0 36 1.0 892 122 0.9769 0.8172 81.72 0.52 1.0 2.3.1.269; 2.4.1.83 PATHWAY: Protein modification; lipoprotein biosynthesis (N-acyl transfer). {ECO:0000256|ARBA:ARBA00060519}. transferase, hydrolase, synthase ProteomeLM contextual percentile 0.60; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model; matched: transferase, hydrolase, synthase /main_page_ml/ML1440 2026-05-30T13:09:52Z 153 ML2452 Q9CB44 ML2452 Uncharacterized protein ML2452 123 74.659 Strong candidate 0.9637 ProteomeLM contextual shift 0.6436167 1.0 30 1.0 404 70 0.944 0.7305 73.05 0.0 0.8625 ProteomeLM contextual percentile 0.96; strong pocket/AF2Bind evidence /main_page_ml/ML2452 2026-05-30T13:09:52Z 154 ML2077 O32920 gcvH ML2077 MLCB1788.37c Glycine cleavage system H protein 132 74.603 Strong candidate 0.8145 ProteomeLM contextual shift 0.17597574 1.0 25 1.0 269 10 0.895 0.9494 94.94 0.08 1.0 cofactor ProteomeLM contextual percentile 0.81; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: cofactor /main_page_ml/ML2077 2026-05-30T13:09:52Z 155 ML0626 Q9CCN1 ML0626 Ribosomal RNA small subunit methyltransferase E (EC 2.1.1.193) 257 74.589 Strong candidate 0.6372 ProteomeLM contextual shift 0.12236116 1.0 50 1.0 831 0 0.4063 0.9186 91.86 0.405 1.0 2.1.1.193 ribosomal, transferase ProteomeLM contextual percentile 0.64; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model; matched: ribosomal, transferase /main_page_ml/ML0626 2026-05-30T13:09:52Z 156 ML0678 Q7AQG2 ML0678 Transposase IS116/IS110/IS902 C-terminal domain-containing protein 175 74.552 Strong candidate 0.9643 ProteomeLM contextual shift 0.6452775 1.0 22 1.0 362 24 0.9007 0.5577 55.77 0.08 0.8625 ProteomeLM contextual percentile 0.96; strong pocket/AF2Bind evidence /main_page_ml/ML0678 2026-05-30T13:09:52Z 157 ML1532 Q9CBV6 ald ML1532 Alanine dehydrogenase (EC 1.4.1.1) 371 74.539 Strong candidate 0.4662 ProteomeLM contextual shift 0.099573515 1.0 174 1.0 1132 38 0.9303 0.9523 95.23 0.685 1.0 1.4.1.1 PATHWAY: Amino-acid degradation; L-alanine degradation via dehydrogenase pathway; NH(3) and pyruvate from L-alanine: step 1/1. {ECO:0000256|ARBA:ARBA00005206, ECO:0000256|PIRNR:PIRNR000183}. nad, dehydrogenase ProteomeLM contextual percentile 0.47; strong pocket/AF2Bind evidence; essential-process annotation; high-confidence Boltz2 model; matched: nad, dehydrogenase /main_page_ml/ML1532 2026-05-30T13:09:52Z 158 ML2264 Q9CBB4 ML2264 Uncharacterized protein 203 74.517 Strong candidate 0.9987 ProteomeLM contextual shift 1.152492 1.0 54 1.0 648 78 0.9684 0.5936 59.36 0.0 0.8625 ProteomeLM contextual percentile 1.00; strong pocket/AF2Bind evidence /main_page_ml/ML2264 2026-05-30T13:09:52Z 159 ML0225 O69529 folB ML0225 MLCB2548.06c Dihydroneopterin aldolase (DHNA) (EC 4.1.2.25) (7,8-dihydroneopterin 2'-epimerase) (7,8-dihydroneopterin aldolase) (7,8-dihydroneopterin epimerase) (EC 5.1.99.8) (7,8-dihydroneopterin hydroxylase) (EC 1.13.11.81) (Dihydroneopterin epimerase) (Dihydroneopterin hydroxylase) 132 74.501 Strong candidate 0.4655 ProteomeLM contextual shift 0.09956656 1.0 76 1.0 420 48 0.9437 0.8607 86.07 0.73 1.0 1.13.11.81; 4.1.2.25; 5.1.99.8 PATHWAY: Cofactor biosynthesis; tetrahydrofolate biosynthesis; 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 7,8-dihydroneopterin triphosphate: step 3/4. folate, cofactor biosynthesis, oxidoreductase, isomerase, reductase ProteomeLM contextual percentile 0.47; strong pocket/AF2Bind evidence; essential-process annotation; high-confidence Boltz2 model; matched: folate, cofactor biosynthesis, oxidoreductase, isomerase, reductase /main_page_ml/ML0225 2026-05-30T13:09:52Z 160 ML2635 Q9CCZ7 pntAB ML2635 proton-translocating NAD(P)(+) transhydrogenase (EC 7.1.1.1) 112 74.448 Strong candidate 0.745 ProteomeLM contextual shift 0.14824308 1.0 42 1.0 363 54 0.8853 0.6324 63.24 0.405 0.895 7.1.1.1 nad ProteomeLM contextual percentile 0.74; strong pocket/AF2Bind evidence; functional annotation support; matched: nad /main_page_ml/ML2635 2026-05-30T13:09:52Z 161 ML1044 Q50008 cgoX hemY ML1044 Coproporphyrinogen III oxidase (EC 1.3.3.15) 451 74.443 Strong candidate 0.4906 ProteomeLM contextual shift 0.10186832 1.0 44 1.0 1467 228 0.9955 0.9472 94.72 0.64 1.0 1.3.3.15 PATHWAY: Porphyrin-containing compound metabolism; protoheme biosynthesis. {ECO:0000250|UniProtKB:P32397}. cofactor ProteomeLM contextual percentile 0.49; strong pocket/AF2Bind evidence; essential-process annotation; high-confidence Boltz2 model; matched: cofactor /main_page_ml/ML1044 2026-05-30T13:09:52Z 162 ML1664 Q9CBS5 ML1664 Methyltransferase 157 74.423 Strong candidate 0.8083 ProteomeLM contextual shift 0.17175739 1.0 20 1.0 324 20 0.9141 0.9533 95.33 0.08 1.0 transferase ProteomeLM contextual percentile 0.81; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: transferase /main_page_ml/ML1664 2026-05-30T13:09:52Z 163 ML1173 P50474 ML1173 B1549_C2_211 Uncharacterized protein ML1173 284 74.399 Strong candidate 0.8434 ProteomeLM contextual shift 0.1998213 1.0 46 1.0 791 22 0.6661 0.9657 96.57 0.08 0.8625 ProteomeLM contextual percentile 0.84; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML1173 2026-05-30T13:09:52Z 164 ML1128 Q50140 lysA ML1128 Diaminopimelate decarboxylase (DAP decarboxylase) (DAPDC) (EC 4.1.1.20) 472 74.382 Strong candidate 0.5013 ProteomeLM contextual shift 0.103120975 1.0 134 1.0 1480 128 0.9847 0.9038 90.38 0.64 1.0 4.1.1.20 PATHWAY: Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; L-lysine from DL-2,6-diaminopimelate: step 1/1. {ECO:0000255|HAMAP-Rule:MF_02120}. cofactor ProteomeLM contextual percentile 0.50; strong pocket/AF2Bind evidence; essential-process annotation; high-confidence Boltz2 model; matched: cofactor /main_page_ml/ML1128 2026-05-30T13:09:52Z 165 ML2609 Q7APT4 ML2609 CopY family transcriptional regulator 135 74.373 Strong candidate 0.8985 ProteomeLM contextual shift 0.30151716 1.0 50 1.0 455 100 0.9477 0.68 68.0 0.125 0.8625 transcription ProteomeLM contextual percentile 0.90; strong pocket/AF2Bind evidence; matched: transcription /main_page_ml/ML2609 2026-05-30T13:09:52Z 166 ML0104 Q9CDA9 embB ML0104 Probable arabinosyltransferase B (EC 2.4.2.-) 1083 74.367 Strong candidate 0.7187 ProteomeLM contextual shift 0.14157946 1.0 193 1.0 3309 0 0.4862 0.9263 92.63 0.285 0.925 2.4.2.- cell wall, transferase ProteomeLM contextual percentile 0.72; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: cell wall, transferase /main_page_ml/ML0104 2026-05-30T13:09:52Z 167 ML2048 Q7AQ01 ML2048 Uncharacterized protein 85 74.343 Strong candidate 0.9442 ProteomeLM contextual shift 0.5429587 1.0 14 1.0 291 72 0.9558 0.5745 57.45 0.08 0.895 oxidoreductase, reductase ProteomeLM contextual percentile 0.94; strong pocket/AF2Bind evidence; matched: oxidoreductase, reductase /main_page_ml/ML2048 2026-05-30T13:09:52Z 168 ML1685 O33123 leuC ML1685 MLCB637.32 3-isopropylmalate dehydratase large subunit (EC 4.2.1.33) (Alpha-IPM isomerase) (IPMI) (Isopropylmalate isomerase) 476 74.297 Strong candidate 0.4931 ProteomeLM contextual shift 0.102118134 1.0 100 1.0 1470 30 0.8045 0.9238 92.38 0.64 1.0 4.2.1.33 PATHWAY: Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 2/4. {ECO:0000255|HAMAP-Rule:MF_01026}. isomerase, cofactor ProteomeLM contextual percentile 0.49; strong pocket/AF2Bind evidence; essential-process annotation; high-confidence Boltz2 model; matched: isomerase, cofactor /main_page_ml/ML1685 2026-05-30T13:09:52Z 169 ML2321 Q9CB79 ML2321 DUF4185 domain-containing protein 336 74.275 Strong candidate 0.8878 ProteomeLM contextual shift 0.2792783 1.0 48 1.0 1044 72 0.9153 0.9576 95.76 0.0 0.8625 ProteomeLM contextual percentile 0.89; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML2321 2026-05-30T13:09:52Z 170 ML2522 Q9CD38 ML2522 Secreted protein 218 74.274 Strong candidate 0.6103 ProteomeLM contextual shift 0.118700266 1.0 38 1.0 665 22 0.7081 0.8914 89.14 0.45 1.0 PATHWAY: Cell wall biogenesis; peptidoglycan biosynthesis. {ECO:0000256|PROSITE-ProRule:PRU01373}. peptidoglycan, cell wall, transferase ProteomeLM contextual percentile 0.61; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model; matched: peptidoglycan, cell wall, transferase /main_page_ml/ML2522 2026-05-30T13:09:52Z 171 ML0603 Q7AQH2 ML0603 DNA-directed DNA polymerase (EC 2.7.7.7) 371 74.27 Strong candidate 0.6529 ProteomeLM contextual shift 0.12576503 1.0 30 1.0 1139 12 0.7424 0.7419 74.19 0.45 1.0 2.7.7.7 dna replication, replication ProteomeLM contextual percentile 0.65; strong pocket/AF2Bind evidence; functional annotation support; matched: dna replication, replication /main_page_ml/ML0603 2026-05-30T13:09:52Z 172 ML1188 Q9CC70 ML1188 HTH gntR-type domain-containing protein 86 74.182 Strong candidate 0.9536 ProteomeLM contextual shift 0.58634025 1.0 10 1.0 294 72 0.9635 0.573 57.3 0.125 0.7575 transcription ProteomeLM contextual percentile 0.95; strong pocket/AF2Bind evidence; matched: transcription /main_page_ml/ML1188 2026-05-30T13:09:52Z 173 ML2161 Q9CBD8 fadB ML2161 Fatty oxidation complex alpha subunit 714 74.173 Strong candidate 0.594 ProteomeLM contextual shift 0.116527855 1.0 144 1.0 2168 52 0.8497 0.9383 93.83 0.45 1.0 PATHWAY: Lipid metabolism; butanoate metabolism. {ECO:0000256|ARBA:ARBA00005086}.; PATHWAY: Lipid metabolism; fatty acid beta-oxidation. {ECO:0000256|ARBA:ARBA00005005}. nad, lipid metabolism, dehydrogenase ProteomeLM contextual percentile 0.59; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model; matched: nad, lipid metabolism, dehydrogenase /main_page_ml/ML2161 2026-05-30T13:09:52Z 174 ML1720 Q9CBR0 ML1720 Pyrrolo-quinoline quinone repeat domain-containing protein 364 74.089 Strong candidate 0.8897 ProteomeLM contextual shift 0.28537995 1.0 62 1.0 1137 90 0.9444 0.9323 93.23 0.0 0.8625 ProteomeLM contextual percentile 0.89; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML1720 2026-05-30T13:09:52Z 175 ML0375 P38056 alr ML0375 B229_C3_243 Alanine racemase (EC 5.1.1.1) 388 74.069 Strong candidate 0.4311 ProteomeLM contextual shift 0.09547806 1.0 114 1.0 1206 84 0.9523 0.9381 93.81 0.73 1.0 5.1.1.1 PATHWAY: Amino-acid biosynthesis; D-alanine biosynthesis; D-alanine from L-alanine: step 1/1. {ECO:0000255|HAMAP-Rule:MF_01201}. peptidoglycan, d-alanine, cofactor ProteomeLM contextual percentile 0.43; strong pocket/AF2Bind evidence; essential-process annotation; high-confidence Boltz2 model; matched: peptidoglycan, d-alanine, cofactor /main_page_ml/ML0375 2026-05-30T13:09:52Z 176 ML2535 Q9CD30 ML2535 FtsK domain-containing protein 1329 74.065 Strong candidate 0.8371 ProteomeLM contextual shift 0.19499932 1.0 176 1.0 1349 0 0.4115 0.7892 78.92 0.245 0.6975 fts ProteomeLM contextual percentile 0.84; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: fts /main_page_ml/ML2535 2026-05-30T13:09:52Z 177 ML2696 Q9CCY2 ML2696 MarR-family regulatory protein 243 74.061 Strong candidate 0.9142 ProteomeLM contextual shift 0.39594522 1.0 78 1.0 540 108 0.9904 0.594 59.4 0.125 0.8625 transcription ProteomeLM contextual percentile 0.91; strong pocket/AF2Bind evidence; matched: transcription /main_page_ml/ML2696 2026-05-30T13:09:52Z 178 ML0604 O33132 rpsT ML0604 MLCL536.06 Small ribosomal subunit protein bS20 (30S ribosomal protein S20) 86 74.036 Strong candidate 0.7939 ProteomeLM contextual shift 0.16724724 1.0 10 1.0 184 24 0.8777 0.9376 93.76 0.215 0.7575 translation, ribosome, ribosomal ProteomeLM contextual percentile 0.79; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: translation, ribosome, ribosomal /main_page_ml/ML0604 2026-05-30T13:09:52Z 179 ML2671 O53114 ctpI ML2671 MLCB1913.02 Probable cation-transporting ATPase I (EC 7.2.2.-) 1609 74.026 Strong candidate 0.6573 ProteomeLM contextual shift 0.12690158 1.0 322 1.0 0 0 0.0 0.8072 80.72 0.48 0.835 7.2.2.- ProteomeLM contextual percentile 0.66; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model /main_page_ml/ML2671 2026-05-30T13:09:52Z 180 ML0052 Q9CDD7 ML0052 FtsK domain-containing protein 597 74.016 Strong candidate 0.7657 ProteomeLM contextual shift 0.15651047 1.0 86 1.0 1851 0 0.1857 0.8693 86.93 0.245 0.8625 fts ProteomeLM contextual percentile 0.77; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: fts /main_page_ml/ML0052 2026-05-30T13:09:52Z 181 ML0071 Q9CDC7 ML0071 Peptidase 177 73.987 Strong candidate 0.8972 ProteomeLM contextual shift 0.29785395 1.0 28 1.0 359 10 0.6183 0.8959 89.59 0.0 0.8625 ProteomeLM contextual percentile 0.90; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML0071 2026-05-30T13:09:52Z 182 ML2447 Q9CB48 murB ML2447 UDP-N-acetylenolpyruvoylglucosamine reductase (EC 1.3.1.98) (UDP-N-acetylmuramate dehydrogenase) 367 73.966 Strong candidate 0.3584 ProteomeLM contextual shift 0.08715026 1.0 70 1.0 1210 218 0.9849 0.9123 91.23 0.865 1.0 1.3.1.98 PATHWAY: Cell wall biogenesis; peptidoglycan biosynthesis. cell division, peptidoglycan, cell wall, mur, dehydrogenase, reductase, cofactor ProteomeLM contextual percentile 0.36; strong pocket/AF2Bind evidence; essential-process annotation; high-confidence Boltz2 model; matched: cell division, peptidoglycan, cell wall, mur, dehydrogenase /main_page_ml/ML2447 2026-05-30T13:09:52Z 183 ML0130 Q9CD86 ML0130 Phthiotriol/phenolphthiotriol dimycocerosates methyltransferase (EC 2.1.1.-) 270 73.952 Strong candidate 0.7199 ProteomeLM contextual shift 0.14200202 1.0 54 1.0 899 178 0.9991 0.8955 89.55 0.24 1.0 2.1.1.- transferase ProteomeLM contextual percentile 0.72; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: transferase /main_page_ml/ML0130 2026-05-30T13:09:52Z 184 ML0580 Q7AQI2 ML0580 Glucose-6-phosphate dehydrogenase assembly protein OpcA 265 73.938 Strong candidate 0.9248 ProteomeLM contextual shift 0.46038806 1.0 42 1.0 819 48 0.8918 0.6569 65.69 0.0 1.0 dehydrogenase ProteomeLM contextual percentile 0.92; strong pocket/AF2Bind evidence; matched: dehydrogenase /main_page_ml/ML0580 2026-05-30T13:09:52Z 185 ML1271 Q9X7C7 trpC ML1271 MLCB1610.33 Indole-3-glycerol phosphate synthase (IGPS) (EC 4.1.1.48) 272 73.864 Strong candidate 0.5464 ProteomeLM contextual shift 0.10862707 1.0 30 1.0 878 124 0.9777 0.9342 93.42 0.52 1.0 4.1.1.48 PATHWAY: Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 4/5. isomerase, synthase ProteomeLM contextual percentile 0.55; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model; matched: isomerase, synthase /main_page_ml/ML1271 2026-05-30T13:09:52Z 186 ML1024 P46813 suhB ssyA ML1024 Inositol-1-monophosphatase (I-1-Pase) (IMPase) (Inositol-1-phosphatase) (EC 3.1.3.25) 291 73.847 Strong candidate 0.5771 ProteomeLM contextual shift 0.113526165 1.0 68 1.0 917 88 0.8864 0.905 90.5 0.48 1.0 3.1.3.25 cofactor ProteomeLM contextual percentile 0.58; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model; matched: cofactor /main_page_ml/ML1024 2026-05-30T13:09:52Z 187 ML0858 O32962 lipA ML0858 MLCB22.20 Lipoyl synthase (EC 2.8.1.8) (Lip-syn) (LS) (Lipoate synthase) (Lipoic acid synthase) (Sulfur insertion protein LipA) 314 73.84 Strong candidate 0.4887 ProteomeLM contextual shift 0.10179948 1.0 32 1.0 1040 196 0.9935 0.8935 89.35 0.64 1.0 2.8.1.8 PATHWAY: Protein modification; protein lipoylation via endogenous pathway; protein N(6)-(lipoyl)lysine from octanoyl-[acyl-carrier-protein]: step 2/2. {ECO:0000255|HAMAP-Rule:MF_00206}. synthase, cofactor ProteomeLM contextual percentile 0.49; strong pocket/AF2Bind evidence; essential-process annotation; high-confidence Boltz2 model; matched: synthase, cofactor /main_page_ml/ML0858 2026-05-30T13:09:52Z 188 ML0213 O69538 tilS ML0213 MLCB2548.18c tRNA(Ile)-lysidine synthase (EC 6.3.4.19) (tRNA(Ile)-2-lysyl-cytidine synthase) (tRNA(Ile)-lysidine synthetase) 323 73.789 Strong candidate 0.5827 ProteomeLM contextual shift 0.114759274 1.0 60 1.0 1043 148 0.9877 0.8795 87.95 0.48 1.0 6.3.4.19 synthetase, synthase ProteomeLM contextual percentile 0.58; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model; matched: synthetase, synthase /main_page_ml/ML0213 2026-05-30T13:09:52Z 189 ML0986 Q9CCC1 ML0986 Signal transduction histidine kinase 67 73.778 Strong candidate 0.8772 ProteomeLM contextual shift 0.25216475 1.0 10 1.0 242 2 0.523 0.9126 91.26 0.0 0.895 kinase ProteomeLM contextual percentile 0.88; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: kinase /main_page_ml/ML0986 2026-05-30T13:09:52Z 190 ML0229 Q7AQL2 ML0229 Oxidoreductase 309 73.776 Strong candidate 0.8841 ProteomeLM contextual shift 0.2659921 1.0 38 1.0 1058 262 0.985 0.7833 78.33 0.0 1.0 oxidoreductase, reductase ProteomeLM contextual percentile 0.88; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: oxidoreductase, reductase /main_page_ml/ML0229 2026-05-30T13:09:52Z 191 ML0925 Q9CCD8 glnA ML0925 Glutamine synthetase (EC 6.3.1.2) 478 73.767 Strong candidate 0.5727 ProteomeLM contextual shift 0.11273671 1.0 99 1.0 975 38 0.7742 0.9124 91.24 0.48 1.0 6.3.1.2 synthetase, cofactor ProteomeLM contextual percentile 0.57; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model; matched: synthetase, cofactor /main_page_ml/ML0925 2026-05-30T13:09:52Z 192 ML1519 Q9CBW0 thyA ML1519 Thymidylate synthase (TS) (TSase) (EC 2.1.1.45) 266 73.763 Strong candidate 0.4436 ProteomeLM contextual shift 0.0970115 1.0 72 1.0 857 118 0.9936 0.9536 95.36 0.685 1.0 2.1.1.45 PATHWAY: Pyrimidine metabolism; dTTP biosynthesis. {ECO:0000255|HAMAP-Rule:MF_00008}. folate, synthase ProteomeLM contextual percentile 0.44; strong pocket/AF2Bind evidence; essential-process annotation; high-confidence Boltz2 model; matched: folate, synthase /main_page_ml/ML1519 2026-05-30T13:09:52Z 193 ML1572 Q9CBV0 ML1572 PglZ domain-containing protein 132 73.729 Strong candidate 0.9586 ProteomeLM contextual shift 0.6078572 1.0 14 1.0 327 126 0.9889 0.6551 65.51 0.0 0.8625 ProteomeLM contextual percentile 0.96; strong pocket/AF2Bind evidence /main_page_ml/ML1572 2026-05-30T13:09:52Z 194 ML0938 Q9CCD4 ML0938 Uncharacterized protein 98 73.719 Strong candidate 0.958 ProteomeLM contextual shift 0.60705864 1.0 14 1.0 224 56 0.9532 0.7613 76.13 0.0 0.7575 ProteomeLM contextual percentile 0.96; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML0938 2026-05-30T13:09:52Z 195 ML0886 Q7AQE2 ML0886 GDP-mannose-dependent alpha-(1-6)-phosphatidylinositol monomannoside mannosyltransferase (EC 2.4.1.346) (Alpha-D-mannose-alpha-(1-6)-phosphatidylmyo-inositol-mannosyltransferase) (Alpha-mannosyltransferase) (Guanosine diphosphomannose-phosphatidyl-inositol alpha-mannosyltransferase) (Phosphatidylinositol alpha-mannosyltransferase) 384 73.678 Strong candidate 0.5144 ProteomeLM contextual shift 0.10431116 1.0 38 1.0 832 128 0.9735 0.9374 93.74 0.565 1.0 2.4.1.346 PATHWAY: Lipid metabolism. {ECO:0000256|ARBA:ARBA00005189}.; PATHWAY: Phospholipid metabolism; phosphatidylinositol metabolism. {ECO:0000256|ARBA:ARBA00060651}. lipid metabolism, transferase ProteomeLM contextual percentile 0.51; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model; matched: lipid metabolism, transferase /main_page_ml/ML0886 2026-05-30T13:09:52Z 196 ML1511 Q9CBW6 cobB ML1511 NAD-dependent protein deacylase (EC 2.3.1.286) (Regulatory protein SIR2 homolog) 237 73.639 Strong candidate 0.5363 ProteomeLM contextual shift 0.10736926 1.0 42 1.0 773 124 0.9928 0.9367 93.67 0.525 1.0 2.3.1.286 nad, cofactor ProteomeLM contextual percentile 0.54; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model; matched: nad, cofactor /main_page_ml/ML1511 2026-05-30T13:09:52Z 197 ML1075 Q9CCA7 ML1075 Putative O-methyltransferase ML1075 (EC 2.1.1.-) 224 73.636 Strong candidate 0.6335 ProteomeLM contextual shift 0.12208822 1.0 64 1.0 483 70 0.9643 0.9265 92.65 0.36 1.0 2.1.1.- transferase ProteomeLM contextual percentile 0.63; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model; matched: transferase /main_page_ml/ML1075 2026-05-30T13:09:52Z 198 ML2467 Q9CB36 ML2467 Short-chain Z-isoprenyl diphosphate synthase (EC 2.5.1.68) ((2Z,6E)-farnesyl diphosphate synthase) (Z-FPP synthase) (Z-isoprenyl diphosphate synthase) 262 73.607 Strong candidate 0.4041 ProteomeLM contextual shift 0.09289799 1.0 78 1.0 528 8 0.625 0.8962 89.62 0.775 1.0 2.5.1.68 PATHWAY: Phospholipid metabolism; decaprenyl phosphate biosynthesis. peptidoglycan, cell wall, lipid metabolism, synthase, cofactor ProteomeLM contextual percentile 0.40; strong pocket/AF2Bind evidence; essential-process annotation; high-confidence Boltz2 model; matched: peptidoglycan, cell wall, lipid metabolism, synthase, cofactor /main_page_ml/ML2467 2026-05-30T13:09:52Z 199 ML0244 Q9CD49 pth ML0244 Peptidyl-tRNA hydrolase (Pth) (EC 3.1.1.29) 199 73.605 Strong candidate 0.515 ProteomeLM contextual shift 0.10434197 1.0 42 1.0 617 40 0.7991 0.9178 91.78 0.57 1.0 3.1.1.29 ribosome, aminoacyl-trna, hydrolase ProteomeLM contextual percentile 0.52; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model; matched: ribosome, aminoacyl-trna, hydrolase /main_page_ml/ML0244 2026-05-30T13:09:52Z 200 ML0840 Q7AQF3 ML0840 Thioester domain-containing protein 434 73.595 Strong candidate 0.9079 ProteomeLM contextual shift 0.3647328 1.0 32 1.0 1362 0 0.3965 0.8194 81.94 0.0 0.8625 ProteomeLM contextual percentile 0.91; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML0840 2026-05-30T13:09:52Z 201 ML1137 P45830 wecA rfe ML1137 Decaprenyl-phosphate N-acetylglucosaminephosphotransferase (EC 2.7.8.35) (Decaprenyl-phosphate GlcNAc-1-phosphate transferase) (Decaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphate transferase) (UDP-GlcNAc:decaprenyl-phosphate GlcNAc-1-phosphate transferase) (UDP-N-acetylglucosamine--decaprenyl-phosphate N-acetylglucosaminephosphotransferase) 398 73.589 Strong candidate 0.5457 ProteomeLM contextual shift 0.108498916 1.0 76 1.0 1204 14 0.6895 0.8188 81.88 0.565 1.0 2.7.8.35 PATHWAY: Cell wall biogenesis; cell wall polysaccharide biosynthesis. cell wall, transferase, cofactor ProteomeLM contextual percentile 0.55; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model; matched: cell wall, transferase, cofactor /main_page_ml/ML1137 2026-05-30T13:09:52Z 202 ML2114 Q9CBE3 ML2114 Antitoxin 56 73.577 Strong candidate 0.9793 ProteomeLM contextual shift 0.7693561 1.0 10 1.0 193 10 0.7223 0.6725 67.25 0.0 0.7575 ProteomeLM contextual percentile 0.98; strong pocket/AF2Bind evidence /main_page_ml/ML2114 2026-05-30T13:09:52Z 203 ML2355 Q49933 ML2355 Polyketide synthase 2201 73.542 Strong candidate 0.7794 ProteomeLM contextual shift 0.16083133 1.0 221 1.0 0 0 0.0 0.8011 80.11 0.245 0.835 cell wall, oxidoreductase, reductase, synthase ProteomeLM contextual percentile 0.78; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: cell wall, oxidoreductase, reductase, synthase /main_page_ml/ML2355 2026-05-30T13:09:52Z 204 ML0247 Q9CD46 arsC ML0247 Arsenate reductase 104 73.468 Strong candidate 0.9348 ProteomeLM contextual shift 0.50461453 1.0 22 1.0 346 68 0.9669 0.6799 67.99 0.0 0.895 reductase ProteomeLM contextual percentile 0.93; strong pocket/AF2Bind evidence; matched: reductase /main_page_ml/ML0247 2026-05-30T13:09:52Z 205 ML0319 Q9ZBM7 lpqE ML0319 MLCB1450.02 Putative lipoprotein LpqE 183 73.443 Strong candidate 0.8891 ProteomeLM contextual shift 0.28194228 1.0 14 1.0 576 14 0.8067 0.71 71.0 0.08 0.8625 ProteomeLM contextual percentile 0.89; strong pocket/AF2Bind evidence /main_page_ml/ML0319 2026-05-30T13:09:52Z 206 ML1469 Q9CBZ0 ndk ML1469 Nucleoside diphosphate kinase (NDK) (NDP kinase) (EC 2.7.4.6) (Nucleoside-2-P kinase) 136 73.435 Strong candidate 0.552 ProteomeLM contextual shift 0.10951339 1.0 76 1.0 469 122 0.98 0.9514 95.14 0.48 1.0 2.7.4.6 kinase, cofactor ProteomeLM contextual percentile 0.55; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model; matched: kinase, cofactor /main_page_ml/ML1469 2026-05-30T13:09:52Z 207 ML0542 Q9CCQ6 rpoZ ML0542 DNA-directed RNA polymerase subunit omega (RNAP omega subunit) (EC 2.7.7.6) (RNA polymerase omega subunit) (Transcriptase subunit omega) 110 73.425 Strong candidate 0.6873 ProteomeLM contextual shift 0.13164817 1.0 10 1.0 363 26 0.9656 0.6418 64.18 0.45 0.895 2.7.7.6 rna polymerase, transcription ProteomeLM contextual percentile 0.69; strong pocket/AF2Bind evidence; functional annotation support; matched: rna polymerase, transcription /main_page_ml/ML0542 2026-05-30T13:09:52Z 208 ML0758 Q9CCK2 fbiB ML0758 Bifunctional F420 biosynthesis protein FbiB [Includes: Coenzyme F420:L-glutamate ligase (EC 6.3.2.31) (EC 6.3.2.34) (Coenzyme F420-0:L-glutamate ligase) (Coenzyme F420-1:gamma-L-glutamate ligase); Dehydro-coenzyme F420-0 reductase (EC 1.3.8.17)] 457 73.352 Strong candidate 0.4524 ProteomeLM contextual shift 0.09785853 1.0 125 1.0 1398 54 0.789 0.8818 88.18 0.685 1.0 1.3.8.17; 6.3.2.31; 6.3.2.34 PATHWAY: Cofactor biosynthesis; coenzyme F420 biosynthesis. {ECO:0000255|HAMAP-Rule:MF_01259}. cofactor biosynthesis, enzyme, ligase, oxidoreductase ProteomeLM contextual percentile 0.45; strong pocket/AF2Bind evidence; essential-process annotation; high-confidence Boltz2 model; matched: cofactor biosynthesis, enzyme, ligase, oxidoreductase /main_page_ml/ML0758 2026-05-30T13:09:52Z 209 ML0050 O33084 esxB ML0050 MLCB628.13c ESAT-6-like protein EsxB 100 73.326 Strong candidate 0.8741 ProteomeLM contextual shift 0.24750772 1.0 30 1.0 360 0 0.484 0.8559 85.59 0.08 0.7575 ProteomeLM contextual percentile 0.87; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML0050 2026-05-30T13:09:52Z 210 ML0177 Q7AQN0 moaB ML0177 Molybdenum cofactor biosynthesis protein 181 73.322 Strong candidate 0.6892 ProteomeLM contextual shift 0.13211295 1.0 110 1.0 375 26 0.8077 0.8499 84.99 0.285 1.0 PATHWAY: Cofactor biosynthesis; molybdopterin biosynthesis. {ECO:0000256|ARBA:ARBA00005046}. cofactor biosynthesis, cofactor ProteomeLM contextual percentile 0.69; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: cofactor biosynthesis, cofactor /main_page_ml/ML0177 2026-05-30T13:09:52Z 211 ML2151 Q7APY1 ML2151 Resuscitation-promoting factor RpfA 174 73.309 Strong candidate 0.8791 ProteomeLM contextual shift 0.2541089 1.0 20 1.0 555 66 0.8719 0.5942 59.42 0.08 1.0 hydrolase ProteomeLM contextual percentile 0.88; strong pocket/AF2Bind evidence; matched: hydrolase /main_page_ml/ML2151 2026-05-30T13:09:52Z 212 ML0160 Q7AQN4 purN ML0160 Phosphoribosylglycinamide formyltransferase (EC 2.1.2.2) (5'-phosphoribosylglycinamide transformylase) (GAR transformylase) (GART) 215 73.309 Strong candidate 0.4386 ProteomeLM contextual shift 0.09659244 1.0 30 1.0 691 92 0.9671 0.9258 92.58 0.685 1.0 2.1.2.2 PATHWAY: Purine metabolism; IMP biosynthesis via de novo pathway; N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide from N(1)-(5-phospho-D-ribosyl)glycinamide (10-formyl THF route): step 1/1. {ECO:0000256|ARBA:ARBA00005054, ECO:0000256|HAMAP-Rule:MF_01930}. folate, transferase ProteomeLM contextual percentile 0.44; strong pocket/AF2Bind evidence; essential-process annotation; high-confidence Boltz2 model; matched: folate, transferase /main_page_ml/ML0160 2026-05-30T13:09:52Z 213 ML1028 Q49992 dut ML1028 Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase) (EC 3.6.1.23) (dUTP pyrophosphatase) 154 73.296 Strong candidate 0.4962 ProteomeLM contextual shift 0.10256286 1.0 42 1.0 490 56 0.8869 0.8128 81.28 0.64 1.0 3.6.1.23 PATHWAY: Pyrimidine metabolism; dUMP biosynthesis; dUMP from dCTP (dUTP route): step 2/2. {ECO:0000255|HAMAP-Rule:MF_00116}. hydrolase, cofactor ProteomeLM contextual percentile 0.50; strong pocket/AF2Bind evidence; essential-process annotation; high-confidence Boltz2 model; matched: hydrolase, cofactor /main_page_ml/ML1028 2026-05-30T13:09:52Z 214 ML2063 Q7APZ8 ML2063 Transcriptional regulator BlaI 142 73.249 Strong candidate 0.8296 ProteomeLM contextual shift 0.18798934 1.0 14 1.0 468 84 0.931 0.8089 80.89 0.125 0.8625 transcription ProteomeLM contextual percentile 0.83; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: transcription /main_page_ml/ML2063 2026-05-30T13:09:52Z 215 ML0772 Q9CCJ3 tmk ML0772 Thymidylate kinase (EC 2.7.4.9) (dTMP kinase) 210 73.237 Strong candidate 0.6228 ProteomeLM contextual shift 0.12065562 1.0 26 1.0 645 30 0.9563 0.9239 92.39 0.36 1.0 2.7.4.9 kinase ProteomeLM contextual percentile 0.62; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model; matched: kinase /main_page_ml/ML0772 2026-05-30T13:09:52Z 216 ML2497 Q9CB22 ML2497 TetR-family transcriptional regulator 157 73.206 Strong candidate 0.8465 ProteomeLM contextual shift 0.20264451 1.0 16 1.0 539 136 0.9954 0.9054 90.54 0.045 0.8625 transcription ProteomeLM contextual percentile 0.85; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: transcription /main_page_ml/ML2497 2026-05-30T13:09:52Z 217 ML0949 Q9CCD1 ML0949 HTH tetR-type domain-containing protein 137 73.199 Strong candidate 0.9398 ProteomeLM contextual shift 0.5218972 1.0 30 1.0 460 98 0.861 0.5079 50.79 0.08 0.8625 ProteomeLM contextual percentile 0.94; strong pocket/AF2Bind evidence /main_page_ml/ML0949 2026-05-30T13:09:52Z 218 ML0283 Q9CCX3 ML0283 Cation-efflux transporter component 268 73.179 Strong candidate 0.8885 ProteomeLM contextual shift 0.27976888 1.0 58 1.0 872 136 0.955 0.6857 68.57 0.08 0.8625 ProteomeLM contextual percentile 0.89; strong pocket/AF2Bind evidence /main_page_ml/ML0283 2026-05-30T13:09:52Z 219 ML0757 Q9CCK3 ML0757 Uncharacterized protein 230 73.163 Strong candidate 0.859 ProteomeLM contextual shift 0.21714325 1.0 18 1.0 705 30 0.8381 0.9472 94.72 0.0 0.8625 ProteomeLM contextual percentile 0.86; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML0757 2026-05-30T13:09:52Z 220 ML0139 Q9CD78 mas ML0139 Mycocerosic synthase 2116 73.154 Strong candidate 0.7632 ProteomeLM contextual shift 0.15482089 1.0 182 1.0 0 0 0.0 0.8194 81.94 0.245 0.835 cell wall, oxidoreductase, reductase, synthase ProteomeLM contextual percentile 0.76; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: cell wall, oxidoreductase, reductase, synthase /main_page_ml/ML0139 2026-05-30T13:09:52Z 221 ML0447 Q9CCU2 ML0447 Cytochrome P450 158 73.142 Strong candidate 0.9129 ProteomeLM contextual shift 0.39253357 1.0 28 1.0 557 166 0.9921 0.459 45.9 0.08 1.0 oxidoreductase, reductase ProteomeLM contextual percentile 0.91; strong pocket/AF2Bind evidence; matched: oxidoreductase, reductase /main_page_ml/ML0447 2026-05-30T13:09:52Z 222 ML0392 Q49736 ML0392 B1620_F1_30 Uncharacterized glycosyl hydrolase ML0392 (EC 3.2.1.-) 792 73.105 Strong candidate 0.6328 ProteomeLM contextual shift 0.122058555 1.0 196 1.0 2436 0 0.4 0.9506 95.06 0.36 0.925 3.2.1.- transferase, hydrolase ProteomeLM contextual percentile 0.63; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model; matched: transferase, hydrolase /main_page_ml/ML0392 2026-05-30T13:09:52Z 223 ML0537 Q9CCR1 pyrF ML0537 Orotidine 5'-phosphate decarboxylase (EC 4.1.1.23) (OMP decarboxylase) (OMPDCase) (OMPdecase) 282 73.101 Strong candidate 0.4599 ProteomeLM contextual shift 0.098955154 1.0 52 1.0 884 76 0.9415 0.9205 92.05 0.64 1.0 4.1.1.23 PATHWAY: Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 2/2. ProteomeLM contextual percentile 0.46; strong pocket/AF2Bind evidence; essential-process annotation; high-confidence Boltz2 model /main_page_ml/ML0537 2026-05-30T13:09:52Z 224 ML0755 Q9CCK5 ML0755 NUDIX hydrolase 86 73.094 Strong candidate 0.906 ProteomeLM contextual shift 0.3610603 1.0 18 1.0 316 116 0.9732 0.7433 74.33 0.0 0.895 hydrolase ProteomeLM contextual percentile 0.91; strong pocket/AF2Bind evidence; matched: hydrolase /main_page_ml/ML0755 2026-05-30T13:09:52Z 225 ML2402 O07137 echA8 ML2402 MLCB1306.05c Probable enoyl-CoA hydratase echA8 (EC 4.2.1.17) 257 73.09 Strong candidate 0.6284 ProteomeLM contextual shift 0.12133466 1.0 98 1.0 848 154 0.9547 0.8895 88.95 0.36 1.0 4.2.1.17 isomerase ProteomeLM contextual percentile 0.63; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model; matched: isomerase /main_page_ml/ML2402 2026-05-30T13:09:52Z 226 ML1067 Q7AQ95 ML1067 DUF3117 domain-containing protein 75 73.085 Strong candidate 0.963 ProteomeLM contextual shift 0.641023 1.0 14 1.0 253 56 0.9507 0.6804 68.04 0.0 0.7575 ProteomeLM contextual percentile 0.96; strong pocket/AF2Bind evidence /main_page_ml/ML1067 2026-05-30T13:09:52Z 227 ML1301 P46726 cysQ ML1301 B2126_C3_229 3'-phosphoadenosine 5'-phosphate phosphatase (PAP phosphatase) (EC 3.1.3.7) (3'(2'),5'-bisphosphate nucleotidase) (3'(2'),5-bisphosphonucleoside 3'(2')-phosphohydrolase) (D-fructose-1,6-bisphosphate 1-phosphohydrolase) (DPNPase) (Fructose-1,6-bisphosphatase) (FBPase) (EC 3.1.3.11) (Inositol-1-monophosphatase) (I-1-Pase) (IMPase) (EC 3.1.3.25) (Inositol-1-phosphatase) 271 73.083 Strong candidate 0.4637 ProteomeLM contextual shift 0.09930466 1.0 22 1.0 544 4 0.6972 0.9055 90.55 0.64 1.0 3.1.3.11; 3.1.3.25; 3.1.3.7 PATHWAY: Sulfur metabolism; sulfate assimilation. hydrolase, cofactor ProteomeLM contextual percentile 0.46; strong pocket/AF2Bind evidence; essential-process annotation; high-confidence Boltz2 model; matched: hydrolase, cofactor /main_page_ml/ML1301 2026-05-30T13:09:52Z 228 ML0853 O32967 rpsO ML0853 MLCB22.28c Small ribosomal subunit protein uS15 (30S ribosomal protein S15) 89 73.078 Strong candidate 0.7694 ProteomeLM contextual shift 0.15774429 1.0 10 1.0 287 40 0.8248 0.9273 92.73 0.215 0.7575 translation, ribosome, ribosomal ProteomeLM contextual percentile 0.77; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: translation, ribosome, ribosomal /main_page_ml/ML0853 2026-05-30T13:09:52Z 229 ML2584 O69492 ML2584 MLCB1883.02c Uncharacterized methyltransferase ML2584 (EC 2.1.1.-) 269 73.027 Strong candidate 0.6999 ProteomeLM contextual shift 0.13647397 1.0 62 1.0 878 142 0.9919 0.8731 87.31 0.24 1.0 2.1.1.- transferase ProteomeLM contextual percentile 0.70; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: transferase /main_page_ml/ML2584 2026-05-30T13:09:52Z 230 ML0098 Q05868 mpt51 ML0098 MPT51 antigen 301 73.006 Strong candidate 0.7807 ProteomeLM contextual shift 0.16172755 1.0 16 1.0 944 2 0.5761 0.9082 90.82 0.08 1.0 transferase ProteomeLM contextual percentile 0.78; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: transferase /main_page_ml/ML0098 2026-05-30T13:09:52Z 231 ML1086 Q9CCA3 ML1086 Probable solute-binding transport lipoprotein 468 73.0 Strong candidate 0.8189 ProteomeLM contextual shift 0.17857641 1.0 43 1.0 1428 48 0.8621 0.9113 91.13 0.08 0.8625 ProteomeLM contextual percentile 0.82; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML1086 2026-05-30T13:09:52Z 232 ML2707 Q9CCX7 parA ML2707 Cell division protein 351 72.986 Strong candidate 0.8358 ProteomeLM contextual shift 0.19416445 1.0 86 1.0 1082 18 0.8287 0.7606 76.06 0.125 0.8625 cell division ProteomeLM contextual percentile 0.84; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: cell division /main_page_ml/ML2707 2026-05-30T13:09:52Z 233 ML1821 Q9CBL0 ML1821 Uncharacterized protein 117 72.985 Strong candidate 0.985 ProteomeLM contextual shift 0.84449565 1.0 22 1.0 423 144 0.9796 0.5936 59.36 0.0 0.7575 ProteomeLM contextual percentile 0.98; strong pocket/AF2Bind evidence /main_page_ml/ML1821 2026-05-30T13:09:52Z 234 ML2395 P41484 ag36 pra ML2395 Proline-rich antigen (Pra) (36 kDa antigen) 249 72.974 Strong candidate 0.901 ProteomeLM contextual shift 0.31368345 1.0 28 1.0 769 44 0.9093 0.6214 62.14 0.08 0.8625 ProteomeLM contextual percentile 0.90; strong pocket/AF2Bind evidence /main_page_ml/ML2395 2026-05-30T13:09:52Z 235 ML2265 Q9CBB3 ML2265 Uncharacterized protein 73 72.97 Strong candidate 0.9887 ProteomeLM contextual shift 0.8916063 1.0 18 1.0 292 146 0.9811 0.579 57.9 0.0 0.7575 ProteomeLM contextual percentile 0.99; strong pocket/AF2Bind evidence /main_page_ml/ML2265 2026-05-30T13:09:52Z 236 ML1974 Q9CBH5 ML1974 Transporter 572 72.967 Strong candidate 0.8684 ProteomeLM contextual shift 0.23858203 1.0 126 1.0 1744 16 0.8294 0.7347 73.47 0.08 0.8625 ProteomeLM contextual percentile 0.87; strong pocket/AF2Bind evidence /main_page_ml/ML1974 2026-05-30T13:09:52Z 237 ML1105 Q9CC91 udgB ML1105 Type-5 uracil-DNA glycosylase (EC 3.2.2.-) 229 72.927 Strong candidate 0.6065 ProteomeLM contextual shift 0.11816398 1.0 42 1.0 727 80 0.981 0.9498 94.98 0.36 1.0 3.2.2.- ProteomeLM contextual percentile 0.61; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model /main_page_ml/ML1105 2026-05-30T13:09:52Z 238 ML1014 Q59531 ML1014 RNA polymerase sigma factor 319 72.883 Strong candidate 0.8534 ProteomeLM contextual shift 0.21146592 1.0 38 1.0 975 36 0.9658 0.599 59.9 0.17 0.8625 rna polymerase, transcription ProteomeLM contextual percentile 0.85; strong pocket/AF2Bind evidence; matched: rna polymerase, transcription /main_page_ml/ML1014 2026-05-30T13:09:52Z 239 ML1607 O33024 ML1607 MLCB250.49 UPF0102 protein ML1607 96 72.881 Strong candidate 0.9561 ProteomeLM contextual shift 0.5991687 1.0 14 1.0 234 84 0.9835 0.5242 52.42 0.08 0.7575 ProteomeLM contextual percentile 0.96; strong pocket/AF2Bind evidence /main_page_ml/ML1607 2026-05-30T13:09:52Z 240 ML0685 Q7AQG1 ML0685 Hydrolase 303 72.877 Strong candidate 0.7982 ProteomeLM contextual shift 0.16887471 1.0 64 1.0 641 70 0.9853 0.8338 83.38 0.08 1.0 hydrolase ProteomeLM contextual percentile 0.80; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: hydrolase /main_page_ml/ML0685 2026-05-30T13:09:52Z 241 ML2680 P46394 dnaB ML2680 MLCB1913.16c Replicative DNA helicase DnaB (EC 5.6.2.3) (DNA 5'-3' helicase DnaB) [Cleaved into: Mle DnaB intein (EC 3.1.-.-)] 604 72.865 Strong candidate 0.5476 ProteomeLM contextual shift 0.108808406 1.0 110 1.0 1837 10 0.8317 0.7298 72.98 0.57 1.0 3.1.-.-; 5.6.2.3 dna replication, replication ProteomeLM contextual percentile 0.55; strong pocket/AF2Bind evidence; functional annotation support; matched: dna replication, replication /main_page_ml/ML2680 2026-05-30T13:09:52Z 242 ML2669 Q7APS4 ML2669 Uncharacterized protein 106 72.836 Strong candidate 0.9812 ProteomeLM contextual shift 0.7782346 1.0 14 1.0 348 60 0.9385 0.5919 59.19 0.0 0.7575 ProteomeLM contextual percentile 0.98; strong pocket/AF2Bind evidence /main_page_ml/ML2669 2026-05-30T13:09:52Z 243 ML1919 Q9CBJ1 ML1919 Carbonic anhydrase (EC 4.2.1.1) (Carbonate dehydratase) 213 72.766 Strong candidate 0.5445 ProteomeLM contextual shift 0.10833627 1.0 84 1.0 673 68 0.9246 0.9109 91.09 0.48 1.0 4.2.1.1 cofactor ProteomeLM contextual percentile 0.54; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model; matched: cofactor /main_page_ml/ML1919 2026-05-30T13:09:52Z 244 ML1695 O33113 ilvH ilvN ML1695 MLCB637.21 Acetolactate synthase small subunit (EC 2.2.1.6) (Acetohydroxy-acid synthase small subunit) (AHAS) (ALS) 169 72.76 Strong candidate 0.5244 ProteomeLM contextual shift 0.105843164 1.0 20 1.0 545 76 0.9186 0.9005 90.05 0.52 1.0 2.2.1.6 PATHWAY: Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 1/4.; PATHWAY: Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 1/4. synthase ProteomeLM contextual percentile 0.52; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model; matched: synthase /main_page_ml/ML1695 2026-05-30T13:09:52Z 245 ML2030 Q9CBF8 ML2030 Resuscitation-promoting factor core lysozyme-like domain-containing protein 157 72.754 Strong candidate 0.8396 ProteomeLM contextual shift 0.19717552 1.0 22 1.0 327 26 0.8338 0.6768 67.68 0.08 1.0 hydrolase ProteomeLM contextual percentile 0.84; strong pocket/AF2Bind evidence; matched: hydrolase /main_page_ml/ML2030 2026-05-30T13:09:52Z 246 ML1829 Q9CBK9 ML1829 Uncharacterized protein 125 72.753 Strong candidate 0.9612 ProteomeLM contextual shift 0.6315152 1.0 20 1.0 433 116 0.9905 0.5487 54.87 0.0 0.8625 ProteomeLM contextual percentile 0.96; strong pocket/AF2Bind evidence /main_page_ml/ML1829 2026-05-30T13:09:52Z 247 ML2304 Q9CB89 ML2304 Uncharacterized protein 174 72.748 Strong candidate 0.8672 ProteomeLM contextual shift 0.23405284 1.0 38 1.0 354 12 0.8016 0.8772 87.72 0.0 0.8625 ProteomeLM contextual percentile 0.87; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML2304 2026-05-30T13:09:52Z 248 ML2189 Q50046 pstB phoT ML2189 Phosphate import ATP-binding protein PstB (EC 7.3.2.1) (ABC phosphate transporter) (Phosphate-transporting ATPase) 258 72.734 Strong candidate 0.5414 ProteomeLM contextual shift 0.10789889 1.0 121 1.0 532 32 0.7789 0.9187 91.87 0.48 1.0 7.3.2.1 ProteomeLM contextual percentile 0.54; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model /main_page_ml/ML2189 2026-05-30T13:09:52Z 249 ML1990 Q9CBG6 ML1990 Integral membrane protein 80 72.731 Strong candidate 0.9881 ProteomeLM contextual shift 0.88956094 1.0 8 1.0 260 40 0.8076 0.5572 55.72 0.0 0.7575 ProteomeLM contextual percentile 0.99; strong pocket/AF2Bind evidence /main_page_ml/ML1990 2026-05-30T13:09:52Z 250 ML0868 O32953 cobT ML0868 MLCB22.08 Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase (NN:DBI PRT) (EC 2.4.2.21) (N(1)-alpha-phosphoribosyltransferase) 351 72.724 Strong candidate 0.443 ProteomeLM contextual shift 0.09685211 1.0 34 1.0 1095 84 0.9758 0.942 94.2 0.64 1.0 2.4.2.21 PATHWAY: Nucleoside biosynthesis; alpha-ribazole biosynthesis; alpha-ribazole from 5,6-dimethylbenzimidazole: step 1/2. transferase ProteomeLM contextual percentile 0.44; strong pocket/AF2Bind evidence; essential-process annotation; high-confidence Boltz2 model; matched: transferase /main_page_ml/ML0868 2026-05-30T13:09:52Z 251 ML0575 Q9CCN6 ML0575 Uncharacterized protein 72 72.72 Strong candidate 0.9856 ProteomeLM contextual shift 0.8539509 1.0 12 1.0 230 28 0.9076 0.565 56.5 0.0 0.7575 ProteomeLM contextual percentile 0.99; strong pocket/AF2Bind evidence /main_page_ml/ML0575 2026-05-30T13:09:52Z 252 ML1115 Q9CC87 lprB ML1115 Putative lipoprotein LprB 188 72.69 Strong candidate 0.8515 ProteomeLM contextual shift 0.20992185 1.0 16 1.0 584 40 0.7575 0.7662 76.62 0.08 0.8625 ProteomeLM contextual percentile 0.85; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML1115 2026-05-30T13:09:52Z 253 ML1175 P52063 ML1175 B1549_C2_213 MLCB1701.01 dITP/XTP pyrophosphatase (EC 3.6.1.66) (Non-canonical purine NTP pyrophosphatase) (Non-standard purine NTP pyrophosphatase) (Nucleoside-triphosphate diphosphatase) (Nucleoside-triphosphate pyrophosphatase) (NTPase) 208 72.679 Strong candidate 0.5564 ProteomeLM contextual shift 0.10996944 1.0 54 1.0 692 64 0.9457 0.8605 86.05 0.48 1.0 3.6.1.66 cofactor ProteomeLM contextual percentile 0.56; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model; matched: cofactor /main_page_ml/ML1175 2026-05-30T13:09:52Z 254 ML1274 Q9CC52 lgt ML1274 Phosphatidylglycerol--prolipoprotein diacylglyceryl transferase (EC 2.5.1.145) 330 72.664 Strong candidate 0.4975 ProteomeLM contextual shift 0.102605514 1.0 56 1.0 1039 98 0.9763 0.7451 74.51 0.64 1.0 2.5.1.145 PATHWAY: Protein modification; lipoprotein biosynthesis (diacylglyceryl transfer). {ECO:0000255|HAMAP-Rule:MF_01147}. transferase ProteomeLM contextual percentile 0.50; strong pocket/AF2Bind evidence; essential-process annotation; matched: transferase /main_page_ml/ML1274 2026-05-30T13:09:52Z 255 ML0271 Q9CCX5 ML0271 Membrane protein 123 72.657 Strong candidate 0.8709 ProteomeLM contextual shift 0.2413247 1.0 17 1.0 404 70 0.9182 0.8549 85.49 0.0 0.8625 ProteomeLM contextual percentile 0.87; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML0271 2026-05-30T13:09:52Z 256 ML2045 Q9CBF3 ML2045 Uncharacterized protein 85 72.65 Strong candidate 0.916 ProteomeLM contextual shift 0.40939224 1.0 14 1.0 302 94 0.961 0.8014 80.14 0.0 0.7575 ProteomeLM contextual percentile 0.92; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML2045 2026-05-30T13:09:52Z 257 ML2098 Q50103 mntH bcg ML2098 Divalent metal cation transporter MntH 426 72.648 Strong candidate 0.8195 ProteomeLM contextual shift 0.1805073 1.0 75 1.0 1338 0 0.4129 0.8739 87.39 0.08 0.8625 ProteomeLM contextual percentile 0.82; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML2098 2026-05-30T13:09:52Z 258 ML2629 Q7APS8 ML2629 Coenzyme Q-binding protein COQ10 START domain-containing protein 156 72.642 Strong candidate 0.8315 ProteomeLM contextual shift 0.18926847 1.0 36 1.0 550 164 0.9955 0.8541 85.41 0.0 1.0 enzyme ProteomeLM contextual percentile 0.83; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: enzyme /main_page_ml/ML2629 2026-05-30T13:09:52Z 259 ML0410 Q49724 ML0410 PE-family protein 100 72.606 Strong candidate 0.8979 ProteomeLM contextual shift 0.30105358 1.0 8 1.0 313 26 0.9155 0.8606 86.06 0.0 0.7575 ProteomeLM contextual percentile 0.90; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML0410 2026-05-30T13:09:52Z 260 ML0074 Q9CDC5 glpQ ML0074 Glycerophosphoryl diester phosphodiesterase (EC 3.1.4.46) 271 72.605 Strong candidate 0.6761 ProteomeLM contextual shift 0.1301721 1.0 44 1.0 838 50 0.8758 0.9143 91.43 0.24 1.0 3.1.4.46 ProteomeLM contextual percentile 0.68; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML0074 2026-05-30T13:09:52Z 261 ML0776 Q9CCI9 ML0776 ML0776 protein 85 72.564 Strong candidate 0.9743 ProteomeLM contextual shift 0.7037281 1.0 12 1.0 330 150 0.9889 0.5888 58.88 0.0 0.7575 ProteomeLM contextual percentile 0.97; strong pocket/AF2Bind evidence /main_page_ml/ML0776 2026-05-30T13:09:52Z 262 ML2288 Q9CBA0 ML2288 Uncharacterized protein 74 72.539 Strong candidate 0.9875 ProteomeLM contextual shift 0.86339194 1.0 14 1.0 247 50 0.8323 0.5403 54.03 0.0 0.7575 ProteomeLM contextual percentile 0.99; strong pocket/AF2Bind evidence /main_page_ml/ML2288 2026-05-30T13:09:52Z 263 ML0232 Q9CD56 coaX ML0232 Type III pantothenate kinase (EC 2.7.1.33) (PanK-III) (Pantothenic acid kinase) 274 72.522 Strong candidate 0.4211 ProteomeLM contextual shift 0.09458899 1.0 55 1.0 836 28 0.9089 0.9086 90.86 0.685 1.0 2.7.1.33 PATHWAY: Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 1/5. {ECO:0000255|HAMAP-Rule:MF_01274}. cofactor biosynthesis, enzyme, kinase, cofactor ProteomeLM contextual percentile 0.42; strong pocket/AF2Bind evidence; essential-process annotation; high-confidence Boltz2 model; matched: cofactor biosynthesis, enzyme, kinase, cofactor /main_page_ml/ML0232 2026-05-30T13:09:52Z 264 ML2158 Q9CBD9 ML2158 Uncharacterized protein 130 72.521 Strong candidate 0.9831 ProteomeLM contextual shift 0.8108962 1.0 22 1.0 448 116 0.9875 0.4488 44.88 0.0 0.8625 ProteomeLM contextual percentile 0.98; strong pocket/AF2Bind evidence /main_page_ml/ML2158 2026-05-30T13:09:52Z 265 ML1517 Q9CBW2 ML1517 Uncharacterized protein 93 72.517 Strong candidate 0.9342 ProteomeLM contextual shift 0.50210905 1.0 12 1.0 330 102 0.9836 0.7244 72.44 0.0 0.7575 ProteomeLM contextual percentile 0.93; strong pocket/AF2Bind evidence /main_page_ml/ML1517 2026-05-30T13:09:52Z 266 ML0897 Q7AQD3 ML0897 non-specific serine/threonine protein kinase (EC 2.7.11.1) 400 72.511 Strong candidate 0.6648 ProteomeLM contextual shift 0.12818187 1.0 110 1.0 1260 120 0.9497 0.7043 70.43 0.36 1.0 2.7.11.1 kinase ProteomeLM contextual percentile 0.66; strong pocket/AF2Bind evidence; functional annotation support; matched: kinase /main_page_ml/ML0897 2026-05-30T13:09:52Z 267 ML2587 Q9CD16 yrbE1A ML2587 Conserved membrane protein 267 72.481 Strong candidate 0.8283 ProteomeLM contextual shift 0.18601339 1.0 50 1.0 805 8 0.6886 0.8265 82.65 0.08 0.8625 ProteomeLM contextual percentile 0.83; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML2587 2026-05-30T13:09:52Z 268 ML0397 Q9CCU8 ML0397 Transporter protein 602 72.454 Strong candidate 0.8139 ProteomeLM contextual shift 0.17520766 1.0 90 1.0 1829 6 0.7432 0.7842 78.42 0.125 0.8625 transcription ProteomeLM contextual percentile 0.81; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: transcription /main_page_ml/ML0397 2026-05-30T13:09:52Z 269 ML0796 Q7AQF5 ML0796 Uncharacterized protein 58 72.451 Strong candidate 0.9762 ProteomeLM contextual shift 0.73498183 1.0 8 1.0 190 32 0.8844 0.5709 57.09 0.0 0.7575 ProteomeLM contextual percentile 0.98; strong pocket/AF2Bind evidence /main_page_ml/ML0796 2026-05-30T13:09:52Z 270 ML0760 Q9CCK0 whiB2 whiB ML0760 Transcriptional regulator WhiB 89 72.433 Strong candidate 0.6955 ProteomeLM contextual shift 0.13573195 1.0 22 1.0 315 96 0.953 0.8341 83.41 0.29 0.895 transcription, nad, reductase, cofactor ProteomeLM contextual percentile 0.70; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: transcription, nad, reductase, cofactor /main_page_ml/ML0760 2026-05-30T13:09:52Z 271 ML1508 Q9CBW7 ML1508 Pyridoxamine 5'-phosphate oxidase N-terminal domain-containing protein 163 72.422 Strong candidate 0.7726 ProteomeLM contextual shift 0.15859333 1.0 54 1.0 331 10 0.9316 0.8783 87.83 0.08 1.0 enzyme, oxidoreductase, reductase ProteomeLM contextual percentile 0.77; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: enzyme, oxidoreductase, reductase /main_page_ml/ML1508 2026-05-30T13:09:52Z 272 ML0406 Q49723 ML0406 B1620_C2_214 MLCL383.02 EspC protein homolog 106 72.409 Strong candidate 0.8747 ProteomeLM contextual shift 0.24810097 1.0 10 1.0 378 0 0.4242 0.762 76.2 0.08 0.7575 ProteomeLM contextual percentile 0.87; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML0406 2026-05-30T13:09:52Z 273 ML0009 Q9CDF0 ML0009 Uncharacterized protein 63 72.395 Strong candidate 0.9919 ProteomeLM contextual shift 0.9998865 1.0 14 1.0 194 10 0.5483 0.5105 51.05 0.0 0.7575 ProteomeLM contextual percentile 0.99; strong pocket/AF2Bind evidence /main_page_ml/ML0009 2026-05-30T13:09:52Z 274 ML2478 Q9CB30 ML2478 Uncharacterized protein 129 72.387 Strong candidate 0.9818 ProteomeLM contextual shift 0.79643786 1.0 30 1.0 439 104 0.9825 0.4398 43.98 0.0 0.8625 ProteomeLM contextual percentile 0.98; strong pocket/AF2Bind evidence /main_page_ml/ML2478 2026-05-30T13:09:52Z 275 ML2476 Q9CB31 ML2476 Uncharacterized protein 55 72.385 Strong candidate 0.9768 ProteomeLM contextual shift 0.7370013 1.0 8 1.0 123 26 0.7665 0.5622 56.22 0.0 0.7575 ProteomeLM contextual percentile 0.98; strong pocket/AF2Bind evidence /main_page_ml/ML2476 2026-05-30T13:09:52Z 276 ML2618 Q9CD01 ML2618 Probable integral membrane protein 352 72.337 Strong candidate 0.8528 ProteomeLM contextual shift 0.21127376 1.0 70 1.0 1099 86 0.9068 0.7266 72.66 0.08 0.8625 ProteomeLM contextual percentile 0.85; strong pocket/AF2Bind evidence /main_page_ml/ML2618 2026-05-30T13:09:52Z 277 ML2531 Q9CD33 esxR ML2531 ESAT-6-like protein EsxR 96 72.308 Strong candidate 0.8559 ProteomeLM contextual shift 0.21451248 1.0 14 1.0 293 10 0.6103 0.8177 81.77 0.08 0.7575 ProteomeLM contextual percentile 0.86; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML2531 2026-05-30T13:09:52Z 278 ML0029 Q9CDE0 ML0029 Possible membrane protein 201 72.303 Strong candidate 0.9799 ProteomeLM contextual shift 0.7719387 1.0 40 1.0 649 92 0.9391 0.4379 43.79 0.0 0.8625 ProteomeLM contextual percentile 0.98; strong pocket/AF2Bind evidence /main_page_ml/ML0029 2026-05-30T13:09:52Z 279 ML0203 Q7AQM1 ML0203 Membrane protein 569 72.291 Strong candidate 0.8409 ProteomeLM contextual shift 0.19800675 1.0 109 1.0 1151 26 0.7589 0.9236 92.36 0.0 0.8625 ProteomeLM contextual percentile 0.84; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML0203 2026-05-30T13:09:52Z 280 ML0325 Q9CCW3 ML0325 Uncharacterized protein 87 72.277 Strong candidate 0.9605 ProteomeLM contextual shift 0.6248068 1.0 14 1.0 336 150 0.9681 0.6083 60.83 0.0 0.7575 ProteomeLM contextual percentile 0.96; strong pocket/AF2Bind evidence /main_page_ml/ML0325 2026-05-30T13:09:52Z 281 ML2242 Q7APX2 ML2242 Uncharacterized protein 243 72.265 Strong candidate 0.9117 ProteomeLM contextual shift 0.39007816 1.0 22 1.0 769 40 0.9305 0.6732 67.32 0.0 0.8625 ProteomeLM contextual percentile 0.91; strong pocket/AF2Bind evidence /main_page_ml/ML2242 2026-05-30T13:09:52Z 282 ML0956 Q9CCC8 ML0956 Integral membrane protein 169 72.208 Strong candidate 0.7945 ProteomeLM contextual shift 0.16725202 1.0 38 1.0 567 120 0.969 0.9176 91.76 0.08 0.8625 ProteomeLM contextual percentile 0.79; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML0956 2026-05-30T13:09:52Z 283 ML2678 Q7APS1 ML2678 Transglutaminase-like domain-containing protein 1000 72.194 Strong candidate 0.9417 ProteomeLM contextual shift 0.53226805 1.0 216 1.0 3060 0 0.4193 0.6358 63.58 0.0 0.7875 ProteomeLM contextual percentile 0.94; strong pocket/AF2Bind evidence /main_page_ml/ML2678 2026-05-30T13:09:52Z 284 ML0514 Q9CCS8 mltG ML0514 Endolytic murein transglycosylase (EC 4.2.2.29) (Peptidoglycan lytic transglycosylase) (Peptidoglycan polymerization terminase) 421 72.182 Strong candidate 0.5451 ProteomeLM contextual shift 0.10837236 1.0 30 1.0 1288 10 0.7639 0.8203 82.03 0.495 1.0 4.2.2.29 peptidoglycan, cell wall, mur ProteomeLM contextual percentile 0.55; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model; matched: peptidoglycan, cell wall, mur /main_page_ml/ML0514 2026-05-30T13:09:52Z 285 ML1210 Q9CC69 ML1210 Uncharacterized protein 61 72.177 Strong candidate 0.9668 ProteomeLM contextual shift 0.6562397 1.0 14 1.0 223 80 0.9785 0.5764 57.64 0.0 0.7575 ProteomeLM contextual percentile 0.97; strong pocket/AF2Bind evidence /main_page_ml/ML1210 2026-05-30T13:09:52Z 286 ML0926 Q9CCD7 ML0926 Uncharacterized protein 122 72.158 Strong candidate 0.8872 ProteomeLM contextual shift 0.27744928 1.0 16 1.0 405 78 0.939 0.748 74.8 0.0 0.8625 ProteomeLM contextual percentile 0.89; strong pocket/AF2Bind evidence /main_page_ml/ML0926 2026-05-30T13:09:52Z 287 ML1430 Q9CC06 ML1430 Possible membrane protein 108 72.14 Strong candidate 0.9167 ProteomeLM contextual shift 0.41246983 1.0 18 1.0 405 162 0.9765 0.5882 58.82 0.08 0.7575 ProteomeLM contextual percentile 0.92; strong pocket/AF2Bind evidence /main_page_ml/ML1430 2026-05-30T13:09:52Z 288 ML2595 Q9CD08 ML2595 Possible membrane protein 182 72.113 Strong candidate 0.869 ProteomeLM contextual shift 0.23902413 1.0 22 1.0 373 18 0.8372 0.6471 64.71 0.08 0.8625 ProteomeLM contextual percentile 0.87; strong pocket/AF2Bind evidence /main_page_ml/ML2595 2026-05-30T13:09:52Z 289 ML0482 P40832 ruvA ML0482 B1177_C2_188 Holliday junction branch migration complex subunit RuvA 203 72.106 Strong candidate 0.755 ProteomeLM contextual shift 0.15106331 1.0 92 1.0 641 64 0.9114 0.8056 80.56 0.2 0.8625 ProteomeLM contextual percentile 0.76; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML0482 2026-05-30T13:09:52Z 290 ML0376 Q9CCV4 ML0376 Membrane protein 333 72.1 Strong candidate 0.9229 ProteomeLM contextual shift 0.4503034 1.0 52 1.0 1094 190 0.9971 0.6173 61.73 0.0 0.8625 ProteomeLM contextual percentile 0.92; strong pocket/AF2Bind evidence /main_page_ml/ML0376 2026-05-30T13:09:52Z 291 ML1728 Q9CBQ5 ctaD ML1728 Probable cytochrome c oxidase subunit 1 (EC 7.1.1.9) (Cytochrome aa3 subunit 1) (Cytochrome c oxidase polypeptide I) 574 72.074 Strong candidate 0.4117 ProteomeLM contextual shift 0.093453504 1.0 82 1.0 1750 56 0.8709 0.8966 89.66 0.685 1.0 7.1.1.9 PATHWAY: Energy metabolism; oxidative phosphorylation. respiratory, cofactor ProteomeLM contextual percentile 0.41; strong pocket/AF2Bind evidence; essential-process annotation; high-confidence Boltz2 model; matched: respiratory, cofactor /main_page_ml/ML1728 2026-05-30T13:09:52Z 292 ML0142 Q9CD76 ML0142 Possible membrane protein 82 72.071 Strong candidate 0.9718 ProteomeLM contextual shift 0.68818116 1.0 12 1.0 324 156 0.996 0.5483 54.83 0.0 0.7575 ProteomeLM contextual percentile 0.97; strong pocket/AF2Bind evidence /main_page_ml/ML0142 2026-05-30T13:09:52Z 293 ML0181 Q7AQM9 ML0181 5-formyltetrahydrofolate cyclo-ligase (EC 6.3.3.2) 197 72.05 Strong candidate 0.5006 ProteomeLM contextual shift 0.102824524 1.0 16 1.0 650 118 0.9944 0.9028 90.28 0.525 1.0 6.3.3.2 folate, ligase, cofactor ProteomeLM contextual percentile 0.50; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model; matched: folate, ligase, cofactor /main_page_ml/ML0181 2026-05-30T13:09:52Z 294 ML1794 Q9CBM9 ML1794 Putative cystathionine beta-lyase (CBL) (EC 4.4.1.13) (Beta-cystathionase) (Cysteine lyase) (Cysteine-S-conjugate beta-lyase) 402 72.046 Strong candidate 0.4912 ProteomeLM contextual shift 0.10201998 1.0 86 1.0 1266 120 0.9663 0.9453 94.53 0.52 1.0 4.4.1.13 PATHWAY: Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homocysteine from L-cystathionine: step 1/1. transferase, lyase, cofactor ProteomeLM contextual percentile 0.49; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model; matched: transferase, lyase, cofactor /main_page_ml/ML1794 2026-05-30T13:09:52Z 295 ML1796 P13733 ML1796 Uncharacterized protein ML1796 137 72.017 Strong candidate 0.9555 ProteomeLM contextual shift 0.5957859 1.0 22 1.0 296 44 0.947 0.4949 49.49 0.0 0.8625 ProteomeLM contextual percentile 0.96; strong pocket/AF2Bind evidence /main_page_ml/ML1796 2026-05-30T13:09:52Z 296 ML2196 Q9CBC8 thiX ML2196 Thiredoxin 140 72.017 Strong candidate 0.7976 ProteomeLM contextual shift 0.16879421 1.0 12 1.0 439 38 0.8562 0.75 75.0 0.08 1.0 reductase ProteomeLM contextual percentile 0.80; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: reductase /main_page_ml/ML2196 2026-05-30T13:09:52Z 297 ML1575 Q9CBU8 ML1575 Uncharacterized protein 97 72.008 Strong candidate 0.9825 ProteomeLM contextual shift 0.79731214 1.0 19 1.0 359 136 0.9703 0.5047 50.47 0.0 0.7575 ProteomeLM contextual percentile 0.98; strong pocket/AF2Bind evidence /main_page_ml/ML1575 2026-05-30T13:09:52Z 298 ML1466 Q9CBZ3 rpmA ML1466 Large ribosomal subunit protein bL27 (50S ribosomal protein L27) 88 72.001 Strong candidate 0.7776 ProteomeLM contextual shift 0.16055252 1.0 10 1.0 292 56 0.8704 0.7911 79.11 0.215 0.7575 translation, ribosome, ribosomal ProteomeLM contextual percentile 0.78; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: translation, ribosome, ribosomal /main_page_ml/ML1466 2026-05-30T13:09:52Z 299 ML0958 Q9CCC6 ML0958 Membrane protein 143 71.999 Strong candidate 0.9862 ProteomeLM contextual shift 0.861493 1.0 18 1.0 302 32 0.7937 0.3856 38.56 0.0 0.8625 ProteomeLM contextual percentile 0.99; strong pocket/AF2Bind evidence /main_page_ml/ML0958 2026-05-30T13:09:52Z 300 ML2253 Q7APW9 ML2253 Antigen 84 homolog 71 71.958 Strong candidate 0.9392 ProteomeLM contextual shift 0.52120703 1.0 16 1.0 225 24 0.758 0.6511 65.11 0.0 0.7575 ProteomeLM contextual percentile 0.94; strong pocket/AF2Bind evidence /main_page_ml/ML2253 2026-05-30T13:09:52Z 301 ML0298 Q7AQK0 ML0298 Thiamine biosynthesis protein ThiS 74 71.953 Strong candidate 0.8759 ProteomeLM contextual shift 0.2494621 1.0 8 1.0 264 84 0.9513 0.8721 87.21 0.0 0.7575 ProteomeLM contextual percentile 0.88; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML0298 2026-05-30T13:09:52Z 302 ML0137 Q7AQN7 mmpL7 ML0137 Membrane protein 902 71.951 Strong candidate 0.8246 ProteomeLM contextual shift 0.18329392 1.0 175 1.0 2766 0 0.2709 0.7716 77.16 0.125 0.7875 cell division ProteomeLM contextual percentile 0.82; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: cell division /main_page_ml/ML0137 2026-05-30T13:09:52Z 303 ML2204 Q9CBC3 ML2204 DUF3073 domain-containing protein 62 71.94 Strong candidate 0.9749 ProteomeLM contextual shift 0.7242695 1.0 10 1.0 208 44 0.8874 0.5243 52.43 0.0 0.7575 ProteomeLM contextual percentile 0.97; strong pocket/AF2Bind evidence /main_page_ml/ML2204 2026-05-30T13:09:52Z 304 ML0246 Q9CD47 lpqT ML0246 Putative lipoprotein LpqT 218 71.93 Strong candidate 0.8289 ProteomeLM contextual shift 0.18728122 1.0 35 1.0 463 54 0.9714 0.7692 76.92 0.08 0.8625 ProteomeLM contextual percentile 0.83; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML0246 2026-05-30T13:09:52Z 305 ML1733 Q9CBQ1 ML1733 TetR-family transcriptional regulator 275 71.917 Strong candidate 0.8327 ProteomeLM contextual shift 0.18976559 1.0 54 1.0 918 186 0.9904 0.6647 66.47 0.125 0.8625 transcription ProteomeLM contextual percentile 0.83; strong pocket/AF2Bind evidence; matched: transcription /main_page_ml/ML1733 2026-05-30T13:09:52Z 306 ML0538 Q9CCR0 PE ML0538 PE-family protein 102 71.909 Strong candidate 0.8954 ProteomeLM contextual shift 0.29302692 1.0 8 1.0 327 42 0.7826 0.7997 79.97 0.0 0.7575 ProteomeLM contextual percentile 0.90; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML0538 2026-05-30T13:09:52Z 307 ML1638 Q9CBS9 ML1638 MLCB1243.37 Uncharacterized protein ML1638 232 71.901 Strong candidate 0.8822 ProteomeLM contextual shift 0.26425445 1.0 18 1.0 707 22 0.7234 0.7399 73.99 0.0 0.8625 ProteomeLM contextual percentile 0.88; strong pocket/AF2Bind evidence /main_page_ml/ML1638 2026-05-30T13:09:52Z 308 ML1855 O32989 rpmC ML1855 MLCB2492.10 Large ribosomal subunit protein uL29 (50S ribosomal protein L29) 80 71.9 Strong candidate 0.7675 ProteomeLM contextual shift 0.15688135 1.0 8 1.0 248 10 0.7474 0.8161 81.61 0.215 0.7575 translation, ribosome, ribosomal ProteomeLM contextual percentile 0.77; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: translation, ribosome, ribosomal /main_page_ml/ML1855 2026-05-30T13:09:52Z 309 ML2491 Q9CB25 ML2491 DUF4185 domain-containing protein 333 71.876 Strong candidate 0.8202 ProteomeLM contextual shift 0.18091452 1.0 80 1.0 1031 64 0.9075 0.9545 95.45 0.0 0.8625 ProteomeLM contextual percentile 0.82; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML2491 2026-05-30T13:09:52Z 310 ML1243 Q9CC60 ML1243 Uncharacterized protein 153 71.847 Strong candidate 0.9655 ProteomeLM contextual shift 0.6519698 1.0 28 1.0 537 156 0.9981 0.4428 44.28 0.0 0.8625 ProteomeLM contextual percentile 0.97; strong pocket/AF2Bind evidence /main_page_ml/ML1243 2026-05-30T13:09:52Z 311 ML1053 Q7AQ88 ML1053 ML1183 PE domain-containing protein 99 71.819 Strong candidate 0.8703 ProteomeLM contextual shift 0.2398556 1.0 10 1.0 219 2 0.6444 0.8784 87.84 0.0 0.7575 ProteomeLM contextual percentile 0.87; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML1053 2026-05-30T13:09:52Z 312 ML1045 Q9CCB2 chdC ML1045 Coproheme decarboxylase (EC 1.3.98.5) (Coproheme III oxidative decarboxylase) (Hydrogen peroxide-dependent heme synthase) 231 71.797 Strong candidate 0.4123 ProteomeLM contextual shift 0.09348178 1.0 86 1.0 496 68 0.995 0.9567 95.67 0.64 1.0 1.3.98.5 PATHWAY: Porphyrin-containing compound metabolism; protoheme biosynthesis. {ECO:0000256|HAMAP-Rule:MF_02244}. oxidoreductase, reductase, synthase ProteomeLM contextual percentile 0.41; strong pocket/AF2Bind evidence; essential-process annotation; high-confidence Boltz2 model; matched: oxidoreductase, reductase, synthase /main_page_ml/ML1045 2026-05-30T13:09:52Z 313 ML1701 O33106 pfkA ML1701 MLCB637.14 ATP-dependent 6-phosphofructokinase (ATP-PFK) (Phosphofructokinase) (EC 2.7.1.11) (Phosphohexokinase) 343 71.787 Strong candidate 0.4179 ProteomeLM contextual shift 0.09417768 1.0 98 1.0 719 66 0.9673 0.936 93.6 0.64 1.0 2.7.1.11 PATHWAY: Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 3/4. {ECO:0000255|HAMAP-Rule:MF_01976}. kinase, transferase, cofactor ProteomeLM contextual percentile 0.42; strong pocket/AF2Bind evidence; essential-process annotation; high-confidence Boltz2 model; matched: kinase, transferase, cofactor /main_page_ml/ML1701 2026-05-30T13:09:52Z 314 ML2347 Q7APW0 ML2347 Membrane protein 336 71.781 Strong candidate 0.8697 ProteomeLM contextual shift 0.23970686 1.0 56 1.0 1048 80 0.936 0.7718 77.18 0.0 0.8625 ProteomeLM contextual percentile 0.87; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML2347 2026-05-30T13:09:52Z 315 ML0611 P53530 lepA ML0611 B1937_F3_81 Elongation factor 4 (EF-4) (EC 3.6.5.n1) (Ribosomal back-translocase LepA) 646 71.778 Strong candidate 0.4724 ProteomeLM contextual shift 0.10023043 1.0 107 1.0 1306 28 0.7862 0.7943 79.43 0.615 1.0 3.6.5.n1 translation, ribosome, ribosomal ProteomeLM contextual percentile 0.47; strong pocket/AF2Bind evidence; essential-process annotation; high-confidence Boltz2 model; matched: translation, ribosome, ribosomal /main_page_ml/ML0611 2026-05-30T13:09:52Z 316 ML0291 Q7AQK1 ML0291 Uncharacterized protein 130 71.762 Strong candidate 0.9843 ProteomeLM contextual shift 0.8196001 1.0 14 1.0 424 68 0.9348 0.3686 36.86 0.0 0.8625 ProteomeLM contextual percentile 0.98; strong pocket/AF2Bind evidence /main_page_ml/ML0291 2026-05-30T13:09:52Z 317 ML2244 Q9CBC0 ML2244 Uncharacterized protein 113 71.751 Strong candidate 0.9931 ProteomeLM contextual shift 1.0131991 1.0 14 1.0 387 56 0.9173 0.4417 44.17 0.0 0.7575 ProteomeLM contextual percentile 0.99; strong pocket/AF2Bind evidence /main_page_ml/ML2244 2026-05-30T13:09:52Z 318 ML0676 Q9CCM4 ML0676 DUF732 domain-containing protein 158 71.742 Strong candidate 0.896 ProteomeLM contextual shift 0.29521134 1.0 22 1.0 504 60 0.9225 0.6758 67.58 0.0 0.8625 ProteomeLM contextual percentile 0.90; strong pocket/AF2Bind evidence /main_page_ml/ML0676 2026-05-30T13:09:52Z 319 ML1966 Q7AQ09 lpqH ML1966 Possible lipoprotein 161 71.735 Strong candidate 0.8471 ProteomeLM contextual shift 0.20312978 1.0 38 1.0 529 92 0.9893 0.6861 68.61 0.08 0.8625 ProteomeLM contextual percentile 0.85; strong pocket/AF2Bind evidence /main_page_ml/ML1966 2026-05-30T13:09:52Z 320 ML0525 Q9CCR7 ML0525 Uncharacterized protein 58 71.725 Strong candidate 0.9837 ProteomeLM contextual shift 0.81280375 1.0 10 1.0 218 88 0.9526 0.472 47.2 0.0 0.7575 ProteomeLM contextual percentile 0.98; strong pocket/AF2Bind evidence /main_page_ml/ML0525 2026-05-30T13:09:52Z 321 ML1148 Q7AQ91 ML1148 Doubtful CDS 51 71.713 Strong candidate 0.943 ProteomeLM contextual shift 0.5375771 1.0 12 1.0 211 116 0.9808 0.6134 61.34 0.0 0.7575 ProteomeLM contextual percentile 0.94; strong pocket/AF2Bind evidence /main_page_ml/ML1148 2026-05-30T13:09:52Z 322 ML0369 Q49877 ML0369 Uncharacterized protein 118 71.695 Strong candidate 0.9574 ProteomeLM contextual shift 0.603033 1.0 26 1.0 418 128 0.9828 0.5611 56.11 0.0 0.7575 ProteomeLM contextual percentile 0.96; strong pocket/AF2Bind evidence /main_page_ml/ML0369 2026-05-30T13:09:52Z 323 ML1344 Q9CC35 ML1344 Doubtful CDS 86 71.691 Strong candidate 0.9279 ProteomeLM contextual shift 0.47830352 1.0 18 1.0 343 170 0.9842 0.5038 50.38 0.08 0.7575 ProteomeLM contextual percentile 0.93; strong pocket/AF2Bind evidence /main_page_ml/ML1344 2026-05-30T13:09:52Z 324 ML0950 Q9CCD0 ML0950 Uncharacterized protein 66 71.684 Strong candidate 0.9774 ProteomeLM contextual shift 0.7453177 1.0 8 1.0 255 114 0.9405 0.4898 48.98 0.0 0.7575 ProteomeLM contextual percentile 0.98; strong pocket/AF2Bind evidence /main_page_ml/ML0950 2026-05-30T13:09:52Z 325 ML2615 Q7APT1 ML2615 Probable membrane protein 229 71.669 Strong candidate 0.8108 ProteomeLM contextual shift 0.1742552 1.0 42 1.0 480 44 0.91 0.8067 80.67 0.08 0.8625 ProteomeLM contextual percentile 0.81; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML2615 2026-05-30T13:09:52Z 326 ML0388 Q49721 ML0388 B1620_C2_193 Uncharacterized oxidoreductase ML0388 (EC 1.-.-.-) 375 71.659 Strong candidate 0.641 ProteomeLM contextual shift 0.12321484 1.0 114 1.0 1155 90 0.9249 0.9425 94.25 0.24 1.0 1.-.-.