Entry: Q9X798 Genes: rpoA ML1957 MLCB1222.27c Length: 347 aa

DNA-directed RNA polymerase subunit alpha (RNAP subunit alpha)

RPOA_MYCLE • Mycobacterium leprae (strain TN)
Navigate Overview Model Scores RCSB 1D Mol* Pockets B-Cell Epitopes Function and interactions Ontology and localisation Sequence features and PTMs Evidence and cross-references

Summary

Download FASTA UniProt: Q9X798 ML Locus: ML1957
Entry Q9X798
Reviewed reviewed
Entry Name RPOA_MYCLE
Gene Names rpoA ML1957 MLCB1222.27c
ML locus tag ML1957
Organism Mycobacterium leprae (strain TN)
Length 347 aa
Mass 37702 Da
Annotation 3.0
Annotation Summary

Evidence and cross-references

PubMed ID 11234002
DOI ID 10.1038/35059006
STRING 272631.gene:17575809;
KEGG mle:ML1957;
eggNOG COG0202;
OrthoDB 9805706at2;
InterPro IPR011262;IPR011263;IPR011773;IPR036603;IPR011260;IPR036643;

Oligomer Models

Best Boltz2 oligomer and local AlphaFold‑3 homooligomer structure models matched to ML1957, with the same model switching, Mol*, Nightingale, pLDDT, PAE, and download functionality as monomers.
Count: 1
Assembly Method Template / Source Overall Rank Download
heterooligomer Boltz2 — — Download Model

Ligands

Curated ligands imported from the selected oligomer template/YAML rows. The displayed ligand code is the original template CCD code; predicted-model placeholders such as LIG1/LIG2 are not shown. Click a ligand code to focus the ligand in Mol*.
Ligands: 0
Ligand Code Ligand Name PubChem ID
No curated ligand rows were found for this oligomer in the database.

Monomer Models

Monomer structure models for ML1957, retaining all existing model selection, Mol*, Nightingale, pLDDT, PAE, and download functionality.
Count: 4
Assembly Method Model Overall Rank Download
Monomer Boltz2 0 0.848559 Download Model
Monomer AlphaFold‑3 3 0.722439 Download Model
Monomer Boltz 0 0.855664 Download Model
Monomer CHAI 2 0.143335 Download Model

Sequence & Feature Viewer

Residue-level feature tracks for the loaded model — pLDDT confidence colouring, mapped annotations, and interactive PAE selection ranges. Drag a region on the heatmap to highlight it here and in Mol*.
RCSB 1D
Sequence viewer will initialise once a structure model is loaded.
Mol* — ML1957

Mol* Structure Viewer

Local mmCIF model display for ML1957 with Mol* controls hidden.
Default: heterooligomer • Boltz2
Preparing heterooligomer • Boltz2 model 0 for ML1957…
Residue focus: none
Heterooligomer ML IDs / chain selection

PAE Map Panel

Predicted aligned error heatmap for the currently loaded model, when pairwise confidence data are available in the local mmCIF.
PAE • Waiting for Model
PAE Heatmap
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Scored residue
Aligned residue
Hover over the heatmap to inspect residue-pair PAE values.
Click a cell or drag across the heatmap to select residue blocks and mirror them in the sequence viewer.

B-cell Epitope Propensity

Per-residue conformational B-cell epitope predictions from DiscoTope-3.0.
Epitope · Loading
Low
Epitope
Residue number Residue type DiscoTope-3.0 score Focus
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Annotation Summary

Function and interactions

EC number 2.7.7.6
Catalytic activity CATALYTIC ACTIVITY: Reaction=RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate; Xref=Rhea:RHEA:21248, Rhea:RHEA-COMP:14527, Rhea:RHEA-COMP:17342, ChEBI:CHEBI:33019, ChEBI:CHEBI:61557, ChEBI:CHEBI:140395; EC=2.7.7.6; Evidence={ECO:0000255|HAMAP-Rule:MF_00059};
Subunit structure SUBUNIT: Homodimer. The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription. {ECO:0000255|HAMAP-Rule:MF_00059}.
Annotation Summary

Ontology and localisation

Gene Ontology (biological process) DNA-templated transcription [GO:0006351]
Gene Ontology (cellular component) cytoplasm [GO:0005737]; DNA-directed RNA polymerase complex [GO:0000428]
Gene Ontology (GO) cytoplasm [GO:0005737]; DNA-directed RNA polymerase complex [GO:0000428]; DNA binding [GO:0003677]; DNA-directed RNA polymerase activity [GO:0003899]; protein dimerization activity [GO:0046983]; DNA-templated transcription [GO:0006351]
Gene Ontology (molecular function) DNA binding [GO:0003677]; DNA-directed RNA polymerase activity [GO:0003899]; protein dimerization activity [GO:0046983]
Gene Ontology IDs GO:0000428; GO:0003677; GO:0003899; GO:0005737; GO:0006351; GO:0046983
Protein families RNA polymerase alpha chain family
Sequence similarities SIMILARITY: Belongs to the RNA polymerase alpha chain family. {ECO:0000255|HAMAP-Rule:MF_00059}.
Annotation Summary

Sequence features and PTMs

Chain CHAIN 1..347; /note="DNA-directed RNA polymerase subunit alpha"; /id="PRO_0000175337"
Region REGION 1..226; /note="Alpha N-terminal domain (alpha-NTD)"; /evidence="ECO:0000255|HAMAP-Rule:MF_00059"; REGION 243..347; /note="Alpha C-terminal domain (alpha-CTD)"; /evidence="ECO:0000255|HAMAP-Rule:MF_00059"; REGION 326..347; /note="Disordered"; /evidence="ECO:0000256|SAM:MobiDB-lite"
Domain [CC] DOMAIN: The N-terminal domain is essential for RNAP assembly and basal transcription, whereas the C-terminal domain is involved in interaction with transcriptional regulators and with upstream promoter elements. {ECO:0000255|HAMAP-Rule:MF_00059}.