Entry: Q9CCG6 Genes: furB ML0824 Length: 131 aa

Zinc uptake regulation protein

Q9CCG6_MYCLE • Mycobacterium leprae (strain TN)
Navigate Overview Model Scores RCSB 1D Mol* Pockets B-Cell Epitopes Function and interactions Ontology and localisation Evidence and cross-references

Summary

Download FASTA UniProt: Q9CCG6 ML Locus: ML0824
Entry Q9CCG6
Reviewed unreviewed
Entry Name Q9CCG6_MYCLE
Gene Names furB ML0824
ML locus tag ML0824
Organism Mycobacterium leprae (strain TN)
Length 131 aa
Mass 14593 Da
Annotation 2.0
Annotation Summary

Evidence and cross-references

PubMed ID 11234002
DOI ID 10.1038/35059006
STRING 272631.gene:17574649;
KEGG mle:ML0824;
eggNOG COG0735;
OrthoDB 8659436at2;
InterPro IPR002481;IPR043135;IPR036388;IPR036390;

Oligomer Models

Best Boltz2 oligomer and local AlphaFold‑3 homooligomer structure models matched to ML0824, with the same model switching, Mol*, Nightingale, pLDDT, PAE, and download functionality as monomers.
Count: 2
Assembly Method Template / Source Overall Rank Download
Homo 2-mer Boltz2 2O03 0.930369 Download Model
homo 2-mer AlphaFold‑3 — — Download Model

Ligands

Curated ligands imported from the selected oligomer template/YAML rows. The displayed ligand code is the original template CCD code; predicted-model placeholders such as LIG1/LIG2 are not shown. Click a ligand code to focus the ligand in Mol*.
Ligands: 0
Ligand Code Ligand Name PubChem ID
No curated ligand rows were found for this oligomer in the database.

Monomer Models

Monomer structure models for ML0824, retaining all existing model selection, Mol*, Nightingale, pLDDT, PAE, and download functionality.
Count: 4
Assembly Method Model Overall Rank Download
Monomer Boltz2 0 0.794415 Download Model
Monomer AlphaFold‑3 3 0.749531 Download Model
Monomer Boltz 0 0.776955 Download Model
Monomer CHAI 4 0.133926 Download Model

Sequence & Feature Viewer

Residue-level feature tracks for the loaded model — pLDDT confidence colouring, mapped annotations, and interactive PAE selection ranges. Drag a region on the heatmap to highlight it here and in Mol*.
RCSB 1D
Sequence viewer will initialise once a structure model is loaded.
Mol* — ML0824

Mol* Structure Viewer

Local mmCIF model display for ML0824 with Mol* controls hidden.
Default: Homo 2-mer • Boltz2
Preparing Homo 2-mer • Boltz2 model 0 for ML0824…
Residue focus: none
Heterooligomer ML IDs / chain selection

PAE Map Panel

Predicted aligned error heatmap for the currently loaded model, when pairwise confidence data are available in the local mmCIF.
PAE • Waiting for Model
PAE Heatmap
Loading pairwise confidence data for the selected model…
Scored residue
Aligned residue
Hover over the heatmap to inspect residue-pair PAE values.
Click a cell or drag across the heatmap to select residue blocks and mirror them in the sequence viewer.

B-cell Epitope Propensity

Per-residue conformational B-cell epitope predictions from DiscoTope-3.0.
Epitope · Loading
Low
Epitope
Residue number Residue type DiscoTope-3.0 score Focus
Loading epitope predictions…
Click a residue to focus it in Mol*.
Annotation Summary

Function and interactions

Binding site BINDING 80; /ligand="Fe cation"; /ligand_id="ChEBI:CHEBI:24875"; /evidence="ECO:0000256|PIRSR:PIRSR602481-2"; BINDING 86; /ligand="Zn(2+)"; /ligand_id="ChEBI:CHEBI:29105"; /evidence="ECO:0000256|PIRSR:PIRSR602481-1"; BINDING 89; /ligand="Zn(2+)"; /ligand_id="ChEBI:CHEBI:29105"; /evidence="ECO:0000256|PIRSR:PIRSR602481-1"; BINDING 101; /ligand="Fe cation"; /ligand_id="ChEBI:CHEBI:24875"; /evidence="ECO:0000256|PIRSR:PIRSR602481-2"; BINDING 118; /ligand="Fe cation"; /ligand_id="ChEBI:CHEBI:24875"; /evidence="ECO:0000256|PIRSR:PIRSR602481-2"; BINDING 126; /ligand="Zn(2+)"; /ligand_id="ChEBI:CHEBI:29105"; /evidence="ECO:0000256|PIRSR:PIRSR602481-1"; BINDING 129; /ligand="Zn(2+)"; /ligand_id="ChEBI:CHEBI:29105"; /evidence="ECO:0000256|PIRSR:PIRSR602481-1"
Cofactor COFACTOR: Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence={ECO:0000256|PIRSR:PIRSR602481-2}; Name=Fe(2+); Xref=ChEBI:CHEBI:29033; Evidence={ECO:0000256|PIRSR:PIRSR602481-2}; Note=Binds 1 Mn(2+) or Fe(2+) ion per subunit. {ECO:0000256|PIRSR:PIRSR602481-2}; COFACTOR: Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence={ECO:0000256|PIRSR:PIRSR602481-1}; Note=Binds 1 zinc ion per subunit. {ECO:0000256|PIRSR:PIRSR602481-1};
Subunit structure SUBUNIT: Homodimer. {ECO:0000256|ARBA:ARBA00011738}.
Annotation Summary

Ontology and localisation

Gene Ontology (biological process) negative regulation of DNA-templated transcription [GO:0045892]; regulation of secondary metabolite biosynthetic process [GO:1900376]
Gene Ontology (cellular component) cytosol [GO:0005829]
Gene Ontology (GO) cytosol [GO:0005829]; DNA-binding transcription factor activity [GO:0003700]; transcription cis-regulatory region binding [GO:0000976]; zinc ion binding [GO:0008270]; negative regulation of DNA-templated transcription [GO:0045892]; regulation of secondary metabolite biosynthetic process [GO:1900376]
Gene Ontology (molecular function) DNA-binding transcription factor activity [GO:0003700]; transcription cis-regulatory region binding [GO:0000976]; zinc ion binding [GO:0008270]
Gene Ontology IDs GO:0000976; GO:0003700; GO:0005829; GO:0008270; GO:0045892; GO:1900376
Subcellular location [CC] SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Protein families Fur family
Sequence similarities SIMILARITY: Belongs to the Fur family. {ECO:0000256|ARBA:ARBA00007957}.