- oxidoreductase, dehydrogenase, reductase ProteomeLM contextual percentile 0.64; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: oxidoreductase, dehydrogenase, reductase /main_page_ml/ML0388 2026-05-30T13:09:52Z 327 ML2113 Q50123 ML2113 Toxin 181 71.642 Strong candidate 0.8609 ProteomeLM contextual shift 0.22205235 1.0 28 1.0 396 68 0.9367 0.7886 78.86 0.0 0.8625 ProteomeLM contextual percentile 0.86; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML2113 2026-05-30T13:09:52Z 328 ML2252 Q7APX0 ML2252 Uncharacterized protein 78 71.635 Strong candidate 0.9737 ProteomeLM contextual shift 0.70350075 1.0 12 1.0 246 24 0.6841 0.4981 49.81 0.0 0.7575 ProteomeLM contextual percentile 0.97; strong pocket/AF2Bind evidence /main_page_ml/ML2252 2026-05-30T13:09:52Z 329 ML2532 Q9CD32 ML2532 PE-family protein 98 71.614 Strong candidate 0.8797 ProteomeLM contextual shift 0.25439942 1.0 8 1.0 236 0 0.3924 0.825 82.5 0.0 0.7575 ProteomeLM contextual percentile 0.88; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML2532 2026-05-30T13:09:52Z 330 ML2268 Q9CBB2 menC ML2268 o-succinylbenzoate synthase (OSB synthase) (OSBS) (EC 4.2.1.113) (4-(2'-carboxyphenyl)-4-oxybutyric acid synthase) (o-succinylbenzoic acid synthase) 334 71.611 Strong candidate 0.3947 ProteomeLM contextual shift 0.09207665 1.0 72 1.0 1050 96 0.8964 0.9096 90.96 0.685 1.0 4.2.1.113 PATHWAY: Quinol/quinone metabolism; 1,4-dihydroxy-2-naphthoate biosynthesis; 1,4-dihydroxy-2-naphthoate from chorismate: step 4/7. {ECO:0000255|HAMAP-Rule:MF_00470}.; PATHWAY: Quinol/quinone metabolism; menaquinone biosynthesis. {ECO:0000255|HAMAP-Rule:MF_00470}. menaquinone, enzyme, synthase, cofactor ProteomeLM contextual percentile 0.39; strong pocket/AF2Bind evidence; essential-process annotation; high-confidence Boltz2 model; matched: menaquinone, enzyme, synthase, cofactor /main_page_ml/ML2268 2026-05-30T13:09:52Z 331 ML0470 Q7AQI7 ML0470 Uncharacterized protein 96 71.608 Strong candidate 0.9981 ProteomeLM contextual shift 1.1323123 1.0 12 1.0 311 46 0.7294 0.4099 40.99 0.0 0.7575 ProteomeLM contextual percentile 1.00; strong pocket/AF2Bind evidence /main_page_ml/ML0470 2026-05-30T13:09:52Z 332 ML2354 Q9CB70 ML2354 Polyketide synthase 1822 71.607 Strong candidate 0.7224 ProteomeLM contextual shift 0.14311387 1.0 297 1.0 0 0 0.0 0.8072 80.72 0.245 0.835 cell wall, synthase ProteomeLM contextual percentile 0.72; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: cell wall, synthase /main_page_ml/ML2354 2026-05-30T13:09:52Z 333 ML0569 Q7AQI6 ML0569 Membrane protein 271 71.59 Strong candidate 0.5627 ProteomeLM contextual shift 0.11092038 1.0 44 1.0 856 86 0.969 0.7897 78.97 0.45 1.0 PATHWAY: Cell wall biogenesis; peptidoglycan biosynthesis. {ECO:0000256|ARBA:ARBA00004752, ECO:0000256|PROSITE-ProRule:PRU01373}. peptidoglycan, cell wall, transferase ProteomeLM contextual percentile 0.56; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model; matched: peptidoglycan, cell wall, transferase /main_page_ml/ML0569 2026-05-30T13:09:52Z 334 ML2356 Q7APV9 ML2356 Polyketide synthase 1540 71.587 Strong candidate 0.8089 ProteomeLM contextual shift 0.17262587 1.0 226 1.0 0 0 0.0 0.8325 83.25 0.08 0.835 synthase ProteomeLM contextual percentile 0.81; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: synthase /main_page_ml/ML2356 2026-05-30T13:09:52Z 335 ML1998 P53525 ML1998 o659 Uncharacterized protein ML1998 659 71.567 Strong candidate 0.7863 ProteomeLM contextual shift 0.1635872 1.0 148 1.0 1997 40 0.8113 0.882 88.2 0.08 0.8625 ProteomeLM contextual percentile 0.79; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML1998 2026-05-30T13:09:52Z 336 ML2121 Q7APY9 ML2121 Uncharacterized protein 136 71.563 Strong candidate 0.9135 ProteomeLM contextual shift 0.39298335 1.0 14 1.0 477 138 0.9841 0.5964 59.64 0.0 0.8625 ProteomeLM contextual percentile 0.91; strong pocket/AF2Bind evidence /main_page_ml/ML2121 2026-05-30T13:09:52Z 337 ML1166 P53424 aosR ML1166 B1549_C3_236 Putative oxidative stress regulator AosR 217 71.539 Strong candidate 0.8302 ProteomeLM contextual shift 0.1880801 1.0 18 1.0 395 10 0.7412 0.8857 88.57 0.0 0.8625 ProteomeLM contextual percentile 0.83; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML1166 2026-05-30T13:09:52Z 338 ML1229 Q49624 pks3 ML1229 Mycocerosic acid synthase (Polyketide synthase) 2118 71.537 Strong candidate 0.7162 ProteomeLM contextual shift 0.14105256 1.0 203 1.0 0 0 0.0 0.8222 82.22 0.245 0.835 cell wall, oxidoreductase, reductase, synthase ProteomeLM contextual percentile 0.72; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: cell wall, oxidoreductase, reductase, synthase /main_page_ml/ML1229 2026-05-30T13:09:52Z 339 ML0963 Q9CCC4 ML0963 Uncharacterized protein 154 71.519 Strong candidate 0.9994 ProteomeLM contextual shift 1.2537651 1.0 18 1.0 520 116 0.9647 0.2916 29.16 0.0 0.8625 ProteomeLM contextual percentile 1.00; strong pocket/AF2Bind evidence /main_page_ml/ML0963 2026-05-30T13:09:52Z 340 ML1763 Q9CBN9 ML1763 Uncharacterized protein 71 71.519 Strong candidate 0.99 ProteomeLM contextual shift 0.9227457 1.0 8 1.0 271 116 0.9672 0.4295 42.95 0.0 0.7575 ProteomeLM contextual percentile 0.99; strong pocket/AF2Bind evidence /main_page_ml/ML1763 2026-05-30T13:09:52Z 341 ML1604 Q9CBT7 ML1604 Uncharacterized protein 129 71.51 Strong candidate 0.9731 ProteomeLM contextual shift 0.7021279 1.0 12 1.0 442 110 0.9124 0.3828 38.28 0.0 0.8625 ProteomeLM contextual percentile 0.97; strong pocket/AF2Bind evidence /main_page_ml/ML1604 2026-05-30T13:09:52Z 342 ML0008 Q9CDF1 ML0008 Uncharacterized protein 124 71.509 Strong candidate 0.9906 ProteomeLM contextual shift 0.9365551 1.0 14 1.0 420 96 0.9949 0.3213 32.13 0.0 0.8625 ProteomeLM contextual percentile 0.99; strong pocket/AF2Bind evidence /main_page_ml/ML0008 2026-05-30T13:09:52Z 343 ML1347 Q9CC33 ML1347 UPF0434 protein ML1347 77 71.508 Strong candidate 0.8766 ProteomeLM contextual shift 0.25075784 1.0 8 1.0 250 38 0.804 0.8253 82.53 0.0 0.7575 ProteomeLM contextual percentile 0.88; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML1347 2026-05-30T13:09:52Z 344 ML0778 Q9CCI7 hpf ML0778 Ribosome hibernation promoting factor (HPF) 229 71.493 Strong candidate 0.7907 ProteomeLM contextual shift 0.1656083 1.0 26 1.0 483 50 0.953 0.5893 58.93 0.215 0.8625 translation, ribosome, ribosomal ProteomeLM contextual percentile 0.79; strong pocket/AF2Bind evidence; matched: translation, ribosome, ribosomal /main_page_ml/ML0778 2026-05-30T13:09:52Z 345 ML2022 Q9CBF9 ML2022 Uncharacterized protein 174 71.485 Strong candidate 0.9662 ProteomeLM contextual shift 0.6558752 1.0 16 1.0 585 86 0.9222 0.4044 40.44 0.0 0.8625 ProteomeLM contextual percentile 0.97; strong pocket/AF2Bind evidence /main_page_ml/ML2022 2026-05-30T13:09:52Z 346 ML2537 Q9CD28 eccA3 ML2537 ESX-3 secretion system protein EccA3 (ESX conserved component A3) (Type VII secretion system protein EccA3) (T7SS protein EccA3) 640 71.478 Strong candidate 0.7406 ProteomeLM contextual shift 0.14688468 1.0 58 1.0 1945 10 0.7589 0.7932 79.32 0.2 0.8625 ProteomeLM contextual percentile 0.74; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML2537 2026-05-30T13:09:52Z 347 ML1494 Q9CBX5 ML1494 Conserved membrane protein 117 71.471 Strong candidate 0.8835 ProteomeLM contextual shift 0.26568457 1.0 16 1.0 280 92 0.9817 0.7975 79.75 0.0 0.7575 ProteomeLM contextual percentile 0.88; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML1494 2026-05-30T13:09:52Z 348 ML0837 Q9CCG0 ML0837 Class II aldolase/adducin N-terminal domain-containing protein 127 71.471 Strong candidate 0.8578 ProteomeLM contextual shift 0.21616286 1.0 20 1.0 467 172 0.9982 0.7824 78.24 0.0 0.8625 ProteomeLM contextual percentile 0.86; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML0837 2026-05-30T13:09:52Z 349 ML0448 Q7AQJ2 ML0448 Uncharacterized protein 90 71.453 Strong candidate 0.9975 ProteomeLM contextual shift 1.111586 1.0 18 1.0 286 32 0.7533 0.3965 39.65 0.0 0.7575 ProteomeLM contextual percentile 1.00; strong pocket/AF2Bind evidence /main_page_ml/ML0448 2026-05-30T13:09:52Z 350 ML0097 Q05861 fbpA ML0097 Diacylglycerol acyltransferase/mycolyltransferase Ag85A (DGAT) (EC 2.3.1.122) (EC 2.3.1.20) (Acyl-CoA:diacylglycerol acyltransferase) (Antigen 85 complex A) (85A) (Ag85A) (Fibronectin-binding protein A) (Fbps A) 330 71.451 Strong candidate 0.4969 ProteomeLM contextual shift 0.10257252 1.0 70 1.0 1028 76 0.9855 0.8561 85.61 0.525 1.0 2.3.1.122; 2.3.1.20 cell wall, transferase ProteomeLM contextual percentile 0.50; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model; matched: cell wall, transferase /main_page_ml/ML0097 2026-05-30T13:09:52Z 351 ML2659 Q9CCY9 ML2659 Probable secreted serine protease 354 71.438 Strong candidate 0.7644 ProteomeLM contextual shift 0.15572973 1.0 34 1.0 1088 52 0.9385 0.8084 80.84 0.08 1.0 protease ProteomeLM contextual percentile 0.76; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: protease /main_page_ml/ML2659 2026-05-30T13:09:52Z 352 ML2357 Q7APV8 ML2357 Polyketide synthase 1871 71.423 Strong candidate 0.792 ProteomeLM contextual shift 0.16584405 1.0 295 1.0 0 0 0.0 0.7854 78.54 0.125 0.835 cell wall, synthase ProteomeLM contextual percentile 0.79; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: cell wall, synthase /main_page_ml/ML2357 2026-05-30T13:09:52Z 353 ML0472 Q9CCT7 ML0472 Uncharacterized protein 80 71.405 Strong candidate 0.9674 ProteomeLM contextual shift 0.6567617 1.0 14 1.0 294 108 0.9842 0.497 49.7 0.0 0.7575 ProteomeLM contextual percentile 0.97; strong pocket/AF2Bind evidence /main_page_ml/ML0472 2026-05-30T13:09:52Z 354 ML0069 Q9CDC9 ML0069 HTH cro/C1-type domain-containing protein 132 71.404 Strong candidate 0.7838 ProteomeLM contextual shift 0.16276889 1.0 15 1.0 430 68 0.9034 0.8745 87.45 0.08 0.8625 ProteomeLM contextual percentile 0.78; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML0069 2026-05-30T13:09:52Z 355 ML0638 Q49769 ML0638 B1937_F3_110 Uncharacterized protein ML0638 100 71.401 Strong candidate 0.953 ProteomeLM contextual shift 0.5848191 1.0 8 1.0 342 84 0.9721 0.3871 38.71 0.08 0.7575 ProteomeLM contextual percentile 0.95; strong pocket/AF2Bind evidence /main_page_ml/ML0638 2026-05-30T13:09:52Z 356 ML0824 Q9CCG6 furB ML0824 Zinc uptake regulation protein 131 71.397 Strong candidate 0.6729 ProteomeLM contextual shift 0.1298227 1.0 43 1.0 435 84 0.9019 0.7944 79.44 0.245 1.0 transcription, cofactor ProteomeLM contextual percentile 0.67; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: transcription, cofactor /main_page_ml/ML0824 2026-05-30T13:09:52Z 357 ML1011 Q9CCB6 ML1011 Uncharacterized protein 140 71.378 Strong candidate 0.9944 ProteomeLM contextual shift 1.0256461 1.0 14 1.0 454 68 0.9392 0.2951 29.51 0.0 0.8625 ProteomeLM contextual percentile 0.99; strong pocket/AF2Bind evidence /main_page_ml/ML1011 2026-05-30T13:09:52Z 358 ML1714 Q9CBR4 ML1714 1,4-alpha-glucan branching enzyme (EC 2.4.1.18) (1,4-alpha-D-glucan:1,4-alpha-D-glucan 6-glucosyl-transferase) (Alpha-(1->4)-glucan branching enzyme) (Branching enzyme) 522 71.348 Strong candidate 0.4956 ProteomeLM contextual shift 0.10245128 1.0 90 1.0 1616 100 0.9206 0.9401 94.01 0.48 1.0 2.4.1.18 enzyme, transferase, hydrolase ProteomeLM contextual percentile 0.50; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model; matched: enzyme, transferase, hydrolase /main_page_ml/ML1714 2026-05-30T13:09:52Z 359 ML0656 Q7AQH1 ML0656 Uncharacterized protein 93 71.336 Strong candidate 0.9925 ProteomeLM contextual shift 1.0053227 1.0 10 1.0 311 24 0.7265 0.4024 40.24 0.0 0.7575 ProteomeLM contextual percentile 0.99; strong pocket/AF2Bind evidence /main_page_ml/ML0656 2026-05-30T13:09:52Z 360 ML1811 Q9CBL6 ML1811 Exported p60 protein homologue 241 71.313 Strong candidate 0.8227 ProteomeLM contextual shift 0.18225937 1.0 40 1.0 510 56 0.9632 0.7294 72.94 0.08 0.8625 ProteomeLM contextual percentile 0.82; strong pocket/AF2Bind evidence /main_page_ml/ML1811 2026-05-30T13:09:52Z 361 ML0793 Q9CCI2 ML0793 Abasic site processing protein (EC 3.4.-.-) 252 71.295 Strong candidate 0.6447 ProteomeLM contextual shift 0.12423078 1.0 36 1.0 797 2 0.5537 0.8929 89.29 0.24 1.0 3.4.-.- lyase ProteomeLM contextual percentile 0.64; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: lyase /main_page_ml/ML0793 2026-05-30T13:09:52Z 362 ML0905 O69561 mraZ ML0905 MLCB268.11c Transcriptional regulator MraZ 143 71.293 Strong candidate 0.7563 ProteomeLM contextual shift 0.15197912 1.0 61 1.0 472 86 0.9709 0.8699 86.99 0.125 0.8625 transcription ProteomeLM contextual percentile 0.76; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: transcription /main_page_ml/ML0905 2026-05-30T13:09:52Z 363 ML0233 P46861 lysS ML0233 Lysine--tRNA ligase (EC 6.1.1.6) (Lysyl-tRNA synthetase) (LysRS) 507 71.269 Strong candidate 0.4561 ProteomeLM contextual shift 0.09824376 1.0 131 1.0 1538 34 0.824 0.8904 89.04 0.57 1.0 6.1.1.6 aminoacyl-trna, trna ligase, ligase, synthetase, cofactor ProteomeLM contextual percentile 0.46; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model; matched: aminoacyl-trna, trna ligase, ligase, synthetase, cofactor /main_page_ml/ML0233 2026-05-30T13:09:52Z 364 ML0135 Q9CD81 ML0135 Polyketide synthase 2103 71.263 Strong candidate 0.6216 ProteomeLM contextual shift 0.12056712 1.0 191 1.0 0 0 0.0 0.8059 80.59 0.405 0.835 PATHWAY: Antibiotic biosynthesis. {ECO:0000256|ARBA:ARBA00004792}.; PATHWAY: Lipid metabolism. {ECO:0000256|ARBA:ARBA00005189}. lipid metabolism, oxidoreductase, reductase, synthase ProteomeLM contextual percentile 0.62; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model; matched: lipid metabolism, oxidoreductase, reductase, synthase /main_page_ml/ML0135 2026-05-30T13:09:52Z 365 ML0928 Q9CCD5 ML0928 Uncharacterized protein 94 71.249 Strong candidate 0.9956 ProteomeLM contextual shift 1.0361727 1.0 12 1.0 333 102 0.9507 0.3828 38.28 0.0 0.7575 ProteomeLM contextual percentile 1.00; strong pocket/AF2Bind evidence /main_page_ml/ML0928 2026-05-30T13:09:52Z 366 ML1331 P54079 tatA ML1331 B2126_C1_182 MLCB2533.27 u2126b Sec-independent protein translocase protein TatA 88 71.249 Strong candidate 0.9054 ProteomeLM contextual shift 0.36069283 1.0 10 1.0 322 34 0.7466 0.5385 53.85 0.08 0.7575 ProteomeLM contextual percentile 0.91; strong pocket/AF2Bind evidence /main_page_ml/ML1331 2026-05-30T13:09:52Z 367 ML2044 Q9CBF4 ML2044 Uncharacterized protein 73 71.218 Strong candidate 0.9806 ProteomeLM contextual shift 0.7724119 1.0 10 1.0 170 8 0.6059 0.4323 43.23 0.0 0.7575 ProteomeLM contextual percentile 0.98; strong pocket/AF2Bind evidence /main_page_ml/ML2044 2026-05-30T13:09:52Z 368 ML1982 Q9CBH2 ML1982 Integral membrane protein 102 71.214 Strong candidate 0.9756 ProteomeLM contextual shift 0.7254763 1.0 12 1.0 346 80 0.9425 0.4494 44.94 0.0 0.7575 ProteomeLM contextual percentile 0.98; strong pocket/AF2Bind evidence /main_page_ml/ML1982 2026-05-30T13:09:52Z 369 ML0381 P37578 groEL1 groE1 groL1 ML0381 B1620_C3_228 B229_C3_248 Chaperonin GroEL 1 (EC 5.6.1.7) (60 kDa chaperonin 1) (Chaperonin-60 1) (Cpn60 1) 537 71.174 Strong candidate 0.5188 ProteomeLM contextual shift 0.10464406 1.0 93 1.0 1671 0 0.4429 0.8416 84.16 0.48 1.0 5.6.1.7 isomerase ProteomeLM contextual percentile 0.52; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model; matched: isomerase /main_page_ml/ML0381 2026-05-30T13:09:52Z 370 ML0726 P46392 bccA ML0726 B1308_C1_129 Biotin-dependent acyl-coenzyme A carboxylase alpha3 subunit [Includes: Biotin carboxylase (BC) (EC 6.3.4.14); Biotin carboxyl carrier protein (BCCP)] 598 71.174 Strong candidate 0.3484 ProteomeLM contextual shift 0.085701175 1.0 102 1.0 1827 66 0.8996 0.8481 84.81 0.775 1.0 6.3.4.14 PATHWAY: Lipid metabolism; fatty acid biosynthesis. {ECO:0000250|UniProtKB:P96890}.; PATHWAY: Lipid metabolism; mycolic acid biosynthesis. {ECO:0000250|UniProtKB:P96890}. mycolic, lipid metabolism, fatty acid biosynthesis, enzyme, cofactor ProteomeLM contextual percentile 0.35; strong pocket/AF2Bind evidence; essential-process annotation; high-confidence Boltz2 model; matched: mycolic, lipid metabolism, fatty acid biosynthesis, enzyme, cofactor /main_page_ml/ML0726 2026-05-30T13:09:52Z 371 ML2035 Q9CBF6 ML2035 Uncharacterized protein 87 71.159 Strong candidate 0.995 ProteomeLM contextual shift 1.0351884 1.0 12 1.0 310 98 0.9747 0.3759 37.59 0.0 0.7575 ProteomeLM contextual percentile 0.99; strong pocket/AF2Bind evidence /main_page_ml/ML2035 2026-05-30T13:09:52Z 372 ML1972 Q9CBH6 ML1972 Uncharacterized protein 76 71.158 Strong candidate 0.9223 ProteomeLM contextual shift 0.44669795 1.0 16 1.0 305 154 0.9911 0.6303 63.03 0.0 0.7575 ProteomeLM contextual percentile 0.92; strong pocket/AF2Bind evidence /main_page_ml/ML1972 2026-05-30T13:09:52Z 373 ML1637 Q7AQ37 ML1637 RNase H type-1 domain-containing protein 371 71.157 Strong candidate 0.7249 ProteomeLM contextual shift 0.14364937 1.0 36 1.0 1142 58 0.9241 0.8159 81.59 0.2 0.8625 ProteomeLM contextual percentile 0.72; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML1637 2026-05-30T13:09:52Z 374 ML2230 Q9CBC1 purB ML2230 Adenylosuccinate lyase (ASL) (EC 4.3.2.2) (Adenylosuccinase) 472 71.154 Strong candidate 0.4712 ProteomeLM contextual shift 0.100019984 1.0 208 1.0 984 0 0.3404 0.9263 92.63 0.52 1.0 4.3.2.2 PATHWAY: Purine metabolism; AMP biosynthesis via de novo pathway; AMP from IMP: step 2/2. {ECO:0000256|RuleBase:RU361172}.; PATHWAY: Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate: step 2/2. {ECO:0000256|RuleBase:RU361172}. lyase ProteomeLM contextual percentile 0.47; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model; matched: lyase /main_page_ml/ML2230 2026-05-30T13:09:52Z 375 ML1842 O33000 rpsE ML1842 MLCB2492.21 Small ribosomal subunit protein uS5 (30S ribosomal protein S5) 217 71.151 Strong candidate 0.7519 ProteomeLM contextual shift 0.15000619 1.0 18 1.0 692 82 0.9548 0.691 69.1 0.215 0.8625 translation, ribosome, ribosomal ProteomeLM contextual percentile 0.75; strong pocket/AF2Bind evidence; matched: translation, ribosome, ribosomal /main_page_ml/ML1842 2026-05-30T13:09:52Z 376 ML0939 Q9CCD3 ML0939 Uncharacterized protein 80 71.14 Strong candidate 1.0 ProteomeLM contextual shift 1.2554561 1.0 12 1.0 183 46 0.8905 0.3565 35.65 0.0 0.7575 ProteomeLM contextual percentile 1.00; strong pocket/AF2Bind evidence /main_page_ml/ML0939 2026-05-30T13:09:52Z 377 ML0183 Q7AQM7 moeA ML0183 Molybdopterin molybdenumtransferase (EC 2.10.1.1) 424 71.108 Strong candidate 0.4668 ProteomeLM contextual shift 0.099628836 1.0 58 1.0 854 12 0.6792 0.847 84.7 0.565 1.0 2.10.1.1 PATHWAY: Cofactor biosynthesis; molybdopterin biosynthesis. {ECO:0000256|ARBA:ARBA00005046, ECO:0000256|RuleBase:RU365090}. cofactor biosynthesis, transferase, cofactor ProteomeLM contextual percentile 0.47; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model; matched: cofactor biosynthesis, transferase, cofactor /main_page_ml/ML0183 2026-05-30T13:09:52Z 378 ML1001 Q9CCB9 ML1001 Uncharacterized protein 91 71.101 Strong candidate 0.9969 ProteomeLM contextual shift 1.0775713 1.0 16 1.0 303 60 0.8971 0.3636 36.36 0.0 0.7575 ProteomeLM contextual percentile 1.00; strong pocket/AF2Bind evidence /main_page_ml/ML1001 2026-05-30T13:09:52Z 379 ML2300 Q9CB93 ML2300 Membrane protein 215 71.098 Strong candidate 0.7362 ProteomeLM contextual shift 0.14598757 1.0 8 1.0 653 16 0.7786 0.8731 87.31 0.08 1.0 oxidoreductase, reductase ProteomeLM contextual percentile 0.74; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: oxidoreductase, reductase /main_page_ml/ML2300 2026-05-30T13:09:52Z 380 ML0023 Q9CDE3 ML0023 Uncharacterized protein 103 71.076 Strong candidate 0.9204 ProteomeLM contextual shift 0.42301065 1.0 20 1.0 325 32 0.9006 0.6286 62.86 0.0 0.7575 ProteomeLM contextual percentile 0.92; strong pocket/AF2Bind evidence /main_page_ml/ML0023 2026-05-30T13:09:52Z 381 ML2621 Q9CD00 ML2621 NYN domain-containing protein 195 71.045 Strong candidate 0.8521 ProteomeLM contextual shift 0.2106267 1.0 40 1.0 627 84 0.9107 0.7596 75.96 0.0 0.8625 ProteomeLM contextual percentile 0.85; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML2621 2026-05-30T13:09:52Z 382 ML1078 Q7AQ93 htrA ML1078 Possinble serine protease 533 71.04 Strong candidate 0.802 ProteomeLM contextual shift 0.17023408 1.0 63 1.0 1608 18 0.8165 0.637 63.7 0.08 1.0 protease ProteomeLM contextual percentile 0.80; strong pocket/AF2Bind evidence; matched: protease /main_page_ml/ML1078 2026-05-30T13:09:52Z 383 ML1351 O05678 ML1351 MLC1351.17c Putative 3-methyladenine DNA glycosylase (EC 3.2.2.-) 214 71.036 Strong candidate 0.6316 ProteomeLM contextual shift 0.121947564 1.0 30 1.0 459 62 0.9304 0.9131 91.31 0.24 1.0 3.2.2.- ProteomeLM contextual percentile 0.63; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML1351 2026-05-30T13:09:52Z 384 ML0574 Q7AQI4 ML0574 Uncharacterized protein 105 71.002 Strong candidate 0.9962 ProteomeLM contextual shift 1.0417751 1.0 14 1.0 363 96 0.9512 0.3559 35.59 0.0 0.7575 ProteomeLM contextual percentile 1.00; strong pocket/AF2Bind evidence /main_page_ml/ML0574 2026-05-30T13:09:52Z 385 ML1602 Q9CBT9 ML1602 Uncharacterized protein 106 70.998 Strong candidate 0.9367 ProteomeLM contextual shift 0.5121666 1.0 30 1.0 273 122 0.9845 0.5638 56.38 0.0 0.7575 ProteomeLM contextual percentile 0.94; strong pocket/AF2Bind evidence /main_page_ml/ML1602 2026-05-30T13:09:52Z 386 ML0121 Q9CD93 ML0121 GXWXG domain-containing protein 89 70.994 Strong candidate 0.9868 ProteomeLM contextual shift 0.86245656 1.0 20 1.0 335 136 0.9782 0.388 38.8 0.0 0.7575 ProteomeLM contextual percentile 0.99; strong pocket/AF2Bind evidence /main_page_ml/ML0121 2026-05-30T13:09:52Z 387 ML1989 Q9CBG7 ML1989 Uncharacterized protein 116 70.989 Strong candidate 0.9624 ProteomeLM contextual shift 0.64093226 1.0 16 1.0 408 120 0.9707 0.473 47.3 0.0 0.7575 ProteomeLM contextual percentile 0.96; strong pocket/AF2Bind evidence /main_page_ml/ML1989 2026-05-30T13:09:52Z 388 ML1795 P12809 hsp18 ML1795 18 kDa antigen (HSP 16.7) 148 70.974 Strong candidate 0.849 ProteomeLM contextual shift 0.206112 1.0 208 1.0 504 0 0.4549 0.7634 76.34 0.0 0.8625 ProteomeLM contextual percentile 0.85; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML1795 2026-05-30T13:09:52Z 389 ML2320 Q9CB80 ML2320 PknH-like extracellular domain-containing protein 215 70.966 Strong candidate 0.8133 ProteomeLM contextual shift 0.17498462 1.0 197 1.0 680 70 0.9648 0.8876 88.76 0.0 0.8625 ProteomeLM contextual percentile 0.81; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML2320 2026-05-30T13:09:52Z 390 ML0953 Q9CCC9 ML0953 Uncharacterized protein 79 70.958 Strong candidate 0.9179 ProteomeLM contextual shift 0.41622573 1.0 10 1.0 265 56 0.8934 0.6256 62.56 0.0 0.7575 ProteomeLM contextual percentile 0.92; strong pocket/AF2Bind evidence /main_page_ml/ML0953 2026-05-30T13:09:52Z 391 ML0927 Q9CCD6 ML0927 Uncharacterized protein 102 70.935 Strong candidate 0.9699 ProteomeLM contextual shift 0.66669184 1.0 12 1.0 376 140 0.9739 0.4413 44.13 0.0 0.7575 ProteomeLM contextual percentile 0.97; strong pocket/AF2Bind evidence /main_page_ml/ML0927 2026-05-30T13:09:52Z 392 ML0386 Q49742 ML0386 B1620_F3_131 Uncharacterized protein ML0386 137 70.927 Strong candidate 0.8716 ProteomeLM contextual shift 0.2433712 1.0 25 1.0 444 66 0.9474 0.6797 67.97 0.0 0.8625 ProteomeLM contextual percentile 0.87; strong pocket/AF2Bind evidence /main_page_ml/ML0386 2026-05-30T13:09:52Z 393 ML0078 Q9CDC4 pheA ML0078 Prephenate dehydratase (PDT) (EC 4.2.1.51) 322 70.906 Strong candidate 0.4925 ProteomeLM contextual shift 0.10211071 1.0 70 1.0 977 22 0.8213 0.827 82.7 0.52 1.0 4.2.1.51 PATHWAY: Amino-acid biosynthesis; L-phenylalanine biosynthesis; phenylpyruvate from prephenate: step 1/1. ProteomeLM contextual percentile 0.49; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model /main_page_ml/ML0078 2026-05-30T13:09:52Z 394 ML0527 Q9CCR6 ML0527 Uncharacterized protein 84 70.903 Strong candidate 0.9693 ProteomeLM contextual shift 0.66426986 1.0 8 1.0 300 96 0.9937 0.4403 44.03 0.0 0.7575 ProteomeLM contextual percentile 0.97; strong pocket/AF2Bind evidence /main_page_ml/ML0527 2026-05-30T13:09:52Z 395 ML2278 Q9CBA4 htpX ML2278 Protease HtpX homolog (EC 3.4.24.-) 287 70.877 Strong candidate 0.5952 ProteomeLM contextual shift 0.116572104 1.0 82 1.0 866 10 0.7558 0.7844 78.44 0.36 1.0 3.4.24.- protease, cofactor ProteomeLM contextual percentile 0.60; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model; matched: protease, cofactor /main_page_ml/ML2278 2026-05-30T13:09:52Z 396 ML1151 P52982 ogt ML1151 Methylated-DNA--protein-cysteine methyltransferase (EC 2.1.1.63) (6-O-methylguanine-DNA methyltransferase) (MGMT) (O-6-methylguanine-DNA-alkyltransferase) 165 70.861 Strong candidate 0.495 ProteomeLM contextual shift 0.10240715 1.0 46 1.0 333 6 0.6463 0.8936 89.36 0.48 1.0 2.1.1.63 transferase ProteomeLM contextual percentile 0.49; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model; matched: transferase /main_page_ml/ML1151 2026-05-30T13:09:52Z 397 ML0175 Q9Z5G7 mprB ML0175 MLCB373.27 Signal transduction histidine-protein kinase/phosphatase MprB (EC 2.7.13.3) (EC 3.1.3.-) (Mycobacterial persistence regulator B) 519 70.845 Strong candidate 0.6222 ProteomeLM contextual shift 0.12057958 1.0 42 1.0 1580 6 0.5422 0.6868 68.68 0.36 1.0 2.7.13.3; 3.1.3.- kinase, cofactor ProteomeLM contextual percentile 0.62; strong pocket/AF2Bind evidence; functional annotation support; matched: kinase, cofactor /main_page_ml/ML0175 2026-05-30T13:09:52Z 398 ML0485 P40829 gabT ML0485 B1177_F2_67 MLCB1259.03c 4-aminobutyrate aminotransferase (EC 2.6.1.19) ((S)-3-amino-2-methylpropionate transaminase) (EC 2.6.1.22) (GABA aminotransferase) (GABA-AT) (Gamma-amino-N-butyrate transaminase) (GABA transaminase) (Glutamate:succinic semialdehyde transaminase) (L-AIBAT) 446 70.834 Strong candidate 0.4492 ProteomeLM contextual shift 0.097457565 1.0 87 1.0 1404 132 0.9785 0.9711 97.11 0.52 1.0 2.6.1.19; 2.6.1.22 PATHWAY: Amino-acid degradation; 4-aminobutanoate degradation. transferase, cofactor ProteomeLM contextual percentile 0.45; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model; matched: transferase, cofactor /main_page_ml/ML0485 2026-05-30T13:09:52Z 399 ML0064 Q9CDD3 ML0064 Transcriptional regulator 214 70.831 Strong candidate 0.7412 ProteomeLM contextual shift 0.14691186 1.0 28 1.0 456 56 0.9698 0.8763 87.63 0.125 0.8625 transcription ProteomeLM contextual percentile 0.74; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: transcription /main_page_ml/ML0064 2026-05-30T13:09:52Z 400 ML1182 Q7AQ89 ML1182 PPE-family protein 421 70.825 Strong candidate 0.8803 ProteomeLM contextual shift 0.255001 1.0 50 1.0 1298 30 0.7887 0.4788 47.88 0.08 0.8625 ProteomeLM contextual percentile 0.88; strong pocket/AF2Bind evidence /main_page_ml/ML1182 2026-05-30T13:09:52Z 401 ML1213 Q9CC68 ML1213 Conserved membrane protein 733 70.821 Strong candidate 0.7356 ProteomeLM contextual shift 0.14589418 1.0 122 1.0 2241 4 0.5614 0.8475 84.75 0.08 1.0 transferase ProteomeLM contextual percentile 0.74; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: transferase /main_page_ml/ML1213 2026-05-30T13:09:52Z 402 ML0614 Q49760 ML0614 B1937_F2_47 Uncharacterized protein ML0614 95 70.82 Strong candidate 0.8847 ProteomeLM contextual shift 0.26948118 1.0 12 1.0 308 46 0.8603 0.568 56.8 0.08 0.7575 ProteomeLM contextual percentile 0.88; strong pocket/AF2Bind evidence /main_page_ml/ML0614 2026-05-30T13:09:52Z 403 ML1157 Q7AQ90 ML1157 VOC domain-containing protein 155 70.806 Strong candidate 0.7619 ProteomeLM contextual shift 0.15416627 1.0 48 1.0 530 130 0.9803 0.8915 89.15 0.08 0.8625 ProteomeLM contextual percentile 0.76; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML1157 2026-05-30T13:09:52Z 404 ML2413 Q7APU9 ML2413 Possible phosphoglycerate mutase 202 70.804 Strong candidate 0.7701 ProteomeLM contextual shift 0.15784854 1.0 34 1.0 670 128 0.9938 0.8627 86.27 0.08 0.8625 ProteomeLM contextual percentile 0.77; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML2413 2026-05-30T13:09:52Z 405 ML1172 P46705 murI ML1172 B1549_C2_210 Glutamate racemase (EC 5.1.1.3) 272 70.804 Strong candidate 0.3283 ProteomeLM contextual shift 0.08217162 1.0 40 1.0 839 46 0.9539 0.8813 88.13 0.775 1.0 5.1.1.3 PATHWAY: Cell wall biogenesis; peptidoglycan biosynthesis. {ECO:0000255|HAMAP-Rule:MF_00258}. peptidoglycan, cell wall, mur ProteomeLM contextual percentile 0.33; strong pocket/AF2Bind evidence; essential-process annotation; high-confidence Boltz2 model; matched: peptidoglycan, cell wall, mur /main_page_ml/ML1172 2026-05-30T13:09:52Z 406 ML0686 Q49901 trpS ML0686 L308_C1_147 Tryptophan--tRNA ligase (EC 6.1.1.2) (Tryptophanyl-tRNA synthetase) (TrpRS) 343 70.795 Strong candidate 0.4373 ProteomeLM contextual shift 0.09640763 1.0 95 1.0 1060 62 0.9524 0.9088 90.88 0.57 1.0 6.1.1.2 aminoacyl-trna, trna ligase, ligase, synthetase ProteomeLM contextual percentile 0.44; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model; matched: aminoacyl-trna, trna ligase, ligase, synthetase /main_page_ml/ML0686 2026-05-30T13:09:52Z 407 ML1425 Q7AQ53 ML1425 Probable ABC-transport protein, inner membrane component 283 70.772 Strong candidate 0.8051 ProteomeLM contextual shift 0.17123207 1.0 56 1.0 874 50 0.876 0.7367 73.67 0.08 0.8625 ProteomeLM contextual percentile 0.81; strong pocket/AF2Bind evidence /main_page_ml/ML1425 2026-05-30T13:09:52Z 408 ML0411 Q07297 sra ML0411 MLCL383.14 Serine-rich antigen (25L) (45 kDa protein) 408 70.767 Strong candidate 0.8659 ProteomeLM contextual shift 0.23172756 1.0 58 1.0 1278 68 0.8979 0.5235 52.35 0.08 0.8625 ProteomeLM contextual percentile 0.87; strong pocket/AF2Bind evidence /main_page_ml/ML0411 2026-05-30T13:09:52Z 409 ML2197 Q7APX8 ML2197 Integral membrane protein 161 70.763 Strong candidate 0.8127 ProteomeLM contextual shift 0.17479265 1.0 32 1.0 500 34 0.781 0.8695 86.95 0.0 0.8625 ProteomeLM contextual percentile 0.81; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML2197 2026-05-30T13:09:52Z 410 ML2461 Q9CB39 fadB2 ML2461 3-hydroxyacyl-CoA dehydrogenase 287 70.763 Strong candidate 0.5689 ProteomeLM contextual shift 0.111831196 1.0 88 1.0 951 180 0.9552 0.925 92.5 0.33 1.0 PATHWAY: Lipid metabolism; butanoate metabolism. {ECO:0000256|ARBA:ARBA00005086}. nad, lipid metabolism, dehydrogenase ProteomeLM contextual percentile 0.57; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: nad, lipid metabolism, dehydrogenase /main_page_ml/ML2461 2026-05-30T13:09:52Z 411 ML0066 Q9CDD2 ML0066 Putative 4-hydroxy-4-methyl-2-oxoglutarate aldolase (HMG aldolase) (EC 4.1.3.17) (Oxaloacetate decarboxylase) (OAA decarboxylase) (EC 4.1.1.112) (Regulator of ribonuclease activity homolog) (RraA-like protein) 157 70.711 Strong candidate 0.468 ProteomeLM contextual shift 0.09981502 1.0 68 1.0 475 8 0.5218 0.973 97.3 0.48 1.0 4.1.1.112; 4.1.3.17 cofactor ProteomeLM contextual percentile 0.47; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model; matched: cofactor /main_page_ml/ML0066 2026-05-30T13:09:52Z 412 ML0700 Q9CCL9 add ML0700 L308_C2_206 Adenosine deaminase (EC 3.5.4.4) (Adenosine aminohydrolase) 362 70.708 Strong candidate 0.4768 ProteomeLM contextual shift 0.10070544 1.0 30 1.0 1128 84 0.9791 0.942 94.2 0.48 1.0 3.5.4.4 hydrolase, cofactor ProteomeLM contextual percentile 0.48; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model; matched: hydrolase, cofactor /main_page_ml/ML0700 2026-05-30T13:09:52Z 413 ML1275 Q9CC51 ML1275 Uncharacterized protein 78 70.705 Strong candidate 0.948 ProteomeLM contextual shift 0.5572537 1.0 12 1.0 250 32 0.8442 0.495 49.5 0.0 0.7575 ProteomeLM contextual percentile 0.95; strong pocket/AF2Bind evidence /main_page_ml/ML1275 2026-05-30T13:09:52Z 414 ML1176 P54133 ML1176 B1549_F2_59 MLCB1701.02c Uncharacterized protein ML1176 119 70.698 Strong candidate 0.8102 ProteomeLM contextual shift 0.17334476 1.0 12 1.0 379 44 0.9073 0.8168 81.68 0.08 0.7575 ProteomeLM contextual percentile 0.81; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML1176 2026-05-30T13:09:52Z 415 ML0053 Q7AQP0 ML0053 Membrane protein 744 70.693 Strong candidate 0.7431 ProteomeLM contextual shift 0.14744698 1.0 124 1.0 2292 0 0.4573 0.7059 70.59 0.2 0.8625 ProteomeLM contextual percentile 0.74; strong pocket/AF2Bind evidence /main_page_ml/ML0053 2026-05-30T13:09:52Z 416 ML1543 Q7AQ47 ML1543 Possible SpoIIIE-family membrane protein 1345 70.691 Strong candidate 0.7688 ProteomeLM contextual shift 0.15773383 1.0 231 1.0 1365 0 0.4362 0.7808 78.08 0.2 0.6975 ProteomeLM contextual percentile 0.77; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML1543 2026-05-30T13:09:52Z 417 ML1618 O33014 rpsP ML1618 MLCB250.32 Small ribosomal subunit protein bS16 (30S ribosomal protein S16) 160 70.671 Strong candidate 0.7531 ProteomeLM contextual shift 0.15058093 1.0 10 1.0 492 24 0.8812 0.6387 63.87 0.215 0.8625 translation, ribosome, ribosomal ProteomeLM contextual percentile 0.75; strong pocket/AF2Bind evidence; matched: translation, ribosome, ribosomal /main_page_ml/ML1618 2026-05-30T13:09:52Z 418 ML0964 Q9CCC3 ML0964 Uncharacterized protein 85 70.665 Strong candidate 0.9687 ProteomeLM contextual shift 0.6608387 1.0 10 1.0 271 32 0.7857 0.4186 41.86 0.0 0.7575 ProteomeLM contextual percentile 0.97; strong pocket/AF2Bind evidence /main_page_ml/ML0964 2026-05-30T13:09:52Z 419 ML0124 Q9CD92 ML0124 Coenzyme Q-binding protein COQ10 START domain-containing protein 146 70.644 Strong candidate 0.76 ProteomeLM contextual shift 0.15307105 1.0 22 1.0 329 74 0.9863 0.9043 90.43 0.0 1.0 enzyme ProteomeLM contextual percentile 0.76; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: enzyme /main_page_ml/ML0124 2026-05-30T13:09:52Z 420 ML0813 Q9CCH2 ML0813 Membrane protein 195 70.641 Strong candidate 0.8402 ProteomeLM contextual shift 0.197999 1.0 18 1.0 604 38 0.9324 0.6009 60.09 0.08 0.8625 ProteomeLM contextual percentile 0.84; strong pocket/AF2Bind evidence /main_page_ml/ML0813 2026-05-30T13:09:52Z 421 ML0620 Q49771 mtb12 ML0620 B1937_F3_91 Low molecular weight antigen MTB12 homolog 167 70.633 Strong candidate 0.8264 ProteomeLM contextual shift 0.18490194 1.0 28 1.0 522 42 0.8645 0.6483 64.83 0.08 0.8625 ProteomeLM contextual percentile 0.83; strong pocket/AF2Bind evidence /main_page_ml/ML0620 2026-05-30T13:09:52Z 422 ML2178 Q9CBD0 ML2178 VapC45 PIN like domain-containing protein 83 70.631 Strong candidate 0.9467 ProteomeLM contextual shift 0.552325 1.0 20 1.0 280 62 0.865 0.492 49.2 0.0 0.7575 ProteomeLM contextual percentile 0.95; strong pocket/AF2Bind evidence /main_page_ml/ML2178 2026-05-30T13:09:52Z 423 ML0699 Q9CCM0 sdhC ML0699 Succinate dehydrogenase cytochrome B-556 subunit 153 70.628 Strong candidate 0.782 ProteomeLM contextual shift 0.16188139 1.0 32 1.0 318 24 0.7641 0.666 66.6 0.08 1.0 dehydrogenase, cofactor ProteomeLM contextual percentile 0.78; strong pocket/AF2Bind evidence; matched: dehydrogenase, cofactor /main_page_ml/ML0699 2026-05-30T13:09:52Z 424 ML0996 P46814 dapF ML0996 B2235_C3_233 Diaminopimelate epimerase (DAP epimerase) (EC 5.1.1.7) (PLP-independent amino acid racemase) 296 70.62 Strong candidate 0.3866 ProteomeLM contextual shift 0.09081314 1.0 44 1.0 911 46 0.9658 0.9289 92.89 0.64 1.0 5.1.1.7 PATHWAY: Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; DL-2,6-diaminopimelate from LL-2,6-diaminopimelate: step 1/1. {ECO:0000255|HAMAP-Rule:MF_00197}. ProteomeLM contextual percentile 0.39; strong pocket/AF2Bind evidence; essential-process annotation; high-confidence Boltz2 model /main_page_ml/ML0996 2026-05-30T13:09:52Z 425 ML1730 Q9CBQ3 adhA ML1730 NADP-dependent alcohol dehydrogenase C (EC 1.1.1.2) 362 70.611 Strong candidate 0.5213 ProteomeLM contextual shift 0.10518299 1.0 92 1.0 1171 170 0.9905 0.9265 92.65 0.405 1.0 1.1.1.2 nad, dehydrogenase, cofactor ProteomeLM contextual percentile 0.52; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model; matched: nad, dehydrogenase, cofactor /main_page_ml/ML1730 2026-05-30T13:09:52Z 426 ML0728 P46700 sseA ML0728 B1308_C1_127 Putative thiosulfate sulfurtransferase SseA (EC 2.8.1.1) 296 70.593 Strong candidate 0.4787 ProteomeLM contextual shift 0.100834034 1.0 88 1.0 598 12 0.8691 0.9238 92.38 0.48 1.0 2.8.1.1 transferase ProteomeLM contextual percentile 0.48; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model; matched: transferase /main_page_ml/ML0728 2026-05-30T13:09:52Z 427 ML1832 O33007 adk ML1832 MLCB2492.28 Adenylate kinase (AK) (EC 2.7.4.3) (ATP-AMP transphosphorylase) (ATP:AMP phosphotransferase) (Adenylate monophosphate kinase) 181 70.572 Strong candidate 0.396 ProteomeLM contextual shift 0.092122875 1.0 30 1.0 393 62 0.989 0.8913 89.13 0.64 1.0 2.7.4.3 PATHWAY: Purine metabolism; AMP biosynthesis via salvage pathway; AMP from ADP: step 1/1. {ECO:0000255|HAMAP-Rule:MF_00235}. kinase, transferase ProteomeLM contextual percentile 0.40; strong pocket/AF2Bind evidence; essential-process annotation; high-confidence Boltz2 model; matched: kinase, transferase /main_page_ml/ML1832 2026-05-30T13:09:52Z 428 ML1264 Q9X7C3 hisI ML1264 MLCB1610.27 Phosphoribosyl-AMP cyclohydrolase (PRA-CH) (EC 3.5.4.19) 115 70.57 Strong candidate 0.4048 ProteomeLM contextual shift 0.09291703 1.0 32 1.0 390 90 0.9529 0.9654 96.54 0.64 0.895 3.5.4.19 PATHWAY: Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 3/9. {ECO:0000255|HAMAP-Rule:MF_01021}. hydrolase, cofactor ProteomeLM contextual percentile 0.40; strong pocket/AF2Bind evidence; essential-process annotation; high-confidence Boltz2 model; matched: hydrolase, cofactor /main_page_ml/ML1264 2026-05-30T13:09:52Z 429 ML2312 Q9CB83 ML2312 Possible membrane protein 196 70.565 Strong candidate 0.891 ProteomeLM contextual shift 0.28911301 1.0 24 1.0 616 56 0.9554 0.5756 57.56 0.0 0.8625 ProteomeLM contextual percentile 0.89; strong pocket/AF2Bind evidence /main_page_ml/ML2312 2026-05-30T13:09:52Z 430 ML1793 Q9CBN0 ML1793 Uncharacterized protein 101 70.546 Strong candidate 0.9461 ProteomeLM contextual shift 0.5516647 1.0 12 1.0 352 98 0.9719 0.4856 48.56 0.0 0.7575 ProteomeLM contextual percentile 0.95; strong pocket/AF2Bind evidence /main_page_ml/ML1793 2026-05-30T13:09:52Z 431 ML0845 Q7AQF1 ML0845 Acyl-CoA oxidase C-terminal domain-containing protein 193 70.544 Strong candidate 0.854 ProteomeLM contextual shift 0.21160856 1.0 36 1.0 632 106 0.9884 0.5428 54.28 0.08 0.8625 ProteomeLM contextual percentile 0.85; strong pocket/AF2Bind evidence /main_page_ml/ML0845 2026-05-30T13:09:52Z 432 ML0056 Q9CDD6 ML0056 Uncharacterized protein 169 70.515 Strong candidate 0.9323 ProteomeLM contextual shift 0.49290487 1.0 18 1.0 536 18 0.688 0.4258 42.58 0.0 0.8625 ProteomeLM contextual percentile 0.93; strong pocket/AF2Bind evidence /main_page_ml/ML0056 2026-05-30T13:09:52Z 433 ML1692 O33116 serA ML1692 MLCB637.25 D-3-phosphoglycerate dehydrogenase (PGDH) (EC 1.1.1.95) (2-oxoglutarate reductase) (EC 1.1.1.399) 528 70.485 Strong candidate 0.3803 ProteomeLM contextual shift 0.09020797 1.0 188 1.0 1595 22 0.7589 0.8473 84.73 0.685 1.0 1.1.1.399; 1.1.1.95 PATHWAY: Amino-acid biosynthesis; L-serine biosynthesis; L-serine from 3-phospho-D-glycerate: step 1/3. nad, dehydrogenase, reductase ProteomeLM contextual percentile 0.38; strong pocket/AF2Bind evidence; essential-process annotation; high-confidence Boltz2 model; matched: nad, dehydrogenase, reductase /main_page_ml/ML1692 2026-05-30T13:09:52Z 434 ML0464 Q9CCT8 ML0464 Uncharacterized protein 95 70.484 Strong candidate 0.9568 ProteomeLM contextual shift 0.60291713 1.0 20 1.0 308 46 0.8679 0.4423 44.23 0.0 0.7575 ProteomeLM contextual percentile 0.96; strong pocket/AF2Bind evidence /main_page_ml/ML0464 2026-05-30T13:09:52Z 435 ML0888 Q7AQE1 ML0888 Polyketide cyclase / dehydrase and lipid transport 135 70.483 Strong candidate 0.8014 ProteomeLM contextual shift 0.16942117 1.0 16 1.0 427 4 0.6944 0.881 88.1 0.0 0.8625 ProteomeLM contextual percentile 0.80; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML0888 2026-05-30T13:09:52Z 436 ML0863 Q7AQE5 ML0863 Uncharacterized protein 104 70.467 Strong candidate 0.9543 ProteomeLM contextual shift 0.5915622 1.0 16 1.0 346 68 0.9942 0.4493 44.93 0.0 0.7575 ProteomeLM contextual percentile 0.95; strong pocket/AF2Bind evidence /main_page_ml/ML0863 2026-05-30T13:09:52Z 437 ML1270 Q9CC55 ML1270 Possible conserved membrane protein 265 70.459 Strong candidate 0.8628 ProteomeLM contextual shift 0.22392964 1.0 12 1.0 836 2 0.516 0.6637 66.37 0.0 0.8625 ProteomeLM contextual percentile 0.86; strong pocket/AF2Bind evidence /main_page_ml/ML1270 2026-05-30T13:09:52Z 438 ML1995 Q9CBG2 ML1995 Carrier domain-containing protein 78 70.453 Strong candidate 0.812 ProteomeLM contextual shift 0.17444335 1.0 8 1.0 239 10 0.8482 0.9457 94.57 0.0 0.7575 ProteomeLM contextual percentile 0.81; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML1995 2026-05-30T13:09:52Z 439 ML1037 Q7AQA5 ML1037 CBS domain-containing protein 184 70.449 Strong candidate 0.8459 ProteomeLM contextual shift 0.20103168 1.0 22 1.0 562 20 0.6631 0.7218 72.18 0.0 0.8625 ProteomeLM contextual percentile 0.85; strong pocket/AF2Bind evidence /main_page_ml/ML1037 2026-05-30T13:09:52Z 440 ML0633 Q9CCN0 recO ML0633 B1937_F1_25 DNA repair protein RecO (Recombination protein O) 268 70.414 Strong candidate 0.7625 ProteomeLM contextual shift 0.15455206 1.0 38 1.0 834 20 0.8151 0.85 85.0 0.08 0.8625 ProteomeLM contextual percentile 0.76; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML0633 2026-05-30T13:09:52Z 441 ML0576 Q7AQI3 ML0576 Uncharacterized protein 76 70.407 Strong candidate 0.9236 ProteomeLM contextual shift 0.45582318 1.0 14 1.0 236 16 0.7655 0.5508 55.08 0.0 0.7575 ProteomeLM contextual percentile 0.92; strong pocket/AF2Bind evidence /main_page_ml/ML0576 2026-05-30T13:09:52Z 442 ML1514 Q9CBW3 thyX ML1514 Flavin-dependent thymidylate synthase (FDTS) (EC 2.1.1.148) (FAD-dependent thymidylate synthase) (Thymidylate synthase ThyX) (TS) (TSase) 254 70.395 Strong candidate 0.3358 ProteomeLM contextual shift 0.08392593 1.0 84 1.0 822 0 0.4447 0.9041 90.41 0.73 1.0 2.1.1.148 PATHWAY: Pyrimidine metabolism; dTTP biosynthesis. {ECO:0000255|HAMAP-Rule:MF_01408}. folate, nad, synthase, binding site, cofactor ProteomeLM contextual percentile 0.34; strong pocket/AF2Bind evidence; essential-process annotation; high-confidence Boltz2 model; matched: folate, nad, synthase, binding site, cofactor /main_page_ml/ML1514 2026-05-30T13:09:52Z 443 ML0777 Q9CCI8 ML0777 Uncharacterized protein 64 70.394 Strong candidate 0.9373 ProteomeLM contextual shift 0.51883906 1.0 8 1.0 208 32 0.8403 0.5012 50.12 0.0 0.7575 ProteomeLM contextual percentile 0.94; strong pocket/AF2Bind evidence /main_page_ml/ML0777 2026-05-30T13:09:52Z 444 ML1140 P45828 atpE ML1140 ATP synthase subunit c (ATP synthase F(0) sector subunit c) (F-type ATPase subunit c) (F-ATPase subunit c) (Lipid-binding protein) 81 70.381 Strong candidate 0.7118 ProteomeLM contextual shift 0.14014715 1.0 8 1.0 276 66 0.8293 0.9019 90.19 0.125 0.895 atp synthase, synthase ProteomeLM contextual percentile 0.71; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: atp synthase, synthase /main_page_ml/ML1140 2026-05-30T13:09:52Z 445 ML0188 Q9CD63 ML0188 DUF5642 domain-containing protein 87 70.346 Strong candidate 0.9336 ProteomeLM contextual shift 0.49822026 1.0 14 1.0 209 70 0.9345 0.5095 50.95 0.0 0.7575 ProteomeLM contextual percentile 0.93; strong pocket/AF2Bind evidence /main_page_ml/ML0188 2026-05-30T13:09:52Z 446 ML1147 P53432 ML1147 u471b Uncharacterized protein ML1147 147 70.338 Strong candidate 0.7751 ProteomeLM contextual shift 0.15957148 1.0 14 1.0 482 2 0.5676 0.7986 79.86 0.08 0.8625 ProteomeLM contextual percentile 0.78; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML1147 2026-05-30T13:09:52Z 447 ML1141 P45827 atpF ML1141 ATP synthase subunit b (ATP synthase F(0) sector subunit b) (ATPase subunit I) (F-type ATPase subunit b) (F-ATPase subunit b) 170 70.334 Strong candidate 0.8001 ProteomeLM contextual shift 0.16936293 1.0 12 1.0 532 44 0.8516 0.4829 48.29 0.125 1.0 atp synthase, synthase ProteomeLM contextual percentile 0.80; strong pocket/AF2Bind evidence; matched: atp synthase, synthase /main_page_ml/ML1141 2026-05-30T13:09:52Z 448 ML0308 Q7AQJ8 ML0308 Methyltransferase type 11 domain-containing protein 234 70.331 Strong candidate 0.7456 ProteomeLM contextual shift 0.14850524 1.0 30 1.0 769 134 0.9704 0.9234 92.34 0.0 1.0 transferase ProteomeLM contextual percentile 0.75; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: transferase /main_page_ml/ML0308 2026-05-30T13:09:52Z 449 ML2054 Q9CBF0 ML2054 Integral membrane protein 99 70.325 Strong candidate 0.8114 ProteomeLM contextual shift 0.17434675 1.0 17 1.0 341 88 0.9484 0.7751 77.51 0.08 0.7575 ProteomeLM contextual percentile 0.81; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML2054 2026-05-30T13:09:52Z 450 ML0588 Q7AQI0 ML0588 PPE-PPW subfamily C-terminal domain-containing protein 80 70.322 Strong candidate 0.9712 ProteomeLM contextual shift 0.68138355 1.0 12 1.0 275 70 0.841 0.3756 37.56 0.0 0.7575 ProteomeLM contextual percentile 0.97; strong pocket/AF2Bind evidence /main_page_ml/ML0588 2026-05-30T13:09:52Z 451 ML1858 O32986 rplV ML1858 MLCB2492.07 Large ribosomal subunit protein uL22 (50S ribosomal protein L22) 175 70.286 Strong candidate 0.7318 ProteomeLM contextual shift 0.14537016 1.0 20 1.0 542 34 0.8742 0.6747 67.47 0.215 0.8625 translation, ribosome, ribosomal ProteomeLM contextual percentile 0.73; strong pocket/AF2Bind evidence; matched: translation, ribosome, ribosomal /main_page_ml/ML1858 2026-05-30T13:09:52Z 452 ML1292 Q7AQ76 ML1292 Uncharacterized protein 80 70.267 Strong candidate 0.9511 ProteomeLM contextual shift 0.56456995 1.0 10 1.0 262 44 0.8089 0.4403 44.03 0.0 0.7575 ProteomeLM contextual percentile 0.95; strong pocket/AF2Bind evidence /main_page_ml/ML1292 2026-05-30T13:09:52Z 453 ML0573 Q7AQI5 ML0573 Uncharacterized protein 91 70.252 Strong candidate 0.911 ProteomeLM contextual shift 0.38646623 1.0 12 1.0 345 104 0.927 0.5791 57.91 0.0 0.7575 ProteomeLM contextual percentile 0.91; strong pocket/AF2Bind evidence /main_page_ml/ML0573 2026-05-30T13:09:52Z 454 ML2091 Q9CBE6 ML2091 Uncharacterized protein 61 70.251 Strong candidate 0.9317 ProteomeLM contextual shift 0.49281684 1.0 59 1.0 240 114 0.868 0.5066 50.66 0.0 0.7575 ProteomeLM contextual percentile 0.93; strong pocket/AF2Bind evidence /main_page_ml/ML2091 2026-05-30T13:09:52Z 455 ML1828 Q7AQ23 PPE ML1828 PPE-family protein 572 70.236 Strong candidate 0.8678 ProteomeLM contextual shift 0.23818602 1.0 94 1.0 1743 14 0.8191 0.4638 46.38 0.08 0.8625 ProteomeLM contextual percentile 0.87; strong pocket/AF2Bind evidence /main_page_ml/ML1828 2026-05-30T13:09:52Z 456 ML2422 P46724 hemA ML2422 B2168_C3_261 Glutamyl-tRNA reductase (GluTR) (EC 1.2.1.70) 467 70.217 Strong candidate 0.3979 ProteomeLM contextual shift 0.092251495 1.0 78 1.0 1435 68 0.8727 0.7592 75.92 0.685 1.0 1.2.1.70 PATHWAY: Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; 5-aminolevulinate from L-glutamyl-tRNA(Glu): step 1/2. {ECO:0000255|HAMAP-Rule:MF_00087}. nad, reductase ProteomeLM contextual percentile 0.40; strong pocket/AF2Bind evidence; essential-process annotation; high-confidence Boltz2 model; matched: nad, reductase /main_page_ml/ML2422 2026-05-30T13:09:52Z 457 ML1669 O69462 ML1669 MLCB1243.03c Aldo-keto reductase ML1669 (EC 1.1.1.-) 282 70.207 Strong candidate 0.5019 ProteomeLM contextual shift 0.10327872 1.0 36 1.0 874 56 0.9144 0.9541 95.41 0.405 1.0 1.1.1.- nad, oxidoreductase, reductase ProteomeLM contextual percentile 0.50; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model; matched: nad, oxidoreductase, reductase /main_page_ml/ML1669 2026-05-30T13:09:52Z 458 ML1066 Q7AQ96 tagA ML1066 DNA-3-methyladenine glycosidase I 192 70.198 Strong candidate 0.6635 ProteomeLM contextual shift 0.12797399 1.0 24 1.0 595 38 0.8479 0.9349 93.49 0.2 0.8625 ProteomeLM contextual percentile 0.66; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML1066 2026-05-30T13:09:52Z 459 ML2010 Q7AQ06 ML2010 Lipoprotein 153 70.197 Strong candidate 0.8553 ProteomeLM contextual shift 0.21409601 1.0 18 1.0 328 4 0.5958 0.6638 66.38 0.0 0.8625 ProteomeLM contextual percentile 0.86; strong pocket/AF2Bind evidence /main_page_ml/ML2010 2026-05-30T13:09:52Z 460 ML2201 Q9CBC5 ML2201 Uncharacterized protein 79 70.193 Strong candidate 0.9593 ProteomeLM contextual shift 0.61344624 1.0 10 1.0 272 70 0.8925 0.4043 40.43 0.0 0.7575 ProteomeLM contextual percentile 0.96; strong pocket/AF2Bind evidence /main_page_ml/ML2201 2026-05-30T13:09:52Z 461 ML2170 Q9CBD5 ML2170 Uncharacterized protein 74 70.189 Strong candidate 0.9492 ProteomeLM contextual shift 0.5607581 1.0 14 1.0 255 66 0.9397 0.439 43.9 0.0 0.7575 ProteomeLM contextual percentile 0.95; strong pocket/AF2Bind evidence /main_page_ml/ML2170 2026-05-30T13:09:52Z 462 ML0946 Q7AQC3 ML0946 Uncharacterized protein 107 70.189 Strong candidate 0.9436 ProteomeLM contextual shift 0.54093796 1.0 19 1.0 360 78 0.8583 0.4588 45.88 0.0 0.7575 ProteomeLM contextual percentile 0.94; strong pocket/AF2Bind evidence /main_page_ml/ML0946 2026-05-30T13:09:52Z 463 ML0734 Q7AQF6 ML0734 Membrane protein 228 70.187 Strong candidate 0.7989 ProteomeLM contextual shift 0.16902286 1.0 36 1.0 754 140 0.9728 0.7002 70.02 0.08 0.8625 ProteomeLM contextual percentile 0.80; strong pocket/AF2Bind evidence /main_page_ml/ML0734 2026-05-30T13:09:52Z 464 ML1186 Q9CC71 ML1186 Uncharacterized protein 100 70.138 Strong candidate 0.9724 ProteomeLM contextual shift 0.6892432 1.0 14 1.0 345 90 0.9688 0.3528 35.28 0.0 0.7575 ProteomeLM contextual percentile 0.97; strong pocket/AF2Bind evidence /main_page_ml/ML1186 2026-05-30T13:09:52Z 465 ML1979 Q9CBH3 ML1979 Uncharacterized protein 135 70.138 Strong candidate 0.9405 ProteomeLM contextual shift 0.5240312 1.0 12 1.0 451 92 0.9804 0.3596 35.96 0.0 0.8625 ProteomeLM contextual percentile 0.94; strong pocket/AF2Bind evidence /main_page_ml/ML1979 2026-05-30T13:09:52Z 466 ML2463 Q9CB38 ML2463 Acyl-ACP thioesterase 264 70.131 Strong candidate 0.6898 ProteomeLM contextual shift 0.1322018 1.0 52 1.0 827 70 0.8894 0.9386 93.86 0.08 1.0 hydrolase ProteomeLM contextual percentile 0.69; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: hydrolase /main_page_ml/ML2463 2026-05-30T13:09:52Z 467 ML0217 Q9CD59 ML0217 Uncharacterized protein 81 70.098 Strong candidate 0.9411 ProteomeLM contextual shift 0.53210104 1.0 10 1.0 212 100 0.9599 0.4584 45.84 0.0 0.7575 ProteomeLM contextual percentile 0.94; strong pocket/AF2Bind evidence /main_page_ml/ML0217 2026-05-30T13:09:52Z 468 ML1523 Q9CBV9 ML1523 Transmembrane protein 96 70.082 Strong candidate 0.9242 ProteomeLM contextual shift 0.45595044 1.0 14 1.0 335 94 0.8853 0.5161 51.61 0.0 0.7575 ProteomeLM contextual percentile 0.92; strong pocket/AF2Bind evidence /main_page_ml/ML1523 2026-05-30T13:09:52Z 469 ML2468 Q9CB35 ML2468 Uncharacterized protein 126 70.077 Strong candidate 0.9499 ProteomeLM contextual shift 0.561128 1.0 10 1.0 426 96 0.9872 0.3207 32.07 0.0 0.8625 ProteomeLM contextual percentile 0.95; strong pocket/AF2Bind evidence /main_page_ml/ML2468 2026-05-30T13:09:52Z 470 ML1997 Q9CBG1 ML1997 Probable integral membrane protein 210 70.074 Strong candidate 0.8828 ProteomeLM contextual shift 0.26488838 1.0 54 1.0 452 64 0.917 0.555 55.5 0.0 0.8625 ProteomeLM contextual percentile 0.88; strong pocket/AF2Bind evidence /main_page_ml/ML1997 2026-05-30T13:09:52Z 471 ML1232 Q9CC62 ML1232 PE-PPE domain-containing protein 358 70.072 Strong candidate 0.7901 ProteomeLM contextual shift 0.16532643 1.0 50 1.0 1152 156 0.985 0.8794 87.94 0.0 0.8625 ProteomeLM contextual percentile 0.79; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML1232 2026-05-30T13:09:52Z 472 ML0265 Q7AQK9 ML0265 Uncharacterized protein 70 70.07 Strong candidate 0.9048 ProteomeLM contextual shift 0.35568482 1.0 10 1.0 219 18 0.7913 0.5828 58.28 0.0 0.7575 ProteomeLM contextual percentile 0.90; strong pocket/AF2Bind evidence /main_page_ml/ML0265 2026-05-30T13:09:52Z 473 ML2023 Q7AQ02 ML2023 Secreted protein 134 70.059 Strong candidate 0.8214 ProteomeLM contextual shift 0.18162614 1.0 36 1.0 446 88 0.9678 0.7684 76.84 0.0 0.8625 ProteomeLM contextual percentile 0.82; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML2023 2026-05-30T13:09:52Z 474 ML0049 Q50206 esxA esaT6 esx L45 ML0049 MLCB628.12c 6 kDa early secretory antigenic target homolog (ESAT-6-like protein) (L-ESAT) 95 70.034 Strong candidate 0.8233 ProteomeLM contextual shift 0.18243906 1.0 8 1.0 297 24 0.7516 0.7043 70.43 0.08 0.7575 ProteomeLM contextual percentile 0.82; strong pocket/AF2Bind evidence /main_page_ml/ML0049 2026-05-30T13:09:52Z 475 ML0154 Q9CD71 ML0154 M23ase beta-sheet core domain-containing protein 333 70.028 Strong candidate 0.8415 ProteomeLM contextual shift 0.19840771 1.0 36 1.0 1005 12 0.6564 0.5351 53.51 0.08 0.8625 ProteomeLM contextual percentile 0.84; strong pocket/AF2Bind evidence /main_page_ml/ML0154 2026-05-30T13:09:52Z 476 ML0044 Q7AQP2 ML0044 ML0044 protein 113 70.017 Strong candidate 0.7757 ProteomeLM contextual shift 0.15993223 1.0 10 1.0 353 28 0.8161 0.8693 86.93 0.08 0.7575 ProteomeLM contextual percentile 0.78; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML0044 2026-05-30T13:09:52Z 477 ML2000 P46840 ctpB ML2000 Cation-transporting P-type ATPase B (EC 7.2.2.-) 750 69.997 Strong candidate 0.5119 ProteomeLM contextual shift 0.10420981 1.0 209 1.0 1522 4 0.608 0.748 74.8 0.48 1.0 7.2.2.- ProteomeLM contextual percentile 0.51; strong pocket/AF2Bind evidence; functional annotation support /main_page_ml/ML2000 2026-05-30T13:09:52Z 478 ML2406 O07134 menA ML2406 MLB1306.02c 1,4-dihydroxy-2-naphthoate octaprenyltransferase (DHNA-octaprenyltransferase) (EC 2.5.1.74) 294 69.982 Strong candidate 0.4079 ProteomeLM contextual shift 0.09307259 1.0 48 1.0 933 102 0.9867 0.9406 94.06 0.565 1.0 2.5.1.74 PATHWAY: Quinol/quinone metabolism; menaquinone biosynthesis; menaquinol from 1,4-dihydroxy-2-naphthoate: step 1/2. {ECO:0000255|HAMAP-Rule:MF_01937}. menaquinone, transferase ProteomeLM contextual percentile 0.41; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model; matched: menaquinone, transferase /main_page_ml/ML2406 2026-05-30T13:09:52Z 479 ML1384 Q9CC28 ML1384 Uncharacterized protein 112 69.938 Strong candidate 0.968 ProteomeLM contextual shift 0.65728605 1.0 14 1.0 389 106 0.9562 0.3482 34.82 0.0 0.7575 ProteomeLM contextual percentile 0.97; strong pocket/AF2Bind evidence /main_page_ml/ML1384 2026-05-30T13:09:52Z 480 ML2313 Q9CB82 ML2313 Transcription regulator PadR N-terminal domain-containing protein 200 69.936 Strong candidate 0.8271 ProteomeLM contextual shift 0.18518932 1.0 22 1.0 652 104 0.9784 0.6463 64.63 0.045 0.8625 transcription ProteomeLM contextual percentile 0.83; strong pocket/AF2Bind evidence; matched: transcription /main_page_ml/ML2313 2026-05-30T13:09:52Z 481 ML1209 Q9X7F1 ilvA ML1209 L-threonine dehydratase biosynthetic IlvA (EC 4.3.1.19) (Threonine deaminase) 427 69.921 Strong candidate 0.3747 ProteomeLM contextual shift 0.08929874 1.0 58 1.0 890 72 0.9629 0.9007 90.07 0.64 1.0 4.3.1.19 PATHWAY: Amino-acid biosynthesis; L-isoleucine biosynthesis; 2-oxobutanoate from L-threonine: step 1/1. lyase, cofactor ProteomeLM contextual percentile 0.37; strong pocket/AF2Bind evidence; essential-process annotation; high-confidence Boltz2 model; matched: lyase, cofactor /main_page_ml/ML1209 2026-05-30T13:09:52Z 482 ML0659 Q7AQH0 ML0659 Uncharacterized protein 108 69.917 Strong candidate 0.9649 ProteomeLM contextual shift 0.65047294 1.0 22 1.0 374 100 0.9856 0.357 35.7 0.0 0.7575 ProteomeLM contextual percentile 0.96; strong pocket/AF2Bind evidence /main_page_ml/ML0659 2026-05-30T13:09:52Z 483 ML1518 Q9CBW1 folA ML1518 Dihydrofolate reductase (EC 1.5.1.3) 165 69.914 Strong candidate 0.2832 ProteomeLM contextual shift 0.077642255 1.0 34 1.0 586 182 0.9989 0.9502 95.02 0.775 1.0 1.5.1.3 PATHWAY: Cofactor biosynthesis; tetrahydrofolate biosynthesis; 5,6,7,8-tetrahydrofolate from 7,8-dihydrofolate: step 1/1. folate, nad, cofactor biosynthesis, reductase, cofactor ProteomeLM contextual percentile 0.28; strong pocket/AF2Bind evidence; essential-process annotation; high-confidence Boltz2 model; matched: folate, nad, cofactor biosynthesis, reductase, cofactor /main_page_ml/ML1518 2026-05-30T13:09:52Z 484 ML0335 Q9CCW1 ML0335 ABC-transporter transmembrane protein 286 69.868 Strong candidate 0.7506 ProteomeLM contextual shift 0.14982577 1.0 64 1.0 612 0 0.3545 0.8371 83.71 0.08 0.8625 ProteomeLM contextual percentile 0.75; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML0335 2026-05-30T13:09:52Z 485 ML1513 Q9CBW4 dapA ML1513 4-hydroxy-tetrahydrodipicolinate synthase (HTPA synthase) (EC 4.3.3.7) 300 69.857 Strong candidate 0.3546 ProteomeLM contextual shift 0.086569116 1.0 68 1.0 981 162 0.9917 0.9645 96.45 0.64 1.0 4.3.3.7 PATHWAY: Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 3/4. {ECO:0000255|HAMAP-Rule:MF_00418}. synthase ProteomeLM contextual percentile 0.35; strong pocket/AF2Bind evidence; essential-process annotation; high-confidence Boltz2 model; matched: synthase /main_page_ml/ML1513 2026-05-30T13:09:52Z 486 ML0280 O69595 purA ML0280 MLCB4.23c Adenylosuccinate synthetase (AMPSase) (AdSS) (EC 6.3.4.4) (IMP--aspartate ligase) 432 69.846 Strong candidate 0.3697 ProteomeLM contextual shift 0.08866299 1.0 78 1.0 1305 18 0.639 0.9108 91.08 0.64 1.0 6.3.4.4 PATHWAY: Purine metabolism; AMP biosynthesis via de novo pathway; AMP from IMP: step 1/2. {ECO:0000255|HAMAP-Rule:MF_00011}. ligase, synthetase, synthase ProteomeLM contextual percentile 0.37; strong pocket/AF2Bind evidence; essential-process annotation; high-confidence Boltz2 model; matched: ligase, synthetase, synthase /main_page_ml/ML0280 2026-05-30T13:09:52Z 487 ML1323 Q9S375 prcA ML1323 B2126_C3_260 Proteasome subunit alpha (20S proteasome alpha subunit) (Proteasome core protein PrcA) 265 69.828 Strong candidate 0.6397 ProteomeLM contextual shift 0.12303663 1.0 38 1.0 799 8 0.742 0.8112 81.12 0.285 0.8625 PATHWAY: Protein degradation; proteasomal Pup-dependent pathway. {ECO:0000255|HAMAP-Rule:MF_00289}. proteasome ProteomeLM contextual percentile 0.64; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: proteasome /main_page_ml/ML1323 2026-05-30T13:09:52Z 488 ML1581 Q9CBU5 ispG gcpE ML1581 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (flavodoxin) (EC 1.17.7.3) (1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase) 392 69.825 Strong candidate 0.3615 ProteomeLM contextual shift 0.0874779 1.0 70 1.0 1207 62 0.8694 0.8472 84.72 0.685 1.0 1.17.7.3 PATHWAY: Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 5/6. {ECO:0000255|HAMAP-Rule:MF_00159}. isoprenoid, synthase, cofactor ProteomeLM contextual percentile 0.36; strong pocket/AF2Bind evidence; essential-process annotation; high-confidence Boltz2 model; matched: isoprenoid, synthase, cofactor /main_page_ml/ML1581 2026-05-30T13:09:52Z 489 ML2284 Q9CBA1 ML2284 Uncharacterized protein 119 69.821 Strong candidate 0.9029 ProteomeLM contextual shift 0.3356169 1.0 16 1.0 266 56 0.9876 0.5645 56.45 0.0 0.7575 ProteomeLM contextual percentile 0.90; strong pocket/AF2Bind evidence /main_page_ml/ML2284 2026-05-30T13:09:52Z 490 ML0947 Q9CCD2 ML0947 Uncharacterized protein 85 69.815 Strong candidate 0.9449 ProteomeLM contextual shift 0.5450997 1.0 12 1.0 308 106 0.9628 0.4169 41.69 0.0 0.7575 ProteomeLM contextual percentile 0.94; strong pocket/AF2Bind evidence /main_page_ml/ML0947 2026-05-30T13:09:52Z 491 ML0844 Q7AQF2 narK ML0844 Nitrite extrusion protein 517 69.813 Strong candidate 0.7569 ProteomeLM contextual shift 0.15207516 1.0 94 1.0 1569 36 0.8467 0.8097 80.97 0.08 0.8625 ProteomeLM contextual percentile 0.76; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML0844 2026-05-30T13:09:52Z 492 ML1735 Q9CBP9 nrdI ML1735 Protein NrdI 138 69.803 Strong candidate 0.7293 ProteomeLM contextual shift 0.14459606 1.0 22 1.0 444 60 0.92 0.9052 90.52 0.08 0.8625 ProteomeLM contextual percentile 0.73; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML1735 2026-05-30T13:09:52Z 493 ML0922 P46815 wag31 ag84 ML0922 Cell wall synthesis protein Wag31 (Antigen 84) 266 69.794 Strong candidate 0.7857 ProteomeLM contextual shift 0.16303758 1.0 16 1.0 840 4 0.6055 0.5269 52.69 0.17 0.8625 cell division, cell wall ProteomeLM contextual percentile 0.79; strong pocket/AF2Bind evidence; matched: cell division, cell wall /main_page_ml/ML0922 2026-05-30T13:09:52Z 494 ML1605 Q9CBT6 ML1605 Uncharacterized protein 66 69.789 Strong candidate 0.9455 ProteomeLM contextual shift 0.5502043 1.0 10 1.0 239 82 0.9875 0.4122 41.22 0.0 0.7575 ProteomeLM contextual percentile 0.95; strong pocket/AF2Bind evidence /main_page_ml/ML1605 2026-05-30T13:09:52Z 495 ML0162 Q7AQN3 ML0162 Uncharacterized protein 92 69.789 Strong candidate 0.9424 ProteomeLM contextual shift 0.537292 1.0 10 1.0 323 94 0.9385 0.4232 42.32 0.0 0.7575 ProteomeLM contextual percentile 0.94; strong pocket/AF2Bind evidence /main_page_ml/ML0162 2026-05-30T13:09:52Z 496 ML1018 Q9CCB3 ML1018 Uncharacterized protein 71 69.787 Strong candidate 0.9618 ProteomeLM contextual shift 0.63325685 1.0 10 1.0 264 102 0.9713 0.3549 35.49 0.0 0.7575 ProteomeLM contextual percentile 0.96; strong pocket/AF2Bind evidence /main_page_ml/ML1018 2026-05-30T13:09:52Z 497 ML2059 Q7AQ00 ML2059 Short-chain dehydrogenase/reductase family 224 69.786 Strong candidate 0.6742 ProteomeLM contextual shift 0.12988909 1.0 40 1.0 709 74 0.8899 0.869 86.9 0.125 1.0 nad, oxidoreductase, dehydrogenase, reductase ProteomeLM contextual percentile 0.67; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: nad, oxidoreductase, dehydrogenase, reductase /main_page_ml/ML2059 2026-05-30T13:09:52Z 498 ML2198 Q50036 cysA cysA3 ML2198 Putative thiosulfate sulfurtransferase (EC 2.8.1.1) (Rhodanese-like protein) 277 69.78 Strong candidate 0.4499 ProteomeLM contextual shift 0.09756093 1.0 28 1.0 845 28 0.9129 0.9435 94.35 0.48 1.0 2.8.1.1 transferase ProteomeLM contextual percentile 0.45; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model; matched: transferase /main_page_ml/ML2198 2026-05-30T13:09:52Z 499 ML1481 Q9CBY2 tig ML1481 Trigger factor (TF) (EC 5.2.1.8) (PPIase) 469 69.775 Strong candidate 0.4843 ProteomeLM contextual shift 0.10142455 1.0 88 1.0 1431 48 0.8924 0.7924 79.24 0.495 1.0 5.2.1.8 translation, ribosome, cell division, isomerase ProteomeLM contextual percentile 0.48; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model; matched: translation, ribosome, cell division, isomerase /main_page_ml/ML1481 2026-05-30T13:09:52Z 500 ML0373 P37391 nnr ML0373 B229_C2_201 u229g Bifunctional NAD(P)H-hydrate repair enzyme Nnr (Nicotinamide nucleotide repair protein) [Includes: ADP-dependent (S)-NAD(P)H-hydrate dehydratase (EC 4.2.1.136) (ADP-dependent NAD(P)HX dehydratase); NAD(P)H-hydrate epimerase (EC 5.1.99.6) (NAD(P)HX epimerase)] 473 69.756 Strong candidate 0.4198 ProteomeLM contextual shift 0.09441962 1.0 52 1.0 1460 2 0.5396 0.9563 95.63 0.525 1.0 4.2.1.136; 5.1.99.6 nad, enzyme, cofactor ProteomeLM contextual percentile 0.42; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model; matched: nad, enzyme, cofactor /main_page_ml/ML0373 2026-05-30T13:09:52Z 501 ML0152 Q9CD73 ML0152 Uncharacterized protein 62 69.755 Strong candidate 0.9311 ProteomeLM contextual shift 0.49070206 1.0 10 1.0 224 36 0.8821 0.4593 45.93 0.0 0.7575 ProteomeLM contextual percentile 0.93; strong pocket/AF2Bind evidence /main_page_ml/ML0152 2026-05-30T13:09:52Z 502 ML2562 Q9CD23 ML2562 Uncharacterized protein 96 69.739 Strong candidate 0.9518 ProteomeLM contextual shift 0.57742727 1.0 14 1.0 318 60 0.9739 0.3853 38.53 0.0 0.7575 ProteomeLM contextual percentile 0.95; strong pocket/AF2Bind evidence /main_page_ml/ML2562 2026-05-30T13:09:52Z 503 ML1562 Q7AQ40 ML1562 Transmembrane efflux protein 534 69.736 Strong candidate 0.7525 ProteomeLM contextual shift 0.15009397 1.0 212 1.0 1638 72 0.8463 0.8173 81.73 0.08 0.8625 ProteomeLM contextual percentile 0.75; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML1562 2026-05-30T13:09:52Z 504 ML1752 Q9CBP4 ML1752 EAL domain-containing protein 302 69.721 Strong candidate 0.7638 ProteomeLM contextual shift 0.15560982 1.0 96 1.0 946 80 0.9035 0.7763 77.63 0.08 0.8625 ProteomeLM contextual percentile 0.76; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML1752 2026-05-30T13:09:52Z 505 ML1918 Q9CBJ2 ML1918 Conserved hypothetical membrane protein 263 69.697 Strong candidate 0.844 ProteomeLM contextual shift 0.19991437 1.0 24 1.0 551 10 0.8038 0.6533 65.33 0.0 0.8625 ProteomeLM contextual percentile 0.84; strong pocket/AF2Bind evidence /main_page_ml/ML1918 2026-05-30T13:09:52Z 506 ML0158 Q9CD70 ML0158 34 kDa antigen 314 69.673 Strong candidate 0.9104 ProteomeLM contextual shift 0.38442892 1.0 32 1.0 966 8 0.5636 0.4184 41.84 0.0 0.8625 ProteomeLM contextual percentile 0.91; strong pocket/AF2Bind evidence /main_page_ml/ML0158 2026-05-30T13:09:52Z 507 ML1445 Q9CC03 ML1445 Uncharacterized protein 74 69.662 Strong candidate 0.9386 ProteomeLM contextual shift 0.51952136 1.0 8 1.0 255 66 0.9649 0.4236 42.36 0.0 0.7575 ProteomeLM contextual percentile 0.94; strong pocket/AF2Bind evidence /main_page_ml/ML1445 2026-05-30T13:09:52Z 508 ML1446 Q9CC02 ML1446 Pyridoxamine 5'-phosphate oxidase N-terminal domain-containing protein 128 69.645 Strong candidate 0.6736 ProteomeLM contextual shift 0.1298591 1.0 26 1.0 421 74 0.9369 0.9471 94.71 0.08 1.0 enzyme, oxidoreductase, reductase ProteomeLM contextual percentile 0.67; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: enzyme, oxidoreductase, reductase /main_page_ml/ML1446 2026-05-30T13:09:52Z 509 ML0363 Q9CCV7 ML0363 ESAT-6-like protein 104 69.642 Strong candidate 0.9154 ProteomeLM contextual shift 0.4058831 1.0 8 1.0 356 88 0.9286 0.5028 50.28 0.0 0.7575 ProteomeLM contextual percentile 0.92; strong pocket/AF2Bind evidence /main_page_ml/ML0363 2026-05-30T13:09:52Z 510 ML1807 Q9CBM0 fabG1 ML1807 3-oxoacyl-[ACP] reductase (Aka MabA) 253 69.627 Strong candidate 0.656 ProteomeLM contextual shift 0.12671314 1.0 64 1.0 569 126 0.9834 0.9166 91.66 0.125 1.0 nad, oxidoreductase, dehydrogenase, reductase ProteomeLM contextual percentile 0.66; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: nad, oxidoreductase, dehydrogenase, reductase /main_page_ml/ML1807 2026-05-30T13:09:52Z 511 ML0961 O05564 metE ML0961 MLCB33.14 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase (EC 2.1.1.14) (Cobalamin-independent methionine synthase) (Methionine synthase, vitamin-B12 independent isozyme) 760 69.616 Strong candidate 0.3766 ProteomeLM contextual shift 0.08961632 1.0 106 1.0 2300 40 0.7147 0.9386 93.86 0.64 0.925 2.1.1.14 PATHWAY: Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-methionine from L-homocysteine (MetE route): step 1/1. {ECO:0000255|HAMAP-Rule:MF_00172}. transferase, synthase, cofactor ProteomeLM contextual percentile 0.38; strong pocket/AF2Bind evidence; essential-process annotation; high-confidence Boltz2 model; matched: transferase, synthase, cofactor /main_page_ml/ML0961 2026-05-30T13:09:52Z 512 ML2614 Q7APT2 ML2614 Conserved membrane protein 224 69.578 Strong candidate 0.8208 ProteomeLM contextual shift 0.1811963 1.0 26 1.0 469 2 0.5743 0.5625 56.25 0.08 0.8625 ProteomeLM contextual percentile 0.82; strong pocket/AF2Bind evidence /main_page_ml/ML2614 2026-05-30T13:09:52Z 513 ML1942 Q7AQ16 ML1942 Probable cholesterol dehydrogenase 376 69.561 Strong candidate 0.6548 ProteomeLM contextual shift 0.12640357 1.0 70 1.0 1233 210 0.9871 0.9144 91.44 0.125 1.0 nad, oxidoreductase, dehydrogenase, reductase ProteomeLM contextual percentile 0.65; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: nad, oxidoreductase, dehydrogenase, reductase /main_page_ml/ML1942 2026-05-30T13:09:52Z 514 ML1610 Q7AQ38 ML1610 Protein often found in Actinomycetes clustered with signal peptidase and/or RNaseHII 101 69.551 Strong candidate 0.7813 ProteomeLM contextual shift 0.16186796 1.0 16 1.0 317 28 0.8609 0.8729 87.29 0.045 0.7575 signal peptidase ProteomeLM contextual percentile 0.78; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: signal peptidase /main_page_ml/ML1610 2026-05-30T13:09:52Z 515 ML0679 Q9CCM3 ML0679 Uncharacterized protein 75 69.539 Strong candidate 0.9474 ProteomeLM contextual shift 0.5545374 1.0 12 1.0 285 120 0.9727 0.3806 38.06 0.0 0.7575 ProteomeLM contextual percentile 0.95; strong pocket/AF2Bind evidence /main_page_ml/ML0679 2026-05-30T13:09:52Z 516 ML0955 Q7AQC2 ppdK ML0955 Pyruvate, phosphate dikinase 601 69.522 Strong candidate 0.7093 ProteomeLM contextual shift 0.13968565 1.0 154 1.0 1814 22 0.7744 0.8098 80.98 0.08 1.0 kinase ProteomeLM contextual percentile 0.71; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: kinase /main_page_ml/ML0955 2026-05-30T13:09:52Z 517 ML0310 Q9ZBM2 pssA ML0310 MLCB1450.12 CDP-diacylglycerol--serine O-phosphatidyltransferase (EC 2.7.8.8) (Phosphatidylserine synthase) 300 69.515 Strong candidate 0.5764 ProteomeLM contextual shift 0.11341609 1.0 90 1.0 952 104 0.9395 0.714 71.4 0.36 1.0 2.7.8.8 transferase, synthase ProteomeLM contextual percentile 0.58; strong pocket/AF2Bind evidence; functional annotation support; matched: transferase, synthase /main_page_ml/ML0310 2026-05-30T13:09:52Z 518 ML0473 Q9CCT6 ML0473 Uncharacterized protein 90 69.514 Strong candidate 0.9085 ProteomeLM contextual shift 0.3699567 1.0 20 1.0 232 104 0.9854 0.5141 51.41 0.0 0.7575 ProteomeLM contextual percentile 0.91; strong pocket/AF2Bind evidence /main_page_ml/ML0473 2026-05-30T13:09:52Z 519 ML1419 Q7AQ57 ML1419 Possible regulatory protein 563 69.501 Strong candidate 0.7475 ProteomeLM contextual shift 0.14907719 1.0 92 1.0 1720 22 0.7294 0.7214 72.14 0.125 0.8625 transcription ProteomeLM contextual percentile 0.75; strong pocket/AF2Bind evidence; matched: transcription /main_page_ml/ML1419 2026-05-30T13:09:52Z 520 ML0110 Q9CDA3 ML0110 Arabinogalactan biosynthesis recruiting protein ML0110 123 69.481 Strong candidate 0.631 ProteomeLM contextual shift 0.12186208 1.0 24 1.0 399 60 0.9798 0.8073 80.73 0.285 0.8625 PATHWAY: Cell wall biogenesis; cell wall polysaccharide biosynthesis. {ECO:0000250|UniProtKB:P9WMS9}. cell wall ProteomeLM contextual percentile 0.63; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: cell wall /main_page_ml/ML0110 2026-05-30T13:09:52Z 521 ML2366 Q7APV5 ML2366 Membrane protein 113 69.48 Strong candidate 0.8565 ProteomeLM contextual shift 0.21575044 1.0 12 1.0 390 102 0.9275 0.5327 53.27 0.08 0.7575 ProteomeLM contextual percentile 0.86; strong pocket/AF2Bind evidence /main_page_ml/ML2366 2026-05-30T13:09:52Z 522 ML0640 Q9CCM8 ML0640 ABC1 atypical kinase-like domain-containing protein 473 69.476 Strong candidate 0.7368 ProteomeLM contextual shift 0.1460139 1.0 68 1.0 1569 300 0.9911 0.7087 70.87 0.08 1.0 kinase, transferase ProteomeLM contextual percentile 0.74; strong pocket/AF2Bind evidence; matched: kinase, transferase /main_page_ml/ML0640 2026-05-30T13:09:52Z 523 ML2664 Q7APS5 ML2664 Possible secreted protein 251 69.459 Strong candidate 0.4762 ProteomeLM contextual shift 0.10068006 1.0 38 1.0 771 36 0.8512 0.8793 87.93 0.45 1.0 PATHWAY: Cell wall biogenesis; peptidoglycan biosynthesis. {ECO:0000256|ARBA:ARBA00004752, ECO:0000256|PROSITE-ProRule:PRU01373}.; PATHWAY: Glycan biosynthesis. {ECO:0000256|ARBA:ARBA00060592}. peptidoglycan, cell wall, transferase ProteomeLM contextual percentile 0.48; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model; matched: peptidoglycan, cell wall, transferase /main_page_ml/ML2664 2026-05-30T13:09:52Z 524 ML2012 Q7AQ04 ML2012 Membrane protein 139 69.452 Strong candidate 0.7782 ProteomeLM contextual shift 0.16074921 1.0 16 1.0 447 60 0.8417 0.859 85.9 0.0 0.8625 ProteomeLM contextual percentile 0.78; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML2012 2026-05-30T13:09:52Z 525 ML0582 P55193 tal ML0582 B1496_F2_65/B1496_F1_27 MLCL536.39 Transaldolase (EC 2.2.1.2) 375 69.435 Strong candidate 0.344 ProteomeLM contextual shift 0.08518029 1.0 43 1.0 756 12 0.6315 0.9596 95.96 0.64 1.0 2.2.1.2 PATHWAY: Carbohydrate degradation; pentose phosphate pathway; D-glyceraldehyde 3-phosphate and beta-D-fructose 6-phosphate from D-ribose 5-phosphate and D-xylulose 5-phosphate (non-oxidative stage): step 2/3. ProteomeLM contextual percentile 0.34; strong pocket/AF2Bind evidence; essential-process annotation; high-confidence Boltz2 model /main_page_ml/ML0582 2026-05-30T13:09:52Z 526 ML0802 Q9CCH9 ML0802 Biotinylated protein TB7.3 homolog 71 69.422 Strong candidate 0.7957 ProteomeLM contextual shift 0.16825862 1.0 14 1.0 246 18 0.8725 0.8996 89.96 0.0 0.7575 ProteomeLM contextual percentile 0.80; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML0802 2026-05-30T13:09:52Z 527 ML0348 Q9CCV8 ML0348 Possible coenzyme F420-dependent oxidoreductase 350 69.412 Strong candidate 0.6679 ProteomeLM contextual shift 0.12891085 1.0 86 1.0 1156 212 0.9976 0.9434 94.34 0.08 1.0 enzyme, oxidoreductase, reductase ProteomeLM contextual percentile 0.67; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: enzyme, oxidoreductase, reductase /main_page_ml/ML0348 2026-05-30T13:09:52Z 528 ML1719 Q9CBR1 ML1719 Transferase 245 69.405 Strong candidate 0.7268 ProteomeLM contextual shift 0.14396699 1.0 86 1.0 761 12 0.6449 0.8967 89.67 0.0 1.0 transferase ProteomeLM contextual percentile 0.73; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: transferase /main_page_ml/ML1719 2026-05-30T13:09:52Z 529 ML2337 Q7APW1 ML2337 Membrane protein 250 69.403 Strong candidate 0.8546 ProteomeLM contextual shift 0.21298745 1.0 26 1.0 754 8 0.6812 0.5865 58.65 0.0 0.8625 ProteomeLM contextual percentile 0.85; strong pocket/AF2Bind evidence /main_page_ml/ML2337 2026-05-30T13:09:52Z 530 ML0903 Q7AQC8 ML0903 N-acetyltransferase domain-containing protein 210 69.375 Strong candidate 0.6798 ProteomeLM contextual shift 0.13071173 1.0 18 1.0 458 76 0.9857 0.8981 89.81 0.08 1.0 transferase ProteomeLM contextual percentile 0.68; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: transferase /main_page_ml/ML0903 2026-05-30T13:09:52Z 531 ML1010 Q9CCB7 ML1010 Uncharacterized