Entry: O69531 Genes: folE ML0223 MLCB2548.08c Length: 205 aa

GTP cyclohydrolase 1

GCH1_MYCLE • Mycobacterium leprae (strain TN)
Navigate Overview Model Scores RCSB 1D Mol* Pockets B-Cell Epitopes Function and interactions Ontology and localisation Sequence features and PTMs Evidence and cross-references

Summary

Download FASTA UniProt: O69531 ML Locus: ML0223
Entry O69531
Reviewed reviewed
Entry Name GCH1_MYCLE
Gene Names folE ML0223 MLCB2548.08c
ML locus tag ML0223
Organism Mycobacterium leprae (strain TN)
Length 205 aa
Mass 22531 Da
Annotation 3.0
Annotation Summary

Evidence and cross-references

PubMed ID 11234002
DOI ID 10.1038/35059006
STRING 272631.gene:17574040;
KEGG mle:ML0223;
eggNOG COG0302;
OrthoDB 9801207at2;
InterPro IPR043133;IPR043134;IPR001474;IPR018234;IPR020602;

Oligomer Models

Best Boltz2 oligomer and local AlphaFold‑3 homooligomer structure models matched to ML0223, with the same model switching, Mol*, Nightingale, pLDDT, PAE, and download functionality as monomers.
Count: 1
Assembly Method Template / Source Overall Rank Download
Homo 10-mer Boltz2 9P8Z 0.613112 Download Model

Ligands

Curated ligands imported from the selected oligomer template/YAML rows. The displayed ligand code is the original template CCD code; predicted-model placeholders such as LIG1/LIG2 are not shown. Click a ligand code to focus the ligand in Mol*.
Ligands: 0
Ligand Code Ligand Name PubChem ID
No curated ligand rows were found for this oligomer in the database.

Monomer Models

Monomer structure models for ML0223, retaining all existing model selection, Mol*, Nightingale, pLDDT, PAE, and download functionality.
Count: 4
Assembly Method Model Overall Rank Download
Monomer Boltz2 0 0.889976 Download Model
Monomer AlphaFold‑3 0 0.925979 Download Model
Monomer Boltz 0 0.895449 Download Model
Monomer CHAI 1 0.179611 Download Model

Sequence & Feature Viewer

Residue-level feature tracks for the loaded model — pLDDT confidence colouring, mapped annotations, and interactive PAE selection ranges. Drag a region on the heatmap to highlight it here and in Mol*.
RCSB 1D
Sequence viewer will initialise once a structure model is loaded.
Mol* — ML0223

Mol* Structure Viewer

Local mmCIF model display for ML0223 with Mol* controls hidden.
Default: Homo 10-mer • Boltz2
Preparing Homo 10-mer • Boltz2 model 0 for ML0223…
Residue focus: none
Heterooligomer ML IDs / chain selection

PAE Map Panel

Predicted aligned error heatmap for the currently loaded model, when pairwise confidence data are available in the local mmCIF.
PAE • Waiting for Model
PAE Heatmap
Loading pairwise confidence data for the selected model…
Scored residue
Aligned residue
Hover over the heatmap to inspect residue-pair PAE values.
Click a cell or drag across the heatmap to select residue blocks and mirror them in the sequence viewer.

B-cell Epitope Propensity

Per-residue conformational B-cell epitope predictions from DiscoTope-3.0.
Epitope · Loading
Low
Epitope
Residue number Residue type DiscoTope-3.0 score Focus
Loading epitope predictions…
Click a residue to focus it in Mol*.
Annotation Summary

Function and interactions

EC number 3.5.4.16
Pathway PATHWAY: Cofactor biosynthesis; 7,8-dihydroneopterin triphosphate biosynthesis; 7,8-dihydroneopterin triphosphate from GTP: step 1/1.
Catalytic activity CATALYTIC ACTIVITY: Reaction=GTP + H2O = 7,8-dihydroneopterin 3'-triphosphate + formate + H(+); Xref=Rhea:RHEA:17473, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15740, ChEBI:CHEBI:37565, ChEBI:CHEBI:58462; EC=3.5.4.16;
Binding site BINDING 93; /ligand="Zn(2+)"; /ligand_id="ChEBI:CHEBI:29105"; /evidence="ECO:0000250"; BINDING 96; /ligand="Zn(2+)"; /ligand_id="ChEBI:CHEBI:29105"; /evidence="ECO:0000250"; BINDING 166; /ligand="Zn(2+)"; /ligand_id="ChEBI:CHEBI:29105"; /evidence="ECO:0000250"
Subunit structure SUBUNIT: Toroid-shaped homodecamer, composed of two pentamers of five dimers. {ECO:0000250}.
Annotation Summary

Ontology and localisation

Gene Ontology (biological process) one-carbon metabolic process [GO:0006730]; tetrahydrobiopterin biosynthetic process [GO:0006729]; tetrahydrofolate biosynthetic process [GO:0046654]
Gene Ontology (cellular component) cytoplasm [GO:0005737]
Gene Ontology (GO) cytoplasm [GO:0005737]; GTP binding [GO:0005525]; GTP cyclohydrolase I activity [GO:0003934]; zinc ion binding [GO:0008270]; one-carbon metabolic process [GO:0006730]; tetrahydrobiopterin biosynthetic process [GO:0006729]; tetrahydrofolate biosynthetic process [GO:0046654]
Gene Ontology (molecular function) GTP binding [GO:0005525]; GTP cyclohydrolase I activity [GO:0003934]; zinc ion binding [GO:0008270]
Gene Ontology IDs GO:0003934; GO:0005525; GO:0005737; GO:0006729; GO:0006730; GO:0008270; GO:0046654
Protein families GTP cyclohydrolase I family
Sequence similarities SIMILARITY: Belongs to the GTP cyclohydrolase I family. {ECO:0000305}.
Annotation Summary

Sequence features and PTMs

Chain CHAIN 1..205; /note="GTP cyclohydrolase 1"; /id="PRO_0000119422"