protein 80 69.367 Strong candidate 0.9254 ProteomeLM contextual shift 0.4627356 1.0 12 1.0 269 58 0.9045 0.4401 44.01 0.0 0.7575 ProteomeLM contextual percentile 0.93; strong pocket/AF2Bind evidence /main_page_ml/ML1010 2026-05-30T13:09:52Z 532 ML0864 O32956 pepA ML0864 MLCB22.14 Probable cytosol aminopeptidase (EC 3.4.11.1) (Leucine aminopeptidase) (LAP) (EC 3.4.11.10) (Leucyl aminopeptidase) 524 69.345 Strong candidate 0.4367 ProteomeLM contextual shift 0.0963196 1.0 68 1.0 1614 4 0.5564 0.946 94.6 0.48 1.0 3.4.11.1; 3.4.11.10 cofactor ProteomeLM contextual percentile 0.44; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model; matched: cofactor /main_page_ml/ML0864 2026-05-30T13:09:52Z 533 ML1492 Q9CBX6 fbiC ML1492 FO synthase [Includes: 7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase (EC 4.3.1.32); 5-amino-6-(D-ribitylamino)uracil--L-tyrosine 4-hydroxyphenyl transferase (EC 2.5.1.147)] 863 69.333 Strong candidate 0.3528 ProteomeLM contextual shift 0.08649641 1.0 135 1.0 2632 86 0.8236 0.9037 90.37 0.685 0.925 2.5.1.147; 4.3.1.32 PATHWAY: Cofactor biosynthesis; coenzyme F0 biosynthesis. cofactor biosynthesis, enzyme, transferase, synthase ProteomeLM contextual percentile 0.35; strong pocket/AF2Bind evidence; essential-process annotation; high-confidence Boltz2 model; matched: cofactor biosynthesis, enzyme, transferase, synthase /main_page_ml/ML1492 2026-05-30T13:09:52Z 534 ML1976 Q9CBH4 ML1976 Uncharacterized protein 115 69.329 Strong candidate 0.938 ProteomeLM contextual shift 0.51916486 1.0 18 1.0 404 118 0.9297 0.3926 39.26 0.0 0.7575 ProteomeLM contextual percentile 0.94; strong pocket/AF2Bind evidence /main_page_ml/ML1976 2026-05-30T13:09:52Z 535 ML2666 Q9CCY7 ML2666 Uncharacterized protein 84 69.326 Strong candidate 0.9286 ProteomeLM contextual shift 0.48085725 1.0 16 1.0 277 50 0.8396 0.4251 42.51 0.0 0.7575 ProteomeLM contextual percentile 0.93; strong pocket/AF2Bind evidence /main_page_ml/ML2666 2026-05-30T13:09:52Z 536 ML0316 Q9CCW8 ML0316 TetR/AcrR-family transcriptional regulator 200 69.326 Strong candidate 0.7068 ProteomeLM contextual shift 0.13822131 1.0 36 1.0 622 4 0.5816 0.8464 84.64 0.125 0.8625 transcription ProteomeLM contextual percentile 0.71; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: transcription /main_page_ml/ML0316 2026-05-30T13:09:52Z 537 ML2330 O69519 ML2330 MLCB2407.20 Nucleoid-associated protein ML2330 116 69.324 Strong candidate 0.7801 ProteomeLM contextual shift 0.16164191 1.0 16 1.0 375 14 0.7861 0.7847 78.47 0.08 0.7575 ProteomeLM contextual percentile 0.78; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML2330 2026-05-30T13:09:52Z 538 ML0292 Q9CCX2 ML0292 Uncharacterized protein 79 69.317 Strong candidate 0.9041 ProteomeLM contextual shift 0.34456927 1.0 8 1.0 267 60 0.9666 0.5097 50.97 0.0 0.7575 ProteomeLM contextual percentile 0.90; strong pocket/AF2Bind evidence /main_page_ml/ML0292 2026-05-30T13:09:52Z 539 ML1753 Q9CBP3 ML1753 Possible transcriptional regulator 1106 69.311 Strong candidate 0.7375 ProteomeLM contextual shift 0.14610736 1.0 174 1.0 3365 14 0.6809 0.8124 81.24 0.125 0.7875 transcription ProteomeLM contextual percentile 0.74; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: transcription /main_page_ml/ML1753 2026-05-30T13:09:52Z 540 ML1788 Q7AQ24 ML1788 Uncharacterized protein 154 69.277 Strong candidate 0.9355 ProteomeLM contextual shift 0.5049087 1.0 16 1.0 489 54 0.9254 0.2911 29.11 0.0 0.8625 ProteomeLM contextual percentile 0.94; strong pocket/AF2Bind evidence /main_page_ml/ML1788 2026-05-30T13:09:52Z 541 ML2155 Q9CBE2 ML2155 Hypothetical 10.1 kDa protein 74 69.27 Strong candidate 0.9261 ProteomeLM contextual shift 0.46542278 1.0 10 1.0 254 64 0.9436 0.4283 42.83 0.0 0.7575 ProteomeLM contextual percentile 0.93; strong pocket/AF2Bind evidence /main_page_ml/ML2155 2026-05-30T13:09:52Z 542 ML2332 Q7APW4 ML2332 Polyketide cyclase 145 69.267 Strong candidate 0.7581 ProteomeLM contextual shift 0.15249096 1.0 21 1.0 476 42 0.9578 0.9107 91.07 0.0 0.8625 ProteomeLM contextual percentile 0.76; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML2332 2026-05-30T13:09:52Z 543 ML0523 Q9CCR9 nusB ML0523 Transcription antitermination protein NusB (Antitermination factor NusB) 190 69.249 Strong candidate 0.7193 ProteomeLM contextual shift 0.1418607 1.0 26 1.0 404 8 0.586 0.7948 79.48 0.125 0.8625 transcription ProteomeLM contextual percentile 0.72; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: transcription /main_page_ml/ML0523 2026-05-30T13:09:52Z 544 ML2567 Q9CD21 ML2567 Uncharacterized protein 159 69.248 Strong candidate 0.9091 ProteomeLM contextual shift 0.37675968 1.0 18 1.0 516 38 0.8481 0.3803 38.03 0.0 0.8625 ProteomeLM contextual percentile 0.91; strong pocket/AF2Bind evidence /main_page_ml/ML2567 2026-05-30T13:09:52Z 545 ML0337 Q9CCV9 ML0337 Periplasmic solute-binding proteins 302 69.247 Strong candidate 0.7306 ProteomeLM contextual shift 0.14470634 1.0 44 1.0 912 12 0.7385 0.8452 84.52 0.08 0.8625 ProteomeLM contextual percentile 0.73; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML0337 2026-05-30T13:09:52Z 546 ML0293 Q9CCX1 ML0293 Uncharacterized protein 69 69.225 Strong candidate 0.8509 ProteomeLM contextual shift 0.20973891 1.0 12 1.0 156 36 0.7649 0.527 52.7 0.08 0.7575 ProteomeLM contextual percentile 0.85; strong pocket/AF2Bind evidence /main_page_ml/ML0293 2026-05-30T13:09:52Z 547 ML1603 Q9CBT8 ML1603 Uncharacterized protein 86 69.213 Strong candidate 0.9211 ProteomeLM contextual shift 0.43315187 1.0 18 1.0 305 94 0.9691 0.4402 44.02 0.0 0.7575 ProteomeLM contextual percentile 0.92; strong pocket/AF2Bind evidence /main_page_ml/ML1603 2026-05-30T13:09:52Z 548 ML0407 Q49730 ML0407 Secretion protein EspD 216 69.204 Strong candidate 0.8584 ProteomeLM contextual shift 0.2170155 1.0 27 1.0 670 44 0.8979 0.5535 55.35 0.0 0.8625 ProteomeLM contextual percentile 0.86; strong pocket/AF2Bind evidence /main_page_ml/ML0407 2026-05-30T13:09:52Z 549 ML2350 Q9CB71 ML2350 Transport permease protein 276 69.203 Strong candidate 0.7274 ProteomeLM contextual shift 0.14409386 1.0 56 1.0 857 58 0.8494 0.8518 85.18 0.08 0.8625 ProteomeLM contextual percentile 0.73; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML2350 2026-05-30T13:09:52Z 550 ML0915 P57994 murC ML0915 UDP-N-acetylmuramate--L-alanine ligase (EC 6.3.2.8) (UDP-N-acetylmuramoyl-L-alanine synthetase) 495 69.187 Strong candidate 0.2581 ProteomeLM contextual shift 0.074231096 1.0 44 1.0 1554 138 0.9331 0.8752 87.52 0.82 1.0 6.3.2.8 PATHWAY: Cell wall biogenesis; peptidoglycan biosynthesis. {ECO:0000255|HAMAP-Rule:MF_00046}. cell division, peptidoglycan, cell wall, mur, ligase, synthetase ProteomeLM contextual percentile 0.26; strong pocket/AF2Bind evidence; essential-process annotation; high-confidence Boltz2 model; matched: cell division, peptidoglycan, cell wall, mur, ligase /main_page_ml/ML0915 2026-05-30T13:09:52Z 551 ML1226 Q49617 nadB ML1226 B1170_C1_167 L-aspartate oxidase (LASPO) (EC 1.4.3.16) (Quinolinate synthase B) 526 69.161 Strong candidate 0.2995 ProteomeLM contextual shift 0.07911326 1.0 139 1.0 1597 32 0.7459 0.9079 90.79 0.73 1.0 1.4.3.16 PATHWAY: Cofactor biosynthesis; NAD(+) biosynthesis; iminoaspartate from L-aspartate (oxidase route): step 1/1. {ECO:0000250|UniProtKB:P10902}. nad, cofactor biosynthesis, oxidoreductase, dehydrogenase, reductase ProteomeLM contextual percentile 0.30; strong pocket/AF2Bind evidence; essential-process annotation; high-confidence Boltz2 model; matched: nad, cofactor biosynthesis, oxidoreductase, dehydrogenase, reductase /main_page_ml/ML1226 2026-05-30T13:09:52Z 552 ML0025 Q9CDE1 ML0025 Uncharacterized protein 96 69.158 Strong candidate 0.9173 ProteomeLM contextual shift 0.414824 1.0 12 1.0 339 102 0.963 0.4478 44.78 0.0 0.7575 ProteomeLM contextual percentile 0.92; strong pocket/AF2Bind evidence /main_page_ml/ML0025 2026-05-30T13:09:52Z 553 ML0957 Q9CCC7 ML0957 Uncharacterized protein 124 69.12 Strong candidate 0.9098 ProteomeLM contextual shift 0.38141236 1.0 26 1.0 440 136 0.9901 0.3652 36.52 0.0 0.8625 ProteomeLM contextual percentile 0.91; strong pocket/AF2Bind evidence /main_page_ml/ML0957 2026-05-30T13:09:52Z 554 ML1407 Q9CC14 argJ ML1407 Arginine biosynthesis bifunctional protein ArgJ [Cleaved into: Arginine biosynthesis bifunctional protein ArgJ alpha chain; Arginine biosynthesis bifunctional protein ArgJ beta chain] [Includes: Glutamate N-acetyltransferase (EC 2.3.1.35) (Ornithine acetyltransferase) (OATase) (Ornithine transacetylase); Amino-acid acetyltransferase (EC 2.3.1.1) (N-acetylglutamate synthase) (AGSase)] 407 69.118 Strong candidate 0.339 ProteomeLM contextual shift 0.08448958 1.0 106 1.0 818 8 0.7577 0.9454 94.54 0.64 1.0 2.3.1.1; 2.3.1.35 PATHWAY: Amino-acid biosynthesis; L-arginine biosynthesis; L-ornithine and N-acetyl-L-glutamate from L-glutamate and N(2)-acetyl-L-ornithine (cyclic): step 1/1. {ECO:0000255|HAMAP-Rule:MF_01106}.; PATHWAY: Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 1/4. {ECO:0000255|HAMAP-Rule:MF_01106}. transferase, synthase ProteomeLM contextual percentile 0.34; strong pocket/AF2Bind evidence; essential-process annotation; high-confidence Boltz2 model; matched: transferase, synthase /main_page_ml/ML1407 2026-05-30T13:09:52Z 555 ML1069 Q9CCA8 glgC ML1069 Glucose-1-phosphate adenylyltransferase (EC 2.7.7.27) (ADP-glucose pyrophosphorylase) (ADPGlc PPase) (ADP-glucose synthase) 404 69.103 Strong candidate 0.3477 ProteomeLM contextual shift 0.0856546 1.0 124 1.0 826 36 0.6947 0.9132 91.32 0.64 1.0 2.7.7.27 PATHWAY: Capsule biogenesis; capsule polysaccharide biosynthesis. {ECO:0000305}.; PATHWAY: Glycan biosynthesis; glycogen biosynthesis. {ECO:0000255|HAMAP-Rule:MF_00624}. transferase, synthase ProteomeLM contextual percentile 0.35; strong pocket/AF2Bind evidence; essential-process annotation; high-confidence Boltz2 model; matched: transferase, synthase /main_page_ml/ML1069 2026-05-30T13:09:52Z 556 ML0205 Q7AQL9 ML0205 Membrane protein 356 69.087 Strong candidate 0.7738 ProteomeLM contextual shift 0.15907706 1.0 103 1.0 1094 52 0.9667 0.8379 83.79 0.0 0.8625 ProteomeLM contextual percentile 0.77; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML0205 2026-05-30T13:09:52Z 557 ML1470 Q9CBY9 ML1470 Conserved membrane protein 123 69.064 Strong candidate 0.797 ProteomeLM contextual shift 0.16866902 1.0 8 1.0 385 32 0.6617 0.7544 75.44 0.0 0.8625 ProteomeLM contextual percentile 0.80; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML1470 2026-05-30T13:09:52Z 558 ML0155 Q9Z5H8 sucC ML0155 MLCB373.03 Succinate--CoA ligase [ADP-forming] subunit beta (EC 6.2.1.5) (Succinyl-CoA synthetase subunit beta) (SCS-beta) 393 69.064 Strong candidate 0.364 ProteomeLM contextual shift 0.08787191 1.0 36 1.0 1190 22 0.7091 0.8522 85.22 0.64 1.0 6.2.1.5 PATHWAY: Carbohydrate metabolism; tricarboxylic acid cycle; succinate from succinyl-CoA (ligase route): step 1/1. {ECO:0000255|HAMAP-Rule:MF_00558}. ligase, synthetase, cofactor ProteomeLM contextual percentile 0.36; strong pocket/AF2Bind evidence; essential-process annotation; high-confidence Boltz2 model; matched: ligase, synthetase, cofactor /main_page_ml/ML0155 2026-05-30T13:09:52Z 559 ML0923 Q9CCD9 ML0923 Possible membrane protein 130 69.063 Strong candidate 0.8816 ProteomeLM contextual shift 0.26296997 1.0 18 1.0 474 168 0.9462 0.4583 45.83 0.0 0.8625 ProteomeLM contextual percentile 0.88; strong pocket/AF2Bind evidence /main_page_ml/ML0923 2026-05-30T13:09:52Z 560 ML1929 Q9CBI2 def ML1929 Peptide deformylase (PDF) (EC 3.5.1.88) (Polypeptide deformylase) 197 69.059 Strong candidate 0.4004 ProteomeLM contextual shift 0.092447564 1.0 44 1.0 644 106 0.9803 0.9546 95.46 0.525 1.0 3.5.1.88 translation, cofactor ProteomeLM contextual percentile 0.40; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model; matched: translation, cofactor /main_page_ml/ML1929 2026-05-30T13:09:52Z 561 ML1915 Q9CBJ3 ML1915 Uncharacterized protein 114 69.054 Strong candidate 0.8596 ProteomeLM contextual shift 0.21785505 1.0 20 1.0 401 118 0.9911 0.6392 63.92 0.0 0.7575 ProteomeLM contextual percentile 0.86; strong pocket/AF2Bind evidence /main_page_ml/ML1915 2026-05-30T13:09:52Z 562 ML2651 Q9CCZ1 ML2651 Doubtful CDS 105 69.047 Strong candidate 0.933 ProteomeLM contextual shift 0.49778077 1.0 22 1.0 358 86 0.9511 0.3819 38.19 0.0 0.7575 ProteomeLM contextual percentile 0.93; strong pocket/AF2Bind evidence /main_page_ml/ML2651 2026-05-30T13:09:52Z 563 ML1937 Q9CBI0 ML1937 Probable integral membrane protein 410 69.037 Strong candidate 0.8997 ProteomeLM contextual shift 0.31246948 1.0 50 1.0 1290 0 0.423 0.3921 39.21 0.0 0.8625 ProteomeLM contextual percentile 0.90; strong pocket/AF2Bind evidence /main_page_ml/ML1937 2026-05-30T13:09:52Z 564 ML1198 Q9X7E6 ansA ML1198 MLCB458.13c L-asparaginase (L-ASNase) (EC 3.5.1.1) (L-asparagine amidohydrolase) 310 69.031 Strong candidate 0.4286 ProteomeLM contextual shift 0.09525517 1.0 80 1.0 660 0 0.4847 0.9431 94.31 0.48 1.0 3.5.1.1 hydrolase ProteomeLM contextual percentile 0.43; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model; matched: hydrolase /main_page_ml/ML1198 2026-05-30T13:09:52Z 565 ML1717 Q9CBR2 ML1717 Doubtful CDS 97 69.001 Strong candidate 0.9505 ProteomeLM contextual shift 0.56418556 1.0 12 1.0 345 108 0.9459 0.3159 31.59 0.0 0.7575 ProteomeLM contextual percentile 0.95; strong pocket/AF2Bind evidence /main_page_ml/ML1717 2026-05-30T13:09:52Z 566 ML0977 O05560 ftsK ML0977 MLCB33.09c DNA translocase FtsK 840 68.976 Strong candidate 0.6754 ProteomeLM contextual shift 0.13006271 1.0 114 1.0 2718 0 0.3054 0.666 66.6 0.29 0.7875 cell division, fts ProteomeLM contextual percentile 0.68; strong pocket/AF2Bind evidence; matched: cell division, fts /main_page_ml/ML0977 2026-05-30T13:09:52Z 567 ML1805 Q9CBM2 cpfC hemH hemZ ML1805 Coproporphyrin III ferrochelatase (EC 4.99.1.9) 336 68.972 Strong candidate 0.3409 ProteomeLM contextual shift 0.084704146 1.0 38 1.0 1115 214 0.9987 0.9242 92.42 0.64 1.0 4.99.1.9 PATHWAY: Porphyrin-containing compound metabolism; protoheme biosynthesis. {ECO:0000255|HAMAP-Rule:MF_00323}. ProteomeLM contextual percentile 0.34; strong pocket/AF2Bind evidence; essential-process annotation; high-confidence Boltz2 model /main_page_ml/ML1805 2026-05-30T13:09:52Z 568 ML0405 Q49722 ML0405 ESX-1 secretion-associated protein EspA/EspE-like domain-containing protein 394 68.957 Strong candidate 0.8728 ProteomeLM contextual shift 0.2448653 1.0 50 1.0 804 32 0.8375 0.4784 47.84 0.0 0.8625 ProteomeLM contextual percentile 0.87; strong pocket/AF2Bind evidence /main_page_ml/ML0405 2026-05-30T13:09:52Z 569 ML2081 Q7APZ2 pgsA2 ML2081 CDP-diacylglycerol-glycerol-3-phosphate 206 68.941 Strong candidate 0.5808 ProteomeLM contextual shift 0.11444735 1.0 54 1.0 667 98 0.9861 0.7912 79.12 0.285 1.0 PATHWAY: Lipid metabolism; phospholipid metabolism. {ECO:0000256|ARBA:ARBA00005074}. lipid metabolism, transferase ProteomeLM contextual percentile 0.58; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: lipid metabolism, transferase /main_page_ml/ML2081 2026-05-30T13:09:52Z 570 ML0067 Q9CDD1 hns ML0067 Histone-like protein 121 68.939 Strong candidate 0.8784 ProteomeLM contextual shift 0.2531675 1.0 14 1.0 261 38 0.9242 0.4568 45.68 0.0 0.8625 ProteomeLM contextual percentile 0.88; strong pocket/AF2Bind evidence /main_page_ml/ML0067 2026-05-30T13:09:52Z 571 ML0539 Q9CCQ9 PPE ML0539 PPE-family protein 538 68.9 Strong candidate 0.8183 ProteomeLM contextual shift 0.17824419 1.0 82 1.0 1089 26 0.8307 0.5035 50.35 0.08 0.8625 ProteomeLM contextual percentile 0.82; strong pocket/AF2Bind evidence /main_page_ml/ML0539 2026-05-30T13:09:52Z 572 ML2692 17 68.891 Strong candidate 0.8947 ProteomeLM contextual shift 0.29210156 1.0 162 1.0 1167 120 0.9406 0.5 0.0 0.7575 ProteomeLM contextual percentile 0.89; strong pocket/AF2Bind evidence /main_page_ml/ML2692 2026-05-30T13:09:52Z 573 ML1996 Q7AQ07 nrp ML1996 Probable peptide synthase 1401 68.889 Strong candidate 0.713 ProteomeLM contextual shift 0.1404387 1.0 227 1.0 1421 0 0.2716 0.8083 80.83 0.125 0.835 ribosomal, ligase, synthase, cofactor ProteomeLM contextual percentile 0.71; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: ribosomal, ligase, synthase, cofactor /main_page_ml/ML1996 2026-05-30T13:09:52Z 574 ML1495 Q9CBX4 mshB ML1495 1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside deacetylase (GlcNAc-Ins deacetylase) (EC 3.5.1.103) (N-acetyl-1-D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside deacetylase) 308 68.889 Strong candidate 0.4292 ProteomeLM contextual shift 0.09531397 1.0 50 1.0 974 100 0.9675 0.9267 92.67 0.48 1.0 3.5.1.103 cofactor ProteomeLM contextual percentile 0.43; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model; matched: cofactor /main_page_ml/ML1495 2026-05-30T13:09:52Z 575 ML1755 Q9CBP2 sdaA ML1755 L-serine dehydratase (EC 4.3.1.17) 458 68.884 Strong candidate 0.4142 ProteomeLM contextual shift 0.09373715 1.0 114 1.0 1396 4 0.6327 0.8988 89.88 0.52 1.0 4.3.1.17 PATHWAY: Carbohydrate biosynthesis; gluconeogenesis. {ECO:0000256|ARBA:ARBA00004742}. lyase, cofactor ProteomeLM contextual percentile 0.41; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model; matched: lyase, cofactor /main_page_ml/ML1755 2026-05-30T13:09:52Z 576 ML2527 Q9CD37 ML2527 Conserved membrane protein 339 68.879 Strong candidate 0.7437 ProteomeLM contextual shift 0.14749438 1.0 36 1.0 1021 8 0.6688 0.7623 76.23 0.08 0.8625 ProteomeLM contextual percentile 0.74; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML2527 2026-05-30T13:09:52Z 577 ML2608 O06069 ilvD ML2608 MLCL622.06c Dihydroxy-acid dehydratase (DAD) (EC 4.2.1.9) 564 68.878 Strong candidate 0.3289 ProteomeLM contextual shift 0.08219342 1.0 321 1.0 1732 80 0.8727 0.9565 95.65 0.64 1.0 4.2.1.9 PATHWAY: Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 3/4. {ECO:0000255|HAMAP-Rule:MF_00012}.; PATHWAY: Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 3/4. {ECO:0000255|HAMAP-Rule:MF_00012}. cofactor ProteomeLM contextual percentile 0.33; strong pocket/AF2Bind evidence; essential-process annotation; high-confidence Boltz2 model; matched: cofactor /main_page_ml/ML2608 2026-05-30T13:09:52Z 578 ML2129 17 68.869 Strong candidate 0.8941 ProteomeLM contextual shift 0.29210156 1.0 10 1.0 170 22 0.8172 0.5 0.0 0.7575 ProteomeLM contextual percentile 0.89; strong pocket/AF2Bind evidence /main_page_ml/ML2129 2026-05-30T13:09:52Z 579 ML0453 Q7AQJ0 ML0453 Phosphatidylinositol mannoside acyltransferase 320 68.851 Strong candidate 0.6698 ProteomeLM contextual shift 0.12937944 1.0 56 1.0 718 156 0.9959 0.8808 88.08 0.08 1.0 transferase ProteomeLM contextual percentile 0.67; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: transferase /main_page_ml/ML0453 2026-05-30T13:09:52Z 580 ML1183 17 68.847 Strong candidate 0.8935 ProteomeLM contextual shift 0.29210156 1.0 10 1.0 219 2 0.6444 0.5 0.0 0.7575 ProteomeLM contextual percentile 0.89; strong pocket/AF2Bind evidence /main_page_ml/ML1183 2026-05-30T13:09:52Z 581 ML1181 17 68.825 Strong candidate 0.8929 ProteomeLM contextual shift 0.2921015 1.0 12 1.0 321 42 0.8592 0.5 0.0 0.7575 ProteomeLM contextual percentile 0.89; strong pocket/AF2Bind evidence /main_page_ml/ML1181 2026-05-30T13:09:52Z 582 ML0131 Q9CD85 ML0131 Phthiodiolone/phenolphthiodiolone dimycocerosates ketoreductase (EC 1.2.-.-) 382 68.813 Strong candidate 0.5645 ProteomeLM contextual shift 0.11106807 1.0 62 1.0 1284 276 0.9983 0.9254 92.54 0.24 1.0 1.2.-.- oxidoreductase, reductase ProteomeLM contextual percentile 0.56; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: oxidoreductase, reductase /main_page_ml/ML0131 2026-05-30T13:09:52Z 583 ML1991 Q9CBG5 PPE ML1991 PPE-family protein 468 68.806 Strong candidate 0.8352 ProteomeLM contextual shift 0.19365512 1.0 62 1.0 941 10 0.8499 0.4349 43.49 0.08 0.8625 ProteomeLM contextual percentile 0.84; strong pocket/AF2Bind evidence /main_page_ml/ML1991 2026-05-30T13:09:52Z 584 ML1180 17 68.803 Strong candidate 0.8922 ProteomeLM contextual shift 0.29210135 1.0 10 1.0 303 36 0.9379 0.5 0.0 0.7575 ProteomeLM contextual percentile 0.89; strong pocket/AF2Bind evidence /main_page_ml/ML1180 2026-05-30T13:09:52Z 585 ML0959 Q9CCC5 ML0959 Uncharacterized protein 117 68.8 Strong candidate 0.9273 ProteomeLM contextual shift 0.46650723 1.0 20 1.0 393 84 0.9899 0.3769 37.69 0.0 0.7575 ProteomeLM contextual percentile 0.93; strong pocket/AF2Bind evidence /main_page_ml/ML0959 2026-05-30T13:09:52Z 586 ML0664 Q9CCM5 ML0664 Uncharacterized protein 87 68.795 Strong candidate 0.8753 ProteomeLM contextual shift 0.2486664 1.0 14 1.0 288 14 0.7907 0.5584 55.84 0.0 0.7575 ProteomeLM contextual percentile 0.88; strong pocket/AF2Bind evidence /main_page_ml/ML0664 2026-05-30T13:09:52Z 587 ML2630 O06091 ML2630 MLCL622.28c Uncharacterized protein ML2630 123 68.793 Strong candidate 0.8991 ProteomeLM contextual shift 0.3110854 1.0 10 1.0 403 68 0.8332 0.3699 36.99 0.0 0.8625 ProteomeLM contextual percentile 0.90; strong pocket/AF2Bind evidence /main_page_ml/ML2630 2026-05-30T13:09:52Z 588 ML1945 Q7AQ15 ML1945 Secreted protein 257 68.785 Strong candidate 0.8158 ProteomeLM contextual shift 0.1764099 1.0 42 1.0 530 32 0.9164 0.6607 66.07 0.0 0.8625 ProteomeLM contextual percentile 0.82; strong pocket/AF2Bind evidence /main_page_ml/ML1945 2026-05-30T13:09:52Z 589 ML2134 O33064 fprB ML2134 MLCB57.39 Probable ferredoxin/ferredoxin--NADP reductase (FNR) (EC 1.18.1.2) 555 68.784 Strong candidate 0.4035 ProteomeLM contextual shift 0.0928675 1.0 118 1.0 1735 140 0.9499 0.9161 91.61 0.525 1.0 1.18.1.2 nad, reductase, cofactor ProteomeLM contextual percentile 0.40; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model; matched: nad, reductase, cofactor /main_page_ml/ML2134 2026-05-30T13:09:52Z 590 ML1420 Q7AQ56 ML1420 Uncharacterized protein 117 68.773 Strong candidate 0.9123 ProteomeLM contextual shift 0.3915655 1.0 26 1.0 413 124 0.9444 0.4268 42.68 0.0 0.7575 ProteomeLM contextual percentile 0.91; strong pocket/AF2Bind evidence /main_page_ml/ML1420 2026-05-30T13:09:52Z 591 ML0024 Q9CDE2 ML0024 Uncharacterized protein 83 68.755 Strong candidate 0.9073 ProteomeLM contextual shift 0.36423 1.0 10 1.0 294 90 0.9774 0.4426 44.26 0.0 0.7575 ProteomeLM contextual percentile 0.91; strong pocket/AF2Bind evidence /main_page_ml/ML0024 2026-05-30T13:09:52Z 592 ML0589 Q7AQH9 ML0589 Membrane protein 265 68.746 Strong candidate 0.7174 ProteomeLM contextual shift 0.141289 1.0 56 1.0 811 32 0.7476 0.8412 84.12 0.08 0.8625 ProteomeLM contextual percentile 0.72; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML0589 2026-05-30T13:09:52Z 593 ML0070 Q9CDC8 ML0070 Uncharacterized protein 87 68.738 Strong candidate 0.9192 ProteomeLM contextual shift 0.4209241 1.0 10 1.0 311 100 0.9755 0.3992 39.92 0.0 0.7575 ProteomeLM contextual percentile 0.92; strong pocket/AF2Bind evidence /main_page_ml/ML0070 2026-05-30T13:09:52Z 594 ML0486 Q49647 yajC ML0486 B1177_C3_235 MLCB1259.04 Sec translocon accessory complex subunit YajC 114 68.721 Strong candidate 0.7876 ProteomeLM contextual shift 0.16399032 1.0 8 1.0 374 24 0.8684 0.698 69.8 0.08 0.7575 ProteomeLM contextual percentile 0.79; strong pocket/AF2Bind evidence /main_page_ml/ML0486 2026-05-30T13:09:52Z 595 ML0218 Q7AQL5 ML0218 Uncharacterized protein 128 68.714 Strong candidate 0.9066 ProteomeLM contextual shift 0.36183262 1.0 16 1.0 468 168 0.9524 0.3356 33.56 0.0 0.8625 ProteomeLM contextual percentile 0.91; strong pocket/AF2Bind evidence /main_page_ml/ML0218 2026-05-30T13:09:52Z 596 ML0467 Q49642 ML0467 B1177_C2_172/B1177_C1_140 MLCL581.27 Uncharacterized membrane protein ML0467 214 68.711 Strong candidate 0.7243 ProteomeLM contextual shift 0.14354576 1.0 40 1.0 703 122 0.9668 0.8135 81.35 0.08 0.8625 ProteomeLM contextual percentile 0.72; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML0467 2026-05-30T13:09:52Z 597 ML1727 Q9CBQ6 ML1727 phosphoserine phosphatase (EC 3.1.3.3) (O-phosphoserine phosphohydrolase) 411 68.699 Strong candidate 0.3427 ProteomeLM contextual shift 0.084872484 1.0 112 1.0 1271 76 0.9737 0.8904 89.04 0.64 1.0 3.1.3.3 PATHWAY: Amino-acid biosynthesis; L-serine biosynthesis; L-serine from 3-phospho-D-glycerate: step 3/3. {ECO:0000256|ARBA:ARBA00005135}. hydrolase, cofactor ProteomeLM contextual percentile 0.34; strong pocket/AF2Bind evidence; essential-process annotation; high-confidence Boltz2 model; matched: hydrolase, cofactor /main_page_ml/ML1727 2026-05-30T13:09:52Z 598 ML0988 P37859 recX ML0988 u2235b Regulatory protein RecX 171 68.696 Strong candidate 0.7049 ProteomeLM contextual shift 0.13783884 1.0 8 1.0 573 0 0.3973 0.88 88.0 0.08 0.8625 ProteomeLM contextual percentile 0.70; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML0988 2026-05-30T13:09:52Z 599 ML1660 O69468 ML1660 MLCB1243.14 Uncharacterized protein ML1660 217 68.694 Strong candidate 0.8064 ProteomeLM contextual shift 0.17138954 1.0 20 1.0 663 24 0.7832 0.6845 68.45 0.0 0.8625 ProteomeLM contextual percentile 0.81; strong pocket/AF2Bind evidence /main_page_ml/ML1660 2026-05-30T13:09:52Z 600 ML1294 Q9CC44 ML1294 Dihydroorotate dehydrogenase 84 68.688 Strong candidate 0.765 ProteomeLM contextual shift 0.15629171 1.0 14 1.0 272 40 0.8527 0.7961 79.61 0.0 0.895 dehydrogenase ProteomeLM contextual percentile 0.77; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: dehydrogenase /main_page_ml/ML1294 2026-05-30T13:09:52Z 601 ML1684 O33124 leuD ML1684 MLCB637.33 3-isopropylmalate dehydratase small subunit (EC 4.2.1.33) (Alpha-IPM isomerase) (IPMI) (Isopropylmalate isomerase) 198 68.686 Strong candidate 0.4091 ProteomeLM contextual shift 0.093136124 1.0 13 1.0 597 6 0.6107 0.8966 89.66 0.52 1.0 4.2.1.33 PATHWAY: Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 2/4. isomerase ProteomeLM contextual percentile 0.41; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model; matched: isomerase /main_page_ml/ML1684 2026-05-30T13:09:52Z 602 ML1233 Q49630 ML1233 Conserved membrane protein 230 68.684 Strong candidate 0.7851 ProteomeLM contextual shift 0.16286986 1.0 48 1.0 728 76 0.959 0.7581 75.81 0.0 0.8625 ProteomeLM contextual percentile 0.79; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML1233 2026-05-30T13:09:52Z 603 ML0568 Q9CCN7 ML0568 Uncharacterized protein 197 68.683 Strong candidate 0.9035 ProteomeLM contextual shift 0.34368885 1.0 28 1.0 741 300 0.9927 0.3435 34.35 0.0 0.8625 ProteomeLM contextual percentile 0.90; strong pocket/AF2Bind evidence /main_page_ml/ML0568 2026-05-30T13:09:52Z 604 ML1171 P53426 ML1171 B1549_C3_240 Uncharacterized protein ML1171 251 68.674 Strong candidate 0.7469 ProteomeLM contextual shift 0.14887382 1.0 51 1.0 737 46 0.9193 0.7309 73.09 0.08 0.8625 ProteomeLM contextual percentile 0.75; strong pocket/AF2Bind evidence /main_page_ml/ML1171 2026-05-30T13:09:52Z 605 ML0311 Q9CCW9 psd ML0311 MLCB1450.11 Phosphatidylserine decarboxylase proenzyme (EC 4.1.1.65) [Cleaved into: Phosphatidylserine decarboxylase alpha chain; Phosphatidylserine decarboxylase beta chain] 243 68.664 Strong candidate 0.3221 ProteomeLM contextual shift 0.08137037 1.0 28 1.0 526 0 0.4868 0.8692 86.92 0.685 1.0 4.1.1.65 PATHWAY: Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from CDP-diacylglycerol: step 2/2. {ECO:0000255|HAMAP-Rule:MF_00664}. lipid metabolism, enzyme, cofactor ProteomeLM contextual percentile 0.32; strong pocket/AF2Bind evidence; essential-process annotation; high-confidence Boltz2 model; matched: lipid metabolism, enzyme, cofactor /main_page_ml/ML0311 2026-05-30T13:09:52Z 606 ML1124 Q9CC79 ML1124 Probable binding-protein dependent transport protein 325 68.66 Strong candidate 0.7112 ProteomeLM contextual shift 0.14003538 1.0 80 1.0 982 14 0.8048 0.8545 85.45 0.08 0.8625 ProteomeLM contextual percentile 0.71; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML1124 2026-05-30T13:09:52Z 607 ML1056 Q49946 ML1056 u1756d; ML1180 MLCB1701.06c Putative ESAT-6-like protein X 95 68.603 Strong candidate 0.7888 ProteomeLM contextual shift 0.16443573 1.0 14 1.0 304 38 0.9379 0.8418 84.18 0.0 0.7575 ProteomeLM contextual percentile 0.79; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML1056 2026-05-30T13:09:52Z 608 ML2176 Q9CBD2 ML2176 Uncharacterized protein 85 68.602 Strong candidate 0.8866 ProteomeLM contextual shift 0.27717385 1.0 12 1.0 184 28 0.8666 0.4996 49.96 0.0 0.7575 ProteomeLM contextual percentile 0.89; strong pocket/AF2Bind evidence /main_page_ml/ML2176 2026-05-30T13:09:52Z 609 ML1729 Q9CBQ4 fecB ML1729 FeIII-dicitrate transporter lipoprotein 364 68.595 Strong candidate 0.7055 ProteomeLM contextual shift 0.13786168 1.0 74 1.0 1107 30 0.8563 0.8677 86.77 0.08 0.8625 ProteomeLM contextual percentile 0.71; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML1729 2026-05-30T13:09:52Z 610 ML0431 Q9CCU3 ML0431 Membrane protein 259 68.582 Strong candidate 0.817 ProteomeLM contextual shift 0.1773447 1.0 32 1.0 800 6 0.5613 0.4761 47.61 0.08 0.8625 ProteomeLM contextual percentile 0.82; strong pocket/AF2Bind evidence /main_page_ml/ML0431 2026-05-30T13:09:52Z 611 ML2260 Q50173 pit pitA ML2260 Probable low-affinity inorganic phosphate transporter 414 68.568 Strong candidate 0.6429 ProteomeLM contextual shift 0.1236046 1.0 132 1.0 1248 12 0.72 0.8443 84.43 0.2 0.8625 ProteomeLM contextual percentile 0.64; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML2260 2026-05-30T13:09:52Z 612 ML0125 Q9CD91 ML0125 Glycosyl transferase 438 68.558 Strong candidate 0.6654 ProteomeLM contextual shift 0.12844265 1.0 50 1.0 936 120 0.9757 0.8669 86.69 0.08 1.0 transferase ProteomeLM contextual percentile 0.67; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: transferase /main_page_ml/ML0125 2026-05-30T13:09:52Z 613 ML2379 Q9CB69 ML2379 Uncharacterized protein 109 68.55 Strong candidate 0.7926 ProteomeLM contextual shift 0.1669717 1.0 16 1.0 258 80 0.9689 0.8234 82.34 0.0 0.7575 ProteomeLM contextual percentile 0.79; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML2379 2026-05-30T13:09:52Z 614 ML1956 Q9X797 rplQ ML1956 MLCB1222.26c Large ribosomal subunit protein bL17 (50S ribosomal protein L17) 170 68.543 Strong candidate 0.6786 ProteomeLM contextual shift 0.13062406 1.0 14 1.0 536 12 0.8269 0.6868 68.68 0.215 0.8625 translation, ribosome, ribosomal ProteomeLM contextual percentile 0.68; strong pocket/AF2Bind evidence; matched: translation, ribosome, ribosomal /main_page_ml/ML1956 2026-05-30T13:09:52Z 615 ML1711 O33096 etfA fixB ML1711 MLCB637.04 Electron transfer flavoprotein subunit alpha (Alpha-ETF) (Electron transfer flavoprotein large subunit) (ETFLS) 318 68.54 Strong candidate 0.5971 ProteomeLM contextual shift 0.11684371 1.0 66 1.0 971 34 0.8945 0.8641 86.41 0.2 1.0 dehydrogenase, cofactor ProteomeLM contextual percentile 0.60; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: dehydrogenase, cofactor /main_page_ml/ML1711 2026-05-30T13:09:52Z 616 ML2453 Q9CB43 ML2453 Uncharacterized protein ML2453 87 68.538 Strong candidate 0.7212 ProteomeLM contextual shift 0.14278394 1.0 8 1.0 192 4 0.6313 0.9122 91.22 0.08 0.7575 ProteomeLM contextual percentile 0.72; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML2453 2026-05-30T13:09:52Z 617 ML0592 Q7AQH6 ML0592 DNA-binding protein 254 68.529 Strong candidate 0.7494 ProteomeLM contextual shift 0.149522 1.0 44 1.0 544 72 0.9469 0.7076 70.76 0.08 0.8625 ProteomeLM contextual percentile 0.75; strong pocket/AF2Bind evidence /main_page_ml/ML0592 2026-05-30T13:09:52Z 618 ML0141 Q9CD77 ML0141 Uncharacterized protein 84 68.517 Strong candidate 0.9305 ProteomeLM contextual shift 0.49050546 1.0 10 1.0 318 132 0.9641 0.3376 33.76 0.0 0.7575 ProteomeLM contextual percentile 0.93; strong pocket/AF2Bind evidence /main_page_ml/ML0141 2026-05-30T13:09:52Z 619 ML0354 Q49865 ilvX ML0354 acetolactate synthase (EC 2.2.1.6) 515 68.506 Strong candidate 0.391 ProteomeLM contextual shift 0.091719426 1.0 128 1.0 1593 96 0.8852 0.9422 94.22 0.52 1.0 2.2.1.6 PATHWAY: Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 1/4. {ECO:0000256|ARBA:ARBA00004974}.; PATHWAY: Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 1/4. {ECO:0000256|ARBA:ARBA00005025}. enzyme, synthase ProteomeLM contextual percentile 0.39; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model; matched: enzyme, synthase /main_page_ml/ML0354 2026-05-30T13:09:52Z 620 ML1057 Q7AQA0 ML1057 Uncharacterized protein 117 68.505 Strong candidate 0.9361 ProteomeLM contextual shift 0.50859785 1.0 10 1.0 298 128 0.997 0.3167 31.67 0.0 0.7575 ProteomeLM contextual percentile 0.94; strong pocket/AF2Bind evidence /main_page_ml/ML1057 2026-05-30T13:09:52Z 621 ML1691 O33117 leuB ML1691 MLCB637.26 3-isopropylmalate dehydrogenase (EC 1.1.1.85) (3-IPM-DH) (Beta-IPM dehydrogenase) (IMDH) 336 68.46 Strong candidate 0.2939 ProteomeLM contextual shift 0.0786726 1.0 116 1.0 1097 178 0.9729 0.9475 94.75 0.685 1.0 1.1.1.85 PATHWAY: Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 3/4. nad, dehydrogenase, cofactor ProteomeLM contextual percentile 0.29; strong pocket/AF2Bind evidence; essential-process annotation; high-confidence Boltz2 model; matched: nad, dehydrogenase, cofactor /main_page_ml/ML1691 2026-05-30T13:09:52Z 622 ML0317 P09239 groEL2 groL2 ML0317 MLCB1450.05c Chaperonin GroEL 2 (EC 5.6.1.7) (60 kDa chaperonin 2) (65 kDa antigen) (Chaperonin-60 2) (Cpn60 2) 541 68.438 Strong candidate 0.416 ProteomeLM contextual shift 0.09381282 1.0 112 1.0 1646 6 0.5927 0.8377 83.77 0.525 1.0 5.6.1.7 cell wall, isomerase ProteomeLM contextual percentile 0.42; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model; matched: cell wall, isomerase /main_page_ml/ML0317 2026-05-30T13:09:52Z 623 ML0007 O32870 ML0007 MLB1770.07 Uncharacterized protein ML0007 303 68.434 Strong candidate 0.8496 ProteomeLM contextual shift 0.20638715 1.0 22 1.0 626 40 0.8903 0.3472 34.72 0.08 0.8625 ProteomeLM contextual percentile 0.85; strong pocket/AF2Bind evidence /main_page_ml/ML0007 2026-05-30T13:09:52Z 624 ML0707 P46862 punA deoD ML0707 L308_F2_56 Purine nucleoside phosphorylase (PNP) (Pu-NPase) (EC 2.4.2.1) (Inosine phosphorylase) (Inosine-guanosine phosphorylase) 268 68.423 Strong candidate 0.3308 ProteomeLM contextual shift 0.08260607 1.0 74 1.0 872 136 0.9932 0.9044 90.44 0.64 1.0 2.4.2.1 PATHWAY: Purine metabolism; purine nucleoside salvage. ProteomeLM contextual percentile 0.33; strong pocket/AF2Bind evidence; essential-process annotation; high-confidence Boltz2 model /main_page_ml/ML0707 2026-05-30T13:09:52Z 625 ML0855 O32965 ML0855 MLCB22.26c Uncharacterized zinc protease ML0855 (EC 3.4.24.-) 445 68.384 Strong candidate 0.4806 ProteomeLM contextual shift 0.1009194 1.0 56 1.0 1365 186 0.9584 0.9363 93.63 0.36 1.0 3.4.24.- protease, cofactor ProteomeLM contextual percentile 0.48; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model; matched: protease, cofactor /main_page_ml/ML0855 2026-05-30T13:09:52Z 626 ML0736 P46702 purE ML0736 B1308_F3_98 N5-carboxyaminoimidazole ribonucleotide mutase (N5-CAIR mutase) (EC 5.4.99.18) (5-(carboxyamino)imidazole ribonucleotide mutase) 171 68.381 Strong candidate 0.3246 ProteomeLM contextual shift 0.08157334 1.0 127 1.0 346 8 0.7011 0.9221 92.21 0.64 1.0 5.4.99.18 PATHWAY: Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate from 5-amino-1-(5-phospho-D-ribosyl)imidazole (N5-CAIR route): step 2/2. {ECO:0000255|HAMAP-Rule:MF_01929}. ProteomeLM contextual percentile 0.32; strong pocket/AF2Bind evidence; essential-process annotation; high-confidence Boltz2 model /main_page_ml/ML0736 2026-05-30T13:09:52Z 627 ML1216 P45488 bioA ML1216 B1170_C2_195 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase (EC 2.6.1.62) (7,8-diamino-pelargonic acid aminotransferase) (DAPA AT) (DAPA aminotransferase) (7,8-diaminononanoate synthase) (DANS) (Diaminopelargonic acid synthase) 436 68.372 Strong candidate 0.2901 ProteomeLM contextual shift 0.07826723 1.0 121 1.0 1394 172 0.9722 0.9518 95.18 0.685 1.0 2.6.1.62 PATHWAY: Cofactor biosynthesis; biotin biosynthesis; 7,8-diaminononanoate from 8-amino-7-oxononanoate (SAM route): step 1/1. {ECO:0000255|HAMAP-Rule:MF_00834}. cofactor biosynthesis, transferase, synthase, cofactor ProteomeLM contextual percentile 0.29; strong pocket/AF2Bind evidence; essential-process annotation; high-confidence Boltz2 model; matched: cofactor biosynthesis, transferase, synthase, cofactor /main_page_ml/ML1216 2026-05-30T13:09:52Z 628 ML2450 Q9CB46 ML2450 Possible secreted protein 245 68.343 Strong candidate 0.7607 ProteomeLM contextual shift 0.15381601 1.0 28 1.0 782 94 0.9468 0.8095 80.95 0.0 0.8625 ProteomeLM contextual percentile 0.76; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML2450 2026-05-30T13:09:52Z 629 ML0398 Q49738 ML0398 D-ribose-binding protein 345 68.326 Strong candidate 0.6974 ProteomeLM contextual shift 0.13604596 1.0 40 1.0 1056 42 0.9139 0.8693 86.93 0.08 0.8625 ProteomeLM contextual percentile 0.70; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML0398 2026-05-30T13:09:52Z 630 ML1004 Q7AQB5 ML1004 Possible conserved membrane protein 164 68.294 Strong candidate 0.8333 ProteomeLM contextual shift 0.19064069 1.0 10 1.0 568 152 0.9429 0.5502 55.02 0.0 0.8625 ProteomeLM contextual percentile 0.83; strong pocket/AF2Bind evidence /main_page_ml/ML1004 2026-05-30T13:09:52Z 631 ML0630 Q49767 ML0630 Cytidine deaminase 108 68.29 Strong candidate 0.8239 ProteomeLM contextual shift 0.18325682 1.0 10 1.0 364 80 0.8274 0.6878 68.78 0.0 0.7575 ProteomeLM contextual percentile 0.82; strong pocket/AF2Bind evidence /main_page_ml/ML0630 2026-05-30T13:09:52Z 632 ML1949 Q9CBH8 ML1949 Uncharacterized protein 119 68.266 Strong candidate 0.9004 ProteomeLM contextual shift 0.31299907 1.0 16 1.0 412 110 0.97 0.4178 41.78 0.0 0.7575 ProteomeLM contextual percentile 0.90; strong pocket/AF2Bind evidence /main_page_ml/ML1949 2026-05-30T13:09:52Z 633 ML1016 Q7AQB3 ML1016 DUF3039 domain-containing protein 107 68.255 Strong candidate 0.8365 ProteomeLM contextual shift 0.19432104 1.0 20 1.0 348 54 0.9747 0.6403 64.03 0.0 0.7575 ProteomeLM contextual percentile 0.84; strong pocket/AF2Bind evidence /main_page_ml/ML1016 2026-05-30T13:09:52Z 634 ML0896 Q7AQD4 aroG ML0896 Phospho-2-dehydro-3-deoxyheptonate aldolase (EC 2.5.1.54) 462 68.24 Strong candidate 0.3208 ProteomeLM contextual shift 0.08126783 1.0 219 1.0 1392 12 0.5833 0.9212 92.12 0.64 1.0 2.5.1.54 PATHWAY: Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 1/7. {ECO:0000256|ARBA:ARBA00004688, ECO:0000256|RuleBase:RU363071}. enzyme, synthase, cofactor ProteomeLM contextual percentile 0.32; strong pocket/AF2Bind evidence; essential-process annotation; high-confidence Boltz2 model; matched: enzyme, synthase, cofactor /main_page_ml/ML0896 2026-05-30T13:09:52Z 635 ML0810 Q9CCH4 ML0810 Membrane protein 407 68.238 Strong candidate 0.7299 ProteomeLM contextual shift 0.14461692 1.0 56 1.0 1278 114 0.8995 0.9065 90.65 0.0 0.8625 ProteomeLM contextual percentile 0.73; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML0810 2026-05-30T13:09:52Z 636 ML1453 Q9CBZ9 rsfS ML1453 Ribosomal silencing factor RsfS 129 68.238 Strong candidate 0.6165 ProteomeLM contextual shift 0.11935961 1.0 30 1.0 414 54 0.8512 0.8734 87.34 0.215 0.8625 translation, ribosome, ribosomal ProteomeLM contextual percentile 0.62; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: translation, ribosome, ribosomal /main_page_ml/ML1453 2026-05-30T13:09:52Z 637 ML0126 Q9CD90 ML0126 Biotin carboxyl carrier protein 273 68.236 Strong candidate 0.7419 ProteomeLM contextual shift 0.14722309 1.0 38 1.0 857 76 0.9209 0.8646 86.46 0.0 0.8625 ProteomeLM contextual percentile 0.74; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML0126 2026-05-30T13:09:52Z 638 ML1296 Q9CC43 ML1296 Uncharacterized protein 111 68.234 Strong candidate 0.8177 ProteomeLM contextual shift 0.17797741 1.0 10 1.0 361 56 0.8373 0.704 70.4 0.0 0.7575 ProteomeLM contextual percentile 0.82; strong pocket/AF2Bind evidence /main_page_ml/ML1296 2026-05-30T13:09:52Z 639 ML1472 Q9CBY7 valS ML1472 Valine--tRNA ligase (EC 6.1.1.9) (Valyl-tRNA synthetase) (ValRS) 886 68.229 Strong candidate 0.3885 ProteomeLM contextual shift 0.091165446 1.0 100 1.0 2718 0 0.273 0.8983 89.83 0.57 0.925 6.1.1.9 aminoacyl-trna, trna ligase, ligase, synthetase ProteomeLM contextual percentile 0.39; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model; matched: aminoacyl-trna, trna ligase, ligase, synthetase /main_page_ml/ML1472 2026-05-30T13:09:52Z 640 ML2195 Q7APX9 ML2195 Probable exported protein 283 68.21 Strong candidate 0.7425 ProteomeLM contextual shift 0.14743467 1.0 14 1.0 909 0 0.3295 0.8598 85.98 0.0 0.8625 ProteomeLM contextual percentile 0.74; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML2195 2026-05-30T13:09:52Z 641 ML0395 P46810 guaA ML0395 B1620_C2_205 GMP synthase [glutamine-hydrolyzing] (EC 6.3.5.2) (GMP synthetase) (Glutamine amidotransferase) 529 68.209 Strong candidate 0.3434 ProteomeLM contextual shift 0.084958166 1.0 129 1.0 1661 148 0.9912 0.8391 83.91 0.64 1.0 6.3.5.2 PATHWAY: Purine metabolism; GMP biosynthesis; GMP from XMP (L-Gln route): step 1/1. transferase, synthetase, synthase ProteomeLM contextual percentile 0.34; strong pocket/AF2Bind evidence; essential-process annotation; high-confidence Boltz2 model; matched: transferase, synthetase, synthase /main_page_ml/ML0395 2026-05-30T13:09:52Z 642 ML2046 Q9CBF2 lldD2 ML2046 Putative L-lactate dehydrogenase 414 68.167 Strong candidate 0.5175 ProteomeLM contextual shift 0.10449388 1.0 134 1.0 858 60 0.8882 0.8653 86.53 0.32 1.0 oxidoreductase, dehydrogenase, reductase ProteomeLM contextual percentile 0.52; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: oxidoreductase, dehydrogenase, reductase /main_page_ml/ML2046 2026-05-30T13:09:52Z 643 ML1498 Q9CBX2 bipA ML1498 Large ribosomal subunit assembly factor BipA (EC 3.6.5.-) (GTP-binding protein BipA) 628 68.146 Strong candidate 0.3665 ProteomeLM contextual shift 0.08828817 1.0 168 1.0 1278 44 0.8084 0.8017 80.17 0.615 1.0 3.6.5.- translation, ribosome, ribosomal ProteomeLM contextual percentile 0.37; strong pocket/AF2Bind evidence; essential-process annotation; high-confidence Boltz2 model; matched: translation, ribosome, ribosomal /main_page_ml/ML1498 2026-05-30T13:09:52Z 644 ML1708 Q9CBR5 ML1708 cysteine desulfurase (EC 2.8.1.7) 410 68.125 Strong candidate 0.4837 ProteomeLM contextual shift 0.10138877 1.0 112 1.0 1244 28 0.6931 0.8996 89.96 0.36 1.0 2.8.1.7 transferase, cofactor ProteomeLM contextual percentile 0.48; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model; matched: transferase, cofactor /main_page_ml/ML1708 2026-05-30T13:09:52Z 645 ML1878 P30767 fusA efg ML1878 Elongation factor G (EF-G) 701 68.112 Strong candidate 0.5777 ProteomeLM contextual shift 0.11367595 1.0 218 1.0 2127 8 0.7491 0.8467 84.67 0.29 0.8625 translation, ribosome ProteomeLM contextual percentile 0.58; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: translation, ribosome /main_page_ml/ML1878 2026-05-30T13:09:52Z 646 ML1257 Q9CC57 hisD ML1257 MLCB1610.20 Histidinol dehydrogenase (HDH) (EC 1.1.1.23) 449 68.11 Strong candidate 0.2851 ProteomeLM contextual shift 0.077838264 1.0 70 1.0 1371 48 0.7876 0.9432 94.32 0.685 1.0 1.1.1.23 PATHWAY: Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 9/9. nad, dehydrogenase, cofactor ProteomeLM contextual percentile 0.29; strong pocket/AF2Bind evidence; essential-process annotation; high-confidence Boltz2 model; matched: nad, dehydrogenase, cofactor /main_page_ml/ML1257 2026-05-30T13:09:52Z 647 ML2392 Q9CB66 ML2392 Conserved membrane protein 144 68.103 Strong candidate 0.7845 ProteomeLM contextual shift 0.16283146 1.0 10 1.0 448 32 0.9077 0.7022 70.22 0.0 0.8625 ProteomeLM contextual percentile 0.78; strong pocket/AF2Bind evidence /main_page_ml/ML2392 2026-05-30T13:09:52Z 648 ML2581 Q9CD18 ML2581 Integral membrane protein 427 68.092 Strong candidate 0.7763 ProteomeLM contextual shift 0.16039646 1.0 62 1.0 1296 30 0.7968 0.7296 72.96 0.0 0.8625 ProteomeLM contextual percentile 0.78; strong pocket/AF2Bind evidence /main_page_ml/ML2581 2026-05-30T13:09:52Z 649 ML1911 Q7AQ19 ML1911A Uncharacterized protein 71 68.092 Strong candidate 0.646 ProteomeLM contextual shift 0.12434464 1.0 18 1.0 399 64 0.9219 0.8608 86.08 0.215 0.7575 translation, ribosome, ribosomal ProteomeLM contextual percentile 0.65; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: translation, ribosome, ribosomal /main_page_ml/ML1911 2026-05-30T13:09:52Z 650 ML1921 Q9CBI9 ML1921 AB hydrolase-1 domain-containing protein 256 68.02 Strong candidate 0.6297 ProteomeLM contextual shift 0.12170463 1.0 26 1.0 576 128 0.9979 0.9381 93.81 0.08 1.0 hydrolase ProteomeLM contextual percentile 0.63; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: hydrolase /main_page_ml/ML1921 2026-05-30T13:09:52Z 651 ML0639 Q49765 whiB7 whiB ML0639 Transcriptional regulator WhiB 89 68.018 Strong candidate 0.6096 ProteomeLM contextual shift 0.11860741 1.0 16 1.0 312 90 0.8802 0.693 69.3 0.29 0.895 transcription, nad, reductase, cofactor ProteomeLM contextual percentile 0.61; strong pocket/AF2Bind evidence; matched: transcription, nad, reductase, cofactor /main_page_ml/ML0639 2026-05-30T13:09:52Z 652 ML1485 Q9CBY0 ML1485 Uncharacterized protein 207 68.015 Strong candidate 0.7325 ProteomeLM contextual shift 0.14548707 1.0 64 1.0 1074 142 0.9706 0.8754 87.54 0.0 0.8625 ProteomeLM contextual percentile 0.73; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML1485 2026-05-30T13:09:52Z 653 ML1649 Q7AQ35 ML1649 DUF3052 domain-containing protein 140 68.002 Strong candidate 0.7287 ProteomeLM contextual shift 0.14458732 1.0 22 1.0 480 0 0.4394 0.8873 88.73 0.0 0.8625 ProteomeLM contextual percentile 0.73; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML1649 2026-05-30T13:09:52Z 654 ML2451 Q9CB45 deoC ML2451 Deoxyribose-phosphate aldolase (DERA) (EC 4.1.2.4) (2-deoxy-D-ribose 5-phosphate aldolase) (Phosphodeoxyriboaldolase) (Deoxyriboaldolase) 226 67.993 Strong candidate 0.302 ProteomeLM contextual shift 0.07922685 1.0 20 1.0 723 90 0.9848 0.9623 96.23 0.64 1.0 4.1.2.4 PATHWAY: Carbohydrate degradation; 2-deoxy-D-ribose 1-phosphate degradation; D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-alpha-D-ribose 1-phosphate: step 2/2. {ECO:0000255|HAMAP-Rule:MF_00114}. ProteomeLM contextual percentile 0.30; strong pocket/AF2Bind evidence; essential-process annotation; high-confidence Boltz2 model /main_page_ml/ML2451 2026-05-30T13:09:52Z 655 ML2249 Q9CBB9 ML2249 Uncharacterized protein 105 67.982 Strong candidate 0.9148 ProteomeLM contextual shift 0.4015712 1.0 14 1.0 364 98 0.9389 0.339 33.9 0.0 0.7575 ProteomeLM contextual percentile 0.91; strong pocket/AF2Bind evidence /main_page_ml/ML2249 2026-05-30T13:09:52Z 656 ML1654 O69475 acpM ML1654 MLCB1243.21c Meromycolate extension acyl carrier protein (ACP) 115 67.969 Strong candidate 0.7331 ProteomeLM contextual shift 0.14548877 1.0 22 1.0 367 44 0.9528 0.8136 81.36 0.08 0.7575 ProteomeLM contextual percentile 0.73; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML1654 2026-05-30T13:09:52Z 657 ML1315 Q49803 lppK ML1315 B2126_F3_115 MLCB2533.11c Putative lipoprotein LppK 194 67.965 Strong candidate 0.7481 ProteomeLM contextual shift 0.14919102 1.0 36 1.0 406 36 0.9171 0.6556 65.56 0.08 0.8625 ProteomeLM contextual percentile 0.75; strong pocket/AF2Bind evidence /main_page_ml/ML1315 2026-05-30T13:09:52Z 658 ML0838 Q7AQF4 cysE ML0838 Serine acetyltransferase (EC 2.3.1.30) 227 67.964 Strong candidate 0.4229 ProteomeLM contextual shift 0.09483184 1.0 78 1.0 491 74 0.9661 0.7761 77.61 0.52 1.0 2.3.1.30 PATHWAY: Amino-acid biosynthesis; L-cysteine biosynthesis; L-cysteine from L-serine: step 1/2. {ECO:0000256|ARBA:ARBA00004876}. transferase ProteomeLM contextual percentile 0.42; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model; matched: transferase /main_page_ml/ML0838 2026-05-30T13:09:52Z 659 ML0861 Q7AQE7 ML0861 Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex (EC 2.3.1.-) 530 67.96 Strong candidate 0.532 ProteomeLM contextual shift 0.10675132 1.0 48 1.0 1071 22 0.8552 0.7141 71.41 0.36 1.0 2.3.1.- transferase, dehydrogenase, cofactor ProteomeLM contextual percentile 0.53; strong pocket/AF2Bind evidence; functional annotation support; matched: transferase, dehydrogenase, cofactor /main_page_ml/ML0861 2026-05-30T13:09:52Z 660 ML0030 O32871 ML0030 MLB1770.18c Uncharacterized protein ML0030 113 67.953 Strong candidate 0.7832 ProteomeLM contextual shift 0.16273902 1.0 18 1.0 347 16 0.7653 0.6365 63.65 0.08 0.7575 ProteomeLM contextual percentile 0.78; strong pocket/AF2Bind evidence /main_page_ml/ML0030 2026-05-30T13:09:52Z 661 ML0051 Q7AQP1 ML0051 PPE-family protein 302 67.942 Strong candidate 0.8653 ProteomeLM contextual shift 0.22729309 1.0 42 1.0 941 70 0.8147 0.4031 40.31 0.0 0.8625 ProteomeLM contextual percentile 0.87; strong pocket/AF2Bind evidence /main_page_ml/ML0051 2026-05-30T13:09:52Z 662 ML2283 Q9CBA2 ML2283 Uncharacterized protein 104 67.93 Strong candidate 0.8778 ProteomeLM contextual shift 0.25262457 1.0 8 1.0 318 12 0.8391 0.4631 46.31 0.0 0.7575 ProteomeLM contextual percentile 0.88; strong pocket/AF2Bind evidence /main_page_ml/ML2283 2026-05-30T13:09:52Z 663 ML0615 Q9CCN3 subI ML0615 Sulphate-binding protein 348 67.921 Strong candidate 0.6936 ProteomeLM contextual shift 0.13528873 1.0 68 1.0 1056 24 0.7226 0.842 84.2 0.08 0.8625 ProteomeLM contextual percentile 0.69; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML0615 2026-05-30T13:09:52Z 664 ML0520 Q9CCS2 ML0520 Membrane protein 202 67.865 Strong candidate 0.7713 ProteomeLM contextual shift 0.1584344 1.0 20 1.0 629 6 0.6635 0.7244 72.44 0.0 0.8625 ProteomeLM contextual percentile 0.77; strong pocket/AF2Bind evidence /main_page_ml/ML0520 2026-05-30T13:09:52Z 665 ML2270 Q9CBB0 menD ML2270 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase (SEPHCHC synthase) (EC 2.2.1.9) (Menaquinone biosynthesis protein MenD) 556 67.855 Strong candidate 0.3521 ProteomeLM contextual shift 0.086232916 1.0 252 1.0 1704 72 0.824 0.9231 92.31 0.565 1.0 2.2.1.9 PATHWAY: Quinol/quinone metabolism; 1,4-dihydroxy-2-naphthoate biosynthesis; 1,4-dihydroxy-2-naphthoate from chorismate: step 2/7. {ECO:0000255|HAMAP-Rule:MF_01659}.; PATHWAY: Quinol/quinone metabolism; menaquinone biosynthesis. {ECO:0000255|HAMAP-Rule:MF_01659}. menaquinone, enzyme, synthase, cofactor ProteomeLM contextual percentile 0.35; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model; matched: menaquinone, enzyme, synthase, cofactor /main_page_ml/ML2270 2026-05-30T13:09:52Z 666 ML0893 Q7AQD6 ML0893 Probable conserved integral membrane protein 428 67.807 Strong candidate 0.6404 ProteomeLM contextual shift 0.12314203 1.0 92 1.0 873 34 0.9516 0.8794 87.94 0.08 1.0 transferase ProteomeLM contextual percentile 0.64; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: transferase /main_page_ml/ML0893 2026-05-30T13:09:52Z 667 ML2162 Q9CBD7 fadA ML2162 Beta-ketoadipyl CoA thiolase 403 67.78 Strong candidate 0.547 ProteomeLM contextual shift 0.108805634 1.0 46 1.0 1316 214 0.9916 0.9635 96.35 0.2 1.0 transferase ProteomeLM contextual percentile 0.55; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: transferase /main_page_ml/ML2162 2026-05-30T13:09:52Z 668 ML2088 Q9CBE7 ML2088 Cytochrome p450 434 67.757 Strong candidate 0.6466 ProteomeLM contextual shift 0.12435013 1.0 54 1.0 939 142 0.9959 0.8526 85.26 0.08 1.0 oxidoreductase, reductase, cofactor ProteomeLM contextual percentile 0.65; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: oxidoreductase, reductase, cofactor /main_page_ml/ML2088 2026-05-30T13:09:52Z 669 ML2377 P54880 ML2377 u1740w Probable transport accessory protein MmpS4 154 67.729 Strong candidate 0.7218 ProteomeLM contextual shift 0.14310688 1.0 12 1.0 522 0 0.4236 0.7241 72.41 0.08 0.8625 ProteomeLM contextual percentile 0.72; strong pocket/AF2Bind evidence /main_page_ml/ML2377 2026-05-30T13:09:52Z 670 ML0228 Q7AQL3 ML0228 Membrane protein 432 67.725 Strong candidate 0.8853 ProteomeLM contextual shift 0.2743253 1.0 36 1.0 1357 82 0.9687 0.3113 31.13 0.0 0.8625 ProteomeLM contextual percentile 0.89; strong pocket/AF2Bind evidence /main_page_ml/ML0228 2026-05-30T13:09:52Z 671 ML1065 Q7AQ97 ML1065 Cell division protein DivIVA 114 67.723 Strong candidate 0.8484 ProteomeLM contextual shift 0.20461054 1.0 8 1.0 268 80 0.9293 0.4555 45.55 0.045 0.7575 cell division ProteomeLM contextual percentile 0.85; strong pocket/AF2Bind evidence; matched: cell division /main_page_ml/ML1065 2026-05-30T13:09:52Z 672 ML2396 Q9CB65 cysM2 ML2396 Cystathionine beta-synthase (EC 4.2.1.22) 464 67.692 Strong candidate 0.4756 ProteomeLM contextual shift 0.10046355 1.0 130 1.0 1451 118 0.9624 0.8847 88.47 0.36 1.0 4.2.1.22 synthase, cofactor ProteomeLM contextual percentile 0.48; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model; matched: synthase, cofactor /main_page_ml/ML2396 2026-05-30T13:09:52Z 673 ML1756 Q9CBP1 mmr ML1756 Multidrug resistance protein mmr 107 67.652 Strong candidate 0.735 ProteomeLM contextual shift 0.1457214 1.0 24 1.0 342 42 0.9535 0.7754 77.54 0.08 0.7575 ProteomeLM contextual percentile 0.73; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML1756 2026-05-30T13:09:52Z 674 ML1791 Q9CBN1 ML1791 RNA-binding protein 147 67.61 Strong candidate 0.7206 ProteomeLM contextual shift 0.1423801 1.0 22 1.0 466 10 0.7162 0.8766 87.66 0.0 0.8625 ProteomeLM contextual percentile 0.72; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML1791 2026-05-30T13:09:52Z 675 ML2634 Q9CCZ8 pntB ML2634 NAD(P) transhydrogenase subunit beta (EC 7.1.1.1) (Nicotinamide nucleotide transhydrogenase subunit beta) 472 67.608 Strong candidate 0.4699 ProteomeLM contextual shift 0.09993688 1.0 74 1.0 1463 94 0.9532 0.806 80.6 0.405 1.0 7.1.1.1 nad ProteomeLM contextual percentile 0.47; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model; matched: nad /main_page_ml/ML2634 2026-05-30T13:09:52Z 676 ML0106 Q9CDA7 embC ML0106 Probable arabinosyltransferase C (EC 2.4.2.-) 1070 67.599 Strong candidate 0.5276 ProteomeLM contextual shift 0.106382996 1.0 328 1.0 3270 0 0.4343 0.9184 91.84 0.285 0.925 2.4.2.- cell wall, transferase ProteomeLM contextual percentile 0.53; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: cell wall, transferase /main_page_ml/ML0106 2026-05-30T13:09:52Z 677 ML1675 Q9CBS3 ung ML1675 Uracil-DNA glycosylase (UDG) (EC 3.2.2.27) 227 67.595 Strong candidate 0.3878 ProteomeLM contextual shift 0.091115996 1.0 25 1.0 713 64 0.8957 0.942 94.2 0.48 1.0 3.2.2.27 ProteomeLM contextual percentile 0.39; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model /main_page_ml/ML1675 2026-05-30T13:09:52Z 678 ML1504 Q9CBX0 ML1504 Probable conserved membrane protein 430 67.566 Strong candidate 0.6366 ProteomeLM contextual shift 0.12235 1.0 87 1.0 1333 86 0.9401 0.8686 86.86 0.08 1.0 transferase ProteomeLM contextual percentile 0.64; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: transferase /main_page_ml/ML1504 2026-05-30T13:09:52Z 679 ML1932 Q9CBI1 ML1932 Transmembrane protein 137 67.554 Strong candidate 0.8421 ProteomeLM contextual shift 0.19847153 1.0 14 1.0 443 64 0.9072 0.4455 44.55 0.0 0.8625 ProteomeLM contextual percentile 0.84; strong pocket/AF2Bind evidence /main_page_ml/ML1932 2026-05-30T13:09:52Z 680 ML0806 Q9CCH6 ML0806 Membrane protein 173 67.537 Strong candidate 0.7663 ProteomeLM contextual shift 0.15657441 1.0 24 1.0 542 46 0.8445 0.7092 70.92 0.0 0.8625 ProteomeLM contextual percentile 0.77; strong pocket/AF2Bind evidence /main_page_ml/ML0806 2026-05-30T13:09:52Z 681 ML1983 Q9CBH1 ML1983 Polyketide cyclase 155 67.528 Strong candidate 0.708 ProteomeLM contextual shift 0.13888188 1.0 16 1.0 528 126 0.9846 0.9122 91.22 0.0 0.8625 ProteomeLM contextual percentile 0.71; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML1983 2026-05-30T13:09:52Z 682 ML2596 Q9CD07 ML2596 Conserved membrane protein 325 67.524 Strong candidate 0.6911 ProteomeLM contextual shift 0.13287373 1.0 50 1.0 978 6 0.8187 0.811 81.1 0.08 0.8625 ProteomeLM contextual percentile 0.69; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML2596 2026-05-30T13:09:52Z 683 ML1938 Q9X781 ispH lytB lytB2 ML1938 MLCB1222.06c 4-hydroxy-3-methylbut-2-enyl diphosphate reductase (HMBPP reductase) (EC 1.17.7.4) 332 67.52 Strong candidate 0.2826 ProteomeLM contextual shift 0.077543 1.0 46 1.0 1018 26 0.727 0.8929 89.29 0.685 1.0 1.17.7.4 PATHWAY: Isoprenoid biosynthesis; dimethylallyl diphosphate biosynthesis; dimethylallyl diphosphate from (2E)-4-hydroxy-3-methylbutenyl diphosphate: step 1/1. {ECO:0000255|HAMAP-Rule:MF_00191}.; PATHWAY: Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 6/6. {ECO:0000255|HAMAP-Rule:MF_00191}. isoprenoid, reductase, cofactor ProteomeLM contextual percentile 0.28; strong pocket/AF2Bind evidence; essential-process annotation; high-confidence Boltz2 model; matched: isoprenoid, reductase, cofactor /main_page_ml/ML1938 2026-05-30T13:09:52Z 684 ML2454 Q9CB42 hbhA ML2454 Heparin-binding hemagglutinin homolog (Adhesin) 188 67.514 Strong candidate 0.8221 ProteomeLM contextual shift 0.1821785 1.0 18 1.0 604 40 0.947 0.5118 51.18 0.0 0.8625 ProteomeLM contextual percentile 0.82; strong pocket/AF2Bind evidence /main_page_ml/ML2454 2026-05-30T13:09:52Z 685 ML0825 Q9CCG5 ML0825 ArsR-family transcriptional regulator 140 67.488 Strong candidate 0.693 ProteomeLM contextual shift 0.13526998 1.0 12 1.0 436 32 0.7932 0.7109 71.09 0.125 0.8625 transcription ProteomeLM contextual percentile 0.69; strong pocket/AF2Bind evidence; matched: transcription /main_page_ml/ML0825 2026-05-30T13:09:52Z 686 ML1769 Q9CBN7 uspE ML1769 Sugar transport integral membrane protein 274 67.477 Strong candidate 0.6967 ProteomeLM contextual shift 0.13596992 1.0 53 1.0 846 48 0.9526 0.7866 78.66 0.08 0.8625 ProteomeLM contextual percentile 0.70; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML1769 2026-05-30T13:09:52Z 687 ML2349 Q49939 papA5 ML2349 MLCB2407.01 Phthiocerol/phthiodiolone dimycocerosyl transferase (EC 2.3.1.282) (Acyltransferase PapA5) (Phthiocerol/phthiodiolone O-acyltransferase) (Polyketide synthase-associated protein A5) 423 67.438 Strong candidate 0.411 ProteomeLM contextual shift 0.09329837 1.0 108 1.0 1387 236 0.9791 0.8452 84.52 0.48 1.0 2.3.1.282 transferase, synthase ProteomeLM contextual percentile 0.41; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model; matched: transferase, synthase /main_page_ml/ML2349 2026-05-30T13:09:52Z 688 ML0911 O69555 mraY murX ML0911 MLCB268.05c Phospho-N-acetylmuramoyl-pentapeptide-transferase (EC 2.7.8.13) (UDP-MurNAc-pentapeptide phosphotransferase) 359 67.418 Strong candidate 0.2412 ProteomeLM contextual shift 0.071076676 1.0 108 1.0 1080 6 0.72 0.9075 90.75 0.745 1.0 2.7.8.13 PATHWAY: Cell wall biogenesis; peptidoglycan biosynthesis. {ECO:0000255|HAMAP-Rule:MF_00038}. cell division, peptidoglycan, cell wall, mur, transferase, cofactor ProteomeLM contextual percentile 0.24; strong pocket/AF2Bind evidence; essential-process annotation; high-confidence Boltz2 model; matched: cell division, peptidoglycan, cell wall, mur, transferase /main_page_ml/ML0911 2026-05-30T13:09:52Z 689 ML0481 P40834 ruvC ML0481 B1177_C3_226 Crossover junction endodeoxyribonuclease RuvC (EC 3.1.21.10) (Holliday junction nuclease RuvC) (Holliday junction resolvase RuvC) 188 67.386 Strong candidate 0.401 ProteomeLM contextual shift 0.09257349 1.0 54 1.0 572 16 0.6242 0.8751 87.51 0.48 1.0 3.1.21.10 cofactor ProteomeLM contextual percentile 0.40; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model; matched: cofactor /main_page_ml/ML0481 2026-05-30T13:09:52Z 690 ML1158 P46707 fadA4 ML1158 B1549_C1_166 Probable acetyl-CoA acetyltransferase (EC 2.3.1.9) (Acetoacetyl-CoA thiolase) 393 67.365 Strong candidate 0.3741 ProteomeLM contextual shift 0.089171596 1.0 88 1.0 1241 124 0.9664 0.9673 96.73 0.48 1.0 2.3.1.9 transferase ProteomeLM contextual percentile 0.37; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model; matched: transferase /main_page_ml/ML1158 2026-05-30T13:09:52Z 691 ML2682 P46385 rplI ML2682 MLCB1913.18c Large ribosomal subunit protein bL9 (50S ribosomal protein L9) 152 67.351 Strong candidate 0.5934 ProteomeLM contextual shift 0.116446614 1.0 8 1.0 460 8 0.8174 0.8659 86.59 0.215 0.8625 translation, ribosome, ribosomal ProteomeLM contextual percentile 0.59; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: translation, ribosome, ribosomal /main_page_ml/ML2682 2026-05-30T13:09:52Z 692 ML1278 Q9CC48 tesB ML1278 Acyl CoA thioesterase II 297 67.345 Strong candidate 0.6115 ProteomeLM contextual shift 0.118803315 1.0 79 1.0 954 126 0.9975 0.9341 93.41 0.08 1.0 hydrolase ProteomeLM contextual percentile 0.61; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: hydrolase /main_page_ml/ML1278 2026-05-30T13:09:52Z 693 ML2713 P46386 rpmH ML2713 Large ribosomal subunit protein bL34 (50S ribosomal protein L34) 47 67.343 Strong candidate 0.6454 ProteomeLM contextual shift 0.12423841 1.0 8 1.0 106 24 0.9087 0.788 78.8 0.215 0.7575 translation, ribosome, ribosomal ProteomeLM contextual percentile 0.65; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: translation, ribosome, ribosomal /main_page_ml/ML2713 2026-05-30T13:09:52Z 694 ML2172 Q9CBD4 ML2172 Uncharacterized protein 118 67.314 Strong candidate 0.8734 ProteomeLM contextual shift 0.24490881 1.0 12 1.0 400 92 0.9859 0.4169 41.69 0.0 0.7575 ProteomeLM contextual percentile 0.87; strong pocket/AF2Bind evidence /main_page_ml/ML2172 2026-05-30T13:09:52Z 695 ML0242 Q9CD51 ispE ML0242 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase (CMK) (EC 2.7.1.148) (4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase) 323 67.263 Strong candidate 0.2738 ProteomeLM contextual shift 0.07627435 1.0 30 1.0 988 110 0.9414 0.8979 89.79 0.685 1.0 2.7.1.148 PATHWAY: Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 3/6. {ECO:0000255|HAMAP-Rule:MF_00061}. isoprenoid, kinase ProteomeLM contextual percentile 0.27; strong pocket/AF2Bind evidence; essential-process annotation; high-confidence Boltz2 model; matched: isoprenoid, kinase /main_page_ml/ML0242 2026-05-30T13:09:52Z 696 ML2341 Q9CB72 ML2341 Possible regulatory protein 732 67.24 Strong candidate 0.6723 ProteomeLM contextual shift 0.12963378 1.0 158 1.0 2218 4 0.5245 0.8484 84.84 0.08 0.8625 ProteomeLM contextual percentile 0.67; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML2341 2026-05-30T13:09:52Z 697 ML2529 Q9CD35 ML2529 Conserved membrane protein 485 67.233 Strong candidate 0.7024 ProteomeLM contextual shift 0.13730316 1.0 90 1.0 981 22 0.8832 0.7424 74.24 0.08 0.8625 ProteomeLM contextual percentile 0.70; strong pocket/AF2Bind evidence /main_page_ml/ML2529 2026-05-30T13:09:52Z 698 ML1269 Q9X7C5 trpE ML1269 MLCB1610.31 Anthranilate synthase component 1 (AS) (ASI) (EC 4.1.3.27) 529 67.216 Strong candidate 0.3026 ProteomeLM contextual shift 0.07931665 1.0 212 1.0 1075 34 0.8805 0.8824 88.24 0.64 1.0 4.1.3.27 PATHWAY: Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 1/5. synthase, cofactor ProteomeLM contextual percentile 0.30; strong pocket/AF2Bind evidence; essential-process annotation; high-confidence Boltz2 model; matched: synthase, cofactor /main_page_ml/ML1269 2026-05-30T13:09:52Z 699 ML1622 O33013 ffh ML1622 MLCB250.20 Signal recognition particle protein (EC 3.6.5.4) (Fifty-four homolog) 521 67.215 Strong candidate 0.4185 ProteomeLM contextual shift 0.094188266 1.0 54 1.0 1592 18 0.7079 0.7065 70.65 0.525 1.0 3.6.5.4 translation ProteomeLM contextual percentile 0.42; strong pocket/AF2Bind evidence; functional annotation support; matched: translation /main_page_ml/ML1622 2026-05-30T13:09:52Z 700 ML1814 Q9CBL3 acn ML1814 Aconitate hydratase A (EC 4.2.1.3) (EC 4.2.1.99) ((2R,3S)-2-methylisocitrate dehydratase) ((2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate dehydratase) (Iron-responsive protein-like) (Probable 2-methyl-cis-aconitate hydratase) (RNA-binding protein) 944 67.169 Strong candidate 0.3828 ProteomeLM contextual shift 0.09054197 1.0 188 1.0 2892 0 0.4193 0.9119 91.19 0.52 0.925 4.2.1.3; 4.2.1.99 PATHWAY: Carbohydrate metabolism; tricarboxylic acid cycle; isocitrate from oxaloacetate: step 2/2. {ECO:0000256|ARBA:ARBA00004717}.; PATHWAY: Organic acid metabolism; propanoate degradation. {ECO:0000256|ARBA:ARBA00005026}. isomerase, cofactor ProteomeLM contextual percentile 0.38; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model; matched: isomerase, cofactor /main_page_ml/ML1814 2026-05-30T13:09:52Z 701 ML2308 Q9CB85 pon1 ML2308 Penicillin binding protein (Class A) 803 67.163 Strong candidate 0.5038 ProteomeLM contextual shift 0.103453256 1.0 101 1.0 2469 0 0.249 0.8582 85.82 0.335 0.925 peptidoglycan, mur, d-alanine, transferase ProteomeLM contextual percentile 0.50; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: peptidoglycan, mur, d-alanine, transferase /main_page_ml/ML2308 2026-05-30T13:09:52Z 702 ML2433 P54580 ML2433 B2168_C2_209 Uncharacterized protein ML2433 355 67.095 Strong candidate 0.8164 ProteomeLM contextual shift 0.17727275 1.0 32 1.0 1093 16 0.8301 0.3295 32.95 0.08 0.8625 ProteomeLM contextual percentile 0.82; strong pocket/AF2Bind evidence /main_page_ml/ML2433 2026-05-30T13:09:52Z 703 ML2207 Q7APX7 ML2207 Bacterial SCP orthologue domain-containing protein 131 67.021 Strong candidate 0.6942 ProteomeLM contextual shift 0.13544473 1.0 8 1.0 268 12 0.6576 0.9098 90.98 0.0 0.8625 ProteomeLM contextual percentile 0.69; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML2207 2026-05-30T13:09:52Z 704 ML1879 P30764 rpsG ML1879 Small ribosomal subunit protein uS7 (30S ribosomal protein S7) 156 67.015 Strong candidate 0.5746 ProteomeLM contextual shift 0.112991676 1.0 12 1.0 770 42 0.8605 0.898 89.8 0.215 0.8625 translation, ribosome, ribosomal ProteomeLM contextual percentile 0.57; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: translation, ribosome, ribosomal /main_page_ml/ML1879 2026-05-30T13:09:52Z 705 ML0735 P46701 purK ML0735 B1308_F1_32 N5-carboxyaminoimidazole ribonucleotide synthase (N5-CAIR synthase) (EC 6.3.4.18) (5-(carboxyamino)imidazole ribonucleotide synthetase) 439 66.998 Strong candidate 0.2926 ProteomeLM contextual shift 0.07859606 1.0 44 1.0 1359 84 0.9536 0.8957 89.57 0.64 1.0 6.3.4.18 PATHWAY: Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate from 5-amino-1-(5-phospho-D-ribosyl)imidazole (N5-CAIR route): step 1/2. {ECO:0000255|HAMAP-Rule:MF_01928}. synthetase, synthase ProteomeLM contextual percentile 0.29; strong pocket/AF2Bind evidence; essential-process annotation; high-confidence Boltz2 model; matched: synthetase, synthase /main_page_ml/ML0735 2026-05-30T13:09:52Z 706 ML0048 Q9CDD8 ML0048 CobQ/CobB/MinD/ParA nucleotide binding domain-containing protein 586 66.996 Strong candidate 0.7256 ProteomeLM contextual shift 0.14369528 1.0 66 1.0 1212 0 0.4578 0.5476 54.76 0.125 0.8625 cell division ProteomeLM contextual percentile 0.73; strong pocket/AF2Bind evidence; matched: cell division /main_page_ml/ML0048 2026-05-30T13:09:52Z 707 ML1076 Q9CCA6 sigE ML1076 ECF subfamily sigma subunit 263 66.982 Strong candidate 0.7155 ProteomeLM contextual shift 0.14079614 1.0 30 1.0 821 64 0.892 0.5813 58.13 0.125 0.8625 transcription ProteomeLM contextual percentile 0.72; strong pocket/AF2Bind evidence; matched: transcription /main_page_ml/ML1076 2026-05-30T13:09:52Z 708 ML2534 Q9CD31 ML2534 PE-family protein 102 66.957 Strong candidate 0.7343 ProteomeLM contextual shift 0.14552741 1.0 48 1.0 341 70 0.8774 0.868 86.8 0.0 0.7575 ProteomeLM contextual percentile 0.73; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML2534 2026-05-30T13:09:52Z 709 ML0419 Q9CCU7 ML0419 Putative tRNA (cytidine(34)-2'-O)-methyltransferase (EC 2.1.1.207) (tRNA (cytidine/uridine-2'-O-)-methyltransferase) 158 66.957 Strong candidate 0.3847 ProteomeLM contextual shift 0.09066009 1.0 28 1.0 509 70 0.8765 0.8892 88.92 0.48 1.0 2.1.1.207 transferase ProteomeLM contextual percentile 0.38; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model; matched: transferase /main_page_ml/ML0419 2026-05-30T13:09:52Z 710 ML2426 Q49807 cmaA2 ML2426 B2168_F3_130 Cyclopropane mycolic acid synthase 2 (CMAS) (EC 2.1.1.79) (Cyclopropane-fatty-acyl-phospholipid synthase) (CFA synthase) (Cyclopropane fatty acid synthase) (Mycolic acid methyltransferase) (MA-MT) (S-adenosylmethionine-dependent methyltransferase) (AdoMet-MT) (SAM-MT) 308 66.942 Strong candidate 0.2293 ProteomeLM contextual shift 0.06996053 1.0 52 1.0 1013 178 0.9988 0.9315 93.15 0.73 1.0 2.1.1.79 PATHWAY: Lipid metabolism; mycolic acid biosynthesis. mycolic, lipid metabolism, transferase, synthase ProteomeLM contextual percentile 0.23; strong pocket/AF2Bind evidence; essential-process annotation; high-confidence Boltz2 model; matched: mycolic, lipid metabolism, transferase, synthase /main_page_ml/ML2426 2026-05-30T13:09:52Z 711 ML1214 Q9CC67 ML1214 Secreted p60-family protein 212 66.908 Strong candidate 0.7036 ProteomeLM contextual shift 0.13751495 1.0 27 1.0 427 6 0.5919 0.7056 70.56 0.08 0.8625 ProteomeLM contextual percentile 0.70; strong pocket/AF2Bind evidence /main_page_ml/ML1214 2026-05-30T13:09:52Z 712 ML1139 P45829 atpB ML1139 ATP synthase subunit a (ATP synthase F0 sector subunit a) (F-ATPase subunit 6) 251 66.889 Strong candidate 0.6247 ProteomeLM contextual shift 0.12085328 1.0 46 1.0 776 46 0.884 0.7525 75.25 0.125 1.0 atp synthase, synthase ProteomeLM contextual percentile 0.62; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: atp synthase, synthase /main_page_ml/ML1139 2026-05-30T13:09:52Z 713 ML1584 Q9CBU2 ML1584 Uncharacterized protein ML1584 84 66.859 Strong candidate 0.7707 ProteomeLM contextual shift 0.1584267 1.0 14 1.0 284 64 0.9447 0.571 57.1 0.08 0.7575 ProteomeLM contextual percentile 0.77; strong pocket/AF2Bind evidence /main_page_ml/ML1584 2026-05-30T13:09:52Z 714 ML1357 Q9CC31 ML1357 Uncharacterized protein 61 66.829 Strong candidate 0.7682 ProteomeLM contextual shift 0.15711774 1.0 8 1.0 187 8 0.7523 0.7368 73.68 0.0 0.7575 ProteomeLM contextual percentile 0.77; strong pocket/AF2Bind evidence /main_page_ml/ML1357 2026-05-30T13:09:52Z 715 ML1392 Q9CC24 uvrA ML1392 UvrABC system protein A (UvrA protein) (Excinuclease ABC subunit A) 969 66.82 Strong candidate 0.6084 ProteomeLM contextual shift 0.11837763 1.0 201 1.0 1943 10 0.5957 0.8651 86.51 0.2 0.7875 ProteomeLM contextual percentile 0.61; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML1392 2026-05-30T13:09:52Z 716 ML0102 Q9CDB0 accD4 ML0102 Acyl CoA carboxylase [beta] subunit 517 66.817 Strong candidate 0.6416 ProteomeLM contextual shift 0.1232533 1.0 80 1.0 1561 20 0.7714 0.9136 91.36 0.08 0.8625 ProteomeLM contextual percentile 0.64; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML0102 2026-05-30T13:09:52Z 717 ML2205 Q9CBC2 purM ML2205 Phosphoribosylformylglycinamidine cyclo-ligase (EC 6.3.3.1) (AIR synthase) (AIRS) (Phosphoribosyl-aminoimidazole synthetase) 364 66.805 Strong candidate 0.3565 ProteomeLM contextual shift 0.0869105 1.0 47 1.0 747 38 0.9383 0.8927 89.27 0.52 1.0 6.3.3.1 PATHWAY: Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 2/2. {ECO:0000256|ARBA:ARBA00004686, ECO:0000256|HAMAP-Rule:MF_00741}. ligase, synthetase, synthase ProteomeLM contextual percentile 0.36; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model; matched: ligase, synthetase, synthase /main_page_ml/ML2205 2026-05-30T13:09:52Z 718 ML0540 Q9CCQ8 mihF ML0540 Integration host factor 105 66.79 Strong candidate 0.6767 ProteomeLM contextual shift 0.13028905 1.0 8 1.0 333 36 0.749 0.893 89.3 0.08 0.7575 ProteomeLM contextual percentile 0.68; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML0540 2026-05-30T13:09:52Z 719 ML0042 Q7AQP3 ML0042 Membrane protein 467 66.783 Strong candidate 0.651 ProteomeLM contextual shift 0.1252979 1.0 72 1.0 1442 2 0.5516 0.8773 87.73 0.08 0.8625 ProteomeLM contextual percentile 0.65; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML0042 2026-05-30T13:09:52Z 720 ML0921 Q9CCE0 ML0921 Possible membrane protein 96 66.779 Strong candidate 0.6792 ProteomeLM contextual shift 0.13070512 1.0 8 1.0 295 14 0.7912 0.8832 88.32 0.08 0.7575 ProteomeLM contextual percentile 0.68; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML0921 2026-05-30T13:09:52Z 721 ML2289 Q9CB99 ML2289 Fido domain-containing protein 256 66.752 Strong candidate 0.6861 ProteomeLM contextual shift 0.13119811 1.0 34 1.0 522 20 0.909 0.9114 91.14 0.0 0.8625 ProteomeLM contextual percentile 0.69; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML2289 2026-05-30T13:09:52Z 722 ML0559 Q9CCP4 ribA ribBA ML0559 Riboflavin biosynthesis protein RibBA [Includes: 3,4-dihydroxy-2-butanone 4-phosphate synthase (DHBP synthase) (EC 4.1.99.12); GTP cyclohydrolase-2 (EC 3.5.4.25) (GTP cyclohydrolase II)] 435 66.699 Strong candidate 0.2757 ProteomeLM contextual shift 0.07665734 1.0 150 1.0 891 42 0.9297 0.835 83.5 0.685 1.0 3.5.4.25; 4.1.99.12 PATHWAY: Cofactor biosynthesis; riboflavin biosynthesis; 2-hydroxy-3-oxobutyl phosphate from D-ribulose 5-phosphate: step 1/1. {ECO:0000256|ARBA:ARBA00004904, ECO:0000256|HAMAP-Rule:MF_01283}.; PATHWAY: Cofactor biosynthesis; riboflavin biosynthesis; 5-amino-6-(D-ribitylamino)uracil from GTP: step 1/4. {ECO:0000256|ARBA:ARBA00004853, ECO:0000256|HAMAP-Rule:MF_01283}. cofactor biosynthesis, hydrolase, synthase, cofactor ProteomeLM contextual percentile 0.28; strong pocket/AF2Bind evidence; essential-process annotation; high-confidence Boltz2 model; matched: cofactor biosynthesis, hydrolase, synthase, cofactor /main_page_ml/ML0559 2026-05-30T13:09:52Z 723 ML1244 Q7AQ82 ML1244 Diacylglycerol O-acyltransferase (EC 2.3.1.20) 491 66.697 Strong candidate 0.3534 ProteomeLM contextual shift 0.086527735 1.0 106 1.0 1589 232 0.9894 0.8028 80.28 0.565 1.0 2.3.1.20 PATHWAY: Glycerolipid metabolism; triacylglycerol biosynthesis. {ECO:0000256|ARBA:ARBA00004771, ECO:0000256|RuleBase:RU361241}.; PATHWAY: Lipid metabolism. {ECO:0000256|ARBA:ARBA00005189}. lipid metabolism, transferase ProteomeLM contextual percentile 0.35; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model; matched: lipid metabolism, transferase /main_page_ml/ML1244 2026-05-30T13:09:52Z 724 ML2295 Q9CB98 ML2295 Protease 234 66.691 Strong candidate 0.6523 ProteomeLM contextual shift 0.12543394 1.0 26 1.0 762 0 0.2849 0.8862 88.62 0.0 1.0 protease ProteomeLM contextual percentile 0.65; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: protease /main_page_ml/ML2295 2026-05-30T13:09:52Z 725 ML1058 Q7AQ99 dapD ML1058 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase (EC 2.3.1.117) (Tetrahydrodipicolinate N-succinyltransferase) (THDP succinyltransferase) (THP succinyltransferase) (Tetrahydropicolinate succinylase) 317 66.677 Strong candidate 0.2801 ProteomeLM contextual shift 0.07740726 1.0 122 1.0 971 40 0.8952 0.9074 90.74 0.64 1.0 2.3.1.117 PATHWAY: Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; LL-2,6-diaminopimelate from (S)-tetrahydrodipicolinate (succinylase route): step 1/3. {ECO:0000256|HAMAP-Rule:MF_02122}. transferase ProteomeLM contextual percentile 0.28; strong pocket/AF2Bind evidence; essential-process annotation; high-confidence Boltz2 model; matched: transferase /main_page_ml/ML1058 2026-05-30T13:09:52Z 726 ML2237 P49774 ML2237 MLCB5.04c u296a Uncharacterized HIT-like protein ML2237 134 66.673 Strong candidate 0.6266 ProteomeLM contextual shift 0.121065095 1.0 46 1.0 456 108 0.9827 0.9518 95.18 0.08 0.8625 ProteomeLM contextual percentile 0.63; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML2237 2026-05-30T13:09:52Z 727 ML0606 Q49770 ML0606 DUF403 domain-containing protein 325 66.664 Strong candidate 0.6986 ProteomeLM contextual shift 0.13614148 1.0 50 1.0 995 40 0.8986 0.8587 85.87 0.0 0.8625 ProteomeLM contextual percentile 0.70; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML0606 2026-05-30T13:09:52Z 728 ML2388 Q7APV4 ML2388 Possible membrane protein 101 66.659 Strong candidate 0.7538 ProteomeLM contextual shift 0.15079819 1.0 22 1.0 344 82 0.9125 0.7702 77.02 0.0 0.7575 ProteomeLM contextual percentile 0.75; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML2388 2026-05-30T13:09:52Z 729 ML0775 Q9CCJ0 lpqB ML0775 Lipoprotein LpqB 589 66.648 Strong candidate 0.6504 ProteomeLM contextual shift 0.12495512 1.0 98 1.0 1827 0 0.4208 0.866 86.6 0.08 0.8625 ProteomeLM contextual percentile 0.65; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML0775 2026-05-30T13:09:52Z 730 ML0303 Q9CCX0 glnH ML0303 Glutamine-binding protein 326 66.643 Strong candidate 0.6554 ProteomeLM contextual shift 0.12658009 1.0 60 1.0 1004 52 0.8608 0.8479 84.79 0.08 0.8625 ProteomeLM contextual percentile 0.66; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML0303 2026-05-30T13:09:52Z 731 ML1061 Q7AQ98 ML1061 Cytokinin riboside 5'-monophosphate phosphoribohydrolase (EC 3.2.2.n1) 187 66.643 Strong candidate 0.4442 ProteomeLM contextual shift 0.097101144 1.0 92 1.0 589 56 0.8212 0.8895 88.95 0.36 1.0 3.2.2.n1 hydrolase ProteomeLM contextual percentile 0.44; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model; matched: hydrolase /main_page_ml/ML1061 2026-05-30T13:09:52Z 732 ML1149 P53523 ML1149 u471a Corrinoid adenosyltransferase (EC 2.5.1.17) (Cob(II)alamin adenosyltransferase) (Cob(II)yrinic acid a,c-diamide adenosyltransferase) (Cobinamide/cobalamin adenosyltransferase) 191 66.619 Strong candidate 0.2594 ProteomeLM contextual shift 0.07435604 1.0 43 1.0 605 64 0.9538 0.884 88.4 0.685 1.0 2.5.1.17 PATHWAY: Cofactor biosynthesis; adenosylcobalamin biosynthesis; adenosylcobalamin from cob(II)yrinate a,c-diamide: step 2/7. cofactor biosynthesis, transferase, cofactor ProteomeLM contextual percentile 0.26; strong pocket/AF2Bind evidence; essential-process annotation; high-confidence Boltz2 model; matched: cofactor biosynthesis, transferase, cofactor /main_page_ml/ML1149 2026-05-30T13:09:52Z 733 ML0494 P46696 hisS ML0494 B1177_C3_248 MLCB1259.12 Histidine--tRNA ligase (EC 6.1.1.21) (Histidyl-tRNA synthetase) (HisRS) 427 66.611 Strong candidate 0.3897 ProteomeLM contextual shift 0.091510676 1.0 56 1.0 1307 52 0.7801 0.8971 89.71 0.45 1.0 6.1.1.21 aminoacyl-trna, trna ligase, ligase, synthetase ProteomeLM contextual percentile 0.39; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model; matched: aminoacyl-trna, trna ligase, ligase, synthetase /main_page_ml/ML0494 2026-05-30T13:09:52Z 734 ML2457 Q9CB41 ML2457 Possible TetR-family transcriptional regulator 233 66.584 Strong candidate 0.6278 ProteomeLM contextual shift 0.12112168 1.0 52 1.0 780 162 0.9802 0.8485 84.85 0.125 0.8625 transcription ProteomeLM contextual percentile 0.63; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: transcription /main_page_ml/ML2457 2026-05-30T13:09:52Z 735 ML0593 Q49689 ML0593 B1496_C2_189 MLCL536.28c Iron-sulfur cluster assembly SufBD family protein ML0593 [Cleaved into: Mle pps1 intein] 869 66.572 Strong candidate 0.7061 ProteomeLM contextual shift 0.13798515 1.0 146 1.0 1740 4 0.6719 0.7382 73.82 0.08 0.7875 ProteomeLM contextual percentile 0.71; strong pocket/AF2Bind evidence /main_page_ml/ML0593 2026-05-30T13:09:52Z 736 ML1678 Q9CBS0 ddl ddlA ML1678 D-alanine--D-alanine ligase (EC 6.3.2.4) (D-Ala-D-Ala ligase) (D-alanylalanine synthetase) 384 66.567 Strong candidate 0.213 ProteomeLM contextual shift 0.06754805 1.0 121 1.0 1229 154 0.9832 0.861 86.1 0.775 1.0 6.3.2.4 PATHWAY: Cell wall biogenesis; peptidoglycan biosynthesis. {ECO:0000255|HAMAP-Rule:MF_00047}. peptidoglycan, cell wall, d-alanine, ligase, synthetase, cofactor ProteomeLM contextual percentile 0.21; strong pocket/AF2Bind evidence; essential-process annotation; high-confidence Boltz2 model; matched: peptidoglycan, cell wall, d-alanine, ligase, synthetase /main_page_ml/ML1678 2026-05-30T13:09:52Z 737 ML0558 Q9CCP5 ribC ML0558 Riboflavin synthase (EC 2.5.1.9) 207 66.517 Strong candidate 0.3139 ProteomeLM contextual shift 0.08062647 1.0 38 1.0 667 12 0.6485 0.9231 92.31 0.565 1.0 2.5.1.9 PATHWAY: Cofactor biosynthesis; riboflavin biosynthesis; riboflavin from 2-hydroxy-3-oxobutyl phosphate and 5-amino-6-(D-ribitylamino)uracil: step 2/2. {ECO:0000256|ARBA:ARBA00004887}. cofactor biosynthesis, synthase, cofactor ProteomeLM contextual percentile 0.31; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model; matched: cofactor biosynthesis, synthase, cofactor /main_page_ml/ML0558 2026-05-30T13:09:52Z 738 ML2390 Q9CB67 ML2390 Possible secreted protein 101 66.502 Strong candidate 0.8321 ProteomeLM contextual shift 0.18954484 1.0 16 1.0 352 98 0.9655 0.4804 48.04 0.0 0.7575 ProteomeLM contextual percentile 0.83; strong pocket/AF2Bind evidence /main_page_ml/ML2390 2026-05-30T13:09:52Z 739 ML1617 O33015 khpA ML1617 MLCB250.30 RNA-binding protein KhpA (KH-domain protein A) 80 66.496 Strong candidate 0.6704 ProteomeLM contextual shift 0.12947315 1.0 14 1.0 245 10 0.6932 0.8856 88.56 0.08 0.7575 ProteomeLM contextual percentile 0.67; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML1617 2026-05-30T13:09:52Z 740 ML1784 Q9CBN2 adhE2 ML1784 Alcohol dehydrogenase (Zn dependent) 361 66.476 Strong candidate 0.5589 ProteomeLM contextual shift 0.11018873 1.0 70 1.0 778 112 0.9897 0.9415 94.15 0.125 1.0 nad, dehydrogenase, cofactor ProteomeLM contextual percentile 0.56; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: nad, dehydrogenase, cofactor /main_page_ml/ML1784 2026-05-30T13:09:52Z 741 ML2412 Q9CB61 ML2412 Thioredoxin domain-containing protein 222 66.475 Strong candidate 0.6234 ProteomeLM contextual shift 0.12070712 1.0 26 1.0 465 2 0.6226 0.8055 80.55 0.08 1.0 oxidoreductase, reductase ProteomeLM contextual percentile 0.62; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: oxidoreductase, reductase /main_page_ml/ML2412 2026-05-30T13:09:52Z 742 ML1816 Q9CBL2 ML1816 ABC transporter ATP-binding protein, possibly in EF-3 subfamily 545 66.459 Strong candidate 0.6685 ProteomeLM contextual shift 0.12913904 1.0 123 1.0 1659 48 0.8948 0.7835 78.35 0.08 0.8625 ProteomeLM contextual percentile 0.67; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML1816 2026-05-30T13:09:52Z 743 ML0730 Q7AQF7 ML0730 ML0730 protein 84 66.44 Strong candidate 0.7964 ProteomeLM contextual shift 0.16830805 1.0 12 1.0 275 46 0.7897 0.4392 43.92 0.08 0.7575 ProteomeLM contextual percentile 0.80; strong pocket/AF2Bind evidence /main_page_ml/ML0730 2026-05-30T13:09:52Z 744 ML0285 Q7AQK2 ML0285 Membrane protein 292 66.422 Strong candidate 0.7914 ProteomeLM contextual shift 0.1656335 1.0 40 1.0 885 18 0.898 0.51 51.0 0.0 0.8625 ProteomeLM contextual percentile 0.79; strong pocket/AF2Bind evidence /main_page_ml/ML0285 2026-05-30T13:09:52Z 745 ML1849 O32993 rplN ML1849 MLCB2492.14 Large ribosomal subunit protein uL14 (50S ribosomal protein L14) 122 66.421 Strong candidate 0.5439 ProteomeLM contextual shift 0.10822345 1.0 16 1.0 395 112 0.9092 0.9461 94.61 0.215 0.8625 translation, ribosome, ribosomal ProteomeLM contextual percentile 0.54; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: translation, ribosome, ribosomal /main_page_ml/ML1849 2026-05-30T13:09:52Z 746 ML0662 Q7AQG7 ML0662 Histidinol-phosphatase (EC 3.1.3.15) 255 66.421 Strong candidate 0.2632 ProteomeLM contextual shift 0.074645475 1.0 54 1.0 794 58 0.9082 0.9411 94.11 0.64 1.0 3.1.3.15 PATHWAY: Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 8/9. {ECO:0000256|ARBA:ARBA00004970}. cofactor ProteomeLM contextual percentile 0.26; strong pocket/AF2Bind evidence; essential-process annotation; high-confidence Boltz2 model; matched: cofactor /main_page_ml/ML0662 2026-05-30T13:09:52Z 747 ML2257 Q9CBB8 menE ML2257 O-succinylbenzoic acid-CoA ligase 368 66.42 Strong candidate 0.5959 ProteomeLM contextual shift 0.11668752 1.0 66 1.0 1207 206 0.9841 0.8964 89.64 0.08 1.0 ligase ProteomeLM contextual percentile 0.60; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: ligase /main_page_ml/ML2257 2026-05-30T13:09:52Z 748 ML1892 P30769 mkl ML1892 Probable ribonucleotide transport ATP-binding protein mkl 347 66.417 Strong candidate 0.5677 ProteomeLM contextual shift 0.11178429 1.0 34 1.0 1038 48 0.8096 0.8923 89.23 0.2 0.8625 ProteomeLM contextual percentile 0.57; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML1892 2026-05-30T13:09:52Z 749 ML0814 Q9CCH1 ML0814 ATP-binding protein 82 66.407 Strong candidate 0.75 ProteomeLM contextual shift 0.14971681 1.0 106 1.0 291 90 0.8784 0.7582 75.82 0.0 0.7575 ProteomeLM contextual percentile 0.75; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML0814 2026-05-30T13:09:52Z 750 ML0732 Q9CCL3 birA ML0732 biotin--[biotin carboxyl-carrier protein] ligase (EC 6.3.4.15) 274 66.407 Strong candidate 0.5044 ProteomeLM contextual shift 0.1034956 1.0 42 1.0 883 122 0.9495 0.8954 89.54 0.24 1.0 6.3.4.15 ligase ProteomeLM contextual percentile 0.50; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: ligase /main_page_ml/ML0732 2026-05-30T13:09:52Z 751 ML2140 O33060 ML2140 MLCB57.31 Uncharacterized HTH-type transcriptional regulator ML2140 143 66.401 Strong candidate 0.6128 ProteomeLM contextual shift 0.11885821 1.0 20 1.0 460 62 0.9793 0.8829 88.29 0.125 0.8625 transcription ProteomeLM contextual percentile 0.61; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: transcription /main_page_ml/ML2140 2026-05-30T13:09:52Z 752 ML1600 Q9CBU0 xerC ML1600 MLCB250.62 Tyrosine recombinase XerC 297 66.379 Strong candidate 0.562 ProteomeLM contextual shift 0.110905446 1.0 40 1.0 624 60 0.9392 0.8183 81.83 0.245 0.8625 cell division ProteomeLM contextual percentile 0.56; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: cell division /main_page_ml/ML1600 2026-05-30T13:09:52Z 753 ML0818 Q9CCG7 ML0818 Aminoglycoside phosphotransferase domain-containing protein 297 66.364 Strong candidate 0.636 ProteomeLM contextual shift 0.12224535 1.0 38 1.0 949 116 0.9873 0.9105 91.05 0.0 1.0 transferase ProteomeLM contextual percentile 0.64; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: transferase /main_page_ml/ML0818 2026-05-30T13:09:52Z 754 ML1526 Q9CBV7 ML1526 Conserved membrane protein 160 66.349 Strong candidate 0.7105 ProteomeLM contextual shift 0.1398827 1.0 16 1.0 520 80 0.8888 0.7856 78.56 0.0 0.8625 ProteomeLM contextual percentile 0.71; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML1526 2026-05-30T13:09:52Z 755 ML0193 Q9CD60 rsmI ML0193 Ribosomal RNA small subunit methyltransferase I (EC 2.1.1.198) (16S rRNA 2'-O-ribose C1402 methyltransferase) (rRNA (cytidine-2'-O-)-methyltransferase RsmI) 281 66.335 Strong candidate 0.4148 ProteomeLM contextual shift 0.093781255 1.0 38 1.0 890 94 0.9739 0.8717 87.17 0.405 1.0 2.1.1.198 ribosomal, transferase ProteomeLM contextual percentile 0.41; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model; matched: ribosomal, transferase /main_page_ml/ML0193 2026-05-30T13:09:52Z 756 ML0733 Q9CCL2 ML0733 Membrane protein 172 66.332 Strong candidate 0.6961 ProteomeLM contextual shift 0.13586462 1.0 20 1.0 533 34 0.8356 0.8343 83.43 0.0 0.8625 ProteomeLM contextual percentile 0.70; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML0733 2026-05-30T13:09:52Z 757 ML1726 Q9CBQ7 ML1726 ABC transporter protein, ATP-binding component 305 66.312 Strong candidate 0.6516 ProteomeLM contextual shift 0.12537599 1.0 56 1.0 617 14 0.8089 0.828 82.8 0.08 0.8625 ProteomeLM contextual percentile 0.65; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML1726 2026-05-30T13:09:52Z 758 ML1667 Q9CBS4 ML1667 Possible conserved membrane protein 264 66.287 Strong candidate 0.718 ProteomeLM contextual shift 0.14154616 1.0 51 1.0 820 16 0.7547 0.753 75.3 0.0 0.8625 ProteomeLM contextual percentile 0.72; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML1667 2026-05-30T13:09:52Z 759 ML2598 Q9CD05 ML2598 Secreted protein 184 66.249 Strong candidate 0.6617 ProteomeLM contextual shift 0.12770684 1.0 38 1.0 592 80 0.9767 0.7866 78.66 0.08 0.8625 ProteomeLM contextual percentile 0.66; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML2598 2026-05-30T13:09:52Z 760 ML2605 Q7APT5 ML2605 TIGR04338 family metallohydrolase 168 66.242 Strong candidate 0.6391 ProteomeLM contextual shift 0.12295112 1.0 18 1.0 515 22 0.7422 0.8873 88.73 0.0 1.0 hydrolase ProteomeLM contextual percentile 0.64; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: hydrolase /main_page_ml/ML2605 2026-05-30T13:09:52Z 761 ML0178 Q9Z5G4 mscL ML0178 MLCB373.30c Large-conductance mechanosensitive channel 154 66.23 Strong candidate 0.74 ProteomeLM contextual shift 0.14680438 1.0 74 1.0 483 42 0.8786 0.5106 51.06 0.08 0.8625 ProteomeLM contextual percentile 0.74; strong pocket/AF2Bind evidence /main_page_ml/ML0178 2026-05-30T13:09:52Z 762 ML0204 Q7AQM0 rmlB2 ML0204 Sugar-nucleotide dehydratase 319 66.225 Strong candidate 0.6353 ProteomeLM contextual shift 0.12222725 1.0 104 1.0 1071 228 0.9926 0.9463 94.63 0.045 0.8625 nad ProteomeLM contextual percentile 0.64; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: nad /main_page_ml/ML0204 2026-05-30T13:09:52Z 763 ML1800 Q9CBM6 mutA ML1800 Methylmalonyl-CoA mutase small subunit (EC 5.4.99.2) 636 66.225 Strong candidate 0.3321 ProteomeLM contextual shift 0.082916856 1.0 78 1.0 1911 6 0.6087 0.9202 92.02 0.52 1.0 5.4.99.2 PATHWAY: Metabolic intermediate metabolism; propanoyl-CoA degradation; succinyl-CoA from propanoyl-CoA: step 3/3. {ECO:0000256|ARBA:ARBA00005146}. cofactor ProteomeLM contextual percentile 0.33; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model; matched: cofactor /main_page_ml/ML1800 2026-05-30T13:09:52Z 764 ML0383 Q9CCV3 ML0383 Uncharacterized protein 281 66.21 Strong candidate 0.6711 ProteomeLM contextual shift 0.12955907 1.0 50 1.0 616 108 0.9829 0.9098 90.98 0.0 0.8625 ProteomeLM contextual percentile 0.67; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML0383 2026-05-30T13:09:52Z 765 ML2028 P31951 fbpB ML2028 MLCB561.03c Diacylglycerol acyltransferase/mycolyltransferase Ag85B (DGAT) (EC 2.3.1.122) (EC 2.3.1.20) (30 kDa extracellular protein) (Acyl-CoA:diacylglycerol acyltransferase) (Antigen 85 complex B) (85B) (Ag85B) (Extracellular alpha-antigen) (Fibronectin-binding protein B) (Fbps B) 327 66.209 Strong candidate 0.3628 ProteomeLM contextual shift 0.0877717 1.0 56 1.0 1002 42 0.9597 0.8911 89.11 0.48 1.0 2.3.1.122; 2.3.1.20 transferase ProteomeLM contextual percentile 0.36; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model; matched: transferase /main_page_ml/ML2028 2026-05-30T13:09:52Z 766 ML1750 Q9CBP6 ML1750 Uncharacterized protein 623 66.2 Strong candidate 0.7086 ProteomeLM contextual shift 0.1395789 1.0 106 1.0 1874 10 0.6043 0.7772 77.72 0.0 0.8625 ProteomeLM contextual percentile 0.71; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML1750 2026-05-30T13:09:52Z 767 ML2684 P46390 ssb ML2684 MLCB1913.20c Single-stranded DNA-binding protein (SSB) 168 66.194 Strong candidate 0.6479 ProteomeLM contextual shift 0.12444777 1.0 28 1.0 365 58 0.9646 0.6494 64.94 0.17 0.8625 dna replication, replication ProteomeLM contextual percentile 0.65; strong pocket/AF2Bind evidence; matched: dna replication, replication /main_page_ml/ML2684 2026-05-30T13:09:52Z 768 ML2309 Q9CB84 ML2309 Calcineurin-like phosphoesterase domain-containing protein 330 66.188 Strong candidate 0.6021 ProteomeLM contextual shift 0.11747452 1.0 52 1.0 1031 82 0.9018 0.8514 85.14 0.08 1.0 hydrolase ProteomeLM contextual percentile 0.60; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: hydrolase /main_page_ml/ML2309 2026-05-30T13:09:52Z 769 ML1207 Q9X7F0 dnaE ML1207 MLCB458.21 DNA polymerase III subunit alpha (EC 2.7.7.7) 1177 66.176 Strong candidate 0.4073 ProteomeLM contextual shift 0.09306002 1.0 158 1.0 3591 0 0.4412 0.8672 86.72 0.45 0.925 2.7.7.7 dna replication, replication ProteomeLM contextual percentile 0.41; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model; matched: dna replication, replication /main_page_ml/ML1207 2026-05-30T13:09:52Z 770 ML0081 Q9CDC2 ML0081 Membrane protein 450 66.155 Strong candidate 0.7513 ProteomeLM contextual shift 0.14997575 1.0 42 1.0 1355 10 0.6008 0.6236 62.36 0.0 0.8625 ProteomeLM contextual percentile 0.75; strong pocket/AF2Bind evidence /main_page_ml/ML0081 2026-05-30T13:09:52Z 771 ML2661 Q9CCY8 ML2661 Acyl-CoA synthase 548 66.152 Strong candidate 0.5984 ProteomeLM contextual shift 0.116997465 1.0 80 1.0 1121 50 0.8761 0.8609 86.09 0.08 1.0 enzyme, ligase, synthase ProteomeLM contextual percentile 0.60; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: enzyme, ligase, synthase /main_page_ml/ML2661 2026-05-30T13:09:52Z 772 ML2271 Q9CBA9 ML2271 Membrane protein 175 66.137 Strong candidate 0.7099 ProteomeLM contextual shift 0.139692 1.0 20 1.0 555 60 0.9711 0.7666 76.66 0.0 0.8625 ProteomeLM contextual percentile 0.71; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML2271 2026-05-30T13:09:52Z 773 ML0180 Q9CD66 ML0180 Putative regulatory protein FmdB zinc ribbon domain-containing protein 99 66.13 Strong candidate 0.8039 ProteomeLM contextual shift 0.17071831 1.0 10 1.0 328 62 0.9114 0.5419 54.19 0.0 0.7575 ProteomeLM contextual percentile 0.80; strong pocket/AF2Bind evidence /main_page_ml/ML0180 2026-05-30T13:09:52Z 774 ML0022 Q9CDE4 ML0022 FHA domain-containing protein 488 66.124 Strong candidate 0.8076 ProteomeLM contextual shift 0.17155293 1.0 42 1.0 1509 50 0.7927 0.4232 42.32 0.0 0.8625 ProteomeLM contextual percentile 0.81; strong pocket/AF2Bind evidence /main_page_ml/ML0022 2026-05-30T13:09:52Z 775 ML1591 O33045 pyrH ML1591 MLCB250.75 Uridylate kinase (UK) (EC 2.7.4.22) (Uridine monophosphate kinase) (UMP kinase) (UMPK) 255 66.123 Strong candidate 0.292 ProteomeLM contextual shift 0.078448646 1.0 173 1.0 892 110 0.9603 0.8103 81.03 0.64 1.0 2.7.4.22 PATHWAY: Pyrimidine metabolism; CTP biosynthesis via de novo pathway; UDP from UMP (UMPK route): step 1/1. {ECO:0000255|HAMAP-Rule:MF_01220}. kinase ProteomeLM contextual percentile 0.29; strong pocket/AF2Bind evidence; essential-process annotation; high-confidence Boltz2 model; matched: kinase /main_page_ml/ML1591 2026-05-30T13:09:52Z 776 ML0910 O69556 murF ML0910 MLCB268.06c UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase (EC 6.3.2.10) (D-alanyl-D-alanine-adding enzyme) (UDP-MurNAc-pentapeptide synthetase) 517 66.111 Strong candidate 0.1472 ProteomeLM contextual shift 0.05902964 1.0 50 1.0 1588 74 0.9058 0.8657 86.57 0.865 1.0 6.3.2.10 PATHWAY: Cell wall biogenesis; peptidoglycan biosynthesis. {ECO:0000255|HAMAP-Rule:MF_02019}. cell division, peptidoglycan, cell wall, mur, enzyme, ligase, synthetase ProteomeLM contextual percentile 0.15; strong pocket/AF2Bind evidence; essential-process annotation; high-confidence Boltz2 model; matched: cell division, peptidoglycan, cell wall, mur, enzyme /main_page_ml/ML0910 2026-05-30T13:09:52Z 777 ML2307 Q9CB86 whiB ML2307 Transcriptional regulator WhiB 81 66.063 Strong candidate 0.5257 ProteomeLM contextual shift 0.10594544 1.0 15 1.0 281 76 0.9477 0.7914 79.14 0.29 0.895 transcription, nad, reductase, cofactor ProteomeLM contextual percentile 0.53; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: transcription, nad, reductase, cofactor /main_page_ml/ML2307 2026-05-30T13:09:52Z 778 ML1676 Q9CBS2 thiL ML1676 Thiamine-monophosphate kinase (TMP kinase) (Thiamine-phosphate kinase) (EC 2.7.4.16) 325 66.061 Strong candidate 0.2387 ProteomeLM contextual shift 0.070923954 1.0 46 1.0 670 40 0.9545 0.9006 90.06 0.685 1.0 2.7.4.16 PATHWAY: Cofactor biosynthesis; thiamine diphosphate biosynthesis; thiamine diphosphate from thiamine phosphate: step 1/1. {ECO:0000256|HAMAP-Rule:MF_02128}. cofactor biosynthesis, kinase, cofactor ProteomeLM contextual percentile 0.24; strong pocket/AF2Bind evidence; essential-process annotation; high-confidence Boltz2 model; matched: cofactor biosynthesis, kinase, cofactor /main_page_ml/ML1676 2026-05-30T13:09:52Z 779 ML1954 Q9X795 coaA ML1954 MLCB1222.23 Pantothenate kinase (EC 2.7.1.33) (Pantothenic acid kinase) 312 66.055 Strong candidate 0.2362 ProteomeLM contextual shift 0.07054678 1.0 90 1.0 1018 164 0.9929 0.9087 90.87 0.685 1.0 2.7.1.33 PATHWAY: Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 1/5. cofactor biosynthesis, enzyme, kinase, cofactor ProteomeLM contextual percentile 0.24; strong pocket/AF2Bind evidence; essential-process annotation; high-confidence Boltz2 model; matched: cofactor biosynthesis, enzyme, kinase, cofactor /main_page_ml/ML1954 2026-05-30T13:09:52Z 780 ML1167 P53425 ML1167 B1549_C2_208 Uncharacterized aminopeptidase ML1167 (EC 3.4.11.-) 362 66.045 Strong candidate 0.4919 ProteomeLM contextual shift 0.102049686 1.0 76 1.0 1094 16 0.6377 0.903 90.3 0.24 1.0 3.4.11.- ProteomeLM contextual percentile 0.49; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML1167 2026-05-30T13:09:52Z 781 ML0875 Q9CCF1 ctaC ML0875 Probable cytochrome c oxidase subunit 2 (EC 7.1.1.9) (Cytochrome aa3 subunit 2) (Cytochrome c oxidase polypeptide II) 353 66.032 Strong candidate 0.3728 ProteomeLM contextual shift 0.08891819 1.0 26 1.0 746 0 0.4302 0.8384 83.84 0.48 1.0 7.1.1.9 cofactor ProteomeLM contextual percentile 0.37; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model; matched: cofactor /main_page_ml/ML0875 2026-05-30T13:09:52Z 782 ML2573 O69497 gabD1 ML2573 MLCB1883.11c Succinate-semialdehyde dehydrogenase [NADP(+)] (SSADH) (SSDH) (EC 1.2.1.79) 457 66.028 Strong candidate 0.3083 ProteomeLM contextual shift 0.08000587 1.0 72 1.0 1411 80 0.8021 0.9739 97.39 0.525 1.0 1.2.1.79 nad, dehydrogenase ProteomeLM contextual percentile 0.31; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model; matched: nad, dehydrogenase /main_page_ml/ML2573 2026-05-30T13:09:52Z 783 ML1560 Q7AQ42 ML1560 Uncharacterized protein 178 66.027 Strong candidate 0.7312 ProteomeLM contextual shift 0.1453693 1.0 16 1.0 576 84 0.9439 0.681 68.1 0.0 0.8625 ProteomeLM contextual percentile 0.73; strong pocket/AF2Bind evidence /main_page_ml/ML1560 2026-05-30T13:09:52Z 784 ML1410 Q9CC11 argF ML1410 Ornithine carbamoyltransferase (OTCase) (EC 2.1.3.3) 306 66.019 Strong candidate 0.2569 ProteomeLM contextual shift 0.074190274 1.0 84 1.0 1008 96 0.879 0.9228 92.28 0.64 1.0 2.1.3.3 PATHWAY: Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 1/3. {ECO:0000255|HAMAP-Rule:MF_01109}. transferase ProteomeLM contextual percentile 0.26; strong pocket/AF2Bind evidence; essential-process annotation; high-confidence Boltz2 model; matched: transferase /main_page_ml/ML1410 2026-05-30T13:09:52Z 785 ML2031 Q9CBF7 ML2031 Cyclase 151 66.001 Strong candidate 0.6692 ProteomeLM contextual shift 0.12925026 1.0 22 1.0 512 118 0.9731 0.8955 89.55 0.0 0.8625 ProteomeLM contextual percentile 0.67; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML2031 2026-05-30T13:09:52Z 786 ML1423 Q7AQ55 ML1423 PNPLA domain-containing protein 329 66.001 Strong candidate 0.537 ProteomeLM contextual shift 0.107442535 1.0 60 1.0 1065 156 0.9901 0.8207 82.07 0.2 1.0 hydrolase ProteomeLM contextual percentile 0.54; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: hydrolase /main_page_ml/ML1423 2026-05-30T13:09:52Z 787 ML2203 Q9CBC4 ML2203 Uncharacterized protein 373 65.966 Strong candidate 0.6197 ProteomeLM contextual shift 0.11988625 1.0 40 1.0 764 36 0.9181 0.9052 90.52 0.08 0.8625 ProteomeLM contextual percentile 0.62; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML2203 2026-05-30T13:09:52Z 788 ML0279 Q7AQK5 ML0279 Acyl-coenzyme A thioesterase THEM4 (EC 3.1.2.2) (Thioesterase superfamily member 4) 218 65.966 Strong candidate 0.4305 ProteomeLM contextual shift 0.0953726 1.0 53 1.0 493 114 0.9929 0.87 87.0 0.36 1.0 3.1.2.2 enzyme, hydrolase ProteomeLM contextual percentile 0.43; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model; matched: enzyme, hydrolase /main_page_ml/ML0279 2026-05-30T13:09:52Z 789 ML2616 Q7APT0 ML2616 Uncharacterized protein 170 65.959 Strong candidate 0.6491 ProteomeLM contextual shift 0.12465531 1.0 12 1.0 362 4 0.7144 0.8014 80.14 0.08 0.8625 ProteomeLM contextual percentile 0.65; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML2616 2026-05-30T13:09:52Z 790 ML1467 Q9CBZ2 rplU ML1467 Large ribosomal subunit protein bL21 (50S ribosomal protein L21) 103 65.937 Strong candidate 0.5796 ProteomeLM contextual shift 0.1143382 1.0 10 1.0 318 18 0.7647 0.8777 87.77 0.215 0.7575 translation, ribosome, ribosomal ProteomeLM contextual percentile 0.58; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: translation, ribosome, ribosomal /main_page_ml/ML1467 2026-05-30T13:09:52Z 791 ML2549 Q9CD26 ML2549 Carboxyltransferase domain-containing protein 222 65.934 Strong candidate 0.5996 ProteomeLM contextual shift 0.11716098 1.0 26 1.0 453 18 0.7827 0.8347 83.47 0.08 1.0 transferase, hydrolase ProteomeLM contextual percentile 0.60; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: transferase, hydrolase /main_page_ml/ML2549 2026-05-30T13:09:52Z 792 ML0637 P53528 uvrD2 ML0637 B1937_F1_27 ATP-dependent DNA helicase UvrD2 (EC 5.6.2.4) (DNA 3'-5' helicase UvrD2) 714 65.933 Strong candidate 0.3784 ProteomeLM contextual shift 0.089829504 1.0 126 1.0 1440 12 0.8806 0.8087 80.87 0.48 1.0 5.6.2.4 cofactor ProteomeLM contextual percentile 0.38; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model; matched: cofactor /main_page_ml/ML0637 2026-05-30T13:09:52Z 793 ML2636 Q9CCZ6 pntAA ML2636 NAD(P) transhydrogenase subunit alpha part 1 (EC 7.1.1.1) (Nicotinamide nucleotide transhydrogenase subunit alpha 1) (Pyridine nucleotide transhydrogenase subunit alpha 1) 367 65.924 Strong candidate 0.3891 ProteomeLM contextual shift 0.09136435 1.0 30 1.0 1166 130 0.9736 0.9206 92.06 0.405 1.0 7.1.1.1 nad ProteomeLM contextual percentile 0.39; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model; matched: nad /main_page_ml/ML2636 2026-05-30T13:09:52Z 794 ML2439 P54884 rgx3 ML2439 B2168_C3_248 Sensory transduction protein RegX3 198 65.92 Strong candidate 0.6642 ProteomeLM contextual shift 0.12816018 1.0 74 1.0 659 130 0.9951 0.6549 65.49 0.125 0.8625 transcription ProteomeLM contextual percentile 0.66; strong pocket/AF2Bind evidence; matched: transcription /main_page_ml/ML2439 2026-05-30T13:09:52Z 795 ML0889 Q7AQE0 ML0889 Coenzyme Q-binding protein COQ10 START domain-containing protein 144 65.898 Strong candidate 0.6184 ProteomeLM contextual shift 0.119587675 1.0 20 1.0 446 28 0.9534 0.9254 92.54 0.0 1.0 enzyme ProteomeLM contextual percentile 0.62; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: enzyme /main_page_ml/ML0889 2026-05-30T13:09:52Z 796 ML0255 Q9CD42 eno ML0255 Enolase (EC 4.2.1.11) (2-phospho-D-glycerate hydro-lyase) (2-phosphoglycerate dehydratase) 429 65.88 Strong candidate 0.2538 ProteomeLM contextual shift 0.07347354 1.0 59 1.0 1344 6 0.702 0.9199 91.99 0.64 1.0 4.2.1.11 PATHWAY: Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 4/5. {ECO:0000255|HAMAP-Rule:MF_00318}. lyase, cofactor ProteomeLM contextual percentile 0.25; strong pocket/AF2Bind evidence; essential-process annotation; high-confidence Boltz2 model; matched: lyase, cofactor /main_page_ml/ML0255 2026-05-30T13:09:52Z 797 ML2130 Q7APY8 gltA2 ML2130 Citrate synthase 431 65.877 Strong candidate 0.3465 ProteomeLM contextual shift 0.08560296 1.0 154 1.0 1357 128 0.9597 0.915 91.5 0.48 1.0 PATHWAY: Carbohydrate metabolism; tricarboxylic acid cycle; isocitrate from oxaloacetate: step 1/2. {ECO:0000256|ARBA:ARBA00004751, ECO:0000256|RuleBase:RU003370}. synthase ProteomeLM contextual percentile 0.35; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model; matched: synthase /main_page_ml/ML2130 2026-05-30T13:09:52Z 798 ML1334 Q7AQ65 ML1334 Possible conserved membrane protein 272 65.869 Strong candidate 0.8058 ProteomeLM contextual shift 0.1713848 1.0 26 1.0 857 42 0.8583 0.4042 40.42 0.0 0.8625 ProteomeLM contextual percentile 0.81; strong pocket/AF2Bind evidence /main_page_ml/ML1334 2026-05-30T13:09:52Z 799 ML0128 Q9CD88 ML0128 Glycosyl transferase 435 65.861 Strong candidate 0.5902 ProteomeLM contextual shift 0.11618162 1.0 50 1.0 923 106 0.9649 0.8603 86.03 0.08 1.0 transferase ProteomeLM contextual percentile 0.59; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: transferase /main_page_ml/ML0128 2026-05-30T13:09:52Z 800 ML1221 Q49616 bsaP ML1221 B1170_C1_162 Biotin synthase auxiliary protein 80 65.834 Strong candidate 0.6272 ProteomeLM contextual shift 0.1211206 1.0 20 1.0 288 96 0.9569 0.8332 83.32 0.08 0.895 synthase, cofactor ProteomeLM contextual percentile 0.63; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: synthase, cofactor /main_page_ml/ML1221 2026-05-30T13:09:52Z 801 ML0663 Q7AQG6 ML0663 Uncharacterized protein 104 65.817 Strong candidate 0.7074 ProteomeLM contextual shift 0.13867894 1.0 8 1.0 372 0 0.476 0.8483 84.83 0.0 0.7575 ProteomeLM contextual percentile 0.71; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML0663 2026-05-30T13:09:52Z 802 ML0094 Q9CDB6 ML0094 Membrane protein 192 65.811 Strong candidate 0.5865 ProteomeLM contextual shift 0.11543121 1.0 30 1.0 610 68 0.8524 0.8685 86.85 0.08 1.0 hydrolase ProteomeLM contextual percentile 0.59; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: hydrolase /main_page_ml/ML0094 2026-05-30T13:09:52Z 803 ML0214 O69537 hpt hprT ML0214 Hypoxanthine-guanine phosphoribosyltransferase (HGPRT) (HGPRTase) (EC 2.4.2.8) 203 65.747 Strong candidate 0.2688 ProteomeLM contextual shift 0.07566091 1.0 45 1.0 683 88 0.9583 0.8539 85.39 0.64 1.0 2.4.2.8 PATHWAY: Purine metabolism; IMP biosynthesis via salvage pathway; IMP from hypoxanthine: step 1/1. {ECO:0000250|UniProtKB:P9WHQ9}.; PATHWAY: Purine metabolism; GMP biosynthesis via salvage pathway; GMP from guanine: step 1/1. {ECO:0000250|UniProtKB:P9WHQ9}. transferase, cofactor ProteomeLM contextual percentile 0.27; strong pocket/AF2Bind evidence; essential-process annotation; high-confidence Boltz2 model; matched: transferase, cofactor /main_page_ml/ML0214 2026-05-30T13:09:52Z 804 ML0287 O69601 ML0287 MLCB4.30 Uncharacterized membrane protein ML0287 222 65.743 Strong candidate 0.6566 ProteomeLM contextual shift 0.12683757 1.0 32 1.0 450 12 0.7513 0.7536 75.36 0.08 0.8625 ProteomeLM contextual percentile 0.66; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML0287 2026-05-30T13:09:52Z 805 ML1418 Q9CC07 ML1418 Thioredoxin domain-containing protein 182 65.723 Strong candidate 0.5558 ProteomeLM contextual shift 0.10993855 1.0 10 1.0 551 10 0.6648 0.9671 96.71 0.08 1.0 oxidoreductase, reductase ProteomeLM contextual percentile 0.56; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: oxidoreductase, reductase /main_page_ml/ML1418 2026-05-30T13:09:52Z 806 ML1480 Q9CBY3 clpP1 clpP ML1480 ATP-dependent Clp protease proteolytic subunit 1 (EC 3.4.21.92) (Endopeptidase Clp 1) 200 65.722 Strong candidate 0.3753 ProteomeLM contextual shift 0.089321226 1.0 30 1.0 743 142 0.9599 0.7986 79.86 0.48 1.0 3.4.21.92 protease ProteomeLM contextual percentile 0.38; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model; matched: protease /main_page_ml/ML1480 2026-05-30T13:09:52Z 807 ML0717 Q9CCL4 ML0717 TetR-family transcriptional regulator 223 65.703 Strong candidate 0.6053 ProteomeLM contextual shift 0.11795256 1.0 46 1.0 728 118 0.9711 0.8394 83.94 0.125 0.8625 transcription ProteomeLM contextual percentile 0.61; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: transcription /main_page_ml/ML0717 2026-05-30T13:09:52Z 808 ML0912 P57995 murD ML0912 MLCB268.04c UDP-N-acetylmuramoylalanine--D-glutamate ligase (EC 6.3.2.9) (D-glutamic acid-adding enzyme) (UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase) 490 65.689 Strong candidate 0.1598 ProteomeLM contextual shift 0.061461285 1.0 38 1.0 1526 112 0.9004 0.8697 86.97 0.82 1.0 6.3.2.9 PATHWAY: Cell wall biogenesis; peptidoglycan biosynthesis. cell division, peptidoglycan, cell wall, mur, enzyme, ligase, synthetase ProteomeLM contextual percentile 0.16; strong pocket/AF2Bind evidence; essential-process annotation; high-confidence Boltz2 model; matched: cell division, peptidoglycan, cell wall, mur, enzyme /main_page_ml/ML0912 2026-05-30T13:09:52Z 809 ML0841 P46841 enc mmpI ML0841 MLCB22.45c Type 2A encapsulin shell protein (35 kDa antigen) (Major membrane protein I) (MMPI) 307 65.681 Strong candidate 0.6147 ProteomeLM contextual shift 0.119072706 1.0 22 1.0 619 10 0.6898 0.8943 89.43 0.08 0.8625 ProteomeLM contextual percentile 0.61; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML0841 2026-05-30T13:09:52Z 810 ML0533 Q9CCR4 pyrC ML0533 Dihydroorotase (DHOase) (EC 3.5.2.3) 430 65.665 Strong candidate 0.235 ProteomeLM contextual shift 0.07036887 1.0 38 1.0 1312 44 0.8823 0.9641 96.41 0.64 1.0 3.5.2.3 PATHWAY: Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 3/3. {ECO:0000255|HAMAP-Rule:MF_00220}. hydrolase, cofactor ProteomeLM contextual percentile 0.23; strong pocket/AF2Bind evidence; essential-process annotation; high-confidence Boltz2 model; matched: hydrolase, cofactor /main_page_ml/ML0533 2026-05-30T13:09:52Z 811 ML2226 Q7APX4 ptrB ML2226 Protease II 724 65.652 Strong candidate 0.5721 ProteomeLM contextual shift 0.112658724 1.0 182 1.0 1500 104 0.8855 0.903 90.3 0.08 1.0 protease ProteomeLM contextual percentile 0.57; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: protease /main_page_ml/ML2226 2026-05-30T13:09:52Z 812 ML0878 Q9CCE8 ML0878 Transmembrane protein 212 65.646 Strong candidate 0.7788 ProteomeLM contextual shift 0.16075948 1.0 46 1.0 661 50 0.7619 0.4763 47.63 0.0 0.8625 ProteomeLM contextual percentile 0.78; strong pocket/AF2Bind evidence /main_page_ml/ML0878 2026-05-30T13:09:52Z 813 ML1070 Q7AQ94 ML1070 TetR-family transcriptional regulator 217 65.624 Strong candidate 0.6071 ProteomeLM contextual shift 0.11818648 1.0 50 1.0 718 134 0.9893 0.8249 82.49 0.125 0.8625 transcription ProteomeLM contextual percentile 0.61; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: transcription /main_page_ml/ML1070 2026-05-30T13:09:52Z 814 ML1689 Q7AQ28 ML1689 Possible hydrolase 242 65.62 Strong candidate 0.5652 ProteomeLM contextual shift 0.11111297 1.0 26 1.0 525 82 0.921 0.9239 92.39 0.08 1.0 hydrolase, isomerase ProteomeLM contextual percentile 0.57; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: hydrolase, isomerase /main_page_ml/ML1689 2026-05-30T13:09:52Z 815 ML1910 Q9CBJ6 ML1910 UPF0336 protein ML1910 159 65.602 Strong candidate 0.661 ProteomeLM contextual shift 0.12766656 1.0 32 1.0 503 52 0.8965 0.8841 88.41 0.0 0.8625 ProteomeLM contextual percentile 0.66; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML1910 2026-05-30T13:09:52Z 816 ML0869 Q9CCF6 ML0869 MLCB22.07 Uncharacterized protein ML0869 229 65.588 Strong candidate 0.6341 ProteomeLM contextual shift 0.12211412 1.0 22 1.0 271 46 0.916 0.817 81.7 0.08 0.8625 ProteomeLM contextual percentile 0.63; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML0869 2026-05-30T13:09:52Z 817 ML0995 P46811 miaA ML0995 B2235_C3_232 tRNA dimethylallyltransferase (EC 2.5.1.75) (Dimethylallyl diphosphate:tRNA dimethylallyltransferase) (DMAPP:tRNA dimethylallyltransferase) (DMATase) (Isopentenyl-diphosphate:tRNA isopentenyltransferase) (IPP transferase) (IPPT) (IPTase) 311 65.576 Strong candidate 0.3459 ProteomeLM contextual shift 0.085433155 1.0 62 1.0 1037 208 0.9988 0.8871 88.71 0.48 1.0 2.5.1.75 transferase, cofactor ProteomeLM contextual percentile 0.35; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model; matched: transferase, cofactor /main_page_ml/ML0995 2026-05-30T13:09:52Z 818 ML1165 P53423 clpS ML1165 B1549_C2_207 ATP-dependent Clp protease adapter protein ClpS 108 65.524 Strong candidate 0.6322 ProteomeLM contextual shift 0.12201361 1.0 10 1.0 331 14 0.8882 0.7847 78.47 0.08 0.895 protease ProteomeLM contextual percentile 0.63; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: protease /main_page_ml/ML1165 2026-05-30T13:09:52Z 819 ML1370 O05668 ML1370 MLCB1351.03c u0247g Uncharacterized RNA pseudouridine synthase ML1370 (EC 5.4.99.-) (RNA pseudouridylate synthase) (RNA-uridine isomerase) 256 65.513 Strong candidate 0.3471 ProteomeLM contextual shift 0.08562844 1.0 80 1.0 544 60 0.9725 0.8764 87.64 0.48 1.0 5.4.99.- enzyme, isomerase, synthase ProteomeLM contextual percentile 0.35; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model; matched: enzyme, isomerase, synthase /main_page_ml/ML1370 2026-05-30T13:09:52Z 820 ML0516 Q9CCS6 aroC aroF ML0516 Chorismate synthase (CS) (EC 4.2.3.5) (5-enolpyruvylshikimate-3-phosphate phospholyase) 407 65.513 Strong candidate 0.2155 ProteomeLM contextual shift 0.06784637 1.0 208 1.0 1281 0 0.4909 0.927 92.7 0.685 1.0 4.2.3.5 PATHWAY: Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 7/7. {ECO:0000255|HAMAP-Rule:MF_00300}. nad, lyase, synthase, cofactor ProteomeLM contextual percentile 0.22; strong pocket/AF2Bind evidence; essential-process annotation; high-confidence Boltz2 model; matched: nad, lyase, synthase, cofactor /main_page_ml/ML0516 2026-05-30T13:09:52Z 821 ML1666 Q7AQ31 ML1666 Conserved integral membrane protein 214 65.497 Strong candidate 0.6003 ProteomeLM contextual shift 0.11718195 1.0 66 1.0 683 82 0.9432 0.7888 78.88 0.08 1.0 oxidoreductase, reductase ProteomeLM contextual percentile 0.60; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: oxidoreductase, reductase /main_page_ml/ML1666 2026-05-30T13:09:52Z 822 ML1799 Q9CBM7 mutB ML1799 Probable methylmalonyl-CoA mutase large subunit (EC 5.4.99.2) 758 65.466 Strong candidate 0.4267 ProteomeLM contextual shift 0.095065735 1.0 86 1.0 2338 128 0.9169 0.9082 90.82 0.36 0.925 5.4.99.2 cofactor ProteomeLM contextual percentile 0.43; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model; matched: cofactor /main_page_ml/ML1799 2026-05-30T13:09:52Z 823 ML0297 Q9ZBL2 thiG ML0297 MLCB1450.26 Thiazole synthase (EC 2.8.1.10) 261 65.428 Strong candidate 0.2243 ProteomeLM contextual shift 0.0694353 1.0 44 1.0 845 124 0.9838 0.8877 88.77 0.685 1.0 2.8.1.10 PATHWAY: Cofactor biosynthesis; thiamine diphosphate biosynthesis. {ECO:0000255|HAMAP-Rule:MF_00443}. cofactor biosynthesis, synthase, cofactor ProteomeLM contextual percentile 0.22; strong pocket/AF2Bind evidence; essential-process annotation; high-confidence Boltz2 model; matched: cofactor biosynthesis, synthase, cofactor /main_page_ml/ML0297 2026-05-30T13:09:52Z 824 ML0866 O32954 ilvE ML0866 MLCB22.12c Probable branched-chain-amino-acid aminotransferase (BCAT) (EC 2.6.1.42) 368 65.418 Strong candidate 0.3058 ProteomeLM contextual shift 0.07958254 1.0 70 1.0 1168 128 0.9863 0.9316 93.16 0.52 1.0 2.6.1.42 PATHWAY: Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 4/4.; PATHWAY: Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 4/4.; PATHWAY: Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 4/4. transferase, cofactor ProteomeLM contextual percentile 0.31; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model; matched: transferase, cofactor /main_page_ml/ML0866 2026-05-30T13:09:52Z 825 ML2061 Q7APZ9 ML2061 NADH:ubiquinone reductase (non-electrogenic) (EC 1.6.5.9) 466 65.36 Strong candidate 0.3603 ProteomeLM contextual shift 0.0874152 1.0 122 1.0 1451 106 0.9403 0.875 87.5 0.45 1.0 1.6.5.9 nad, menaquinone, dehydrogenase, reductase, cofactor ProteomeLM contextual percentile 0.36; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model; matched: nad, menaquinone, dehydrogenase, reductase, cofactor /main_page_ml/ML2061 2026-05-30T13:09:52Z 826 ML1241 P53526 echA12 ML1241 B1170_C2_224 MLCB1610.01 Probable enoyl-CoA hydratase echA12 (EC 4.2.1.17) 294 65.359 Strong candidate 0.4248 ProteomeLM contextual shift 0.094988525 1.0 67 1.0 908 52 0.9123 0.829 82.9 0.36 1.0 4.2.1.17 isomerase ProteomeLM contextual percentile 0.42; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model; matched: isomerase /main_page_ml/ML1241 2026-05-30T13:09:52Z 827 ML1761 Q9CBP0 ML1761 Uncharacterized protein 114 65.351 Strong candidate 0.7732 ProteomeLM contextual shift 0.15898369 1.0 20 1.0 398 112 0.9694 0.5715 57.15 0.0 0.7575 ProteomeLM contextual percentile 0.77; strong pocket/AF2Bind evidence /main_page_ml/ML1761 2026-05-30T13:09:52Z 828 ML0919 Q9CCE2 ML0919 Pyridoxal phosphate homeostasis protein (PLP homeostasis protein) 257 65.347 Strong candidate 0.6046 ProteomeLM contextual shift 0.11775473 1.0 37 1.0 838 116 0.9572 0.8959 89.59 0.08 0.8625 ProteomeLM contextual percentile 0.60; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML0919 2026-05-30T13:09:52Z 829 ML2095 Q9CBE5 pstS2 phoS2 ML2095 Phosphate-binding protein PstS 3 (PBP 3) (PstS-3) 369 65.32 Strong candidate 0.5489 ProteomeLM contextual shift 0.10908826 1.0 36 1.0 1119 24 0.7024 0.8484 84.84 0.2 0.8625 ProteomeLM contextual percentile 0.55; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML2095 2026-05-30T13:09:52Z 830 ML0393 Q49741 ML0393 B1620_F3_119 Beta-phosphoglucomutase (Beta-PGM) (EC 5.4.2.6) 261 65.319 Strong candidate 0.3452 ProteomeLM contextual shift 0.08532412 1.0 20 1.0 805 44 0.8869 0.8636 86.36 0.48 1.0 5.4.2.6 hydrolase, cofactor ProteomeLM contextual percentile 0.35; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model; matched: hydrolase, cofactor /main_page_ml/ML0393 2026-05-30T13:09:52Z 831 ML0579 Q49700 pgl devB ML0579 B1496_F1_31 6-phosphogluconolactonase (6PGL) (EC 3.1.1.31) 247 65.317 Strong candidate 0.2951 ProteomeLM contextual shift 0.0787666 1.0 26 1.0 767 52 0.8941 0.9588 95.88 0.52 1.0 3.1.1.31 PATHWAY: Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 2/3. isomerase ProteomeLM contextual percentile 0.30; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model; matched: isomerase /main_page_ml/ML0579 2026-05-30T13:09:52Z 832 ML2038 P43315 bfr bfrA ML2038 Bacterioferritin (BFR) (EC 1.16.3.1) (Major membrane protein II) (MMP-II) 159 65.285 Strong candidate 0.3233 ProteomeLM contextual shift 0.08144533 1.0 380 1.0 491 28 0.8403 0.9369 93.69 0.48 1.0 1.16.3.1 cofactor ProteomeLM contextual percentile 0.32; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model; matched: cofactor /main_page_ml/ML2038 2026-05-30T13:09:52Z 833 ML1383 Q50178 coaE ML1383 o410 Dephospho-CoA kinase (EC 2.7.1.24) (Dephosphocoenzyme A kinase) 410 65.246 Strong candidate 0.2137 ProteomeLM contextual shift 0.06769139 1.0 64 1.0 1288 116 0.9343 0.9068 90.68 0.685 1.0 2.7.1.24 PATHWAY: Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 5/5. {ECO:0000255|HAMAP-Rule:MF_00376}. cofactor biosynthesis, enzyme, kinase, cofactor ProteomeLM contextual percentile 0.21; strong pocket/AF2Bind evidence; essential-process annotation; high-confidence Boltz2 model; matched: cofactor biosynthesis, enzyme, kinase, cofactor /main_page_ml/ML1383 2026-05-30T13:09:52Z 834 ML0670 O32882 ftsX ML0670 MLCB1779.20c Cell division protein FtsX 297 65.231 Strong candidate 0.5789 ProteomeLM contextual shift 0.11409649 1.0 40 1.0 933 4 0.6382 0.7943 79.43 0.17 0.8625 cell division, fts ProteomeLM contextual percentile 0.58; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: cell division, fts /main_page_ml/ML0670 2026-05-30T13:09:52Z 835 ML1557 Q7AQ43 ML1557 YlxR domain-containing protein 106 65.202 Strong candidate 0.7011 ProteomeLM contextual shift 0.13699144 1.0 14 1.0 368 100 0.9874 0.8087 80.87 0.0 0.7575 ProteomeLM contextual percentile 0.70; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML1557 2026-05-30T13:09:52Z 836 ML0834 Q9CCG1 ML0834 Uncharacterized protein 100 65.198 Strong candidate 0.8026 ProteomeLM contextual shift 0.17057037 1.0 10 1.0 365 130 0.9563 0.4531 45.31 0.0 0.7575 ProteomeLM contextual percentile 0.80; strong pocket/AF2Bind evidence /main_page_ml/ML0834 2026-05-30T13:09:52Z 837 ML2299 Q9CB94 ML2299 Nudix hydrolase domain-containing protein 266 65.196 Strong candidate 0.5883 ProteomeLM contextual shift 0.115949176 1.0 38 1.0 878 160 0.992 0.8003 80.03 0.08 1.0 enzyme, hydrolase, cofactor ProteomeLM contextual percentile 0.59; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: enzyme, hydrolase, cofactor /main_page_ml/ML2299 2026-05-30T13:09:52Z 838 ML1424 Q7AQ54 ML1424 Trehalose import ATP-binding protein SugC (Nucleotide-binding domain of SugABC transporter) (SugABC transporter ATPase SugC) 356 65.187 Strong candidate 0.5326 ProteomeLM contextual shift 0.106845215 1.0 54 1.0 1116 96 0.8105 0.8922 89.22 0.2 0.8625 ProteomeLM contextual percentile 0.53; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML1424 2026-05-30T13:09:52Z 839 ML1217 P45487 ML1217 B1170_C2_196 8-amino-7-oxononanoate synthase (AONS) (EC 2.3.1.47) (7-keto-8-amino-pelargonic acid synthase) (7-KAP synthase) (KAPA synthase) (8-amino-7-ketopelargonate synthase) (Alpha-oxoamine synthase) 385 65.18 Strong candidate 0.2024 ProteomeLM contextual shift 0.066681325 1.0 80 1.0 1224 138 0.9214 0.9397 93.97 0.685 1.0 2.3.1.47 PATHWAY: Cofactor biosynthesis; biotin biosynthesis. cofactor biosynthesis, transferase, synthase, cofactor ProteomeLM contextual percentile 0.20; strong pocket/AF2Bind evidence; essential-process annotation; high-confidence Boltz2 model; matched: cofactor biosynthesis, transferase, synthase, cofactor /main_page_ml/ML1217 2026-05-30T13:09:52Z 840 ML1909 Q9CBJ7 ML1909 MaoC-like domain-containing protein 142 65.158 Strong candidate 0.5871 ProteomeLM contextual shift 0.11547428 1.0 16 1.0 449 46 0.8443 0.961 96.1 0.0 1.0 isomerase ProteomeLM contextual percentile 0.59; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: isomerase /main_page_ml/ML1909 2026-05-30T13:09:52Z 841 ML1922 Q9CBI8 ML1922 ABM domain-containing protein 105 65.121 Strong candidate 0.7018 ProteomeLM contextual shift 0.13699523 1.0 36 1.0 274 128 0.9956 0.7985 79.85 0.0 0.7575 ProteomeLM contextual percentile 0.70; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML1922 2026-05-30T13:09:52Z 842 ML1539 Q9CBV2 ML1539 Probable membrane protein 503 65.117 Strong candidate 0.6485 ProteomeLM contextual shift 0.12449489 1.0 64 1.0 1551 4 0.6039 0.7194 71.94 0.08 0.8625 ProteomeLM contextual percentile 0.65; strong pocket/AF2Bind evidence /main_page_ml/ML1539 2026-05-30T13:09:52Z 843 ML0554 Q9CCP9 rpe ML0554 Ribulose-phosphate 3-epimerase (EC 5.1.3.1) 224 65.107 Strong candidate 0.2193 ProteomeLM contextual shift 0.068295285 1.0 47 1.0 702 60 0.8833 0.9632 96.32 0.64 1.0 5.1.3.1 PATHWAY: Carbohydrate degradation. {ECO:0000255|HAMAP-Rule:MF_02227}. cofactor ProteomeLM contextual percentile 0.22; strong pocket/AF2Bind evidence; essential-process annotation; high-confidence Boltz2 model; matched: cofactor /main_page_ml/ML0554 2026-05-30T13:09:52Z 844 ML1096 Q9CC96 ML1096 Membrane protein 224 65.099 Strong candidate 0.703 ProteomeLM contextual shift 0.13736884 1.0 36 1.0 699 54 0.9273 0.6869 68.69 0.0 0.8625 ProteomeLM contextual percentile 0.70; strong pocket/AF2Bind evidence /main_page_ml/ML1096 2026-05-30T13:09:52Z 845 ML0425 Q9CCU6 ML0425 Membrane protein 75 65.066 Strong candidate 0.7137 ProteomeLM contextual shift 0.1405107 1.0 8 1.0 285 0 0.417 0.7513 75.13 0.0 0.7575 ProteomeLM contextual percentile 0.71; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML0425 2026-05-30T13:09:52Z 846 ML1923 Q9CBI7 lpqF ML1923 Probale secreted protein 454 65.063 Strong candidate 0.6034 ProteomeLM contextual shift 0.11756871 1.0 84 1.0 1404 84 0.9579 0.8719 87.19 0.08 0.8625 ProteomeLM contextual percentile 0.60; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML1923 2026-05-30T13:09:52Z 847 ML0484 Q9CCT4 fadD9 car ML0484 Carboxylic acid reductase (CAR) (EC 1.2.1.-) (ATP/NADPH-dependent carboxylic acid reductase) 1188 65.035 Strong candidate 0.3396 ProteomeLM contextual shift 0.084498785 1.0 151 1.0 2416 0 0.3704 0.8399 83.99 0.525 0.925 1.2.1.- nad, enzyme, ligase, oxidoreductase ProteomeLM contextual percentile 0.34; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model; matched: nad, enzyme, ligase, oxidoreductase /main_page_ml/ML0484 2026-05-30T13:09:52Z 848 ML2144 Q7APY3 ML2144 Possible exported protein 162 65.027 Strong candidate 0.6673 ProteomeLM contextual shift 0.1287977 1.0 14 1.0 364 0 0.3395 0.8047 80.47 0.0 0.8625 ProteomeLM contextual percentile 0.67; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML2144 2026-05-30T13:09:52Z 849 ML1122 Q9CC81 ML1122 Oligopeptide transport ATP-binding protein OppD (EC 7.4.2.6) 609 65.022 Strong candidate 0.3935 ProteomeLM contextual shift 0.09198546 1.0 222 1.0 1855 56 0.8097 0.905 90.5 0.36 1.0 7.4.2.6 ProteomeLM contextual percentile 0.39; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model /main_page_ml/ML1122 2026-05-30T13:09:52Z 850 ML2407 Q9CB63 ML2407 Membrane protein 111 65.011 Strong candidate 0.7613 ProteomeLM contextual shift 0.15404357 1.0 8 1.0 342 18 0.8381 0.5791 57.91 0.0 0.7575 ProteomeLM contextual percentile 0.76; strong pocket/AF2Bind evidence /main_page_ml/ML2407 2026-05-30T13:09:52Z 851 ML0883 O69581 trpD ML0883 MLCB268.34c Anthranilate phosphoribosyltransferase (EC 2.4.2.18) 366 64.985 Moderate candidate 0.2312 ProteomeLM contextual shift 0.07014083 1.0 36 1.0 786 108 0.9492 0.9093 90.93 0.64 1.0 2.4.2.18 PATHWAY: Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 2/5. {ECO:0000255|HAMAP-Rule:MF_00211}. transferase, cofactor ProteomeLM contextual percentile 0.23; strong pocket/AF2Bind evidence; essential-process annotation; high-confidence Boltz2 model; matched: transferase, cofactor /main_page_ml/ML0883 2026-05-30T13:09:52Z 852 ML1696 O33112 ilvB ML1696 MLCB637.20 Acetolactate synthase (EC 2.2.1.6) (ALS) (Acetohydroxy-acid synthase) 625 64.974 Moderate candidate 0.2375 ProteomeLM contextual shift 0.07088454 1.0 122 1.0 1882 14 0.8135 0.8862 88.62 0.64 1.0 2.2.1.6 PATHWAY: Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 1/4.; PATHWAY: Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 1/4. enzyme, synthase, cofactor ProteomeLM contextual percentile 0.24; strong pocket/AF2Bind evidence; essential-process annotation; high-confidence Boltz2 model; matched: enzyme, synthase, cofactor /main_page_ml/ML1696 2026-05-30T13:09:52Z 853 ML0671 O32881 smpB ML0671 MLCB1779.19c SsrA-binding protein (Small protein B) 160 64.959 Moderate candidate 0.5608 ProteomeLM contextual shift 0.110487536 1.0 18 1.0 521 2 0.624 0.8307 83.07 0.17 0.8625 translation, ribosome ProteomeLM contextual percentile 0.56; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: translation, ribosome /main_page_ml/ML0671 2026-05-30T13:09:52Z 854 ML0643 Q9CCM7 ML0643 endopeptidase La (EC 3.4.21.53) 340 64.95 Moderate candidate 0.3202 ProteomeLM contextual shift 0.08117168 1.0 38 1.0 1062 84 0.9605 0.9144 91.44 0.48 1.0 3.4.21.53 ProteomeLM contextual percentile 0.32; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model /main_page_ml/ML0643 2026-05-30T13:09:52Z 855 ML0091 P19361 ML0091 28 kDa antigen 236 64.911 Moderate candidate 0.8033 ProteomeLM contextual shift 0.17060965 1.0 18 1.0 740 24 0.8183 0.3172 31.72 0.0 0.8625 ProteomeLM contextual percentile 0.80; strong pocket/AF2Bind evidence /main_page_ml/ML0091 2026-05-30T13:09:52Z 856 ML1803 Q9CBM4 ML1803 NfeD-like C-terminal domain-containing protein 143 64.885 Moderate candidate 0.6122 ProteomeLM contextual shift 0.118852116 1.0 12 1.0 435 12 0.6856 0.8234 82.34 0.08 0.8625 ProteomeLM contextual percentile 0.61; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML1803 2026-05-30T13:09:52Z 857 ML1101 Q9CC93 ML1101 Possible acyltransferase 379 64.86 Moderate candidate 0.5501 ProteomeLM contextual shift 0.10935661 1.0 95 1.0 1195 116 0.9783 0.9006 90.06 0.08 1.0 transferase ProteomeLM contextual percentile 0.55; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: transferase /main_page_ml/ML1101 2026-05-30T13:09:52Z 858 ML2322 Q9CB78 asd ML2322 Aspartate-semialdehyde dehydrogenase (ASA dehydrogenase) (ASADH) (EC 1.2.1.11) (Aspartate-beta-semialdehyde dehydrogenase) 351 64.834 Moderate candidate 0.1942 ProteomeLM contextual shift 0.065534785 1.0 58 1.0 1071 36 0.9147 0.9336 93.36 0.685 1.0 1.2.1.11 PATHWAY: Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 2/4. {ECO:0000256|ARBA:ARBA00005076, ECO:0000256|HAMAP-Rule:MF_02121}.; PATHWAY: Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 2/3. {ECO:0000256|ARBA:ARBA00005021, ECO:0000256|HAMAP-Rule:MF_02121}.; PATHWAY: Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 2/5. {ECO:0000256|ARBA:ARBA00005097, ECO:0000256|HAMAP-Rule:MF_02121}. nad, dehydrogenase ProteomeLM contextual percentile 0.19; strong pocket/AF2Bind evidence; essential-process annotation; high-confidence Boltz2 model; matched: nad, dehydrogenase /main_page_ml/ML2322 2026-05-30T13:09:52Z 859 ML2688 Q9CCY4 ponA ML2688 Penicillin-bonding protein 708 64.799 Moderate candidate 0.4217 ProteomeLM contextual shift 0.09458937 1.0 96 1.0 2184 0 0.3614 0.834 83.4 0.335 1.0 peptidoglycan, mur, d-alanine, transferase ProteomeLM contextual percentile 0.42; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: peptidoglycan, mur, d-alanine, transferase /main_page_ml/ML2688 2026-05-30T13:09:52Z 860 ML0190 Q9CD62 ML0190 Fe2OG dioxygenase domain-containing protein 205 64.794 Moderate candidate 0.5946 ProteomeLM contextual shift 0.11656347 1.0 24 1.0 448 76 0.97 0.8758 87.58 0.08 0.8625 ProteomeLM contextual percentile 0.59; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML0190 2026-05-30T13:09:52Z 861 ML1394 Q9CC22 infC ML1394 Translation initiation factor IF-3 202 64.768 Moderate candidate 0.5896 ProteomeLM contextual shift 0.11616538 1.0 28 1.0 377 14 0.7208 0.7107 71.07 0.17 0.8625 translation, ribosome ProteomeLM contextual percentile 0.59; strong pocket/AF2Bind evidence; matched: translation, ribosome /main_page_ml/ML1394 2026-05-30T13:09:52Z 862 ML1547 Q7AQ45 ML1547 4'-phosphopantetheinyl transferase 227 64.761 Moderate candidate 0.4706 ProteomeLM contextual shift 0.099948645 1.0 44 1.0 706 50 0.9478 0.9292 92.92 0.2 1.0 transferase, synthetase, synthase ProteomeLM contextual percentile 0.47; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: transferase, synthetase, synthase /main_page_ml/ML1547 2026-05-30T13:09:52Z 863 ML0521 Q9CCS1 pepQ ML0521 Cytoplasmic peptidase 376 64.753 Moderate candidate 0.5739 ProteomeLM contextual shift 0.112881936 1.0 68 1.0 1167 78 0.9279 0.9441 94.41 0.08 0.8625 ProteomeLM contextual percentile 0.57; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML0521 2026-05-30T13:09:52Z 864 ML2093 Q50097 pstA phoX1 pstA1 ML2093 Phosphate transport system permease protein PstA 304 64.74 Moderate candidate 0.6153 ProteomeLM contextual shift 0.119164206 1.0 30 1.0 926 28 0.8153 0.798 79.8 0.08 0.8625 ProteomeLM contextual percentile 0.62; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML2093 2026-05-30T13:09:52Z 865 ML0222 Q9CD58 ftsH ML0222 MLCB2548.09c ATP-dependent zinc metalloprotease FtsH (EC 3.4.24.-) 787 64.643 Moderate candidate 0.4455 ProteomeLM contextual shift 0.0973024 1.0 82 1.0 2413 6 0.5972 0.6701 67.01 0.405 0.925 3.4.24.- fts, protease, cofactor ProteomeLM contextual percentile 0.45; strong pocket/AF2Bind evidence; functional annotation support; matched: fts, protease, cofactor /main_page_ml/ML0222 2026-05-30T13:09:52Z 866 ML1088 Q9CCA1 ML1088 Trehalose transport system permease protein SugB 287 64.638 Moderate candidate 0.6209 ProteomeLM contextual shift 0.12033964 1.0 42 1.0 873 24 0.8616 0.7681 76.81 0.08 0.8625 ProteomeLM contextual percentile 0.62; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML1088 2026-05-30T13:09:52Z 867 ML1677 Q9CBS1 ML1677 Possible secreted protein 191 64.625 Moderate candidate 0.6579 ProteomeLM contextual shift 0.12692621 1.0 26 1.0 403 2 0.5799 0.7974 79.74 0.0 0.8625 ProteomeLM contextual percentile 0.66; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML1677 2026-05-30T13:09:52Z 868 ML2258 Q7APW7 ML2258 DUF3349 domain-containing protein 100 64.594 Moderate candidate 0.6836 ProteomeLM contextual shift 0.13100031 1.0 10 1.0 315 30 0.8425 0.8094 80.94 0.0 0.7575 ProteomeLM contextual percentile 0.68; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML2258 2026-05-30T13:09:52Z 869 ML0781 Q9CCI6 ML0781 RCK C-terminal domain-containing protein 160 64.592 Moderate candidate 0.6291 ProteomeLM contextual shift 0.12148778 1.0 36 1.0 507 54 0.9147 0.7349 73.49 0.08 0.8625 ProteomeLM contextual percentile 0.63; strong pocket/AF2Bind evidence /main_page_ml/ML0781 2026-05-30T13:09:52Z 870 ML2485 Q9CB29 ML2485 Possible RNA methyltransferase 182 64.507 Moderate candidate 0.5332 ProteomeLM contextual shift 0.106954165 1.0 44 1.0 592 92 0.9448 0.9245 92.45 0.08 1.0 transferase ProteomeLM contextual percentile 0.53; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: transferase /main_page_ml/ML2485 2026-05-30T13:09:52Z 871 ML1038 Q50000 dxs tktB ML1038 1-deoxy-D-xylulose-5-phosphate synthase (EC 2.2.1.7) (1-deoxyxylulose-5-phosphate synthase) (DXP synthase) (DXPS) 643 64.429 Moderate candidate 0.2256 ProteomeLM contextual shift 0.069695406 1.0 158 1.0 1951 44 0.7985 0.8734 87.34 0.64 1.0 2.2.1.7 PATHWAY: Metabolic intermediate biosynthesis; 1-deoxy-D-xylulose 5-phosphate biosynthesis; 1-deoxy-D-xylulose 5-phosphate from D-glyceraldehyde 3-phosphate and pyruvate: step 1/1. {ECO:0000255|HAMAP-Rule:MF_00315}. synthase, cofactor ProteomeLM contextual percentile 0.23; strong pocket/AF2Bind evidence; essential-process annotation; high-confidence Boltz2 model; matched: synthase, cofactor /main_page_ml/ML1038 2026-05-30T13:09:52Z 872 ML0748 Q9CCL0 ML0748 Uncharacterized protein 92 64.42 Moderate candidate 0.7487 ProteomeLM contextual shift 0.14932509 1.0 8 1.0 291 30 0.9351 0.5639 56.39 0.0 0.7575 ProteomeLM contextual percentile 0.75; strong pocket/AF2Bind evidence /main_page_ml/ML0748 2026-05-30T13:09:52Z 873 ML2167 Q9CBD6 kdc ML2167 Alpha-keto-acid decarboxylase (KDC) (EC 4.1.1.-) 569 64.414 Moderate candidate 0.3684 ProteomeLM contextual shift 0.0885992 1.0 192 1.0 1718 22 0.6862 0.9319 93.19 0.36 1.0 4.1.1.- enzyme, cofactor ProteomeLM contextual percentile 0.37; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model; matched: enzyme, cofactor /main_page_ml/ML2167 2026-05-30T13:09:52Z 874 ML2111 Q50121 ML2111 Transmembrane protein 144 64.394 Moderate candidate 0.6259 ProteomeLM contextual shift 0.12104476 1.0 16 1.0 292 8 0.6866 0.8861 88.61 0.0 0.8625 ProteomeLM contextual percentile 0.63; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML2111 2026-05-30T13:09:52Z 875 ML1736 Q9CBP8 nrdH ML1736 Glutaredoxin-like protein NrdH 80 64.387 Moderate candidate 0.599 ProteomeLM contextual shift 0.11705228 1.0 8 1.0 247 14 0.7141 0.9248 92.48 0.08 0.7575 ProteomeLM contextual percentile 0.60; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML1736 2026-05-30T13:09:52Z 876 ML1441 Q7AQ49 lnt ML1441 Apolipoprotein N-acyltransferase (ALP N-acyltransferase) (EC 2.3.1.269) 644 64.343 Moderate candidate 0.3183 ProteomeLM contextual shift 0.08106625 1.0 112 1.0 1959 14 0.866 0.7803 78.03 0.52 1.0 2.3.1.269 PATHWAY: Protein modification; lipoprotein biosynthesis (N-acyl transfer). {ECO:0000256|HAMAP-Rule:MF_01148}. transferase, hydrolase ProteomeLM contextual percentile 0.32; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model; matched: transferase, hydrolase /main_page_ml/ML1441 2026-05-30T13:09:52Z 877 ML0252 Q9CD43 mfd ML0252 Transcription-repair-coupling factor (TRCF) (EC 3.6.4.-) 1224 64.33 Moderate candidate 0.4881 ProteomeLM contextual shift 0.10172481 1.0 196 1.0 1244 0 0.2045 0.8197 81.97 0.285 0.835 3.6.4.- transcription, hydrolase ProteomeLM contextual percentile 0.49; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: transcription, hydrolase /main_page_ml/ML0252 2026-05-30T13:09:52Z 878 ML1227 P46714 nadC ML1227 B1170_C1_168 Nicotinate-nucleotide pyrophosphorylase [carboxylating] (EC 2.4.2.19) (Quinolinate phosphoribosyltransferase [decarboxylating]) (QAPRTase) 284 64.276 Moderate candidate 0.1516 ProteomeLM contextual shift 0.059514787 1.0 60 1.0 586 28 0.7275 0.9369 93.69 0.73 1.0 2.4.2.19 PATHWAY: Cofactor biosynthesis; NAD(+) biosynthesis; nicotinate D-ribonucleotide from quinolinate: step 1/1. nad, cofactor biosynthesis, transferase, cofactor ProteomeLM contextual percentile 0.15; strong pocket/AF2Bind evidence; essential-process annotation; high-confidence Boltz2 model; matched: nad, cofactor biosynthesis, transferase, cofactor /main_page_ml/ML1227 2026-05-30T13:09:52Z 879 ML2015 Q9X7D6 cinA ML2015 MLCB561.17 CinA-like protein 428 64.269 Moderate candidate 0.6303 ProteomeLM contextual shift 0.12177276 1.0 67 1.0 1301 10 0.6679 0.8583 85.83 0.0 0.8625 ProteomeLM contextual percentile 0.63; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML2015 2026-05-30T13:09:52Z 880 ML2503 Q9CB18 rfbA ML2503 Glucose-1-phosphate thymidylyltransferase (EC 2.7.7.24) 288 64.269 Moderate candidate 0.2744 ProteomeLM contextual shift 0.07640039 1.0 142 1.0 869 10 0.6047 0.9264 92.64 0.52 1.0 2.7.7.24 PATHWAY: Carbohydrate biosynthesis; dTDP-L-rhamnose biosynthesis. {ECO:0000256|ARBA:ARBA00004781}. transferase, cofactor ProteomeLM contextual percentile 0.27; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model; matched: transferase, cofactor /main_page_ml/ML2503 2026-05-30T13:09:52Z 881 ML1635 Q9CBT0 panB ML1635 3-methyl-2-oxobutanoate hydroxymethyltransferase (EC 2.1.2.11) (Ketopantoate hydroxymethyltransferase) (KPHMT) 286 64.232 Moderate candidate 0.1667 ProteomeLM contextual shift 0.06257758 1.0 162 1.0 915 114 0.9893 0.8799 87.99 0.73 1.0 2.1.2.11 PATHWAY: Cofactor biosynthesis; (R)-pantothenate biosynthesis; (R)-pantoate from 3-methyl-2-oxobutanoate: step 1/2. {ECO:0000255|HAMAP-Rule:MF_00156}. folate, cofactor biosynthesis, transferase, cofactor ProteomeLM contextual percentile 0.17; strong pocket/AF2Bind evidence; essential-process annotation; high-confidence Boltz2 model; matched: folate, cofactor biosynthesis, transferase, cofactor /main_page_ml/ML1635 2026-05-30T13:09:52Z 882 ML1077 Q9CCA5 ML1077 RNA polymerase subunit sigma-70 139 64.224 Moderate candidate 0.698 ProteomeLM contextual shift 0.13611636 1.0 16 1.0 309 62 0.9115 0.5269 52.69 0.045 0.8625 rna polymerase ProteomeLM contextual percentile 0.70; strong pocket/AF2Bind evidence; matched: rna polymerase /main_page_ml/ML1077 2026-05-30T13:09:52Z 883 ML0815 Q9CCH0 ML0815 TetR-family transcriptional regulator 228 64.221 Moderate candidate 0.5658 ProteomeLM contextual shift 0.111303076 1.0 72 1.0 489 66 0.8721 0.8293 82.93 0.125 0.8625 transcription ProteomeLM contextual percentile 0.57; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: transcription /main_page_ml/ML0815 2026-05-30T13:09:52Z 884 ML0087 Q9CDC0 ML0087 Acyltransferase 257 64.215 Moderate candidate 0.5232 ProteomeLM contextual shift 0.10544814 1.0 38 1.0 889 236 0.985 0.9304 93.04 0.08 1.0 transferase ProteomeLM contextual percentile 0.52; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: transferase /main_page_ml/ML0087 2026-05-30T13:09:52Z 885 ML1953 Q9X794 glyA ML1953 MLCB1222.22 Serine hydroxymethyltransferase (SHMT) (Serine methylase) (EC 2.1.2.1) 426 64.203 Moderate candidate 0.1698 ProteomeLM contextual shift 0.06304888 1.0 110 1.0 878 52 0.8336 0.956 95.6 0.685 1.0 2.1.2.1 PATHWAY: One-carbon metabolism; tetrahydrofolate interconversion. {ECO:0000255|HAMAP-Rule:MF_00051}.; PATHWAY: Amino-acid biosynthesis; glycine biosynthesis; glycine from L-serine: step 1/1. {ECO:0000255|HAMAP-Rule:MF_00051}. folate, transferase, cofactor ProteomeLM contextual percentile 0.17; strong pocket/AF2Bind evidence; essential-process annotation; high-confidence Boltz2 model; matched: folate, transferase, cofactor /main_page_ml/ML1953 2026-05-30T13:09:52Z 886 ML0852 Q7AQE9 ribF ML0852 Riboflavin biosynthesis protein [Includes: Riboflavin kinase (EC 2.7.1.26) (Flavokinase); FMN adenylyltransferase (EC 2.7.7.2) (FAD pyrophosphorylase) (FAD synthase)] 331 64.136 Moderate candidate 0.2544 ProteomeLM contextual shift 0.07357502 1.0 44 1.0 1084 182 0.9825 0.8932 89.32 0.565 1.0 2.7.1.26; 2.7.7.2 PATHWAY: Cofactor biosynthesis; FAD biosynthesis; FAD from FMN: step 1/1. {ECO:0000256|ARBA:ARBA00004726, ECO:0000256|PIRNR:PIRNR004491}.; PATHWAY: Cofactor biosynthesis; FMN biosynthesis; FMN from riboflavin (ATP route): step 1/1. {ECO:0000256|ARBA:ARBA00005201, ECO:0000256|PIRNR:PIRNR004491}. cofactor biosynthesis, kinase, transferase, synthase ProteomeLM contextual percentile 0.25; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model; matched: cofactor biosynthesis, kinase, transferase, synthase /main_page_ml/ML0852 2026-05-30T13:09:52Z 887 ML0682 O32874 metXA metA ML0682 MLCB1779.11 Homoserine O-acetyltransferase (HAT) (EC 2.3.1.31) (Homoserine transacetylase) (HTA) 382 64.113 Moderate candidate 0.1955 ProteomeLM contextual shift 0.065565586 1.0 93 1.0 1178 64 0.9216 0.9471 94.71 0.64 1.0 2.3.1.31 PATHWAY: Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; O-acetyl-L-homoserine from L-homoserine: step 1/1. {ECO:0000255|HAMAP-Rule:MF_00296}. transferase, hydrolase ProteomeLM contextual percentile 0.20; strong pocket/AF2Bind evidence; essential-process annotation; high-confidence Boltz2 model; matched: transferase, hydrolase /main_page_ml/ML0682 2026-05-30T13:09:52Z 888 ML1806 Q9CBM1 inhA ML1806 Enoyl-[acyl-carrier-protein] reductase [NADH] (EC 1.3.1.9) 269 64.1 Moderate candidate 0.1197 ProteomeLM contextual shift 0.05263998 1.0 128 1.0 914 214 0.9984 0.9411 94.11 0.775 1.0 1.3.1.9 PATHWAY: Lipid metabolism; mycolic acid biosynthesis. {ECO:0000256|ARBA:ARBA00004796}. mycolic, nad, lipid metabolism, dehydrogenase, reductase ProteomeLM contextual percentile 0.12; strong pocket/AF2Bind evidence; essential-process annotation; high-confidence Boltz2 model; matched: mycolic, nad, lipid metabolism, dehydrogenase, reductase /main_page_ml/ML1806 2026-05-30T13:09:52Z 889 ML1005 Q49844 nrdR ML1005 B2235_C2_209 u2235a Transcriptional repressor NrdR 154 64.076 Moderate candidate 0.505 ProteomeLM contextual shift 0.10351525 1.0 58 1.0 507 90 0.9555 0.8901 89.01 0.125 1.0 transcription, cofactor ProteomeLM contextual percentile 0.51; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: transcription, cofactor /main_page_ml/ML1005 2026-05-30T13:09:52Z 890 ML0515 Q9CCS7 aroE ML0515 Shikimate 5-dehydrogenase 278 64.076 Moderate candidate 0.406 ProteomeLM contextual shift 0.09305524 1.0 32 1.0 894 120 0.9771 0.9165 91.65 0.285 1.0 PATHWAY: Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 4/7. {ECO:0000256|ARBA:ARBA00004871}. nad, dehydrogenase ProteomeLM contextual percentile 0.41; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: nad, dehydrogenase /main_page_ml/ML0515 2026-05-30T13:09:52Z 891 ML2200 Q9CBC6 ML2200 Ferric nitrobindin-like protein 228 64.073 Moderate candidate 0.6253 ProteomeLM contextual shift 0.12097501 1.0 50 1.0 719 70 0.9559 0.8562 85.62 0.0 0.8625 ProteomeLM contextual percentile 0.63; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML2200 2026-05-30T13:09:52Z 892 ML2209 Q50025 cpsY ML2209 MLCB5.32c Exopolysaccharide phosphotransferase CpsY (EC 2.7.-.-) (Stealth protein CpsY) 542 64.063 Moderate candidate 0.4424 ProteomeLM contextual shift 0.09684128 1.0 86 1.0 1105 42 0.8779 0.8781 87.81 0.24 1.0 2.7.-.- transferase ProteomeLM contextual percentile 0.44; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: transferase /main_page_ml/ML2209 2026-05-30T13:09:52Z 893 ML0426 Q9CCU5 lppS ML0426 Secreted protein 404 64.062 Moderate candidate 0.3352 ProteomeLM contextual shift 0.083566464 1.0 48 1.0 1229 34 0.8315 0.8329 83.29 0.45 1.0 PATHWAY: Cell wall biogenesis; peptidoglycan biosynthesis. {ECO:0000256|ARBA:ARBA00004752, ECO:0000256|PROSITE-ProRule:PRU01373}.; PATHWAY: Glycan biosynthesis. {ECO:0000256|ARBA:ARBA00060592}. peptidoglycan, cell wall, transferase ProteomeLM contextual percentile 0.34; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model; matched: peptidoglycan, cell wall, transferase /main_page_ml/ML0426 2026-05-30T13:09:52Z 894 ML1015 Q9CCB4 ML1015 Possible conserved membrane protein 139 64.058 Moderate candidate 0.7387 ProteomeLM contextual shift 0.14618054 1.0 12 1.0 432 30 0.8793 0.4578 45.78 0.0 0.8625 ProteomeLM contextual percentile 0.74; strong pocket/AF2Bind evidence /main_page_ml/ML1015 2026-05-30T13:09:52Z 895 ML2261 Q9CBB6 ML2261 VOC domain-containing protein 138 64.02 Moderate candidate 0.6541 ProteomeLM contextual shift 0.12623131 1.0 22 1.0 498 168 0.9816 0.75 75.0 0.0 0.8625 ProteomeLM contextual percentile 0.65; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML2261 2026-05-30T13:09:52Z 896 ML2687 Q7APR9 ML2687 Conserved membrane protein 564 63.989 Moderate candidate 0.5263 ProteomeLM contextual shift 0.106014974 1.0 102 1.0 1706 28 0.8216 0.8968 89.68 0.08 1.0 transferase ProteomeLM contextual percentile 0.53; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: transferase /main_page_ml/ML2687 2026-05-30T13:09:52Z 897 ML0666 O32886 fprA ML0666 MLCB1779.25 NADPH-ferredoxin reductase FprA (NFR) (EC 1.18.1.2) 456 63.988 Moderate candidate 0.2613 ProteomeLM contextual shift 0.07441613 1.0 59 1.0 1464 192 0.9789 0.9343 93.43 0.525 1.0 1.18.1.2 nad, reductase, cofactor ProteomeLM contextual percentile 0.26; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model; matched: nad, reductase, cofactor /main_page_ml/ML0666 2026-05-30T13:09:52Z 898 ML1426 Q7AQ52 ML1426 Probable ABC-transport protein, inner membrane component 319 63.958 Moderate candidate 0.5965 ProteomeLM contextual shift 0.11677361 1.0 64 1.0 985 16 0.7153 0.7856 78.56 0.08 0.8625 ProteomeLM contextual percentile 0.60; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML1426 2026-05-30T13:09:52Z 899 ML1322 Q49780 prcB ML1322 Proteasome subunit beta (EC 3.4.25.1) (20S proteasome beta subunit) (Proteasome core protein PrcB) 291 63.955 Moderate candidate 0.1986 ProteomeLM contextual shift 0.06622538 1.0 42 1.0 895 4 0.5185 0.8303 83.03 0.685 1.0 3.4.25.1 PATHWAY: Protein degradation; proteasomal Pup-dependent pathway. {ECO:0000255|HAMAP-Rule:MF_02113}. proteasome ProteomeLM contextual percentile 0.20; strong pocket/AF2Bind evidence; essential-process annotation; high-confidence Boltz2 model; matched: proteasome /main_page_ml/ML1322 2026-05-30T13:09:52Z 900 ML2065 Q9CBE9 gnd ML2065 6-phosphogluconate dehydrogenase, decarboxylating (EC 1.1.1.44) 483 63.946 Moderate candidate 0.1679 ProteomeLM contextual shift 0.062684685 1.0 99 1.0 1465 32 0.9158 0.9369 93.69 0.685 1.0 1.1.1.44 PATHWAY: Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 3/3. {ECO:0000256|PIRNR:PIRNR000109, ECO:0000256|RuleBase:RU000485}. nad, dehydrogenase ProteomeLM contextual percentile 0.17; strong pocket/AF2Bind evidence; essential-process annotation; high-confidence Boltz2 model; matched: nad, dehydrogenase /main_page_ml/ML2065 2026-05-30T13:09:52Z 901 ML0564 Q9CCN9 ML0564 Putative gluconeogenesis factor 359 63.921 Moderate candidate 0.5357 ProteomeLM contextual shift 0.10735367 1.0 40 1.0 1122 90 0.9601 0.8571 85.71 0.08 1.0 transferase ProteomeLM contextual percentile 0.54; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: transferase /main_page_ml/ML0564 2026-05-30T13:09:52Z 902 ML0691 Q9CCM2 ML0691 D-alanyl-D-alanine carboxypeptidase 411 63.892 Moderate candidate 0.4417 ProteomeLM contextual shift 0.09675391 1.0 54 1.0 1274 2 0.6549 0.8107 81.07 0.335 0.8625 peptidoglycan, cell wall, d-alanine ProteomeLM contextual percentile 0.44; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: peptidoglycan, cell wall, d-alanine /main_page_ml/ML0691 2026-05-30T13:09:52Z 903 ML1840 O33002 rplO ML1840 MLCB2492.23 Large ribosomal subunit protein uL15 (50S ribosomal protein L15) 146 63.888 Moderate candidate 0.5526 ProteomeLM contextual shift 0.10956565 1.0 16 1.0 460 44 0.8519 0.6621 66.21 0.215 0.8625 translation, ribosome, ribosomal ProteomeLM contextual percentile 0.55; strong pocket/AF2Bind evidence; matched: translation, ribosome, ribosomal /main_page_ml/ML1840 2026-05-30T13:09:52Z 904 ML1724 Q9CBQ8 ML1724 Enoyl-CoA hydratase/isomerase 252 63.876 Moderate candidate 0.5138 ProteomeLM contextual shift 0.10429803 1.0 54 1.0 767 22 0.874 0.9294 92.94 0.08 1.0 isomerase, lyase ProteomeLM contextual percentile 0.51; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: isomerase, lyase /main_page_ml/ML1724 2026-05-30T13:09:52Z 905 ML1302 Q49784 mshC cysS2 ML1302 B2126_C2_193 L-cysteine:1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside ligase (L-Cys:GlcN-Ins ligase) (EC 6.3.1.13) (Mycothiol ligase) (MSH ligase) 412 63.873 Moderate candidate 0.2299 ProteomeLM contextual shift 0.069961704 1.0 56 1.0 1194 84 0.8485 0.9425 94.25 0.57 1.0 6.3.1.13 aminoacyl-trna, trna ligase, ligase, synthetase, cofactor ProteomeLM contextual percentile 0.23; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model; matched: aminoacyl-trna, trna ligase, ligase, synthetase, cofactor /main_page_ml/ML1302 2026-05-30T13:09:52Z 906 ML0427 O07708 orn ML0427 MLCL383.34c Oligoribonuclease (EC 3.1.15.-) 215 63.862 Moderate candidate 0.3647 ProteomeLM contextual shift 0.087969705 1.0 32 1.0 708 126 0.9869 0.8899 88.99 0.36 1.0 3.1.15.- ProteomeLM contextual percentile 0.36; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model /main_page_ml/ML0427 2026-05-30T13:09:52Z 907 ML2336 Q9CB73 ML2336 Aspartate transaminase 463 63.748 Moderate candidate 0.5182 ProteomeLM contextual shift 0.104598954 1.0 132 1.0 1411 4 0.5186 0.9012 90.12 0.08 1.0 transferase ProteomeLM contextual percentile 0.52; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: transferase /main_page_ml/ML2336 2026-05-30T13:09:52Z 908 ML1222 Q49626 ML1222 B1170_C3_229 Uncharacterized protein ML1222 198 63.725 Moderate candidate 0.5815 ProteomeLM contextual shift 0.11454214 1.0 16 1.0 601 14 0.6738 0.8149 81.49 0.08 0.8625 ProteomeLM contextual percentile 0.58; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML1222 2026-05-30T13:09:52Z 909 ML2393 P46808 greA ML2393 Transcription elongation factor GreA (Transcript cleavage factor GreA) 164 63.706 Moderate candidate 0.5426 ProteomeLM contextual shift 0.108186394 1.0 10 1.0 349 2 0.6039 0.769 76.9 0.17 0.8625 rna polymerase, transcription ProteomeLM contextual percentile 0.54; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: rna polymerase, transcription /main_page_ml/ML2393 2026-05-30T13:09:52Z 910 ML0370 Q9CCV6 ML0370 Alpha/beta hydrolase 289 63.701 Moderate candidate 0.5708 ProteomeLM contextual shift 0.1123517 1.0 54 1.0 883 32 0.7994 0.8723 87.23 0.0 1.0 hydrolase ProteomeLM contextual percentile 0.57; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: hydrolase /main_page_ml/ML0370 2026-05-30T13:09:52Z 911 ML2683 O53125 rpsR ML2683 MLCB1913.19c Small ribosomal subunit protein bS18 (30S ribosomal protein S18) 84 63.672 Moderate candidate 0.5294 ProteomeLM contextual shift 0.10665794 1.0 8 1.0 184 32 0.8962 0.8266 82.66 0.215 0.7575 translation, ribosome, ribosomal ProteomeLM contextual percentile 0.53; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: translation, ribosome, ribosomal /main_page_ml/ML2683 2026-05-30T13:09:52Z 912 ML0055 O33089 eccA1 ML0055 MLCB628.18c ESX-1 secretion system protein EccA1 (ESX conserved component A1) (Type VII secretion system protein EccA1) (T7SS protein EccA1) 573 63.652 Moderate candidate 0.5094 ProteomeLM contextual shift 0.10379034 1.0 117 1.0 1779 0 0.4184 0.8198 81.98 0.2 0.8625 ProteomeLM contextual percentile 0.51; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML0055 2026-05-30T13:09:52Z 913 ML2053 Q9CBF1 ML2053 Probable alcohol dehydrogenase AdhA (EC 1.1.1.1) 335 63.628 Moderate candidate 0.3145 ProteomeLM contextual shift 0.08077664 1.0 56 1.0 715 90 0.9631 0.9519 95.19 0.405 1.0 1.1.1.1 nad, dehydrogenase, cofactor ProteomeLM contextual percentile 0.31; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model; matched: nad, dehydrogenase, cofactor /main_page_ml/ML2053 2026-05-30T13:09:52Z 914 ML0019 Q50186 rodA ML0019 Peptidoglycan glycosyltransferase RodA (EC 2.4.99.28) (Non-canonical transglycosylase RodA) 465 63.615 Moderate candidate 0.1886 ProteomeLM contextual shift 0.0645912 1.0 104 1.0 1436 2 0.5131 0.8014 80.14 0.7 1.0 2.4.99.28 PATHWAY: Cell wall biogenesis; peptidoglycan biosynthesis. {ECO:0000250|UniProtKB:P9WN99}. cell division, peptidoglycan, cell wall, mur, transferase ProteomeLM contextual percentile 0.19; strong pocket/AF2Bind evidence; essential-process annotation; high-confidence Boltz2 model; matched: cell division, peptidoglycan, cell wall, mur, transferase /main_page_ml/ML0019 2026-05-30T13:09:52Z 915 ML1286 Q9CC47 ML1286 Transcriptional regulatory protein PdtaR 205 63.598 Moderate candidate 0.5695 ProteomeLM contextual shift 0.11198504 1.0 18 1.0 656 2 0.5187 0.7539 75.39 0.125 0.8625 transcription ProteomeLM contextual percentile 0.57; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: transcription /main_page_ml/ML1286 2026-05-30T13:09:52Z 916 ML2443 P54138 mshA ML2443 B2168_C2_201 u2168f D-inositol 3-phosphate glycosyltransferase (EC 2.4.1.250) (N-acetylglucosamine-inositol-phosphate N-acetylglucosaminyltransferase) (GlcNAc-Ins-P N-acetylglucosaminyltransferase) 428 63.586 Moderate candidate 0.2876 ProteomeLM contextual shift 0.07814428 1.0 132 1.0 881 50 0.9234 0.892 89.2 0.48 1.0 2.4.1.250 transferase ProteomeLM contextual percentile 0.29; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model; matched: transferase /main_page_ml/ML2443 2026-05-30T13:09:52Z 917 ML0811 Q9CCH3 rhlE ML0811 RNA helicase (EC 3.6.4.13) 544 63.569 Moderate candidate 0.4593 ProteomeLM contextual shift 0.09892683 1.0 108 1.0 1639 14 0.6721 0.6794 67.94 0.285 1.0 3.6.4.13 ribosome, hydrolase ProteomeLM contextual percentile 0.46; strong pocket/AF2Bind evidence; matched: ribosome, hydrolase /main_page_ml/ML0811 2026-05-30T13:09:52Z 918 ML2331 Q9CB75 ML2331 Possible secreted protein 256 63.564 Moderate candidate 0.5031 ProteomeLM contextual shift 0.10339473 1.0 22 1.0 534 44 0.937 0.893 89.3 0.17 0.8625 peptidoglycan, mur ProteomeLM contextual percentile 0.50; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: peptidoglycan, mur /main_page_ml/ML2331 2026-05-30T13:09:52Z 919 ML1260 Q9X7C0 hisH ML1260 MLCB1610.23 Imidazole glycerol phosphate synthase subunit HisH (EC 4.3.2.10) (IGP synthase glutaminase subunit) (EC 3.5.1.2) (IGP synthase subunit HisH) (ImGP synthase subunit HisH) (IGPS subunit HisH) 206 63.563 Moderate candidate 0.1754 ProteomeLM contextual shift 0.06335436 1.0 26 1.0 633 30 0.9 0.9622 96.22 0.64 1.0 3.5.1.2; 4.3.2.10 PATHWAY: Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 5/9. lyase, synthase ProteomeLM contextual percentile 0.18; strong pocket/AF2Bind evidence; essential-process annotation; high-confidence Boltz2 model; matched: lyase, synthase /main_page_ml/ML1260 2026-05-30T13:09:52Z 920 ML0275 Q9CCX4 metZ ML0275 O-succinylhomoserine sulfhydrylase (OSH sulfhydrylase) (OSHS sulfhydrylase) (EC 2.5.1.-) 406 63.454 Moderate candidate 0.2444 ProteomeLM contextual shift 0.071673684 1.0 197 1.0 1250 64 0.8445 0.9502 95.02 0.52 1.0 2.5.1.- PATHWAY: Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homocysteine from O-succinyl-L-homoserine: step 1/1. {ECO:0000256|HAMAP-Rule:MF_02056}. enzyme, transferase, lyase ProteomeLM contextual percentile 0.24; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model; matched: enzyme, transferase, lyase /main_page_ml/ML0275 2026-05-30T13:09:52Z 921 ML1408 Q9CC13 argB ML1408 Acetylglutamate kinase (EC 2.7.2.8) (N-acetyl-L-glutamate 5-phosphotransferase) (NAG kinase) (NAGK) 297 63.397 Moderate candidate 0.1842 ProteomeLM contextual shift 0.06419864 1.0 190 1.0 979 152 0.9823 0.915 91.5 0.64 1.0 2.7.2.8 PATHWAY: Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 2/4. {ECO:0000255|HAMAP-Rule:MF_00082}. kinase, transferase ProteomeLM contextual percentile 0.18; strong pocket/AF2Bind evidence; essential-process annotation; high-confidence Boltz2 model; matched: kinase, transferase /main_page_ml/ML1408 2026-05-30T13:09:52Z 922 ML0054 Q7AQN9 ML0054 Membrane protein 481 63.387 Moderate candidate 0.5288 ProteomeLM contextual shift 0.10664694 1.0 40 1.0 1484 2 0.5027 0.8278 82.78 0.08 1.0 hydrolase ProteomeLM contextual percentile 0.53; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: hydrolase /main_page_ml/ML0054 2026-05-30T13:09:52Z 923 ML2473 Q9CB33 ML2473 tRNA adenosine deaminase 159 63.377 Moderate candidate 0.5846 ProteomeLM contextual shift 0.11506702 1.0 18 1.0 481 8 0.6484 0.9292 92.92 0.0 0.8625 ProteomeLM contextual percentile 0.58; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML2473 2026-05-30T13:09:52Z 924 ML1401 Q9CC17 pheS ML1401 Phenylalanine--tRNA ligase alpha subunit (EC 6.1.1.20) (Phenylalanyl-tRNA synthetase alpha subunit) (PheRS) 341 63.324 Moderate candidate 0.2525 ProteomeLM contextual shift 0.07331405 1.0 59 1.0 1119 138 0.9945 0.8086 80.86 0.57 1.0 6.1.1.20 aminoacyl-trna, trna ligase, ligase, synthetase, cofactor ProteomeLM contextual percentile 0.25; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model; matched: aminoacyl-trna, trna ligase, ligase, synthetase, cofactor /main_page_ml/ML1401 2026-05-30T13:09:52Z 925 ML0468 Q49657 ML0468 Probable membrane transporter protein 260 63.322 Moderate candidate 0.5595 ProteomeLM contextual shift 0.11026028 1.0 44 1.0 827 94 0.9697 0.8514 85.14 0.08 0.8625 ProteomeLM contextual percentile 0.56; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML0468 2026-05-30T13:09:52Z 926 ML0031 O33075 ML0031 MLB1770.19c MLCB628.02c Proline-rich 28 kDa antigen homolog 278 63.292 Moderate candidate 0.6604 ProteomeLM contextual shift 0.12759429 1.0 29 1.0 854 40 0.8789 0.6553 65.53 0.0 0.8625 ProteomeLM contextual percentile 0.66; strong pocket/AF2Bind evidence /main_page_ml/ML0031 2026-05-30T13:09:52Z 927 ML1359 Q49897 nadK ML1359 MLC1351.13c NAD kinase (EC 2.7.1.23) (ATP-dependent NAD kinase) 311 63.272 Moderate candidate 0.2657 ProteomeLM contextual shift 0.075096965 1.0 114 1.0 956 46 0.9174 0.8474 84.74 0.525 1.0 2.7.1.23 nad, kinase, cofactor ProteomeLM contextual percentile 0.27; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model; matched: nad, kinase, cofactor /main_page_ml/ML1359 2026-05-30T13:09:52Z 928 ML1136 P45831 ML1136 Putative threonylcarbamoyl-AMP synthase (TC-AMP synthase) (EC 2.7.7.87) (L-threonylcarbamoyladenylate synthase) (tRNA threonylcarbamoyladenosine biosynthesis protein ML1136) 220 63.24 Moderate candidate 0.3076 ProteomeLM contextual shift 0.07985754 1.0 38 1.0 712 104 0.9873 0.9372 93.72 0.405 1.0 2.7.7.87 translation, synthase ProteomeLM contextual percentile 0.31; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model; matched: translation, synthase /main_page_ml/ML1136 2026-05-30T13:09:52Z 929 ML1553 Q9Z5I7 proS ML1553 MLCB596.17c Proline--tRNA ligase (EC 6.1.1.15) (Prolyl-tRNA synthetase) (ProRS) 480 63.23 Moderate candidate 0.2788 ProteomeLM contextual shift 0.07706411 1.0 74 1.0 1446 12 0.6213 0.9471 94.71 0.45 1.0 6.1.1.15 aminoacyl-trna, trna ligase, enzyme, ligase, synthetase ProteomeLM contextual percentile 0.28; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model; matched: aminoacyl-trna, trna ligase, enzyme, ligase, synthetase /main_page_ml/ML1553 2026-05-30T13:09:52Z 930 ML0240 Q9CD53 ML0240 Resuscitation-promoting factor RpfB 375 63.173 Moderate candidate 0.5301 ProteomeLM contextual shift 0.10667823 1.0 10 1.0 1185 0 0.3456 0.802 80.2 0.08 1.0 hydrolase ProteomeLM contextual percentile 0.53; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: hydrolase /main_page_ml/ML0240 2026-05-30T13:09:52Z 931 ML0169 Q7AQN2 ML0169 DUF1707 domain-containing protein 200 63.168 Moderate candidate 0.6078 ProteomeLM contextual shift 0.11822386 1.0 16 1.0 644 8 0.6722 0.8271 82.71 0.0 0.8625 ProteomeLM contextual percentile 0.61; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML0169 2026-05-30T13:09:52Z 932 ML0249 Q9CD44 glmU ML0249 Bifunctional protein GlmU [Includes: UDP-N-acetylglucosamine pyrophosphorylase (EC 2.7.7.23) (N-acetylglucosamine-1-phosphate uridyltransferase); Glucosamine-1-phosphate N-acetyltransferase (EC 2.3.1.157)] 492 63.162 Moderate candidate 0.1222 ProteomeLM contextual shift 0.053540826 1.0 214 1.0 1005 2 0.6243 0.9286 92.86 0.73 1.0 2.3.1.157; 2.7.7.23 PATHWAY: Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; N-acetyl-alpha-D-glucosamine 1-phosphate from alpha-D-glucosamine 6-phosphate (route II): step 2/2. {ECO:0000255|HAMAP-Rule:MF_01631}.; PATHWAY: Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; UDP-N-acetyl-alpha-D-glucosamine from N-acetyl-alpha-D-glucosamine 1-phosphate: step 1/1. {ECO:0000255|HAMAP-Rule:MF_01631}.; PATHWAY: Bacterial outer membrane biogenesis; LPS lipid A biosynthesis. {ECO:0000255|HAMAP-Rule:MF_01631}. peptidoglycan, cell wall, transferase, cofactor ProteomeLM contextual percentile 0.12; strong pocket/AF2Bind evidence; essential-process annotation; high-confidence Boltz2 model; matched: peptidoglycan, cell wall, transferase, cofactor /main_page_ml/ML0249 2026-05-30T13:09:52Z 933 ML1905 Q9CBK1 rplK ML1905 Large ribosomal subunit protein uL11 (50S ribosomal protein L11) 142 63.154 Moderate candidate 0.4856 ProteomeLM contextual shift 0.101447515 1.0 12 1.0 299 30 0.8474 0.8233 82.33 0.215 0.8625 translation, ribosome, ribosomal ProteomeLM contextual percentile 0.49; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: translation, ribosome, ribosomal /main_page_ml/ML1905 2026-05-30T13:09:52Z 934 ML2401 Q7APV2 ML2401 3-hydroxyisobutyryl-CoA hydrolase (EC 3.1.2.4) 345 63.142 Moderate candidate 0.3227 ProteomeLM contextual shift 0.0814263 1.0 60 1.0 1080 90 0.976 0.9648 96.48 0.36 1.0 3.1.2.4 hydrolase ProteomeLM contextual percentile 0.32; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model; matched: hydrolase /main_page_ml/ML2401 2026-05-30T13:09:52Z 935 ML1458 Q9CBZ7 proA ML1458 Gamma-glutamyl phosphate reductase (GPR) (EC 1.2.1.41) (Glutamate-5-semialdehyde dehydrogenase) (Glutamyl-gamma-semialdehyde dehydrogenase) (GSA dehydrogenase) 409 63.109 Moderate candidate 0.2124 ProteomeLM contextual shift 0.0675376 1.0 84 1.0 1247 40 0.7945 0.9374 93.74 0.565 1.0 1.2.1.41 PATHWAY: Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-glutamate: step 2/2. {ECO:0000255|HAMAP-Rule:MF_00412}. nad, dehydrogenase, reductase ProteomeLM contextual percentile 0.21; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model; matched: nad, dehydrogenase, reductase /main_page_ml/ML1458 2026-05-30T13:09:52Z 936 ML2561 Q7APU5 ML2561 Probable oxidoreductase 162 63.106 Moderate candidate 0.4774 ProteomeLM contextual shift 0.1007224 1.0 78 1.0 566 160 0.9949 0.8896 88.96 0.125 1.0 nad, oxidoreductase, reductase ProteomeLM contextual percentile 0.48; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: nad, oxidoreductase, reductase /main_page_ml/ML2561 2026-05-30T13:09:52Z 937 ML2301 Q9CB92 nth ML2301 Endonuclease III (EC 4.2.99.18) (DNA-(apurinic or apyrimidinic site) lyase) 245 63.104 Moderate candidate 0.2669 ProteomeLM contextual shift 0.07545621 1.0 40 1.0 773 28 0.7589 0.9162 91.62 0.48 1.0 4.2.99.18 lyase, cofactor ProteomeLM contextual percentile 0.27; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model; matched: lyase, cofactor /main_page_ml/ML2301 2026-05-30T13:09:52Z 938 ML1134 P45833 prfA ML1134 Peptide chain release factor 1 (RF-1) 361 63.1 Moderate candidate 0.5482 ProteomeLM contextual shift 0.10888229 1.0 52 1.0 762 0 0.4585 0.7786 77.86 0.125 0.8625 translation ProteomeLM contextual percentile 0.55; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: translation /main_page_ml/ML1134 2026-05-30T13:09:52Z 939 ML1368 Q7AQ60 ML1368 Segregation and condensation protein A 268 63.094 Moderate candidate 0.6378 ProteomeLM contextual shift 0.122488305 1.0 24 1.0 834 60 0.8191 0.5545 55.45 0.08 0.8625 ProteomeLM contextual percentile 0.64; strong pocket/AF2Bind evidence /main_page_ml/ML1368 2026-05-30T13:09:52Z 940 ML0150 Q9CD75 pgi ML0150 Glucose-6-phosphate isomerase (GPI) (EC 5.3.1.9) (Phosphoglucose isomerase) (PGI) (Phosphohexose isomerase) (PHI) 554 63.055 Moderate candidate 0.1623 ProteomeLM contextual shift 0.061803963 1.0 160 1.0 1665 6 0.6415 0.9575 95.75 0.64 1.0 5.3.1.9 PATHWAY: Carbohydrate biosynthesis; gluconeogenesis. {ECO:0000255|HAMAP-Rule:MF_00473}.; PATHWAY: Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 2/4. {ECO:0000255|HAMAP-Rule:MF_00473}. isomerase ProteomeLM contextual percentile 0.16; strong pocket/AF2Bind evidence; essential-process annotation; high-confidence Boltz2 model; matched: isomerase /main_page_ml/ML0150 2026-05-30T13:09:52Z 941 ML2387 Q50068 lpd ML2387 u1740l Dihydrolipoyl dehydrogenase (EC 1.8.1.4) (Dihydrolipoamide dehydrogenase) (E3 component of alpha-ketoacid dehydrogenase complexes) 467 63.042 Moderate candidate 0.2281 ProteomeLM contextual shift 0.06985891 1.0 114 1.0 1484 166 0.9783 0.9559 95.59 0.525 1.0 1.8.1.4 nad, oxidoreductase, dehydrogenase, reductase ProteomeLM contextual percentile 0.23; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model; matched: nad, oxidoreductase, dehydrogenase, reductase /main_page_ml/ML2387 2026-05-30T13:09:52Z 942 ML0591 Q7AQH7 ML0591 Membrane protein 593 63.036 Moderate candidate 0.5219 ProteomeLM contextual shift 0.10525008 1.0 118 1.0 1820 2 0.5662 0.8169 81.69 0.08 1.0 transferase ProteomeLM contextual percentile 0.52; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: transferase /main_page_ml/ML0591 2026-05-30T13:09:52Z 943 ML1276 Q9CC50 ML1276 Conserved membrane protein 146 63.018 Moderate candidate 0.6009 ProteomeLM contextual shift 0.11730827 1.0 32 1.0 489 102 0.9222 0.8362 83.62 0.0 0.8625 ProteomeLM contextual percentile 0.60; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML1276 2026-05-30T13:09:52Z 944 ML0543 Q9CCQ5 dfp coaBC ML0543 Coenzyme A biosynthesis bifunctional protein CoaBC (DNA/pantothenate metabolism flavoprotein) (Phosphopantothenoylcysteine synthetase/decarboxylase) (PPCS-PPCDC) [Includes: Phosphopantothenoylcysteine decarboxylase (PPC decarboxylase) (PPC-DC) (EC 4.1.1.36) (CoaC); Phosphopantothenate--cysteine ligase (EC 6.3.2.5) (CoaB) (Phosphopantothenoylcysteine synthetase) (PPC synthetase) (PPC-S)] 419 62.994 Moderate candidate 0.156 ProteomeLM contextual shift 0.06019803 1.0 264 1.0 1272 30 0.801 0.8834 88.34 0.685 1.0 4.1.1.36; 6.3.2.5 PATHWAY: Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 2/5. {ECO:0000256|HAMAP-Rule:MF_02225, ECO:0000256|RuleBase:RU364078}.; PATHWAY: Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 3/5. {ECO:0000256|HAMAP-Rule:MF_02225, ECO:0000256|RuleBase:RU364078}. cofactor biosynthesis, enzyme, ligase, synthetase ProteomeLM contextual percentile 0.16; strong pocket/AF2Bind evidence; essential-process annotation; high-confidence Boltz2 model; matched: cofactor biosynthesis, enzyme, ligase, synthetase /main_page_ml/ML0543 2026-05-30T13:09:52Z 945 ML1146 P45822 atpC ML1146 ATP synthase epsilon chain (ATP synthase F1 sector epsilon subunit) (F-ATPase epsilon subunit) 121 62.965 Moderate candidate 0.4568 ProteomeLM contextual shift 0.09825549 1.0 10 1.0 249 14 0.6537 0.9478 94.78 0.125 1.0 atp synthase, synthase ProteomeLM contextual percentile 0.46; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: atp synthase, synthase /main_page_ml/ML1146 2026-05-30T13:09:52Z 946 ML1577 Q9CBU6 ML1577 Probable penicillin binding protein 608 62.933 Moderate candidate 0.4893 ProteomeLM contextual shift 0.10181434 1.0 44 1.0 1884 0 0.2839 0.8781 87.81 0.17 0.8625 peptidoglycan, cell wall ProteomeLM contextual percentile 0.49; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: peptidoglycan, cell wall /main_page_ml/ML1577 2026-05-30T13:09:52Z 947 ML1029 Q7AQA7 ML1029 DUF3710 domain-containing protein 273 62.914 Moderate candidate 0.6385 ProteomeLM contextual shift 0.12256874 1.0 30 1.0 829 20 0.7557 0.6943 69.43 0.0 0.8625 ProteomeLM contextual percentile 0.64; strong pocket/AF2Bind evidence /main_page_ml/ML1029 2026-05-30T13:09:52Z 948 ML0062 Q9CDD4 gltD ML0062 NADH-dependent glutamate synthase small subunit (EC 1.4.1.13) 488 62.895 Moderate candidate 0.2719 ProteomeLM contextual shift 0.07576681 1.0 115 1.0 1034 116 0.965 0.9477 94.77 0.445 1.0 1.4.1.13 PATHWAY: Amino-acid biosynthesis. {ECO:0000256|ARBA:ARBA00029440}. nad, oxidoreductase, reductase, synthase ProteomeLM contextual percentile 0.27; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model; matched: nad, oxidoreductase, reductase, synthase /main_page_ml/ML0062 2026-05-30T13:09:52Z 949 ML2351 Q49935 ML2351 Probable antibiotic resistance membrane protein 288 62.814 Moderate candidate 0.5514 ProteomeLM contextual shift 0.10950451 1.0 65 1.0 874 20 0.8023 0.8291 82.91 0.08 0.8625 ProteomeLM contextual percentile 0.55; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML2351 2026-05-30T13:09:52Z 950 ML1831 Q7AQ22 mapA map ML1831 Methionine aminopeptidase (MAP) (MetAP) (EC 3.4.11.18) (Peptidase M) 266 62.782 Moderate candidate 0.245 ProteomeLM contextual shift 0.071711585 1.0 46 1.0 563 62 0.9931 0.9607 96.07 0.48 1.0 3.4.11.18 enzyme, protease, binding site ProteomeLM contextual percentile 0.24; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model; matched: enzyme, protease, binding site /main_page_ml/ML1831 2026-05-30T13:09:52Z 951 ML1406 Q9CC15 argC ML1406 N-acetyl-gamma-glutamyl-phosphate reductase (AGPR) (EC 1.2.1.38) (N-acetyl-glutamate semialdehyde dehydrogenase) (NAGSA dehydrogenase) 347 62.78 Moderate candidate 0.131 ProteomeLM contextual shift 0.055409208 1.0 100 1.0 1098 114 0.966 0.9497 94.97 0.685 1.0 1.2.1.38 PATHWAY: Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 3/4. {ECO:0000255|HAMAP-Rule:MF_00150}. nad, dehydrogenase, reductase ProteomeLM contextual percentile 0.13; strong pocket/AF2Bind evidence; essential-process annotation; high-confidence Boltz2 model; matched: nad, dehydrogenase, reductase /main_page_ml/ML1406 2026-05-30T13:09:52Z 952 ML2617 O06079 mmpL11 ML2617 MLCL622.16c Probable transport protein MmpL11 1014 62.768 Moderate candidate 0.5583 ProteomeLM contextual shift 0.11016922 1.0 197 1.0 3099 0 0.3668 0.7854 78.54 0.125 0.7875 cell division ProteomeLM contextual percentile 0.56; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: cell division /main_page_ml/ML2617 2026-05-30T13:09:52Z 953 ML0379 P37969 tsaD gcp ML0379 B1620_C3_226 B229_C3_246 u1620c u229e tRNA N6-adenosine threonylcarbamoyltransferase (EC 2.3.1.234) (N6-L-threonylcarbamoyladenine synthase) (t(6)A synthase) (t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaD) (tRNA threonylcarbamoyladenosine biosynthesis protein TsaD) 351 62.71 Moderate candidate 0.2531 ProteomeLM contextual shift 0.07346699 1.0 68 1.0 1081 56 0.9073 0.925 92.5 0.48 1.0 2.3.1.234 transferase, synthase, cofactor ProteomeLM contextual percentile 0.25; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model; matched: transferase, synthase, cofactor /main_page_ml/ML0379 2026-05-30T13:09:52Z 954 ML1768 Q9CBN8 uspA ML1768 Sugar transport integral membrane protein 328 62.69 Moderate candidate 0.5758 ProteomeLM contextual shift 0.11318753 1.0 74 1.0 993 18 0.765 0.7311 73.11 0.08 0.8625 ProteomeLM contextual percentile 0.58; strong pocket/AF2Bind evidence /main_page_ml/ML1768 2026-05-30T13:09:52Z 955 ML2472 Q9CB34 ML2472 Possible prephenate dehydrogenase 327 62.684 Moderate candidate 0.4555 ProteomeLM contextual shift 0.098204784 1.0 50 1.0 1051 140 0.9814 0.9241 92.41 0.125 1.0 nad, dehydrogenase ProteomeLM contextual percentile 0.46; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: nad, dehydrogenase /main_page_ml/ML2472 2026-05-30T13:09:52Z 956 ML0532 Q9CCR5 pyrB ML0532 Aspartate carbamoyltransferase catalytic subunit (EC 2.1.3.2) (Aspartate transcarbamylase) (ATCase) 321 62.683 Moderate candidate 0.1717 ProteomeLM contextual shift 0.06318951 1.0 54 1.0 967 8 0.8067 0.8874 88.74 0.64 1.0 2.1.3.2 PATHWAY: Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 2/3. {ECO:0000255|HAMAP-Rule:MF_00001}. transferase ProteomeLM contextual percentile 0.17; strong pocket/AF2Bind evidence; essential-process annotation; high-confidence Boltz2 model; matched: transferase /main_page_ml/ML0532 2026-05-30T13:09:52Z 957 ML0387 Q49729 guaB ML0387 B1620_C3_238 Inosine-5'-monophosphate dehydrogenase (IMP dehydrogenase) (IMPD) (IMPDH) (EC 1.1.1.205) 529 62.655 Moderate candidate 0.1566 ProteomeLM contextual shift 0.061096534 1.0 355 1.0 1600 26 0.6451 0.8472 84.72 0.685 1.0 1.1.1.205 PATHWAY: Purine metabolism; XMP biosynthesis via de novo pathway; XMP from IMP: step 1/1. {ECO:0000255|HAMAP-Rule:MF_01964}. nad, dehydrogenase, cofactor ProteomeLM contextual percentile 0.16; strong pocket/AF2Bind evidence; essential-process annotation; high-confidence Boltz2 model; matched: nad, dehydrogenase, cofactor /main_page_ml/ML0387 2026-05-30T13:09:52Z 958 ML0848 Q9CCF9 ML0848 ABC transporter 724 62.649 Moderate candidate 0.5852 ProteomeLM contextual shift 0.11512791 1.0 144 1.0 2258 172 0.9541 0.6942 69.42 0.08 0.8625 ProteomeLM contextual percentile 0.59; strong pocket/AF2Bind evidence /main_page_ml/ML0848 2026-05-30T13:09:52Z 959 ML0571 P46712 pgk ML0571 B1496_C2_162 Phosphoglycerate kinase (EC 2.7.2.3) 416 62.645 Moderate candidate 0.1629 ProteomeLM contextual shift 0.062184453 1.0 106 1.0 1263 30 0.8803 0.9143 91.43 0.64 1.0 2.7.2.3 PATHWAY: Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 2/5. kinase ProteomeLM contextual percentile 0.16; strong pocket/AF2Bind evidence; essential-process annotation; high-confidence Boltz2 model; matched: kinase /main_page_ml/ML0571 2026-05-30T13:09:52Z 960 ML0093 Q9CDB7 ML0093 Galactofuranosyltransferase GlfT2 (EC 2.4.1.288) (Arabinogalactan galactosyltransferase 2) (Galactofuranosylgalactofuranosylrhamnosyl-N-acetylglucosaminyl-diphospho-decaprenol beta-1,5/1,6-galactofuranosyltransferase) (Polymerizing galactofuranosyltransferase GlfT2) 643 62.63 Moderate candidate 0.198 ProteomeLM contextual shift 0.066155285 1.0 387 1.0 1947 36 0.8522 0.94 94.0 0.565 1.0 2.4.1.288 PATHWAY: Cell wall biogenesis; cell wall polysaccharide biosynthesis. {ECO:0000256|ARBA:ARBA00004776}. cell wall, transferase, cofactor ProteomeLM contextual percentile 0.20; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model; matched: cell wall, transferase, cofactor /main_page_ml/ML0093 2026-05-30T13:09:52Z 961 ML1114 Q9CC88 ML1114 Probable ABC transporter protein, ATP-binding component 584 62.61 Moderate candidate 0.5633 ProteomeLM contextual shift 0.11092312 1.0 93 1.0 1178 20 0.7977 0.767 76.7 0.08 0.8625 ProteomeLM contextual percentile 0.56; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML1114 2026-05-30T13:09:52Z 962 ML0089 Q9CDB9 ML0089 Hydrolase 281 62.589 Moderate candidate 0.4799 ProteomeLM contextual shift 0.100875564 1.0 24 1.0 589 54 0.9292 0.919 91.9 0.08 1.0 hydrolase ProteomeLM contextual percentile 0.48; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: hydrolase /main_page_ml/ML0089 2026-05-30T13:09:52Z 963 ML2055 P46842 apa modD ML2055 MLCB1788.01c Alanine and proline-rich secreted protein Apa (Antigen 43L) (FAP-L) (Fibronectin attachment protein) 287 62.576 Moderate candidate 0.6015 ProteomeLM contextual shift 0.11736631 1.0 132 1.0 874 26 0.7662 0.6299 62.99 0.08 0.8625 ProteomeLM contextual percentile 0.60; strong pocket/AF2Bind evidence /main_page_ml/ML2055 2026-05-30T13:09:52Z 964 ML0901 Q7AQD0 ML0901 Methylenetetrahydrofolate reductase 304 62.571 Moderate candidate 0.5 ProteomeLM contextual shift 0.10271752 1.0 48 1.0 995 166 0.9938 0.9171 91.71 0.045 1.0 folate, reductase ProteomeLM contextual percentile 0.50; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: folate, reductase /main_page_ml/ML0901 2026-05-30T13:09:52Z 965 ML0634 P38119 uppS ML0634 B1937_F2_65 Decaprenyl diphosphate synthase (DecaPP) (EC 2.5.1.86) (EC 2.5.1.87) (Decaprenyl pyrophosphate synthase) (Long-chain isoprenyl diphosphate synthase) (Trans,polycis-decaprenyl diphosphate synthase) 296 62.556 Moderate candidate 0.2481 ProteomeLM contextual shift 0.07221923 1.0 72 1.0 935 94 0.9851 0.9272 92.72 0.48 1.0 2.5.1.86; 2.5.1.87 synthase, cofactor ProteomeLM contextual percentile 0.25; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model; matched: synthase, cofactor /main_page_ml/ML0634 2026-05-30T13:09:52Z 966 ML0458 Q9CCT9 ML0458 Oxidoreductase 301 62.508 Moderate candidate 0.4793 ProteomeLM contextual shift 0.100852616 1.0 24 1.0 638 72 0.966 0.9132 91.32 0.08 1.0 oxidoreductase, reductase ProteomeLM contextual percentile 0.48; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: oxidoreductase, reductase /main_page_ml/ML0458 2026-05-30T13:09:52Z 967 ML0156 Q7AQN6 sucD ML0156 Succinate--CoA ligase [ADP-forming] subunit alpha (EC 6.2.1.5) (Succinyl-CoA synthetase subunit alpha) (SCS-alpha) 300 62.488 Moderate candidate 0.1541 ProteomeLM contextual shift 0.059961747 1.0 98 1.0 954 108 0.9638 0.9293 92.93 0.64 1.0 6.2.1.5 PATHWAY: Carbohydrate metabolism; tricarboxylic acid cycle; succinate from succinyl-CoA (ligase route): step 1/1. {ECO:0000256|HAMAP-Rule:MF_01988, ECO:0000256|RuleBase:RU000699}. ligase, synthetase ProteomeLM contextual percentile 0.15; strong pocket/AF2Bind evidence; essential-process annotation; high-confidence Boltz2 model; matched: ligase, synthetase /main_page_ml/ML0156 2026-05-30T13:09:52Z 968 ML1548 Q7AQ44 ML1548 Calcineurin-like phosphoesterase domain-containing protein 321 62.476 Moderate candidate 0.4718 ProteomeLM contextual shift 0.10005561 1.0 56 1.0 693 102 0.9244 0.9363 93.63 0.08 1.0 hydrolase ProteomeLM contextual percentile 0.47; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: hydrolase /main_page_ml/ML1548 2026-05-30T13:09:52Z 969 ML0990 Q7AQB8 ML0990 Possible conserved membrane protein 209 62.461 Moderate candidate 0.619 ProteomeLM contextual shift 0.11975988 1.0 16 1.0 653 12 0.6735 0.7169 71.69 0.0 0.8625 ProteomeLM contextual percentile 0.62; strong pocket/AF2Bind evidence /main_page_ml/ML0990 2026-05-30T13:09:52Z 970 ML0020 Q9CDE5 ML0020 Serine/threonine protein phosphatase PstP (EC 3.1.3.16) (Mycobacterial Ser/Thr phosphatase) (PP2C-family Ser/Thr phosphatase) 509 62.461 Moderate candidate 0.3941 ProteomeLM contextual shift 0.09199962 1.0 44 1.0 1536 18 0.6397 0.6467 64.67 0.36 1.0 3.1.3.16 cofactor ProteomeLM contextual percentile 0.39; strong pocket/AF2Bind evidence; functional annotation support; matched: cofactor /main_page_ml/ML0020 2026-05-30T13:09:52Z 971 ML1616 O33016 rimM ML1616 MLCB250.34 Ribosome maturation factor RimM 179 62.441 Moderate candidate 0.4981 ProteomeLM contextual shift 0.1026444 1.0 18 1.0 559 44 0.7876 0.7982 79.82 0.17 0.8625 ribosome, ribosomal ProteomeLM contextual percentile 0.50; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: ribosome, ribosomal /main_page_ml/ML1616 2026-05-30T13:09:52Z 972 ML1306 Q9CC38 ML1306 Carboxylate--amine ligase 274 62.397 Moderate candidate 0.5407 ProteomeLM contextual shift 0.107833885 1.0 141 1.0 876 108 0.9462 0.8472 84.72 0.0 1.0 ligase ProteomeLM contextual percentile 0.54; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: ligase /main_page_ml/ML1306 2026-05-30T13:09:52Z 973 ML0773 Q9CCJ2 mtrA ML0773 DNA-binding response regulator MtrA 225 62.377 Moderate candidate 0.5338 ProteomeLM contextual shift 0.10727246 1.0 18 1.0 686 10 0.7258 0.7568 75.68 0.125 0.8625 transcription ProteomeLM contextual percentile 0.53; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: transcription /main_page_ml/ML0773 2026-05-30T13:09:52Z 974 ML0199 Q7AQM4 ML0199 ML0199 protein 200 62.323 Moderate candidate 0.5664 ProteomeLM contextual shift 0.111486726 1.0 34 1.0 618 36 0.8272 0.8873 88.73 0.0 0.8625 ProteomeLM contextual percentile 0.57; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML0199 2026-05-30T13:09:52Z 975 ML1150 P45821 murA murZ ML1150 UDP-N-acetylglucosamine 1-carboxyvinyltransferase (EC 2.5.1.7) (Enoylpyruvate transferase) (UDP-N-acetylglucosamine enolpyruvyl transferase) (EPT) 418 62.294 Moderate candidate 0.042 ProteomeLM contextual shift 0.030770065 1.0 71 1.0 1327 146 0.9742 0.9424 94.24 0.82 1.0 2.5.1.7 PATHWAY: Cell wall biogenesis; peptidoglycan biosynthesis. {ECO:0000255|HAMAP-Rule:MF_00111}. cell division, peptidoglycan, cell wall, mur, transferase, synthase ProteomeLM contextual percentile 0.04; strong pocket/AF2Bind evidence; essential-process annotation; high-confidence Boltz2 model; matched: cell division, peptidoglycan, cell wall, mur, transferase /main_page_ml/ML1150 2026-05-30T13:09:52Z 976 ML1310 Q49776 hisG ML1310 B2126_C1_162 MLCB2533.07 ATP phosphoribosyltransferase (ATP-PRT) (ATP-PRTase) (EC 2.4.2.17) 287 62.272 Moderate candidate 0.2231 ProteomeLM contextual shift 0.06929332 1.0 230 1.0 897 60 0.8652 0.9065 90.65 0.52 1.0 2.4.2.17 PATHWAY: Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/9. transferase, cofactor ProteomeLM contextual percentile 0.22; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model; matched: transferase, cofactor /main_page_ml/ML1310 2026-05-30T13:09:52Z 977 ML0107 Q9CDA6 aftA ML0107 Galactan 5-O-arabinofuranosyltransferase (EC 2.4.2.46) (Arabinofuranosyltransferase AftA) 632 62.232 Moderate candidate 0.1892 ProteomeLM contextual shift 0.06466923 1.0 211 1.0 1900 8 0.842 0.931 93.1 0.565 1.0 2.4.2.46 PATHWAY: Cell wall biogenesis; cell wall polysaccharide biosynthesis. {ECO:0000250|UniProtKB:P9WN03}. cell wall, transferase ProteomeLM contextual percentile 0.19; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model; matched: cell wall, transferase /main_page_ml/ML0107 2026-05-30T13:09:52Z 978 ML0891 Q7AQD8 ML0891 Uncharacterized protein 130 62.208 Moderate candidate 0.6811 ProteomeLM contextual shift 0.13078722 1.0 14 1.0 424 68 0.9092 0.4746 47.46 0.0 0.8625 ProteomeLM contextual percentile 0.68; strong pocket/AF2Bind evidence /main_page_ml/ML0891 2026-05-30T13:09:52Z 979 ML0451 Q7AQJ1 ML0451 Nudix hydrolase domain-containing protein 349 62.15 Moderate candidate 0.5125 ProteomeLM contextual shift 0.10421338 1.0 38 1.0 751 106 0.9755 0.7612 76.12 0.08 1.0 hydrolase, cofactor ProteomeLM contextual percentile 0.51; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: hydrolase, cofactor /main_page_ml/ML0451 2026-05-30T13:09:52Z 980 ML2042 Q9CBF5 ahpC ML2042 Alkyl hydroperoxide reductase C (EC 1.11.1.28) (Peroxiredoxin) (Thioredoxin peroxidase) 195 62.138 Moderate candidate 0.2381 ProteomeLM contextual shift 0.070919245 1.0 206 1.0 591 12 0.6399 0.9205 92.05 0.48 1.0 1.11.1.28 reductase ProteomeLM contextual percentile 0.24; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model; matched: reductase /main_page_ml/ML2042 2026-05-30T13:09:52Z 981 ML1597 O33039 tsf ML1597 MLCB250.64 Elongation factor Ts (EF-Ts) 276 62.132 Moderate candidate 0.4987 ProteomeLM contextual shift 0.10264574 1.0 60 1.0 835 14 0.72 0.855 85.5 0.125 0.8625 translation ProteomeLM contextual percentile 0.50; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: translation /main_page_ml/ML1597 2026-05-30T13:09:52Z 982 ML1293 P46727 pyrD ML1293 B2126_F3_143 Dihydroorotate dehydrogenase (quinone) (EC 1.3.5.2) (DHOdehase) (DHOD) (DHODase) (Dihydroorotate oxidase) 356 62.113 Moderate candidate 0.1435 ProteomeLM contextual shift 0.058207978 1.0 68 1.0 1150 158 0.9874 0.9291 92.91 0.64 1.0 1.3.5.2 PATHWAY: Pyrimidine metabolism; UMP biosynthesis via de novo pathway; orotate from (S)-dihydroorotate (quinone route): step 1/1. dehydrogenase, cofactor ProteomeLM contextual percentile 0.14; strong pocket/AF2Bind evidence; essential-process annotation; high-confidence Boltz2 model; matched: dehydrogenase, cofactor /main_page_ml/ML1293 2026-05-30T13:09:52Z 983 ML0675 Q7AQG3 ML0675 Integral membrane protein 91 62.098 Moderate candidate 0.614 ProteomeLM contextual shift 0.11887236 1.0 14 1.0 313 80 0.9493 0.8032 80.32 0.0 0.7575 ProteomeLM contextual percentile 0.61; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML0675 2026-05-30T13:09:52Z 984 ML0113 Q9CDA1 rfbE ML0113 Glycosyl transferase 283 62.098 Moderate candidate 0.3496 ProteomeLM contextual shift 0.085939586 1.0 58 1.0 988 278 0.995 0.9162 91.62 0.285 1.0 PATHWAY: Cell wall biogenesis; cell wall polysaccharide biosynthesis. {ECO:0000256|ARBA:ARBA00004776}. cell wall, transferase ProteomeLM contextual percentile 0.35; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: cell wall, transferase /main_page_ml/ML0113 2026-05-30T13:09:52Z 985 ML2296 Q9CB97 ML2296 Membrane protein 181 62.071 Moderate candidate 0.6623 ProteomeLM contextual shift 0.12771119 1.0 10 1.0 603 0 0.4538 0.5266 52.66 0.0 0.8625 ProteomeLM contextual percentile 0.66; strong pocket/AF2Bind evidence /main_page_ml/ML2296 2026-05-30T13:09:52Z 986 ML0005 Q59533 gyrB ML0005 DNA gyrase subunit B (EC 5.6.2.2) 678 62.045 Moderate candidate 0.1479 ProteomeLM contextual shift 0.059055287 1.0 91 1.0 2045 22 0.7431 0.7769 77.69 0.705 1.0 5.6.2.2 dna replication, replication, dna gyrase, gyrase, isomerase, cofactor ProteomeLM contextual percentile 0.15; strong pocket/AF2Bind evidence; essential-process annotation; high-confidence Boltz2 model; matched: dna replication, replication, dna gyrase, gyrase, isomerase /main_page_ml/ML0005 2026-05-30T13:09:52Z 987 ML0238 Q9CD55 metG metS ML0238 Methionine--tRNA ligase (EC 6.1.1.10) (Methionyl-tRNA synthetase) (MetRS) 537 62.043 Moderate candidate 0.183 ProteomeLM contextual shift 0.06411941 1.0 42 1.0 1648 74 0.8934 0.924 92.4 0.57 1.0 6.1.1.10 aminoacyl-trna, trna ligase, ligase, synthetase ProteomeLM contextual percentile 0.18; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model; matched: aminoacyl-trna, trna ligase, ligase, synthetase /main_page_ml/ML0238 2026-05-30T13:09:52Z 988 ML2703 P46843 trxB/A trx ML2703 Bifunctional thioredoxin reductase/thioredoxin [Includes: Thioredoxin reductase (TRXR) (EC 1.8.1.9); Thioredoxin] 458 62.034 Moderate candidate 0.24 ProteomeLM contextual shift 0.07101481 1.0 115 1.0 1419 90 0.9656 0.8135 81.35 0.525 1.0 1.8.1.9 nad, oxidoreductase, reductase, cofactor ProteomeLM contextual percentile 0.24; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model; matched: nad, oxidoreductase, reductase, cofactor /main_page_ml/ML2703 2026-05-30T13:09:52Z 989 ML2672 Q7APS3 icd2 ML2672 Isocitrate dehydrogenase [NADP] (EC 1.1.1.42) (Oxalosuccinate decarboxylase) 746 62.013 Moderate candidate 0.2112 ProteomeLM contextual shift 0.067485444 1.0 124 1.0 2298 0 0.3228 0.9123 91.23 0.525 1.0 1.1.1.42 nad, dehydrogenase, cofactor ProteomeLM contextual percentile 0.21; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model; matched: nad, dehydrogenase, cofactor /main_page_ml/ML2672 2026-05-30T13:09:52Z 990 ML0555 Q9CCP8 ribG ML0555 Riboflavin biosynthesis protein RibD [Includes: Diaminohydroxyphosphoribosylaminopyrimidine deaminase (DRAP deaminase) (EC 3.5.4.26) (Riboflavin-specific deaminase); 5-amino-6-(5-phosphoribosylamino)uracil reductase (EC 1.1.1.193) (HTP reductase)] 339 62.013 Moderate candidate 0.0877 ProteomeLM contextual shift 0.045336362 1.0 142 1.0 683 10 0.5971 0.9343 93.43 0.73 1.0 1.1.1.193; 3.5.4.26 PATHWAY: Cofactor biosynthesis; riboflavin biosynthesis; 5-amino-6-(D-ribitylamino)uracil from GTP: step 2/4. {ECO:0000256|ARBA:ARBA00004882, ECO:0000256|PIRNR:PIRNR006769}.; PATHWAY: Cofactor biosynthesis; riboflavin biosynthesis; 5-amino-6-(D-ribitylamino)uracil from GTP: step 3/4. {ECO:0000256|ARBA:ARBA00004910, ECO:0000256|PIRNR:PIRNR006769}. nad, cofactor biosynthesis, reductase, cofactor ProteomeLM contextual percentile 0.09; strong pocket/AF2Bind evidence; essential-process annotation; high-confidence Boltz2 model; matched: nad, cofactor biosynthesis, reductase, cofactor /main_page_ml/ML0555 2026-05-30T13:09:52Z 991 ML0798 Q9CCI1 ML0798 Uncharacterized protein 592 62.002 Moderate candidate 0.5313 ProteomeLM contextual shift 0.10671389 1.0 90 1.0 1798 4 0.5638 0.728 72.8 0.125 0.8625 cell division ProteomeLM contextual percentile 0.53; strong pocket/AF2Bind evidence; matched: cell division /main_page_ml/ML0798 2026-05-30T13:09:52Z 992 ML2419 P46723 hemB ML2419 B2168_C3_264 Delta-aminolevulinic acid dehydratase (ALAD) (ALADH) (EC 4.2.1.24) (Porphobilinogen synthase) 329 61.993 Moderate candidate 0.1391 ProteomeLM contextual shift 0.05732173 1.0 227 1.0 1067 160 0.9707 0.9324 93.24 0.64 1.0 4.2.1.24 PATHWAY: Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 1/4. synthase ProteomeLM contextual percentile 0.14; strong pocket/AF2Bind evidence; essential-process annotation; high-confidence Boltz2 model; matched: synthase /main_page_ml/ML2419 2026-05-30T13:09:52Z 993 ML1960 Q9X7A1 rpsM ML1960 MLCB1222.30c Small ribosomal subunit protein uS13 (30S ribosomal protein S13) 124 61.979 Moderate candidate 0.4749 ProteomeLM contextual shift 0.10044262 1.0 14 1.0 293 90 0.9644 0.7431 74.31 0.215 0.8625 translation, ribosome, ribosomal ProteomeLM contextual percentile 0.47; strong pocket/AF2Bind evidence; matched: translation, ribosome, ribosomal /main_page_ml/ML1960 2026-05-30T13:09:52Z 994 ML0518 Q9CCS4 aroB ML0518 3-dehydroquinate synthase (DHQS) (EC 4.2.3.4) 361 61.967 Moderate candidate 0.1103 ProteomeLM contextual shift 0.050087687 1.0 30 1.0 744 44 0.8339 0.9407 94.07 0.685 1.0 4.2.3.4 PATHWAY: Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 2/7. {ECO:0000255|HAMAP-Rule:MF_00110}. nad, synthase, cofactor ProteomeLM contextual percentile 0.11; strong pocket/AF2Bind evidence; essential-process annotation; high-confidence Boltz2 model; matched: nad, synthase, cofactor /main_page_ml/ML0518 2026-05-30T13:09:52Z 995 ML0096 Q9CDB4 ML0096 Membrane protein 649 61.914 Moderate candidate 0.5539 ProteomeLM contextual shift 0.10979711 1.0 125 1.0 1950 6 0.6587 0.8903 89.03 0.0 0.8625 ProteomeLM contextual percentile 0.55; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML0096 2026-05-30T13:09:52Z 996 ML1448 Q9CC01 ML1448 RNA polymerase sigma factor 184 61.907 Moderate candidate 0.4868 ProteomeLM contextual shift 0.10150815 1.0 42 1.0 375 14 0.7825 0.7842 78.42 0.17 0.8625 rna polymerase, transcription ProteomeLM contextual percentile 0.49; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: rna polymerase, transcription /main_page_ml/ML1448 2026-05-30T13:09:52Z 997 ML2551 Q9CD24 aac ML2551 Aminoglycoside 2'-N-acetyltransferase 182 61.867 Moderate candidate 0.4586 ProteomeLM contextual shift 0.098879024 1.0 50 1.0 603 114 0.987 0.9215 92.15 0.08 1.0 transferase ProteomeLM contextual percentile 0.46; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: transferase /main_page_ml/ML2551 2026-05-30T13:09:52Z 998 ML0248 Q9CD45 prs prsA ML0248 Ribose-phosphate pyrophosphokinase (RPPK) (EC 2.7.6.1) (5-phospho-D-ribosyl alpha-1-diphosphate synthase) (Phosphoribosyl diphosphate synthase) (Phosphoribosyl pyrophosphate synthase) (P-Rib-PP synthase) (PRPP synthase) (PRPPase) 327 61.821 Moderate candidate 0.1441 ProteomeLM contextual shift 0.058260165 1.0 263 1.0 1015 68 0.9194 0.8977 89.77 0.64 1.0 2.7.6.1 PATHWAY: Metabolic intermediate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route I): step 1/1. {ECO:0000255|HAMAP-Rule:MF_00583}. kinase, synthase, cofactor ProteomeLM contextual percentile 0.14; strong pocket/AF2Bind evidence; essential-process annotation; high-confidence Boltz2 model; matched: kinase, synthase, cofactor /main_page_ml/ML0248 2026-05-30T13:09:52Z 999 ML0552 Q9CCQ0 fmt ML0552 Methionyl-tRNA formyltransferase (EC 2.1.2.9) 318 61.804 Moderate candidate 0.2005 ProteomeLM contextual shift 0.066349745 1.0 26 1.0 1015 122 0.9497 0.9286 92.86 0.525 1.0 2.1.2.9 folate, transferase ProteomeLM contextual percentile 0.20; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model; matched: folate, transferase /main_page_ml/ML0552 2026-05-30T13:09:52Z 1000 ML0323 P57990 cysS cysS1 ML0323 Cysteine--tRNA ligase (EC 6.1.1.16) (Cysteinyl-tRNA synthetase) (CysRS) 473 61.799 Moderate candidate 0.1873 ProteomeLM contextual shift 0.064543866 1.0 82 1.0 1430 22 0.7141 0.8842 88.42 0.57 1.0 6.1.1.16 aminoacyl-trna, trna ligase, ligase, synthetase, cofactor ProteomeLM contextual percentile 0.19; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model; matched: aminoacyl-trna, trna ligase, ligase, synthetase, cofactor /main_page_ml/ML0323 2026-05-30T13:09:52Z 1001 ML2346 Q49942 ML2346 Methyltransferase FkbM domain-containing protein 301 61.78 Moderate candidate 0.5069 ProteomeLM contextual shift 0.103579804 1.0 32 1.0 1046 286 0.9988 0.9039 90.39 0.0 1.0 transferase ProteomeLM contextual percentile 0.51; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: transferase /main_page_ml/ML2346 2026-05-30T13:09:52Z 1002 ML1099 Q9CC94 lprE ML1099 Putative lipoprotein LprE 202 61.775 Moderate candidate 0.5752 ProteomeLM contextual shift 0.11302135 1.0 26 1.0 437 26 0.866 0.6419 64.19 0.08 0.8625 ProteomeLM contextual percentile 0.58; strong pocket/AF2Bind evidence /main_page_ml/ML1099 2026-05-30T13:09:52Z 1003 ML1671 O69460 recG ML1671 MLCB1243.01 ATP-dependent DNA helicase RecG (EC 5.6.2.4) (DNA branch migration protein RecG) (Probable DNA 3'-5' helicase RecG) 743 61.774 Moderate candidate 0.2644 ProteomeLM contextual shift 0.0748616 1.0 130 1.0 2255 12 0.6491 0.7919 79.19 0.48 1.0 5.6.2.4 ProteomeLM contextual percentile 0.26; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model /main_page_ml/ML1671 2026-05-30T13:09:52Z 1004 ML1463 Q9CBZ6 nadE ML1463 Glutamine-dependent NAD(+) synthetase (EC 6.3.5.1) (NAD(+) synthase [glutamine-hydrolyzing]) 680 61.758 Moderate candidate 0.0783 ProteomeLM contextual shift 0.04235527 1.0 104 1.0 1400 0 0.4309 0.9417 94.17 0.73 1.0 6.3.5.1 PATHWAY: Cofactor biosynthesis; NAD(+) biosynthesis; NAD(+) from deamido-NAD(+) (L-Gln route): step 1/1. {ECO:0000255|HAMAP-Rule:MF_02090}. nad, cofactor biosynthesis, synthetase, synthase, cofactor ProteomeLM contextual percentile 0.08; strong pocket/AF2Bind evidence; essential-process annotation; high-confidence Boltz2 model; matched: nad, cofactor biosynthesis, synthetase, synthase, cofactor /main_page_ml/ML1463 2026-05-30T13:09:52Z 1005 ML0234 P24094 lsr2 ML0234 Nucleoid-associated protein Lsr2 (15 kDa antigen) (A15) 112 61.757 Moderate candidate 0.5533 ProteomeLM contextual shift 0.10972406 1.0 10 1.0 419 166 0.9926 0.6843 68.43 0.08 0.895 transferase ProteomeLM contextual percentile 0.55; strong pocket/AF2Bind evidence; matched: transferase /main_page_ml/ML0234 2026-05-30T13:09:52Z 1006 ML0456 O07151 thrS ML0456 MLCL581.18c Threonine--tRNA ligase (EC 6.1.1.3) (Threonyl-tRNA synthetase) (ThrRS) 702 61.723 Moderate candidate 0.1949 ProteomeLM contextual shift 0.06554646 1.0 164 1.0 2109 6 0.5635 0.8503 85.03 0.57 1.0 6.1.1.3 aminoacyl-trna, trna ligase, ligase, synthetase, cofactor ProteomeLM contextual percentile 0.19; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model; matched: aminoacyl-trna, trna ligase, ligase, synthetase, cofactor /main_page_ml/ML0456 2026-05-30T13:09:52Z 1007 ML0101 Q9CDB1 pks13 ML0101 Polyketide synthase 1784 61.7 Moderate candidate 0.5163 ProteomeLM contextual shift 0.104465924 1.0 397 1.0 0 0 0.0 0.778 77.8 0.125 0.835 cell wall, synthase ProteomeLM contextual percentile 0.52; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: cell wall, synthase /main_page_ml/ML0101 2026-05-30T13:09:52Z 1008 ML1055 Q49945 ML1055 u1756c; ML1181 MLCB1701.07c Putative ESAT-6-like protein Y 100 61.692 Moderate candidate 0.6059 ProteomeLM contextual shift 0.118013814 1.0 14 1.0 322 44 0.8592 0.7911 79.11 0.0 0.7575 ProteomeLM contextual percentile 0.61; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML1055 2026-05-30T13:09:52Z 1009 ML2663 Q7APS6 oxyS ML2663 Probable hydrogen peroxide-inducible genes activator 310 61.673 Moderate candidate 0.4818 ProteomeLM contextual shift 0.101173446 1.0 75 1.0 990 0 0.4792 0.8684 86.84 0.125 0.8625 transcription ProteomeLM contextual percentile 0.48; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: transcription /main_page_ml/ML2663 2026-05-30T13:09:52Z 1010 ML0826 Q9CCG4 glyS glyQS ML0826 Glycine--tRNA ligase (EC 6.1.1.14) (Glycyl-tRNA synthetase) (GlyRS) 463 61.618 Moderate candidate 0.1704 ProteomeLM contextual shift 0.06306579 1.0 130 1.0 1416 54 0.8775 0.9254 92.54 0.57 1.0 6.1.1.14 aminoacyl-trna, trna ligase, ligase, synthetase ProteomeLM contextual percentile 0.17; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model; matched: aminoacyl-trna, trna ligase, ligase, synthetase /main_page_ml/ML0826 2026-05-30T13:09:52Z 1011 ML0012 Q9CDE8 ML0012 Membrane protein 137 61.599 Moderate candidate 0.5614 ProteomeLM contextual shift 0.110563986 1.0 24 1.0 304 60 0.943 0.8324 83.24 0.0 0.8625 ProteomeLM contextual percentile 0.56; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML0012 2026-05-30T13:09:52Z 1012 ML1704 Q9CBR7 ML1704 ACT domain-containing protein 232 61.566 Moderate candidate 0.5733 ProteomeLM contextual shift 0.11275536 1.0 24 1.0 721 50 0.7799 0.7875 78.75 0.0 0.8625 ProteomeLM contextual percentile 0.57; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML1704 2026-05-30T13:09:52Z 1013 ML0756 Q9CCK4 ML0756 site-specific DNA-methyltransferase (adenine-specific) (EC 2.1.1.72) 555 61.558 Moderate candidate 0.3127 ProteomeLM contextual shift 0.08050674 1.0 60 1.0 1687 4 0.5833 0.8415 84.15 0.36 1.0 2.1.1.72 transferase ProteomeLM contextual percentile 0.31; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model; matched: transferase /main_page_ml/ML0756 2026-05-30T13:09:52Z 1014 ML1220 P46715 bioB ML1220 B1170_C3_228 Biotin synthase (EC 2.8.1.6) 345 61.545 Moderate candidate 0.1122 ProteomeLM contextual shift 0.050253853 1.0 66 1.0 732 84 0.9819 0.8919 89.19 0.685 1.0 2.8.1.6 PATHWAY: Cofactor biosynthesis; biotin biosynthesis; biotin from 7,8-diaminononanoate: step 2/2. {ECO:0000255|HAMAP-Rule:MF_01694}. cofactor biosynthesis, synthase, cofactor ProteomeLM contextual percentile 0.11; strong pocket/AF2Bind evidence; essential-process annotation; high-confidence Boltz2 model; matched: cofactor biosynthesis, synthase, cofactor /main_page_ml/ML1220 2026-05-30T13:09:52Z 1015 ML2074 Q7APZ5 ML2074 BFN domain-containing protein 164 61.503 Moderate candidate 0.5207 ProteomeLM contextual shift 0.10489357 1.0 28 1.0 336 16 0.8736 0.8054 80.54 0.08 0.8625 ProteomeLM contextual percentile 0.52; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML2074 2026-05-30T13:09:52Z 1016 ML2557 Q7APU6 ML2557 Uncharacterized protein 98 61.493 Moderate candidate 0.6441 ProteomeLM contextual shift 0.12422757 1.0 12 1.0 313 38 0.8798 0.6374 63.74 0.0 0.7575 ProteomeLM contextual percentile 0.64; strong pocket/AF2Bind evidence /main_page_ml/ML2557 2026-05-30T13:09:52Z 1017 ML0018 Q9CDE6 pbpA ML0018 Peptidoglycan D,D-transpeptidase PbpA (EC 3.4.16.4) (Penicillin-binding protein A) 492 61.467 Moderate candidate 0.1253 ProteomeLM contextual shift 0.05416477 1.0 54 1.0 1517 2 0.5038 0.8981 89.81 0.655 1.0 3.4.16.4 PATHWAY: Cell wall biogenesis; peptidoglycan biosynthesis. {ECO:0000256|ARBA:ARBA00004752}.; PATHWAY: Glycan biosynthesis. {ECO:0000256|ARBA:ARBA00060592}. peptidoglycan, cell wall, d-alanine ProteomeLM contextual percentile 0.13; strong pocket/AF2Bind evidence; essential-process annotation; high-confidence Boltz2 model; matched: peptidoglycan, cell wall, d-alanine /main_page_ml/ML0018 2026-05-30T13:09:52Z 1018 ML2421 Q49808 hemC ML2421 B2168_C1_179 B2168_C3_262 Porphobilinogen deaminase (PBG) (EC 2.5.1.61) (Hydroxymethylbilane synthase) (HMBS) (Pre-uroporphyrinogen synthase) 315 61.438 Moderate candidate 0.2061 ProteomeLM contextual shift 0.06706163 1.0 36 1.0 1000 92 0.9694 0.8823 88.23 0.52 1.0 2.5.1.61 PATHWAY: Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 2/4. synthase, cofactor ProteomeLM contextual percentile 0.21; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model; matched: synthase, cofactor /main_page_ml/ML2421 2026-05-30T13:09:52Z 1019 ML1952 Q7AQ11 desA2 ML1952 Acyl-[ACP] desaturase 275 61.415 Moderate candidate 0.3672 ProteomeLM contextual shift 0.08839083 1.0 70 1.0 847 44 0.8261 0.9564 95.64 0.2 1.0 cofactor ProteomeLM contextual percentile 0.37; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: cofactor /main_page_ml/ML1952 2026-05-30T13:09:52Z 1020 ML0877 Q9CCE9 mmpS3 ML0877 Probable transport accessory protein MmpS3 293 61.414 Moderate candidate 0.6203 ProteomeLM contextual shift 0.120195135 1.0 22 1.0 902 6 0.6268 0.4478 44.78 0.08 0.8625 ProteomeLM contextual percentile 0.62; strong pocket/AF2Bind evidence /main_page_ml/ML0877 2026-05-30T13:09:52Z 1021 ML1338 Q7AQ64 ML1338 Possible conserved integral membrane protein 440 61.404 Moderate candidate 0.4618 ProteomeLM contextual shift 0.09912686 1.0 85 1.0 1363 6 0.5227 0.8642 86.42 0.08 1.0 transferase ProteomeLM contextual percentile 0.46; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: transferase /main_page_ml/ML1338 2026-05-30T13:09:52Z 1022 ML1843 O32999 rplR ML1843 MLCB2492.20 Large ribosomal subunit protein uL18 (50S ribosomal protein L18) 122 61.401 Moderate candidate 0.4223 ProteomeLM contextual shift 0.09472908 1.0 10 1.0 410 94 0.9663 0.8695 86.95 0.215 0.8625 translation, ribosome, ribosomal ProteomeLM contextual percentile 0.42; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: translation, ribosome, ribosomal /main_page_ml/ML1843 2026-05-30T13:09:52Z 1023 ML1633 Q9CBT1 ML1633 Possible secreted hydrolase 535 61.388 Moderate candidate 0.4649 ProteomeLM contextual shift 0.09954934 1.0 62 1.0 1696 182 0.9667 0.8516 85.16 0.08 1.0 hydrolase ProteomeLM contextual percentile 0.46; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: hydrolase /main_page_ml/ML1633 2026-05-30T13:09:52Z 1024 ML1596 O33040 amiC ML1596 MLCB250.65 Putative amidase AmiC (EC 3.5.1.4) 468 61.368 Moderate candidate 0.2036 ProteomeLM contextual shift 0.06670889 1.0 78 1.0 1460 112 0.9617 0.9641 96.41 0.48 1.0 3.5.1.4 ProteomeLM contextual percentile 0.20; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model /main_page_ml/ML1596 2026-05-30T13:09:52Z 1025 ML0475 Q49645 ML0475 B1177_C2_181 u1177b Probable transcriptional regulatory protein ML0475 251 61.362 Moderate candidate 0.4825 ProteomeLM contextual shift 0.10117917 1.0 26 1.0 804 102 0.9707 0.8351 83.51 0.125 0.8625 transcription ProteomeLM contextual percentile 0.48; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: transcription /main_page_ml/ML0475 2026-05-30T13:09:52Z 1026 ML2600 Q9CD04 ML2600 Probable conserved membrane protein 465 61.334 Moderate candidate 0.5157 ProteomeLM contextual shift 0.10445819 1.0 64 1.0 1437 4 0.6297 0.8061 80.61 0.08 0.8625 ProteomeLM contextual percentile 0.52; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML2600 2026-05-30T13:09:52Z 1027 ML1536 Q9CBV5 ML1536 AAA+ ATPase domain-containing protein 610 61.32 Moderate candidate 0.4994 ProteomeLM contextual shift 0.10267831 1.0 80 1.0 1890 0 0.4502 0.8617 86.17 0.08 0.8625 ProteomeLM contextual percentile 0.50; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML1536 2026-05-30T13:09:52Z 1028 ML2550 Q9CD25 ML2550 Carboxyltransferase domain-containing protein 305 61.309 Moderate candidate 0.448 ProteomeLM contextual shift 0.09738997 1.0 54 1.0 919 8 0.5949 0.903 90.3 0.08 1.0 transferase, hydrolase ProteomeLM contextual percentile 0.45; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: transferase, hydrolase /main_page_ml/ML2550 2026-05-30T13:09:52Z 1029 ML2489 Q9CB27 ML2489 Possible secreted protein 286 61.277 Moderate candidate 0.5858 ProteomeLM contextual shift 0.11525402 1.0 32 1.0 882 8 0.7033 0.7147 71.47 0.0 0.8625 ProteomeLM contextual percentile 0.59; strong pocket/AF2Bind evidence /main_page_ml/ML2489 2026-05-30T13:09:52Z 1030 ML0879 P15878 qcrB mla12A ML0879 Cytochrome bc1 complex cytochrome b subunit (EC 7.1.1.8) (Cytochrome bc1 reductase complex subunit QcrB) (Ubiquinol--cytochrome c reductase cytochrome b subunit) 551 61.211 Moderate candidate 0.2469 ProteomeLM contextual shift 0.07199016 1.0 126 1.0 1682 18 0.6906 0.7071 70.71 0.525 1.0 7.1.1.8 respiratory, oxidoreductase, reductase, cofactor ProteomeLM contextual percentile 0.25; strong pocket/AF2Bind evidence; functional annotation support; matched: respiratory, oxidoreductase, reductase, cofactor /main_page_ml/ML0879 2026-05-30T13:09:52Z 1031 ML1471 Q9CBY8 folC ML1471 Dihydrofolate synthase/folylpolyglutamate synthase (EC 6.3.2.12) (EC 6.3.2.17) (Tetrahydrofolylpolyglutamate synthase) 485 61.204 Moderate candidate 0.1429 ProteomeLM contextual shift 0.058205236 1.0 50 1.0 1510 110 0.9484 0.9004 90.04 0.61 1.0 6.3.2.12; 6.3.2.17 PATHWAY: Cofactor biosynthesis; tetrahydrofolate biosynthesis; 7,8-dihydrofolate from 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate and 4-aminobenzoate: step 2/2. {ECO:0000256|ARBA:ARBA00004799}.; PATHWAY: Cofactor biosynthesis; tetrahydrofolylpolyglutamate biosynthesis. {ECO:0000256|ARBA:ARBA00005150}. folate, cofactor biosynthesis, synthase, cofactor ProteomeLM contextual percentile 0.14; strong pocket/AF2Bind evidence; essential-process annotation; high-confidence Boltz2 model; matched: folate, cofactor biosynthesis, synthase, cofactor /main_page_ml/ML1471 2026-05-30T13:09:52Z 1032 ML1904 Q9CBK2 rplA ML1904 Large ribosomal subunit protein uL1 (50S ribosomal protein L1) 235 61.193 Moderate candidate 0.4167 ProteomeLM contextual shift 0.09385775 1.0 18 1.0 753 96 0.9199 0.8685 86.85 0.215 0.8625 translation, ribosome, ribosomal ProteomeLM contextual percentile 0.42; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: translation, ribosome, ribosomal /main_page_ml/ML1904 2026-05-30T13:09:52Z 1033 ML0118 Q9CD96 ML0118 Oxidireductase 336 61.181 Moderate candidate 0.4066 ProteomeLM contextual shift 0.09305819 1.0 56 1.0 1068 120 0.974 0.9449 94.49 0.125 1.0 nad, oxidoreductase, reductase ProteomeLM contextual percentile 0.41; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: nad, oxidoreductase, reductase /main_page_ml/ML0118 2026-05-30T13:09:52Z 1034 ML2507 Q9CB17 dcd ML2507 dCTP deaminase, dUMP-forming (EC 3.5.4.30) (Bifunctional dCTP deaminase:dUTPase) (DCD-DUT) 190 61.159 Moderate candidate 0.1234 ProteomeLM contextual shift 0.05373777 1.0 70 1.0 406 52 0.9706 0.9039 90.39 0.64 1.0 3.5.4.30 PATHWAY: Pyrimidine metabolism; dUMP biosynthesis; dUMP from dCTP: step 1/1. {ECO:0000255|HAMAP-Rule:MF_00146}. ProteomeLM contextual percentile 0.12; strong pocket/AF2Bind evidence; essential-process annotation; high-confidence Boltz2 model /main_page_ml/ML2507 2026-05-30T13:09:52Z 1035 ML0865 O32955 gcvT ML0865 MLCB22.13c Aminomethyltransferase (EC 2.1.2.10) (Glycine cleavage system T protein) 367 61.139 Moderate candidate 0.2425 ProteomeLM contextual shift 0.071230374 1.0 42 1.0 1173 144 0.9943 0.9553 95.53 0.405 1.0 2.1.2.10 folate, transferase ProteomeLM contextual percentile 0.24; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model; matched: folate, transferase /main_page_ml/ML0865 2026-05-30T13:09:52Z 1036 ML2583 Q7APT7 ML2583 Glycosyl transferase 394 61.077 Moderate candidate 0.4398 ProteomeLM contextual shift 0.09663775 1.0 42 1.0 1265 166 0.9638 0.9082 90.82 0.08 1.0 transferase ProteomeLM contextual percentile 0.44; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: transferase /main_page_ml/ML2583 2026-05-30T13:09:52Z 1037 ML0989 Q49842 miaB ML0989 B2235_C2_195 tRNA-2-methylthio-N(6)-dimethylallyladenosine synthase (EC 2.8.4.3) ((Dimethylallyl)adenosine tRNA methylthiotransferase MiaB) (tRNA-i(6)A37 methylthiotransferase) 517 61.059 Moderate candidate 0.2318 ProteomeLM contextual shift 0.070217095 1.0 72 1.0 1622 142 0.9388 0.8345 83.45 0.48 1.0 2.8.4.3 transferase, synthase, cofactor ProteomeLM contextual percentile 0.23; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model; matched: transferase, synthase, cofactor /main_page_ml/ML0989 2026-05-30T13:09:52Z 1038 ML1174 P37939 rph rnpH rphA ML1174 B1549_C1_182 Ribonuclease PH (RNase PH) (EC 2.7.7.56) (tRNA nucleotidyltransferase) 259 61.039 Moderate candidate 0.2068 ProteomeLM contextual shift 0.067160554 1.0 228 1.0 793 32 0.8026 0.9202 92.02 0.48 1.0 2.7.7.56 transferase ProteomeLM contextual percentile 0.21; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model; matched: transferase /main_page_ml/ML1174 2026-05-30T13:09:52Z 1039 ML2624 O06084 pckG pckA ML2624 MLCL622.21 Phosphoenolpyruvate carboxykinase [GTP] (PEP carboxykinase) (PEPCK) (EC 4.1.1.32) 609 60.997 Moderate candidate 0.1059 ProteomeLM contextual shift 0.049388025 1.0 104 1.0 1833 12 0.6251 0.9491 94.91 0.64 1.0 4.1.1.32 PATHWAY: Carbohydrate biosynthesis; gluconeogenesis. {ECO:0000255|HAMAP-Rule:MF_00452}. kinase, cofactor ProteomeLM contextual percentile 0.11; strong pocket/AF2Bind evidence; essential-process annotation; high-confidence Boltz2 model; matched: kinase, cofactor /main_page_ml/ML2624 2026-05-30T13:09:52Z 1040 ML1845 O32997 rpsH ML1845 MLCB2492.18 Small ribosomal subunit protein uS8 (30S ribosomal protein S8) 132 60.992 Moderate candidate 0.3929 ProteomeLM contextual shift 0.09194831 1.0 8 1.0 403 14 0.559 0.9317 93.17 0.215 0.8625 translation, ribosome, ribosomal ProteomeLM contextual percentile 0.39; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: translation, ribosome, ribosomal /main_page_ml/ML1845 2026-05-30T13:09:52Z 1041 ML2082 O32922 secA2 ML2082 MLCB1788.45c Protein translocase subunit SecA 2 (EC 7.4.2.8) 778 60.976 Moderate candidate 0.2563 ProteomeLM contextual shift 0.07399713 1.0 158 1.0 2376 4 0.5793 0.8157 81.57 0.48 0.925 7.4.2.8 ProteomeLM contextual percentile 0.26; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model /main_page_ml/ML2082 2026-05-30T13:09:52Z 1042 ML1063 P0C0X2 folP2 ML1063 Inactive dihydropteroate synthase 2 (DHPS 2) (Dihydropteroate pyrophosphorylase 2) 291 60.964 Moderate candidate 0.4298 ProteomeLM contextual shift 0.09531881 1.0 80 1.0 927 108 0.9847 0.9321 93.21 0.08 1.0 synthase ProteomeLM contextual percentile 0.43; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: synthase /main_page_ml/ML1063 2026-05-30T13:09:52Z 1043 ML2269 Q9CBB1 ML2269 Hydrolase 265 60.959 Moderate candidate 0.4254 ProteomeLM contextual shift 0.09499858 1.0 52 1.0 886 182 0.9979 0.9469 94.69 0.08 1.0 hydrolase ProteomeLM contextual percentile 0.43; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: hydrolase /main_page_ml/ML2269 2026-05-30T13:09:52Z 1044 ML0032 Q50192 leuS ML0032 MLB1770.20 MLCB628.03 Leucine--tRNA ligase (EC 6.1.1.4) (Leucyl-tRNA synthetase) (LeuRS) 972 60.952 Moderate candidate 0.1836 ProteomeLM contextual shift 0.06417507 1.0 176 1.0 2976 0 0.2681 0.8877 88.77 0.57 0.925 6.1.1.4 aminoacyl-trna, trna ligase, ligase, synthetase ProteomeLM contextual percentile 0.18; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model; matched: aminoacyl-trna, trna ligase, ligase, synthetase /main_page_ml/ML0032 2026-05-30T13:09:52Z 1045 ML1245 Q7AQ81 ML1245 Possible transferase 579 60.944 Moderate candidate 0.4862 ProteomeLM contextual shift 0.10145641 1.0 84 1.0 1799 124 0.9672 0.7326 73.26 0.08 1.0 transferase, hydrolase ProteomeLM contextual percentile 0.49; strong pocket/AF2Bind evidence; matched: transferase, hydrolase /main_page_ml/ML1245 2026-05-30T13:09:52Z 1046 ML1022 Q7AQB1 rpoT sigA ML1022 RNA polymerase sigma factor SigA 574 60.943 Moderate candidate 0.5495 ProteomeLM contextual shift 0.10930006 1.0 82 1.0 1153 10 0.5519 0.4686 46.86 0.17 0.8625 rna polymerase, transcription ProteomeLM contextual percentile 0.55; strong pocket/AF2Bind evidence; matched: rna polymerase, transcription /main_page_ml/ML1022 2026-05-30T13:09:52Z 1047 ML0706 Q9CCL7 pmmB ML0706 Phospho-sugar mutase 538 60.928 Moderate candidate 0.4279 ProteomeLM contextual shift 0.09524772 1.0 197 1.0 1082 12 0.6513 0.935 93.5 0.08 1.0 cofactor ProteomeLM contextual percentile 0.43; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: cofactor /main_page_ml/ML0706 2026-05-30T13:09:52Z 1048 ML2136 O33062 serC ML2136 MLCB57.37c Putative phosphoserine aminotransferase (EC 2.6.1.52) (Phosphohydroxythreonine aminotransferase) (PSAT) 376 60.869 Moderate candidate 0.0727 ProteomeLM contextual shift 0.040858 1.0 82 1.0 1140 24 0.6229 0.9625 96.25 0.685 1.0 2.6.1.52 PATHWAY: Amino-acid biosynthesis; L-serine biosynthesis; L-serine from 3-phospho-D-glycerate: step 2/3. {ECO:0000255|HAMAP-Rule:MF_00160}.; PATHWAY: Cofactor biosynthesis; pyridoxine 5'-phosphate biosynthesis; pyridoxine 5'-phosphate from D-erythrose 4-phosphate: step 3/5. {ECO:0000255|HAMAP-Rule:MF_00160}. cofactor biosynthesis, transferase, cofactor ProteomeLM contextual percentile 0.07; strong pocket/AF2Bind evidence; essential-process annotation; high-confidence Boltz2 model; matched: cofactor biosynthesis, transferase, cofactor /main_page_ml/ML2136 2026-05-30T13:09:52Z 1049 ML0294 Q9ZBL0 thiC ML0294 MLCB1450.28c Phosphomethylpyrimidine synthase (EC 4.1.99.17) (Hydroxymethylpyrimidine phosphate synthase) (HMP-P synthase) (HMP-phosphate synthase) (HMPP synthase) (Thiamine biosynthesis protein ThiC) 547 60.854 Moderate candidate 0.0883 ProteomeLM contextual shift 0.04557423 1.0 106 1.0 1117 46 0.8935 0.9062 90.62 0.685 1.0 4.1.99.17 PATHWAY: Cofactor biosynthesis; thiamine diphosphate biosynthesis. {ECO:0000255|HAMAP-Rule:MF_00089}. cofactor biosynthesis, synthase, cofactor ProteomeLM contextual percentile 0.09; strong pocket/AF2Bind evidence; essential-process annotation; high-confidence Boltz2 model; matched: cofactor biosynthesis, synthase, cofactor /main_page_ml/ML0294 2026-05-30T13:09:52Z 1050 ML0902 Q7AQC9 ML0902 Probable lipoprotein 239 60.835 Moderate candidate 0.5783 ProteomeLM contextual shift 0.11407205 1.0 22 1.0 486 16 0.7673 0.6969 69.69 0.0 0.8625 ProteomeLM contextual percentile 0.58; strong pocket/AF2Bind evidence /main_page_ml/ML0902 2026-05-30T13:09:52Z 1051 ML1358 Q7AQ61 tlyA ML1358 Cytotoxin/hemolysin 269 60.824 Moderate candidate 0.4411 ProteomeLM contextual shift 0.096750334 1.0 30 1.0 883 152 0.9687 0.8785 87.85 0.08 1.0 transferase ProteomeLM contextual percentile 0.44; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: transferase /main_page_ml/ML1358 2026-05-30T13:09:52Z 1052 ML1486 Q9CBX9 ML1486 Aminopeptidase N (EC 3.4.11.2) (Alanine aminopeptidase) (Lysyl aminopeptidase) 862 60.814 Moderate candidate 0.282 ProteomeLM contextual shift 0.07748785 1.0 182 1.0 2595 18 0.6029 0.9496 94.96 0.36 0.925 3.4.11.2 cofactor ProteomeLM contextual percentile 0.28; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model; matched: cofactor /main_page_ml/ML1486 2026-05-30T13:09:52Z 1053 ML1093 Q9CC99 ML1093 Lipoprotein 285 60.799 Moderate candidate 0.4781 ProteomeLM contextual shift 0.100827955 1.0 42 1.0 884 58 0.8252 0.8841 88.41 0.08 0.8625 ProteomeLM contextual percentile 0.48; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML1093 2026-05-30T13:09:52Z 1054 ML1681 O33127 ppk ML1681 MLCB637.36c Polyphosphate kinase (EC 2.7.4.1) (ATP-polyphosphate phosphotransferase) (Polyphosphoric acid kinase) 739 60.794 Moderate candidate 0.2149 ProteomeLM contextual shift 0.06782291 1.0 206 1.0 2252 30 0.8238 0.8672 86.72 0.48 1.0 2.7.4.1 kinase, transferase, cofactor ProteomeLM contextual percentile 0.21; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model; matched: kinase, transferase, cofactor /main_page_ml/ML1681 2026-05-30T13:09:52Z 1055 ML1113 Q9CC89 ML1113 Fatty acid ABC transporter ATP-binding/permease protein 629 60.787 Moderate candidate 0.5251 ProteomeLM contextual shift 0.10591945 1.0 158 1.0 1920 66 0.9685 0.7184 71.84 0.08 0.8625 ProteomeLM contextual percentile 0.53; strong pocket/AF2Bind evidence /main_page_ml/ML1113 2026-05-30T13:09:52Z 1056 ML0109 Q9CDA4 ML0109 FAD-linked oxidoreductase 460 60.749 Moderate candidate 0.433 ProteomeLM contextual shift 0.095769316 1.0 48 1.0 1489 218 0.9815 0.8995 89.95 0.08 1.0 oxidoreductase, reductase ProteomeLM contextual percentile 0.43; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: oxidoreductase, reductase /main_page_ml/ML0109 2026-05-30T13:09:52Z 1057 ML0466 Q7AQI8 ML0466 Possible secreted protein 301 60.733 Moderate candidate 0.5683 ProteomeLM contextual shift 0.11181479 1.0 44 1.0 978 150 0.9962 0.7217 72.17 0.0 0.8625 ProteomeLM contextual percentile 0.57; strong pocket/AF2Bind evidence /main_page_ml/ML0466 2026-05-30T13:09:52Z 1058 ML0985 Q7AQB9 ML0985 Possible glycosyltransferase 392 60.723 Moderate candidate 0.4342 ProteomeLM contextual shift 0.09589576 1.0 60 1.0 1294 236 0.9967 0.8926 89.26 0.08 1.0 transferase ProteomeLM contextual percentile 0.43; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: transferase /main_page_ml/ML0985 2026-05-30T13:09:52Z 1059 ML1289 Q9CC45 ML1289 Uncharacterized protein 176 60.621 Moderate candidate 0.5025 ProteomeLM contextual shift 0.10332452 1.0 104 1.0 537 18 0.6804 0.9408 94.08 0.0 0.8625 ProteomeLM contextual percentile 0.50; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML1289 2026-05-30T13:09:52Z 1060 ML1017 Q7AQB2 ML1017 Possible conserved integral membrane protein 330 60.619 Moderate candidate 0.5432 ProteomeLM contextual shift 0.10820806 1.0 84 1.0 1072 164 0.9944 0.6381 63.81 0.08 0.8625 ProteomeLM contextual percentile 0.54; strong pocket/AF2Bind evidence /main_page_ml/ML1017 2026-05-30T13:09:52Z 1061 ML0524 Q9CCR8 adi ML0524 Amino acid decarboxylase 950 60.609 Moderate candidate 0.4543 ProteomeLM contextual shift 0.09800184 1.0 256 1.0 2910 0 0.2845 0.886 88.6 0.08 0.925 cofactor ProteomeLM contextual percentile 0.45; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: cofactor /main_page_ml/ML0524 2026-05-30T13:09:52Z 1062 ML0590 Q7AQH8 ML0590 ABC transporter ATP-binding protein 315 60.599 Moderate candidate 0.4812 ProteomeLM contextual shift 0.10108982 1.0 46 1.0 971 52 0.9044 0.8532 85.32 0.08 0.8625 ProteomeLM contextual percentile 0.48; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML0590 2026-05-30T13:09:52Z 1063 ML0016 P54744 pknB ML0016 Serine/threonine-protein kinase PknB (EC 2.7.11.1) 622 60.596 Moderate candidate 0.2456 ProteomeLM contextual shift 0.07174984 1.0 91 1.0 1888 4 0.5736 0.7399 73.99 0.48 1.0 2.7.11.1 kinase ProteomeLM contextual percentile 0.25; strong pocket/AF2Bind evidence; functional annotation support; matched: kinase /main_page_ml/ML0016 2026-05-30T13:09:52Z 1064 ML0021 Q7AQP5 ML0021 FHA domain-containing protein FhaB (FtsZ-interacting protein A) 155 60.585 Moderate candidate 0.4461 ProteomeLM contextual shift 0.097304806 1.0 47 1.0 864 38 0.9812 0.7946 79.46 0.17 0.8625 ftsz, fts ProteomeLM contextual percentile 0.45; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: ftsz, fts /main_page_ml/ML0021 2026-05-30T13:09:52Z 1065 ML1003 Q49848 lexA ML1003 B2235_F2_55 LexA repressor (EC 3.4.21.88) 235 60.517 Moderate candidate 0.1974 ProteomeLM contextual shift 0.06599146 1.0 50 1.0 753 96 0.9088 0.631 63.1 0.615 1.0 3.4.21.88 dna replication, replication, transcription ProteomeLM contextual percentile 0.20; strong pocket/AF2Bind evidence; essential-process annotation; matched: dna replication, replication, transcription /main_page_ml/ML1003 2026-05-30T13:09:52Z 1066 ML2228 Q7APX3 ML2228 Transmembrane protein 206 60.478 Moderate candidate 0.5545 ProteomeLM contextual shift 0.109812744 1.0 16 1.0 678 0 0.4677 0.7445 74.45 0.0 0.8625 ProteomeLM contextual percentile 0.55; strong pocket/AF2Bind evidence /main_page_ml/ML2228 2026-05-30T13:09:52Z 1067 ML2327 Q7APW5 gatD ML2327 Lipid II isoglutaminyl synthase (glutamine-hydrolyzing) subunit GatD (EC 6.3.5.13) (Lipid II isoglutaminyl synthase glutaminase subunit) (EC 3.5.1.2) 230 60.465 Moderate candidate 0.0132 ProteomeLM contextual shift 0.015005287 1.0 20 1.0 700 20 0.8374 0.9504 95.04 0.775 1.0 3.5.1.2; 6.3.5.13 PATHWAY: Cell wall biogenesis; peptidoglycan biosynthesis. {ECO:0000256|HAMAP-Rule:MF_02213}. peptidoglycan, cell wall, mur, ligase, synthase ProteomeLM contextual percentile 0.01; strong pocket/AF2Bind evidence; essential-process annotation; high-confidence Boltz2 model; matched: peptidoglycan, cell wall, mur, ligase, synthase /main_page_ml/ML2327 2026-05-30T13:09:52Z 1068 ML0544 Q9CCQ4 metK ML0544 S-adenosylmethionine synthase (AdoMet synthase) (EC 2.5.1.6) (MAT) (Methionine adenosyltransferase) 403 60.418 Moderate candidate 0.0896 ProteomeLM contextual shift 0.045791574 1.0 161 1.0 846 0 0.4069 0.9482 94.82 0.64 1.0 2.5.1.6 PATHWAY: Amino-acid biosynthesis; S-adenosyl-L-methionine biosynthesis; S-adenosyl-L-methionine from L-methionine: step 1/1. {ECO:0000255|HAMAP-Rule:MF_00086}. transferase, synthase, cofactor ProteomeLM contextual percentile 0.09; strong pocket/AF2Bind evidence; essential-process annotation; high-confidence Boltz2 model; matched: transferase, synthase, cofactor /main_page_ml/ML0544 2026-05-30T13:09:52Z 1069 ML1723 Q9CBQ9 ML1723 Methyltransferase type 11 domain-containing protein 327 60.413 Moderate candidate 0.4236 ProteomeLM contextual shift 0.094868846 1.0 80 1.0 1087 212 0.994 0.8988 89.88 0.08 1.0 transferase ProteomeLM contextual percentile 0.42; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: transferase /main_page_ml/ML1723 2026-05-30T13:09:52Z 1070 ML2689 Q7APR8 ML2689 DUF5318 domain-containing protein 138 60.381 Moderate candidate 0.5194 ProteomeLM contextual shift 0.104708806 1.0 22 1.0 439 50 0.8261 0.8576 85.76 0.0 0.8625 ProteomeLM contextual percentile 0.52; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML2689 2026-05-30T13:09:52Z 1071 ML1707 O33099 mnmA trmU ML1707 MLCB637.07 tRNA-specific 2-thiouridylase MnmA (EC 2.8.1.13) 358 60.375 Moderate candidate 0.1967 ProteomeLM contextual shift 0.06583511 1.0 62 1.0 1139 130 0.9848 0.8889 88.89 0.48 1.0 2.8.1.13 transferase ProteomeLM contextual percentile 0.20; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model; matched: transferase /main_page_ml/ML1707 2026-05-30T13:09:52Z 1072 ML2279 Q9CBA3 ML2279 Transmembrane transport protein 496 60.351 Moderate candidate 0.4944 ProteomeLM contextual shift 0.102348655 1.0 118 1.0 1509 42 0.9509 0.7823 78.23 0.08 0.8625 ProteomeLM contextual percentile 0.49; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML2279 2026-05-30T13:09:52Z 1073 ML1804 Q9CBM3 ML1804 Uncharacterized protein ML1804 298 60.347 Moderate candidate 0.5269 ProteomeLM contextual shift 0.10605263 1.0 48 1.0 924 60 0.9619 0.8279 82.79 0.0 0.8625 ProteomeLM contextual percentile 0.53; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML1804 2026-05-30T13:09:52Z 1074 ML0304 P57993 pknG ML0304 MLCB1450.19c Serine/threonine-protein kinase PknG (EC 2.7.11.1) 763 60.321 Moderate candidate 0.2419 ProteomeLM contextual shift 0.071098655 1.0 107 1.0 1557 6 0.6505 0.8006 80.06 0.48 0.925 2.7.11.1 kinase ProteomeLM contextual percentile 0.24; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model; matched: kinase /main_page_ml/ML0304 2026-05-30T13:09:52Z 1075 ML1371 Q49885 cmk ML1371 MLCB1351.02c Cytidylate kinase (CK) (EC 2.7.4.25) (Cytidine monophosphate kinase) (CMP kinase) 223 60.302 Moderate candidate 0.1961 ProteomeLM contextual shift 0.06567722 1.0 47 1.0 761 184 0.9898 0.8838 88.38 0.48 1.0 2.7.4.25 kinase ProteomeLM contextual percentile 0.20; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model; matched: kinase /main_page_ml/ML1371 2026-05-30T13:09:52Z 1076 ML0674 O32879 folD ML0674 Bifunctional protein FolD [Includes: Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)] 282 60.275 Moderate candidate 0.0407 ProteomeLM contextual shift 0.02972963 1.0 90 1.0 915 138 0.9755 0.9249 92.49 0.73 1.0 1.5.1.5; 3.5.4.9 PATHWAY: One-carbon metabolism; tetrahydrofolate interconversion. {ECO:0000255|HAMAP-Rule:MF_01576}. folate, nad, hydrolase, dehydrogenase ProteomeLM contextual percentile 0.04; strong pocket/AF2Bind evidence; essential-process annotation; high-confidence Boltz2 model; matched: folate, nad, hydrolase, dehydrogenase /main_page_ml/ML0674 2026-05-30T13:09:52Z 1077 ML1091 P50917 mdh ML1091 Malate dehydrogenase (EC 1.1.1.37) 329 60.226 Moderate candidate 0.1485 ProteomeLM contextual shift 0.05905908 1.0 90 1.0 697 78 0.9282 0.9529 95.29 0.525 1.0 1.1.1.37 nad, dehydrogenase ProteomeLM contextual percentile 0.15; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model; matched: nad, dehydrogenase /main_page_ml/ML1091 2026-05-30T13:09:52Z 1078 ML0572 P46711 tpiA tpi ML0572 B1496_C1_127 Triosephosphate isomerase (TIM) (TPI) (EC 5.3.1.1) (Triose-phosphate isomerase) 261 60.199 Moderate candidate 0.0815 ProteomeLM contextual shift 0.04336385 1.0 58 1.0 827 88 0.9379 0.9548 95.48 0.64 1.0 5.3.1.1 PATHWAY: Carbohydrate biosynthesis; gluconeogenesis. {ECO:0000255|HAMAP-Rule:MF_00147}.; PATHWAY: Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate from glycerone phosphate: step 1/1. {ECO:0000255|HAMAP-Rule:MF_00147}. isomerase ProteomeLM contextual percentile 0.08; strong pocket/AF2Bind evidence; essential-process annotation; high-confidence Boltz2 model; matched: isomerase /main_page_ml/ML0572 2026-05-30T13:09:52Z 1079 ML1698 Q7AQ27 ML1698 Conserved membrane protein 277 60.173 Moderate candidate 0.5602 ProteomeLM contextual shift 0.110412106 1.0 38 1.0 859 16 0.6174 0.5343 53.43 0.08 0.8625 ProteomeLM contextual percentile 0.56; strong pocket/AF2Bind evidence /main_page_ml/ML1698 2026-05-30T13:09:52Z 1080 ML1059 Q9CCB0 dapE ML1059 Succinyl-diaminopimelate desuccinylase (EC 3.5.1.18) 354 60.147 Moderate candidate 0.1529 ProteomeLM contextual shift 0.05980875 1.0 52 1.0 1081 38 0.9541 0.9396 93.96 0.52 1.0 3.5.1.18 PATHWAY: Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; LL-2,6-diaminopimelate from (S)-tetrahydrodipicolinate (succinylase route): step 3/3. {ECO:0000256|ARBA:ARBA00005130}. cofactor ProteomeLM contextual percentile 0.15; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model; matched: cofactor /main_page_ml/ML1059 2026-05-30T13:09:52Z 1081 ML0208 Q7AQL7 ML0208 Membrane protein 113 60.142 Moderate candidate 0.6109 ProteomeLM contextual shift 0.11878448 1.0 22 1.0 360 42 0.8993 0.6186 61.86 0.0 0.7575 ProteomeLM contextual percentile 0.61; strong pocket/AF2Bind evidence /main_page_ml/ML0208 2026-05-30T13:09:52Z 1082 ML1715 Q9CBR3 ML1715 Transferase 438 60.139 Moderate candidate 0.4192 ProteomeLM contextual shift 0.09434862 1.0 108 1.0 1388 148 0.9863 0.8868 88.68 0.08 1.0 transferase ProteomeLM contextual percentile 0.42; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: transferase /main_page_ml/ML1715 2026-05-30T13:09:52Z 1083 ML2563 Q7APU4 fadE5 ML2563 Broad-specificity linear acyl-CoA dehydrogenase FadE5 (EC 1.3.8.1) (EC 1.3.8.7) (EC 1.3.8.8) (Long-chain-acyl-CoA dehydrogenase) (Medium-chain-acyl-CoA dehydrogenase) (Short-chain-acyl-CoA dehydrogenase) 611 60.09 Moderate candidate 0.1178 ProteomeLM contextual shift 0.052549183 1.0 206 1.0 1899 132 0.9672 0.9667 96.67 0.565 1.0 1.3.8.1; 1.3.8.7; 1.3.8.8 PATHWAY: Lipid metabolism; fatty acid metabolism. {ECO:0000256|ARBA:ARBA00004872}. lipid metabolism, dehydrogenase, cofactor ProteomeLM contextual percentile 0.12; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model; matched: lipid metabolism, dehydrogenase, cofactor /main_page_ml/ML2563 2026-05-30T13:09:52Z 1084 ML1702 O33105 gatA ML1702 MLCB637.13 Glutamyl-tRNA(Gln) amidotransferase subunit A (Glu-ADT subunit A) (EC 6.3.5.7) 497 60.076 Moderate candidate 0.1548 ProteomeLM contextual shift 0.0599812 1.0 68 1.0 1501 20 0.6296 0.9159 91.59 0.525 1.0 6.3.5.7 translation, transferase, synthase ProteomeLM contextual percentile 0.15; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model; matched: translation, transferase, synthase /main_page_ml/ML1702 2026-05-30T13:09:52Z 1085 ML0201 Q7AQM3 ML0201 Membrane protein 530 60.071 Moderate candidate 0.49 ProteomeLM contextual shift 0.10184557 1.0 153 1.0 1613 6 0.5286 0.7697 76.97 0.08 0.8625 ProteomeLM contextual percentile 0.49; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML0201 2026-05-30T13:09:52Z 1086 ML1253 Q9CC59 glbO ML1253 Group 2 truncated hemoglobin GlbO (Hemoglobin-like protein HbO) (Truncated hemoglobin) (TrHbO) 128 60.06 Moderate candidate 0.3371 ProteomeLM contextual shift 0.084141515 1.0 86 1.0 456 144 0.9943 0.9262 92.62 0.2 1.0 cofactor ProteomeLM contextual percentile 0.34; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: cofactor /main_page_ml/ML1253 2026-05-30T13:09:52Z 1087 ML2530 Q9CD34 ML2530 Possible DNA-binding protein 289 59.988 Moderate candidate 0.4624 ProteomeLM contextual shift 0.0991957 1.0 40 1.0 909 84 0.965 0.8579 85.79 0.08 0.8625 ProteomeLM contextual percentile 0.46; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML2530 2026-05-30T13:09:52Z 1088 ML1267 Q7AQ77 ML1267 Antiporter 364 59.956 Moderate candidate 0.458 ProteomeLM contextual shift 0.09853602 1.0 58 1.0 1105 26 0.7088 0.87 87.0 0.08 0.8625 ProteomeLM contextual percentile 0.46; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML1267 2026-05-30T13:09:52Z 1089 ML0187 Q9CD64 ML0187 Acetyltransferase 353 59.94 Moderate candidate 0.3991 ProteomeLM contextual shift 0.092323646 1.0 64 1.0 1106 94 0.9587 0.8471 84.71 0.125 1.0 transcription, transferase ProteomeLM contextual percentile 0.40; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: transcription, transferase /main_page_ml/ML0187 2026-05-30T13:09:52Z 1090 ML2123 Q50136 prrA ML2123 MLCB57.61c Transcriptional regulatory protein PrrA 233 59.927 Moderate candidate 0.4336 ProteomeLM contextual shift 0.09578902 1.0 39 1.0 759 0 0.447 0.8626 86.26 0.125 0.8625 transcription ProteomeLM contextual percentile 0.43; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: transcription /main_page_ml/ML2123 2026-05-30T13:09:52Z 1091 ML2263 Q9CBB5 menB ML2263 1,4-dihydroxy-2-naphthoyl-CoA synthase (DHNA-CoA synthase) (EC 4.1.3.36) 300 59.922 Moderate candidate 0.0714 ProteomeLM contextual shift 0.040305987 1.0 214 1.0 961 122 0.9835 0.8722 87.22 0.685 1.0 4.1.3.36 PATHWAY: Quinol/quinone metabolism; 1,4-dihydroxy-2-naphthoate biosynthesis; 1,4-dihydroxy-2-naphthoate from chorismate: step 6/7. {ECO:0000256|HAMAP-Rule:MF_01934}.; PATHWAY: Quinol/quinone metabolism; menaquinone biosynthesis. {ECO:0000256|HAMAP-Rule:MF_01934}. menaquinone, isomerase, synthase ProteomeLM contextual percentile 0.07; strong pocket/AF2Bind evidence; essential-process annotation; high-confidence Boltz2 model; matched: menaquinone, isomerase, synthase /main_page_ml/ML2263 2026-05-30T13:09:52Z 1092 ML0779 P57996 secA1 ML0779 Protein translocase subunit SecA 1 (EC 7.4.2.8) 940 59.91 Moderate candidate 0.2393 ProteomeLM contextual shift 0.07093098 1.0 335 1.0 2880 0 0.4812 0.7683 76.83 0.48 0.925 7.4.2.8 ProteomeLM contextual percentile 0.24; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model /main_page_ml/ML0779 2026-05-30T13:09:52Z 1093 ML1307 Q49775 metH ML1307 B2126_C1_157 MLCB2533.04 Methionine synthase (EC 2.1.1.13) (5-methyltetrahydrofolate--homocysteine methyltransferase) (Methionine synthase, vitamin-B12 dependent) (MS) 1206 59.906 Moderate candidate 0.109 ProteomeLM contextual shift 0.049940426 1.0 188 1.0 1226 0 0.3244 0.904 90.4 0.685 0.835 2.1.1.13 PATHWAY: Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-methionine from L-homocysteine (MetH route): step 1/1. folate, transferase, synthase, cofactor ProteomeLM contextual percentile 0.11; strong pocket/AF2Bind evidence; essential-process annotation; high-confidence Boltz2 model; matched: folate, transferase, synthase, cofactor /main_page_ml/ML1307 2026-05-30T13:09:52Z 1094 ML1127 P45840 argS ML1127 Arginine--tRNA ligase (EC 6.1.1.19) (Arginyl-tRNA synthetase) (ArgRS) 550 59.837 Moderate candidate 0.1905 ProteomeLM contextual shift 0.06521576 1.0 78 1.0 1676 52 0.8103 0.917 91.7 0.45 1.0 6.1.1.19 aminoacyl-trna, trna ligase, ligase, synthetase ProteomeLM contextual percentile 0.19; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model; matched: aminoacyl-trna, trna ligase, ligase, synthetase /main_page_ml/ML1127 2026-05-30T13:09:52Z 1095 ML2124 O33071 prrB ML2124 MLCB57.60c Sensor-type histidine kinase PrrB (EC 2.7.13.3) 446 59.829 Moderate candidate 0.2888 ProteomeLM contextual shift 0.07821779 1.0 100 1.0 913 2 0.5606 0.7519 75.19 0.36 1.0 2.7.13.3 kinase ProteomeLM contextual percentile 0.29; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model; matched: kinase /main_page_ml/ML2124 2026-05-30T13:09:52Z 1096 ML1129 P46806 hom ML1129 Homoserine dehydrogenase (HDH) (HSD) (EC 1.1.1.3) 441 59.823 Moderate candidate 0.0595 ProteomeLM contextual shift 0.037269298 1.0 116 1.0 1337 28 0.7297 0.904 90.4 0.685 1.0 1.1.1.3 PATHWAY: Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 3/3. {ECO:0000250|UniProtKB:P31116}.; PATHWAY: Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 3/5. {ECO:0000250|UniProtKB:P31116}. nad, enzyme, dehydrogenase, cofactor ProteomeLM contextual percentile 0.06; strong pocket/AF2Bind evidence; essential-process annotation; high-confidence Boltz2 model; matched: nad, enzyme, dehydrogenase, cofactor /main_page_ml/ML1129 2026-05-30T13:09:52Z 1097 ML0803 Q9CCH8 ML0803 histidine kinase (EC 2.7.13.3) 500 59.813 Moderate candidate 0.2857 ProteomeLM contextual shift 0.07786764 1.0 73 1.0 1005 10 0.5994 0.7613 76.13 0.36 1.0 2.7.13.3 kinase ProteomeLM contextual percentile 0.29; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model; matched: kinase /main_page_ml/ML0803 2026-05-30T13:09:52Z 1098 ML1116 Q9CC86 ML1116 Lipoprotein 187 59.767 Moderate candidate 0.5401 ProteomeLM contextual shift 0.107692696 1.0 20 1.0 401 54 0.8929 0.7239 72.39 0.0 0.8625 ProteomeLM contextual percentile 0.54; strong pocket/AF2Bind evidence /main_page_ml/ML1116 2026-05-30T13:09:52Z 1099 ML2069 O32913 glcB ML2069 MLCB1788.27 Malate synthase G (EC 2.3.3.9) 731 59.758 Moderate candidate 0.0683 ProteomeLM contextual shift 0.039378073 1.0 114 1.0 2900 66 0.781 0.9568 95.68 0.64 1.0 2.3.3.9 PATHWAY: Carbohydrate metabolism; glyoxylate cycle; (S)-malate from isocitrate: step 2/2. {ECO:0000255|HAMAP-Rule:MF_00641}. synthase, cofactor ProteomeLM contextual percentile 0.07; strong pocket/AF2Bind evidence; essential-process annotation; high-confidence Boltz2 model; matched: synthase, cofactor /main_page_ml/ML2069 2026-05-30T13:09:52Z 1100 ML1389 Q9CC27 ML1389 Conserved membrane protein 527 59.747 Moderate candidate 0.4204 ProteomeLM contextual shift 0.09442983 1.0 108 1.0 1591 20 0.6361 0.8432 84.32 0.08 1.0 transferase ProteomeLM contextual percentile 0.42; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: transferase /main_page_ml/ML1389 2026-05-30T13:09:52Z 1101 ML2546 Q9CD27 fadD2 ML2546 Long-chain-fatty-acid--CoA ligase FadD13 (EC 6.2.1.3) (Fatty acyl-CoA ligase) (Fatty acyl-CoA synthetase) (Very-long-chain fatty-acyl-CoA synthetase) 548 59.735 Moderate candidate 0.2475 ProteomeLM contextual shift 0.072067246 1.0 213 1.0 1721 154 0.9364 0.8872 88.72 0.36 1.0 6.2.1.3 enzyme, ligase, synthetase ProteomeLM contextual percentile 0.25; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model; matched: enzyme, ligase, synthetase /main_page_ml/ML2546 2026-05-30T13:09:52Z 1102 ML2631 Q7APS7 ML2631 Possible oxidoreductase 449 59.714 Moderate candidate 0.3653 ProteomeLM contextual shift 0.088021845 1.0 54 1.0 1408 122 0.9708 0.9429 94.29 0.125 1.0 respiratory, transferase, oxidoreductase, reductase ProteomeLM contextual percentile 0.37; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: respiratory, transferase, oxidoreductase, reductase /main_page_ml/ML2631 2026-05-30T13:09:52Z 1103 ML2326 Q7APW6 murT ML2326 Lipid II isoglutaminyl synthase (glutamine-hydrolyzing) subunit MurT (EC 6.3.5.13) 411 59.707 Moderate candidate 0.01 ProteomeLM contextual shift 0.011348288 1.0 52 1.0 1265 64 0.7553 0.8856 88.56 0.775 1.0 6.3.5.13 PATHWAY: Cell wall biogenesis; peptidoglycan biosynthesis. {ECO:0000256|HAMAP-Rule:MF_02214}. peptidoglycan, cell wall, mur, ligase, synthase ProteomeLM contextual percentile 0.01; strong pocket/AF2Bind evidence; essential-process annotation; high-confidence Boltz2 model; matched: peptidoglycan, cell wall, mur, ligase, synthase /main_page_ml/ML2326 2026-05-30T13:09:52Z 1104 ML1926 Q9CBI5 ML1926 Tuberculin related peptide (AT103) 167 59.682 Moderate candidate 0.5576 ProteomeLM contextual shift 0.110033035 1.0 12 1.0 537 72 0.9247 0.6539 65.39 0.0 0.8625 ProteomeLM contextual percentile 0.56; strong pocket/AF2Bind evidence /main_page_ml/ML1926 2026-05-30T13:09:52Z 1105 ML1177 P54134 lprD ML1177 B1549_F3_106 MLCB1701.03c Putative lipoprotein LprD 126 59.668 Moderate candidate 0.5376 ProteomeLM contextual shift 0.10748579 1.0 26 1.0 422 88 0.9942 0.5628 56.28 0.08 0.8625 ProteomeLM contextual percentile 0.54; strong pocket/AF2Bind evidence /main_page_ml/ML1177 2026-05-30T13:09:52Z 1106 ML0324 Q9CCW4 ML0324 Uncharacterized tRNA/rRNA methyltransferase ML0324 (EC 2.1.1.-) 309 59.665 Moderate candidate 0.2638 ProteomeLM contextual shift 0.07478694 1.0 64 1.0 579 6 0.7352 0.8232 82.32 0.36 1.0 2.1.1.- transferase ProteomeLM contextual percentile 0.26; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model; matched: transferase /main_page_ml/ML0324 2026-05-30T13:09:52Z 1107 ML2118 Q50130 echA6 ML2118 u650af Probable enoyl-CoA hydratase echA6 (EC 4.2.1.17) 247 59.665 Moderate candidate 0.2274 ProteomeLM contextual shift 0.06984759 1.0 66 1.0 815 148 0.9828 0.9505 95.05 0.36 1.0 4.2.1.17 isomerase ProteomeLM contextual percentile 0.23; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model; matched: isomerase /main_page_ml/ML2118 2026-05-30T13:09:52Z 1108 ML1412 Q9CC10 argG ML1412 Argininosuccinate synthase (EC 6.3.4.5) (Citrulline--aspartate ligase) 399 59.659 Moderate candidate 0.0695 ProteomeLM contextual shift 0.039809473 1.0 216 1.0 1255 116 0.9767 0.9425 94.25 0.64 1.0 6.3.4.5 PATHWAY: Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 2/3. {ECO:0000255|HAMAP-Rule:MF_00005}. ligase, synthase ProteomeLM contextual percentile 0.07; strong pocket/AF2Bind evidence; essential-process annotation; high-confidence Boltz2 model; matched: ligase, synthase /main_page_ml/ML1412 2026-05-30T13:09:52Z 1109 ML0430 Q9CCU4 ML0430 Membrane protein 454 59.644 Moderate candidate 0.4612 ProteomeLM contextual shift 0.09911838 1.0 93 1.0 1404 84 0.9467 0.8278 82.78 0.08 0.8625 ProteomeLM contextual percentile 0.46; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML0430 2026-05-30T13:09:52Z 1110 ML2211 Q50023 purL ML2211 MLCB5.30 Phosphoribosylformylglycinamidine synthase subunit PurL (FGAM synthase) (EC 6.3.5.3) (Formylglycinamide ribonucleotide amidotransferase subunit II) (FGAR amidotransferase II) (FGAR-AT II) (Glutamine amidotransferase PurL) (Phosphoribosylformylglycinamidine synthase subunit II) 754 59.615 Moderate candidate 0.0934 ProteomeLM contextual shift 0.046486057 1.0 76 1.0 2297 70 0.8521 0.9297 92.97 0.64 0.925 6.3.5.3 PATHWAY: Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 1/2. {ECO:0000255|HAMAP-Rule:MF_00420}. transferase, synthase ProteomeLM contextual percentile 0.09; strong pocket/AF2Bind evidence; essential-process annotation; high-confidence Boltz2 model; matched: transferase, synthase /main_page_ml/ML2211 2026-05-30T13:09:52Z 1111 ML0596 Q49690 csd2 ML0596 B1496_C2_193 MLCL536.25c Probable cysteine desulfurase 2 (EC 2.8.1.7) 418 59.612 Moderate candidate 0.1579 ProteomeLM contextual shift 0.06127371 1.0 93 1.0 1279 10 0.7621 0.9486 94.86 0.48 1.0 2.8.1.7 transferase, cofactor ProteomeLM contextual percentile 0.16; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model; matched: transferase, cofactor /main_page_ml/ML0596 2026-05-30T13:09:52Z 1112 ML0176 Q9CD67 ML0176 Possible secreted serine protease 382 59.611 Moderate candidate 0.4449 ProteomeLM contextual shift 0.09724885 1.0 56 1.0 1193 14 0.6902 0.7441 74.41 0.08 1.0 protease ProteomeLM contextual percentile 0.44; strong pocket/AF2Bind evidence; matched: protease /main_page_ml/ML0176 2026-05-30T13:09:52Z 1113 ML0587 Q7AQI1 ML0587 Membrane protein 311 59.524 Moderate candidate 0.3008 ProteomeLM contextual shift 0.07917272 1.0 46 1.0 649 54 0.8979 0.9198 91.98 0.24 1.0 PATHWAY: Porphyrin-containing compound metabolism. {ECO:0000256|ARBA:ARBA00023444}. oxidoreductase, reductase ProteomeLM contextual percentile 0.30; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: oxidoreductase, reductase /main_page_ml/ML0587 2026-05-30T13:09:52Z 1114 ML1299 Q7AQ75 ML1299 DUF3090 domain-containing protein 196 59.468 Moderate candidate 0.51 ProteomeLM contextual shift 0.10384176 1.0 24 1.0 633 10 0.7391 0.7992 79.92 0.0 0.8625 ProteomeLM contextual percentile 0.51; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML1299 2026-05-30T13:09:52Z 1115 ML2566 Q9CD22 ML2566 MaoC-like domain-containing protein 300 59.467 Moderate candidate 0.4029 ProteomeLM contextual shift 0.09286461 1.0 80 1.0 993 186 0.9939 0.8767 87.67 0.08 1.0 isomerase, synthase ProteomeLM contextual percentile 0.40; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: isomerase, synthase /main_page_ml/ML2566 2026-05-30T13:09:52Z 1116 ML1288 Q9CC46 ML1288 Possible peptidase 467 59.465 Moderate candidate 0.3916 ProteomeLM contextual shift 0.09172817 1.0 54 1.0 982 96 0.9937 0.9159 91.59 0.08 1.0 hydrolase, cofactor ProteomeLM contextual percentile 0.39; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: hydrolase, cofactor /main_page_ml/ML1288 2026-05-30T13:09:52Z 1117 ML1946 Q9CBH9 glpX ML1946 Fructose-1,6-bisphosphatase class 2 (FBPase class 2) (EC 3.1.3.11) (D-fructose-1,6-bisphosphate 1-phosphohydrolase class 2) 355 59.465 Moderate candidate 0.0758 ProteomeLM contextual shift 0.04205485 1.0 60 1.0 1022 76 0.9711 0.9012 90.12 0.64 1.0 3.1.3.11 PATHWAY: Carbohydrate biosynthesis; gluconeogenesis. hydrolase, cofactor ProteomeLM contextual percentile 0.08; strong pocket/AF2Bind evidence; essential-process annotation; high-confidence Boltz2 model; matched: hydrolase, cofactor /main_page_ml/ML1946 2026-05-30T13:09:52Z 1118 ML0501 P36429 aspS ML0501 MLCB1259.19 Aspartate--tRNA(Asp/Asn) ligase (EC 6.1.1.23) (Aspartyl-tRNA synthetase) (AspRS) (Non-discriminating aspartyl-tRNA synthetase) (ND-AspRS) 589 59.431 Moderate candidate 0.1084 ProteomeLM contextual shift 0.049887188 1.0 136 1.0 1181 6 0.666 0.9237 92.37 0.57 1.0 6.1.1.23 aminoacyl-trna, trna ligase, ligase, synthetase ProteomeLM contextual percentile 0.11; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model; matched: aminoacyl-trna, trna ligase, ligase, synthetase /main_page_ml/ML0501 2026-05-30T13:09:52Z 1119 ML1658 O69470 mutM fpg ML1658 MLCB1243.16 Formamidopyrimidine-DNA glycosylase (Fapy-DNA glycosylase) (EC 3.2.2.23) (DNA-(apurinic or apyrimidinic site) lyase MutM) (AP lyase MutM) (EC 4.2.99.18) 282 59.353 Moderate candidate 0.1585 ProteomeLM contextual shift 0.061375502 1.0 55 1.0 886 80 0.9689 0.9205 92.05 0.48 1.0 3.2.2.23; 4.2.99.18 lyase, cofactor ProteomeLM contextual percentile 0.16; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model; matched: lyase, cofactor /main_page_ml/ML1658 2026-05-30T13:09:52Z 1120 ML0698 Q7AQF8 sdhD ML0698 Succinate dehydrogenase hydrophobic membrane anchor protei 163 59.3 Moderate candidate 0.4674 ProteomeLM contextual shift 0.099720605 1.0 28 1.0 504 30 0.868 0.634 63.4 0.08 1.0 dehydrogenase ProteomeLM contextual percentile 0.47; strong pocket/AF2Bind evidence; matched: dehydrogenase /main_page_ml/ML0698 2026-05-30T13:09:52Z 1121 ML1079 Q9CCA4 tatB ML1079 Sec-independent protein translocase protein TatB 120 59.298 Moderate candidate 0.5639 ProteomeLM contextual shift 0.11099418 1.0 20 1.0 259 38 0.7924 0.4336 43.36 0.08 0.8625 ProteomeLM contextual percentile 0.56; strong pocket/AF2Bind evidence /main_page_ml/ML1079 2026-05-30T13:09:52Z 1122 ML1939 Q7AQ17 ML1939 Lipid droplet-associated protein 205 59.249 Moderate candidate 0.5977 ProteomeLM contextual shift 0.11688687 1.0 12 1.0 625 20 0.853 0.4703 47.03 0.0 0.8625 ProteomeLM contextual percentile 0.60; strong pocket/AF2Bind evidence /main_page_ml/ML1939 2026-05-30T13:09:52Z 1123 ML2227 O08361 purC ML2227 MLCB5.16 Phosphoribosylaminoimidazole-succinocarboxamide synthase (EC 6.3.2.6) (SAICAR synthetase) 297 59.242 Moderate candidate 0.1272 ProteomeLM contextual shift 0.054577395 1.0 40 1.0 623 58 0.9094 0.939 93.9 0.52 1.0 6.3.2.6 PATHWAY: Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate: step 1/2. synthetase, synthase ProteomeLM contextual percentile 0.13; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model; matched: synthetase, synthase /main_page_ml/ML2227 2026-05-30T13:09:52Z 1124 ML0771 Q9CCJ4 ahcY sahH ML0771 Adenosylhomocysteinase (EC 3.13.2.1) (S-adenosyl-L-homocysteine hydrolase) (AdoHcyase) 492 59.228 Moderate candidate 0.0332 ProteomeLM contextual shift 0.0241772 1.0 235 1.0 1512 72 0.9135 0.9366 93.66 0.685 1.0 3.13.2.1 PATHWAY: Amino-acid biosynthesis; L-homocysteine biosynthesis; L-homocysteine from S-adenosyl-L-homocysteine: step 1/1. {ECO:0000255|HAMAP-Rule:MF_00563}. nad, hydrolase, cofactor ProteomeLM contextual percentile 0.03; strong pocket/AF2Bind evidence; essential-process annotation; high-confidence Boltz2 model; matched: nad, hydrolase, cofactor /main_page_ml/ML0771 2026-05-30T13:09:52Z 1125 ML0994 Q7AQB7 ML0994 Uncharacterized protein 232 59.217 Moderate candidate 0.4605 ProteomeLM contextual shift 0.09903082 1.0 28 1.0 489 50 0.9828 0.9473 94.73 0.0 0.8625 ProteomeLM contextual percentile 0.46; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML0994 2026-05-30T13:09:52Z 1126 ML1810 Q9CBL7 moxR ML1810 MoxR homolog 377 59.215 Moderate candidate 0.453 ProteomeLM contextual shift 0.097925454 1.0 48 1.0 776 4 0.6894 0.8135 81.35 0.08 0.8625 ProteomeLM contextual percentile 0.45; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML1810 2026-05-30T13:09:52Z 1127 ML0535 Q9CCR3 carA ML0535 Carbamoyl phosphate synthase small chain (EC 6.3.5.5) (Carbamoyl phosphate synthetase glutamine chain) 375 59.194 Moderate candidate 0.0558 ProteomeLM contextual shift 0.035617586 1.0 84 1.0 757 14 0.6791 0.9443 94.43 0.64 1.0 6.3.5.5 PATHWAY: Amino-acid biosynthesis; L-arginine biosynthesis; carbamoyl phosphate from bicarbonate: step 1/1. {ECO:0000255|HAMAP-Rule:MF_01209}.; PATHWAY: Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 1/3. {ECO:0000255|HAMAP-Rule:MF_01209}. synthetase, synthase ProteomeLM contextual percentile 0.06; strong pocket/AF2Bind evidence; essential-process annotation; high-confidence Boltz2 model; matched: synthetase, synthase /main_page_ml/ML0535 2026-05-30T13:09:52Z 1128 ML1537 Q9CBV4 ML1537 Possible secreted protein 401 59.167 Moderate candidate 0.4643 ProteomeLM contextual shift 0.09942385 1.0 82 1.0 842 0 0.4666 0.7692 76.92 0.08 0.8625 ProteomeLM contextual percentile 0.46; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML1537 2026-05-30T13:09:52Z 1129 ML1030 Q7AQA6 ML1030 AB hydrolase-1 domain-containing protein 232 59.15 Moderate candidate 0.4154 ProteomeLM contextual shift 0.09380042 1.0 18 1.0 514 100 0.9953 0.9611 96.11 0.0 1.0 hydrolase ProteomeLM contextual percentile 0.42; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: hydrolase /main_page_ml/ML1030 2026-05-30T13:09:52Z 1130 ML0134 Q9CD82 fadD22 ML0134 Acyl-CoA synthetase 707 59.141 Moderate candidate 0.4135 ProteomeLM contextual shift 0.09366422 1.0 78 1.0 2172 102 0.8989 0.8067 80.67 0.08 1.0 ligase, synthetase ProteomeLM contextual percentile 0.41; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: ligase, synthetase /main_page_ml/ML0134 2026-05-30T13:09:52Z 1131 ML1705 O33102 ligA lig ML1705 MLCB637.10 DNA ligase (EC 6.5.1.2) (Polydeoxyribonucleotide synthase [NAD(+)]) 694 59.132 Moderate candidate 0.1065 ProteomeLM contextual shift 0.04944431 1.0 89 1.0 1393 10 0.7391 0.8104 81.04 0.615 1.0 6.5.1.2 dna replication, replication, nad, ligase, synthase, cofactor ProteomeLM contextual percentile 0.11; strong pocket/AF2Bind evidence; essential-process annotation; high-confidence Boltz2 model; matched: dna replication, replication, nad, ligase, synthase /main_page_ml/ML1705 2026-05-30T13:09:52Z 1132 ML2185 Q7APY0 desA1 ML2185 Acyl-[ACP] desaturase 338 59.112 Moderate candidate 0.3239 ProteomeLM contextual shift 0.081487894 1.0 64 1.0 1096 164 0.9824 0.8774 87.74 0.2 1.0 cofactor ProteomeLM contextual percentile 0.32; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: cofactor /main_page_ml/ML2185 2026-05-30T13:09:52Z 1133 ML1464 Q9CBZ5 proB ML1464 Glutamate 5-kinase (EC 2.7.2.11) (Gamma-glutamyl kinase) (GK) 367 59.112 Moderate candidate 0.0802 ProteomeLM contextual shift 0.042665605 1.0 63 1.0 1131 60 0.8952 0.8505 85.05 0.64 1.0 2.7.2.11 PATHWAY: Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-glutamate: step 1/2. {ECO:0000255|HAMAP-Rule:MF_00456}. kinase ProteomeLM contextual percentile 0.08; strong pocket/AF2Bind evidence; essential-process annotation; high-confidence Boltz2 model; matched: kinase /main_page_ml/ML1464 2026-05-30T13:09:52Z 1134 ML0584 Q9CCN4 ctaB ML0584 Protoheme IX farnesyltransferase (EC 2.5.1.141) (Heme B farnesyltransferase) (Heme O synthase) 308 59.084 Moderate candidate 0.1397 ProteomeLM contextual shift 0.05745164 1.0 28 1.0 1023 120 0.9776 0.8794 87.94 0.52 1.0 2.5.1.141 PATHWAY: Porphyrin-containing compound metabolism; heme O biosynthesis; heme O from protoheme: step 1/1. {ECO:0000255|HAMAP-Rule:MF_00154}. transferase, synthase ProteomeLM contextual percentile 0.14; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model; matched: transferase, synthase /main_page_ml/ML0584 2026-05-30T13:09:52Z 1135 ML2041 P52678 oxyR ML2041 Probable hydrogen peroxide-inducible genes activator 311 59.074 Moderate candidate 0.4129 ProteomeLM contextual shift 0.09349641 1.0 101 1.0 941 16 0.7433 0.8497 84.97 0.125 0.8625 transcription ProteomeLM contextual percentile 0.41; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: transcription /main_page_ml/ML2041 2026-05-30T13:09:52Z 1136 ML0198 Q7AQM5 cspA ML0198 Probable cold shock protein A 67 59.045 Moderate candidate 0.4511 ProteomeLM contextual shift 0.09767236 1.0 8 1.0 218 34 0.72 0.9081 90.81 0.08 0.7575 ProteomeLM contextual percentile 0.45; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML0198 2026-05-30T13:09:52Z 1137 ML2066 O32912 guaB1 ML2066 MLCB1788.20 GMP reductase (EC 1.7.1.7) (Guanosine 5'-monophosphate reductase) (GMPR) 478 59.043 Moderate candidate 0.0388 ProteomeLM contextual shift 0.028422406 1.0 325 1.0 1442 16 0.6469 0.8983 89.83 0.685 1.0 1.7.1.7 PATHWAY: Purine metabolism; IMP biosynthesis via salvage pathway. {ECO:0000255|HAMAP-Rule:MF_02250}. nad, dehydrogenase, reductase, cofactor ProteomeLM contextual percentile 0.04; strong pocket/AF2Bind evidence; essential-process annotation; high-confidence Boltz2 model; matched: nad, dehydrogenase, reductase, cofactor /main_page_ml/ML2066 2026-05-30T13:09:52Z 1138 ML1856 O32988 rplP ML1856 MLCB2492.09 Large ribosomal subunit protein uL16 (50S ribosomal protein L16) 138 59.005 Moderate candidate 0.3759 ProteomeLM contextual shift 0.08959802 1.0 10 1.0 443 58 0.9399 0.7922 79.22 0.215 0.8625 translation, ribosome, ribosomal ProteomeLM contextual percentile 0.38; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: translation, ribosome, ribosomal /main_page_ml/ML1856 2026-05-30T13:09:52Z 1139 ML0782 Q9CCI5 ML0782 Transmembrane transport protein 385 58.988 Moderate candidate 0.4392 ProteomeLM contextual shift 0.09660419 1.0 76 1.0 784 28 0.9683 0.839 83.9 0.08 0.8625 ProteomeLM contextual percentile 0.44; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML0782 2026-05-30T13:09:52Z 1140 ML1478 Q9CBY5 ML1478 S-methylmethionine:homocysteine methyltransferase 293 58.981 Moderate candidate 0.3033 ProteomeLM contextual shift 0.07936733 1.0 34 1.0 940 122 0.998 0.9366 93.66 0.2 1.0 transferase, cofactor ProteomeLM contextual percentile 0.30; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: transferase, cofactor /main_page_ml/ML1478 2026-05-30T13:09:52Z 1141 ML1192 Q9X7E3 acpS ML1192 MLCB458.07 Holo-[acyl-carrier-protein] synthase (Holo-ACP synthase) (EC 2.7.8.7) (4'-phosphopantetheinyl transferase AcpS) 130 58.957 Moderate candidate 0.1654 ProteomeLM contextual shift 0.062409427 1.0 78 1.0 404 28 0.7664 0.8567 85.67 0.48 1.0 2.7.8.7 transferase, synthase, cofactor ProteomeLM contextual percentile 0.17; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model; matched: transferase, synthase, cofactor /main_page_ml/ML1192 2026-05-30T13:09:52Z 1142 ML0876 Q9CCF0 ctaF ML0876 Probable cytochrome c oxidase polypeptide 4 (EC 7.1.1.9) (Cytochrome aa3 subunit 4) (Cytochrome c oxidase polypeptide IV) 139 58.947 Moderate candidate 0.2982 ProteomeLM contextual shift 0.079042725 1.0 20 1.0 297 38 0.8094 0.6308 63.08 0.36 1.0 7.1.1.9 ProteomeLM contextual percentile 0.30; strong pocket/AF2Bind evidence; functional annotation support /main_page_ml/ML0876 2026-05-30T13:09:52Z 1143 ML0269 Q7AQK8 fgd ML0269 F420-dependent glucose-6-phosphate dehydrogenase (FGD) (G6PD) (EC 1.1.98.2) 336 58.921 Moderate candidate 0.136 ProteomeLM contextual shift 0.057016652 1.0 88 1.0 716 88 0.9829 0.9562 95.62 0.48 1.0 1.1.98.2 enzyme, oxidoreductase, dehydrogenase ProteomeLM contextual percentile 0.14; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model; matched: enzyme, oxidoreductase, dehydrogenase /main_page_ml/ML0269 2026-05-30T13:09:52Z 1144 ML1131 P45836 thrB ML1131 Homoserine kinase (HK) (HSK) (EC 2.7.1.39) 315 58.901 Moderate candidate 0.0495 ProteomeLM contextual shift 0.032963883 1.0 52 1.0 977 64 0.8714 0.9369 93.69 0.64 1.0 2.7.1.39 PATHWAY: Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 4/5. {ECO:0000255|HAMAP-Rule:MF_00384}. kinase ProteomeLM contextual percentile 0.05; strong pocket/AF2Bind evidence; essential-process annotation; high-confidence Boltz2 model; matched: kinase /main_page_ml/ML1131 2026-05-30T13:09:52Z 1145 ML1906 Q9CBK0 nusG ML1906 Transcription termination/antitermination protein NusG 228 58.874 Moderate candidate 0.4486 ProteomeLM contextual shift 0.09740513 1.0 12 1.0 698 28 0.8686 0.7048 70.48 0.125 0.8625 transcription ProteomeLM contextual percentile 0.45; strong pocket/AF2Bind evidence; matched: transcription /main_page_ml/ML1906 2026-05-30T13:09:52Z 1146 ML2490 Q9CB26 clpB ML2490 Chaperone protein ClpB 848 58.871 Moderate candidate 0.4054 ProteomeLM contextual shift 0.09300566 1.0 70 1.0 2604 0 0.3514 0.7807 78.07 0.2 0.7875 ProteomeLM contextual percentile 0.41; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML2490 2026-05-30T13:09:52Z 1147 ML0207 Q7AQL8 ML0207 Glycosyltransferase 239 58.865 Moderate candidate 0.4505 ProteomeLM contextual shift 0.09758061 1.0 31 1.0 784 134 0.9839 0.8097 80.97 0.0 1.0 transferase ProteomeLM contextual percentile 0.45; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: transferase /main_page_ml/ML0207 2026-05-30T13:09:52Z 1148 ML1329 P54076 pafB ML1329 B2126_C3_266 MLCB2533.25 Protein PafB 331 58.841 Moderate candidate 0.5345 ProteomeLM contextual shift 0.107272565 1.0 44 1.0 1042 98 0.8974 0.651 65.1 0.0 0.8625 ProteomeLM contextual percentile 0.53; strong pocket/AF2Bind evidence /main_page_ml/ML1329 2026-05-30T13:09:52Z 1149 ML1248 Q7AQ80 ettA ML1248 Energy-dependent translational throttle protein EttA (EC 3.6.1.-) (Translational regulatory factor EttA) 556 58.823 Moderate candidate 0.0984 ProteomeLM contextual shift 0.047387414 1.0 251 1.0 1675 14 0.7873 0.898 89.8 0.57 1.0 3.6.1.- translation, ribosome ProteomeLM contextual percentile 0.10; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model; matched: translation, ribosome /main_page_ml/ML1248 2026-05-30T13:09:52Z 1150 ML1889 P30770 nfo end ML1889 Probable endonuclease 4 (EC 3.1.21.2) (Endodeoxyribonuclease IV) (Endonuclease IV) 252 58.751 Moderate candidate 0.1291 ProteomeLM contextual shift 0.05516673 1.0 24 1.0 788 64 0.951 0.9634 96.34 0.48 1.0 3.1.21.2 hydrolase, cofactor ProteomeLM contextual percentile 0.13; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model; matched: hydrolase, cofactor /main_page_ml/ML1889 2026-05-30T13:09:52Z 1151 ML1573 Q9CBU9 ML1573 Possible amidotransferase 249 58.732 Moderate candidate 0.3634 ProteomeLM contextual shift 0.087847516 1.0 112 1.0 771 48 0.8534 0.9413 94.13 0.08 1.0 transferase, hydrolase ProteomeLM contextual percentile 0.36; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: transferase, hydrolase /main_page_ml/ML1573 2026-05-30T13:09:52Z 1152 ML0333 Q9CCW2 pxpA ML0333 5-oxoprolinase subunit A (5-OPase subunit A) (EC 3.5.2.9) (5-oxoprolinase (ATP-hydrolyzing) subunit A) 252 58.712 Moderate candidate 0.2011 ProteomeLM contextual shift 0.06646147 1.0 58 1.0 826 140 0.9936 0.9472 94.72 0.36 1.0 3.5.2.9 ProteomeLM contextual percentile 0.20; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model /main_page_ml/ML0333 2026-05-30T13:09:52Z 1153 ML0752 Q9CCK7 wbbL ML0752 N-acetylglucosaminyl-diphospho-decaprenol L-rhamnosyltransferase (EC 2.4.1.289) (Rhamnosyltransferase WbbL) (dTDP-Rha:alpha-D-GlcNAc-pyrophosphate polyprenol, alpha-3-L-rhamnosyltransferase) 308 58.677 Moderate candidate 0.2331 ProteomeLM contextual shift 0.0702493 1.0 32 1.0 1005 162 0.9704 0.8319 83.19 0.36 1.0 2.4.1.289 transferase, cofactor ProteomeLM contextual percentile 0.23; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model; matched: transferase, cofactor /main_page_ml/ML0752 2026-05-30T13:09:52Z 1154 ML2076 Q7APZ3 ML2076 FHA domain-containing protein 162 58.674 Moderate candidate 0.5132 ProteomeLM contextual shift 0.104291864 1.0 10 1.0 350 12 0.696 0.7089 70.89 0.0 0.8625 ProteomeLM contextual percentile 0.51; strong pocket/AF2Bind evidence /main_page_ml/ML2076 2026-05-30T13:09:52Z 1155 ML1094 Q9CC98 ML1094 Short chain alcohol dehydrogenase 277 58.674 Moderate candidate 0.3709 ProteomeLM contextual shift 0.088838585 1.0 38 1.0 920 178 0.9911 0.9091 90.91 0.08 1.0 oxidoreductase, dehydrogenase, reductase ProteomeLM contextual percentile 0.37; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: oxidoreductase, dehydrogenase, reductase /main_page_ml/ML1094 2026-05-30T13:09:52Z 1156 ML2603 Q9CD03 ML2603 Monoacylglycerol lipase (EC 3.1.1.23) 279 58.644 Moderate candidate 0.1767 ProteomeLM contextual shift 0.063383676 1.0 54 1.0 918 162 0.9956 0.936 93.6 0.405 1.0 3.1.1.23 cell wall, hydrolase ProteomeLM contextual percentile 0.18; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model; matched: cell wall, hydrolase /main_page_ml/ML2603 2026-05-30T13:09:52Z 1157 ML1340 Q7AQ62 ML1340 Possible reductase 268 58.63 Moderate candidate 0.2619 ProteomeLM contextual shift 0.074635446 1.0 40 1.0 874 140 0.9476 0.8764 87.64 0.285 1.0 PATHWAY: Cofactor biosynthesis; riboflavin biosynthesis. {ECO:0000256|ARBA:ARBA00005104}. cofactor biosynthesis, reductase, cofactor ProteomeLM contextual percentile 0.26; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: cofactor biosynthesis, reductase, cofactor /main_page_ml/ML1340 2026-05-30T13:09:52Z 1158 ML2391 Q7APV3 mca ML2391 Mycothiol S-conjugate amidase (EC 3.5.1.115) 290 58.63 Moderate candidate 0.1341 ProteomeLM contextual shift 0.056781817 1.0 50 1.0 949 158 0.9989 0.9337 93.37 0.48 1.0 3.5.1.115 hydrolase, cofactor ProteomeLM contextual percentile 0.13; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model; matched: hydrolase, cofactor /main_page_ml/ML2391 2026-05-30T13:09:52Z 1159 ML1958 Q9X799 rpsD ML1958 MLCB1222.28c Small ribosomal subunit protein uS4 (30S ribosomal protein S4) 201 58.617 Moderate candidate 0.3446 ProteomeLM contextual shift 0.08524265 1.0 18 1.0 411 18 0.9293 0.8631 86.31 0.215 0.8625 translation, ribosome, ribosomal ProteomeLM contextual percentile 0.34; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: translation, ribosome, ribosomal /main_page_ml/ML1958 2026-05-30T13:09:52Z 1160 ML1992 Q9CBG4 ML1992 Oxidoreductase 289 58.586 Moderate candidate 0.3678 ProteomeLM contextual shift 0.08851667 1.0 42 1.0 931 128 0.9614 0.9113 91.13 0.08 1.0 oxidoreductase, reductase, cofactor ProteomeLM contextual percentile 0.37; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: oxidoreductase, reductase, cofactor /main_page_ml/ML1992 2026-05-30T13:09:52Z 1161 ML1155 P53524 nucS ML1155 B1549_C3_223 Endonuclease NucS (EC 3.1.-.-) 220 58.551 Moderate candidate 0.3045 ProteomeLM contextual shift 0.07943495 1.0 54 1.0 698 76 0.9541 0.8093 80.93 0.24 1.0 3.1.-.- ProteomeLM contextual percentile 0.30; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML1155 2026-05-30T13:09:52Z 1162 ML2670 Q9CCY5 ML2670 Conserved integral membrane protein 666 58.536 Moderate candidate 0.3822 ProteomeLM contextual shift 0.090343624 1.0 156 1.0 2005 14 0.6229 0.8559 85.59 0.08 1.0 transferase ProteomeLM contextual percentile 0.38; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: transferase /main_page_ml/ML2670 2026-05-30T13:09:52Z 1163 ML2094 Q50098 pstC phoW1 pstC2 ML2094 Phosphate transport system permease protein PstC 319 58.535 Moderate candidate 0.4242 ProteomeLM contextual shift 0.09497963 1.0 50 1.0 966 18 0.7383 0.8464 84.64 0.08 0.8625 ProteomeLM contextual percentile 0.42; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML2094 2026-05-30T13:09:52Z 1164 ML1117 Q9CC85 ML1117 Uncharacterized protein ML1117 (EC 3.1.3.-) 161 58.524 Moderate candidate 0.2694 ProteomeLM contextual shift 0.07567015 1.0 24 1.0 521 76 0.9538 0.9294 92.94 0.24 1.0 3.1.3.- hydrolase ProteomeLM contextual percentile 0.27; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: hydrolase /main_page_ml/ML1117 2026-05-30T13:09:52Z 1165 ML1694 O33114 ilvC ML1694 MLCB637.22 Ketol-acid reductoisomerase (NADP(+)) (KARI) (EC 1.1.1.86) (Acetohydroxy-acid isomeroreductase) (AHIR) (Alpha-keto-beta-hydroxylacyl reductoisomerase) (Ketol-acid reductoisomerase type 1) (Ketol-acid reductoisomerase type I) 333 58.512 Moderate candidate 0.0175 ProteomeLM contextual shift 0.017709343 1.0 74 1.0 1107 216 0.9734 0.9198 91.98 0.685 1.0 1.1.1.86 PATHWAY: Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 2/4. {ECO:0000255|HAMAP-Rule:MF_00435}.; PATHWAY: Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 2/4. {ECO:0000255|HAMAP-Rule:MF_00435}. nad, isomerase, reductase, cofactor ProteomeLM contextual percentile 0.02; strong pocket/AF2Bind evidence; essential-process annotation; high-confidence Boltz2 model; matched: nad, isomerase, reductase, cofactor /main_page_ml/ML1694 2026-05-30T13:09:52Z 1166 ML1525 Q9CBV8 ML1525 Flavodoxin 151 58.478 Moderate candidate 0.4348 ProteomeLM contextual shift 0.095922485 1.0 48 1.0 342 0 0.4888 0.9634 96.34 0.0 0.8625 ProteomeLM contextual percentile 0.43; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML1525 2026-05-30T13:09:52Z 1167 ML1623 O33012 htpG ML1623 MLCB250.19c Chaperone protein HtpG (Heat shock protein HtpG) (High temperature protein G) 656 58.473 Moderate candidate 0.4317 ProteomeLM contextual shift 0.095540605 1.0 164 1.0 1984 32 0.7521 0.8139 81.39 0.08 0.8625 ProteomeLM contextual percentile 0.43; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML1623 2026-05-30T13:09:52Z 1168 ML2235 Q50144 purD ML2235 MLCB5.08 Phosphoribosylamine--glycine ligase (EC 6.3.4.13) (GARS) (Glycinamide ribonucleotide synthetase) (Phosphoribosylglycinamide synthetase) 422 58.468 Moderate candidate 0.0382 ProteomeLM contextual shift 0.02838174 1.0 58 1.0 1301 70 0.8723 0.933 93.3 0.64 1.0 6.3.4.13 PATHWAY: Purine metabolism; IMP biosynthesis via de novo pathway; N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate: step 2/2. {ECO:0000255|HAMAP-Rule:MF_00138}. ligase, synthetase, cofactor ProteomeLM contextual percentile 0.04; strong pocket/AF2Bind evidence; essential-process annotation; high-confidence Boltz2 model; matched: ligase, synthetase, cofactor /main_page_ml/ML2235 2026-05-30T13:09:52Z 1169 ML0257 Q9CD40 ML0257 Septum formation initiator subfamily protein 167 58.46 Moderate candidate 0.4405 ProteomeLM contextual shift 0.09674008 1.0 26 1.0 523 44 0.8451 0.9418 94.18 0.0 0.8625 ProteomeLM contextual percentile 0.44; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML0257 2026-05-30T13:09:52Z 1170 ML2440 P54883 senX3 ML2440 B2168_C3_247 Sensor-like histidine kinase SenX3 (EC 2.7.13.3) 443 58.456 Moderate candidate 0.2556 ProteomeLM contextual shift 0.07367487 1.0 38 1.0 1370 14 0.6206 0.7308 73.08 0.36 1.0 2.7.13.3 kinase ProteomeLM contextual percentile 0.26; strong pocket/AF2Bind evidence; functional annotation support; matched: kinase /main_page_ml/ML2440 2026-05-30T13:09:52Z 1171 ML1740 Q9CBP7 ML1740 Possible short chain reductase 312 58.453 Moderate candidate 0.3872 ProteomeLM contextual shift 0.09093558 1.0 98 1.0 1043 214 0.9952 0.83 83.0 0.08 1.0 oxidoreductase, dehydrogenase, reductase ProteomeLM contextual percentile 0.39; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: oxidoreductase, dehydrogenase, reductase /main_page_ml/ML1740 2026-05-30T13:09:52Z 1172 ML0119 Q9CD95 lipE ML0119 Probable hydrolase 411 58.433 Moderate candidate 0.3571 ProteomeLM contextual shift 0.087015316 1.0 68 1.0 1344 222 0.9804 0.9333 93.33 0.08 1.0 hydrolase ProteomeLM contextual percentile 0.36; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: hydrolase /main_page_ml/ML0119 2026-05-30T13:09:52Z 1173 ML0450 O07145 pdxS ML0450 MLCL581.12c Pyridoxal 5'-phosphate synthase subunit PdxS (PLP synthase subunit PdxS) (EC 4.3.3.6) (Pdx1) 307 58.413 Moderate candidate 0.0182 ProteomeLM contextual shift 0.017721912 1.0 244 1.0 949 56 0.8403 0.9077 90.77 0.685 1.0 4.3.3.6 PATHWAY: Cofactor biosynthesis; pyridoxal 5'-phosphate biosynthesis. {ECO:0000255|HAMAP-Rule:MF_01824}. cofactor biosynthesis, synthase, cofactor ProteomeLM contextual percentile 0.02; strong pocket/AF2Bind evidence; essential-process annotation; high-confidence Boltz2 model; matched: cofactor biosynthesis, synthase, cofactor /main_page_ml/ML0450 2026-05-30T13:09:52Z 1174 ML1712 O33095 etfB fixA ML1712 MLCB637.03 Electron transfer flavoprotein subunit beta (Beta-ETF) (Electron transfer flavoprotein small subunit) (ETFSS) 266 58.401 Moderate candidate 0.3841 ProteomeLM contextual shift 0.090593666 1.0 18 1.0 883 170 0.9981 0.8358 83.58 0.08 1.0 cofactor ProteomeLM contextual percentile 0.38; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: cofactor /main_page_ml/ML1712 2026-05-30T13:09:52Z 1175 ML1612 O33021 lepB ML1612 MLCB250.39 Probable signal peptidase I (SPase I) (EC 3.4.21.89) (Leader peptidase I) 289 58.389 Moderate candidate 0.141 ProteomeLM contextual shift 0.057748843 1.0 28 1.0 927 0 0.4647 0.7954 79.54 0.525 1.0 3.4.21.89 signal peptidase ProteomeLM contextual percentile 0.14; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model; matched: signal peptidase /main_page_ml/ML1612 2026-05-30T13:09:52Z 1176 ML1452 Q9CC00 ML1452 Possible phosphoglycerate mutase 224 58.376 Moderate candidate 0.3271 ProteomeLM contextual shift 0.08196685 1.0 50 1.0 701 58 0.9204 0.9304 93.04 0.2 0.8625 ProteomeLM contextual percentile 0.33; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML1452 2026-05-30T13:09:52Z 1177 ML1813 Q9CBL4 ML1813 Uncharacterized protein 190 58.363 Moderate candidate 0.4875 ProteomeLM contextual shift 0.101602346 1.0 12 1.0 630 0 0.3831 0.7677 76.77 0.0 0.8625 ProteomeLM contextual percentile 0.49; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML1813 2026-05-30T13:09:52Z 1178 ML2210 Q7APX5 ML2210 Calcineurin-like phosphoesterase domain-containing protein 317 58.337 Moderate candidate 0.3966 ProteomeLM contextual shift 0.09220591 1.0 76 1.0 1019 136 0.9364 0.9231 92.31 0.08 0.8625 ProteomeLM contextual percentile 0.40; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML2210 2026-05-30T13:09:52Z 1179 ML0211 Q7AQL6 ML0211 Carboxypeptidase 461 58.324 Moderate candidate 0.3904 ProteomeLM contextual shift 0.0915323 1.0 44 1.0 1390 14 0.6002 0.8537 85.37 0.125 0.8625 peptidoglycan ProteomeLM contextual percentile 0.39; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: peptidoglycan /main_page_ml/ML0211 2026-05-30T13:09:52Z 1180 ML2141 Q7APY5 ML2141 DUF2530 domain-containing protein 91 58.307 Moderate candidate 0.5201 ProteomeLM contextual shift 0.10481102 1.0 12 1.0 302 58 0.9759 0.7531 75.31 0.0 0.7575 ProteomeLM contextual percentile 0.52; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML2141 2026-05-30T13:09:52Z 1181 ML1320 Q7AQ69 ML1320 Proteasome accessory factor PafA2 514 58.291 Moderate candidate 0.1823 ProteomeLM contextual shift 0.063941464 1.0 221 1.0 1545 6 0.6074 0.881 88.1 0.405 1.0 PATHWAY: Protein degradation; proteasomal Pup-dependent pathway. {ECO:0000256|ARBA:ARBA00004707}. proteasome, ligase, hydrolase ProteomeLM contextual percentile 0.18; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model; matched: proteasome, ligase, hydrolase /main_page_ml/ML1320 2026-05-30T13:09:52Z 1182 ML1613 O33020 rplS ML1613 MLCB250.38 Large ribosomal subunit protein bL19 (50S ribosomal protein L19) 113 58.287 Moderate candidate 0.3835 ProteomeLM contextual shift 0.09057374 1.0 10 1.0 364 10 0.7204 0.7991 79.91 0.215 0.7575 translation, ribosome, ribosomal ProteomeLM contextual percentile 0.38; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: translation, ribosome, ribosomal /main_page_ml/ML1613 2026-05-30T13:09:52Z 1183 ML2639 Q9CCZ5 ML2639 Aldehyde dehydrogenase 501 58.28 Moderate candidate 0.2675 ProteomeLM contextual shift 0.075478055 1.0 128 1.0 1561 116 0.9194 0.9016 90.16 0.245 1.0 nad, dehydrogenase ProteomeLM contextual percentile 0.27; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: nad, dehydrogenase /main_page_ml/ML2639 2026-05-30T13:09:52Z 1184 ML1363 P53529 pyrG ML1363 MLC1351.09c CTP synthase (EC 6.3.4.2) (Cytidine 5'-triphosphate synthase) (Cytidine triphosphate synthetase) (CTP synthetase) (CTPS) (UTP--ammonia ligase) 590 58.271 Moderate candidate 0.0501 ProteomeLM contextual shift 0.03370662 1.0 248 1.0 1797 54 0.798 0.8716 87.16 0.64 1.0 6.3.4.2 PATHWAY: Pyrimidine metabolism; CTP biosynthesis via de novo pathway; CTP from UDP: step 2/2. {ECO:0000255|HAMAP-Rule:MF_01227}. ligase, synthetase, synthase ProteomeLM contextual percentile 0.05; strong pocket/AF2Bind evidence; essential-process annotation; high-confidence Boltz2 model; matched: ligase, synthetase, synthase /main_page_ml/ML1363 2026-05-30T13:09:52Z 1185 ML0174 Q9CD68 mprA ML0174 MLCB373.26 Response regulator MprA (Mycobacterial persistence regulator A) 228 58.24 Moderate candidate 0.4104 ProteomeLM contextual shift 0.09326732 1.0 32 1.0 709 10 0.7333 0.7751 77.51 0.125 0.8625 transcription ProteomeLM contextual percentile 0.41; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: transcription /main_page_ml/ML0174 2026-05-30T13:09:52Z 1186 ML2420 Q9CB60 hemD ML2420 Possible uroporphyrin-III C-methyltransferase 563 58.226 Moderate candidate 0.3853 ProteomeLM contextual shift 0.09068652 1.0 101 1.0 1136 20 0.8246 0.814 81.4 0.08 1.0 transferase, synthase ProteomeLM contextual percentile 0.39; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: transferase, synthase /main_page_ml/ML2420 2026-05-30T13:09:52Z 1187 ML1138 P53431 ML1138 u471d Uncharacterized protein ML1138 153 58.205 Moderate candidate 0.4518 ProteomeLM contextual shift 0.097738475 1.0 32 1.0 477 36 0.8605 0.7168 71.68 0.08 0.8625 ProteomeLM contextual percentile 0.45; strong pocket/AF2Bind evidence /main_page_ml/ML1138 2026-05-30T13:09:52Z 1188 ML0899 Q7AQD1 ML0899 Alpha-(1->6)-mannopyranosyltransferase A 505 58.188 Moderate candidate 0.359 ProteomeLM contextual shift 0.08719217 1.0 85 1.0 1575 0 0.4715 0.9022 90.22 0.08 1.0 transferase ProteomeLM contextual percentile 0.36; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: transferase /main_page_ml/ML0899 2026-05-30T13:09:52Z 1189 ML1025 Q7AQB0 ML1025 Possible secreted protein 216 58.135 Moderate candidate 0.4731 ProteomeLM contextual shift 0.100301154 1.0 18 1.0 672 8 0.6408 0.7953 79.53 0.0 0.8625 ProteomeLM contextual percentile 0.47; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML1025 2026-05-30T13:09:52Z 1190 ML0452 O07147 pimA ML0452 MLCL581.14c Phosphatidyl-myo-inositol mannosyltransferase (EC 2.4.1.345) (Alpha-mannosyltransferase) (GDP-mannose-dependent alpha-(1-2)-phosphatidylinositol mannosyltransferase) (Guanosine diphosphomannose-phosphatidyl-inositol alpha-mannosyltransferase) (Phosphatidylinositol alpha-mannosyltransferase) (PI alpha-mannosyltransferase) 374 58.09 Moderate candidate 0.0188 ProteomeLM contextual shift 0.017728336 1.0 54 1.0 1187 130 0.9716 0.8732 87.32 0.685 1.0 2.4.1.345 PATHWAY: Phospholipid metabolism; phosphatidylinositol metabolism. {ECO:0000250|UniProtKB:A0QWG6}. lipid metabolism, transferase, cofactor ProteomeLM contextual percentile 0.02; strong pocket/AF2Bind evidence; essential-process annotation; high-confidence Boltz2 model; matched: lipid metabolism, transferase, cofactor /main_page_ml/ML0452 2026-05-30T13:09:52Z 1191 ML1877 P30768 tuf ML1877 Elongation factor Tu (EF-Tu) (EC 3.6.5.3) 396 58.087 Moderate candidate 0.1153 ProteomeLM contextual shift 0.0515207 1.0 52 1.0 1223 30 0.8265 0.8552 85.52 0.525 1.0 3.6.5.3 translation ProteomeLM contextual percentile 0.12; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model; matched: translation /main_page_ml/ML1877 2026-05-30T13:09:52Z 1192 ML2589 Q9CD14 mce1A ML2589 Cell invasion protein 441 58.055 Moderate candidate 0.5382 ProteomeLM contextual shift 0.10754233 1.0 40 1.0 903 2 0.5322 0.3992 39.92 0.08 0.8625 ProteomeLM contextual percentile 0.54; strong pocket/AF2Bind evidence /main_page_ml/ML2589 2026-05-30T13:09:52Z 1193 ML0890 Q7AQD9 ML0890 Possible membrane transport ATPase 415 58.015 Moderate candidate 0.4173 ProteomeLM contextual shift 0.09415022 1.0 82 1.0 862 24 0.889 0.8185 81.85 0.08 0.8625 ProteomeLM contextual percentile 0.42; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML0890 2026-05-30T13:09:52Z 1194 ML0774 Q9CCJ1 mtrB ML0774 Sensor histidine kinase MtrB (EC 2.7.13.3) 562 58.013 Moderate candidate 0.26 ProteomeLM contextual shift 0.07438102 1.0 92 1.0 1714 16 0.9042 0.6712 67.12 0.36 1.0 2.7.13.3 kinase ProteomeLM contextual percentile 0.26; strong pocket/AF2Bind evidence; functional annotation support; matched: kinase /main_page_ml/ML0774 2026-05-30T13:09:52Z 1195 ML2591 Q9CD12 mce1C ML2591 Secreted protein 519 57.979 Moderate candidate 0.5081 ProteomeLM contextual shift 0.10371232 1.0 44 1.0 1592 30 0.9547 0.4969 49.69 0.08 0.8625 ProteomeLM contextual percentile 0.51; strong pocket/AF2Bind evidence /main_page_ml/ML2591 2026-05-30T13:09:52Z 1196 ML0270 Q7AQK7 ML0270 Metallo-beta-lactamase domain-containing protein 251 57.95 Moderate candidate 0.4273 ProteomeLM contextual shift 0.09514106 1.0 36 1.0 803 100 0.9795 0.9368 93.68 0.0 0.8625 ProteomeLM contextual percentile 0.43; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML0270 2026-05-30T13:09:52Z 1197 ML1512 Q9CBW5 rnj ML1512 Ribonuclease J (RNase J) (EC 3.1.-.-) 558 57.947 Moderate candidate 0.2049 ProteomeLM contextual shift 0.066866614 1.0 175 1.0 1760 172 0.9741 0.8576 85.76 0.36 1.0 3.1.-.- cofactor ProteomeLM contextual percentile 0.20; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model; matched: cofactor /main_page_ml/ML1512 2026-05-30T13:09:52Z 1198 ML1427 Q7AQ51 ML1427 Possible ABC-transport lipoprotein 445 57.934 Moderate candidate 0.4467 ProteomeLM contextual shift 0.09736822 1.0 59 1.0 921 62 0.9668 0.8673 86.73 0.0 0.8625 ProteomeLM contextual percentile 0.45; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML1427 2026-05-30T13:09:52Z 1199 ML1352 Q49900 tyrS ML1352 MLC1351.16c Tyrosine--tRNA ligase (EC 6.1.1.1) (Tyrosyl-tRNA synthetase) (TyrRS) 426 57.931 Moderate candidate 0.0789 ProteomeLM contextual shift 0.042532682 1.0 158 1.0 1294 32 0.724 0.8768 87.68 0.57 1.0 6.1.1.1 aminoacyl-trna, trna ligase, ligase, synthetase ProteomeLM contextual percentile 0.08; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model; matched: aminoacyl-trna, trna ligase, ligase, synthetase /main_page_ml/ML1352 2026-05-30T13:09:52Z 1200 ML2324 Q9CB76 leuA ML2324 MLCB2407.26c 2-isopropylmalate synthase (EC 2.3.3.13) (Alpha-IPM synthase) (Alpha-isopropylmalate synthase) 607 57.93 Moderate candidate 0.0326 ProteomeLM contextual shift 0.024023024 1.0 219 1.0 1862 2 0.5578 0.8989 89.89 0.64 1.0 2.3.3.13 PATHWAY: Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 1/4. {ECO:0000255|HAMAP-Rule:MF_00572}. transferase, synthase, cofactor ProteomeLM contextual percentile 0.03; strong pocket/AF2Bind evidence; essential-process annotation; high-confidence Boltz2 model; matched: transferase, synthase, cofactor /main_page_ml/ML2324 2026-05-30T13:09:52Z 1201 ML1864 P30765 rpsJ ML1864 Small ribosomal subunit protein uS10 (30S ribosomal protein S10) 101 57.92 Moderate candidate 0.3553 ProteomeLM contextual shift 0.086616516 1.0 10 1.0 344 2 0.5804 0.8611 86.11 0.215 0.7575 translation, ribosome, ribosomal ProteomeLM contextual percentile 0.36; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: translation, ribosome, ribosomal /main_page_ml/ML1864 2026-05-30T13:09:52Z 1202 ML1089 Q7AQ92 ML1089 Trehalose import ATP-binding protein SugC (Nucleotide-binding domain of SugABC transporter) (SugABC transporter ATPase SugC) 392 57.89 Moderate candidate 0.3346 ProteomeLM contextual shift 0.08344614 1.0 139 1.0 1192 32 0.8908 0.8554 85.54 0.2 0.8625 ProteomeLM contextual percentile 0.33; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML1089 2026-05-30T13:09:52Z 1203 ML2199 Q9CBC7 ML2199 DUF1416 domain-containing protein 100 57.856 Moderate candidate 0.4743 ProteomeLM contextual shift 0.10033822 1.0 8 1.0 320 40 0.9025 0.868 86.8 0.0 0.7575 ProteomeLM contextual percentile 0.47; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML2199 2026-05-30T13:09:52Z 1204 ML0002 P46387 dnaN ML0002 Beta sliding clamp (Beta clamp) (Sliding clamp) (Beta-clamp processivity factor) (DNA polymerase III beta sliding clamp subunit) (DNA polymerase III subunit beta) 399 57.833 Moderate candidate 0.3421 ProteomeLM contextual shift 0.08484438 1.0 34 1.0 1201 8 0.6203 0.8834 88.34 0.17 0.8625 dna replication, replication ProteomeLM contextual percentile 0.34; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: dna replication, replication /main_page_ml/ML0002 2026-05-30T13:09:52Z 1205 ML2254 Q50167 otsA ML2254 Trehalose-6-phosphate synthase (TPS) (EC 2.4.1.15) (EC 2.4.1.347) (Alpha,alpha-trehalose-phosphate synthase [UDP-forming]) (Osmoregulatory trehalose synthesis protein A) (OtsA) 498 57.833 Moderate candidate 0.0282 ProteomeLM contextual shift 0.021840798 1.0 250 1.0 1034 76 0.9618 0.9047 90.47 0.64 1.0 2.4.1.15; 2.4.1.347 PATHWAY: Glycan biosynthesis; trehalose biosynthesis. {ECO:0000250|UniProtKB:P9WN11}. transferase, synthase ProteomeLM contextual percentile 0.03; strong pocket/AF2Bind evidence; essential-process annotation; high-confidence Boltz2 model; matched: transferase, synthase /main_page_ml/ML2254 2026-05-30T13:09:52Z 1206 ML0557 Q9CCP6 lprG ML0557 Lipoarabinomannan carrier protein LprG (27 kDa lipoprotein) (Antigen P27) (Lipoprotein LprG) (Triacylglyceride transfer protein LprG) 238 57.767 Moderate candidate 0.354 ProteomeLM contextual shift 0.08656306 1.0 30 1.0 735 42 0.9051 0.8352 83.52 0.17 0.8625 cell wall, lipoarabinomannan ProteomeLM contextual percentile 0.35; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: cell wall, lipoarabinomannan /main_page_ml/ML0557 2026-05-30T13:09:52Z 1207 ML0281 Q7AQK4 ML0281 DAGKc domain-containing protein 229 57.758 Moderate candidate 0.438 ProteomeLM contextual shift 0.0964837 1.0 26 1.0 730 6 0.6384 0.8804 88.04 0.0 0.8625 ProteomeLM contextual percentile 0.44; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML0281 2026-05-30T13:09:52Z 1208 ML1994 Q7AQ08 fadD10 ML1994 Acyl-CoA synthase 532 57.758 Moderate candidate 0.3609 ProteomeLM contextual shift 0.087458484 1.0 125 1.0 1651 110 0.9487 0.8526 85.26 0.08 1.0 ligase, synthase ProteomeLM contextual percentile 0.36; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: ligase, synthase /main_page_ml/ML1994 2026-05-30T13:09:52Z 1209 ML0598 Q7AQH3 ML0598 MIP18 family-like domain-containing protein 115 57.713 Moderate candidate 0.463 ProteomeLM contextual shift 0.09927374 1.0 14 1.0 361 32 0.8885 0.8931 89.31 0.0 0.7575 ProteomeLM contextual percentile 0.46; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML0598 2026-05-30T13:09:52Z 1210 ML1639 O69481 ML1639 MLCB1243.36 GTP cyclohydrolase 1 type 2 homolog 385 57.686 Moderate candidate 0.2782 ProteomeLM contextual shift 0.07704445 1.0 146 1.0 796 12 0.81 0.8949 89.49 0.2 1.0 hydrolase ProteomeLM contextual percentile 0.28; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: hydrolase /main_page_ml/ML1639 2026-05-30T13:09:52Z 1211 ML0315 Q7AQJ6 ML0315 Oxidoreductase 304 57.68 Moderate candidate 0.3402 ProteomeLM contextual shift 0.084548995 1.0 22 1.0 629 42 0.8783 0.9172 91.72 0.08 1.0 oxidoreductase, dehydrogenase, reductase ProteomeLM contextual percentile 0.34; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: oxidoreductase, dehydrogenase, reductase /main_page_ml/ML0315 2026-05-30T13:09:52Z 1212 ML0389 Q9CCV1 choD ML0389 Cholesterol oxidase (EC 1.1.3.6) (EC 5.3.3.1) (Cholesterol isomerase) 569 57.663 Moderate candidate 0.1447 ProteomeLM contextual shift 0.05850798 1.0 70 1.0 1750 86 0.7946 0.9597 95.97 0.4 1.0 1.1.3.6; 5.3.3.1 PATHWAY: Steroid metabolism; cholesterol degradation. {ECO:0000256|ARBA:ARBA00049645}. oxidoreductase, isomerase, reductase ProteomeLM contextual percentile 0.14; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model; matched: oxidoreductase, isomerase, reductase /main_page_ml/ML0389 2026-05-30T13:09:52Z 1213 ML0100 Q9CDB2 fadD32 ML0100 Acyl-AMP synthetase 635 57.659 Moderate candidate 0.2074 ProteomeLM contextual shift 0.067170635 1.0 108 1.0 1920 30 0.701 0.88 88.0 0.33 1.0 PATHWAY: Lipid metabolism. {ECO:0000256|ARBA:ARBA00005189}. cell wall, lipid metabolism, enzyme, ligase, transferase ProteomeLM contextual percentile 0.21; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: cell wall, lipid metabolism, enzyme, ligase, transferase /main_page_ml/ML0100 2026-05-30T13:09:52Z 1214 ML0792 Q9CCI3 aroA ML0792 3-phosphoshikimate 1-carboxyvinyltransferase (EC 2.5.1.19) (5-enolpyruvylshikimate-3-phosphate synthase) (EPSP synthase) (EPSPS) 430 57.654 Moderate candidate 0.0213 ProteomeLM contextual shift 0.018770346 1.0 28 1.0 877 34 0.8901 0.9109 91.09 0.64 1.0 2.5.1.19 PATHWAY: Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 6/7. {ECO:0000255|HAMAP-Rule:MF_00210}. transferase, synthase ProteomeLM contextual percentile 0.02; strong pocket/AF2Bind evidence; essential-process annotation; high-confidence Boltz2 model; matched: transferase, synthase /main_page_ml/ML0792 2026-05-30T13:09:52Z 1215 ML2323 Q9CB77 ask ML2323 Aspartokinase (EC 2.7.2.4) 421 57.572 Moderate candidate 0.0232 ProteomeLM contextual shift 0.019369552 1.0 148 1.0 1325 124 0.9738 0.8961 89.61 0.64 1.0 2.7.2.4 PATHWAY: Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 1/4. {ECO:0000256|ARBA:ARBA00004766, ECO:0000256|RuleBase:RU004249}.; PATHWAY: Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 1/3. {ECO:0000256|ARBA:ARBA00004986, ECO:0000256|RuleBase:RU004249}.; PATHWAY: Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 1/5. {ECO:0000256|ARBA:ARBA00005139, ECO:0000256|RuleBase:RU004249}. kinase ProteomeLM contextual percentile 0.02; strong pocket/AF2Bind evidence; essential-process annotation; high-confidence Boltz2 model; matched: kinase /main_page_ml/ML2323 2026-05-30T13:09:52Z 1216 ML1142 P53006 atpFH atpF atpH ML1142 ATP synthase subunit b-delta [Includes: ATP synthase subunit b (ATP synthase F(0) sector subunit b 2) (ATPase subunit I 2) (F-type ATPase subunit b 2) (F-ATPase subunit b 2); ATP synthase subunit delta (ATP synthase F(1) sector subunit delta) (F-type ATPase subunit delta) (F-ATPase subunit delta)] 446 57.571 Moderate candidate 0.3722 ProteomeLM contextual shift 0.0889119 1.0 48 1.0 1362 8 0.5963 0.7045 70.45 0.125 1.0 atp synthase, synthase ProteomeLM contextual percentile 0.37; strong pocket/AF2Bind evidence; matched: atp synthase, synthase /main_page_ml/ML1142 2026-05-30T13:09:52Z 1217 ML1255 Q9CC58 ML1255 DUF5130 domain-containing protein 163 57.551 Moderate candidate 0.4737 ProteomeLM contextual shift 0.10032247 1.0 16 1.0 534 90 0.992 0.7347 73.47 0.0 0.8625 ProteomeLM contextual percentile 0.47; strong pocket/AF2Bind evidence /main_page_ml/ML1255 2026-05-30T13:09:52Z 1218 ML0731 P53002 accD5 pccB ML0731 B1308_C1_125 Biotin-dependent acetyl-/propionyl-coenzyme A carboxylase beta5 subunit (Acetyl-CoA carboxylase) (ACC) (EC 2.1.3.15) (Propionyl-CoA carboxylase) (PCC) (EC 2.1.3.-) 549 57.547 Moderate candidate 0.0351 ProteomeLM contextual shift 0.025106885 1.0 314 1.0 1652 10 0.7664 0.9119 91.19 0.61 1.0 2.1.3.-; 2.1.3.15 PATHWAY: Lipid metabolism; mycolic acid biosynthesis. {ECO:0000250|UniProtKB:P9WQH7}. mycolic, lipid metabolism, enzyme, transferase ProteomeLM contextual percentile 0.04; strong pocket/AF2Bind evidence; essential-process annotation; high-confidence Boltz2 model; matched: mycolic, lipid metabolism, enzyme, transferase /main_page_ml/ML0731 2026-05-30T13:09:52Z 1219 ML0286 O69600 fba ML0286 MLCB4.29c Fructose-bisphosphate aldolase (FBP aldolase) (FBPA) (EC 4.1.2.13) (Fructose-1,6-bisphosphate aldolase) 345 57.511 Moderate candidate 0.0088 ProteomeLM contextual shift 0.010611468 1.0 93 1.0 1069 68 0.9444 0.9404 94.04 0.64 1.0 4.1.2.13 PATHWAY: Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 4/4. cofactor ProteomeLM contextual percentile 0.01; strong pocket/AF2Bind evidence; essential-process annotation; high-confidence Boltz2 model; matched: cofactor /main_page_ml/ML0286 2026-05-30T13:09:52Z 1220 ML1576 Q9CBU7 mapB map ML1576 Methionine aminopeptidase (MAP) (MetAP) (EC 3.4.11.18) (Peptidase M) 285 57.5 Moderate candidate 0.0909 ProteomeLM contextual shift 0.04597447 1.0 48 1.0 924 138 0.9826 0.972 97.2 0.48 1.0 3.4.11.18 enzyme, protease, binding site ProteomeLM contextual percentile 0.09; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model; matched: enzyme, protease, binding site /main_page_ml/ML1576 2026-05-30T13:09:52Z 1221 ML0227 Q7AQL4 ML0227 Membrane protein 158 57.496 Moderate candidate 0.4536 ProteomeLM contextual shift 0.09794802 1.0 32 1.0 513 78 0.8585 0.7993 79.93 0.0 0.8625 ProteomeLM contextual percentile 0.45; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML0227 2026-05-30T13:09:52Z 1222 ML0366 Q49869 glmM ML0366 Phosphoglucosamine mutase (EC 5.4.2.10) 463 57.466 Moderate candidate 0.089 ProteomeLM contextual shift 0.045759525 1.0 78 1.0 1434 90 0.9551 0.8852 88.52 0.525 1.0 5.4.2.10 peptidoglycan, cofactor ProteomeLM contextual percentile 0.09; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model; matched: peptidoglycan, cofactor /main_page_ml/ML0366 2026-05-30T13:09:52Z 1223 ML0161 Q9Z5H5 purH ML0161 MLCB373.09 Bifunctional purine biosynthesis protein PurH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase (EC 2.1.2.3) (AICAR transformylase); IMP cyclohydrolase (EC 3.5.4.10) (ATIC) (IMP synthase) (Inosinicase)] 527 57.39 Moderate candidate 0.0514 ProteomeLM contextual shift 0.033937372 1.0 151 1.0 1597 32 0.7676 0.9291 92.91 0.565 1.0 2.1.2.3; 3.5.4.10 PATHWAY: Purine metabolism; IMP biosynthesis via de novo pathway; 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide (10-formyl THF route): step 1/1. {ECO:0000255|HAMAP-Rule:MF_00139}.; PATHWAY: Purine metabolism; IMP biosynthesis via de novo pathway; IMP from 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide: step 1/1. {ECO:0000255|HAMAP-Rule:MF_00139}. folate, transferase, hydrolase, synthase ProteomeLM contextual percentile 0.05; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model; matched: folate, transferase, hydrolase, synthase /main_page_ml/ML0161 2026-05-30T13:09:52Z 1224 ML1751 Q9CBP5 ML1751 THIF-type NAD/FAD binding fold domain-containing protein 721 57.356 Moderate candidate 0.3195 ProteomeLM contextual shift 0.08109226 1.0 92 1.0 1463 2 0.6261 0.8672 86.72 0.125 1.0 nad, enzyme, oxidoreductase, reductase ProteomeLM contextual percentile 0.32; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: nad, enzyme, oxidoreductase, reductase /main_page_ml/ML1751 2026-05-30T13:09:52Z 1225 ML1277 Q9CC49 pykA ML1277 Pyruvate kinase (EC 2.7.1.40) 472 57.353 Moderate candidate 0.0721 ProteomeLM contextual shift 0.040780563 1.0 170 1.0 952 16 0.8362 0.9431 94.31 0.52 1.0 2.7.1.40 PATHWAY: Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 5/5. {ECO:0000256|ARBA:ARBA00004997, ECO:0000256|RuleBase:RU000504}. kinase, cofactor ProteomeLM contextual percentile 0.07; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model; matched: kinase, cofactor /main_page_ml/ML1277 2026-05-30T13:09:52Z 1226 ML1964 Q9CBH7 rmlB ML1964 dTDP-glucose 4,6-dehydratase (EC 4.2.1.46) 333 57.328 Moderate candidate 0.1366 ProteomeLM contextual shift 0.057082776 1.0 76 1.0 720 108 0.9876 0.9447 94.47 0.405 1.0 4.2.1.46 nad, cofactor ProteomeLM contextual percentile 0.14; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model; matched: nad, cofactor /main_page_ml/ML1964 2026-05-30T13:09:52Z 1227 ML2380 Q9CB68 ML2380 Possible secreted protein 153 57.311 Moderate candidate 0.4361 ProteomeLM contextual shift 0.09626595 1.0 12 1.0 469 20 0.7446 0.8422 84.22 0.0 0.8625 ProteomeLM contextual percentile 0.44; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML2380 2026-05-30T13:09:52Z 1228 ML2446 Q9CB49 ML2446 Possible lipoprotein 441 57.254 Moderate candidate 0.146 ProteomeLM contextual shift 0.058900844 1.0 56 1.0 1365 4 0.5246 0.8145 81.45 0.45 1.0 PATHWAY: Cell wall biogenesis; peptidoglycan biosynthesis. {ECO:0000256|ARBA:ARBA00004752, ECO:0000256|PROSITE-ProRule:PRU01373}.; PATHWAY: Glycan biosynthesis. {ECO:0000256|ARBA:ARBA00060592}. peptidoglycan, cell wall, transferase ProteomeLM contextual percentile 0.15; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model; matched: peptidoglycan, cell wall, transferase /main_page_ml/ML2446 2026-05-30T13:09:52Z 1229 ML1314 Q7AQ70 ML1314 DUF503 domain-containing protein 97 57.248 Moderate candidate 0.4323 ProteomeLM contextual shift 0.0956454 1.0 8 1.0 317 52 0.8975 0.9541 95.41 0.0 0.7575 ProteomeLM contextual percentile 0.43; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML1314 2026-05-30T13:09:52Z 1230 ML0536 Q9CCR2 carB ML0536 Carbamoyl phosphate synthase large chain (EC 6.3.4.16) (EC 6.3.5.5) (Carbamoyl phosphate synthetase ammonia chain) 1121 57.189 Moderate candidate 0.0313 ProteomeLM contextual shift 0.023723084 1.0 200 1.0 3447 0 0.2726 0.9042 90.42 0.64 0.925 6.3.4.16; 6.3.5.5 PATHWAY: Amino-acid biosynthesis; L-arginine biosynthesis; carbamoyl phosphate from bicarbonate: step 1/1. {ECO:0000255|HAMAP-Rule:MF_01210}.; PATHWAY: Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 1/3. {ECO:0000255|HAMAP-Rule:MF_01210}. synthetase, synthase, cofactor ProteomeLM contextual percentile 0.03; strong pocket/AF2Bind evidence; essential-process annotation; high-confidence Boltz2 model; matched: synthetase, synthase, cofactor /main_page_ml/ML0536 2026-05-30T13:09:52Z 1231 ML0862 Q7AQE6 ephD ML0862 Oxidoreductase 596 57.187 Moderate candidate 0.3252 ProteomeLM contextual shift 0.081641555 1.0 138 1.0 1817 58 0.933 0.9206 92.06 0.08 1.0 oxidoreductase, dehydrogenase, reductase ProteomeLM contextual percentile 0.33; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: oxidoreductase, dehydrogenase, reductase /main_page_ml/ML0862 2026-05-30T13:09:52Z 1232 ML0747 Q9CCL1 ctpC ML0747 Manganese-exporting P-type ATPase (EC 7.2.2.22) 725 57.146 Moderate candidate 0.1353 ProteomeLM contextual shift 0.056957506 1.0 155 1.0 2235 0 0.3563 0.781 78.1 0.48 1.0 7.2.2.22 ProteomeLM contextual percentile 0.14; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model /main_page_ml/ML0747 2026-05-30T13:09:52Z 1233 ML0200 O69548 topA ML0200 MLCB2548.31c DNA topoisomerase 1 (EC 5.6.2.1) (DNA topoisomerase I) (Omega-protein) (Relaxing enzyme) (Swivelase) (Untwisting enzyme) 947 57.079 Moderate candidate 0.1216 ProteomeLM contextual shift 0.053013813 1.0 146 1.0 2882 2 0.6258 0.8075 80.75 0.525 0.925 5.6.2.1 topoisomerase, enzyme, isomerase, cofactor ProteomeLM contextual percentile 0.12; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model; matched: topoisomerase, enzyme, isomerase, cofactor /main_page_ml/ML0200 2026-05-30T13:09:52Z 1234 ML0079 Q9CDC3 ML0079 Phosphoglycerate mutase 231 57.067 Moderate candidate 0.3772 ProteomeLM contextual shift 0.089752704 1.0 46 1.0 733 80 0.8641 0.864 86.4 0.08 0.8625 ProteomeLM contextual percentile 0.38; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML0079 2026-05-30T13:09:52Z 1235 ML1246 Q9X7B0 plsB ML1246 MLCB1610.07 Glycerol-3-phosphate acyltransferase (GPAT) (EC 2.3.1.15) 775 57.053 Moderate candidate 0.0746 ProteomeLM contextual shift 0.04173339 1.0 152 1.0 2385 0 0.373 0.8893 88.93 0.565 0.925 2.3.1.15 PATHWAY: Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 1/3. lipid metabolism, transferase ProteomeLM contextual percentile 0.07; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model; matched: lipid metabolism, transferase /main_page_ml/ML1246 2026-05-30T13:09:52Z 1236 ML1145 P45823 atpD ML1145 ATP synthase subunit beta (EC 7.1.2.2) (ATP synthase F1 sector subunit beta) (F-ATPase subunit beta) 485 57.038 Moderate candidate 0.0821 ProteomeLM contextual shift 0.043401916 1.0 89 1.0 980 20 0.8911 0.8665 86.65 0.525 1.0 7.1.2.2 atp synthase, synthase ProteomeLM contextual percentile 0.08; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model; matched: atp synthase, synthase /main_page_ml/ML1145 2026-05-30T13:09:52Z 1237 ML2432 P54581 ML2432 B2168_C2_210 Uncharacterized protein ML2432 280 57.034 Moderate candidate 0.3997 ProteomeLM contextual shift 0.09236568 1.0 42 1.0 916 152 0.9923 0.9417 94.17 0.0 0.8625 ProteomeLM contextual percentile 0.40; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML2432 2026-05-30T13:09:52Z 1238 ML1090 Q9CCA0 corA ML1090 Magnesium transport protein CorA 369 57.032 Moderate candidate 0.3277 ProteomeLM contextual shift 0.08216025 1.0 132 1.0 1129 4 0.5434 0.7938 79.38 0.2 0.8625 ProteomeLM contextual percentile 0.33; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML1090 2026-05-30T13:09:52Z 1239 ML0737 P46703 fadE25 acd ML0737 B1308_F1_34 Probable acyl-CoA dehydrogenase fadE25 (EC 1.3.99.-) 389 57.032 Moderate candidate 0.151 ProteomeLM contextual shift 0.05946245 1.0 172 1.0 1235 136 0.966 0.9547 95.47 0.36 1.0 1.3.99.- dehydrogenase, cofactor ProteomeLM contextual percentile 0.15; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model; matched: dehydrogenase, cofactor /main_page_ml/ML0737 2026-05-30T13:09:52Z 1240 ML1454 Q9CBZ8 nadD ML1454 Probable nicotinate-nucleotide adenylyltransferase (EC 2.7.7.18) (Deamido-NAD(+) diphosphorylase) (Deamido-NAD(+) pyrophosphorylase) (Nicotinate mononucleotide adenylyltransferase) (NaMN adenylyltransferase) 214 57.02 Moderate candidate 0.0545 ProteomeLM contextual shift 0.03511131 1.0 70 1.0 693 102 0.9915 0.7912 79.12 0.61 1.0 2.7.7.18 PATHWAY: Cofactor biosynthesis; NAD(+) biosynthesis; deamido-NAD(+) from nicotinate D-ribonucleotide: step 1/1. nad, cofactor biosynthesis, transferase, cofactor ProteomeLM contextual percentile 0.05; strong pocket/AF2Bind evidence; essential-process annotation; high-confidence Boltz2 model; matched: nad, cofactor biosynthesis, transferase, cofactor /main_page_ml/ML1454 2026-05-30T13:09:52Z 1241 ML1143 P45825 atpA ML1143 ATP synthase subunit alpha (EC 7.1.2.2) (ATP synthase F1 sector subunit alpha) (F-ATPase subunit alpha) 558 57.009 Moderate candidate 0.0808 ProteomeLM contextual shift 0.04334757 1.0 104 1.0 1156 0 0.3722 0.868 86.8 0.525 1.0 7.1.2.2 atp synthase, synthase ProteomeLM contextual percentile 0.08; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model; matched: atp synthase, synthase /main_page_ml/ML1143 2026-05-30T13:09:52Z 1242 ML1397 Q9CC19 tsnR ML1397 rRNA methyltransferase 259 56.999 Moderate candidate 0.3152 ProteomeLM contextual shift 0.08082159 1.0 58 1.0 782 10 0.7098 0.9368 93.68 0.08 1.0 transferase ProteomeLM contextual percentile 0.32; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: transferase /main_page_ml/ML1397 2026-05-30T13:09:52Z 1243 ML2358 Q7APV7 fadD26 ML2358 Probable acyl-CoA synthase 583 56.997 Moderate candidate 0.3001 ProteomeLM contextual shift 0.0791698 1.0 80 1.0 1782 66 0.7341 0.8992 89.92 0.125 1.0 cell wall, enzyme, ligase, transferase ProteomeLM contextual percentile 0.30; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: cell wall, enzyme, ligase, transferase /main_page_ml/ML2358 2026-05-30T13:09:52Z 1244 ML0667 O32885 prfB ML0667 MLCB1779.24c Peptide chain release factor 2 (RF-2) 374 56.993 Moderate candidate 0.3716 ProteomeLM contextual shift 0.08889419 1.0 28 1.0 1144 4 0.5665 0.7864 78.64 0.125 0.8625 translation ProteomeLM contextual percentile 0.37; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: translation /main_page_ml/ML0667 2026-05-30T13:09:52Z 1245 ML1899 Q9CBK5 lipG ML1899 Probable hydrolase 304 56.988 Moderate candidate 0.3108 ProteomeLM contextual shift 0.08018166 1.0 26 1.0 1042 260 0.9947 0.9511 95.11 0.08 1.0 hydrolase ProteomeLM contextual percentile 0.31; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: hydrolase /main_page_ml/ML1899 2026-05-30T13:09:52Z 1246 ML1095 Q9CC97 kgd ML1095 Multifunctional 2-oxoglutarate metabolism enzyme (2-hydroxy-3-oxoadipate synthase) (HOA synthase) (HOAS) (EC 2.2.1.5) (2-oxoglutarate carboxy-lyase) (2-oxoglutarate decarboxylase) (Alpha-ketoglutarate decarboxylase) (KG decarboxylase) (KGD) (EC 4.1.1.71) (Alpha-ketoglutarate-glyoxylate carboligase) [Includes: 2-oxoglutarate dehydrogenase E1 component (ODH E1 component) (EC 1.2.4.2) (Alpha-ketoglutarate dehydrogenase E1 component) (KDH E1 component); Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex (EC 2.3.1.61) (2-oxoglutarate dehydrogenase complex E2 component) (ODH E2 component) (OGDC-E2) (Dihydrolipoamide succinyltransferase)] 1238 56.974 Moderate candidate 0.0589 ProteomeLM contextual shift 0.03724486 1.0 318 1.0 1280 0 0.2104 0.8763 87.63 0.64 0.835 1.2.4.2; 2.2.1.5; 2.3.1.61; 4.1.1.71 PATHWAY: Carbohydrate metabolism; tricarboxylic acid cycle; succinate from 2-oxoglutarate (transferase route): step 1/2.; PATHWAY: Carbohydrate metabolism; tricarboxylic acid cycle; succinyl-CoA from 2-oxoglutarate (dehydrogenase route): step 1/1. enzyme, ligase, transferase ProteomeLM contextual percentile 0.06; strong pocket/AF2Bind evidence; essential-process annotation; high-confidence Boltz2 model; matched: enzyme, ligase, transferase /main_page_ml/ML1095 2026-05-30T13:09:52Z 1247 ML0418 Q7AQJ5 ML0418 Oxidoreductase 210 56.835 Moderate candidate 0.3089 ProteomeLM contextual shift 0.080104634 1.0 68 1.0 712 164 0.9957 0.9423 94.23 0.08 1.0 oxidoreductase, reductase ProteomeLM contextual percentile 0.31; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: oxidoreductase, reductase /main_page_ml/ML0418 2026-05-30T13:09:52Z 1248 ML2465 Q9CB37 ML2465 Carboxymuconolactone decarboxylase-like domain-containing protein 188 56.828 Moderate candidate 0.3596 ProteomeLM contextual shift 0.08734741 1.0 28 1.0 629 130 0.9736 0.9015 90.15 0.08 0.8625 ProteomeLM contextual percentile 0.36; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML2465 2026-05-30T13:09:52Z 1249 ML2193 Q9CBC9 mshD ML2193 Mycothiol acetyltransferase (MSH acetyltransferase) (EC 2.3.1.189) (Mycothiol synthase) 311 56.827 Moderate candidate 0.0927 ProteomeLM contextual shift 0.04640364 1.0 38 1.0 1023 180 0.9918 0.8981 89.81 0.48 1.0 2.3.1.189 transferase, synthase ProteomeLM contextual percentile 0.09; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model; matched: transferase, synthase /main_page_ml/ML2193 2026-05-30T13:09:52Z 1250 ML1396 Q9CC20 rplT ML1396 Large ribosomal subunit protein bL20 (50S ribosomal protein L20) 129 56.794 Moderate candidate 0.3264 ProteomeLM contextual shift 0.08180076 1.0 8 1.0 412 10 0.7022 0.7443 74.43 0.215 0.8625 translation, ribosome, ribosomal ProteomeLM contextual percentile 0.33; strong pocket/AF2Bind evidence; matched: translation, ribosome, ribosomal /main_page_ml/ML1396 2026-05-30T13:09:52Z 1251 ML0429 Q7AQJ3 ML0429 Oxidoreductase 268 56.763 Moderate candidate 0.334 ProteomeLM contextual shift 0.08337272 1.0 54 1.0 894 180 0.9959 0.8475 84.75 0.08 1.0 oxidoreductase, dehydrogenase, reductase ProteomeLM contextual percentile 0.33; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: oxidoreductase, dehydrogenase, reductase /main_page_ml/ML0429 2026-05-30T13:09:52Z 1252 ML0153 Q9CD72 uvrD ML0153 ATP-dependent DNA helicase UvrD1 (EC 5.6.2.4) (DNA 3'-5' helicase UvrD1) 778 56.733 Moderate candidate 0.1372 ProteomeLM contextual shift 0.057179715 1.0 172 1.0 2346 24 0.7967 0.8081 80.81 0.48 0.925 5.6.2.4 cofactor ProteomeLM contextual percentile 0.14; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model; matched: cofactor /main_page_ml/ML0153 2026-05-30T13:09:52Z 1253 ML1249 Q7AQ79 ML1249 Uncharacterized protein 1622 56.714 Moderate candidate 0.369 ProteomeLM contextual shift 0.088648416 1.0 261 1.0 0 0 0.0 0.7947 79.47 0.125 0.835 nad, transferase, dehydrogenase ProteomeLM contextual percentile 0.37; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: nad, transferase, dehydrogenase /main_page_ml/ML1249 2026-05-30T13:09:52Z 1254 ML1298 Q9CC41 ML1298 Phosphoglycerate mutase 250 56.706 Moderate candidate 0.3791 ProteomeLM contextual shift 0.08997683 1.0 20 1.0 783 66 0.9723 0.8214 82.14 0.08 0.8625 ProteomeLM contextual percentile 0.38; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML1298 2026-05-30T13:09:52Z 1255 ML1890 P30761 rpoC ML1890 DNA-directed RNA polymerase subunit beta' (RNAP subunit beta') (EC 2.7.7.6) (RNA polymerase subunit beta') (Transcriptase subunit beta') 1316 56.695 Moderate candidate 0.1128 ProteomeLM contextual shift 0.05037591 1.0 189 1.0 1336 0 0.4434 0.7998 79.98 0.57 0.835 2.7.7.6 rna polymerase, transcription, cofactor ProteomeLM contextual percentile 0.11; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model; matched: rna polymerase, transcription, cofactor /main_page_ml/ML1890 2026-05-30T13:09:52Z 1256 ML2627 Q7APS9 ML2627 Acyl dehydratase 339 56.656 Moderate candidate 0.3922 ProteomeLM contextual shift 0.09184582 1.0 115 1.0 695 34 0.8931 0.9303 93.03 0.0 0.8625 ProteomeLM contextual percentile 0.39; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML2627 2026-05-30T13:09:52Z 1257 ML2274 Q9CBA7 ML2274 Secreted protein 112 56.625 Moderate candidate 0.4549 ProteomeLM contextual shift 0.09803912 1.0 10 1.0 354 36 0.8253 0.8129 81.29 0.0 0.7575 ProteomeLM contextual percentile 0.45; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML2274 2026-05-30T13:09:52Z 1258 ML0377 Q49864 tsaE ML0377 B229_C2_205 u229f tRNA threonylcarbamoyladenosine biosynthesis protein TsaE (t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaE) 161 56.607 Moderate candidate 0.3014 ProteomeLM contextual shift 0.07922153 1.0 24 1.0 496 26 0.7868 0.8434 84.34 0.2 0.8625 ProteomeLM contextual percentile 0.30; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML0377 2026-05-30T13:09:52Z 1259 ML2394 P46807 metB ML2394 Cystathionine gamma-synthase (CGS) (EC 2.5.1.48) (O-succinylhomoserine (thiol)-lyase) 388 56.587 Moderate candidate 0.1422 ProteomeLM contextual shift 0.058092535 1.0 161 1.0 794 36 0.8404 0.9409 94.09 0.36 1.0 2.5.1.48 enzyme, lyase, synthase ProteomeLM contextual percentile 0.14; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model; matched: enzyme, lyase, synthase /main_page_ml/ML2394 2026-05-30T13:09:52Z 1260 ML1713 Q7AQ25 ML1713 Methyltransferase type 11 domain-containing protein 280 56.569 Moderate candidate 0.3377 ProteomeLM contextual shift 0.08435089 1.0 50 1.0 602 84 0.9969 0.8148 81.48 0.08 1.0 transferase ProteomeLM contextual percentile 0.34; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: transferase /main_page_ml/ML1713 2026-05-30T13:09:52Z 1261 ML1506 Q9CBW8 ML1506 Secreted protein 348 56.568 Moderate candidate 0.5107 ProteomeLM contextual shift 0.10401422 1.0 36 1.0 714 36 0.8279 0.507 50.7 0.0 0.8625 ProteomeLM contextual percentile 0.51; strong pocket/AF2Bind evidence /main_page_ml/ML1506 2026-05-30T13:09:52Z 1262 ML2568 Q7APU1 ML2568 Possible TetR-family transcriptional regulator 208 56.538 Moderate candidate 0.3509 ProteomeLM contextual shift 0.08612261 1.0 46 1.0 668 88 0.9414 0.8133 81.33 0.125 0.8625 transcription ProteomeLM contextual percentile 0.35; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: transcription /main_page_ml/ML2568 2026-05-30T13:09:52Z 1263 ML1706 Q9CBR6 ML1706 Cobalamin-independent methionine synthase MetE C-terminal/archaeal domain-containing protein 337 56.513 Moderate candidate 0.297 ProteomeLM contextual shift 0.07893374 1.0 32 1.0 1047 72 0.9586 0.9518 95.18 0.08 1.0 transferase, synthase ProteomeLM contextual percentile 0.30; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: transferase, synthase /main_page_ml/ML1706 2026-05-30T13:09:52Z 1264 ML2498 Q9CB21 ML2498 Possible enoyl-CoA hydratase 219 56.465 Moderate candidate 0.2932 ProteomeLM contextual shift 0.07864249 1.0 79 1.0 702 90 0.8569 0.9602 96.02 0.08 1.0 isomerase ProteomeLM contextual percentile 0.29; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: isomerase /main_page_ml/ML2498 2026-05-30T13:09:52Z 1265 ML0669 Q7AQG5 ftsE ML0669 Cell division ATP-binding protein FtsE 229 56.429 Moderate candidate 0.2907 ProteomeLM contextual shift 0.07833885 1.0 97 1.0 764 154 0.9862 0.9229 92.29 0.17 0.8625 cell division, fts ProteomeLM contextual percentile 0.29; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: cell division, fts /main_page_ml/ML0669 2026-05-30T13:09:52Z 1266 ML1444 Q9CC04 ML1444 Possible dienelactone hydrolase 232 56.414 Moderate candidate 0.2989 ProteomeLM contextual shift 0.07905516 1.0 26 1.0 739 86 0.9922 0.9354 93.54 0.08 1.0 hydrolase ProteomeLM contextual percentile 0.30; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: hydrolase /main_page_ml/ML1444 2026-05-30T13:09:52Z 1267 ML1630 Q9CBT4 glnE ML1630 Bifunctional glutamine synthetase adenylyltransferase/adenylyl-removing enzyme (ATP:glutamine synthetase adenylyltransferase) (ATase) [Includes: Glutamine synthetase adenylyl-L-tyrosine phosphorylase (EC 2.7.7.89) (Adenylyl removase) (AR) (AT-N); Glutamine synthetase adenylyl transferase (EC 2.7.7.42) (Adenylyl transferase) (AT) (AT-C)] 1004 56.409 Moderate candidate 0.1786 ProteomeLM contextual shift 0.063793205 1.0 236 1.0 3072 0 0.2889 0.8709 87.09 0.36 0.925 2.7.7.42; 2.7.7.89 enzyme, ligase, transferase ProteomeLM contextual percentile 0.18; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model; matched: enzyme, ligase, transferase /main_page_ml/ML1630 2026-05-30T13:09:52Z 1268 ML1411 P57992 argR ML1411 Arginine repressor 167 56.386 Moderate candidate 0.2726 ProteomeLM contextual shift 0.07594924 1.0 78 1.0 536 70 0.8713 0.7521 75.21 0.285 0.8625 PATHWAY: Amino-acid biosynthesis; L-arginine biosynthesis [regulation]. transcription ProteomeLM contextual percentile 0.27; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: transcription /main_page_ml/ML1411 2026-05-30T13:09:52Z 1269 ML1413 Q9CC09 argH ML1413 Argininosuccinate lyase (ASAL) (EC 4.3.2.1) (Arginosuccinase) 470 56.371 Moderate candidate 0.0445 ProteomeLM contextual shift 0.031569164 1.0 202 1.0 1436 12 0.577 0.9414 94.14 0.52 1.0 4.3.2.1 PATHWAY: Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 3/3. {ECO:0000255|HAMAP-Rule:MF_00006}. lyase ProteomeLM contextual percentile 0.04; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model; matched: lyase /main_page_ml/ML1413 2026-05-30T13:09:52Z 1270 ML0284 Q7AQK3 ML0284 DUF3151 domain-containing protein 137 56.358 Moderate candidate 0.386 ProteomeLM contextual shift 0.09080329 1.0 16 1.0 415 8 0.6182 0.9225 92.25 0.0 0.8625 ProteomeLM contextual percentile 0.39; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML0284 2026-05-30T13:09:52Z 1271 ML1258 Q9X7B8 hisC ML1258 MLCB1610.21 Histidinol-phosphate aminotransferase (EC 2.6.1.9) (Imidazole acetol-phosphate transaminase) 377 56.356 Moderate candidate 0.0526 ProteomeLM contextual shift 0.03429375 1.0 49 1.0 1186 110 0.9336 0.9114 91.14 0.52 1.0 2.6.1.9 PATHWAY: Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 7/9. {ECO:0000255|HAMAP-Rule:MF_01023}. transferase, cofactor ProteomeLM contextual percentile 0.05; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model; matched: transferase, cofactor /main_page_ml/ML1258 2026-05-30T13:09:52Z 1272 ML2593 Q9CD10 lprK ML2593 Lipoprotein 392 56.332 Moderate candidate 0.4687 ProteomeLM contextual shift 0.09984946 1.0 30 1.0 807 46 0.9483 0.4704 47.04 0.08 0.8625 ProteomeLM contextual percentile 0.47; strong pocket/AF2Bind evidence /main_page_ml/ML2593 2026-05-30T13:09:52Z 1273 ML2303 Q9CB90 ML2303 Hydrolase 262 56.328 Moderate candidate 0.2976 ProteomeLM contextual shift 0.079037525 1.0 64 1.0 857 142 0.9793 0.9311 93.11 0.08 1.0 hydrolase ProteomeLM contextual percentile 0.30; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: hydrolase /main_page_ml/ML2303 2026-05-30T13:09:52Z 1274 ML2352 Q49938 ML2352 Probable antibiotic resistance efflux protein 331 56.327 Moderate candidate 0.3703 ProteomeLM contextual shift 0.088817276 1.0 58 1.0 675 26 0.8226 0.8142 81.42 0.08 0.8625 ProteomeLM contextual percentile 0.37; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML2352 2026-05-30T13:09:52Z 1275 ML2435 P54579 ML2435 B2168_F1_37 Probable redox regulatory protein ML2435 277 56.323 Moderate candidate 0.4023 ProteomeLM contextual shift 0.09273708 1.0 46 1.0 603 98 0.995 0.8619 86.19 0.0 0.8625 ProteomeLM contextual percentile 0.40; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML2435 2026-05-30T13:09:52Z 1276 ML1682 Q9CBR8 ML1682 Nudix hydrolase domain-containing protein 311 56.302 Moderate candidate 0.3095 ProteomeLM contextual shift 0.08010767 1.0 52 1.0 993 0 0.4442 0.8869 88.69 0.08 1.0 hydrolase ProteomeLM contextual percentile 0.31; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: hydrolase /main_page_ml/ML1682 2026-05-30T13:09:52Z 1277 ML2378 P54881 mmpL4 ML2378 u1740v Probable transport protein MmpL4 959 56.24 Moderate candidate 0.3578 ProteomeLM contextual shift 0.08708797 1.0 136 1.0 2937 0 0.4337 0.8343 83.43 0.125 0.7875 cell division ProteomeLM contextual percentile 0.36; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: cell division /main_page_ml/ML2378 2026-05-30T13:09:52Z 1278 ML1988 Q9CBG8 ML1988 Probable integral membrane protein 237 56.207 Moderate candidate 0.4831 ProteomeLM contextual shift 0.10128212 1.0 18 1.0 718 14 0.9076 0.5674 56.74 0.0 0.8625 ProteomeLM contextual percentile 0.48; strong pocket/AF2Bind evidence /main_page_ml/ML1988 2026-05-30T13:09:52Z 1279 ML2691 Q9CCY3 ML2691 Transcription regulator PadR N-terminal domain-containing protein 180 56.206 Moderate candidate 0.3734 ProteomeLM contextual shift 0.08911256 1.0 44 1.0 563 46 0.9363 0.8611 86.11 0.045 0.8625 transcription ProteomeLM contextual percentile 0.37; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: transcription /main_page_ml/ML2691 2026-05-30T13:09:52Z 1280 ML0765 Q9CCJ5 manA ML0765 mannose-6-phosphate isomerase (EC 5.3.1.8) 410 56.171 Moderate candidate 0.0639 ProteomeLM contextual shift 0.038344998 1.0 58 1.0 1252 44 0.7575 0.9334 93.34 0.48 1.0 5.3.1.8 isomerase, cofactor ProteomeLM contextual percentile 0.06; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model; matched: isomerase, cofactor /main_page_ml/ML0765 2026-05-30T13:09:52Z 1281 ML1900 Q9CBK4 mmaA1 ML1900 Methyl mycolic acid synthase 1 286 56.159 Moderate candidate 0.2018 ProteomeLM contextual shift 0.06652173 1.0 44 1.0 927 138 0.9996 0.9198 91.98 0.245 1.0 mycolic, transferase, synthase ProteomeLM contextual percentile 0.20; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: mycolic, transferase, synthase /main_page_ml/ML1900 2026-05-30T13:09:52Z 1282 ML1812 Q9CBL5 ML1812 Exported p60 protein homologue 479 56.095 Moderate candidate 0.3797 ProteomeLM contextual shift 0.0901443 1.0 46 1.0 973 30 0.8575 0.6681 66.81 0.125 0.8625 cell wall ProteomeLM contextual percentile 0.38; strong pocket/AF2Bind evidence; matched: cell wall /main_page_ml/ML1812 2026-05-30T13:09:52Z 1283 ML0314 Q7AQJ7 ML0314 Esterase 335 56.064 Moderate candidate 0.2337 ProteomeLM contextual shift 0.07027288 1.0 32 1.0 1116 222 0.9976 0.8885 88.85 0.2 1.0 enzyme ProteomeLM contextual percentile 0.23; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: enzyme /main_page_ml/ML0314 2026-05-30T13:09:52Z 1284 ML1544 Q7AQ46 ML1544 Conserved membrane protein 506 56.061 Moderate candidate 0.3296 ProteomeLM contextual shift 0.082424335 1.0 34 1.0 1052 0 0.3579 0.7926 79.26 0.08 1.0 hydrolase ProteomeLM contextual percentile 0.33; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: hydrolase /main_page_ml/ML1544 2026-05-30T13:09:52Z 1285 ML1699 Q7AQ26 ML1699 Lipoprotein 372 56.046 Moderate candidate 0.4016 ProteomeLM contextual shift 0.0927142 1.0 78 1.0 763 38 0.8297 0.8364 83.64 0.0 0.8625 ProteomeLM contextual percentile 0.40; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML1699 2026-05-30T13:09:52Z 1286 ML1026 Q7AQA9 ML1026 dUTPase 100 56.04 Moderate candidate 0.5226 ProteomeLM contextual shift 0.105414 1.0 10 1.0 230 60 0.9513 0.5176 51.76 0.0 0.7575 ProteomeLM contextual percentile 0.52; strong pocket/AF2Bind evidence /main_page_ml/ML1026 2026-05-30T13:09:52Z 1287 ML0703 Q9CCL8 ML0703 Primosomal protein 423 56.028 Moderate candidate 0.4261 ProteomeLM contextual shift 0.095035106 1.0 56 1.0 1292 46 0.8269 0.7491 74.91 0.0 0.8625 ProteomeLM contextual percentile 0.43; strong pocket/AF2Bind evidence /main_page_ml/ML0703 2026-05-30T13:09:52Z 1288 ML2594 Q9CD09 mce1F ML2594 Secreted protein 516 56.001 Moderate candidate 0.4693 ProteomeLM contextual shift 0.09986064 1.0 61 1.0 1581 26 0.8048 0.4351 43.51 0.08 0.8625 ProteomeLM contextual percentile 0.47; strong pocket/AF2Bind evidence /main_page_ml/ML2594 2026-05-30T13:09:52Z 1289 ML1833 O33006 secY ML1833 MLCB2492.27 Protein translocase subunit SecY 438 55.997 Moderate candidate 0.381 ProteomeLM contextual shift 0.090297684 1.0 109 1.0 1350 72 0.8881 0.7439 74.39 0.08 0.8625 ProteomeLM contextual percentile 0.38; strong pocket/AF2Bind evidence /main_page_ml/ML1833 2026-05-30T13:09:52Z 1290 ML2186 Q50049 dus ML2186 Probable tRNA-dihydrouridine synthase (EC 1.3.1.-) 384 55.992 Moderate candidate 0.0457 ProteomeLM contextual shift 0.031737242 1.0 60 1.0 1212 120 0.9613 0.8891 88.91 0.525 1.0 1.3.1.- nad, synthase, cofactor ProteomeLM contextual percentile 0.05; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model; matched: nad, synthase, cofactor /main_page_ml/ML2186 2026-05-30T13:09:52Z 1291 ML1027 Q7AQA8 ML1027 Possible membrane protein 157 55.963 Moderate candidate 0.3954 ProteomeLM contextual shift 0.092119195 1.0 18 1.0 481 20 0.7373 0.85 85.0 0.0 0.8625 ProteomeLM contextual percentile 0.40; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML1027 2026-05-30T13:09:52Z 1292 ML0151 Q9CD74 ML0151 Chorismate mutase domain-containing protein 105 55.96 Moderate candidate 0.4085 ProteomeLM contextual shift 0.09311485 1.0 4 1.0 345 60 0.9549 0.7487 74.87 0.08 0.7575 ProteomeLM contextual percentile 0.41; strong pocket/AF2Bind evidence /main_page_ml/ML0151 2026-05-30T13:09:52Z 1293 ML0380 P24301 groES chpA groS mopB ML0380 B1620_C3_227 B229_C3_247 Co-chaperonin GroES (10 kDa antigen) (10 kDa chaperonin) (Chaperonin-10) (Cpn10) 100 55.921 Moderate candidate 0.3985 ProteomeLM contextual shift 0.092275076 1.0 54 1.0 202 4 0.5851 0.7798 77.98 0.08 0.7575 ProteomeLM contextual percentile 0.40; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML0380 2026-05-30T13:09:52Z 1294 ML0182 Q7AQM8 galU ML0182 UTP--glucose-1-phosphate uridylyltransferase (EC 2.7.7.9) 306 55.893 Moderate candidate 0.1297 ProteomeLM contextual shift 0.05533734 1.0 64 1.0 928 20 0.6787 0.9153 91.53 0.36 1.0 2.7.7.9 transferase ProteomeLM contextual percentile 0.13; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model; matched: transferase /main_page_ml/ML0182 2026-05-30T13:09:52Z 1295 ML1896 Q9CBK7 rplJ ML1896 Large ribosomal subunit protein uL10 (50S ribosomal protein L10) 177 55.866 Moderate candidate 0.2957 ProteomeLM contextual shift 0.078805074 1.0 10 1.0 539 16 0.8579 0.759 75.9 0.215 0.8625 translation, ribosome, ribosomal ProteomeLM contextual percentile 0.30; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: translation, ribosome, ribosomal /main_page_ml/ML1896 2026-05-30T13:09:52Z 1296 ML2588 Q9CD15 yrbE1B ML2588 Conserved membrane protein 289 55.844 Moderate candidate 0.3559 ProteomeLM contextual shift 0.0867895 1.0 30 1.0 875 16 0.7888 0.8163 81.63 0.08 0.8625 ProteomeLM contextual percentile 0.36; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML2588 2026-05-30T13:09:52Z 1297 ML1920 Q9CBJ0 mutY ML1920 Adenine DNA glycosylase (EC 3.2.2.31) 297 55.829 Moderate candidate 0.1335 ProteomeLM contextual shift 0.056554165 1.0 46 1.0 618 48 0.9532 0.8958 89.58 0.36 1.0 3.2.2.31 cofactor ProteomeLM contextual percentile 0.13; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model; matched: cofactor /main_page_ml/ML1920 2026-05-30T13:09:52Z 1298 ML2705 Q7APR6 ML2705 Acetyltransferase 259 55.825 Moderate candidate 0.3659 ProteomeLM contextual shift 0.08810274 1.0 28 1.0 805 56 0.956 0.8018 80.18 0.0 1.0 transferase ProteomeLM contextual percentile 0.37; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: transferase /main_page_ml/ML2705 2026-05-30T13:09:52Z 1299 ML0192 Q9CD61 ML0192 Polyprenol-phosphate-mannose--protein mannosyltransferase (EC 2.4.1.-) 510 55.806 Moderate candidate 0.1046 ProteomeLM contextual shift 0.049164083 1.0 114 1.0 1023 6 0.5159 0.9144 91.44 0.4 1.0 2.4.1.- PATHWAY: Protein modification; protein glycosylation. {ECO:0000256|ARBA:ARBA00004922, ECO:0000256|RuleBase:RU367007}. transferase ProteomeLM contextual percentile 0.10; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model; matched: transferase /main_page_ml/ML0192 2026-05-30T13:09:52Z 1300 ML1659 O69469 rnc ML1659 MLCB1243.15 Ribonuclease 3 (EC 3.1.26.3) (Ribonuclease III) (RNase III) 238 55.771 Moderate candidate 0.0796 ProteomeLM contextual shift 0.04257541 1.0 74 1.0 721 14 0.7502 0.8386 83.86 0.48 1.0 3.1.26.3 cofactor ProteomeLM contextual percentile 0.08; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model; matched: cofactor /main_page_ml/ML1659 2026-05-30T13:09:52Z 1301 ML0713 P53435 glpD ML0713 L308_C1_179 Glycerol-3-phosphate dehydrogenase (EC 1.1.5.3) 585 55.71 Moderate candidate 0.0583 ProteomeLM contextual shift 0.037168764 1.0 80 1.0 1794 78 0.8429 0.907 90.7 0.48 1.0 1.1.5.3 dehydrogenase, cofactor ProteomeLM contextual percentile 0.06; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model; matched: dehydrogenase, cofactor /main_page_ml/ML0713 2026-05-30T13:09:52Z 1302 ML2459 Q9CB40 umaA2 ML2459 Mycolic acid synthase 295 55.695 Moderate candidate 0.1867 ProteomeLM contextual shift 0.064360835 1.0 32 1.0 651 122 0.9973 0.926 92.6 0.245 1.0 mycolic, transferase, synthase ProteomeLM contextual percentile 0.19; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: mycolic, transferase, synthase /main_page_ml/ML2459 2026-05-30T13:09:52Z 1303 ML1848 O32994 rplX ML1848 MLCB2492.15 Large ribosomal subunit protein uL24 (50S ribosomal protein L24) 105 55.604 Moderate candidate 0.2863 ProteomeLM contextual shift 0.077913836 1.0 14 1.0 322 14 0.6642 0.8707 87.07 0.215 0.7575 translation, ribosome, ribosomal ProteomeLM contextual percentile 0.29; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: translation, ribosome, ribosomal /main_page_ml/ML1848 2026-05-30T13:09:52Z 1304 ML0245 Q9CD48 rplY ctc ML0245 Large ribosomal subunit protein bL25 (50S ribosomal protein L25) (General stress protein CTC) 215 55.539 Moderate candidate 0.287 ProteomeLM contextual shift 0.0781133 1.0 18 1.0 654 18 0.7141 0.757 75.7 0.215 0.8625 translation, ribosome, ribosomal ProteomeLM contextual percentile 0.29; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: translation, ribosome, ribosomal /main_page_ml/ML0245 2026-05-30T13:09:52Z 1305 ML0243 Q9CD50 ML0243 Acyl-CoA synthetase 544 55.51 Moderate candidate 0.2763 ProteomeLM contextual shift 0.07680874 1.0 76 1.0 1173 170 0.972 0.9239 92.39 0.08 1.0 enzyme, ligase, transferase ProteomeLM contextual percentile 0.28; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: enzyme, ligase, transferase /main_page_ml/ML0243 2026-05-30T13:09:52Z 1306 ML0660 Q7AQG9 fadE23 ML0660 Acyl-CoA dehydrogenase 400 55.508 Moderate candidate 0.2268 ProteomeLM contextual shift 0.06975905 1.0 112 1.0 1309 218 0.9951 0.8569 85.69 0.2 1.0 dehydrogenase, cofactor ProteomeLM contextual percentile 0.23; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: dehydrogenase, cofactor /main_page_ml/ML0660 2026-05-30T13:09:52Z 1307 ML0696 Q7AQF9 sdhB ML0696 succinate dehydrogenase (EC 1.3.5.1) 264 55.499 Moderate candidate 0.1742 ProteomeLM contextual shift 0.06331936 1.0 30 1.0 814 44 0.8212 0.8702 87.02 0.285 1.0 1.3.5.1 respiratory, dehydrogenase, reductase, cofactor ProteomeLM contextual percentile 0.17; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: respiratory, dehydrogenase, reductase, cofactor /main_page_ml/ML0696 2026-05-30T13:09:52Z 1308 ML2613 Q7APT3 ML2613 Probable zinc metalloprotease 667 55.49 Moderate candidate 0.2776 ProteomeLM contextual shift 0.07694366 1.0 154 1.0 2043 84 0.9731 0.9175 91.75 0.08 1.0 protease, cofactor ProteomeLM contextual percentile 0.28; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: protease, cofactor /main_page_ml/ML2613 2026-05-30T13:09:52Z 1309 ML0804 Q9CCH7 whiB1 whiB ML0804 Transcriptional regulator WhiB 84 55.472 Moderate candidate 0.1936 ProteomeLM contextual shift 0.06548409 1.0 50 1.0 265 26 0.7338 0.8945 89.45 0.29 0.895 transcription, nad, reductase, cofactor ProteomeLM contextual percentile 0.19; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: transcription, nad, reductase, cofactor /main_page_ml/ML0804 2026-05-30T13:09:52Z 1310 ML1898 Q9CBK6 ML1898 Protein kinase domain-containing protein 448 55.406 Moderate candidate 0.3051 ProteomeLM contextual shift 0.07953391 1.0 66 1.0 1473 258 0.9737 0.8127 81.27 0.08 1.0 kinase ProteomeLM contextual percentile 0.31; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: kinase /main_page_ml/ML1898 2026-05-30T13:09:52Z 1311 ML0364 P38014 rplM ML0364 B229_C3_232 Large ribosomal subunit protein uL13 (50S ribosomal protein L13) 147 55.393 Moderate candidate 0.2713 ProteomeLM contextual shift 0.07576563 1.0 14 1.0 494 106 0.9855 0.7972 79.72 0.215 0.8625 translation, ribosome, ribosomal ProteomeLM contextual percentile 0.27; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: translation, ribosome, ribosomal /main_page_ml/ML0364 2026-05-30T13:09:52Z 1312 ML0013 Q9CDE7 crgA ML0013 Cell division protein CrgA 93 55.367 Moderate candidate 0.3816 ProteomeLM contextual shift 0.0903287 1.0 10 1.0 502 74 0.8359 0.6936 69.36 0.125 0.7575 cell division ProteomeLM contextual percentile 0.38; strong pocket/AF2Bind evidence; matched: cell division /main_page_ml/ML0013 2026-05-30T13:09:52Z 1313 ML0833 Q9CCG2 dnaG ML0833 DNA primase (EC 2.7.7.101) 642 55.365 Moderate candidate 0.0019 ProteomeLM contextual shift 0.0033214046 1.0 148 1.0 1948 4 0.5902 0.8 80.0 0.615 1.0 2.7.7.101 dna replication, replication, rna polymerase, cofactor ProteomeLM contextual percentile 0.00; strong pocket/AF2Bind evidence; essential-process annotation; high-confidence Boltz2 model; matched: dna replication, replication, rna polymerase, cofactor /main_page_ml/ML0833 2026-05-30T13:09:52Z 1314 ML1631 Q9CBT3 glnA2 ML1631 Glutamine synthetase (EC 6.3.1.2) (Glutamate--ammonia ligase) (Glutamine synthetase I alpha) 448 55.345 Moderate candidate 0.0576 ProteomeLM contextual shift 0.036532126 1.0 62 1.0 1348 8 0.7461 0.8727 87.27 0.48 1.0 6.3.1.2 ligase, synthetase, cofactor ProteomeLM contextual percentile 0.06; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model; matched: ligase, synthetase, cofactor /main_page_ml/ML1631 2026-05-30T13:09:52Z 1315 ML2277 Q9CBA5 ML2277 Polyprenyl diphosphate synthase component 330 55.335 Moderate candidate 0.1523 ProteomeLM contextual shift 0.059758596 1.0 58 1.0 1046 112 0.9281 0.9306 93.06 0.285 1.0 PATHWAY: Isoprenoid biosynthesis. {ECO:0000256|ARBA:ARBA00005128}. isoprenoid, transferase, synthase, cofactor ProteomeLM contextual percentile 0.15; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: isoprenoid, transferase, synthase, cofactor /main_page_ml/ML2277 2026-05-30T13:09:52Z 1316 ML1402 Q9CC16 pheT ML1402 Phenylalanine--tRNA ligase beta subunit (EC 6.1.1.20) (Phenylalanyl-tRNA synthetase beta subunit) (PheRS) 835 55.328 Moderate candidate 0.0508 ProteomeLM contextual shift 0.03383114 1.0 164 1.0 2549 2 0.5023 0.8802 88.02 0.525 0.925 6.1.1.20 trna ligase, ligase, synthetase, cofactor ProteomeLM contextual percentile 0.05; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model; matched: trna ligase, ligase, synthetase, cofactor /main_page_ml/ML1402 2026-05-30T13:09:52Z 1317 ML2654 Q9CCZ0 ML2654 Phosphoesterase (EC 3.1.4.-) 165 55.325 Moderate candidate 0.1685 ProteomeLM contextual shift 0.062875345 1.0 20 1.0 499 8 0.6947 0.9626 96.26 0.24 1.0 3.1.4.- hydrolase, cofactor ProteomeLM contextual percentile 0.17; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: hydrolase, cofactor /main_page_ml/ML2654 2026-05-30T13:09:52Z 1318 ML2565 Q7APU2 fabG4 ML2565 Possible oxidoreductase 454 55.306 Moderate candidate 0.2437 ProteomeLM contextual shift 0.07160794 1.0 134 1.0 1413 102 0.8876 0.9275 92.75 0.125 1.0 nad, oxidoreductase, dehydrogenase, reductase ProteomeLM contextual percentile 0.24; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: nad, oxidoreductase, dehydrogenase, reductase /main_page_ml/ML2565 2026-05-30T13:09:52Z 1319 ML1300 Q9CC40 ML1300 Phosphatidylinositol kinase 262 55.291 Moderate candidate 0.317 ProteomeLM contextual shift 0.08103413 1.0 42 1.0 804 36 0.8354 0.9194 91.94 0.0 1.0 kinase ProteomeLM contextual percentile 0.32; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: kinase /main_page_ml/ML1300 2026-05-30T13:09:52Z 1320 ML0578 P46710 ppc ML0578 B1496_C3_207 Phosphoenolpyruvate carboxylase (PEPC) (PEPCase) (EC 4.1.1.31) 934 55.27 Moderate candidate 0.0739 ProteomeLM contextual shift 0.041094497 1.0 185 1.0 2824 4 0.7249 0.8832 88.32 0.48 0.925 4.1.1.31 cofactor ProteomeLM contextual percentile 0.07; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model; matched: cofactor /main_page_ml/ML0578 2026-05-30T13:09:52Z 1321 ML1312 Q7AQ72 ML1312 PD-(D/E)XK endonuclease-like domain-containing protein 294 55.233 Moderate candidate 0.3315 ProteomeLM contextual shift 0.08282114 1.0 54 1.0 608 40 0.9072 0.8407 84.07 0.08 0.8625 ProteomeLM contextual percentile 0.33; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML1312 2026-05-30T13:09:52Z 1322 ML0597 Q7AQH4 ML0597 NIF system FeS cluster assembly NifU N-terminal domain-containing protein 165 55.17 Moderate candidate 0.3189 ProteomeLM contextual shift 0.081067406 1.0 20 1.0 354 8 0.6816 0.8783 87.83 0.08 0.8625 ProteomeLM contextual percentile 0.32; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML0597 2026-05-30T13:09:52Z 1323 ML2297 Q9CB96 ML2297 Hydrolase 324 55.163 Moderate candidate 0.2663 ProteomeLM contextual shift 0.07544183 1.0 46 1.0 1062 180 0.9992 0.9243 92.43 0.08 1.0 hydrolase ProteomeLM contextual percentile 0.27; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: hydrolase /main_page_ml/ML2297 2026-05-30T13:09:52Z 1324 ML0236 Q7AQL1 pabB ML0236 Para-aminobenzoate synthase component 418 55.145 Moderate candidate 0.2682 ProteomeLM contextual shift 0.07557216 1.0 52 1.0 1269 30 0.8941 0.9159 91.59 0.08 1.0 synthase ProteomeLM contextual percentile 0.27; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: synthase /main_page_ml/ML0236 2026-05-30T13:09:52Z 1325 ML0882 O69582 ctaE ML0882 Probable cytochrome c oxidase subunit 3 (EC 7.1.1.9) (Cytochrome aa3 subunit 3) (Cytochrome c oxidase polypeptide III) 202 55.137 Moderate candidate 0.1322 ProteomeLM contextual shift 0.05624482 1.0 28 1.0 627 42 0.8089 0.831 83.1 0.36 1.0 7.1.1.9 ProteomeLM contextual percentile 0.13; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model /main_page_ml/ML0882 2026-05-30T13:09:52Z 1326 ML2434 P54882 ML2434 B2168_C2_208 Exopolyphosphatase 1 (ExopolyPase 1) (EC 3.6.1.11) 339 55.128 Moderate candidate 0.1172 ProteomeLM contextual shift 0.05224265 1.0 36 1.0 1040 46 0.9318 0.8827 88.27 0.36 1.0 3.6.1.11 ProteomeLM contextual percentile 0.12; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model /main_page_ml/ML2434 2026-05-30T13:09:52Z 1327 ML2335 Q7APW2 dnaZX dnaX ML2335 DNA polymerase III subunit gamma/tau (EC 2.7.7.7) 611 55.093 Moderate candidate 0.1328 ProteomeLM contextual shift 0.056491014 1.0 54 1.0 1840 14 0.6654 0.6444 64.44 0.45 1.0 2.7.7.7 dna replication, replication ProteomeLM contextual percentile 0.13; strong pocket/AF2Bind evidence; functional annotation support; matched: dna replication, replication /main_page_ml/ML2335 2026-05-30T13:09:52Z 1328 ML1951 Q7AQ12 phoH2 ML1951 Protein PhoH2 (EC 5.6.2.5) (RNA 5'-3' helicase PhoH2) (Toxin PhoP2) 433 55.085 Moderate candidate 0.1347 ProteomeLM contextual shift 0.05687226 1.0 88 1.0 1322 6 0.6632 0.8171 81.71 0.36 1.0 5.6.2.5 hydrolase, cofactor ProteomeLM contextual percentile 0.13; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model; matched: hydrolase, cofactor /main_page_ml/ML1951 2026-05-30T13:09:52Z 1329 ML2564 Q7APU3 fadA2 ML2564 Acetyl-CoA C-acetyltransferase 457 55.081 Moderate candidate 0.2751 ProteomeLM contextual shift 0.07660184 1.0 190 1.0 943 58 0.9387 0.8854 88.54 0.08 1.0 transferase ProteomeLM contextual percentile 0.28; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: transferase /main_page_ml/ML2564 2026-05-30T13:09:52Z 1330 ML1200 Q7AQ83 ML1200 Pseudouridine synthase (EC 5.4.99.-) 308 55.062 Moderate candidate 0.0489 ProteomeLM contextual shift 0.032533377 1.0 38 1.0 967 86 0.9641 0.8751 87.51 0.48 1.0 5.4.99.- enzyme, synthase ProteomeLM contextual percentile 0.05; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model; matched: enzyme, synthase /main_page_ml/ML1200 2026-05-30T13:09:52Z 1331 ML1505 Q9CBW9 ML1505 Conserved hypothetical Proline rich protein 182 55.054 Moderate candidate 0.5088 ProteomeLM contextual shift 0.103789814 1.0 20 1.0 621 150 0.9712 0.3622 36.22 0.0 0.8625 ProteomeLM contextual percentile 0.51; strong pocket/AF2Bind evidence /main_page_ml/ML1505 2026-05-30T13:09:52Z 1332 ML1857 O32987 rpsC ML1857 MLCB2492.08 Small ribosomal subunit protein uS3 (30S ribosomal protein S3) 281 55.031 Moderate candidate 0.307 ProteomeLM contextual shift 0.079846844 1.0 55 1.0 895 104 0.9437 0.6361 63.61 0.215 0.8625 translation, ribosome, ribosomal ProteomeLM contextual percentile 0.31; strong pocket/AF2Bind evidence; matched: translation, ribosome, ribosomal /main_page_ml/ML1857 2026-05-30T13:09:52Z 1333 ML0885 Q7AQE3 ML0885 Secreted protein 374 55.02 Moderate candidate 0.3503 ProteomeLM contextual shift 0.08599665 1.0 30 1.0 1146 8 0.5477 0.7536 75.36 0.08 0.8625 ProteomeLM contextual percentile 0.35; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML0885 2026-05-30T13:09:52Z 1334 ML1628 O33010 ftsY ML1628 MLCB250.02 Signal recognition particle receptor FtsY (SRP receptor) (EC 3.6.5.4) 430 55.019 Moderate candidate 0.0432 ProteomeLM contextual shift 0.030996667 1.0 40 1.0 900 0 0.3758 0.7105 71.05 0.57 1.0 3.6.5.4 translation, fts ProteomeLM contextual percentile 0.04; strong pocket/AF2Bind evidence; functional annotation support; matched: translation, fts /main_page_ml/ML1628 2026-05-30T13:09:52Z 1335 ML2213 Q50022 apeB pepC pepX ML2213 MLCB5.29 Probable M18 family aminopeptidase 2 (EC 3.4.11.-) 426 55.013 Moderate candidate 0.1034 ProteomeLM contextual shift 0.048818715 1.0 47 1.0 1360 62 0.8554 0.9194 91.94 0.36 1.0 3.4.11.- cofactor ProteomeLM contextual percentile 0.10; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model; matched: cofactor /main_page_ml/ML2213 2026-05-30T13:09:52Z 1336 ML0202 Q7AQM2 ML0202 DNA polymerase III subunit delta' (EC 2.7.7.7) 405 54.996 Moderate candidate 0.0764 ProteomeLM contextual shift 0.04219457 1.0 44 1.0 835 50 0.8933 0.8321 83.21 0.45 1.0 2.7.7.7 dna replication, replication ProteomeLM contextual percentile 0.08; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model; matched: dna replication, replication /main_page_ml/ML0202 2026-05-30T13:09:52Z 1337 ML2667 Q9CCY6 ML2667 Possible membrane transport protein 618 54.972 Moderate candidate 0.349 ProteomeLM contextual shift 0.085743636 1.0 159 1.0 1862 16 0.6379 0.7532 75.32 0.08 0.8625 ProteomeLM contextual percentile 0.35; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML2667 2026-05-30T13:09:52Z 1338 ML0116 Q9CD98 ML0116 Membrane protein 654 54.929 Moderate candidate 0.3415 ProteomeLM contextual shift 0.08481725 1.0 142 1.0 1966 8 0.703 0.9352 93.52 0.0 0.8625 ProteomeLM contextual percentile 0.34; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML0116 2026-05-30T13:09:52Z 1339 ML1234 P54200 fadD21 masC ML1234 Putative fatty-acid--CoA ligase fadD21 (EC 6.2.1.-) (Acyl-CoA synthetase) 579 54.923 Moderate candidate 0.1491 ProteomeLM contextual shift 0.05917382 1.0 94 1.0 1757 40 0.7251 0.9004 90.04 0.285 1.0 6.2.1.- cell wall, enzyme, ligase, transferase ProteomeLM contextual percentile 0.15; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: cell wall, enzyme, ligase, transferase /main_page_ml/ML1234 2026-05-30T13:09:52Z 1340 ML1734 Q9CBQ0 nrdE ML1734 Ribonucleoside-diphosphate reductase subunit alpha (EC 1.17.4.1) (Ribonucleotide reductase R1 subunit) 721 54.916 Moderate candidate 0.0276 ProteomeLM contextual shift 0.02182824 1.0 153 1.0 2110 22 0.8953 0.9351 93.51 0.48 1.0 1.17.4.1 reductase ProteomeLM contextual percentile 0.03; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model; matched: reductase /main_page_ml/ML1734 2026-05-30T13:09:52Z 1341 ML2495 Q9CB23 grpE ML2495 Protein GrpE (HSP-70 cofactor) 229 54.865 Moderate candidate 0.3365 ProteomeLM contextual shift 0.08401234 1.0 66 1.0 709 44 0.8249 0.6489 64.89 0.08 1.0 cofactor ProteomeLM contextual percentile 0.34; strong pocket/AF2Bind evidence; matched: cofactor /main_page_ml/ML2495 2026-05-30T13:09:52Z 1342 ML0371 P40831 glmS ML0371 B229_C3_238 Glutamine--fructose-6-phosphate aminotransferase [isomerizing] (EC 2.6.1.16) (D-fructose-6-phosphate amidotransferase) (GFAT) (Glucosamine-6-phosphate synthase) (Hexosephosphate aminotransferase) (L-glutamine--D-fructose-6-phosphate amidotransferase) 625 54.848 Moderate candidate 0.0414 ProteomeLM contextual shift 0.03002962 1.0 169 1.0 1914 38 0.7664 0.8801 88.01 0.48 1.0 2.6.1.16 transferase, synthase ProteomeLM contextual percentile 0.04; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model; matched: transferase, synthase /main_page_ml/ML0371 2026-05-30T13:09:52Z 1343 ML0185 Q7AQM6 ML0185 Membrane protein 342 54.846 Moderate candidate 0.5056 ProteomeLM contextual shift 0.10357748 1.0 46 1.0 1049 6 0.561 0.3524 35.24 0.0 0.8625 ProteomeLM contextual percentile 0.51; strong pocket/AF2Bind evidence /main_page_ml/ML0185 2026-05-30T13:09:52Z 1344 ML0493 Q49649 ML0493 B1177_C3_247 MLCB1259.11 Uncharacterized protein ML0493 (EC 3.-.-.-) 218 54.822 Moderate candidate 0.0952 ProteomeLM contextual shift 0.046967622 1.0 28 1.0 462 52 0.9231 0.9288 92.88 0.36 1.0 3.-.-.- hydrolase, cofactor ProteomeLM contextual percentile 0.10; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model; matched: hydrolase, cofactor /main_page_ml/ML0493 2026-05-30T13:09:52Z 1345 ML2424 Q49823 ML2424 B2168_F1_26 Putative hydrolase ML2424 (EC 3.1.-.-) 300 54.774 Moderate candidate 0.1504 ProteomeLM contextual shift 0.059355773 1.0 66 1.0 980 160 0.995 0.731 73.1 0.36 1.0 3.1.-.- hydrolase, cofactor ProteomeLM contextual percentile 0.15; strong pocket/AF2Bind evidence; functional annotation support; matched: hydrolase, cofactor /main_page_ml/ML2424 2026-05-30T13:09:52Z 1346 ML0583 P46708 tkt ML0583 B1496_F1_26 MLCL536.38 Transketolase (TK) (EC 2.2.1.1) 699 54.706 Moderate candidate 0.0119 ProteomeLM contextual shift 0.013545897 1.0 232 1.0 2157 0 0.4134 0.969 96.9 0.48 1.0 2.2.1.1 cofactor ProteomeLM contextual percentile 0.01; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model; matched: cofactor /main_page_ml/ML0583 2026-05-30T13:09:52Z 1347 ML0129 Q9CD87 ML0129 Trans-acting enoyl reductase (EC 1.3.1.-) 418 54.674 Moderate candidate 0.1635 ProteomeLM contextual shift 0.062194977 1.0 72 1.0 1334 160 0.9908 0.9151 91.51 0.24 1.0 1.3.1.- oxidoreductase, dehydrogenase, reductase ProteomeLM contextual percentile 0.16; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: oxidoreductase, dehydrogenase, reductase /main_page_ml/ML0129 2026-05-30T13:09:52Z 1348 ML1556 Q9Z5I9 infB ML1556 MLCB596.14 Translation initiation factor IF-2 924 54.664 Moderate candidate 0.312 ProteomeLM contextual shift 0.08023187 1.0 106 1.0 2813 2 0.7016 0.5968 59.68 0.245 0.7875 translation ProteomeLM contextual percentile 0.31; strong pocket/AF2Bind evidence; matched: translation /main_page_ml/ML1556 2026-05-30T13:09:52Z 1349 ML0108 Q9CDA5 ML0108 Oxidoreductase 254 54.612 Moderate candidate 0.2575 ProteomeLM contextual shift 0.07419359 1.0 48 1.0 860 196 0.9955 0.8998 89.98 0.08 1.0 oxidoreductase, dehydrogenase, reductase ProteomeLM contextual percentile 0.26; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: oxidoreductase, dehydrogenase, reductase /main_page_ml/ML0108 2026-05-30T13:09:52Z 1350 ML1770 Q9CBN6 uspC ML1770 Sugar transport periplasmic binding protein 446 54.541 Moderate candidate 0.2945 ProteomeLM contextual shift 0.078746445 1.0 54 1.0 921 58 0.9388 0.9009 90.09 0.08 0.8625 ProteomeLM contextual percentile 0.29; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML1770 2026-05-30T13:09:52Z 1351 ML0512 Q9CCT0 alaS ML0512 Alanine--tRNA ligase (EC 6.1.1.7) (Alanyl-tRNA synthetase) (AlaRS) 908 54.523 Moderate candidate 0.0169 ProteomeLM contextual shift 0.017406609 1.0 200 1.0 2784 0 0.4445 0.8281 82.81 0.57 0.925 6.1.1.7 aminoacyl-trna, trna ligase, ligase, synthetase, cofactor ProteomeLM contextual percentile 0.02; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model; matched: aminoacyl-trna, trna ligase, ligase, synthetase, cofactor /main_page_ml/ML0512 2026-05-30T13:09:52Z 1352 ML2064 Q7APZ7 ML2064 Integral membrane protein 316 54.483 Moderate candidate 0.2701 ProteomeLM contextual shift 0.075697854 1.0 68 1.0 958 20 0.8566 0.8432 84.32 0.08 1.0 cofactor ProteomeLM contextual percentile 0.27; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: cofactor /main_page_ml/ML2064 2026-05-30T13:09:52Z 1353 ML2334 Q9CB74 ML2334 Polyketide synthase-like methyltransferase domain-containing protein 420 54.478 Moderate candidate 0.255 ProteomeLM contextual shift 0.07359711 1.0 54 1.0 1362 204 0.993 0.8952 89.52 0.08 1.0 transferase, synthase ProteomeLM contextual percentile 0.26; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: transferase, synthase /main_page_ml/ML2334 2026-05-30T13:09:52Z 1354 ML1957 Q9X798 rpoA ML1957 MLCB1222.27c DNA-directed RNA polymerase subunit alpha (RNAP subunit alpha) (EC 2.7.7.6) (RNA polymerase subunit alpha) (Transcriptase subunit alpha) 347 54.459 Moderate candidate 0.0564 ProteomeLM contextual shift 0.035656627 1.0 34 1.0 1077 72 0.9611 0.8486 84.86 0.45 1.0 2.7.7.6 rna polymerase, transcription ProteomeLM contextual percentile 0.06; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model; matched: rna polymerase, transcription /main_page_ml/ML1957 2026-05-30T13:09:52Z 1355 ML0860 O32960 ML0860 MLCB22.18 Epimerase family protein ML0860 307 54.449 Moderate candidate 0.3133 ProteomeLM contextual shift 0.08051941 1.0 46 1.0 1061 280 0.9989 0.8959 89.59 0.045 0.8625 nad ProteomeLM contextual percentile 0.31; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: nad /main_page_ml/ML0860 2026-05-30T13:09:52Z 1356 ML0276 Q7AQK6 ML0276 Rhodanese domain-containing protein 147 54.442 Moderate candidate 0.3383 ProteomeLM contextual shift 0.084483735 1.0 18 1.0 456 30 0.9539 0.8975 89.75 0.0 0.8625 ProteomeLM contextual percentile 0.34; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML0276 2026-05-30T13:09:52Z 1357 ML0258 Q7AQL0 ML0258 Exopolyphosphatase 2 (EC 3.6.1.11) 317 54.417 Moderate candidate 0.0921 ProteomeLM contextual shift 0.046302233 1.0 30 1.0 1015 128 0.9836 0.8993 89.93 0.36 1.0 3.6.1.11 ProteomeLM contextual percentile 0.09; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model /main_page_ml/ML0258 2026-05-30T13:09:52Z 1358 ML1891 P30760 rpoB ML1891 DNA-directed RNA polymerase subunit beta (RNAP subunit beta) (EC 2.7.7.6) (RNA polymerase subunit beta) (Transcriptase subunit beta) 1178 54.371 Moderate candidate 0.0664 ProteomeLM contextual shift 0.038773432 1.0 184 1.0 3594 0 0.2209 0.8797 87.97 0.45 0.925 2.7.7.6 rna polymerase, transcription ProteomeLM contextual percentile 0.07; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model; matched: rna polymerase, transcription /main_page_ml/ML1891 2026-05-30T13:09:52Z 1359 ML1903 Q9CBK3 mmaA4 ML1903 Methyl mycolic acid synthase 4 298 54.351 Moderate candidate 0.1573 ProteomeLM contextual shift 0.061210997 1.0 30 1.0 970 152 0.9993 0.8947 89.47 0.245 1.0 mycolic, transferase, synthase ProteomeLM contextual percentile 0.16; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: mycolic, transferase, synthase /main_page_ml/ML1903 2026-05-30T13:09:52Z 1360 ML0750 Q9CCK9 ML0750 LytR family transcriptional regulator 489 54.334 Moderate candidate 0.3333 ProteomeLM contextual shift 0.0832885 1.0 95 1.0 1501 28 0.9188 0.8142 81.42 0.045 0.8625 transcription ProteomeLM contextual percentile 0.33; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: transcription /main_page_ml/ML0750 2026-05-30T13:09:52Z 1361 ML0510 Q9CCT1 ML0510 AAA+ ATPase domain-containing protein 473 54.293 Moderate candidate 0.2506 ProteomeLM contextual shift 0.07299161 1.0 124 1.0 1476 114 0.9264 0.7121 71.21 0.17 1.0 dna replication, replication, enzyme ProteomeLM contextual percentile 0.25; strong pocket/AF2Bind evidence; matched: dna replication, replication, enzyme /main_page_ml/ML0510 2026-05-30T13:09:52Z 1362 ML1254 Q7AQ78 ML1254 HNH nuclease domain-containing protein 215 54.266 Moderate candidate 0.3972 ProteomeLM contextual shift 0.09223041 1.0 22 1.0 676 62 0.9269 0.6738 67.38 0.0 0.8625 ProteomeLM contextual percentile 0.40; strong pocket/AF2Bind evidence /main_page_ml/ML1254 2026-05-30T13:09:52Z 1363 ML1098 Q9CC95 ML1098 AAA+ ATPase domain-containing protein 1152 54.265 Moderate candidate 0.3164 ProteomeLM contextual shift 0.08097477 1.0 232 1.0 2344 0 0.4181 0.8716 87.16 0.08 0.7875 ProteomeLM contextual percentile 0.32; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML1098 2026-05-30T13:09:52Z 1364 ML2449 Q9CB47 ML2449 Hydrolase 271 54.14 Moderate candidate 0.2343 ProteomeLM contextual shift 0.07027356 1.0 50 1.0 834 42 0.9136 0.9338 93.38 0.08 1.0 hydrolase ProteomeLM contextual percentile 0.23; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: hydrolase /main_page_ml/ML2449 2026-05-30T13:09:52Z 1365 ML1798 Q9CBM8 ML1798 Kinase 327 54.109 Moderate candidate 0.2607 ProteomeLM contextual shift 0.074397855 1.0 110 1.0 987 12 0.726 0.8386 83.86 0.08 1.0 kinase ProteomeLM contextual percentile 0.26; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: kinase /main_page_ml/ML1798 2026-05-30T13:09:52Z 1366 ML0073 Q9CDC6 ML0073 Membrane protein 344 54.042 Moderate candidate 0.4098 ProteomeLM contextual shift 0.09325165 1.0 38 1.0 697 18 0.7097 0.6075 60.75 0.0 0.8625 ProteomeLM contextual percentile 0.41; strong pocket/AF2Bind evidence /main_page_ml/ML0073 2026-05-30T13:09:52Z 1367 ML1381 P46835 polA ML1381 DNA polymerase I (POL I) (EC 2.7.7.7) 911 53.945 Moderate candidate 0.0677 ProteomeLM contextual shift 0.03898801 1.0 133 1.0 1862 0 0.3445 0.8327 83.27 0.45 0.925 2.7.7.7 dna replication, replication ProteomeLM contextual percentile 0.07; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model; matched: dna replication, replication /main_page_ml/ML1381 2026-05-30T13:09:52Z 1368 ML0550 Q9CCQ2 ML0550 MarR-family transcriptional regulator 161 53.92 Moderate candidate 0.2769 ProteomeLM contextual shift 0.07682856 1.0 32 1.0 543 120 0.9966 0.8102 81.02 0.125 0.8625 transcription ProteomeLM contextual percentile 0.28; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: transcription /main_page_ml/ML0550 2026-05-30T13:09:52Z 1369 ML0904 Q7AQC7 ML0904 Probable membrane protein 134 53.865 Moderate candidate 0.4355 ProteomeLM contextual shift 0.095984444 1.0 14 1.0 454 104 0.9013 0.4999 49.99 0.0 0.8625 ProteomeLM contextual percentile 0.44; strong pocket/AF2Bind evidence /main_page_ml/ML0904 2026-05-30T13:09:52Z 1370 ML1313 Q7AQ71 ML1313 tRNA (adenine(58)-N(1))-methyltransferase TrmI (EC 2.1.1.220) 281 53.755 Moderate candidate 0.0056 ProteomeLM contextual shift 0.0073494287 1.0 86 1.0 853 20 0.7398 0.8958 89.58 0.48 1.0 2.1.1.220 transferase ProteomeLM contextual percentile 0.01; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model; matched: transferase /main_page_ml/ML1313 2026-05-30T13:09:52Z 1371 ML0753 Q9CCK6 rmlA2 ML0753 Sugar-phosphate nucleotidyl transferase 358 53.739 Moderate candidate 0.2212 ProteomeLM contextual shift 0.068613686 1.0 38 1.0 1092 36 0.882 0.9398 93.98 0.08 1.0 transferase ProteomeLM contextual percentile 0.22; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: transferase /main_page_ml/ML0753 2026-05-30T13:09:52Z 1372 ML0687 Q7AQG0 ML0687 Membrane protein 313 53.708 Moderate candidate 0.3214 ProteomeLM contextual shift 0.08131403 1.0 83 1.0 997 116 0.9839 0.7233 72.33 0.08 0.8625 ProteomeLM contextual percentile 0.32; strong pocket/AF2Bind evidence /main_page_ml/ML0687 2026-05-30T13:09:52Z 1373 ML2188 Q50047 phoU1 phoY phoY1 ML2188 Phosphate-specific transport system accessory protein PhoU homolog 1 (Pst system accessory protein PhoU homolog 1) 222 53.657 Moderate candidate 0.2707 ProteomeLM contextual shift 0.07569999 1.0 26 1.0 674 16 0.5939 0.8959 89.59 0.08 0.8625 ProteomeLM contextual percentile 0.27; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML2188 2026-05-30T13:09:52Z 1374 ML1927 Q9CBI4 ML1927 DUF3263 domain-containing protein 102 53.551 Moderate candidate 0.3778 ProteomeLM contextual shift 0.089803234 1.0 14 1.0 325 38 0.9343 0.7753 77.53 0.0 0.7575 ProteomeLM contextual percentile 0.38; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML1927 2026-05-30T13:09:52Z 1375 ML0114 Q9CDA0 ML0114 ABC transporter ATP-binding component 272 53.476 Moderate candidate 0.2794 ProteomeLM contextual shift 0.07725724 1.0 94 1.0 873 114 0.9628 0.847 84.7 0.08 0.8625 ProteomeLM contextual percentile 0.28; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML0114 2026-05-30T13:09:52Z 1376 ML1159 Q9CC76 ML1159 Thioredoxin domain-containing protein 301 53.421 Moderate candidate 0.3064 ProteomeLM contextual shift 0.07962181 1.0 36 1.0 612 20 0.8929 0.7472 74.72 0.08 0.8625 ProteomeLM contextual percentile 0.31; strong pocket/AF2Bind evidence /main_page_ml/ML1159 2026-05-30T13:09:52Z 1377 ML2075 Q7APZ4 ML2075 HTH merR-type domain-containing protein 251 53.391 Moderate candidate 0.2914 ProteomeLM contextual shift 0.07844016 1.0 71 1.0 554 104 0.9952 0.7068 70.68 0.125 0.8625 transcription ProteomeLM contextual percentile 0.29; strong pocket/AF2Bind evidence; matched: transcription /main_page_ml/ML2075 2026-05-30T13:09:52Z 1378 ML0378 Q49857 ML0378 B229_C1_170 Uncharacterized protein ML0378 359 53.373 Moderate candidate 0.25 ProteomeLM contextual shift 0.0727501 1.0 43 1.0 751 66 0.9453 0.8023 80.23 0.08 1.0 transferase ProteomeLM contextual percentile 0.25; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: transferase /main_page_ml/ML0378 2026-05-30T13:09:52Z 1379 ML1651 Q9CBS8 aceE ML1651 Pyruvate dehydrogenase E1 component (EC 1.2.4.1) 936 53.326 Moderate candidate 0.0081 ProteomeLM contextual shift 0.010152105 1.0 245 1.0 2868 0 0.2542 0.9191 91.91 0.48 0.925 1.2.4.1 dehydrogenase, cofactor ProteomeLM contextual percentile 0.01; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model; matched: dehydrogenase, cofactor /main_page_ml/ML1651 2026-05-30T13:09:52Z 1380 ML0065 Q7AQN8 ML0065 FAD-containing monooxygenase EthA (Prodrug activator EtaA) 494 53.247 Moderate candidate 0.1184 ProteomeLM contextual shift 0.052561097 1.0 84 1.0 1549 134 0.9633 0.9202 92.02 0.245 1.0 nad, cofactor ProteomeLM contextual percentile 0.12; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: nad, cofactor /main_page_ml/ML0065 2026-05-30T13:09:52Z 1381 ML0898 Q7AQD2 ML0898 DNA-binding protein 134 53.19 Moderate candidate 0.2487 ProteomeLM contextual shift 0.07234473 1.0 8 1.0 277 18 0.7852 0.9259 92.59 0.08 0.8625 ProteomeLM contextual percentile 0.25; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML0898 2026-05-30T13:09:52Z 1382 ML1731 Q9CBQ2 nrdF ML1731 Ribonucleoside-diphosphate reductase subunit beta (EC 1.17.4.1) (Ribonucleotide reductase small subunit) 325 53.186 Moderate candidate 0.0 ProteomeLM contextual shift 0.0013586079 1.0 62 1.0 1001 52 0.848 0.8586 85.86 0.48 1.0 1.17.4.1 reductase, cofactor ProteomeLM contextual percentile 0.00; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model; matched: reductase, cofactor /main_page_ml/ML1731 2026-05-30T13:09:52Z 1383 ML2333 Q7APW3 ML2333 Delta(24)-sterol reductase (EC 1.3.1.72) 459 53.153 Moderate candidate 0.1247 ProteomeLM contextual shift 0.053774938 1.0 52 1.0 1478 202 0.968 0.8989 89.89 0.24 1.0 1.3.1.72 reductase ProteomeLM contextual percentile 0.12; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: reductase /main_page_ml/ML2333 2026-05-30T13:09:52Z 1384 ML0117 Q9CD97 ML0117 Aminotransferase class V domain-containing protein 398 53.152 Moderate candidate 0.2494 ProteomeLM contextual shift 0.072636485 1.0 101 1.0 1199 10 0.6777 0.9424 94.24 0.0 1.0 transferase ProteomeLM contextual percentile 0.25; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: transferase /main_page_ml/ML0117 2026-05-30T13:09:52Z 1385 ML1121 Q9CC82 ML1121 Probable extracellular solute-binding dependent transport lipoprotein 557 53.125 Moderate candidate 0.2513 ProteomeLM contextual shift 0.07311188 1.0 84 1.0 1745 148 0.9773 0.9106 91.06 0.08 0.8625 ProteomeLM contextual percentile 0.25; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML1121 2026-05-30T13:09:52Z 1386 ML1847 O32995 rplE ML1847 MLCB2492.16 Large ribosomal subunit protein uL5 (50S ribosomal protein L5) 187 53.096 Moderate candidate 0.1798 ProteomeLM contextual shift 0.063881435 1.0 10 1.0 591 60 0.9249 0.8877 88.77 0.215 0.8625 translation, ribosome, ribosomal ProteomeLM contextual percentile 0.18; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: translation, ribosome, ribosomal /main_page_ml/ML1847 2026-05-30T13:09:52Z 1387 ML0095 Q9CDB5 ML0095 Integral membrane protein 302 53.082 Moderate candidate 0.2218 ProteomeLM contextual shift 0.06863958 1.0 176 1.0 994 176 0.9875 0.8719 87.19 0.08 1.0 transferase ProteomeLM contextual percentile 0.22; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: transferase /main_page_ml/ML0095 2026-05-30T13:09:52Z 1388 ML1339 Q7AQ63 ML1339 Secreted protease 525 53.065 Moderate candidate 0.2187 ProteomeLM contextual shift 0.068092115 1.0 91 1.0 1591 32 0.812 0.8812 88.12 0.08 1.0 protease ProteomeLM contextual percentile 0.22; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: protease /main_page_ml/ML1339 2026-05-30T13:09:52Z 1389 ML1224 Q9CC66 ML1224 Nudix hydrolase domain-containing protein 239 53.048 Moderate candidate 0.265 ProteomeLM contextual shift 0.075023085 1.0 40 1.0 726 18 0.7092 0.8772 87.72 0.0 1.0 hydrolase ProteomeLM contextual percentile 0.27; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: hydrolase /main_page_ml/ML1224 2026-05-30T13:09:52Z 1390 ML0857 Q7AQE8 ML0857 Membrane protein 250 52.99 Moderate candidate 0.3302 ProteomeLM contextual shift 0.08243462 1.0 20 1.0 755 10 0.6687 0.7808 78.08 0.0 0.8625 ProteomeLM contextual percentile 0.33; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML0857 2026-05-30T13:09:52Z 1391 ML1802 Q9CBM5 ML1802 Band 7 domain-containing protein 374 52.948 Moderate candidate 0.3158 ProteomeLM contextual shift 0.080871694 1.0 12 1.0 1182 0 0.3705 0.6671 66.71 0.08 0.8625 ProteomeLM contextual percentile 0.32; strong pocket/AF2Bind evidence /main_page_ml/ML1802 2026-05-30T13:09:52Z 1392 ML1316 P46509 mpa ML1316 a2126a B2126_C1_167 MLCB2533.12 Proteasome-associated ATPase (AAA ATPase forming ring-shaped complexes) (ARC) (Mycobacterial proteasome ATPase) 609 52.947 Moderate candidate 0.1165 ProteomeLM contextual shift 0.052234367 1.0 232 1.0 1868 2 0.5809 0.7143 71.43 0.405 0.8625 PATHWAY: Protein degradation; proteasomal Pup-dependent pathway. {ECO:0000255|HAMAP-Rule:MF_02112}. proteasome ProteomeLM contextual percentile 0.12; strong pocket/AF2Bind evidence; functional annotation support; matched: proteasome /main_page_ml/ML1316 2026-05-30T13:09:52Z 1393 ML0061 Q9CDD5 gltB ML0061 Ferredoxin-dependent glutamate synthase (EC 1.4.1.13) 1527 52.935 Moderate candidate 0.0401 ProteomeLM contextual shift 0.029686285 1.0 301 1.0 1547 0 0.1931 0.9282 92.82 0.445 0.835 1.4.1.13 PATHWAY: Amino-acid biosynthesis. {ECO:0000256|ARBA:ARBA00029440}. nad, synthase, cofactor ProteomeLM contextual percentile 0.04; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model; matched: nad, synthase, cofactor /main_page_ml/ML0061 2026-05-30T13:09:52Z 1394 ML1488 Q9CBX8 ML1488 Aminotransferase (EC 2.6.1.-) 367 52.909 Moderate candidate 0.1009 ProteomeLM contextual shift 0.048289355 1.0 110 1.0 1159 116 0.9442 0.9578 95.78 0.24 1.0 2.6.1.- transferase, cofactor ProteomeLM contextual percentile 0.10; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: transferase, cofactor /main_page_ml/ML1488 2026-05-30T13:09:52Z 1395 ML2580 Q7APT8 ML2580 Possible acyltransferase 384 52.752 Moderate candidate 0.2043 ProteomeLM contextual shift 0.06681731 1.0 114 1.0 794 52 0.8476 0.9003 90.03 0.08 1.0 transferase ProteomeLM contextual percentile 0.20; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: transferase /main_page_ml/ML2580 2026-05-30T13:09:52Z 1396 ML1119 Q9CC84 ML1119 Nuclease SbcCD subunit D 383 52.746 Moderate candidate 0.2431 ProteomeLM contextual shift 0.071512 1.0 48 1.0 769 6 0.5208 0.9012 90.12 0.08 0.8625 ProteomeLM contextual percentile 0.24; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML1119 2026-05-30T13:09:52Z 1397 ML0548 Q9CCQ3 priA ML0548 Probable replication restart protein PriA (Putative ATP-dependent DNA helicase PriA) 651 52.746 Moderate candidate 0.0865 ProteomeLM contextual shift 0.04493234 1.0 96 1.0 1962 18 0.8262 0.8919 89.19 0.29 1.0 dna replication, replication, cofactor ProteomeLM contextual percentile 0.09; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: dna replication, replication, cofactor /main_page_ml/ML0548 2026-05-30T13:09:52Z 1398 ML0382 Q49871 whiB3 whiB ML0382 Transcriptional regulator WhiB 102 52.717 Moderate candidate 0.1454 ProteomeLM contextual shift 0.058667712 1.0 18 1.0 372 132 0.9678 0.788 78.8 0.29 0.895 transcription, nad, reductase, cofactor ProteomeLM contextual percentile 0.15; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: transcription, nad, reductase, cofactor /main_page_ml/ML0382 2026-05-30T13:09:52Z 1399 ML0138 Q9CD79 fadD28 ML0138 Acyl-CoA synthetase 579 52.685 Moderate candidate 0.1811 ProteomeLM contextual shift 0.06390682 1.0 100 1.0 1749 24 0.7613 0.8847 88.47 0.125 1.0 cell wall, enzyme, ligase, transferase ProteomeLM contextual percentile 0.18; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: cell wall, enzyme, ligase, transferase /main_page_ml/ML0138 2026-05-30T13:09:52Z 1400 ML1652 Q7AQ34 ML1652 PucR family transcriptional regulator 414 52.657 Moderate candidate 0.2895 ProteomeLM contextual shift 0.0782408 1.0 68 1.0 1247 10 0.6574 0.8001 80.01 0.045 0.8625 transcription ProteomeLM contextual percentile 0.29; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: transcription /main_page_ml/ML1652 2026-05-30T13:09:52Z 1401 ML2072 O32915 gcvP gcvB ML2072 MLCB1788.32c Glycine dehydrogenase (decarboxylating) (EC 1.4.4.2) (Glycine cleavage system P-protein) (Glycine decarboxylase) (Glycine dehydrogenase (aminomethyl-transferring)) 952 52.655 Moderate candidate 0.0482 ProteomeLM contextual shift 0.032280162 1.0 213 1.0 2897 2 0.5645 0.9517 95.17 0.36 0.925 1.4.4.2 dehydrogenase, cofactor ProteomeLM contextual percentile 0.05; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model; matched: dehydrogenase, cofactor /main_page_ml/ML2072 2026-05-30T13:09:52Z 1402 ML1936 Q7AQ18 ychF ML1936 Ribosome-binding ATPase YchF 356 52.633 Moderate candidate 0.1284 ProteomeLM contextual shift 0.05501601 1.0 58 1.0 752 0 0.4779 0.8713 87.13 0.29 0.8625 ribosome, ribosomal ProteomeLM contextual percentile 0.13; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: ribosome, ribosomal /main_page_ml/ML1936 2026-05-30T13:09:52Z 1403 ML2536 Q9CD29 ML2536 Conserved membrane protein 552 52.587 Moderate candidate 0.2287 ProteomeLM contextual shift 0.069902025 1.0 30 1.0 1716 0 0.3934 0.7983 79.83 0.08 1.0 hydrolase ProteomeLM contextual percentile 0.23; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: hydrolase /main_page_ml/ML2536 2026-05-30T13:09:52Z 1404 ML0483 P40833 ruvB ML0483 B1177_C3_227 Holliday junction branch migration complex subunit RuvB (EC 3.6.4.-) 349 52.586 Moderate candidate 0.0025 ProteomeLM contextual shift 0.003997498 1.0 30 1.0 710 24 0.8328 0.7898 78.98 0.48 1.0 3.6.4.- ProteomeLM contextual percentile 0.00; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model /main_page_ml/ML0483 2026-05-30T13:09:52Z 1405 ML1064 Q9CCA9 ML1064 Glucosyl-3-phosphoglycerate synthase (EC 2.4.1.266) 326 52.563 Moderate candidate 0.0439 ProteomeLM contextual shift 0.031530693 1.0 92 1.0 1020 84 0.8538 0.8828 88.28 0.36 1.0 2.4.1.266 transferase, synthase, cofactor ProteomeLM contextual percentile 0.04; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model; matched: transferase, synthase, cofactor /main_page_ml/ML1064 2026-05-30T13:09:52Z 1406 ML2698 Q7APR7 ML2698 Nudix hydrolase domain-containing protein 251 52.539 Moderate candidate 0.2588 ProteomeLM contextual shift 0.074347645 1.0 33 1.0 789 72 0.9603 0.6882 68.82 0.08 1.0 hydrolase ProteomeLM contextual percentile 0.26; strong pocket/AF2Bind evidence; matched: hydrolase /main_page_ml/ML2698 2026-05-30T13:09:52Z 1407 ML0120 Q9CD94 echA1 ML0120 Enoyl-CoA hydratase 278 52.478 Moderate candidate 0.0689 ProteomeLM contextual shift 0.0397782 1.0 139 1.0 898 128 0.9651 0.9365 93.65 0.285 1.0 PATHWAY: Lipid metabolism; fatty acid beta-oxidation. {ECO:0000256|ARBA:ARBA00005005}. lipid metabolism, isomerase ProteomeLM contextual percentile 0.07; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: lipid metabolism, isomerase /main_page_ml/ML0120 2026-05-30T13:09:52Z 1408 ML1120 Q9CC83 ML1120 Endonuclease GajA/Old nuclease/RecF-like AAA domain-containing protein 873 52.464 Moderate candidate 0.3327 ProteomeLM contextual shift 0.08324834 1.0 40 1.0 1786 0 0.4225 0.7944 79.44 0.0 0.7875 ProteomeLM contextual percentile 0.33; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML1120 2026-05-30T13:09:52Z 1409 ML1839 Q7AQ20 sppA ML1839 Protease IV, signal peptide peptidase 602 52.423 Moderate candidate 0.1604 ProteomeLM contextual shift 0.061474856 1.0 108 1.0 1839 66 0.9074 0.7809 78.09 0.2 1.0 protease ProteomeLM contextual percentile 0.16; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: protease /main_page_ml/ML1839 2026-05-30T13:09:52Z 1410 ML1052 Q9CCB1 ML1052 Transcriptional regulator 421 52.41 Moderate candidate 0.2838 ProteomeLM contextual shift 0.077678464 1.0 46 1.0 1289 12 0.7093 0.7951 79.51 0.045 0.8625 transcription ProteomeLM contextual percentile 0.28; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: transcription /main_page_ml/ML1052 2026-05-30T13:09:52Z 1411 ML0854 Q9CCF8 pnp ML0854 Polyribonucleotide nucleotidyltransferase (EC 2.7.7.8) (Polynucleotide phosphorylase) (PNPase) 773 52.379 Moderate candidate 0.0013 ProteomeLM contextual shift 0.0031482377 1.0 204 1.0 1550 8 0.6723 0.8485 84.85 0.48 0.925 2.7.7.8 transferase, cofactor ProteomeLM contextual percentile 0.00; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model; matched: transferase, cofactor /main_page_ml/ML0854 2026-05-30T13:09:52Z 1412 ML1561 Q7AQ41 ML1561 DUF4439 domain-containing protein 165 52.223 Moderate candidate 0.2882 ProteomeLM contextual shift 0.07817557 1.0 36 1.0 518 6 0.6822 0.851 85.1 0.0 0.8625 ProteomeLM contextual percentile 0.29; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML1561 2026-05-30T13:09:52Z 1413 ML1632 Q9CBT2 ML1632 Possible hydrolase 511 52.223 Moderate candidate 0.1911 ProteomeLM contextual shift 0.065260954 1.0 62 1.0 1073 102 0.9709 0.8935 89.35 0.08 1.0 hydrolase ProteomeLM contextual percentile 0.19; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: hydrolase /main_page_ml/ML1632 2026-05-30T13:09:52Z 1414 ML2679 Q7APS0 ML2679 Uncharacterized protein 893 52.166 Moderate candidate 0.3102 ProteomeLM contextual shift 0.08011959 1.0 224 1.0 2739 0 0.2795 0.8435 84.35 0.0 0.7875 ProteomeLM contextual percentile 0.31; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML2679 2026-05-30T13:09:52Z 1415 ML1809 Q9CBL8 ML1809 DUF58 domain-containing protein 320 52.126 Moderate candidate 0.2964 ProteomeLM contextual shift 0.07888764 1.0 46 1.0 1038 156 0.974 0.8128 81.28 0.0 0.8625 ProteomeLM contextual percentile 0.30; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML1809 2026-05-30T13:09:52Z 1416 ML0577 P38388 secG ML0577 B1496_C3_206 Probable protein-export membrane protein SecG 77 52.115 Moderate candidate 0.3258 ProteomeLM contextual shift 0.08164193 1.0 10 1.0 244 26 0.8853 0.6536 65.36 0.08 0.7575 ProteomeLM contextual percentile 0.33; strong pocket/AF2Bind evidence /main_page_ml/ML0577 2026-05-30T13:09:52Z 1417 ML1230 Q49618 papA3 ML1230 Condensation domain-containing protein 471 52.106 Moderate candidate 0.2168 ProteomeLM contextual shift 0.0680041 1.0 131 1.0 1521 176 0.9771 0.9293 92.93 0.08 0.8625 ProteomeLM contextual percentile 0.22; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML1230 2026-05-30T13:09:52Z 1418 ML1700 O33107 gatB ML1700 MLCB637.15 Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit B (Asp/Glu-ADT subunit B) (EC 6.3.5.-) 509 52.089 Moderate candidate 0.0075 ProteomeLM contextual shift 0.009209546 1.0 101 1.0 1531 8 0.6481 0.8726 87.26 0.405 1.0 6.3.5.- translation, transferase, synthase ProteomeLM contextual percentile 0.01; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model; matched: translation, transferase, synthase /main_page_ml/ML1700 2026-05-30T13:09:52Z 1419 ML0491 Q49640 relA ML0491 B1177_C1_168 MLCB1259.09 Probable GTP pyrophosphokinase (EC 2.7.6.5) ((p)ppGpp synthase) (ATP:GTP 3'-pyrophosphotransferase) (ppGpp synthase I) 787 52.064 Moderate candidate 0.0207 ProteomeLM contextual shift 0.0187484 1.0 221 1.0 2402 2 0.5185 0.669 66.9 0.52 0.925 2.7.6.5 PATHWAY: Purine metabolism; ppGpp biosynthesis; ppGpp from GTP: step 1/2. kinase, transferase, synthase ProteomeLM contextual percentile 0.02; strong pocket/AF2Bind evidence; functional annotation support; matched: kinase, transferase, synthase /main_page_ml/ML0491 2026-05-30T13:09:52Z 1420 ML1598 O33038 rpsB ML1598 MLCB250.63 Small ribosomal subunit protein uS2 (30S ribosomal protein S2) 277 52.032 Moderate candidate 0.1736 ProteomeLM contextual shift 0.063318245 1.0 22 1.0 891 0 0.3959 0.8032 80.32 0.215 0.8625 translation, ribosome, ribosomal ProteomeLM contextual percentile 0.17; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: translation, ribosome, ribosomal /main_page_ml/ML1598 2026-05-30T13:09:52Z 1421 ML2502 Q9CB19 ML2502 Alanine aminotransferase (EC 2.6.1.2) (Alanine transaminase) (Transaminase A) 437 52.002 Moderate candidate 0.0138 ProteomeLM contextual shift 0.015572653 1.0 68 1.0 905 62 0.8928 0.932 93.2 0.36 1.0 2.6.1.2 transferase, cofactor ProteomeLM contextual percentile 0.01; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model; matched: transferase, cofactor /main_page_ml/ML2502 2026-05-30T13:09:52Z 1422 ML1372 Q49884 der engA ML1372 MLCB1351.01 u0247e GTPase Der (GTP-binding protein EngA) 461 51.958 Moderate candidate 0.1779 ProteomeLM contextual shift 0.06379197 1.0 80 1.0 1391 10 0.6988 0.7204 72.04 0.245 0.8625 ribosome ProteomeLM contextual percentile 0.18; strong pocket/AF2Bind evidence; matched: ribosome /main_page_ml/ML1372 2026-05-30T13:09:52Z 1423 ML0015 Q7AQP6 pabA ML0015 p-aminobenzoate synthase glutamine amidotransferase 232 51.925 Moderate candidate 0.1805 ProteomeLM contextual shift 0.0638972 1.0 14 1.0 333 14 0.8551 0.901 90.1 0.08 1.0 transferase, synthase ProteomeLM contextual percentile 0.18; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: transferase, synthase /main_page_ml/ML0015 2026-05-30T13:09:52Z 1424 ML1051 Q7AQA2 xclC ML1051 Acyl-CoA synthase 476 51.877 Moderate candidate 0.1773 ProteomeLM contextual shift 0.0635508 1.0 82 1.0 1493 130 0.9772 0.9071 90.71 0.08 1.0 enzyme, ligase, synthase ProteomeLM contextual percentile 0.18; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: enzyme, ligase, synthase /main_page_ml/ML1051 2026-05-30T13:09:52Z 1425 ML2329 O69520 recR ML2329 MLCB2407.21 Recombination protein RecR 203 51.753 Moderate candidate 0.2199 ProteomeLM contextual shift 0.068433896 1.0 74 1.0 661 104 0.9724 0.883 88.3 0.08 0.8625 ProteomeLM contextual percentile 0.22; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML2329 2026-05-30T13:09:52Z 1426 ML2305 Q9CB88 ML2305 Probable anion transporter protein 341 51.707 Moderate candidate 0.2206 ProteomeLM contextual shift 0.06849899 1.0 84 1.0 1035 24 0.6925 0.8762 87.62 0.08 0.8625 ProteomeLM contextual percentile 0.22; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML2305 2026-05-30T13:09:52Z 1427 ML0099 Q9CDB3 ML0099 Cutinase 336 51.674 Moderate candidate 0.188 ProteomeLM contextual shift 0.06454778 1.0 34 1.0 1038 60 0.9784 0.8495 84.95 0.08 1.0 hydrolase ProteomeLM contextual percentile 0.19; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: hydrolase /main_page_ml/ML0099 2026-05-30T13:09:52Z 1428 ML1582 Q9CBU4 rip1 ML1582 Zinc metalloprotease Rip1 (EC 3.4.24.-) (S2P endopeptidase) (Site-2 protease Rip1) (S2P protease Rip1) (Site-2-type intramembrane protease) 404 51.61 Moderate candidate 0.0251 ProteomeLM contextual shift 0.020287605 1.0 80 1.0 1311 198 0.9541 0.8533 85.33 0.36 1.0 3.4.24.- protease, cofactor ProteomeLM contextual percentile 0.03; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model; matched: protease, cofactor /main_page_ml/ML1582 2026-05-30T13:09:52Z 1429 ML0001 P46388 dnaA ML0001 Chromosomal replication initiator protein DnaA 502 51.508 Moderate candidate 0.166 ProteomeLM contextual shift 0.06251474 1.0 66 1.0 1589 12 0.6412 0.6272 62.72 0.29 0.8625 dna replication, replication ProteomeLM contextual percentile 0.17; strong pocket/AF2Bind evidence; matched: dna replication, replication /main_page_ml/ML0001 2026-05-30T13:09:52Z 1430 ML2157 Q9CBE0 ML2157 DNA 3'-5' helicase (EC 5.6.2.4) 549 51.495 Moderate candidate 0.0107 ProteomeLM contextual shift 0.012602195 1.0 80 1.0 1653 12 0.7773 0.8922 89.22 0.36 1.0 5.6.2.4 hydrolase ProteomeLM contextual percentile 0.01; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model; matched: hydrolase /main_page_ml/ML2157 2026-05-30T13:09:52Z 1431 ML1465 Q9CBZ4 obg ML1465 GTPase Obg (EC 3.6.5.-) (GTP-binding protein Obg) 479 51.418 Moderate candidate 0.0263 ProteomeLM contextual shift 0.021375118 1.0 54 1.0 1478 2 0.5238 0.7397 73.97 0.405 1.0 3.6.5.- ribosome, cofactor ProteomeLM contextual percentile 0.03; strong pocket/AF2Bind evidence; functional annotation support; matched: ribosome, cofactor /main_page_ml/ML1465 2026-05-30T13:09:52Z 1432 ML1369 Q7AQ59 ML1369 Segregation and condensation protein B 231 51.392 Moderate candidate 0.2519 ProteomeLM contextual shift 0.07314328 1.0 36 1.0 728 70 0.8535 0.6451 64.51 0.125 0.8625 cell division ProteomeLM contextual percentile 0.25; strong pocket/AF2Bind evidence; matched: cell division /main_page_ml/ML1369 2026-05-30T13:09:52Z 1433 ML1861 O32983 rplW ML1861 MLCB2492.04 Large ribosomal subunit protein uL23 (50S ribosomal protein L23) 100 51.308 Moderate candidate 0.1723 ProteomeLM contextual shift 0.06322116 1.0 10 1.0 327 54 0.8976 0.8402 84.02 0.215 0.7575 translation, ribosome, ribosomal ProteomeLM contextual percentile 0.17; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: translation, ribosome, ribosomal /main_page_ml/ML1861 2026-05-30T13:09:52Z 1434 ML1540 Q7AQ48 ML1540 ESX secretion-associated protein EspG 300 51.301 Moderate candidate 0.2093 ProteomeLM contextual shift 0.06728272 1.0 84 1.0 947 94 0.893 0.8752 87.52 0.08 0.8625 ProteomeLM contextual percentile 0.21; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML1540 2026-05-30T13:09:52Z 1435 ML1940 Q9X783 xseA ML1940 MLCB1222.08 Exodeoxyribonuclease 7 large subunit (EC 3.1.11.6) (Exodeoxyribonuclease VII large subunit) (Exonuclease VII large subunit) 428 51.232 Moderate candidate 0.0338 ProteomeLM contextual shift 0.024662528 1.0 24 1.0 1289 10 0.6484 0.7848 78.48 0.36 1.0 3.1.11.6 ProteomeLM contextual percentile 0.03; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model /main_page_ml/ML1940 2026-05-30T13:09:52Z 1436 ML1862 O32982 rplD ML1862 MLCB2492.03 Large ribosomal subunit protein uL4 (50S ribosomal protein L4) 230 51.221 Moderate candidate 0.1729 ProteomeLM contextual shift 0.06329228 1.0 10 1.0 726 72 0.9298 0.7244 72.44 0.215 0.8625 translation, ribosome, ribosomal ProteomeLM contextual percentile 0.17; strong pocket/AF2Bind evidence; matched: translation, ribosome, ribosomal /main_page_ml/ML1862 2026-05-30T13:09:52Z 1437 ML0791 Q9CCI4 ML0791 Ribosome small subunit-dependent GTPase A 327 51.184 Moderate candidate 0.1999 ProteomeLM contextual shift 0.06632056 1.0 42 1.0 1004 46 0.8434 0.8063 80.63 0.125 0.8625 ribosome ProteomeLM contextual percentile 0.20; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: ribosome /main_page_ml/ML0791 2026-05-30T13:09:52Z 1438 ML2259 Q9CBB7 ML2259 Possible membrane protein 96 51.091 Moderate candidate 0.3622 ProteomeLM contextual shift 0.087768316 1.0 14 1.0 205 26 0.9786 0.5841 58.41 0.0 0.7575 ProteomeLM contextual percentile 0.36; strong pocket/AF2Bind evidence /main_page_ml/ML2259 2026-05-30T13:09:52Z 1439 ML2620 O06081 mmpL3 ML2620 MLCL622.18c Probable trehalose monomycolate exporter MmpL3 (TMM exporter MmpL3) (MmpL3 transporter) (Mycobacterial membrane protein large 3) 955 51.084 Moderate candidate 0.1241 ProteomeLM contextual shift 0.05376106 1.0 163 1.0 2925 0 0.4463 0.7167 71.67 0.335 0.7875 cell division, cell wall, mycolic ProteomeLM contextual percentile 0.12; strong pocket/AF2Bind evidence; matched: cell division, cell wall, mycolic /main_page_ml/ML2620 2026-05-30T13:09:52Z 1440 ML1863 P30762 rplC ML1863 MLCB2492.02 Large ribosomal subunit protein uL3 (50S ribosomal protein L3) 217 50.99 Moderate candidate 0.1692 ProteomeLM contextual shift 0.06294574 1.0 16 1.0 677 46 0.8355 0.7144 71.44 0.215 0.8625 translation, ribosome, ribosomal ProteomeLM contextual percentile 0.17; strong pocket/AF2Bind evidence; matched: translation, ribosome, ribosomal /main_page_ml/ML1863 2026-05-30T13:09:52Z 1441 ML0997 Q9CCC0 hflX ML0997 GTPase HflX (GTP-binding protein HflX) 488 50.965 Moderate candidate 0.1228 ProteomeLM contextual shift 0.053707696 1.0 82 1.0 1475 22 0.9302 0.6766 67.66 0.245 1.0 ribosome, cofactor ProteomeLM contextual percentile 0.12; strong pocket/AF2Bind evidence; matched: ribosome, cofactor /main_page_ml/ML0997 2026-05-30T13:09:52Z 1442 ML0625 Q49762 dnaJ2 ML0625 B1937_F2_56 Chaperone protein DnaJ 2 378 50.935 Moderate candidate 0.0733 ProteomeLM contextual shift 0.040977303 1.0 26 1.0 761 10 0.8212 0.7569 75.69 0.29 1.0 dna replication, replication, cofactor ProteomeLM contextual percentile 0.07; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: dna replication, replication, cofactor /main_page_ml/ML0625 2026-05-30T13:09:52Z 1443 ML2276 Q9CBA6 ML2276 FAD-linked oxidoreductase 408 50.923 Moderate candidate 0.119 ProteomeLM contextual shift 0.052589122 1.0 68 1.0 1336 224 0.9984 0.9256 92.56 0.125 1.0 nad, oxidoreductase, reductase ProteomeLM contextual percentile 0.12; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: nad, oxidoreductase, reductase /main_page_ml/ML2276 2026-05-30T13:09:52Z 1444 ML0047 Q9CDD9 ML0047 Membrane protein 512 50.876 Moderate candidate 0.2462 ProteomeLM contextual shift 0.07191556 1.0 109 1.0 1577 2 0.5053 0.7033 70.33 0.08 0.8625 ProteomeLM contextual percentile 0.25; strong pocket/AF2Bind evidence /main_page_ml/ML0047 2026-05-30T13:09:52Z 1445 ML1132 P45835 rho ML1132 Transcription termination factor Rho (EC 3.6.4.-) (ATP-dependent helicase Rho) 610 50.865 Moderate candidate 0.047 ProteomeLM contextual shift 0.032038763 1.0 214 1.0 1873 6 0.6475 0.612 61.2 0.405 1.0 3.6.4.- transcription, hydrolase ProteomeLM contextual percentile 0.05; strong pocket/AF2Bind evidence; functional annotation support; matched: transcription, hydrolase /main_page_ml/ML1132 2026-05-30T13:09:52Z 1446 ML1489 Q9CBX7 fdxA ML1489 Ferredoxin 108 50.766 Moderate candidate 0.1642 ProteomeLM contextual shift 0.06236078 1.0 20 1.0 327 6 0.5968 0.9471 94.71 0.08 0.895 cofactor ProteomeLM contextual percentile 0.16; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: cofactor /main_page_ml/ML1489 2026-05-30T13:09:52Z 1447 ML0873 Q9CCF3 ML0873 Carbohydrate kinase 324 50.724 Moderate candidate 0.1316 ProteomeLM contextual shift 0.05612941 1.0 48 1.0 699 102 0.9929 0.9519 95.19 0.08 1.0 kinase ProteomeLM contextual percentile 0.13; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: kinase /main_page_ml/ML0873 2026-05-30T13:09:52Z 1448 ML2700 Q9CCX9 ML2700 Possible conserved membrane protein 1206 50.691 Moderate candidate 0.2813 ProteomeLM contextual shift 0.07746085 1.0 213 1.0 1207 2 0.5816 0.6369 63.69 0.125 0.6975 peptidoglycan ProteomeLM contextual percentile 0.28; strong pocket/AF2Bind evidence; matched: peptidoglycan /main_page_ml/ML2700 2026-05-30T13:09:52Z 1449 ML1555 Q9Z5I8 rbfA ML1555 MLCB596.15 Ribosome-binding factor A 164 50.665 Moderate candidate 0.1855 ProteomeLM contextual shift 0.064329036 1.0 22 1.0 503 22 0.9367 0.7149 71.49 0.17 0.8625 ribosome, ribosomal ProteomeLM contextual percentile 0.19; strong pocket/AF2Bind evidence; matched: ribosome, ribosomal /main_page_ml/ML1555 2026-05-30T13:09:52Z 1450 ML2073 Q7APZ6 ML2073 HTH merR-type domain-containing protein 231 50.629 Moderate candidate 0.2406 ProteomeLM contextual shift 0.07107577 1.0 12 1.0 704 22 0.8474 0.6083 60.83 0.125 0.8625 transcription ProteomeLM contextual percentile 0.24; strong pocket/AF2Bind evidence; matched: transcription /main_page_ml/ML2073 2026-05-30T13:09:52Z 1451 ML1036 P46838 ag45 ML1036 46 kDa membrane protein 429 50.607 Moderate candidate 0.1898 ProteomeLM contextual shift 0.06490266 1.0 119 1.0 1305 36 0.7483 0.8738 87.38 0.08 0.8625 ProteomeLM contextual percentile 0.19; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML1036 2026-05-30T13:09:52Z 1452 ML2649 Q9CCZ2 ML2649 NodB homology domain-containing protein 271 50.569 Moderate candidate 0.1554 ProteomeLM contextual shift 0.06019331 1.0 28 1.0 824 22 0.8507 0.8531 85.31 0.08 1.0 hydrolase ProteomeLM contextual percentile 0.16; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: hydrolase /main_page_ml/ML2649 2026-05-30T13:09:52Z 1453 ML1907 Q9CBJ9 secE ML1907 Protein translocase subunit SecE 146 50.53 Moderate candidate 0.3177 ProteomeLM contextual shift 0.08105307 1.0 16 1.0 509 102 0.9403 0.4186 41.86 0.08 0.8625 ProteomeLM contextual percentile 0.32; strong pocket/AF2Bind evidence /main_page_ml/ML1907 2026-05-30T13:09:52Z 1454 ML1367 Q9CC29 ML1367 Possible regulatory protein 287 50.515 Moderate candidate 0.2237 ProteomeLM contextual shift 0.06942288 1.0 52 1.0 614 0 0.425 0.9061 90.61 0.0 0.8625 ProteomeLM contextual percentile 0.22; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML1367 2026-05-30T13:09:52Z 1455 ML0561 Q9CCP2 ML0561 Membrane protein 156 50.504 Moderate candidate 0.2368 ProteomeLM contextual shift 0.07057617 1.0 12 1.0 510 4 0.5903 0.8589 85.89 0.0 0.8625 ProteomeLM contextual percentile 0.24; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML0561 2026-05-30T13:09:52Z 1456 ML1859 O32985 rpsS ML1859 MLCB2492.06 Small ribosomal subunit protein uS19 (30S ribosomal protein S19) 93 50.498 Moderate candidate 0.161 ProteomeLM contextual shift 0.061616328 1.0 8 1.0 291 24 0.7163 0.7987 79.87 0.215 0.7575 translation, ribosome, ribosomal ProteomeLM contextual percentile 0.16; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: translation, ribosome, ribosomal /main_page_ml/ML1859 2026-05-30T13:09:52Z 1457 ML2597 Q9CD06 ML2597 Conserved membrane protein 184 50.432 Moderate candidate 0.2118 ProteomeLM contextual shift 0.067521505 1.0 18 1.0 568 32 0.837 0.7794 77.94 0.08 0.8625 ProteomeLM contextual percentile 0.21; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML2597 2026-05-30T13:09:52Z 1458 ML1962 P0A5H7 infA ML1962 Translation initiation factor IF-1 73 50.381 Moderate candidate 0.1617 ProteomeLM contextual shift 0.06172176 1.0 8 1.0 369 30 0.7863 0.8749 87.49 0.17 0.7575 translation, ribosome ProteomeLM contextual percentile 0.16; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: translation, ribosome /main_page_ml/ML1962 2026-05-30T13:09:52Z 1459 ML1497 Q9CBX3 ML1497 Possible secreted protein 617 50.325 Moderate candidate 0.1917 ProteomeLM contextual shift 0.0652643 1.0 122 1.0 1274 0 0.4567 0.839 83.9 0.08 0.8625 ProteomeLM contextual percentile 0.19; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML1497 2026-05-30T13:09:52Z 1460 ML0764 Q9CCJ6 ML0764 TobH protein 365 50.252 Moderate candidate 0.1848 ProteomeLM contextual shift 0.06427274 1.0 50 1.0 1136 2 0.5683 0.8557 85.57 0.08 0.8625 ProteomeLM contextual percentile 0.18; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML0764 2026-05-30T13:09:52Z 1461 ML2528 Q9CD36 ML2528 Protease 475 50.209 Moderate candidate 0.0852 ProteomeLM contextual shift 0.044542566 1.0 61 1.0 1439 28 0.8326 0.8227 82.27 0.2 1.0 protease ProteomeLM contextual percentile 0.09; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: protease /main_page_ml/ML2528 2026-05-30T13:09:52Z 1462 ML2156 Q9CBE1 ML2156 Possible DNA-binding protein 753 50.191 Moderate candidate 0.208 ProteomeLM contextual shift 0.0672008 1.0 100 1.0 2319 0 0.3418 0.8436 84.36 0.08 0.7875 ProteomeLM contextual percentile 0.21; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML2156 2026-05-30T13:09:52Z 1463 ML2143 O33057 ML2143 MLCB57.28c Uncharacterized protein ML2143 579 50.125 Moderate candidate 0.2356 ProteomeLM contextual shift 0.070538975 1.0 90 1.0 1763 52 0.8146 0.6654 66.54 0.08 0.8625 ProteomeLM contextual percentile 0.24; strong pocket/AF2Bind evidence /main_page_ml/ML2143 2026-05-30T13:09:52Z 1464 ML1333 Q9ZBD8 helY ML1333 MLCB2533.29 Probable helicase HelY (EC 3.6.4.-) 920 50.094 Moderate candidate 0.0201 ProteomeLM contextual shift 0.018628348 1.0 140 1.0 2820 0 0.4841 0.7942 79.42 0.36 0.925 3.6.4.- hydrolase ProteomeLM contextual percentile 0.02; strong pocket/AF2Bind evidence; functional annotation support; high-confidence Boltz2 model; matched: hydrolase /main_page_ml/ML1333 2026-05-30T13:09:52Z 1465 ML2518 Q9CD39 ML2518 Transmembrane protein 130 50.076 Moderate candidate 0.3114 ProteomeLM contextual shift 0.08021735 1.0 14 1.0 427 74 0.9428 0.5552 55.52 0.0 0.8625 ProteomeLM contextual percentile 0.31; strong pocket/AF2Bind evidence /main_page_ml/ML2518 2026-05-30T13:09:52Z 1466 ML1391 Q9CC25 ML1391 Metallo-beta-lactamase domain-containing protein 232 50.061 Moderate candidate 0.1992 ProteomeLM contextual shift 0.06627842 1.0 24 1.0 716 40 0.8528 0.9462 94.62 0.0 0.8625 ProteomeLM contextual percentile 0.20; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML1391 2026-05-30T13:09:52Z 1467 ML1782 Q9CBN4 ML1782 Beta-lactamase-related domain-containing protein 273 50.06 Moderate candidate 0.1924 ProteomeLM contextual shift 0.06540067 1.0 34 1.0 568 44 0.973 0.9702 97.02 0.0 0.8625 ProteomeLM contextual percentile 0.19; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML1782 2026-05-30T13:09:52Z 1468 ML0763 Q9CCJ7 pmmA ML0763 Phosphomannomutase 468 50.031 Moderate candidate 0.114 ProteomeLM contextual shift 0.051403992 1.0 46 1.0 965 58 0.9172 0.944 94.4 0.08 1.0 transferase, cofactor ProteomeLM contextual percentile 0.11; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: transferase, cofactor /main_page_ml/ML0763 2026-05-30T13:09:52Z 1469 ML0849 Q7AQF0 ML0849 Cobalt transport protein 283 49.938 Exploratory 0.2306 ProteomeLM contextual shift 0.07006933 1.0 38 1.0 580 28 0.9354 0.6643 66.43 0.08 0.8625 ProteomeLM contextual percentile 0.23; strong pocket/AF2Bind evidence /main_page_ml/ML0849 2026-05-30T13:09:52Z 1470 ML2582 Q9CD17 ML2582 Conserved membrane protein 600 49.908 Exploratory 0.2105 ProteomeLM contextual shift 0.067426436 1.0 115 1.0 1808 16 0.6946 0.8915 89.15 0.0 0.8625 ProteomeLM contextual percentile 0.21; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML2582 2026-05-30T13:09:52Z 1471 ML1123 Q9CC80 ML1123 Oligopeptide transport system permease protein OppC 299 49.89 Exploratory 0.1792 ProteomeLM contextual shift 0.06380375 1.0 68 1.0 902 10 0.6474 0.8393 83.93 0.08 0.8625 ProteomeLM contextual percentile 0.18; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML1123 2026-05-30T13:09:52Z 1472 ML0184 Q9CD65 rimJ ML0184 Possible acetyltransferase 214 49.865 Exploratory 0.1109 ProteomeLM contextual shift 0.05015704 1.0 32 1.0 757 230 0.9945 0.9383 93.83 0.08 1.0 transferase ProteomeLM contextual percentile 0.11; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: transferase /main_page_ml/ML0184 2026-05-30T13:09:52Z 1473 ML1959 Q9X7A0 rpsK ML1959 MLCB1222.29c Small ribosomal subunit protein uS11 (30S ribosomal protein S11) 138 49.86 Exploratory 0.1147 ProteomeLM contextual shift 0.051457606 1.0 26 1.0 454 80 0.9555 0.7922 79.22 0.215 0.8625 translation, ribosome, ribosomal ProteomeLM contextual percentile 0.11; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: translation, ribosome, ribosomal /main_page_ml/ML1959 2026-05-30T13:09:52Z 1474 ML1912 Q9CBJ4 ML1912 Glyoxylase II 238 49.8 Exploratory 0.1071 ProteomeLM contextual shift 0.04962788 1.0 34 1.0 754 80 0.9801 0.945 94.5 0.08 1.0 hydrolase, cofactor ProteomeLM contextual percentile 0.11; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: hydrolase, cofactor /main_page_ml/ML1912 2026-05-30T13:09:52Z 1475 ML2147 Q7APY2 cspB ML2147 Probable cold shock protein 136 49.789 Exploratory 0.1861 ProteomeLM contextual shift 0.064353906 1.0 12 1.0 432 8 0.6532 0.805 80.5 0.08 0.8625 ProteomeLM contextual percentile 0.19; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML2147 2026-05-30T13:09:52Z 1476 ML0817 Q9CCG8 moeZ ML0817 Probable adenylyltransferase/sulfurtransferase MoeZ 395 49.771 Exploratory 0.1278 ProteomeLM contextual shift 0.054804627 1.0 114 1.0 1275 180 0.9769 0.8697 86.97 0.08 1.0 enzyme, transferase ProteomeLM contextual percentile 0.13; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: enzyme, transferase /main_page_ml/ML0817 2026-05-30T13:09:52Z 1477 ML0508 Q9CCT2 ML0508 Transglutaminase-like domain-containing protein 313 49.723 Exploratory 0.2099 ProteomeLM contextual shift 0.06737003 1.0 80 1.0 661 70 0.9003 0.8751 87.51 0.0 0.8625 ProteomeLM contextual percentile 0.21; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML0508 2026-05-30T13:09:52Z 1478 ML2411 Q7APV0 ML2411 Possible cytochrome C-type biogenesis protein 262 49.684 Exploratory 0.2807 ProteomeLM contextual shift 0.07742629 1.0 62 1.0 601 154 0.9982 0.6235 62.35 0.0 0.8625 ProteomeLM contextual percentile 0.28; strong pocket/AF2Bind evidence /main_page_ml/ML2411 2026-05-30T13:09:52Z 1479 ML1781 Q9CBN5 ML1781 DUF3145 domain-containing protein 170 49.679 Exploratory 0.2162 ProteomeLM contextual shift 0.067878634 1.0 16 1.0 541 62 0.7988 0.8488 84.88 0.0 0.8625 ProteomeLM contextual percentile 0.22; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML1781 2026-05-30T13:09:52Z 1480 ML0816 Q9CCG9 ML0816 Peptidase metallopeptidase domain-containing protein 341 49.671 Exploratory 0.2174 ProteomeLM contextual shift 0.06800674 1.0 30 1.0 1051 16 0.7333 0.6836 68.36 0.08 0.8625 ProteomeLM contextual percentile 0.22; strong pocket/AF2Bind evidence /main_page_ml/ML0816 2026-05-30T13:09:52Z 1481 ML2400 Q9CB64 ML2400 Probable transmembrane protein 285 49.654 Exploratory 0.2325 ProteomeLM contextual shift 0.07024053 1.0 43 1.0 928 146 0.9869 0.7893 78.93 0.0 0.8625 ProteomeLM contextual percentile 0.23; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML2400 2026-05-30T13:09:52Z 1482 ML1361 Q9CC30 ML1361 Conserved membrane protein 393 49.637 Exploratory 0.1497 ProteomeLM contextual shift 0.05922116 1.0 68 1.0 1195 32 0.895 0.7796 77.96 0.08 1.0 kinase ProteomeLM contextual percentile 0.15; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: kinase /main_page_ml/ML1361 2026-05-30T13:09:52Z 1483 ML2442 P54139 ML2442 B2168_C3_245 u2168e Uncharacterized protein ML2442 184 49.624 Exploratory 0.218 ProteomeLM contextual shift 0.06806098 1.0 20 1.0 595 86 0.9853 0.8368 83.68 0.0 0.8625 ProteomeLM contextual percentile 0.22; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML2442 2026-05-30T13:09:52Z 1484 ML0887 Q9CCE6 ML0887 Acyl-CoA synthetase 600 49.624 Exploratory 0.1096 ProteomeLM contextual shift 0.04998296 1.0 112 1.0 1834 68 0.7441 0.9186 91.86 0.08 1.0 enzyme, ligase, synthetase ProteomeLM contextual percentile 0.11; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: enzyme, ligase, synthetase /main_page_ml/ML0887 2026-05-30T13:09:52Z 1485 ML2710 Q50205 yidC ML2710 Membrane protein insertase YidC (Foldase YidC) (Membrane integrase YidC) (Membrane protein YidC) 380 49.589 Exploratory 0.2262 ProteomeLM contextual shift 0.06970769 1.0 108 1.0 1166 12 0.6716 0.6447 64.47 0.08 0.8625 ProteomeLM contextual percentile 0.23; strong pocket/AF2Bind evidence /main_page_ml/ML2710 2026-05-30T13:09:52Z 1486 ML1538 Q9CBV3 ML1538 Possible protease 567 49.568 Exploratory 0.0946 ProteomeLM contextual shift 0.046882346 1.0 84 1.0 1709 16 0.6702 0.7257 72.57 0.2 1.0 protease ProteomeLM contextual percentile 0.09; strong pocket/AF2Bind evidence; matched: protease /main_page_ml/ML1538 2026-05-30T13:09:52Z 1487 ML1629 Q9CBT5 smc ML1629 MLCB250.01 Chromosome partition protein Smc 1203 49.563 Exploratory 0.1209 ProteomeLM contextual shift 0.05288985 1.0 75 1.0 1223 0 0.2573 0.7555 75.55 0.29 0.6975 dna replication, replication ProteomeLM contextual percentile 0.12; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: dna replication, replication /main_page_ml/ML1629 2026-05-30T13:09:52Z 1488 ML2493 Q9CB24 hspR ML2493 Heat shock regulator 132 49.556 Exploratory 0.1761 ProteomeLM contextual shift 0.063372105 1.0 30 1.0 405 18 0.7775 0.7269 72.69 0.125 0.8625 transcription ProteomeLM contextual percentile 0.18; strong pocket/AF2Bind evidence; matched: transcription /main_page_ml/ML2493 2026-05-30T13:09:52Z 1489 ML2704 Q9CCX8 ML2704 Hydrolase 406 49.549 Exploratory 0.1003 ProteomeLM contextual shift 0.04819425 1.0 52 1.0 1246 18 0.8951 0.764 76.4 0.17 1.0 peptidoglycan, mur, hydrolase ProteomeLM contextual percentile 0.10; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: peptidoglycan, mur, hydrolase /main_page_ml/ML2704 2026-05-30T13:09:52Z 1490 ML2590 Q9CD13 mce1B ML2590 Secreted protein 346 49.502 Exploratory 0.2625 ProteomeLM contextual shift 0.07464492 1.0 44 1.0 1123 130 0.9751 0.5089 50.89 0.08 0.8625 ProteomeLM contextual percentile 0.26; strong pocket/AF2Bind evidence /main_page_ml/ML2590 2026-05-30T13:09:52Z 1491 ML1844 O32998 rplF ML1844 MLCB2492.19 Large ribosomal subunit protein uL6 (50S ribosomal protein L6) 179 49.468 Exploratory 0.0708 ProteomeLM contextual shift 0.040079273 1.0 8 1.0 547 20 0.7544 0.9065 90.65 0.215 0.8625 translation, ribosome, ribosomal ProteomeLM contextual percentile 0.07; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: translation, ribosome, ribosomal /main_page_ml/ML1844 2026-05-30T13:09:52Z 1492 ML2427 P54878 ML2427 B2168_C1_175 Uncharacterized protein ML2427 367 49.464 Exploratory 0.1673 ProteomeLM contextual shift 0.062681586 1.0 54 1.0 1223 226 0.996 0.7009 70.09 0.08 1.0 transferase ProteomeLM contextual percentile 0.17; strong pocket/AF2Bind evidence; matched: transferase /main_page_ml/ML2427 2026-05-30T13:09:52Z 1493 ML0872 Q9CCF4 ML0872 Membrane protein 171 49.377 Exploratory 0.2224 ProteomeLM contextual shift 0.06870579 1.0 24 1.0 541 56 0.9463 0.7967 79.67 0.0 0.8625 ProteomeLM contextual percentile 0.22; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML0872 2026-05-30T13:09:52Z 1494 ML0631 Q49768 era ML0631 B1937_F3_102 GTPase Era 300 49.33 Exploratory 0.0307 ProteomeLM contextual shift 0.023489697 1.0 34 1.0 616 24 0.7288 0.883 88.3 0.29 0.8625 ribosomal, cell wall ProteomeLM contextual percentile 0.03; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: ribosomal, cell wall /main_page_ml/ML0631 2026-05-30T13:09:52Z 1495 ML1380 Q7AQ58 ML1380 Uncharacterized protein 187 49.306 Exploratory 0.203 ProteomeLM contextual shift 0.0667007 1.0 12 1.0 585 8 0.6485 0.8576 85.76 0.0 0.8625 ProteomeLM contextual percentile 0.20; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML1380 2026-05-30T13:09:52Z 1496 ML1305 Q7AQ73 ansP2 ML1305 Probable L-asparagine permease 505 49.268 Exploratory 0.1711 ProteomeLM contextual shift 0.063105166 1.0 86 1.0 1536 42 0.807 0.8056 80.56 0.08 0.8625 ProteomeLM contextual percentile 0.17; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML1305 2026-05-30T13:09:52Z 1497 ML2494 Q02605 dnaJ1 ML2494 Chaperone protein DnaJ 1 388 49.22 Exploratory 0.0357 ProteomeLM contextual shift 0.025245845 1.0 18 1.0 1186 4 0.5752 0.717 71.7 0.29 1.0 dna replication, replication, cofactor ProteomeLM contextual percentile 0.04; strong pocket/AF2Bind evidence; matched: dna replication, replication, cofactor /main_page_ml/ML2494 2026-05-30T13:09:52Z 1498 ML0917 Q9CCE4 ftsZ ML0917 Cell division protein FtsZ 379 49.09 Exploratory 0.0395 ProteomeLM contextual shift 0.028811567 1.0 66 1.0 1160 46 0.8068 0.7384 73.84 0.335 0.8625 cell division, ftsz, fts ProteomeLM contextual percentile 0.04; strong pocket/AF2Bind evidence; matched: cell division, ftsz, fts /main_page_ml/ML0917 2026-05-30T13:09:52Z 1499 ML1657 Q7AQ32 ML1657 Acetyl/propionyl CoA carboxylase [beta] subunit 473 49.022 Exploratory 0.1259 ProteomeLM contextual shift 0.054181926 1.0 132 1.0 953 14 0.6525 0.9389 93.89 0.08 0.8625 ProteomeLM contextual percentile 0.13; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML1657 2026-05-30T13:09:52Z 1500 ML2247 Q7APX1 cpsA ML2247 Transcriptional regulator, LytR family protein 516 49.011 Exploratory 0.2143 ProteomeLM contextual shift 0.06775418 1.0 105 1.0 1055 46 0.9386 0.6986 69.86 0.045 0.8625 transcription ProteomeLM contextual percentile 0.21; strong pocket/AF2Bind evidence; matched: transcription /main_page_ml/ML2247 2026-05-30T13:09:52Z 1501 ML0115 Q9CD99 bpa ML0115 Bacterial proteasome activator 174 48.979 Exploratory 0.193 ProteomeLM contextual shift 0.06545543 1.0 74 1.0 561 78 0.958 0.61 61.0 0.125 0.8625 proteasome ProteomeLM contextual percentile 0.19; strong pocket/AF2Bind evidence; matched: proteasome /main_page_ml/ML0115 2026-05-30T13:09:52Z 1502 ML0004 Q9CDF4 ML0004 MLB1770.04 UPF0232 protein ML0004 189 48.95 Exploratory 0.2732 ProteomeLM contextual shift 0.07626597 1.0 20 1.0 611 48 0.9054 0.5763 57.63 0.0 0.8625 ProteomeLM contextual percentile 0.27; strong pocket/AF2Bind evidence /main_page_ml/ML0004 2026-05-30T13:09:52Z 1503 ML0907 Q7AQC6 ML0907 Conserved membrane protein 377 48.929 Exploratory 0.3515 ProteomeLM contextual shift 0.08614641 1.0 22 1.0 1164 66 0.8772 0.3001 30.01 0.0 0.8625 ProteomeLM contextual percentile 0.35; strong pocket/AF2Bind evidence /main_page_ml/ML0907 2026-05-30T13:09:52Z 1504 ML0489 Q49646 ML0489 B1177_C2_197 MLCB1259.07 Uncharacterized lipoprotein ML0489 555 48.923 Exploratory 0.1266 ProteomeLM contextual shift 0.054391127 1.0 94 1.0 1668 6 0.5887 0.9268 92.68 0.08 0.8625 ProteomeLM contextual percentile 0.13; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML0489 2026-05-30T13:09:52Z 1505 ML2501 Q9CB20 ML2501 Probable iron-sulphur-binding reductase 880 48.863 Exploratory 0.1416 ProteomeLM contextual shift 0.058012888 1.0 146 1.0 1765 10 0.5662 0.8057 80.57 0.08 0.925 oxidoreductase, reductase ProteomeLM contextual percentile 0.14; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: oxidoreductase, reductase /main_page_ml/ML2501 2026-05-30T13:09:52Z 1506 ML0762 Q9CCJ8 ML0762 DUF3499 domain-containing protein 165 48.79 Exploratory 0.2845 ProteomeLM contextual shift 0.07776482 1.0 32 1.0 531 72 0.8766 0.5209 52.09 0.0 0.8625 ProteomeLM contextual percentile 0.28; strong pocket/AF2Bind evidence /main_page_ml/ML0762 2026-05-30T13:09:52Z 1507 ML1304 Q7AQ74 ansP1 ML1304 Probable L-asparagine permease 498 48.781 Exploratory 0.1535 ProteomeLM contextual shift 0.059933238 1.0 90 1.0 1503 18 0.7489 0.8183 81.83 0.08 0.8625 ProteomeLM contextual percentile 0.15; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML1304 2026-05-30T13:09:52Z 1508 ML1590 O33046 frr ML1590 MLCB250.76 Ribosome-recycling factor (RRF) (Ribosome-releasing factor) 185 48.741 Exploratory 0.0539 ProteomeLM contextual shift 0.034486085 1.0 8 1.0 600 10 0.6529 0.893 89.3 0.215 0.8625 translation, ribosome, ribosomal ProteomeLM contextual percentile 0.05; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: translation, ribosome, ribosomal /main_page_ml/ML1590 2026-05-30T13:09:52Z 1509 ML0003 P46391 recF ML0003 DNA replication and repair protein RecF 385 48.67 Exploratory 0.0063 ProteomeLM contextual shift 0.008204671 1.0 52 1.0 1215 0 0.4669 0.9026 90.26 0.29 0.8625 dna replication, replication ProteomeLM contextual percentile 0.01; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: dna replication, replication /main_page_ml/ML0003 2026-05-30T13:09:52Z 1510 ML1950 Q7AQ13 ML1950 Carbohydrate degrading enzyme 291 48.669 Exploratory 0.094 ProteomeLM contextual shift 0.04669348 1.0 40 1.0 910 74 0.965 0.878 87.8 0.08 1.0 enzyme, hydrolase ProteomeLM contextual percentile 0.09; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: enzyme, hydrolase /main_page_ml/ML1950 2026-05-30T13:09:52Z 1511 ML1332 P54078 tatC mttB ML1332 B2126_C1_183 MLCB2533.28 u2126a Sec-independent protein translocase protein TatC 310 48.6 Exploratory 0.1748 ProteomeLM contextual shift 0.063350126 1.0 139 1.0 877 38 0.7895 0.7256 72.56 0.08 0.8625 ProteomeLM contextual percentile 0.17; strong pocket/AF2Bind evidence /main_page_ml/ML1332 2026-05-30T13:09:52Z 1512 ML1346 Q9CC34 ML1346 Possible long-chain acyl-CoA synthase 1002 48.568 Exploratory 0.1385 ProteomeLM contextual shift 0.057254728 1.0 138 1.0 3009 6 0.6301 0.7872 78.72 0.08 0.925 enzyme, ligase, synthase ProteomeLM contextual percentile 0.14; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: enzyme, ligase, synthase /main_page_ml/ML1346 2026-05-30T13:09:52Z 1513 ML0112 Q9CDA2 ML0112 ABC transporter component 276 48.53 Exploratory 0.1404 ProteomeLM contextual shift 0.05771427 1.0 88 1.0 555 6 0.5985 0.8392 83.92 0.08 0.8625 ProteomeLM contextual percentile 0.14; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML0112 2026-05-30T13:09:52Z 1514 ML2142 Q7APY4 ML2142 DUF3027 domain-containing protein 269 48.319 Exploratory 0.2249 ProteomeLM contextual shift 0.069460005 1.0 22 1.0 842 70 0.9419 0.6821 68.21 0.0 0.8625 ProteomeLM contextual percentile 0.22; strong pocket/AF2Bind evidence /main_page_ml/ML2142 2026-05-30T13:09:52Z 1515 ML0041 Q7AQP4 ML0041 Probable secreted protease 446 48.317 Exploratory 0.0194 ProteomeLM contextual shift 0.017810382 1.0 48 1.0 916 48 0.9687 0.8638 86.38 0.2 1.0 protease ProteomeLM contextual percentile 0.02; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: protease /main_page_ml/ML0041 2026-05-30T13:09:52Z 1516 ML0320 Q9CCW7 ML0320 Transcription factor 165 48.308 Exploratory 0.104 ProteomeLM contextual shift 0.048956946 1.0 24 1.0 513 36 0.7606 0.8543 85.43 0.125 0.8625 transcription ProteomeLM contextual percentile 0.10; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: transcription /main_page_ml/ML0320 2026-05-30T13:09:52Z 1517 ML1382 P46836 rpsA ML1382 Small ribosomal subunit protein bS1 (30S ribosomal protein S1) 481 48.26 Exploratory 0.0915 ProteomeLM contextual shift 0.046288747 1.0 30 1.0 1486 6 0.6289 0.7134 71.34 0.215 0.8625 translation, ribosome, ribosomal ProteomeLM contextual percentile 0.09; strong pocket/AF2Bind evidence; matched: translation, ribosome, ribosomal /main_page_ml/ML1382 2026-05-30T13:09:52Z 1518 ML0365 P40828 rpsI ML0365 B229_C2_191 Small ribosomal subunit protein uS9 (30S ribosomal protein S9) 153 48.232 Exploratory 0.0858 ProteomeLM contextual shift 0.04473153 1.0 14 1.0 492 66 0.9315 0.7302 73.02 0.215 0.8625 translation, ribosome, ribosomal ProteomeLM contextual percentile 0.09; strong pocket/AF2Bind evidence; matched: translation, ribosome, ribosomal /main_page_ml/ML0365 2026-05-30T13:09:52Z 1519 ML1468 Q9CBZ1 ML1468 Ribonuclease E (EC 3.1.26.12) 924 48.153 Exploratory 0.0426 ProteomeLM contextual shift 0.030983232 1.0 164 1.0 1879 22 0.73 0.5212 52.12 0.36 0.925 3.1.26.12 cofactor ProteomeLM contextual percentile 0.04; strong pocket/AF2Bind evidence; functional annotation support; matched: cofactor /main_page_ml/ML1468 2026-05-30T13:09:52Z 1520 ML1895 P30763 rplL ML1895 Large ribosomal subunit protein bL12 (50S ribosomal protein L7/L12) 130 48.123 Exploratory 0.0827 ProteomeLM contextual shift 0.04375179 1.0 12 1.0 287 14 0.717 0.7303 73.03 0.215 0.8625 translation, ribosome, ribosomal ProteomeLM contextual percentile 0.08; strong pocket/AF2Bind evidence; matched: translation, ribosome, ribosomal /main_page_ml/ML1895 2026-05-30T13:09:52Z 1521 ML2425 P54879 ML2425 B2168_F2_80 UPF0336 protein ML2425 166 48.111 Exploratory 0.1817 ProteomeLM contextual shift 0.063907884 1.0 14 1.0 526 56 0.9798 0.8126 81.26 0.0 0.8625 ProteomeLM contextual percentile 0.18; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML2425 2026-05-30T13:09:52Z 1522 ML0256 Q9CD41 ML0256 Membrane protein 227 48.104 Exploratory 0.3039 ProteomeLM contextual shift 0.07942409 1.0 18 1.0 746 90 0.9911 0.3843 38.43 0.0 0.8625 ProteomeLM contextual percentile 0.30; strong pocket/AF2Bind evidence /main_page_ml/ML0256 2026-05-30T13:09:52Z 1523 ML0455 Q9CCU0 ML0455 HIT domain-containing protein 206 48.078 Exploratory 0.1015 ProteomeLM contextual shift 0.048292875 1.0 74 1.0 657 78 0.9507 0.69 69.0 0.2 0.8625 ProteomeLM contextual percentile 0.10; strong pocket/AF2Bind evidence /main_page_ml/ML0455 2026-05-30T13:09:52Z 1524 ML1087 Q9CCA2 ML1087 Probable ABC-transport protein, inner membrane component 304 47.992 Exploratory 0.1466 ProteomeLM contextual shift 0.059013728 1.0 83 1.0 923 22 0.921 0.7635 76.35 0.08 0.8625 ProteomeLM contextual percentile 0.15; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML1087 2026-05-30T13:09:52Z 1525 ML1477 Q9CBY6 clpX ML1477 ATP-dependent Clp protease ATP-binding subunit ClpX 426 47.984 Exploratory 0.0038 ProteomeLM contextual shift 0.0059590787 1.0 46 1.0 1309 62 0.9229 0.7953 79.53 0.245 1.0 cell division, protease ProteomeLM contextual percentile 0.00; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: cell division, protease /main_page_ml/ML1477 2026-05-30T13:09:52Z 1526 ML0563 Q9CCP0 ML0563 Nucleotide-binding protein ML0563 298 47.98 Exploratory 0.0752 ProteomeLM contextual shift 0.04175321 1.0 48 1.0 603 14 0.7271 0.7723 77.23 0.2 0.8625 ProteomeLM contextual percentile 0.08; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML0563 2026-05-30T13:09:52Z 1527 ML0880 Q9CCE7 qcrA ML0880 Cytochrome bc1 complex Rieske iron-sulfur subunit (Cytochrome bc1 reductase complex subunit QcrA) (Rieske iron-sulfur protein) 394 47.801 Exploratory 0.1378 ProteomeLM contextual shift 0.057242706 1.0 54 1.0 1234 104 0.9442 0.6376 63.76 0.08 1.0 oxidoreductase, reductase ProteomeLM contextual percentile 0.14; strong pocket/AF2Bind evidence; matched: oxidoreductase, reductase /main_page_ml/ML0880 2026-05-30T13:09:52Z 1528 ML2135 Q7APY7 ML2135 Possible transmembrane protein 341 47.728 Exploratory 0.0633 ProteomeLM contextual shift 0.038270846 1.0 56 1.0 1092 138 0.9923 0.8913 89.13 0.08 1.0 oxidoreductase, reductase ProteomeLM contextual percentile 0.06; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: oxidoreductase, reductase /main_page_ml/ML2135 2026-05-30T13:09:52Z 1529 ML1365 Q49890 xerD ML1365 MLC1351.07c u0247d Tyrosine recombinase XerD 316 47.715 Exploratory 0.0464 ProteomeLM contextual shift 0.031817917 1.0 44 1.0 668 72 0.95 0.7567 75.67 0.245 0.8625 cell division ProteomeLM contextual percentile 0.05; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: cell division /main_page_ml/ML1365 2026-05-30T13:09:52Z 1530 ML2592 Q9CD11 mce1D ML2592 Secreted protein 531 47.565 Exploratory 0.2086 ProteomeLM contextual shift 0.06725589 1.0 64 1.0 1628 30 0.8959 0.5037 50.37 0.08 0.8625 ProteomeLM contextual percentile 0.21; strong pocket/AF2Bind evidence /main_page_ml/ML2592 2026-05-30T13:09:52Z 1531 ML0336 Q9CCW0 ML0336 ABC-tranporter ATP-binding protein 275 47.484 Exploratory 0.1053 ProteomeLM contextual shift 0.049216952 1.0 42 1.0 834 18 0.7227 0.8574 85.74 0.08 0.8625 ProteomeLM contextual percentile 0.11; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML0336 2026-05-30T13:09:52Z 1532 ML0235 P24428 clpC ML0235 Probable ATP-dependent Clp protease ATP-binding subunit 848 47.469 Exploratory 0.0652 ProteomeLM contextual shift 0.038693912 1.0 90 1.0 2604 0 0.2938 0.6938 69.38 0.2 0.925 protease ProteomeLM contextual percentile 0.07; strong pocket/AF2Bind evidence; matched: protease /main_page_ml/ML0235 2026-05-30T13:09:52Z 1533 ML1040 Q7AQA4 ML1040 HRDC domain-containing protein 429 47.406 Exploratory 0.0971 ProteomeLM contextual shift 0.047274105 1.0 40 1.0 1301 28 0.7457 0.8782 87.82 0.08 0.8625 ProteomeLM contextual percentile 0.10; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML1040 2026-05-30T13:09:52Z 1534 ML1330 P54075 pafC ML1330 B2126_C2_220 MLCB2533.26 Protein PafC 324 47.17 Exploratory 0.2055 ProteomeLM contextual shift 0.06688992 1.0 46 1.0 1026 108 0.8905 0.6352 63.52 0.0 0.8625 ProteomeLM contextual percentile 0.21; strong pocket/AF2Bind evidence /main_page_ml/ML1330 2026-05-30T13:09:52Z 1535 ML1103 Q9CC92 ML1103 Possible oxidoreductase subunit 453 47.096 Exploratory 0.0301 ProteomeLM contextual shift 0.023447655 1.0 80 1.0 1466 214 0.9753 0.9443 94.43 0.08 1.0 transferase, oxidoreductase, reductase ProteomeLM contextual percentile 0.03; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: transferase, oxidoreductase, reductase /main_page_ml/ML1103 2026-05-30T13:09:52Z 1536 ML1644 Q7AQ36 ML1644 SURF1-like protein 270 47.04 Exploratory 0.1028 ProteomeLM contextual shift 0.04881525 1.0 18 1.0 561 2 0.5439 0.8218 82.18 0.08 0.8625 ProteomeLM contextual percentile 0.10; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML1644 2026-05-30T13:09:52Z 1537 ML0661 Q7AQG8 fadE24 ML0661 Acyl-CoA dehydrogenase 465 46.927 Exploratory 0.067 ProteomeLM contextual shift 0.03878432 1.0 100 1.0 1454 78 0.9887 0.798 79.8 0.08 1.0 dehydrogenase, cofactor ProteomeLM contextual percentile 0.07; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: dehydrogenase, cofactor /main_page_ml/ML0661 2026-05-30T13:09:52Z 1538 ML1080 P53382 mrp ML1080 Iron-sulfur cluster carrier protein 383 46.881 Exploratory 0.0257 ProteomeLM contextual shift 0.020556554 1.0 66 1.0 1165 32 0.787 0.8357 83.57 0.2 0.8625 ProteomeLM contextual percentile 0.03; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML1080 2026-05-30T13:09:52Z 1539 ML1860 O32984 rplB ML1860 MLCB2492.05 Large ribosomal subunit protein uL2 (50S ribosomal protein L2) 280 46.866 Exploratory 0.0238 ProteomeLM contextual shift 0.01978936 1.0 42 1.0 862 44 0.8823 0.6733 67.33 0.215 1.0 translation, ribosome, ribosomal, transferase ProteomeLM contextual percentile 0.02; strong pocket/AF2Bind evidence; matched: translation, ribosome, ribosomal, transferase /main_page_ml/ML1860 2026-05-30T13:09:52Z 1540 ML1880 P30766 rpsL ML1880 Small ribosomal subunit protein uS12 (30S ribosomal protein S12) 124 46.785 Exploratory 0.0288 ProteomeLM contextual shift 0.021918176 1.0 10 1.0 418 92 0.9725 0.7851 78.51 0.215 0.8625 translation, ribosome, ribosomal ProteomeLM contextual percentile 0.03; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: translation, ribosome, ribosomal /main_page_ml/ML1880 2026-05-30T13:09:52Z 1541 ML1360 Q49896 recN ML1360 MLC1351.12c DNA repair protein RecN (Recombination protein N) 587 46.779 Exploratory 0.0244 ProteomeLM contextual shift 0.019891888 1.0 50 1.0 1787 12 0.6525 0.8298 82.98 0.2 0.8625 ProteomeLM contextual percentile 0.02; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML1360 2026-05-30T13:09:52Z 1542 ML0595 Q7AQH5 ML0595 ABC transporter ATP-binding protein 260 46.656 Exploratory 0.0777 ProteomeLM contextual shift 0.042275365 1.0 34 1.0 845 130 0.9672 0.8711 87.11 0.08 0.8625 ProteomeLM contextual percentile 0.08; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML0595 2026-05-30T13:09:52Z 1543 ML0908 Q7AQC5 pbpB ML0908 Penicillin-binding protein 2 675 46.651 Exploratory 0.062 ProteomeLM contextual shift 0.03789671 1.0 77 1.0 2085 0 0.3968 0.8355 83.55 0.125 0.8625 cell wall ProteomeLM contextual percentile 0.06; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: cell wall /main_page_ml/ML0908 2026-05-30T13:09:52Z 1544 ML1144 P45824 atpG ML1144 ATP synthase gamma chain (ATP synthase F1 sector gamma subunit) (F-ATPase gamma subunit) 298 46.644 Exploratory 0.0125 ProteomeLM contextual shift 0.014964412 1.0 44 1.0 897 6 0.7302 0.8705 87.05 0.125 1.0 atp synthase, synthase ProteomeLM contextual percentile 0.01; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: atp synthase, synthase /main_page_ml/ML1144 2026-05-30T13:09:52Z 1545 ML0892 Q7AQD7 ML0892 Possible acyltransferase 244 46.556 Exploratory 0.0533 ProteomeLM contextual shift 0.03437144 1.0 34 1.0 788 112 0.9888 0.8092 80.92 0.08 1.0 transferase ProteomeLM contextual percentile 0.05; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: transferase /main_page_ml/ML0892 2026-05-30T13:09:52Z 1546 ML0396 Q57240 ML0396; ML2692 B1620_F3_113 L222-ORF2 Uncharacterized protein ML0396/ML2692 369 46.453 Exploratory 0.0294 ProteomeLM contextual shift 0.023184119 1.0 162 1.0 1171 128 0.9406 0.8823 88.23 0.08 1.0 synthase ProteomeLM contextual percentile 0.03; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: synthase /main_page_ml/ML0396 2026-05-30T13:09:52Z 1547 ML0594 Q49682 ML0594 B1496_C1_154 MLCL536.27c u1496a Iron-sulfur cluster assembly SufBD family protein ML0594 392 46.447 Exploratory 0.0602 ProteomeLM contextual shift 0.037290197 1.0 74 1.0 1198 4 0.5485 0.9117 91.17 0.08 0.8625 ProteomeLM contextual percentile 0.06; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML0594 2026-05-30T13:09:52Z 1548 ML0627 Q49751 ML0627 B1937_F1_20 PhoH-like protein 349 46.429 Exploratory 0.0163 ProteomeLM contextual shift 0.017164491 1.0 124 1.0 1077 60 0.8869 0.8234 82.34 0.2 0.8625 ProteomeLM contextual percentile 0.02; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML0627 2026-05-30T13:09:52Z 1549 ML1231 Q49619 mmpL10 tp1 ML1231 B1170_C1_181 Probable transport protein MmpL10 1008 46.411 Exploratory 0.0846 ProteomeLM contextual shift 0.044238694 1.0 138 1.0 2971 4 0.5251 0.8076 80.76 0.125 0.7875 cell division ProteomeLM contextual percentile 0.08; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: cell division /main_page_ml/ML1231 2026-05-30T13:09:52Z 1550 ML0562 Q9CCP1 uvrC ML0562 UvrABC system protein C (Protein UvrC) (Excinuclease ABC subunit C) 647 46.303 Exploratory 0.0977 ProteomeLM contextual shift 0.047376435 1.0 88 1.0 1983 4 0.5088 0.7657 76.57 0.08 0.8625 ProteomeLM contextual percentile 0.10; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML0562 2026-05-30T13:09:52Z 1551 ML1624 O33011 ML1624 MLCB250.18c Uncharacterized protein ML1624 596 46.303 Exploratory 0.052 ProteomeLM contextual shift 0.034258295 1.0 96 1.0 1830 4 0.7198 0.7883 78.83 0.08 1.0 hydrolase ProteomeLM contextual percentile 0.05; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: hydrolase /main_page_ml/ML1624 2026-05-30T13:09:52Z 1552 ML0624 Q9CCN2 hrcA ML0624 B1937_F1_18/B1937_F3_95 Heat-inducible transcription repressor HrcA 343 46.177 Exploratory 0.0476 ProteomeLM contextual shift 0.032155707 1.0 96 1.0 1055 12 0.751 0.8386 83.86 0.125 0.8625 transcription ProteomeLM contextual percentile 0.05; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: transcription /main_page_ml/ML0624 2026-05-30T13:09:52Z 1553 ML0831 Q9CCG3 ML0831 Deoxyguanosinetriphosphate triphosphohydrolase-like protein 429 46.168 Exploratory 0.0113 ProteomeLM contextual shift 0.012638103 1.0 208 1.0 1315 56 0.7758 0.9174 91.74 0.08 1.0 hydrolase ProteomeLM contextual percentile 0.01; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: hydrolase /main_page_ml/ML0831 2026-05-30T13:09:52Z 1554 ML0644 Q9CCM6 ML0644 MLCB1779.46 UPF0182 protein ML0644 983 46.15 Exploratory 0.0871 ProteomeLM contextual shift 0.045138475 1.0 192 1.0 3009 0 0.3224 0.8626 86.26 0.08 0.7875 ProteomeLM contextual percentile 0.09; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML0644 2026-05-30T13:09:52Z 1555 ML2409 Q7APV1 ML2409 Possible cytochrome C biogenesis protein 327 46.071 Exploratory 0.0902 ProteomeLM contextual shift 0.045843985 1.0 51 1.0 1010 18 0.7382 0.7688 76.88 0.08 0.8625 ProteomeLM contextual percentile 0.09; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML2409 2026-05-30T13:09:52Z 1556 ML1387 P57991 uvrB ML1387 UvrABC system protein B (Protein UvrB) (Excinuclease ABC subunit B) 698 46.041 Exploratory 0.0031 ProteomeLM contextual shift 0.005252897 1.0 112 1.0 2109 30 0.948 0.8307 83.07 0.2 0.8625 ProteomeLM contextual percentile 0.00; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML1387 2026-05-30T13:09:52Z 1557 ML1439 Q9CC05 rbpA ML1439 RNA polymerase-binding protein RbpA 111 46.037 Exploratory 0.0702 ProteomeLM contextual shift 0.039972488 1.0 12 1.0 361 56 0.9339 0.6231 62.31 0.17 0.895 rna polymerase, transcription, enzyme ProteomeLM contextual percentile 0.07; strong pocket/AF2Bind evidence; matched: rna polymerase, transcription, enzyme /main_page_ml/ML1439 2026-05-30T13:09:52Z 1558 ML1661 Q9CBS6 ML1661 MLCB1243.13 Uncharacterized protein ML1661 245 45.914 Exploratory 0.1648 ProteomeLM contextual shift 0.06238411 1.0 8 1.0 782 2 0.5588 0.6522 65.22 0.0 0.8625 ProteomeLM contextual percentile 0.16; strong pocket/AF2Bind evidence /main_page_ml/ML1661 2026-05-30T13:09:52Z 1559 ML1013 Q9CCB5 ideR ML1013 Iron-dependent repressor IdeR 230 45.818 Exploratory 0.0219 ProteomeLM contextual shift 0.018938987 1.0 64 1.0 694 8 0.6744 0.8925 89.25 0.125 0.8625 transcription ProteomeLM contextual percentile 0.02; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: transcription /main_page_ml/ML1013 2026-05-30T13:09:52Z 1560 ML2302 Q9CB91 ML2302 CRP-like cAMP-activated global transcriptional regulator (cAMP receptor protein) (cAMP regulatory protein) 224 45.793 Exploratory 0.0226 ProteomeLM contextual shift 0.019308837 1.0 112 1.0 722 100 0.9444 0.8878 88.78 0.125 0.8625 transcription ProteomeLM contextual percentile 0.02; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: transcription /main_page_ml/ML2302 2026-05-30T13:09:52Z 1561 ML0920 Q9CCE1 sepF ML0920 Cell division protein SepF 210 45.768 Exploratory 0.084 ProteomeLM contextual shift 0.044075206 1.0 26 1.0 663 66 0.8607 0.4905 49.05 0.215 0.8625 cell division, ftsz, fts ProteomeLM contextual percentile 0.08; strong pocket/AF2Bind evidence; matched: cell division, ftsz, fts /main_page_ml/ML0920 2026-05-30T13:09:52Z 1562 ML1908 Q9CBJ8 ML1908 UPF0336 protein ML1908 166 45.678 Exploratory 0.0608 ProteomeLM contextual shift 0.037358087 1.0 28 1.0 546 96 0.9787 0.8326 83.26 0.08 0.8625 ProteomeLM contextual percentile 0.06; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML1908 2026-05-30T13:09:52Z 1563 ML2298 Q9CB95 ML2298 Membrane-associated serine protease 401 45.678 Exploratory 0.0269 ProteomeLM contextual shift 0.021822533 1.0 74 1.0 1207 8 0.5978 0.8135 81.35 0.08 1.0 protease ProteomeLM contextual percentile 0.03; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: protease /main_page_ml/ML2298 2026-05-30T13:09:52Z 1564 ML0642 Q49746 ML0642 Hydrolase 479 45.663 Exploratory 0.1078 ProteomeLM contextual shift 0.04981862 1.0 62 1.0 1449 24 0.8571 0.6891 68.91 0.0 1.0 hydrolase ProteomeLM contextual percentile 0.11; strong pocket/AF2Bind evidence; matched: hydrolase /main_page_ml/ML0642 2026-05-30T13:09:52Z 1565 ML0068 Q9CDD0 ML0068 Uncharacterized protein 238 45.581 Exploratory 0.1591 ProteomeLM contextual shift 0.061376497 1.0 10 1.0 484 16 0.7076 0.6385 63.85 0.0 0.8625 ProteomeLM contextual percentile 0.16; strong pocket/AF2Bind evidence /main_page_ml/ML0068 2026-05-30T13:09:52Z 1566 ML0978 Q7AQC1 ML0978 Acetyltransferase 180 45.461 Exploratory 0.0069 ProteomeLM contextual shift 0.008974014 1.0 52 1.0 611 142 0.9807 0.862 86.2 0.08 1.0 transferase ProteomeLM contextual percentile 0.01; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: transferase /main_page_ml/ML0978 2026-05-30T13:09:52Z 1567 ML2428 Q9CB57 ML2428 Possible glucose epimerase/dehydratase 364 45.441 Exploratory 0.1021 ProteomeLM contextual shift 0.048767347 1.0 46 1.0 1267 112 0.979 0.8391 83.91 0.045 0.7575 ribosomal ProteomeLM contextual percentile 0.10; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: ribosomal /main_page_ml/ML2428 2026-05-30T13:09:52Z 1568 ML2697 Q9CCY1 pcnA ML2697 PcnA 486 45.44 Exploratory 0.0044 ProteomeLM contextual shift 0.006102518 1.0 72 1.0 1466 16 0.8791 0.8686 86.86 0.08 1.0 transferase, cofactor ProteomeLM contextual percentile 0.00; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: transferase, cofactor /main_page_ml/ML2697 2026-05-30T13:09:52Z 1569 ML0556 Q9CCP7 ML0556 Probable triacylglyceride transporter ML0556 (MFS-type drug efflux transporter P55) 509 45.427 Exploratory 0.0658 ProteomeLM contextual shift 0.038764067 1.0 88 1.0 1549 44 0.8045 0.7899 78.99 0.08 0.8625 ProteomeLM contextual percentile 0.07; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML0556 2026-05-30T13:09:52Z 1570 ML1390 Q9CC26 ML1390 UspA domain-containing protein 147 45.393 Exploratory 0.1303 ProteomeLM contextual shift 0.055360377 1.0 64 1.0 334 80 0.9922 0.7207 72.07 0.0 0.8625 ProteomeLM contextual percentile 0.13; strong pocket/AF2Bind evidence /main_page_ml/ML1390 2026-05-30T13:09:52Z 1571 ML2699 Q9CCY0 ML2699 Secreted protein 797 45.372 Exploratory 0.1203 ProteomeLM contextual shift 0.0528608 1.0 92 1.0 1634 0 0.4004 0.8286 82.86 0.0 0.7875 ProteomeLM contextual percentile 0.12; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML2699 2026-05-30T13:09:52Z 1572 ML2496 P19993 dnaK ML2496 Chaperone protein DnaK (70 kDa antigen) (HSP70) (Heat shock 70 kDa protein) (Heat shock protein 70) 620 45.279 Exploratory 0.0551 ProteomeLM contextual shift 0.035116844 1.0 68 1.0 1264 8 0.7085 0.8124 81.24 0.08 0.8625 ProteomeLM contextual percentile 0.06; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML2496 2026-05-30T13:09:52Z 1573 ML2709 Q7APR5 ML2709 R3H domain-containing protein 193 45.249 Exploratory 0.0614 ProteomeLM contextual shift 0.03764364 1.0 58 1.0 602 46 0.9177 0.7875 78.75 0.08 0.8625 ProteomeLM contextual percentile 0.06; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML2709 2026-05-30T13:09:52Z 1574 ML1041 Q7AQA3 ML1041 DUF3000 domain-containing protein 196 45.193 Exploratory 0.0996 ProteomeLM contextual shift 0.047490526 1.0 12 1.0 605 34 0.8256 0.8082 80.82 0.0 0.8625 ProteomeLM contextual percentile 0.10; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML1041 2026-05-30T13:09:52Z 1575 ML2306 Q9CB87 ML2306 Probable anion transporter protein 381 45.174 Exploratory 0.0363 ProteomeLM contextual shift 0.02574044 1.0 47 1.0 780 36 0.9372 0.8677 86.77 0.08 0.8625 ProteomeLM contextual percentile 0.04; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML2306 2026-05-30T13:09:52Z 1576 ML2084 Q7APZ0 ML2084 Probable multidrug resistance pump 638 45.167 Exploratory 0.0376 ProteomeLM contextual shift 0.027957385 1.0 197 1.0 1955 2 0.5847 0.8626 86.26 0.08 0.8625 ProteomeLM contextual percentile 0.04; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML2084 2026-05-30T13:09:52Z 1577 ML0605 Q49755 ML0605 B1937_F1_4 MLCL536.05c u1937b Uncharacterized protein ML0605 561 45.135 Exploratory 0.0959 ProteomeLM contextual shift 0.047142204 1.0 86 1.0 1726 6 0.8385 0.8155 81.55 0.0 0.8625 ProteomeLM contextual percentile 0.10; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML0605 2026-05-30T13:09:52Z 1578 ML1399 Q9CC18 ML1399 Guanylate cyclase domain-containing protein 324 44.975 Exploratory 0.0965 ProteomeLM contextual shift 0.047212403 1.0 58 1.0 990 36 0.8565 0.6373 63.73 0.08 0.8625 ProteomeLM contextual percentile 0.10; strong pocket/AF2Bind evidence /main_page_ml/ML1399 2026-05-30T13:09:52Z 1579 ML0761 Q9CCJ9 ML0761 Exonuclease 167 44.861 Exploratory 0.1159 ProteomeLM contextual shift 0.051527284 1.0 18 1.0 522 42 0.9176 0.7179 71.79 0.0 0.8625 ProteomeLM contextual percentile 0.12; strong pocket/AF2Bind evidence /main_page_ml/ML0761 2026-05-30T13:09:52Z 1580 ML0565 Q9CCN8 whiA ML0565 Probable cell division protein WhiA 327 44.772 Exploratory 0.0006 ProteomeLM contextual shift 0.0027261057 1.0 16 1.0 979 8 0.6683 0.8625 86.25 0.125 0.8625 cell division ProteomeLM contextual percentile 0.00; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: cell division /main_page_ml/ML0565 2026-05-30T13:09:52Z 1581 ML1009 Q7AQB4 ML1009 Proteasome protein 326 44.732 Exploratory 0.057 ProteomeLM contextual shift 0.03595661 1.0 178 1.0 1038 120 0.9564 0.8211 82.11 0.045 0.8625 proteasome ProteomeLM contextual percentile 0.06; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: proteasome /main_page_ml/ML1009 2026-05-30T13:09:52Z 1582 ML1808 Q9CBL9 ML1808 UPF0353 protein ML1808 335 44.713 Exploratory 0.0345 ProteomeLM contextual shift 0.025095418 1.0 38 1.0 1046 2 0.5118 0.8282 82.82 0.08 0.8625 ProteomeLM contextual percentile 0.03; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML1808 2026-05-30T13:09:52Z 1583 ML0871 Q9CCF5 ML0871 Core domain-containing protein 118 44.659 Exploratory 0.0645 ProteomeLM contextual shift 0.03838606 1.0 10 1.0 359 10 0.7104 0.8225 82.25 0.08 0.7575 ProteomeLM contextual percentile 0.06; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML0871 2026-05-30T13:09:52Z 1584 ML1558 Q9Z5J1 nusA ML1558 MLCB596.12 Transcription termination/antitermination protein NusA 347 44.655 Exploratory 0.005 ProteomeLM contextual shift 0.006883688 1.0 20 1.0 1064 6 0.6577 0.8355 83.55 0.125 0.8625 transcription ProteomeLM contextual percentile 0.01; strong pocket/AF2Bind evidence; high-confidence Boltz2 model; matched: transcription /main_page_ml/ML1558 2026-05-30T13:09:52Z 1585 ML1362 Q49894 mctB ML1362 MLC1351.10c u0247f Copper transporter MctB 317 44.578 Exploratory 0.037 ProteomeLM contextual shift 0.026074339 1.0 50 1.0 992 2 0.6045 0.8059 80.59 0.08 0.8625 ProteomeLM contextual percentile 0.04; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML1362 2026-05-30T13:09:52Z 1586 ML0159 Q7AQN5 ML0159 Membrane protein 430 44.517 Exploratory 0.099 ProteomeLM contextual shift 0.04744909 1.0 84 1.0 1313 46 0.8867 0.7427 74.27 0.0 0.8625 ProteomeLM contextual percentile 0.10; strong pocket/AF2Bind evidence /main_page_ml/ML0159 2026-05-30T13:09:52Z 1587 ML2410 Q9CB62 ML2410 Conserved membrane protein 542 44.516 Exploratory 0.0451 ProteomeLM contextual shift 0.03158046 1.0 72 1.0 1633 14 0.7118 0.7712 77.12 0.08 0.8625 ProteomeLM contextual percentile 0.05; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML2410 2026-05-30T13:09:52Z 1588 ML2604 Q9CD02 ML2604 Uncharacterized protein 249 44.271 Exploratory 0.0833 ProteomeLM contextual shift 0.043862738 1.0 38 1.0 771 8 0.6094 0.7729 77.29 0.0 0.8625 ProteomeLM contextual percentile 0.08; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML2604 2026-05-30T13:09:52Z 1589 ML2070 Q9CBE8 ML2070 VWFA domain-containing protein 733 44.248 Exploratory 0.1115 ProteomeLM contextual shift 0.05017532 1.0 106 1.0 2259 0 0.3445 0.672 67.2 0.0 0.8625 ProteomeLM contextual percentile 0.11; strong pocket/AF2Bind evidence /main_page_ml/ML2070 2026-05-30T13:09:52Z 1590 ML0488 P38386 secF ML0488 B1177_C3_239 MLCB1259.06 Protein translocase subunit SecF 471 44.11 Exploratory 0.0771 ProteomeLM contextual shift 0.042220343 1.0 70 1.0 1439 12 0.8431 0.6188 61.88 0.08 0.8625 ProteomeLM contextual percentile 0.08; strong pocket/AF2Bind evidence /main_page_ml/ML0488 2026-05-30T13:09:52Z 1591 ML0607 Q49757 ML0607 B1937_F2_39 MLCL536.03c Uncharacterized protein ML0607 279 44.056 Exploratory 0.032 ProteomeLM contextual shift 0.023844512 1.0 66 1.0 871 68 0.9203 0.9313 93.13 0.0 0.8625 ProteomeLM contextual percentile 0.03; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML0607 2026-05-30T13:09:52Z 1592 ML0028 Q50191 ML0028 UPF0301 protein ML0028 202 44.055 Exploratory 0.015 ProteomeLM contextual shift 0.016688686 1.0 32 1.0 625 4 0.7202 0.8303 83.03 0.08 0.8625 ProteomeLM contextual percentile 0.01; strong pocket/AF2Bind evidence; high-confidence Boltz2 model /main_page_ml/ML0028 2026-05-30T13:09:52Z 1593 ML1002 Q7AQB6 ML1002 Possible conserved membrane protein 687 43.869 Exploratory 0.1134 ProteomeLM contextual shift 0.0511394 1.0 135 1.0 2121 0 0.455 0.6275 62.75 0.0 0.8625 ProteomeLM contextual percentile 0.11; strong pocket/AF2Bind evidence /main_page_ml/ML1002 2026-05-30T13:09:52Z 1594 ML0487 P38387 secD ML0487 B1177_C1_164 MLCB1259.05 Protein translocase subunit SecD 571 42.751 Exploratory 0.0157 ProteomeLM contextual shift 0.016945861 1.0 104 1.0 1851 0 0.4502 0.6978 69.78 0.08 0.8625 ProteomeLM contextual percentile 0.02; strong pocket/AF2Bind evidence /main_page_ml/ML0487 2026-05-30T13:09:52Z 1595 ML2137 Q7APY6 ML2137 DUF3071 domain-containing protein 251 42.498 Exploratory 0.0627 ProteomeLM contextual shift 0.03820838 1.0 20 1.0 779 12 0.669 0.668 66.8 0.0 0.8625 ProteomeLM contextual percentile 0.06; strong pocket/AF2Bind evidence /main_page_ml/ML2137 2026-05-30T13:09:52Z 1596 ML2706 Q50201 parB ML2706 Probable chromosome-partitioning protein ParB 333 41.876 Exploratory 0.0144 ProteomeLM contextual shift 0.01575322 1.0 70 1.0 1023 36 0.9728 0.6146 61.46 0.08 0.8625 ProteomeLM contextual percentile 0.01; strong pocket/AF2Bind evidence /main_page_ml/ML2706 2026-05-30T13:09:52Z 1597 ML2429 Q7APU8 ML2429 Possible DNA-binding protein 86 40.998 Exploratory 0.0094 ProteomeLM contextual shift 0.010889064 1.0 12 1.0 297 78 0.8526 0.6494 64.94 0.08 0.7575 ProteomeLM contextual percentile 0.01; strong pocket/AF2Bind evidence /main_page_ml/ML2429 2026-05-30T13:09:52Z